22 results about "Optical diagnosis" patented technology

The invention relates to the technical field of space irradiation environment simulation based on ultra-short and ultra-strong laser, and discloses a space irradiation environment simulation device and method based on ultra-short and ultra-strong laser. The device comprises a laser compression cavity, a laser focusing and optical diagnosis system, a primary target system, a secondary conversion target system, a beam sorter, an ion transport system, an electron transport system and a test target holder system. The multi-particle synchronous irradiation device has the beneficial effects that the interaction between the laser pulse and the target material is accurately controlled, so that high-energy ion beams, electron beams and other various particles can be generated, and multi-particle synchronous irradiation is successfully realized. The synchronous irradiation capability enables the experiment to simulate a complex irradiation environment in the space more truly, further reveals the interaction and synergistic effect among a plurality of particles, and overcomes the limitation that a traditional large accelerator can only simulate a single environment.

The invention provides an axial staged rotational flow combustion device, an airflow flow calculation method and an optical diagnosis method. The axial staged rotational flow combustion device comprises the axial staged rotational flow combustion device, a laser generating device and an optical image capturing device. The laser generating device comprises a laser generator and a laser attenuator; the axial staged rotational flow combustion device comprises a primary premixing cavity, a rotational flow premixing cavity, a staged optical combustion chamber and a tail gas discharger which are sequentially arranged from the gas inlet end to the gas exhaust end. The laser generator and the laser attenuator are arranged on the two sides of the grading optical combustion chamber respectively, and the connecting line of the laser generator and the laser attenuator is a light path of planar laser. The optical image capturer is arranged in the vertical direction of the light path and used for capturing spatial distribution information of excited free radicals in a flame field of the grading optical combustion chamber. The purposes that combustion flames are generated based on the axial staged rotational flow combustion device, and spatial distribution information of excited-state free radicals in a flame field is captured through the laser generation device and the optical image capture device are achieved.

The present application relates to the technical field of cancer detection, in particular to a kind of tumor imaging guided photodynamic therapy reagent.The reagent is named ADS254BE / H2TPP NPs, which is composed of hydrophobic conjugated polymer ADS254BE and tetraphenylporphyrin H2TPP doped polymer microspheres, and the surface of the polymer microspheres also has PSMA modification layer.The reagent is prepared by uniformly mixing ADS254BE, H2TPP and PSMA solution, ultrasonic treatment, room temperature standing, and then evaporating solvent in the solution.The photodynamic diagnosis and treatment reagent provided by the present application shows bright red emission centered at 650nm, relatively large stoke shift, higher singlet oxygen generation rate, and good light stability and biocompatibility.The present application provides a feasible strategy for constructing new optical diagnosis and treatment integrated reagent, and is expected to promote the development of imaging guided photodynamic therapy.

The invention discloses an A-D-A type NIR-II multi-mode optical diagnosis and treatment agent with multi-mode imaging guiding and photodynamic-photo-thermal synergistic treatment functions as well as a preparation method and application of the NIR-II multi-mode optical diagnosis and treatment agent. The NIR-II multi-mode optical diagnosis and treatment agent comprises a compound as shown in a structural formula I, or pharmaceutically acceptable salt, solvate and tautomer of the compound. According to the NIR-II multi-mode light diagnosis and treatment material, multi-mode imaging guidance and the photo-thermal-photodynamic effect are combined, many limitations in the prior art can be overcome, efficient diagnosis and treatment of diseases such as tumors and inflammation are achieved, and then development of the multi-mode diagnosis and treatment technology is promoted.

The present application relates to the technical field of high-voltage discharge plasma, and provides a high-voltage discharge plasma element detection device, which comprises an optical platform, a discharge reaction unit, an electrical diagnosis unit and an optical diagnosis unit; the discharge reaction unit, a fiber displacement stage and an ICCD displacement stage are installed on the optical platform; the discharge reaction unit comprises a sample carrier, a supporting component, a ground electrode and a high-voltage electrode; the sample carrier is arranged on the supporting component, and the center of the sample carrier is provided with a small hole; the ground electrode is installed at the root of the optical platform and is grounded, and the needle tip of the ground electrode faces the center of the sample carrier; the high-voltage electrode is arranged above the small hole of the sample carrier, and a plurality of groups of radiating fins are installed on the high-voltage electrode; the discharge reaction unit is connected in series with a parameter adjustment dark box, and the parameter adjustment dark box is connected with a high-voltage alternating current power supply; and the present application can realize accurate regulation and control of the discharge mode and detection of metal elements in solids.

The application discloses an experimental system for analyzing combustion of aluminum powder with different concentrations, and belongs to the field of aluminum powder combustion experiments.The application comprises a multi-element diffusion flat flame burner, an aerosol generator and an optical diagnosis system.The multi-element diffusion flat flame burner and the aerosol generator are placed in a high-pressure bin, and gas paths are connected.The high-pressure bin is closed, combustion gas is introduced from the lower part of the burner, oxidizing gas is introduced from the upper part of the burner, mixing is carried out in a capillary, and the capillary mouth is reached.The multi-element diffusion flat flame burner simulates the high-temperature gas phase environment and component atmosphere in a real combustion device through gas distribution, carries out particle ignition and combustion characteristic test through central supply of aerosol, and has good optical visualization conditions.The aerosol generator is used to generate relatively uniform monodisperse aluminum powder aerosol from a powder generator without using a vibration device.The optical diagnosis system obtains temperature information of combustion through various means, carries out comparison, and increases accuracy of experimental data.

The invention discloses a polymer photosensitizer, nanoparticles and a preparation method and application of the polymer photosensitizer and the nanoparticles, and belongs to the technical field of biological optical diagnosis and treatment. The polymer comprises SPI and FPI, and SPI nano particles and FPI nano particles are prepared from the polymer. Under the irradiation of low-power laser, the SPI nano particles and the FPI nano particles can generate I-type active oxygen, and have excellent near-infrared two-region fluorescence emission performance. The preparation of the near-infrared two-region fluorescence imaging guided low-power laser triggered photodynamic therapy reagent is realized, a new method is provided for developing a low-power efficient photosensitizer, and the near-infrared two-region fluorescence imaging guided low-power laser triggered photodynamic therapy reagent has a potential application prospect in the field of biomedicine.

The application discloses a method for identifying a soot formation critical point in a premixed stable stagnation flame. The method is verified by taking ethylene premixed stable stagnation flame as an example, and the soot formation critical point is identified by using the method. The method collects a large number of flame pictures under each equivalent ratio by a non-invasive optical diagnosis system, and the images are processed by using python. The method provides an error index for judging the influence degree of the number of pictures on the result, quantifies the soot formation process, gives the definition of the soot critical point, and provides an innovative identification index. It is verified by experiments that the method can accurately capture a series of changes of the soot formation region of the premixed stable stagnation flame, and then identify the soot formation critical point.

The invention relates to an electrical connector for transmitting an electrical power signal on an electrical power line (210), the electrical connector comprising an electrical contact configured to be connected to the electrical power line (210) and an optical contact (11) configured to be connected to an optical diagnosis line (103). The invention further relates to an electrical connection system (100) comprising an assembly of electrical connectors (1a, 1b). The invention also relates to an electrical connection network for an aircraft, the electrical connection network comprising the electrical connection system (100).

An optical diagnosis system for ignition of single-particle excavate waste includes: an excavate waste combustion device, an excavate waste feeding device, an oxidant supply device, a flow monitoring device, an observation device and a flue gas analysis device. The excavate waste feeding device cooperates with the excavate waste combustion device, the oxidant supply device is connected to the excavate waste combustion device via the flow monitoring device, the flue gas analysis device is connected to the excavate waste combustion device, and the observation device cooperates with the excavate waste combustion device. Excavate waste particles are automatically conveyed by a slide rail bracket, and particles are prevented from falling off due to thermal expansion by adopting a hoisting tray. A flow stabilizing plate is added at a bottom of the combustion device, and the captured image is processed to achieve high-precision judgment of the ignition moment.

The application provides an oil bubble discharge experiment platform comprising an optical diagnosis system, realizes quantitative research on bubble discharge characteristics of transformer oil under different parameters, and can observe clear images in a bubble discharge process, and the experiment platform comprises: a power supply system for power supply, wherein the power supply system comprises a test transformer, a protection resistor and a fast protection module; an experiment cavity for containing transformer oil; an electrode system installed in the experiment cavity and used for constructing a uniform electric field oil gap or a non-uniform electric field oil gap; a bubble generating system used for adding bubbles to the oil gap; a partial discharge detection system used for collecting partial discharge signals and analysis; and an optical diagnosis system used for observing the bubble discharge process of the oil gap in the experiment cavity; wherein the partial discharge detection system is further connected with the fast protection module, and is used for outputting signals to the fast protection module when a discharge or breakdown event occurs, so that the power supply system is cut off by the fast protection module.

The application discloses an organic small-molecule optical diagnosis and treatment reagent, nanoparticles and a preparation method and application thereof. The organic small-molecule optical diagnosis and treatment reagent has high near-infrared second region fluorescence brightness, good photo-thermal conversion effect and can generate type I active oxygen. The nanoparticles have good water solubility and biocompatibility, excellent near-infrared second region fluorescence imaging capability, type I photodynamic and photo-thermal conversion performance. Under single near-infrared laser excitation, the nanoparticles can be used for preparing a type I photodynamic / photothermal combined treatment reagent under the guidance of near-infrared second region fluorescence imaging, and have good application prospect.

The invention discloses a method for measuring the transient temperature of a wall surface in a diesel oil impingement combustion process, which comprises an optical diagnosis experiment and simulation calculation, and aims to solve the problems of low response speed, single measurement range, interference on a temperature field and the like in the traditional contact type temperature measurement technology. And the defect that the temperature of the inner wall surface in the combustion duration is difficult to measure in an infrared temperature measurement technology is overcome. The implementation process comprises the following steps: building a constant-volume combustion experiment bench, and carrying out an optical diagnosis experiment of diesel impingement combustion characteristics by adopting a two-color method temperature measurement technology and an infrared temperature measurement technology; processing a two-color method temperature measurement image and an infrared temperature measurement image obtained by an experiment to obtain flame transient temperature data and wall surface transient temperature data under a non-combustion condition; building a diesel impingement combustion process simulation calculation model, and simultaneously calibrating the calculation model by using flame temperature data and wall surface temperature data under a non-combustion condition; and carrying out computational fluid mechanics simulation calculation based on the calibrated model to obtain the wall surface transient temperature under the combustion condition.

The invention discloses a femtosecond time resolution multi-exposure imaging system and a femtosecond time resolution multi-exposure imaging method for observing gas nucleus evolution near a material plate, and belongs to the technical field of ultrafast optical diagnosis. A single pulse emitted by a femtosecond laser light source is subjected to passive beam splitting through a transparent medium sheet queue, and a femtosecond multi-pulse probe cluster is generated; the formation of a gas nucleus is induced near a material interface through a gas nucleus inducing device, and the time sequence of the multi-pulse probe cluster, the formation of the gas nucleus and the exposure of the photosensitive element is accurately controlled by utilizing a synchronous control module; after analysis of the data processing and analysis module, femtosecond-level dynamic information of the whole process of gas nuclei near the material from primary generation, evolution to collapse can be obtained. The ultra-high time resolution is achieved through a simple and low-cost system, an effective means is provided for fine diagnosis of the ultra-fast transient process in the gas nucleus and material interaction, and the method has important application value in the fields of cavitation erosion mechanism research, high-performance material testing, hydraulic machinery and the like.

This invention relates to the field of optical imaging. More specifically, it relates to fluorescent probes capable of effectively targeting prostate-specific membrane antigen (PSMA) and comprising heptamethrin dye having near-infrared (NIR) emission. The invention also relates to methods for preparing these compounds, pharmaceutical compositions and kits for introducing these compounds, and methods for using them as optical diagnostic agents in the imaging or treatment of diseases, particularly prostate cancer.

The invention belongs to the technical field of combustor testing, discloses a testing system of an activated ammonia gas combustor, and aims to solve the problems that a traditional system is insufficient in real-time monitoring and quantification of key parameters in the activated ammonia gas combustion process, a coupling mechanism of activation parameters, a flow field and chemical reaction kinetics is difficult to reveal, and performance improvement is hindered. The system is characterized by comprising a fuel air supply control unit, an activation module, a combustor test cavity, an optical diagnosis system, a thermodynamic monitoring unit, an exhaust analysis pollutant monitoring unit and a data acquisition and processing control system. By the adoption of the technical scheme, comprehensive, real-time and high-precision monitoring of key parameters in the whole combustion process can be achieved, complex coupling of activation parameters and a combustion mechanism is revealed, and accurate guidance is provided for optimization.

The invention discloses a real-time multi-mode optical diagnosis system for oral mucosa diseases and application. The system comprises a dual-channel dual-light-source module, an integrated handheld optical fiber probe, a dual-channel signal acquisition module, a central control module and a signal processing and man-machine interaction module, the dual-channel dual-light source module is used for generating and switching diffuse reflection detection light and Raman excitation light; the integrated handheld optical fiber probe is used for projecting exciting light to skin tissue and collecting diffuse reflection and Raman scattering signals from different depths; the dual-channel signal acquisition module is used for acquiring diffuse reflection signals and Raman scattering signals in parallel; the central control module is used for coordinating synchronous control of light source switching, signal acquisition and data transmission; the signal processing and man-machine interaction module is used for carrying out real-time demodulation, fusion analysis and visual output on the collected signals; according to the method, diffuse reflection parameters and deep Raman information of the tissue surface layer are synchronously obtained in single detection, and non-invasive, in-vivo and layered evaluation of oral mucosa lesions is realized.

The invention belongs to the technical field of scramjet engine ground test optical diagnosis, and discloses a scramjet engine experiment table component-pressure field depth coupling monitoring method, which comprises the following steps: when an experiment table is adjusted to a test working condition, constructing a single-wavelength laser-component response matrix; when the experiment table is adjusted from a test working condition to an experiment working condition, exciting a flow field and a wall surface pressure sensitive coating by using a single-wavelength excitation light source, and collecting component fluorescence intensity signals of different wavebands to form a fluorescence intensity observation vector and a coating light-emitting signal; according to the response matrix, performing inversion calculation on the fluorescence intensity observation vector to obtain content information of each target component including oxygen; calculating pressure information of the monitoring position by using the oxygen component content information, and outputting the component content information and pressure distribution of the monitoring position. And the accuracy and the reliability of component and pressure measurement of the experiment table are improved.

The invention discloses a tumor blood vessel blocking type light diagnosis and treatment reagent and a preparation method thereof.The preparation method comprises the steps that in the nitrogen atmosphere, aza-BODIPY molecules NBDP and a blood vessel blocking reagent 5, 6-dimethylxanthine-4-acetic acid are dissolved in a dichloromethane medium; the light diagnosis and treatment molecule NVDA is obtained through a reaction by taking NVDA as a substrate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) as a carboxyl activating reagent and 4-dimethylaminopyridine as a reaction catalyst. The optical diagnosis and treatment reagent NVDA nano-particles can selectively destroy tumor blood vessels and realize high-resolution blood vessel NIR-II fluorescence imaging so as to dynamically monitor the damage process of the tumor blood vessels; under the irradiation of 808 nm laser, the NVDA nanoparticles can efficiently generate I-type active oxygen species, and also show the photothermal conversion efficiency as high as 44%; the NIR-II fluorescent imaging-mediated I-type photodynamic therapy, photothermal therapy and vascular disruption combined therapy for deep tumor tissues can be used for efficiently killing tumor cells.

The application discloses an assembly synergistic near-infrared two-region nanoparticle based on an electron-rich polymer and a preparation method and application thereof, and belongs to the technical field of precise optical diagnosis and treatment of major diseases such as tumors, and proposes an assembly synergistic strategy, takes an electron-rich block polymer as a carrier, forms an intermolecular electron donor-electron acceptor unit between the carrier and a near-infrared two-region molecule, reduces the singlet and triplet energy level difference of the molecule, promotes inter-gap crossing, effectively inhibits molecular vibration, and thus improves the diagnosis and treatment performance. Compared with a traditional performance optimization method at the molecular level, the application adopts a simple and easy self-assembly strategy, successfully overcomes the problems of low active oxygen yield and low fluorescence quantum yield of the near-infrared two-region optical diagnosis and treatment material, can provide a new and effective means for the precise diagnosis and treatment of major diseases such as tumors, and has a wide application prospect.

The invention relates to the technical field of internal combustion engines, in particular to a jet-induced methanol spray combustion system optical diagnosis device and a test method thereof, and the methanol spray combustion system optical diagnosis device comprises a methanol supply unit, a constant volume bomb combustion unit, an optical diagnosis unit, a data acquisition and control unit and an air supply unit. Wherein the constant volume bomb combustion unit comprises a constant volume bomb, a second methanol ejector, a spark plug, a glow plug, a pre-combustion chamber, a first methanol ejector, an exhaust electromagnetic valve and a constant volume bomb heating unit. The optical diagnosis unit comprises a first digital high-speed camera, a second digital high-speed camera, a first band-pass filter, a second band-pass filter, a high-speed stroboscopic LED light source, a first window, a second window, a diffusion sheet, a convex lens and a spectroscope. Synchronous high-frequency acquisition of a liquid-phase spray image and a flame image of the pre-combustion chamber jet flow induced methanol spray diffusion combustion system is realized.

The invention discloses a quinoxaline-based organic boron dye as well as a preparation method and application thereof. The structural formula of the quinoxaline-based organic boron dye has two spatial isomers, namely a cis (synn-) spatial isomer and a trans (anti-) spatial isomer; the dye is obtained by coordinating a novel N, O-type chelating skeleton constructed based on 2, 3-dihydrazinoquinoxaline and an aromatic aldehyde compound with a boric acid derivative, a one-pot two-step method is adopted, and the dye has the advantages of being simple and convenient in synthesis route, free of complex purification, high in substrate applicability, easy to produce on a large scale and the like. The quinoxalinyl organic boron dye shows excellent photophysical properties, the Stokes shift generally exceeds 100 nm, and fluorescence self-absorption interference is effectively reduced; meanwhile, the fluorescent probe has high molar absorption coefficient, high fluorescence quantum yield and excellent light stability, and has potential application value in the fields of biological imaging, optical sensing, light diagnosis and treatment and the like.