Lung cancer early screening marker, model construction method, detection device and computer readable medium

Abstract

The invention relates to a lung cancer early screening marker, a detection method, a detection device and a computer readable medium, WGS low-depth sequencing is carried out on plasma sample cfDNA, a sequence 8mer (Motif end8mer) at a breakpoint at the tail ends of differential DNA fragments between lung cancer and healthy people is analyzed according to a high-throughput sequencing result, a model is constructed, and the purpose of noninvasive accurate diagnosis of lung cancer is achieved.

Description

technical field [0001] The invention relates to early screening of non-small-cell Lung Carcinoma (NSCLC), which belongs to the technical field of molecular biomedicine. Background technique [0002] Lung cancer is the malignant tumor with the highest incidence rate in my country, and non-small cell lung cancer is the most common type of lung cancer, accounting for about 80% to 85% of all lung cancer patients. At present, although imaging, serology, genomics, proteomics and other methods have been used to screen suspected lung cancer, there are still problems such as missed diagnosis and misdiagnosis. The early symptoms of lung cancer are relatively insidious and there are no typical symptoms. In the middle and late stages, most patients will develop cough, which is caused by the tumor compressing the bronchus, and the cough of patients is generally not easy to relieve. Without intervention, the tumor will grow unrestricted and the patient's symptoms will gradually worsen. ...

AI Technical Summary

Problems solved by technology

At present, the diagnostic sensitivity of early lung cancer is not enough to meet the clinical requirements, which restricts the effective implementation of screening methods; imaging detection still has certain limitations and cannot meet the needs of screening. effective, economical and practical means of screening

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