507results about How to "High detection sensitivity" patented technology

A highly reliable electrostatic-capacitive-type display device with a touch panel which allows a user to perform finger touch inputting and exhibits excellent detection sensitivity is provided. A transparent conductive film is formed above a back surface of an electrostatic-capacitive-type touch panel so as to block noises generated by a display device. A conductive member is provided to supply a voltage to a transparent conductive film formed above a back surface of the touch panel. An electrode which is formed on the electrostatic-capacitive-type touch panel is divided in accordance with a ratio between the number of X electrodes and the number of Y electrodes. A floating electrode is formed in a gap defined between the electrodes so as to adjust an area of the electrode. Due to the shrinkage of the area of the electrode, it is possible to lower a noise level to a level equal to or lower than a signal level. Accordingly, an S/N ratio is increased thus enhancing detection sensitivity. Further, lines are branched on a flexible printed circuit board and intersecting lines are formed on a back surface of the flexible printed circuit board, and the intersecting lines are made to orthogonally intersect with lines formed on a front surface of the flexible printed circuit board thus lowering line capacitance.

The present invention provides methods, devices and device components for detecting, sensing and analyzing molecules. Detectors of the present invention provide good detection sensitivity over a wide range of molecular masses ranging from a few Daltons up to 10s of megadaltons, which does not decrease as function of molecular mass. Sensors and analyzers of the present invention detect emission from an array of resonators to determine the molecular masses and/or electric charges of molecules which impact or contact an external surface of a membrane that is used to mount and excite the resonators in the array. Resonators in the array are excited via piezoelectric and/or magnetic excitation of the mounting membrane and, optionally, grid electrodes are used in certain configurations for electrically biasing for the resonator array, and for amplification or suppression of emission from the resonators so as to provide detection and mass/electric charge analysis with good sensitivity and resolution.

A method of sensing an environmental agent, comprising obtaining a sample from the environment and transferring the sample into the working fluid for dispensation to a detection module. The sample and working fluid mixture is filtered through a porous polymer Bragg grating. By comparing the refractive index of the grating with the mixture to the refractive index of a grating without the sample, a difference in the refractive index aids in the identification of a hazardous agent in the environment. The sensor also acts as a chemical filter by trapping specific target agents by a highly specific reaction with a conjugate molecule. Recirculation of the working fluid throughout the system provides a sensor that is “always on.”

In a capacitance detecting circuit, changes in capacitances at intersections between a plurality of row lines and a column line are detected as voltages. The capacitance detecting circuit includes a column-line driver for driving the column line. A code generator generates code having orthogonality in chronological order. A selection synthesizer selects a certain number of row lines from the plurality of row lines by using the code and synthesizes measured voltages at the intersections between the selected row lines and the driven column line so as to output the synthesized measured voltage. A decoding computation unit separates the measured voltages corresponding to the capacitances at the intersections by performing product sum computation between the synthesized measured voltage and the code.

The invention relates to a method for enhancing a Raman spectrum by using shell isolated nano particles, relating to the field of detection of laser Raman spectrums. The invention provides the universal method which has easy and fast preparation, low cost, strong Raman signal, good repeatability and accurate result, and is used for enhancing the Raman spectrum by using the shell isolated nano particles. The method comprises the following steps of: preparing the shell isolated nano particles with nuclear shell structures taking metal nano particles as kernels and extremely-thin shell inert materials as outer shells; uniformly scattering the shell isolated nano particles on the surface of a sample to be measured; and directly detecting the surface enhanced Raman spectrum.

The method comprises: receiving the capacitance value signal outputted from the imbibe probe; according to the variation of the capacitance, outputting the voltage signals corresponding to the capacitance; deciding if the voltage value of current voltage signal is less than a threshold value; if yes, then calculating the gradient of neighboring voltage signals; deciding if the gradient is more than a gradient threshold; if yes, adding 1 in the first fluid level blip counter; if not, subtracting 1 in the first fluid level blip counter; deciding if the first fluid level blip counter value is more than or equals a first preset value; if yes, then outputting the fluid surface touching indication signal.

The invention discloses a quantum dot multicolor marking method for quantitative detection of various cardiovascular disease markers and a kit of troponin I/creatine kinase isoenzyme/myohemoglobin. The method realizes fluorescent quantitative detection by utilizing excellent fluorescent properties of quantum dots and combining a multicolour marking technology and an immunochromatographic assay on the basis of optimizing each component of a test strip. Compared with the common collaurum immunochromatographic assay, the method has the advantages of good mark stability, low nonspecificity, high sensitivity, wide linear range, small cross interference, and accuracy in quantification. The kit disclosed by the invention is used for carrying out quantification detection on the troponin I, the creatine kinase isoenzyme and the myohemoglobin simultaneously, is suitable for detection of whole blood, blood serum and plasma samples, can provide a reference for cardiovascular and cerebrovascular disease diagnosis, and is widely applied to primary hospitals and clinics.

The invention discloses a detection kit for a novel coronavirus, influenzas A and B and a respiratory syncytial virus. According to the detection kit, through combining primer probe design and adaptive detection system optimizing research, a group of nucleic acid combined detection primer and probe combinations and nucleic acid combined detection kits for the novel coronavirus (2019-nCoV/SARS-CoV2), an influenza A virus (FluA), an influenza B virus (FluB) and the respiratory syncytial virus (RSV) are developed, and sequences of primers and probes are shown in SEQ ID NO: 1-18. The kit has theadvantages of high detection sensitivity, good repeatability and low false negative and false positive and can effectively distinguish novel coronavirus infection from ordinary viral influenza and respiratory syncytial virus induced respiratory tract infection, so that precise diagnosis and subsequent precise treatment on a sufferer are achieved.

The invention relates to a method for detecting the welding quality of a hot-melt even joint of a polyethylene pipeline and a detection device thereof. The aim of the invention is that the provided detection method and the detection device have the characteristics of high sensitivity, high detection precision, high reliability, high detection efficiency and low misoperation rate. The technical proposal is a method for the coupling focusing ultrasonic detection of the hot-melt even joint of the polyethylene pipeline, which comprises the following steps: (1) a coupling agent liquid is positioned on the outer surface of a pipeline joint fusion region; (2) an ultrasonic probe adopting a spherical curved wafer is immersed into the coupling agent liquid in order that the focus is positioned in the centerline of the pipeline joint fusion region; and (3) the ultrasonic probe does linear scanning motion along the diameter direction of the pipeline and does uniform scanning motion along the circumferential direction of the pipeline; and obtained signal data is processed by a computer to form a C scanning picture. The ultrasonic detection device comprises a coupling receiving device, the ultrasonic probe adopting the spherical curved wafer, a mechanical scanning device, a signal processing and controlling system, and the computer.

The invention discloses a magnetic microsphere carrier and its making method. The magnetic microsphere carrier adopts a micro or submicron scale magnetic microsphere as a mother sphere, and a nanometer-scale subsphere with the surface having abundant functional groups is assembled on the surface of the mother sphere through chemical cross-linking to obtain the assembled magnetic microsphere having a structured topologic structure. The magnetic microsphere carrier can realize the efficient capture and detection of a target molecule to be detected as a carrier for identifying, capturing and controlling the target molecule to be detected. Compared with traditional smooth spherical magnetic microsphere having same surface functional groups, the magnetic microsphere having a structured topologic structure has the advantages of substantial improvement of the detection sensitivity of the in-vitro diagnosis application process, simple assembly process, structured morphology, great improvement of the microsphere surface area because of the formation of the topologic structure, and guarantee of the efficient fixing of the target biological probe molecule in the subsequent in-vitro diagnosis application process.

Tactile sensors are disclosed that mimic the human fingertip and its touch receptors. The mechanical components are similar to a fingertip, with a rigid core surrounded by a weakly conductive fluid contained within an elastomeric skin. The deformable properties of the finger pad can be used as part of a transduction process. Multiple electrodes can be mounted on the surface of the rigid core and connected to impedance measuring circuitry within the core. External forces deform the fluid path around the electrodes, resulting in a distributed pattern of impedance changes containing information about those forces and the objects that applied them. Strategies are described for extracting features related to the mechanical inputs and using this information for reflexive grip control. Controlling grip force in a prosthetic having sensory feedback information is described. Pressure transducers can provide sensory feedback by measuring micro-vibrations due to sliding friction.

The invention discloses a kit for detecting procalcitonin. The kit comprises a luminous substrate, a magnetic particle coupling antibody, a biotinylation antibody and an enzyme marker, wherein the enzyme marker is horseradish peroxidase labeled streptavidin; and the antibody is a procalcitonin monoclonal antibody. In the kit, the magnetic particle coupling antibody is used as a fixed separation phase, a biotin-streptavidin multistage amplification system is adopted, the luminous substrate is catalyzed by using horseradish peroxidase serving as catalytic enzyme to emit light, and the detectionsensitivity and accuracy of reagents are improved.

The invention discloses N-benzoyl rhodamine B hydrazide, a method for making the same and an application of the same. The structure of the N-benzoyl rhodamine B hydrazine is shown in formula I. Due to having great molar absorptivity and high fluorescence quantum yield, xanthene dye is an excellent matrix of an optical probe. The xanthene dye derivative-N-benzoyl rhodamine B hydrazide can be selectively reacted with hypochlorite to carry out chromogenic and fluorescence opening reaction; therefore, a system with excellent optical performance can be generated by colorless matter; moreover, detection can be carried out through both a light absorption method and a fluorescence method. In addition, when the N-benzoyl rhodamine B hydrazide is used to detect hypochlorite, high detection sensitivity can be obtained and the detection can be completed just through adopting a small amount of samples, thereby broadening the application range of the method.

The detecting device comprises of the reagent strip, the reagent plate, the scanner, the data processing device, the output device and IC card. The reagent strip with the quality control strip and the detection strip being coated is stuck on the reagent plate fixedly. The density and the scanning time are stored on the IC card. With the parameters on the IC card being read out, the data processing device control the scanner to scan the reagent strip and the signals collected are transferred back to the data processing device. After the optical density value of the quality control strip and the detection strip being recognized, calculated and analyzed, the result is transferred to the output device. The invented detecting device provides the quantified detection with the precision and the accuracy accorded with the requirement.

The invention provides a high-sensitivity biological sensor and a preparation method thereof. The high-sensitivity biological sensor comprises a quartz crystal micro-balance, and is characterized in that polymer fibers are deposited on an electrode of the quartz crystal micro-balance, a metal film covers the polymer fibers, a self-assembling material covers the metal film, and the self-assemblingmaterial is connected with a biological sensing material. The preparation method is characterized by comprising the following steps that: dissolving a spinning polymer raw material in solvent to obtain an electro-spinning raw material; electro-spinning the electro-spinning raw material; depositing the spun fibers on an electrode of the quartz crystal micro-balance; spraying a metal film on the fibers; soaking the electrode of the quartz crystal micro-balance into a self-assembling material solution; taking out the electrode of the quartz crystal micro-balance to be dried and to be connected with a biological sensing material so as to obtain the high-sensitivity biological sensor. The high-sensitivity biological sensor has the advantages that the sensitivity is high, and the quantitative detection can be precisely performed.

In order to provide a method for electrochemically detecting an analyte which can detect an analyte with high detection sensitivity, when detecting an analyte S trapped on a working electrode, a label binding substance 90 in which a labeling substance 93 and a first binding substance 92 which traps the analyte S are at least retained on a support 91 composed of polypeptide is brought into contact with the analyte. Alternatively, a complex containing the analyte S and a label binding substance 290 in which a labeling substance 293 is retained on a binding substance 291 which binds to the analyte S via a modulator 292 is formed. Then, the labeling substance present on the working electrode is electrochemically detected.

The object of the present invention is to provide a production process of a microfluidic device in which a porous resin layer, which is capable of optimally fixing a large amount of enzyme, antigen or other protein or catalyst on the inner surface of a minute channel of a microfluidic device without obstructing said channel, is formed at a uniform thickness on the surface of said channel. In the present invention, by preliminarily forming a porous resin layer having a large number of pores in its surface on a substrate, and forming an indentation having a porous resin layer on its bottom surface by using an activating energy beam-curable composition on said porous resin layer, followed by forming a channel by adhering a member serving as a cover to said indentation, a porous resin layer can easily be formed at a uniform thickness on the surface of said channel.

A thermal detector includes: a substrate; a support member supported so that a cavity is formed between the substrate and the support member; a heat-detecting element supported on the support member; a thermal transfer member disposed over the heat-detecting element, and including a thermal collecting portion made of a material having light-reflecting characteristics and having a pattern with which a portion of light incident to a region defined by the support member as seen in plan view enters towards the support member, and a connecting portion connecting the thermal collecting portion to the heat-detecting element; a first light-absorbing layer contacting the thermal transfer member between the thermal transfer member and the support member; and a second light-absorbing layer contacting the thermal transfer member and disposed on the thermal transfer member.

A high-efficiency, high-sensitivity absorbance detection system in a lab-on-a-chip is provided. The absorbance detection system includes detection cells having an optical pathlength ten times and/or much longer than the width of a separation channel to improve detection sensitivity, lens structures for collimating light in the detection cells, and slit structures for preventing scattered light from entering detectors. The detection cells, the lens structures, and the slit structures of the absorbance detection system are fabricated and integrated in a lab-on-a-chip. The absorbance detection system exhibits excellent absorption efficiency, detection limit, and linearity, compared to existing absorbance detection systems, and can be applied for the detection of a variety of samples. The absorbance detection system does not need labeling of the samples which saves time and costs. The absorbance detection system can be used effectively in detecting trace compounds with a high sensitivity. The absorbance detection system in a lab-on-a-chip can be used with wider applications to a variety of samples in diverse research fields, such as the drug screening field dealing with simultaneous synthesis and identification of a number of compounds based on combinatorial chemistry, the life sciences field handling trace bioactive materials such as enzymes, proteins, and amino acids, and the environmental research field which needs rapid field monitoring of contaminants.

The invention discloses an immunochromatographic test strip, a detection method by using the immunochromatographic test strip, and application of the immunochromatographic test strip; the immunochromatographic test strip comprises a conjugate cushion, a testing line and a quality control line; the conjugate cushion is coated with Janus nano-particles marked by a detection antibody; the testing line is coated with a capture antibody or antigen; and the quality control line is coated with an antibody of the detection antibody. On the basis of the Janus nano-particles, double functions including visual read-out and fluorescent read-out of a target object can be realized; compared with a traditional colloidal gold immunochromatographic test strip, for the immunochromatographic test strip, the quantitative detection can be realized; and the relatively high detection sensitivity can be obtained.

The invention discloses a fluorescence chemical sensor for detecting Dam transmethylase. The fluorescence chemical sensor for detecting the Dam transmethylase comprise a Dam transmethylase detection probe and an auxiliary probe; the Dam transmethylase detection probe is a hairpin DNA probe with stem-loop structures; the two stem structures are complemented to form double-chain DNA; the double-chain DNA has an identification site of the Dam transmethylase; the 3' terminal of the hairpin DNA probe is modified by amino; the identification site of the Dam transmethylase is a palindromic sequence of 5'-G-A-T-C-3'; and the auxiliary probe is a T-enriched single-chain DNA sequence with the near 3' terminal with a apurinic pyridine site (AP site). The preparation and detection method of the fluorescence chemical sensor is simple, the detection sensitivity is greatly improved, nonspecific reaction is effectively avoided, and the Dam transmethylase can be detected accurately in a complex biological sample.

The invention relates to a formaldehyde gas sensor, which comprises a substrate, an electrode layer and a gas sensing layer, wherein the substrate is made of insulating materials, the electrode layer is arranged on one side of the substrate, the gas sensing layer is at least made of nickel oxide (NiO) and is arranged on one side of the electrode layer, and the electrode layer is led to be arranged between the substrate and the gas sensing layer, and the thickness of the gas sensing layer is between 0.3 and 0.52mum. The formaldehyde gas sensor can effectively improve detection sensitivity and detection efficiency, which lowers the minimum detection limit and the reaction time.

The invention discloses a helium mass spectrometer leak detection method for a sealing workpiece. The method includes the steps that a first vacuum box is provided, and the sealing workpiece is placed in the first vacuum box; helium is injected into the first vacuum box, and sealing pressure maintaining is performed on the box; the sealing workpiece to be detected is taken out of the first vacuum box; a second vacuum box is provided, and the sealing workpiece taken out is placed in the second vacuum box; the second vacuum box is vacuumized, and vacuum pressure maintaining is performed on the second vacuum box; helium mass spectrometer leak detection is performed on gas inside the second vacuum box. A helium molecule pressing-in and pumping-out detection method is adopted, the method has the advantages of being high detection flexibility and detection accuracy, and the needed helium-containing pressure value is set according to pressure-resistance requirements of a to-be-detected closed container; the higher the pressure is, the higher the leak detection efficiency is; accordingly, the leakage amount of the to-be-detected closed container can be truly reflected, and special tools and fixtures are not needed; multiple workpieces can be detected at the same time to improve production efficiency, and the method can be widely applied to the temperature control pinger industry and the like.

An arrangement for detecting local light irradiation in an illegal attack attempt to intentionally induce a malfunction or faulty condition is formed on a small chip occupancy area so as to provide high detection sensitivity. In a region containing a logic circuit, a plurality of series-coupled detection inverters are distributively disposed as photodetector elements having a constant logical value of primary-stage input. When at least one of the series-coupled detection inverters is irradiated with light, an output thereof is inverted, thereby producing a final output through the series-coupled detection inverters. Based on the final output thus produced, local light irradiation can be detected.

The invention discloses a kit for processing an antigen-antibody immune complex in a serum or plasma sample. The kit is prepared from a meta-acid buffer solution serving as a solvent, high-concentration salt ions, an ionic surfactant, a nonionic surfactant, a reducing agent, urea, trehalose and a defoaming agent. The kit is suitable for processing the serum or plasma sample which is suspected to generate the antigen-antibody immune complex to further influence the antigen or antibody detection result, and the processed serum or plasma sample is suitable for the sample detection, such as enzyme-linked immunoassay and chemiluminescence immunoassay, while the sample which does not generate the immune complex does not affect the normal detection result after being processed via the conditioning fluid of the kit. The kit disclosed by the invention can effectively dissociate the formed antigen-antibody immune complex in the sample, greatly improves the detection sensitivity of the sample, and has a very high clinical application value.

The invention relates to an exosome detecting method based on adapter and rolling ring amplification. An electrochemical sensor method is applied for constructing an adapter probe based on exosome singularity. A signal is generated by means of H2O2 reaction catalysis by G-tetrad-Hemin simulated peroxidase. A large number of G-tetrads are synthesized through rolling ring amplification for performing signal amplification. The method realizes quantitative detection for the exosomes and is used for detecting an actual serum sample. According to the method of the invention, the adapter probe basedon the exosome singularity is constructed through applying an electrochemical sensor method; the signal is generated through H2O2 catalysis by the G-tetrad-Hemin simulated peroxidase; and furthermorea large number of G-tetrads are synthesized through rolling ring amplification for realizing signal amplification, thereby greatly improving detecting sensitivity of the exosome.

The invention discloses a tilapia streptococcus agalactiae IgM antibody capture ELISA detection kit. An anti-tilapia IgM specific monoclonal antibody is secreted from an anti-tilapia IgM hybridoma cell strain 2H5/B5 assigned the accession number CCTCC No:C201277. The kit includes an ELISA plate which is coated by the monoclonal antibody, an antigen tilapia streptococcus agalactiae SIP fusion protein, an IgG-HRP enzyme marker of an SIP fusion protein rabbit polyclonal antibody, an antibody diluent, a washing solution, a coloring reagent, a stop solution, a positive control and a negative control. The anti-tilapia IgM specific monoclonal antibody is high in titer and specificity. The kit is simple in operation, is high in sensitivity, is strong in specificity, can be used in detection of a tilapia streptococcus agalactiae IgM antibody and has a quite high application value.

A detection reagent kit for overall 25-hydroxy-vitamin-D is characterized by comprising a reagent 1, a reagent 2 and a reagent 3; the reagent 1 is dissociation liquid containing surfactant, the reagent 2 is formed by putting antibodies resisting human 25-hydroxy-vitamin-D2 and 25-hydroxy-vitamin-D3 in a proper buffer solution, and the reagent 3 is formed by putting polystyrene latex particles with the surfaces marked with human 25-hydroxy-vitamin-D2 and 25-hydroxy-vitamin-D3 in a proper buffer solution. The reagent kit has the advantages of being high in detection sensitivity and accuracy, good in precision, wide in detection linearity, good in stability, short in detection time and low in production cost.

The invention belongs to the field of biological detection. An aflatoxin M1 immunochromatographic test strip is characterized by comprising a paper board, wherein a water absorption pad, a detection pad, a gold-labeled pad and a sample pad are attached to one side of the paper board in turn from top to bottom, wherein the adjacent pads are overlapped at joints; the detection pad takes a nitrocellulose membrane as a base pad; the nitrocellulose membrane is provided with a transverse quality control line and a transverse detection line from top to bottom; the detection line is coated with an aflatoxin M1-bovine serum albumin (AFM1-BSA) conjugate; the quality control line is coated with a rabbit anti-mouse polyclonal antibody; a nanogold-labeled aflatoxin M1-resistant monoclonal antibody is transversely sprayed on the gold-labeled pad; and the aflatoxin M1-resistant monoclonal antibody is produced by a hybridoma cell strain 2C9 with the collection number of CCTCCNO.C201018. The test strip is used for detecting aflatoxin M1 and has the characteristics that: the test strip quickly detects the aflatoxin M1, is easy to operate and has high sensitivity.

The invention relates to a method for diagnosing a transmissible spongiform subacute encephalopathy (TSSE) caused by an unconventional transmissible agent (UTA) or prion. The method involves treating a sample suspected of containing a prion with proteinase K for a time and under conditions that completely degrade normal prion protein (Prp-sen), but which only partially digest abnormal prion protein (PrP-res) so that all or some of the octapeptide motif repeats comprising P(H/Q)GGG(-/T)WGQ (SEQ ID NO: 1) in the abnormal prion protein (Prp-res) are retained.