The invention relates to an upward horizontal layered filling mining method for a gently inclined-inclined thick ore body, which belongs to the field of underground mining methods, and comprises the following steps of: arranging a plurality of sections and a plurality of panels in
one stage, arranging a plurality of chambers in the panels, and arranging a plurality of ore beds in each chamber; at the stage, a stage
haulage roadway, a segmented stage connection roadway and a segmented
haulage roadway are formed in the strike direction of the ore body, and a slope ramp is excavated upwards from the segmented stage connection roadway; the stage
haulage roadway is communicated with the draw shaft connection roadway through a draw shaft; tunneling a stope connection roadway, a layered transportation roadway, a
cutting roadway, a room air return roadway, a ventilation connection roadway and a
pedestrian ventilation filling courtyard in a layered
stoping mode from bottom to top to form a stage air return connection roadway of the previous stage; and stopping and filling the whole chamber. The technical problems that the mining preparation
workload is large, mining safety and economical efficiency are difficult to consider, and the mining cost is high in a traditional mining method are solved.