54 results about "Optical diagnosis" patented technology

The invention discloses an aggregation-induced emission fluorescent compound with near infrared (NIR) luminescence. The fluorescent compound is wrapped by a polymer matrix to form a nano aggregate, which proves that the fluorescent compound shows excellent photothermal conversion efficiency while maintaining high fluorescence quantum yield. Therefore, compared with the mode of relying on high permeability and retention (EPR) effect, the nanometer aggregate accumulation guided by the photo-induced thermoacoustic effect (PTA) can further improve the photo-thermal treatment effect. In-vitro and in-vivo verification further confirms that the nano-aggregate shows excellent fluorescence-guided optical diagnosis and treatment capability in the aspect of tumor elimination.

The invention discloses a visible light bremsstrahlung diagnostic device and a fusion plasma electron density profile measurement method. The visible light bremsstrahlung diagnostic device comprises a vacuum chamber, an objective lens, an optical fiber, a spectrograph and a spectrum detector. The vacuum chamber is used for generating plasma and is provided with an observation window; the objective lens, the optical fiber, the spectrograph and the spectrum detector are sequentially connected to form an optical diagnosis system for observation, and correspondingly, the front end of the objective lens faces the observation window, and visible light bremsstrahlung radiation of the plasma is observed through the observation window. The fusion plasma electron density profile measurement method comprises the following steps: S100, measurement: measuring plasma radiation through the visible light bremsstrahlung radiation diagnosis device; and S200, calculation: calculating the electron density profile of the plasma through a formula. Compared with an existing contact type measurement method, the visible light bremsstrahlung radiation diagnosis device and the fusion plasma electron density profile measurement method are a non-contact and interference-free measurement method.

The invention belongs to the technical field of liquid engines, and discloses a liquid engine inner wall liquid film forming and visual diagnosis system which comprises a multifunctional spray pipe support and a calibration device, a liquid film forming device is arranged at the top of the multifunctional spray pipe support, and a visual spray pipe is arranged at the bottom of the liquid film forming device. According to the technical scheme, the liquid film forming device, the visual spray pipe and the multifunctional spray pipe support are arranged, when the liquid film forming device, the visual spray pipe and the multifunctional spray pipe support are used in a whole and matched mode, liquid film generation can be achieved, optical diagnosis can be conducted on the generated liquid film, and therefore a set of complete experimental research method is formed; an effective analysis means can be provided for a breaking mechanism of the liquid film in a high-temperature and high-speed airflow environment, the research blank is filled up, so that the understanding of breaking of the liquid film and generation of liquid drops is improved, and the initial flowing parameters of the liquid film can be accurately controlled and instability and experimental errors can be reduced through a method for forming the liquid film by impacting the wall surface through jet flow.

The invention relates to a method for identifying a meningioma infiltrating dura mater and delimiting an infiltrating position boundary based on a multi-photon technology, and belongs to the field of computer vision and biomedical optics. The method comprises the following steps: acquiring endogenous multi-photon optical signals of meningioma tissues and normal dura mater tissues around the meningioma tissues; in a multi-channel mode, high-resolution and high-contrast microstructure imaging of meningioma and normal dura mater tissues around the meningioma is obtained; the method comprises the following steps: acquiring certain quantitative morphological optical diagnosis parameters for identifying epidural tissue infiltration at the periphery of meningioma, and acquiring spectral images of tumors at the infiltration part and peripheral normal epidural tissues in a spectral mode; therefore, the infiltration of peripheral tissues of meningioma can be quantitatively and qualitatively identified in morphology and spectrum. And finally, determining the boundary of the tumor tissue at the infiltration position according to different texture analysis on the multiphoton microscopic images of the tumor tissue at the infiltration position and the surrounding tissue. The method disclosed by the invention is beneficial to quickly and automatically identifying the infiltrated boundary of the peripheral dura mater tissue.

The utility model discloses an arc extinguish chamber nozzle device for optical diagnosis of a gas circuit breaker, which comprises a nozzle body, a throat communicated with an air inlet and an air outlet at two opposite ends is formed in the nozzle body, and a hole body assembly for optical measurement of an arc is arranged on the side wall of the nozzle body. The hole body assembly comprises a schlieren measuring hole group and a soup-son scattering method measuring hole group; the schlieren measuring hole group comprises two strip-shaped holes which are symmetrically formed in the nozzle body along the radial direction of the throat; and the soup-son scattering method measuring hole group comprises two cylindrical holes which are symmetrically formed in the nozzle body along the radial direction of the throat. A nozzle body is provided with a hole body assembly and a soup-son scattering method measuring hole set, and two strip-shaped holes are symmetrically formed in the nozzle body in the radial direction of a throat; the two cylindrical holes are symmetrically formed in the nozzle body in the radial direction of the throat, the schlieren measurement method or the soup-son scattering method can be selected to measure the arc according to needs, and therefore the arc measurement universality of the arc extinguish chamber nozzle device provided by the utility model is improved.

The invention relates to the technical field of space irradiation environment simulation based on ultra-short and ultra-strong laser, and discloses a space irradiation environment simulation device and method based on ultra-short and ultra-strong laser. The device comprises a laser compression cavity, a laser focusing and optical diagnosis system, a primary target system, a secondary conversion target system, a beam sorter, an ion transport system, an electron transport system and a test target holder system. The multi-particle synchronous irradiation device has the beneficial effects that the interaction between the laser pulse and the target material is accurately controlled, so that high-energy ion beams, electron beams and other various particles can be generated, and multi-particle synchronous irradiation is successfully realized. The synchronous irradiation capability enables the experiment to simulate a complex irradiation environment in the space more truly, further reveals the interaction and synergistic effect among a plurality of particles, and overcomes the limitation that a traditional large accelerator can only simulate a single environment.

The invention provides an axial staged rotational flow combustion device, an airflow flow calculation method and an optical diagnosis method. The axial staged rotational flow combustion device comprises the axial staged rotational flow combustion device, a laser generating device and an optical image capturing device. The laser generating device comprises a laser generator and a laser attenuator; the axial staged rotational flow combustion device comprises a primary premixing cavity, a rotational flow premixing cavity, a staged optical combustion chamber and a tail gas discharger which are sequentially arranged from the gas inlet end to the gas exhaust end. The laser generator and the laser attenuator are arranged on the two sides of the grading optical combustion chamber respectively, and the connecting line of the laser generator and the laser attenuator is a light path of planar laser. The optical image capturer is arranged in the vertical direction of the light path and used for capturing spatial distribution information of excited free radicals in a flame field of the grading optical combustion chamber. The purposes that combustion flames are generated based on the axial staged rotational flow combustion device, and spatial distribution information of excited-state free radicals in a flame field is captured through the laser generation device and the optical image capture device are achieved.

The present application relates to the technical field of cancer detection, in particular to a kind of tumor imaging guided photodynamic therapy reagent.The reagent is named ADS254BE / H2TPP NPs, which is composed of hydrophobic conjugated polymer ADS254BE and tetraphenylporphyrin H2TPP doped polymer microspheres, and the surface of the polymer microspheres also has PSMA modification layer.The reagent is prepared by uniformly mixing ADS254BE, H2TPP and PSMA solution, ultrasonic treatment, room temperature standing, and then evaporating solvent in the solution.The photodynamic diagnosis and treatment reagent provided by the present application shows bright red emission centered at 650nm, relatively large stoke shift, higher singlet oxygen generation rate, and good light stability and biocompatibility.The present application provides a feasible strategy for constructing new optical diagnosis and treatment integrated reagent, and is expected to promote the development of imaging guided photodynamic therapy.

The invention discloses an A-D-A type NIR-II multi-mode optical diagnosis and treatment agent with multi-mode imaging guiding and photodynamic-photo-thermal synergistic treatment functions as well as a preparation method and application of the NIR-II multi-mode optical diagnosis and treatment agent. The NIR-II multi-mode optical diagnosis and treatment agent comprises a compound as shown in a structural formula I, or pharmaceutically acceptable salt, solvate and tautomer of the compound. According to the NIR-II multi-mode light diagnosis and treatment material, multi-mode imaging guidance and the photo-thermal-photodynamic effect are combined, many limitations in the prior art can be overcome, efficient diagnosis and treatment of diseases such as tumors and inflammation are achieved, and then development of the multi-mode diagnosis and treatment technology is promoted.

The present application relates to the technical field of high-voltage discharge plasma, and provides a high-voltage discharge plasma element detection device, which comprises an optical platform, a discharge reaction unit, an electrical diagnosis unit and an optical diagnosis unit; the discharge reaction unit, a fiber displacement stage and an ICCD displacement stage are installed on the optical platform; the discharge reaction unit comprises a sample carrier, a supporting component, a ground electrode and a high-voltage electrode; the sample carrier is arranged on the supporting component, and the center of the sample carrier is provided with a small hole; the ground electrode is installed at the root of the optical platform and is grounded, and the needle tip of the ground electrode faces the center of the sample carrier; the high-voltage electrode is arranged above the small hole of the sample carrier, and a plurality of groups of radiating fins are installed on the high-voltage electrode; the discharge reaction unit is connected in series with a parameter adjustment dark box, and the parameter adjustment dark box is connected with a high-voltage alternating current power supply; and the present application can realize accurate regulation and control of the discharge mode and detection of metal elements in solids.

The application discloses an experimental system for analyzing combustion of aluminum powder with different concentrations, and belongs to the field of aluminum powder combustion experiments.The application comprises a multi-element diffusion flat flame burner, an aerosol generator and an optical diagnosis system.The multi-element diffusion flat flame burner and the aerosol generator are placed in a high-pressure bin, and gas paths are connected.The high-pressure bin is closed, combustion gas is introduced from the lower part of the burner, oxidizing gas is introduced from the upper part of the burner, mixing is carried out in a capillary, and the capillary mouth is reached.The multi-element diffusion flat flame burner simulates the high-temperature gas phase environment and component atmosphere in a real combustion device through gas distribution, carries out particle ignition and combustion characteristic test through central supply of aerosol, and has good optical visualization conditions.The aerosol generator is used to generate relatively uniform monodisperse aluminum powder aerosol from a powder generator without using a vibration device.The optical diagnosis system obtains temperature information of combustion through various means, carries out comparison, and increases accuracy of experimental data.

The invention discloses a polymer photosensitizer, nanoparticles and a preparation method and application of the polymer photosensitizer and the nanoparticles, and belongs to the technical field of biological optical diagnosis and treatment. The polymer comprises SPI and FPI, and SPI nano particles and FPI nano particles are prepared from the polymer. Under the irradiation of low-power laser, the SPI nano particles and the FPI nano particles can generate I-type active oxygen, and have excellent near-infrared two-region fluorescence emission performance. The preparation of the near-infrared two-region fluorescence imaging guided low-power laser triggered photodynamic therapy reagent is realized, a new method is provided for developing a low-power efficient photosensitizer, and the near-infrared two-region fluorescence imaging guided low-power laser triggered photodynamic therapy reagent has a potential application prospect in the field of biomedicine.

The application discloses a method for identifying a soot formation critical point in a premixed stable stagnation flame. The method is verified by taking ethylene premixed stable stagnation flame as an example, and the soot formation critical point is identified by using the method. The method collects a large number of flame pictures under each equivalent ratio by a non-invasive optical diagnosis system, and the images are processed by using python. The method provides an error index for judging the influence degree of the number of pictures on the result, quantifies the soot formation process, gives the definition of the soot critical point, and provides an innovative identification index. It is verified by experiments that the method can accurately capture a series of changes of the soot formation region of the premixed stable stagnation flame, and then identify the soot formation critical point.

The invention relates to an electrical connector for transmitting an electrical power signal on an electrical power line (210), the electrical connector comprising an electrical contact configured to be connected to the electrical power line (210) and an optical contact (11) configured to be connected to an optical diagnosis line (103). The invention further relates to an electrical connection system (100) comprising an assembly of electrical connectors (1a, 1b). The invention also relates to an electrical connection network for an aircraft, the electrical connection network comprising the electrical connection system (100).

The invention discloses a flame propagation characteristic testing device which comprises a combustion chamber and a buffer chamber, the combustion chamber comprises a transparent enclosure wall and a first supporting part, the internal space of the transparent enclosure wall is used for forming a combustion cavity, the transparent enclosure wall is connected to the first supporting part, and the first supporting part is provided with a micro-channel; the micro-channel is communicated with the internal space of the transparent enclosure wall; the buffer chamber is provided with a nozzle facing the micro-channel, and the nozzle is used for conveying the combustion-supporting mixed gas to the micro-channel. The combustion chamber is defined by the transparent enclosure bulkhead in the combustion chamber, flames formed by the combustion phenomenon are located in the combustion chamber, a worker can conveniently observe through the transparent enclosure bulkhead, and a light path of an optical diagnosis system can conveniently penetrate through the combustion chamber; the nozzle conveys combustion-supporting mixed gas to the micro-channel, so that the flame propagation characteristic test device can be used for the quenching mechanism and influence factors of premixed flame in the micro-channel.

An optical diagnosis system for ignition of single-particle excavate waste includes: an excavate waste combustion device, an excavate waste feeding device, an oxidant supply device, a flow monitoring device, an observation device and a flue gas analysis device. The excavate waste feeding device cooperates with the excavate waste combustion device, the oxidant supply device is connected to the excavate waste combustion device via the flow monitoring device, the flue gas analysis device is connected to the excavate waste combustion device, and the observation device cooperates with the excavate waste combustion device. Excavate waste particles are automatically conveyed by a slide rail bracket, and particles are prevented from falling off due to thermal expansion by adopting a hoisting tray. A flow stabilizing plate is added at a bottom of the combustion device, and the captured image is processed to achieve high-precision judgment of the ignition moment.

The invention discloses a naphthalocyanine nano-liposome as well as preparation and optical diagnosis and treatment application thereof. The naphthalocyanine nano-liposome contains naphthalocyanine, dipalmitoyl phosphatidylcholine, molecular modified phospholipid polyethylene glycol with or without a cancer cell active targeting function, and cholesteryl hemisuccinate. The invention also discloses a preparation method of the naphthalocyanine nano-liposome, which comprises the step of preparing the liposome with or without the cancer cell active targeting function from the dipalmitoyl phosphatidylcholine, the molecule modified phospholipid polyethylene glycol with or without the cancer cell active targeting function and the cholesteryl hemisuccinate. And mixing the liposome with naphthalocyanine to obtain the naphthalocyanine nano-liposome. The naphthalocyanine nano-liposome can be applied to photoacoustic detection or imaging, photodynamic therapy, photothermal therapy and photodynamic and photothermal combined therapy of cancer cells or tumor tissues, and has remarkable application value.

The present invention discloses a multifunctional AIE optical diagnosis and treatment molecule and its azide compound, synthesis method and application. The multifunctional AIE optical diagnosis and treatment molecule uses triphenylamine as an electron donor and malononitrile fluorene as an electron acceptor. By adjusting the D-A structure of the molecule, a series of organic optical diagnosis and treatment molecules are synthesized, and a novel multifunctional optical diagnosis and treatment molecule with AIE properties is screened out. At the same time, further azide modification of the multifunctional optical diagnosis and treatment molecule can realize its covalent binding with functional groups such as polypeptides, DNA and small molecule compounds. The multifunctional AIE optical diagnosis and treatment molecule of the present invention has multifunctionality and can perform near-infrared fluorescence imaging, photodynamic therapy and photothermal therapy on tumors.

The application discloses a tar-containing biomass gasification gas MILD combustion system carbon smoke detection method, and relates to the technical field of renewable low-carbon energy utilization and carbon smoke emission control. The application comprises the following steps: S1, installing a tar-containing biomass gasification gas MILD combustion system; S2, installing a carbon smoke detection system; and S3, detecting a carbon smoke generation process. The application realizes fuel supply of the tar-containing biomass gasification gas through a controllable mixing evaporator, guarantees that the tar participates in combustion in a gaseous form, detects the whole carbon smoke generation process under the MILD combustion by combining a thermal migration sampling system and an optical diagnosis system, solves the fuel supply problem caused by the tar, realizes the MILD combustion of the tar-containing biomass gasification gas, and further provides an effective detection method for the whole carbon smoke generation process under the MILD combustion, and provides a solution for related experimental research.

The application provides an oil bubble discharge experiment platform comprising an optical diagnosis system, realizes quantitative research on bubble discharge characteristics of transformer oil under different parameters, and can observe clear images in a bubble discharge process, and the experiment platform comprises: a power supply system for power supply, wherein the power supply system comprises a test transformer, a protection resistor and a fast protection module; an experiment cavity for containing transformer oil; an electrode system installed in the experiment cavity and used for constructing a uniform electric field oil gap or a non-uniform electric field oil gap; a bubble generating system used for adding bubbles to the oil gap; a partial discharge detection system used for collecting partial discharge signals and analysis; and an optical diagnosis system used for observing the bubble discharge process of the oil gap in the experiment cavity; wherein the partial discharge detection system is further connected with the fast protection module, and is used for outputting signals to the fast protection module when a discharge or breakdown event occurs, so that the power supply system is cut off by the fast protection module.

The invention relates to a compound shown in a formula (I) and a compound shown in a formula (II), which can be used as a hemicyanine dye with integrated optical diagnosis and treatment performance, and application of the hemicyanine dye in tumor optical diagnosis and treatment, especially fluorescence and photoacoustic imaging.

A test system and method for the ignition characteristics of a repetitive frequency plasma jet for a propulsion system. The system includes a repetitive frequency pulsed plasma jet generation system using an energetic doped working medium, a test chamber, and diagnostic equipment. The repetitive frequency pulsed plasma jet generation system using an energetic doped working medium includes six modules: a capillary jet device, a pulsed voltage generation circuit, a pulse current generation circuit, a thyristor trigger circuit, an LC series resonant charging circuit, and a control system. The diagnostic equipment includes a high-voltage probe, a Rogowski coil, a collimating mirror, an optical fiber, a spectrometer, a high-speed camera, a pressure sensor, a thermocouple, an oscilloscope, and a data acquisition card. The system controls the pressure in the test chamber through a controllable valve to simulate the working pressure of the engine in the propulsion system, realizes electrical and optical diagnosis of the parameters of any plasma jet in the repetitive frequency discharge sequence through the introduction of a counter, and measures the temperature and pressure in the test chamber during the ignition process of the propellant in the engine under the action of the repetitive frequency jet. The electrical parameters of the capillary discharge and the temperature and pressure parameters of the propellant combustion are synchronized in time through the trigger electrode voltage signal, aiming to achieve multi-dimensional characterization of the ignition efficiency under the action of the repetitive frequency capillary discharge plasma jet.

The invention discloses a dicationic AIE photosensitive dye based on a non-conjugated N-methyl structure, and a synthesis method and application thereof. The photosensitive dye has a structure as shown in a general formula I. The invention further discloses a preparation method of the dicationic AIE photosensitive dye. According to the dicationic AIE photosensitive dye, aromatic compounds are connected in series with N methyl sites of indole and derivatives thereof, meanwhile, the aromatic compounds are coupled with AIE functional groups through a Knoevenagel condensation reaction, the quaternized dicationic characteristic can be achieved in one step, the excited state energy release process is effectively regulated and controlled, and aggregation-induced quenching is prevented. Meanwhile, the photosensitive dye has tunable absorption and emission spectrums, high photosensitization efficiency and high photo-thermal conversion efficiency in a near-infrared region. The nano-material has excellent tumor cell killing ability under near-infrared light irradiation, and has a good application prospect in the fields of biological imaging, preparation of biological optical diagnosis and treatment preparations and the like.

The application discloses an organic small-molecule optical diagnosis and treatment reagent, nanoparticles and a preparation method and application thereof. The organic small-molecule optical diagnosis and treatment reagent has high near-infrared second region fluorescence brightness, good photo-thermal conversion effect and can generate type I active oxygen. The nanoparticles have good water solubility and biocompatibility, excellent near-infrared second region fluorescence imaging capability, type I photodynamic and photo-thermal conversion performance. Under single near-infrared laser excitation, the nanoparticles can be used for preparing a type I photodynamic / photothermal combined treatment reagent under the guidance of near-infrared second region fluorescence imaging, and have good application prospect.

The invention discloses a high-pressure spray optical diagnosis experiment system using pulse excitation back pressure oscillation, and belongs to the field of atomization characteristic evaluation of oscillation spray of a liquid rocket engine. The system comprises a hyperbaric chamber system, a pulse excitation system and a test and optical diagnosis system. The hyperbaric cabin system comprises a cabin body and a quartz glass observation window. The cabin body is provided with a multi-path gas / liquid interface, a cable cabin penetrating interface, a pressure sensor interface and a pulse gun interface. Safety gas is introduced into the high-pressure cabin through the gas cylinder and the pressure reducing valve, and the specified back pressure is achieved in the cabin within the pressure bearing range so as to simulate different engine pressure environments. According to the invention, wide-frequency-domain and large-amplitude transient pressure oscillation is excited in a high back pressure environment, a pressure pulse disturbance scene under high pressure is simulated, a spraying experiment of an injector is carried out, and dynamic changes and influence rules of injection pressure drop, an atomization taper angle, liquid film breakage, a liquid film edge stability state, liquid film suction and separation and the like are analyzed; and engineering tests and product optimization of various types of inspirators are facilitated.

The invention discloses a method for measuring the transient temperature of a wall surface in a diesel oil impingement combustion process, which comprises an optical diagnosis experiment and simulation calculation, and aims to solve the problems of low response speed, single measurement range, interference on a temperature field and the like in the traditional contact type temperature measurement technology. And the defect that the temperature of the inner wall surface in the combustion duration is difficult to measure in an infrared temperature measurement technology is overcome. The implementation process comprises the following steps: building a constant-volume combustion experiment bench, and carrying out an optical diagnosis experiment of diesel impingement combustion characteristics by adopting a two-color method temperature measurement technology and an infrared temperature measurement technology; processing a two-color method temperature measurement image and an infrared temperature measurement image obtained by an experiment to obtain flame transient temperature data and wall surface transient temperature data under a non-combustion condition; building a diesel impingement combustion process simulation calculation model, and simultaneously calibrating the calculation model by using flame temperature data and wall surface temperature data under a non-combustion condition; and carrying out computational fluid mechanics simulation calculation based on the calibrated model to obtain the wall surface transient temperature under the combustion condition.

The invention discloses a femtosecond time resolution multi-exposure imaging system and a femtosecond time resolution multi-exposure imaging method for observing gas nucleus evolution near a material plate, and belongs to the technical field of ultrafast optical diagnosis. A single pulse emitted by a femtosecond laser light source is subjected to passive beam splitting through a transparent medium sheet queue, and a femtosecond multi-pulse probe cluster is generated; the formation of a gas nucleus is induced near a material interface through a gas nucleus inducing device, and the time sequence of the multi-pulse probe cluster, the formation of the gas nucleus and the exposure of the photosensitive element is accurately controlled by utilizing a synchronous control module; after analysis of the data processing and analysis module, femtosecond-level dynamic information of the whole process of gas nuclei near the material from primary generation, evolution to collapse can be obtained. The ultra-high time resolution is achieved through a simple and low-cost system, an effective means is provided for fine diagnosis of the ultra-fast transient process in the gas nucleus and material interaction, and the method has important application value in the fields of cavitation erosion mechanism research, high-performance material testing, hydraulic machinery and the like.

The present invention relates to the field of optical imaging. More particularly, it relates to fluorescent probes targeting carbonic anhydrase nine (CA-IX) comprising near-infrared (NIR) dyes of the cyanine. The invention also relates to the methods for preparing these compounds, to pharmaceutical compositions and kits incorporating them and to methods of use them as optical diagnostic agents in imaging or therapy of diseases such as solid tumors with hypoxic tissues involving cells expressing CA-IX. The compounds have formula (I).

The invention provides an optical diagnosis and treatment integrated system. The optical diagnosis and treatment integrated system comprises an optical imaging module, a laser ablation module and a light path control module, the optical imaging module is used for emitting first light and forming an image of target tissue at least according to the first light; the laser ablation module is used for emitting second light to ablate the target tissue; the light path control module is at least used for receiving the first light and the second light and transmitting the first light and the second light to the target tissue; wherein the light path control module comprises a rotor unit; the rotor unit is used for at least driving the first light to rotate around a preset axis. Various optical modules can be combined for use and do not interfere with one another.

This invention relates to the field of optical imaging. More specifically, it relates to fluorescent probes capable of effectively targeting prostate-specific membrane antigen (PSMA) and comprising heptamethrin dye having near-infrared (NIR) emission. The invention also relates to methods for preparing these compounds, pharmaceutical compositions and kits for introducing these compounds, and methods for using them as optical diagnostic agents in the imaging or treatment of diseases, particularly prostate cancer.