Lung cancer early screening marker, model construction method, detection device and computer readable medium

A technology for constructing methods and markers, applied in the field of molecular biomedicine, can solve the problems of restricting screening methods, insufficient diagnostic sensitivity and failing to meet clinical requirements, unable to meet the needs of screening, etc., achieving high detection specificity and sensitivity, The effect of low flux

Active Publication Date: 2021-09-07
GENESEEQ TECH INC +1
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the diagnostic sensitivity of early lung cancer is not enough to meet the clinical requirements, which restricts the effective implementation of screening methods; imaging detection still has certain limitations and cannot meet the needs of screening. effective, economical and practical means of screening

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lung cancer early screening marker, model construction method, detection device and computer readable medium
  • Lung cancer early screening marker, model construction method, detection device and computer readable medium
  • Lung cancer early screening marker, model construction method, detection device and computer readable medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0049] The terminal sequence of ctDNA fragments in the early stage of lung cancer is affected by the tumor microenvironment, and the specific sequence is more prone to breakage, which is significantly different from the terminal sequence of cfDNA fragments in healthy people. It is very suitable for the liquid biopsy technology based on ctDNA detection. According to the current clinical research data of lung cancer early screening, the sensitivity and specificity of liquid biopsy lung cancer early screening products are both over 90%, which has high clinical value.

[0050] Calculation method in the present invention is described in detail as follows:

[0051] In the present invention, steps such as extraction of cfDNA from blood samples, library construction, and sequencing are firstly required. The extraction and library construction methods here are not particularly limited, and can be adjusted from extraction methods in the prior art. In the sequencing process here, the se...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a lung cancer early screening marker, a detection method, a detection device and a computer readable medium, WGS low-depth sequencing is carried out on plasma sample cfDNA, a sequence 8mer (Motif end8mer) at a breakpoint at the tail ends of differential DNA fragments between lung cancer and healthy people is analyzed according to a high-throughput sequencing result, a model is constructed, and the purpose of noninvasive accurate diagnosis of lung cancer is achieved.

Description

technical field [0001] The invention relates to early screening of non-small-cell Lung Carcinoma (NSCLC), which belongs to the technical field of molecular biomedicine. Background technique [0002] Lung cancer is the malignant tumor with the highest incidence rate in my country, and non-small cell lung cancer is the most common type of lung cancer, accounting for about 80% to 85% of all lung cancer patients. At present, although imaging, serology, genomics, proteomics and other methods have been used to screen suspected lung cancer, there are still problems such as missed diagnosis and misdiagnosis. The early symptoms of lung cancer are relatively insidious and there are no typical symptoms. In the middle and late stages, most patients will develop cough, which is caused by the tumor compressing the bronchus, and the cough of patients is generally not easy to relieve. Without intervention, the tumor will grow unrestricted and the patient's symptoms will gradually worsen. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G16B20/30G16B40/00G16B30/10
CPCC12Q1/6886G16B20/30G16B40/00G16B30/10C12Q2600/178
Inventor 刘睿包华吴雪吴舒雨徐秀秀杨鹏王沙邵阳杨珊珊朱柳青崔月利刘璟文
Owner GENESEEQ TECH INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap