242731 results about "Biomedical engineering" patented technology

A physiological patient monitor can include a front end conditioner that can receive analog sensor signal from a sensor responsive to a person's physiology. The patient monitor can further include an analog-to-digital converter that can convert analog sensor signal to a digital sensor information. The patient monitor can determine one or more patient specific physiological parameters. The patient monitor can further determine a physiological condition of a patient based on processing multiple physiological parameters. The patient monitor can generate a user interface that can included a visual representation of the patient's physiological condition.

A system for generating and detecting transient vapor nanobubbles in a fluid from a patient can include a micro-fluidic device to receive a flow of the fluid from the patient, a laser pulse source to provide a laser pulse to the flow of the fluid from a first side of the micro-fluidic device, a probe light source to provide a probe light to the flow from the first side of the micro-fluidic device, and a photodetector located at a second side of the micro-fluidic device opposite the first side. The photodetector can detect scattered, reflected, and / or deflected probe light and output a nanobubble signal including characteristics of optical scattering, reflecting, and / or deflecting by the transient vapor nanobubble.

The invention discloses a thrombus excision system. An embolus is extracted through a mechanical embolus extraction device, a blood vessel is dredged, and revascularization of the blood vessel is achieved. A saccule guide catheter is put at the near end of the embolus part when the embolus is extracted, blood flow is temporarily blocked, and thus a fine crushed embolus generated in the embolus extraction process is prevented from being flushed to the far end of the blood vessel; meanwhile, for a relatively large embolus, a part of thrombus can also be sucked by virtue of the saccule guide catheter, and then the residual thrombus can be extracted by virtue of a thrombus exsector. The thrombus exsector, the saccule guide catheter and a delivery microcatheter are arranged on the thrombus excision system disclosed by the invention, wherein the thrombus exsector is used as a main component, an excision spring is arranged, and the release state of the excision spring is a conical spiral state. Compared with the prior art, the thrombus excision system has the advantages that the thrombus exsector is very soft, the minimal through size is 0.014' (0.36mm), the thrombus exsector can easily enter a cerebral vessel, a near-end protection technology is adopted in the operation process, and thrombus suction is combined with mechanical embolus extraction, so that the success rate of the operation is improved, and the complications are reduced.

The present invention relates to the technical field of heart rate monitoring, discloses a heart rate monitoring method, wherein the heart rate monitoring method comprises: obtaining initial electrocardio signals of a user by a preset heart rate sensor, and acquiring initial acceleration energies of the user by a preset acceleration sensor; pre-treating the initial electrocardio signals, obtaining pretreated target electrocardio signals, and pre-treating the initial acceleration energies to obtain pretreated target acceleration energies, the present invention can be used to help doctors and users to know current heart rate conditions, make personalized and well-targeted health management measures and improve living quality.

In an example, a urine collection device includes a covering defining a recessed receptacle and a fluid collection assembly positioned in the recessed receptacle. The fluid collection assembly includes (i) a foam sleeve including a bore, (ii) a shape retaining element positioned in the bore of the foam sleeve and defining a passage, and (iii) a tube extending through the passage defined by the shape retaining element. The shape retaining element can conform the fluid collection assembly to a curved configuration and maintain the curved configuration of the fluid collection assembly until the curved configuration is adjusted. The urine collection further includes a top sheet coupled to the covering. The top sheet and the covering define an internal chamber of the urine collection device. The top sheet is configured to draw urine into the internal chamber and toward the fluid collection assembly.

A delivery device for delivering an instrument through an intravenous catheter may include a housing, a rotary element disposed within the housing, and an instrument. In some embodiments, the rotary element may include a groove, which may extend around at least a portion of the circumference of the rotary element. In some embodiments, the instrument may be disposed within the groove and / or between the rotary element and the housing. In some embodiments, in response to rotation of the rotary element with respect to the housing, the instrument may be advanced distally through an outlet of the housing. In some embodiments, the instrument may include a guidewire, a probe, blood draw tubing, or a light tube.

The present invention relates to the technical field of stomatology. Provided is an auxiliary dental implant generation method based on a diffusion model. The method in the present invention comprises: acquiring oral CBCT image data of historical patients, preprocessing the oral CBCT image data of the historical patients to obtain a CBCT image dataset, using the CBCT image dataset to train a multi-task segmentation network, and using the segmentation network to obtain an intraoral tissue segmentation result; using the intraoral tissue segmentation result to train detection networks from the three dimensions of a cross-sectional plane, a coronal plane and a sagittal plane, respectively; using the detection networks to obtain detection results in the three directions of the cross-sectional plane, the coronal plane and the sagittal plane; fusing the detection results in the three directions of the cross-sectional plane, the coronal plane and the sagittal plane, and using a majority voting algorithm to construct a three-dimensional bounding box, so as to acquire an edentulous area; and using the intraoral segmentation result and the edentulous area as prompt information to guide, by means of an iterative process, a network to generate a post-implantation effect. The implantation effect obtained by the present invention is highly accurate, thereby providing a more precise auxiliary tool for stomatology.

An example fluid collection assembly includes a sheath including a chamber and a fluid permeable body disposed in the chamber. The sheath includes a fluid impermeable barrier including a proximal region, a distal region, a first panel, a second panel attached to the first panel and defining an opening in the proximal region of the fluid impermeable barrier, and a fluid outlet at the distal region. The fluid permeable body includes a fluid permeable support and a fluid permeable membrane. The fluid permeable membrane includes a wicking material and is positioned such that the fluid permeable membrane is disposed to contact the penis in the chamber when the penis extends through the opening.

A urine collection device includes a collection member extending from a proximal end to a distal end. The proximal end includes an opening that provides access to an internal cavity of the collection member. The internal cavity includes a first chamber in fluid communication with a second chamber. The urine collection device includes a spacer in the second chamber, a first attachment member extending from a bottom wall of the collection member at the proximal end., a second attachment member extending from a top wall of the collection member at the proximal end, and an outlet for egressing urine from the internal cavity of the collection member. The first attachment member defines an aperture. The collection member is suitable to (i) direct urine from the first chamber to the second chamber and (ii) direct the urine in the second chamber distally toward the outlet.

A urine diversion device includes a diversion member extending from a proximal end to a distal end. The diversion member includes an opening that is configured to provide access to an internal cavity of the diversion member. The urine diversion device also includes a spacer in the internal cavity. The spacer includes one or more preferential separation regions in at least one of a first major surface or a second major surface. The urine diversion device also includes one or more attachment members configured to couple the diversion member to a user, and an outlet for egressing urine from the internal cavity of the diversion member. The diversion member is suitable to direct urine toward the outlet.

A system for monitoring hemodynamic status of a patient can include a transducer, an adapter and one or more monitor devices. The adapter may be in communication with the transducer and the one or more monitor devices. The adapter can be configured to receive and process data from the transducer such as unprocessed physiological data. The adapter can be configured to transmit data to the monitor device(s) such as processed and / or unprocessed physiological data. The adapter can be configured to generate, and transmit to the monitor devices(s), user interface data for rendering interactive graphical user interfaces to display information such as physiological information relating to a hemodynamic status of the patient. The adapter can be configured to receive and process, from the monitor device(s) user commands or instructions to control an operation of the system or its components.

An electrocardiogram device configured to transmit at least one signal responsive to a wearer's cardiac electrical activity can include a disposable portion and a reusable portion configured to mechanically and electrically mate with each other. The disposable portion can include a base having at least one mechanical connector portion, a plurality of cables and corresponding external ECG electrodes, and a first plurality of electrical connectors associated with the plurality of cables. The reusable portion can include a cover having at least one mechanical connector portion, a second plurality of electrical connectors configured to electrically connect with the first plurality of electrical connectors of the disposable portion, and an output connector port configured to transmit at least one signal responsive to one or more signals outputted by the external ECG electrodes of the disposable portion.

The AI-enhanced cellular modeling and simulation platform is a computational system designed to enhance biomedical research and development and personalized medicine and wellness. This platform integrates simulation modeling, machine learning and artificial intelligence, multi-omics data, and sophisticated data fusion and decision-support techniques to create comprehensive models of cellular systems and processes across multiple scales. It enables researchers and clinicians to simulate complex biological interactions, predict disease progression, and design or optimize treatment strategies or medical devices with improved accuracy and efficacy. The system's architecture allows for integration of various components, including real-time data processing, federated learning, and quantum computing enhancements. From personalized drug discovery and cancer therapies to synthetic biology and epidemiological analysis, this platform offers powerful tools for understanding and manipulating cellular systems and bioengineered systems. By bridging the gap between molecular-level interactions between cells and materials and organism-wide effects, it enables significant advancements in healthcare and biological sciences.

Systems, methods, and instrumentalities are disclosed for displaying a magnitude and location of a resulting tissue tension from an applied force to an instrument and a resulting tissue reaction. A surgical stapling device for monitoring and adapting to tissue tension during a surgical stapling procedure may measure strain on at least one component of the surgical stapling device resultant from one or more of an opposed force applied by a user and a force resisted by tissue associated with the tissue tension. The device may determine a location of the tissue tension based on historical surgical data, the opposed force, and the resisted force. The device may highlight the location of the tissue tension to aid in real-time surgical decision-making.

A method and system are disclosed for puncturing tissue, comprising a puncture device for puncturing tissue and a supporting member for supporting the puncture device. The puncture device is capable of being insertable within the supporting member and being selectively usable in co-operation therewith during a portion of a procedure for puncturing tissue and wherein the puncture device is usable independently therefrom during another portion of the procedure.

A wearable pouch operable to hold at least one portable battery pack and other power or communications equipment. The wearable pouch includes a main body with a front side, a back side opposite the front side, at least one sealable opening, and at least one opening for at least one lead from the at least one portable battery pack secured within the wearable pouch.

A blood pressure monitoring system, comprising: an exciter configured to produce an acoustic signal, the exciter being provided on a first substrate portion; a detector spaced apart from the exciter, the detector being configured to detect the acoustic signal and to produce an electrical output signal, the detector being provided on a second substrate portion that is mechanically or acoustically decoupled from the first substrate portion, wherein the detector comprises at least four detectors; and a processor configured to determine a blood pressure measurement from the electrical output signal.

The present disclosure relates to a method for detecting a state of wear of a cardiac support system. The method comprises a read-in step and a determination step. During the read-in step, a sensor signal representing an operating state of the cardiac support system is read in. During the determination step, a wear signal is determined using the sensor signal and a comparison rule. The wear signal represents the wear condition.

Systems, methods, and non-transitory computer readable media including instructions for interpreting facial skin micromovements are disclosed. An example head mountable system includes a housing configured to be worn on a head of a wearer. The head mountable system also includes at least one detector integrated with the housing and configured to receive light reflections from a facial region of the head and to output associated reflection signals. The head mountable system also includes at least one microphone associated with the housing and configured to capture sounds produced by the wearer and to output associated audio signals. The head mountable system also includes and at least one processor in the housing, configured to use both the reflection signals and the audio signals to generate output that corresponds with words articulated by the wearer.

A wearable pouch operable to hold at least one portable battery pack and other power or communications equipment. The wearable pouch includes a main body with a front side, a back side opposite the front side, at least one sealable opening, and at least one opening for at least one lead from the at least one portable battery pack secured within the wearable pouch.

A robotic medical system for performing a vascular procedure includes a procedure rail having a drive surface oriented along a generally vertical plane, a rail adjustment system configured to couple to a patient support table and having one or more movable arm segments, a fluidics system, and a plurality of catheter hubs operatively coupled to the procedure rail and configured to be axially translated along the drive surface along a longitudinal axis of the procedure rail. At least one of the plurality of catheter hubs is in fluid communication with the fluidics system, the at least one of the plurality of catheter hubs having a hemostasis valve and a catheter in communication with the hemostasis valve.

An electrosurgical instrument comprising an end effector is disclosed. The end effector comprises a first jaw and a second jaw. The first jaw comprises a first electrode. The end effector is movable from an open configuration to a closed configuration to grasp tissue. The second jaw comprises a second electrode configured to deliver a first monopolar energy to the tissue, a third electrode, and a conductive circuit selectively transitionable between a connected configuration with the third electrode and a disconnected configuration with the third electrode. In the connected configuration, the third electrode is configured to cooperate with the first electrode to deliver bipolar energy to the tissue. The conductive circuit defines a return path for the bipolar energy. In the disconnected configuration, the first electrode is configured to deliver a second monopolar energy to the tissue.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes an antimicrobial treatment mechanism to inactivate microbes flushed from the biological sample by preservation fluid flowed therethrough. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature while simultaneously treating microbial infections to prevent transmission between a donor and a recipient.

Systems and methods herein generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. The systems and methods herein can include an electronic pump that pumps gas into an organ and a mechanical pressure regulator to release gas based on organ pressure.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes support systems to permit arrangement of cooling media around a biological sample without potentially damaging direct contact between the cooling media and the biological sample. Systems and methods disclosed herein also include specific configurations, types, and performance characteristics of cooling media such as phase change materials to allow for extended hypothermic storage and transport.

The invention discloses a multifunctional magnetic stimulation treatment system and an application method thereof, relates to the technical field of medical equipment, and solves the defects of unstable curative effect and limited application range caused by individual difference in the existing system. The precision of the laser beam is automatically adjusted through a self-adaptive calibration algorithm, and it is ensured that a treatment area is accurately positioned; optimal stimulation parameters are calculated through a self-adaptive magnetic field depth optimization algorithm, and pertinence and effectiveness of treatment parameters are ensured; the treatment effect is predicted through a feedback mapping algorithm, and the treatment parameters are dynamically adjusted to ensure the safety and effectiveness of the treatment process; physiological data, symptom description and medical history information of a patient are comprehensively analyzed and recognized through the complex disease pattern recognition module, a detailed disease pattern recognition report is output, the application range of the system is expanded, and personalized disease prediction and risk assessment are provided; the applicability and the curative effect of an existing system are greatly improved.

The invention discloses a general KRAS inhibitor, the structure of which is shown as a formula I. In the formula, the definition of each substituent group is shown in the description and claims. The general KRAS inhibitor has the advantages of easily available raw materials, simple synthesis, wide action range and strong effect, and can reduce or avoid the possibility of drug resistance generation. # imgabs0 #

The invention relates to the field of medicinal chemistry, relates to a general KRAS inhibitor and medical application thereof, and particularly relates to a compound targeting KRAS and mutants KRASG12C and KRASG12D thereof and medical application of the compound. The pharmacological test result of the affinity of KRAS and mutants thereof shows that the affinity of the compound to a KRAS wild type and a KRASG12C mutant type thereof and a KRASG12D mutant type thereof is superior to that of a lead compound, and the compound has a potential inhibition effect on target spots of the KRAS wild type and the KRASG12C mutant type thereof and the KRASG12D mutant type thereof.

A computer-implemented method for designing a patient-specific orthopedic implant can include creating a user account associated with a patient. A patient-specific orthopedic implant can be designed based on patient data and imaging data. A healthcare provider can provide feedback for a design of the patient-specific orthopedic implant, treatment protocol, or other aspects of treatment. The patient can provide data and feedback.