358 results about "Biological target" patented technology

Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.

The invention provides hollow-tip-electrodes for spatially localized delivery of substances to one or more biological targets present in a population comprising target and non-target molecules, macromolecules, and / or cells. The invention also provides electrode plates for receiving one or more of such tips, tip-electrode plates comprising electrode plates comprising one or more electrode tips, and systems comprising tip-electrodes and containers for containing one or more biological targets, e.g., such as molecules, macromolecules, and / or cells. The invention further provides methods for using such systems and components thereof. In one preferred aspect, the systems are used for spatially confined electroporation of cells and cell structures. The invention facilitates high throughput screening of agents (e.g., such as drugs) that act on intracellular targets.

The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified. In preferred embodiments, such identification can be made simultaneously with libraries of ligands.

The invention provides compositions and methods for the detection and / or quantification of biological targets (e.g., nucleic acids and proteins) by the nucleic acid-templated creation of one or more reaction products, for example, epitopes, enzyme substrates, enzyme activators, and ligands. The reaction products can be detected and / or quantitated after signal amplification using an amplification system.

The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and / or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion / solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.

A system and method for target classification for an aircraft surveillance radar is provided. In one implementation, the track classifier provides tracks with an updated probability value based on its likelihood to conform to aircraft and non-aircraft target behavior. The track classifier identifies false tracks that may arise from weather and biological targets, and can detect aircrafts lacking Secondary Surveillance Radar (SSR) data. Various features and combinations of features are evaluated using a proposed clustering performance index (CPI) and used to discriminate between aircrafts and false tracks.

The invention provides hollow-tip-electrodes for spatially localized delivery of substances to one or more biological targets present in a population comprising target and non-target molecules, macromolecules, and / or cells. The invention also provides electrode plates for receiving one or more of such tips, tip-electrode plates comprising electrode plates comprising one or more electrode tips, and systems comprising tip-electrodes and containers for containing one or more biological targets, e.g., such as molecules, macromolecules, and / or cells. The invention further provides methods for using such systems and components thereof. In one preferred aspect, the systems are used for spatially confined electroporation of cells and cell structures. The invention facilitates high throughput screening of agents (e.g., such as drugs) that act on intracellular targets.

Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and / or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.

The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and / or for a controlled melting of hybridizations. The reactant (10) and / or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.

A modular system for optical diagnosis of a sample includes a portable optical probe, a light source, a filter, and a gain detector. A first optical element releasably, optically couples the optical probe to the light source. A second optical element releasably, optically couples the optical probe to the filter and a third optical element releasably, optically couples the filter to the gain detector. The optical probe receives an optical signal from the light source via the first optical element and directs the optical signal onto the sample, thereby inducing fluorescence emission from the sample. The optical probe receives the fluorescence emission from the sample and transmits to the filter via the second optical element. The filter transmits the fluorescence emission to the gain detector via the third optical element. The optical head includes a beam splitter which reflects the fluorescence emission from the sample to the filter.

The invention discloses an intelligent optimization method of a tumour radiotherapy plan. The method includes: 1) intelligent delineation of a biological target region, biological sub-target regions and a multi-modal(mode) image fusion target region of a tumor PET image, wherein an intelligentized image analysis processing method is adopted to delineate the biological target region, the biologicalsub-target regions and the multi-modal image fusion target region of a tumor according to multi-modal image information such as tumor PET / CT / MRI / CBCT / ultrasound; 2) optimization calculation of optimal prescription doses of biological intensity modulated tumor radiotherapy, wherein the optimal prescription dose of each biological sub-target region is determined through the intelligentized and automated optimization method according to biological characteristics of the tumor; and 3) tumor clinical-radiotherapy plan big-data analysis-based optimization calculation of the multi-objective radiotherapy plan, wherein the 1) and the 2) are combined to determine the self-adaptive biological intensity modulated clinical precise tumor radiotherapy plan of multi-objective optimization through an intelligent big-data analysis method and a deep learning, machine learning or artificial intelligence method according to clinical tumour radiotherapy plan data.

The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and / or chromophoric signals.

The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.

The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1') of a complentary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) is characterized in that the chemical compound further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m') of a similar chemical compound comprising a chemical moiety (q). The invention comprises corresponding libraries of chemical compounds as well as methods of biopanning of target molecules and of identifying such targets.

The present invention provides pharmacological compounds including an effector moiety conjugated to an binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

The present invention relates to two-dimensional photonic crystal arrays and their use in biological sensor chips, including those in the form of microfluidic devices. Methods of making the two-dimensional photonic crystals and biological sensor chips are described herein, as are uses of these devices to detect biological targets in samples.

The invention concerns a method and device for needle-less delivery of substances into or through natural or artificial biological components such as membranes, organelles, cells, tissues, organs, or creatures, by exposing the said biological components to accelerated substances wherein high impact mechanical movement over short distance is used to create acceleration of substances so to drive substances into or through said natural or artificial biological components, while isolating the biological component from the driving force. The mechanical movement is preferably created by an ultrasonic member having a high repetition rate, and the space between accelerating element and biological target is preferably composed of low density compound. The delivery device can be provided with a unit for supplying substance to be delivered, to the mechanical accelerating element. The device can be constructed either as delivery device for superficial tissues, or as an endoscopes laparoscope-like or catheter-like device for delivery in minimally invasive procedures.

The present invention discloses a cancer-related genes finding method by using miRNA expression data, based on a pan-cancer program PanCancer under The Cancer Genome Atlas (TCGA), and uses statistical analysis and a machine learning algorithm to carry out analysis and processing on the gene expression data, and to identify complex diseases related genes. The method comprises: sorting out sample data; carrying out statistical analysis on the miRNA expression data; sorting miRNA in order of an average change rate; selecting a target gene; extracting a corresponding disease sample and normal sample; and using a Relief algorithm to sort genes in the extracted miRNA sample. The method disclosed by the present invention can find a plurality of risk genes related to cancer and other complex diseases, and has important significance to a biological target therapy, biomedical research, pathogenesis explanation, risk prediction, and the like.

A catheter system with an enhanced steering system, allowing for positioning the distal portion of the catheter proximate to a desired biological target tissue site, is provided. The system includes an elongated tubular member having a steerable distal end configured to deflect, or otherwise direct, and properly position at least a portion of the distal end comprising an ablation device during a surgical procedure allowing for the placement of the deflected portion adjacent or proximate to the target tissue surface. The steering system may alternatively be incorporated into a separate guiding catheter as part of the catheter system.

Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.

The invention is related to a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, a complex that comprises a biotinylated bacteriophage and a biotin-specific ligand conjugated bioconjugate, and a method of detecting a bacterial cell in a sample comprising contacting the sample with a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, wherein the bacteriophage is specific to the bacterial cell.

The utility model relates to a biosensor, which utilizes the specific identification of the aptamer on target biomolecule and the changes in the electric conductance property of organic productive polymerization caused by the aptamer to do detection on the biological target quantitatively. The microelectrode of the biosensor comprises a working electrode and a counter electrode; wherein, the working electrode or the counter electrode respectively comprises a plurality of electrode wires, which are the same in number and in relative array, an in situ synthesized aptamer decorated organic conductive polymerization film or nano-wire is connected between the electrode wires of the working electrode and the electrode wires of the counter electrode, and the working electrode and the counter electrode are connected with a conductor respectively. By detecting changes in the electric conductance property of the organic productive polymerization caused by the specific combination of the target biomolecule and the aptamer on the organic conductive polymerization which is fixed between the microelectrode pairs, the utility model gets the quantitative response to the bio-macromolecules, such as the target protein, directly and fast, and avoids the complex and time consuming marking and incubation in the traditional method.

Sensing device and method for detecting presence and concentration of generic target analytes of interest. The device and method are based on detecting changes in effective dielectric induced by the target analytes of interest. Applications of the invention include, but are not restricted to, detecting and characterizing the presence of chemical and / or biological target analytes of interest as well as detecting and characterizing target analytes of interest from a separation apparatus. In one embodiment of the invention, the device comprises at least two electrodes in a rigid architecture such as a solid surface, where the electrodes have sizes and inter-electrode spacings that are on the order of sizes of target analytes of interest to improve sensitivity of the device. Changes in effective dielectric and, therefore, capacitance induced by a presence of the target analytes of interest are measured electronically. The changes are used to detect the presence of the target analytes of interest and to characterize their presence.

A system and method for target classification for an aircraft surveillance radar is provided. In one implementation, the track classifier provides tracks with an updated probability value based on its likelihood to conform to aircraft and non-aircraft target behavior. The track classifier identifies false tracks that may arise from weather and biological targets, and can detect aircrafts lacking Secondary Surveillance Radar (SSR) data. Various features and combinations of features are evaluated using a proposed clustering performance index (CPI) and used to discriminate between aircrafts and false tracks.

An irradiation device for irradiating a living organism with electromagnetic radiation in order to influence biological structures inside the organism has a frequency generator that has a frequency synthesizer for the production of electromagnetic radiation having a defined frequency pattern, and a transmission antenna that is fashioned such that during operation the electromagnetic radiation is emitted essentially into a particular radiation volume. In addition, the irradiation device has an interface for acquiring structure-specific data for identifying a biological target structure that is to be influenced, a frequency pattern storage unit in which defined resonant frequency patterns allocated to various biological structures are stored, a frequency pattern selection unit for selecting a resonant frequency pattern from the frequency pattern storage unit on the basis of the acquired structure-specific data, and a control unit for controlling the RF generator in such a way that a subject to be irradiated, situated in the radiation space, is exposed to electromagnetic radiation having the selected resonant frequency pattern at a particular intensity and for a particular duration of irradiation.

A decoy inactive carrier composition is administered simultaneously with a targeted composition containing vehicles for delivering a desired agent to a biological target. This simultaneous administration enhances the delivery of the targeted composition to the desired location in a subject.

The invention discloses a sandwich-structured nanometer catalytic material. The sandwich-structured nanometer catalytic material is characterized by taking magnetic Fe3O4 nanospheres as a core, nanometer noble-metal particles as an intermediate phase and cerium-titanium composite oxides as a shell, and the nanometer noble-metal particles are selected from one of Au, Pd and Pt. The invention further provides a preparation method of the sandwich-structured nanometer catalytic material. The preparation method includes sequentially preparing the magnetic Fe3O4 nanospheres, a magnetic noble-metal composite microsphere solution, a magnetic noble-metal composite noncrystalline cerium-titanium-silicon material and a magnetic noble-metal composite crystalline cerium-titanium-silicon material, removing SiO2 through an alkali liquor, separating, washing and drying so as to obtain the sandwich-structured nanometer catalytic material high in catalysis activity and thermostability and excellent in magnetic reclaim performance. Reactants can be in full contact with activated noble metal layers through porous passages in the outer oxide shell. The sandwich-structured nanometer catalytic material has a promising application prospect in the fields of biological target therapy, optical nanometer devices, water-gas shift and olefin gas-phase epoxidation.