91 results about "Optical diagnosis" patented technology

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

The invention relates to a multi-mode non-linear optical microscopy imaging method and device. The multi-mode non-linear optical microscopy imaging device mainly comprises a laser system, an optical scanning microscope and a non-linear optical signal detecting and acquiring system. The multi-mode non-linear optical microscopy imaging device can work in a single-laser-beam mode and a dual-laser-beam mode and can realize multi-mode non-linear optical microscopy imaging such as two-photon excited Fluorescence (TPEF) imaging, multiphoton high-order harmonic (such as second harmonic generation SHG, and third harmonic generation THG) scattering imaging, coherent Raman scattering (such as anti-Stokes CARS) microscopy imaging) on isolated biological tissues and living cells, so that various non-linear specific optical signals of biological tissue samples can be obtained in situ, so that the important basis is provided for the optical diagnosis and deep analysis of the samples. Besides, a reflection measurement manner disclosed by the invention can be further directly applied to the acquiring of various non-linear specific optical signals of live animals and the microscopy imaging.

The invention provides optical switching-based systems and methods for catheter-based optical diagnosis which are particularly well suited to determining the condition of blood vessels, including the state of the vessels with respect to atherosclerosis and its development. Various embodiments provide catheter-based spectroscopic systems that are configured to cycle between different optical interrogation techniques such as Raman spectroscopy, optical coherence tomography and time-resolved laser-induced fluorescence spectroscopy. One embodiment of the invention provides an intravascular catheter-based diagnostic system that cycles between fingerprint region (200-2,500 cm⁻¹) Raman spectroscopy and high-wavenumber region (2,500-4,000 cm⁻¹) Raman spectroscopy.

An optical diagnosis and treatment apparatus includes a pulsed light source, an illumination optical system for illuminating a region of a living body through a guide tube, a light condensing means for condensing pulsed light, an optical scan means for two-dimensionally scanning the region, a light detection means for detecting the pulsed light reflected from the region, an operation means for reconstructing, based on an output from the light detection means, a tomographic image of the region, an image display means for displaying the tomographic image based on an output from the operation means and a light intensity switching means for switching the intensity of the pulsed light at least between two levels. The two levels are a level at which vaporization of living body tissue due to multi-photon absorption occurs at a convergence position of the pulsed light and a level at which vaporization does not occur.

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

The invention relates to a different modal molecular vibration spectrum detection and imaging device and a method. The device mainly consists of related apparatuses of functional units such as a laser unit, an optical scanning microscopic unit, a stimulated Raman scattering signal probing and acquiring unit and a spontaneous Raman spectrum detection member and the like. In light of implementation by the method, two different modal molecular vibration scattered signals are quickly acquired in situ on a living cell, an isolated biological tissue and a living small animal: spontaneous Raman spectrum detection under a single laser beam working mode and stimulated Raman scattering microimaging under a double laser beam working mode to achieve quantitative microimaging and qualitative spectral analysis on a target so as to obtain characteristic information of target components, thereby providing important data for optical analysis and deep analysis of a sample.

The invention provides a multi-window multifunctional gas and dust explosion inhibition experiment system, and aims to meet a high-transparency quartz window characterized in that a plurality of external triggering connectors are available for externally connecting devices and a plurality of advanced optical testers are synchronously used, and to achieve a comprehensive explosion experiment testing system for preparing multiple gases. The multi-window multifunctional gas and dust explosion inhibition experiment system comprises a testing control system, an explosion container, an ignition system, a gas distribution system, a powder spraying system, a vacuuming system, a heating constant-temperature system as well as at least two optical diagnosis windows, an ignition external triggering connector and a powder spraying external triggering connector, wherein the ignition system is connected with the explosion container; the optical diagnosis windows are formed in side surfaces of the explosion container; the ignition external triggering connector is arranged on an energy-adjustable high-pressure pulse igniter; the powder spraying external triggering connector is arranged on a system testing and control main machine.

The invention specifically relates to a gas, dust explosion and explosion suppression experiment system applicable to various optical diagnosis methods, solving the problems of an existing combustible gas, dust explosion and explosion suppression experiment system that the visibility is low, combustible gas explosion/explosion suppression propagation properties only can be tested from a macroscopic level, and application of an advanced optical measurement technology cannot be met. The experiment system comprises an explosion pipeline, a vacuum-pumping system, a gas distribution system, at least two powder spraying systems and an ignition system, and further comprises a planar laser-induced fluorescence system and a main control system. The invention provides the gas, dust explosion and explosion suppression experiment system applicable to the various optical diagnosis methods, which can be combined with a device for disclosing combustion explosion/explosion suppression propagation properties by microcosmic/macroscopic parameters and takes a steel framework and high-light-transmittance quartz glass as a main body structure.

The invention discloses a small gas-gas injection optical transparent combustion device and suitable for the field of multi-optical diagnosis technology. The combustion device comprises a combustion chamber head cavity, a transparent combustion chamber and a combustion chamber tail. The transparent combustion chamber is fixed between the combustion chamber head cavity and the combustion chamber tail by four uniformly distributed screws. Two ends of each of the screws are cooperatively connected with one hexagonal nut A and one hexagonal nut C so as to impose pretightening force on the transparent combustion chamber, thereby achieving sealing requirements in the transparent combustion chamber. Hexagonal nuts B are cooperatively connected to the screws under a combustion chamber pressing cover and are used for supporting the combustion chamber pressing cover. The transparent combustion device performs comprehensive detection for combustion states, and helps people to deep research combustion mechanism. According to the similarity principle of combustion, research principles of combustion mechanism in a low pressure environment are established, so combustion condition in a high pressure condition can be predicted.

The invention relates to a fluorescent Monte-Carlo simulation method based on cluster-type GPU (Graphic Processing Unit) acceleration. The method can be used for simultaneously simulating a plurality of sources, the transmission time of simulation photons in biological tissues is greatly saved, the absorption effect of fluorogen in the tissues to exciting light is considered, and photon transmission of the exciting light and that of fluorescent light in the biological tissues are respectively traced. The accuracy of the method is high, the light transmission information in real biological tissues can be obtained, the rich information provides a basis for the optimization of an optical imaging system, and accurate guide information is provided for optical diagnosis and optical treatment.

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

The invention provides an optical diagnosis device used for two-phase flow same-field testing. The optical diagnosis device comprises a high-speed laser device, a high-speed camera, a liquid jet generation device, a fluorescent light tracer particle generation device, a testing region unit and a sequential control device. The high-speed laser device serves as a light source for optical testing of liquid jet and flowing of fluorescent light tracer particles. A lens of the high-speed camera faces one face of the testing region unit. The testing region unit is a region for liquid jet and moving of the fluorescent light tracer particles, and the fluorescent light tracer particles can be evenly distributed in the testing region unit and effectively move along with environment gas in the testing region unit. According to the optical diagnosis device, liquid jet is marked through laser scattered light, environment gas motion is marked through fluorescent light signals of the fluorescent light tracker particles, and therefore two-phase flow separation and same-field testing can be achieved. The testing performance can be achieved just through one laser device and one camera, and therefore the optical diagnosis device is low in cost, simple and easy to use.

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

An engine spray flow field near-field region optical diagnosis system comprises a light splitting system, a multiplexing system, an optical Kerr gate strobing imaging system, and a comparison imaging system, which are disposed along the incident direction of femtosecond pulse laser. The light splitting system split the incident femtosecond pulse laser into three beams of light pulses which are different in wavelength and polarization characteristic and adjustable in time interval. The three beams of light pulses respectively record information of a spray flow field near-field region at different time points through the multiplexing system and then go through the optical Kerr gate strobing imaging system for imaging respectively. The optical Kerr gate strobing trajectory light imaging system can be used to effectively remove the influence of diffusion light and increase the imaging signal-to-noise ratio. The particle speed and acceleration information can be calculated through a single particle track in three flow field graphs recorded by the comparison imaging system.

A wafer is positioned on a wafer support apparatus beneath an electrode such that a plasma generation region exists between the wafer and the electrode. Radiofrequency power is supplied to the electrode to generate a plasma within the plasma generation region. Optical emissions are collected from the plasma using one or more optical emission collection devices, such as optical fibers, charge coupled device cameras, photodiodes, or the like. The collected optical emissions are analyzed to determine whether or not an optical signature of a plasma instability exists in the collected optical emissions. Upon determining that the optical signature of the plasma instability does exist in the collected optical emissions, at least one plasma generation parameter is adjusted to mitigate formation of the plasma instability.

The invention relates to the field of nuclear fusion and optical diagnosis and discloses a method for detecting instant temperature of a graphite tile of a partial filter of a magnetic confinement fusion device. The technical schemes includes that when the magnetic confinement fusion device works normally, terahertz waves are perpendicularly injected into the graphite tile from a position outside a window, and a probe is used for measuring and recording a terahertz time-domain spectrum Omega<T>(t) reflected by the graphite tile under working temperature. The time-domain spectrum is analyzed and processed and transformed in Fourier transformation in an effective frequency domain to obtain a frequency domain spectrum F<T>(omega) under the working temperature. At the moment, data automatically selects a characteristic spectral line, reads positions of the characteristic spectral line in a data base under calibrated temperature, frequency shift amount is obtained by comparing the two positions, a functional relationship of frequency shift amount - temperature of the data base is compared with the frequency shift amount, and the instant temperature is then calculated, outputted and led to a computer system to be stored. According to the method for detecting the instant temperature of the graphite tile of the partial filter of the magnetic confinement fusion device, technology of reflecting the terahertz time-domain spectrum is adopted, the thermal shock instant temperature of the graphite tile of the partial filter of the magnetic confinement fusion device can be detected online, synchronously, and without contact or damage.

Methods using internal image antibodies for photodiagnosis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors. The photoactive molecules are then activated for diagnosis or therapy. Advantageously, the internal image antibody is specific for a biological receptor, but does not require isolation of the receptor to prepare the antibody, and provides the desired specificity and selectivity for targeted diagnosis or therapy.

The present invention relates to a breast cancer diagnosis device. More particularly, the present invention relates to a breast cancer diagnosis device for early detection of the presence or absence of breast cancer lesions inside the breast of a diagnosis subject. The breast cancer diagnosis device includes: an X-ray diagnosis unit generating an X-ray image of a diagnosis subject; an optical diagnosis unit generating an optical transmission image of the diagnosis subject; and a transfer unit which is coupled to the X-ray diagnosis unit and the optical diagnosis unit to transfer all or part of the X-ray diagnosis unit and the optical diagnosis unit, and sequentially transfer all or part of the X-ray diagnosis unit or the optical diagnosis unit toward the diagnosis subject.

The invention discloses a common optical path intelligent optical diagnosis and treatment system based on optical coherence tomography. The system comprises: a laser and a frequency domain optical coherence tomography module, wherein the frequency domain optical coherence tomography module is configured to image a target area of a tissue sample to obtain an imaging result; a controller is used tocomplete image processing and display, scan a galvanometer to drive signal generation, and control the laser to emit laser light according to the imaging result; and a common optical path scanning module is configured to combine the imaging laser and the output laser of the laser into the optical path to illuminate the tissue sample to image the target area and ablate the portion to-be-ablated ofthe target area. The system combines scanning imaging and laser ablation in hardware, and realizes intelligent laser ablation guided by high-resolution structure images with a probe. Compared with a combining mode in the related art, the image quality is high, the end optical path structure is compact, and no image registering is required, the efficiency and accuracy of laser ablation can be increased, and the difficulty of manual operation is reduced.

The invention discloses a high-resolution and high-gain-multiple low-light image intensifier, relates to the field of low-light detection, and solves the problem that an existing image intensifier cannot give consideration to high resolution and high gain at the same time. The image intensifier mainly comprises a low-light input window, an input photocathode, a single-layer micro-channel plate, atleast one stage of high-resolution optical amplifier, an output photocathode, an output optical fiber bundle, a vacuum sealing cavity and a power supply module. Based on the single-layer micro-channel plate and the multi-stage amplification technology, the gain multiple of the double-layer MCP low-light-level image intensifier can be provided, the resolution of the single-layer MCP low-light-level image intensifier can be maintained, and high-gain-multiple and high-resolution detection of a large area array can be achieved at the same time. The image intensifier has important application value in the fields of plasma imaging, combustion and hydromechanics optical diagnosis, biological and medical images, astronomical observation, remote sensing and telemetering, criminal investigation, military investigation and the like.