Near-infrared two-region activated probe and application thereof
A near-infrared and probe technology, applied in the field of nano biosensing, can solve the problems of indeterminacy and easy missed detection, and achieve the effect of accurate detection and high detection sensitivity
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[0069] This embodiment provides an activating probe for the detection of tumor sentinel lymph node metastasis of miRNA 155 highly expressed in breast cancer, including: a first-strand probe, a second-strand probe, a third-strand probe and a fourth-strand probe The needle, as well as the tumor-targeting peptide loaded on the delivery carrier, have targeting properties, imaging and detection functions simultaneously. In an embodiment, the above-mentioned fluorescent materials and nucleic acid sequences are all encapsulated in targeted functionalized modified stem cell vesicles to form an activated probe in the second near-infrared region.
[0070] 1. Preparation of near-infrared activated probes
[0071] (1) DNA chain design: using IDT-OligoAnalyzer TM Tool designs each nucleic acid sequence: fluorescent dye chain (F-DNA), quencher chain (Q-DNA), Linker-DNA, fuel chain (Fuel-DNA) and microRNA 155 (sequences are as SEQID No: 1-SEQ ID No: 5), all designed nucleic acid sequences ...
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