39results about How to "Non-invasive testing" patented technology

The present invention discloses a kind of respiration detecting method and apparatus for diagnosing lung cancer in early stage. The method includes solid phase micro extraction to pre-enrich the exhaled gas of the patient, inserting the solid phase micro extraction with adsorbed organic gas component into hot gas desorbing unit to desorb, separating the desorbed organic gas component with vapor capillary chromatographic column, adsorbing the organic gas component with the organic gas sensing film in the detecting head of one pair of HF delay line ASW sensors to detect the organic gas content, and performing image processing and nerve network mode distinction on 11 kinds of detected lung cancer labeling organic components to diagnose lung cancer patient. The technology of the present invention may be also used for detecting volatile organic matters in other various fields.

The invention belongs to the technical field of human body physiological parameter measurement, and relates to a reflective pulse blood oxygen detecting method based on diffusion theory, which includes the steps: (1) establishing the relationship between organizer absorption coefficient and SaO2 (oxygen saturation); (2) establishing the relationship between reflection light intensity and organizer absorption coefficient; (3) establishing the relationship between an R value and the reflection light intensity; (4) acquiring pulse wave signals of a red light wavelength and a near-infrared light wavelength; (5) detecting features of pulse wave signals of the infrared light wavelength to extract peak values which are the maximum value and the minimal value of the reflection light intensity; (6) calculating blood oxygen saturation coefficient R; and (7) plugging the R value into a calibration curve to obtain needed blood oxygen saturation coefficient in real time. The reflective pulse blood oxygen detecting method based on the diffusion theory can be used for realizing non-invasive real-time measurement, and is higher in precision and wider in application range.

An optical test device for the tissue of living body is composed of light emitter unit, optical fiber probe, optical spectrum analyzing and data processing unit, emitting optical fibers, receiving optical fibers, and optical switch. Its detecting method is also disclosed.

The invention discloses a flexible temperature-sensitive sensor. The flexible temperature-sensitive sensor comprises a flexible substrate, a temperature-sensitive material layer, an electrode layer and a flexible protection layer, wherein the temperature-sensitive material layer is formed on the surface of the flexible substrate and provided with a three-dimensional porous nano-structure; the electrode layer comprises at least two electrodes, and the electrodes are led out from the temperature-sensitive material layer or the surface of the temperature-sensitive material layer; the flexible protection layer is formed on the surface of the temperature-sensitive material layer or the surface of the temperature-sensitive material layer and the portion of the electrode layer, on the surface of the temperature-sensitive material layer. The invention further discloses a body temperature monitoring system based on the flexible temperature-sensitive sensor. The sensor disclosed by the invention is light, thin and soft, capable of being machined into various shapes, and capable of being attached and worn on the surface of the skin as clothes; the sensor and the monitoring system have the advantages of being high in sensitivity, simple to operate, non-invasive, accurate in measurement result, and capable of continuously recording body temperature changes.

The present invention discloses a noninvasive blood glucose detection instrument basing on the energy conservation principle, which includes a blood glucose detection sensor, a signal processing circuit, a simulation filter circuit, an amplifying circuit, an A / D converter, a communication circuit, a display, a single chip microcomputer, a personal computer and a blood oxygen detection module. The blood glucose detection sensor, the signal processing circuit, the simulation filter circuit, the amplifying circuit and the A / D converter are connected successively in series. The blood glucose detection instrument detects physiological quantity signals of a human body. The signals are pretreated by the signal processing circuit, the simulation filter circuit and the amplifying circuit and are converted into digital signals by the A / D converter to be transmitted to the single chip microcomputer. Then, the digital signals are transmitted to the personal computer through a communication circuit. The personal computer processes the detected data, finishes the calculation of the blood glucose concentration and displays the calculation results. Through the parameters of the detections of the convection, the radiation and the heat evaporation dissipating capacity of finger surfaces, the blood flow and the blood oxygen saturation of local tissues, etc., the present invention realizes the blood glucose fast detection, which has the advantages of painless performance, disinfection and simple and rapid performances.

The invention discloses a device and a method for detecting the absolute amount of the blood oxygen and the blood volume of local brain tissue. The device comprises an optical probe and a controller; the optical probe is used for emitting the near-infrared light to the surface of the local brain tissue to be detected and detecting the light intensity which is reflected from the surface of the local brain tissue to be detected; the controller is used for controlling the emission of the optical probe and obtaining optical signals. According to the device and the method for detecting the absolute amount of the blood oxygen and the blood volume of the local brain tissue, a multi-wavelength light source is selected, continuous waves are utilized, and accordingly the price is low, the signals are stable, the method is easy to implement, and the rapid popularization can be achieved; a common photosensitive detector is adopted and accordingly the high measurement sensitivity is ensured and the portability of the instrument is greatly improved; an absolute value of the blood oxygen and blood volume amount of the local brain tissue can be detected noninvasively, timely, rapidly and accurately and accordingly the differences between the lesion area and the normal area or the differences between patients and normal persons can be accurately reflected.

The invention provides a heart failure detection method based on an electrocardio-interval sequence normalized histogram and a device thereof. The detection method comprises the following steps: (1) electrocardiosignals of a testee are collected; (2) the analog-digital conversion is carried out on the electrocardiosignals, and electrocardio-waveform data are stored; (3) R wave peak value points of the electrocardiosignals are extracted to construct an electrocardio-interval sequence RR; (4) the effectiveness of the RR sequence is tested; (5) the RR electrocardio-interval sequence normalized histogram is constructed; (6) two specific indexes of center-edge rate (CER) and cumulative energy (CE) of the normalized histogram are calculated; (7) the heart failure course of the testee is evaluated according to the indexes of CER and CE. The detection device comprises an electrocardiosignal detection module, an analog-digital conversion device and a computer. Based on the two specific indexes of CER and CE of the electrocardio-interval sequence normalized histogram, the heart failure course of the testee is evaluated, the heart failure course of the testee can be detected noninvasively, conveniently and quantitatively, and the discrimination index is high.

The invention relates to the technical field of clinical molecular diagnosis, in particular to a superficial modification based 5hmC (5-hydroxymethylcytosine) polymolecular marker and a CRC (colorectal cancer) early diagnosis model. With the adoption of a 5-hmC high throughput sequencing technology, 5-hmC expression quantities of peripheral blood plasma DNA whole genomes of a CRC patient and a healthy person are checked, 5-hmC differential expression of genetic loci of the whole genomes of the two groups of samples are compared, the genetic locus of the part with the most obvious differentialexpression is screened as the gene marker of the diagnosis model, and then the CRC early diagnosis model is constructed. Verification proves that the diagnosis sensitivity and specificity are both higher, and compared with a stool occult blood detection kit and a spetin9 kit in the market currently, sensitivity and specificity are improved by about 20% and 8% respectively. The diagnosis method hasthe advantages of being noninvasive in detection and convenient, can be applied to the first-line clinic and is used for early screening of CRC.

The invention relates to a kit and a method for predicting a hepatocarcinogenesis risk, relating to the technical field of medical in-vitro diagnosis. Particularly, the invention relates to a kit anda method for predicting a hepatocarcinogenesis risk through the CpG island methylation states of single genes or multiple genes in SCT, NFIX, IGF2, ABCG5, GSTO2, SARDH, E2F6, SHANK2, GATA4, OPLAH, NR2F1 and ZFHX3. According to the combined methylation detection of the multiple genes, the sensitivity is greatly improved; the free nucleic acids of saliva, urine, blood and the like are detected, drawing materials from cancer tissue is not required, the detection is noninvasive, and the operation is simple and convenient.

The invention discloses a noninvasive blood sugar measuring device adopting serial dual-infrared spectrum detection and analysis, belongs to the fields of optical measurement and novel medical detection devices, and especially relates to noninvasive human body blood sugar detection. The device is mainly composed of a broadband infrared light source, a double-optical filter switcher, an infrared photoelectric sensor, a signal acquiring and processing circuit and the like. The device adopts a transmission spectrum measurement way; a light beam emitted by the broadband infrared light source is irradiated on relevant parts of a human body to be tested, such as fingertips and palms, penetrates through human body tissues, reacts with blood, and then enters the double-optical filter switcher; andthe double-optical filter switcher adopts a serial working mode, and allows light beams with two different wavelengths to go through an optical filter and then received by the unit infrared photoelectric sensor. The signal acquiring and processing circuit converts the electrical signal of the infrared photoelectric sensor into a digital signal, and analyzes and calculates the signals of the two different wavelengths to finally obtain human body blood sugar concentration information.

The invention relates to a multifunctional double-infrared-blood-vessel development instrument and a development method thereof. The development instrument comprises a portable housing, wherein a power module, an image acquisition module, a double-infrared-light-source module, an operation processing module and a development module are arranged in the housing, a wireless transmission module is further arranged in the housing, and the power module supplies power for other modules. The output end of the image acquisition module is connected with the input end of the operation processing module, the output end of the operation processing module is connected with the development module and the wireless transmission module respectively, the double-infrared-light-source module consists of LED lamps with 850 nm wavelengths and LED lamps with 940 nm wavelengths, and the image acquisition module comprises a sensor and a band-pass light filter installed in front of the sensor. The multifunctional double-infrared-blood-vessel development instrument improves the accuracy and success rate of medical puncture, facilitates examination of body surface lumps, phlebothrombosis, blood flow information or internal haemorrhage situation and can be used for self detection in hospitals or at home. A wireless transmission function makes a device perform remote diagnosis, and the usage limitation of the device is reduced.

The invention relates to an oval foramen unclosed detection method and system, a terminal and a storage medium. The method comprises the following steps: respectively carrying out left atrium ROI segmentation on each frame of image in atrial apex four-cavity tangent plane view angle dynamic image data, wherein the cardiac apex four-cavity tangent plane view angle dynamic image data comprises TTE image data and cTTE image data in a set number of cardiac cycles; calculating the gray scale of the left atrium ROI of each frame of image in the TTE image data, screening out the minimum gray scale distribution interval of the TTE image data, and screening out the cTTE image of the corresponding interval in the cTTE image data according to the minimum gray scale distribution interval of the TTE image data; carrying out microbubble detection and feature extraction on the screened cTTE images, inputting the microbubble detection and feature extraction into a trained prediction model, and outputting an oval hole closing state detection result through the prediction model. Non-invasive PFO detection is realized, the operation is simple, the accuracy is high, and the detection rate and the detection efficiency are improved.

The invention discloses a noninvasive blood sugar detection device based on a raman scattering spectrum. The noninvasive blood sugar detection device based on a raman scattering spectrum comprises a semiconductor laser, an optical fiber beam splitter, an optical fiber probe, a light filter, a raman spectrometer, a first circuit switch, a second circuit switch, a phase locking amplifier, a heart rate measuring apparatus and a computer. According to the noninvasive blood sugar detection device based on a raman scattering spectrum disclosed by the invention, raman scattering light contains rich molecular vibration information, the characteristics that the raman scattering spectrum having different molecules has different features are utilized, the raman scattering spectrum is used for recognizing molecules; and through the relative value of a glucose characteristic peak at the position of 1125cm-1 in the raman scattering spectrum in pure blood to the hemoglobin characteristic peak value at the position of 1549cm-1, and real-time human body blood sugar concentration data measured by a blood sugar biochemistry instrument, a standard straight line L of the relationship between the relative peak value of the glucose characteristic peak at the position of 1125cm-1 and the human body blood sugar concentration is constructed, and finally noninvasive real-time detection of the human bodyblood sugar is realized. The noninvasive blood sugar detection device disclosed by the invention has the advantages of being high in precision, pollution-free, harmless to human bodies and the like, and has great application prospects in the field of biological noninvasive detection.

The present invention discloses a labor analgesia method and an analgesia device. The analgesia method is as follows: firstly, pregnant women are injected with analgesic, then body temperatures of the pregnant women are scanned, skin temperature changes of the pregnant women after analgesia are detected, an anesthesia plane is confirmed, and then according to differences between an actual anesthesia plane and an ideal anesthesia plane, analgesic dose is added until the analgesia is completed. The analgesia device comprises a skin temperature detecting probe, a PLC controller and an analgesia pump, the skin temperature detecting probe is in a communication connection with the PLC controller, and the analgesia pump is electrically connected with the PLC controller. The used device and method can effectively solve technical problems of labor difficulties of the pregnant women.

The invention discloses a kit used for evaluating ovarian cancer primary chemotherapeutic sensitivity, and an application thereof. The kit comprises a blocking reagent, an antigen-antibody reaction system, an avidin-oxide enzyme reaction system and a counterstaining drug. The invention is provided based on the relevance between the expression level of ERCC2 in serous ovarian cancer cells / tissues and sensitivity of cells, tissues or a tumor patient as a host to a primary chemotherapeutic drug. Through ERCC2 detection, purposes such as chemotherapeutic sensitivity / drug resistance evaluation, tumor patient discrimination, and primary chemotherapeutic drug tolerability evaluation can be achieved. The method provided by the invention is simple and accurate. The requirement on a sample is not high. Therefore, the kit and the method can be used in large-scale screening or trace researches. When the kit and the method is used in clinical diagnosis and medication guidance, ex vivo cancer tissues of a patient can be acquired for detection after operation, and the detection is characterized in no wound, no pain, and noninvasiveness. The detection can easily be accepted by patients. With the kit and the application, patient lives can be prolonged, chemotherapy pains of the patients can be alleviated, and life qualities of the patients after operations can be improved.

The invention relates to a lung cancer early screening marker, a detection method, a detection device and a computer readable medium, WGS low-depth sequencing is carried out on plasma sample cfDNA, a sequence 8mer (Motif end8mer) at a breakpoint at the tail ends of differential DNA fragments between lung cancer and healthy people is analyzed according to a high-throughput sequencing result, a model is constructed, and the purpose of noninvasive accurate diagnosis of lung cancer is achieved.

The invention relates to the technical field of blood pressure detection and relates to a blood pressure automatic measuring device and method based on digital control. The measuring device comprises a volume pulse wave acquisition module, a blood pressure acquisition module and a processing module. The volume pulse wave acquisition module is used for acquiring volume pulse waves of a measured object and processing the acquired volume pulse waves to acquire pulse oximeter signals. The blood pressure acquisition module is used for acquiring blood pressure information of the measured object regularly and processing the acquired blood pressure information to acquire blood pressure digital signals. The processing module comprises a first processing unit and a second processing unit. The first processing unit is used for receiving and processing the blood pressure digital signals and transmitting the blood pressure digital signals to the second processing unit, and the second processing unit is used for extracting multiple feature points of the pulse oximeter signals and jointly carrying out fitting operation on the feature points and the blood pressure digital signals to establish a blood pressure parameter measuring model. The measuring method is achieved through the measuring device. Blood pressure is automatically and continuously measured well.

The invention discloses a circuit system for measuring pulse and blood oxygen saturation degree, and relates to the field of design of analogue integrated circuits. The circuit system comprises a front-mounted differential amplification circuit, a baselinedrift suppressing circuit, a low-pass filtering circuit, a high-pass filtering circuit, a second-stage alternating current amplifying circuit and a power supply management module. According to the circuit system disclosed by the invention, a pulse blood oxygen signal is acquired by adopting a reflective blood oxygen sensor probe, and an acquired physiological signal is fed into a researched circuit system for processing. An operational amplifier is designed by using a UMC-18-CMOS 1P6M process, then the amplifying circuit and the filtering circuits are set up so as to realize amplifying and filtering of the acquired pulse blood oxygen signal, and finally a direct current value and an alternating current value of pulse waves are obtained. Meanwhile, signal loss and the occupied space are reduced, and the reliability and the stability are improved.

The invention provides a portable device for diagnosis of lung cancer, which comprises a balloon, a gas pump, a buffer gas chamber, a reaction gas chamber, an image collection and processing system and a control system; the balloon collects exhaled gas of a patient with suspected lung cancer to carry out the reaction with a pre-designed porphyrin sensor array (the sensor array for detecting lung cancer markers, if the lung cancer markers exist, the color of the sensor array is changed before and after the reaction) in the reaction gas chamber, the collection of images before and after the reaction is realized by controlling the image collection and processing system through the control system, the images are compared, the collected images are carried out with the pretreatment to obtain the differential images before and after the reaction, the differential images are further compared with data in an expert lesion database to obtain the detection result, and the detection result is finally displayed through a liquid crystal screen or a micro-printer, thereby judging whether the patient suffers from the lung cancer or not.

The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier.

The invention discloses a flexible temperature-sensitive sensor. The flexible temperature-sensitive sensor comprises a flexible substrate, a temperature-sensitive material layer, an electrode layer and a flexible protection layer, wherein the temperature-sensitive material layer is formed on the surface of the flexible substrate and provided with a three-dimensional porous nano-structure; the electrode layer comprises at least two electrodes, and the electrodes are led out from the temperature-sensitive material layer or the surface of the temperature-sensitive material layer; the flexible protection layer is formed on the surface of the temperature-sensitive material layer or the surface of the temperature-sensitive material layer and the portion of the electrode layer, on the surface of the temperature-sensitive material layer. The invention further discloses a body temperature monitoring system based on the flexible temperature-sensitive sensor. The sensor disclosed by the invention is light, thin and soft, capable of being machined into various shapes, and capable of being attached and worn on the surface of the skin as clothes; the sensor and the monitoring system have the advantages of being high in sensitivity, simple to operate, non-invasive, accurate in measurement result, and capable of continuously recording body temperature changes.

The invention discloses a peripheral blood circular RNA marker for noninvasive diagnosis of active pulmonary tuberculosis. A primer is designed according to the peripheral blood circular RNA marker; the designed primer can be used for preparing a noninvasive diagnosis kit used for the active pulmonary tuberculosis. The peripheral blood circular RNA marker can be used for effectivelydistinguishing patients with pulmonary tuberculosis from healthy people, and has the advantages of convenient and noninvasive detection, high accuracy and good stability, thus being suitable for being popularized and used.

The invention provides a radioactive metal element labeled micromolecular cyclopeptide. The radioactive metal element labeled micromolecular cyclopeptide is characterized by being a compound as shown in a formula (I), namely c(X1HWGFTLX2) -Y-Z(I), wherein c(X1HWGFTLX2) is a cyclopeptide formed by binding 8-10 amino acids; each of X1 and X2 is at least one amino acid group; Y is a chelating ligand; Z is 68Ga and is chelated with Y; the cyclopeptide contains a free amino acid which is matched with Y. The invention also provides a composition containing the micromolecular cyclopeptide and the application of the micromolecular cyclopeptide as a tumor developer. The micromolecular cyclopeptide c(X1HWGFTLX2) -Y-Z(I) is small in molecular weight, quick in blood clarification, high in tissue intake, good in penetrability, high in sensitivity, simple in radiochemical synthesis process and good clinical application prospect; as a result, good basis can be provided for the subsequent research or the clinical diagnosis of medical workers.

The invention relates to a living tissue detection device and a working method thereof. The detection device of the present invention includes a light source transmitting unit, an optical fiber probe, a spectrum analysis and data processing unit, a transmitting optical fiber, a receiving optical fiber and an optical switch; All or part of the distances between the root optical fiber and each optical fiber in the receiving optical fiber are different, and the number of these different distances is greater than or equal to two. The working method of the detection device of the present invention is: use the ratio sequence obtained by comparing the light intensity information of each wavelength in the diffuse reflection light of the living tissue obtained through detection with the light intensity reference to obtain the diffuse reflection spectrum signal, and control the optical switch. The state detects the states of different depths of the living tissue to obtain the detection results. The invention not only can perform tomographic optical detection, but also has high detection precision.

The non -invasive blood glucose detection device based on the Raman scattering spectrometer includes semiconductor lasers, fiber fiber signs, optical fiber probes, filters, Raman spectrometers, first circuit switches, second circuit switchesYimen computer; the present invention uses the rich molecular vibration information contained in Raman's scattered light, and uses different molecular scattering spectra to identify the molecules with the Raman scattered spectrum, through the pure blood, through the pure blood1125cm in Raman scattering spectrum ‑1 Glucose characteristic peak for 1549cm ‑1 The relative values of the peak value of hemoglobin at the point and the real -time human blood glucose concentration data measured by the blood glucose biochemical meter measurement, establish 1125cm ‑1 The relative peak of glucose characteristics peaks and human blood glucose concentration standards straight line L, eventually realized non -invasive and real -time testing of human blood sugar; the present invention has the advantages of high accuracy, pollution -free, harmless to the human body, and in the field of biological non -invasive testing.Wide application prospects.

The invention discloses a near-infrared two-region activated probe and application thereof. The near-infrared two-region activated probe comprises a detection system and an amplification system, wherein the detection system is composed of a first chain probe, a second chain probe and a third chain probe, and the amplification system is composed of a to-be-detected target sequence, the second chain probe, the third chain probe and a fourth chain probe; the second-chain probe and the third-chain probe are completely complementary, and the first-chain probe and the fourth-chain probe are partially complementary with the third-chain probe in sequence; and a part of sequences in the third chain probe are completely complementary to the to-be-detected target sequence, and a part of sequences in the first chain and the fourth chain are partially identical to the to-be-detected target sequence. Toe-hold strand displacement reaction and near-infrared two-region fluorescence are combined, and the constructed near-infrared two-region activated probe can perform high-sensitivity, high-specificity and rapid detection on breast cancer sentinel lymph node metastasis on the living body level and has important significance on early diagnosis of breast cancer metastasis.

The invention discloses a device and a method for detecting the absolute amount of the blood oxygen and the blood volume of local brain tissue. The device comprises an optical probe and a controller; the optical probe is used for emitting the near-infrared light to the surface of the local brain tissue to be detected and detecting the light intensity which is reflected from the surface of the local brain tissue to be detected; the controller is used for controlling the emission of the optical probe and obtaining optical signals. According to the device and the method for detecting the absolute amount of the blood oxygen and the blood volume of the local brain tissue, a multi-wavelength light source is selected, continuous waves are utilized, and accordingly the price is low, the signals are stable, the method is easy to implement, and the rapid popularization can be achieved; a common photosensitive detector is adopted and accordingly the high measurement sensitivity is ensured and the portability of the instrument is greatly improved; an absolute value of the blood oxygen and blood volume amount of the local brain tissue can be detected noninvasively, timely, rapidly and accurately and accordingly the differences between the lesion area and the normal area or the differences between patients and normal persons can be accurately reflected.

The invention provides a radioactive halogen marked micromolecule cyclic peptide, which is characterized in that the micromolecule cyclic peptide is a chemical as shown in the formula (I): c(X1HWGFTLX2)-Y-Z (I), in the formula, c(X1HWGFTLX2) is a cyclic peptide formed by 8-10 combined amino acids, X1 and X2 are both at least one amino acid residue, Y is chelated ligand, Z is a metal compound containing radioactive halogen which is chelated with Y. The invention further provides a compound containing the micromolecule cyclic peptide, and application of the micromolecule cyclic peptide as a tumor developing agent. The radioactive halogen marked micromolecule cyclic peptide provided by the invention not only can be targeted to tumor cells, but also is high in permeability, can perform positioning expression on deep tissue, and is relatively good in clinical application prospect, and relatively good basis for later research or diagnosis on tumor can be provided for medical operators.

The invention discloses a non-invasive blood lipid detection device and detection method based on near-infrared spectroscopy, wherein the detection device includes a broadband light source laser, an optical fiber beam splitter, a first focusing lens, a second focusing lens, a first optical fiber probe, and a second optical fiber probe, the third focusing lens, the fourth focusing lens, the first near-infrared spectrometer, the second near-infrared spectrometer, a lock-in amplifier, a heart rate measuring instrument and a computer; The relative value of the characteristic peak of blood lipid to the characteristic peak of hemoglobin at 2298nm and the known blood lipid content of the human body, a large amount of data fitting to obtain the relationship curve between the relative intensity of the characteristic peak of blood lipid in the near-infrared transmission spectrum and the content of blood lipid, and then detect the real-time blood lipid of the human body content. The invention has many advantages such as real-time detection, rapidity, safety and environmental protection, and has broad application prospects in the fields of biological non-invasive detection and disease prevention and treatment.