21 results about "Gastric Tissue" patented technology

The invention belongs to the technical field of biological medicines, and relates to application of mannatide in preparation of a medicine for treating alcoholic gastric ulcer. The mannatide disclosed by the invention can be used for remarkably relieving gastric tissue hemorrhagic lesion and ulcer conditions of alcoholic gastric ulcer for the first time, and the mechanism comprises the following steps: reducing active oxygen generated by alcohol toxicity, and improving oxidative stress of a body by improving antioxidant enzyme activity of the gastric tissue; the inflammatory response of the organism is regulated by regulating and controlling an Akt / NF-kB pathway; a Bax-related apoptosis pathway is inhibited to protect gastric mucosa cells from alcohol-induced apoptosis, so that the integrity of gastric tissue mucosa is protected; the intestinal flora disorder caused by alcohol intake is regulated and controlled, and the acute alcoholic gastric ulcer is prevented by improving the intestinal flora composition of the alcoholic gastric ulcer. The application range of the mannatide is widened, and more solutions are provided for prevention or treatment of acute alcoholic gastric ulcer.

The invention relates to an image segmentation network method based on dual-path cross-latitude attention, and belongs to the technical field of medical image processing and deep learning. The method comprises the following steps: an input layer performs size adjustment and standardization processing on a stomach tissue pathological image; the encoder adopts a dual-path down-sampling architecture, combines a dual-path feature interaction mechanism, extracts multi-scale features through depth separable convolution and fuses the multi-scale features; the shallow jump connection layer extracts features based on a cross-latitude feature fusion mechanism by dividing cross dimension and standard space dimension branches and fuses the features to generate jump connection features; the decoder adopts an up-sampling architecture and is combined with a composite pooling attention enhancement mechanism to extract local features and generate decoding features; and the output layer outputs a lesion region segmentation result through single-channel convolution and an activation function. The accuracy and stability of lesion area segmentation of the stomach tissue pathological image are effectively improved, and reliable image analysis support is provided for clinical pathological diagnosis.

An implantable device for the treatment of acid reflux disease has a body including an outer surface adapted to rest against a patient's fundus wall. The device, when implanted in the patient, fills a volume in the patient's abdomen in the cardia area and above the cardia of the patient, when standing. The body prevents the cardia from moving through the diaphragm opening into the thorax, thereby preventing reflux by keeping the abdominal pressure supporting the cardia sphincter muscle. The device may be affixed to stomach tissue. The device may also be invaginated or otherwise indirectly secured in position.

The present application relates to the technical field of medicine, in particular to a kind of drug composition for improving acute alcoholic gastric mucosal injury and application.The present application discloses the new medical use of ganoherbae decoction for the first time, and the composition can increase the activity of key enzyme in the stomach and liver tissue of acute alcoholic gastric mucosal injury mice, reduce the content of pro-inflammatory factor TNF-α in gastric tissue, increase the production of anti-inflammatory factor IL-10 in gastric tissue, reduce the inflammatory damage of ethanol to gastric mucosa, increase the level of protective factor EGF, SS and PGE-2 in serum, enhance the defense mechanism of gastric mucosa, and improve the repair ability of gastric mucosa.The discovery will have a significant impact on the research and treatment of acute alcoholic gastric mucosal injury disease, and has clinical practical value.

The composition provided by the invention takes bear gall wood as a monarch drug and takes earthworm, bletilla striata, bighead atractylodes rhizome, Chinese yam and white paeony root as ministerial drugs, the earthworm and bletilla striata jointly play the effects of promoting blood circulation to remove meridian obstruction, dispersing blood stasis, removing stasis, astringing to stop bleeding and repairing injury, and the bighead atractylodes rhizome and Chinese yam are used as ministerial drugs and are used for strengthening spleen and stomach, replenishing qi and blood, providing fundamental power for the whole prescription and supporting healthy qi; liver softening, spasm relieving and pain relieving can be achieved; meanwhile, the traditional Chinese medicine composition has the effects of nourishing blood and astringing yin, can prevent other medicines in the formula from being too warm and dry or consuming yin blood, and forms dynamic and static combination compatibility with the minister medicine earthworm for promoting blood circulation to remove meridian obstruction; hairyvein agrimony, herba violae, vernonia graveolens, cuttlebone, mangnolia officinalis, semen raphani and endothelium corneum gigeriae A large number of pathological experiments prove that the traditional Chinese medicine composition can reduce stomach tissue inflammation, oxidative stress and activate apoptosis signal channels by acting on MAPK, PI3K-Akt and HIF-1 signals, so that the effect of treating chronic atrophic gastritis is achieved.

The invention relates to hybrid nano-clay and a preparation method and application thereof, the hybrid nano-clay comprises hybrid nano-clay particles with adhesive power, the hybrid nano-clay particles comprise nano-clay with the surface modified with a metal polyphenol network, and the metal polyphenol network is formed by self-assembly of Zn < 2 + > and tannic acid; the mass percent of the metal polyphenol network in the hybridized nano-clay particles is not less than 33%. The hybridized nano-clay particles provided by the invention have the capabilities of resisting oxidation, resisting bacteria and stopping bleeding; the gel can be adhered to stomach tissues, and free radicals in the body can be efficiently removed; the secretion of gastric mucosa protection factors can be stimulated, the complete form of the gastric mucosa is maintained, the damaged gastric mucosa is comprehensively protected and repaired, and the stomach health level is remarkably improved.

An implantable device for the treatment of acid reflux disease has a body including an outer surface adapted to rest against a patient's fundus wall. The device, when implanted in a patient, fills a volume in the patient's abdomen in the cardia area and above the cardia of the patient, when standing. The body prevents the cardia from moving through the diaphragm opening into the thorax, thereby preventing reflux by keeping the abdominal pressure supporting the cardia sphincter muscle. The device may be affixed to stomach tissue. The device may also be invaginated or otherwise indirectly secured in position.

The invention discloses a manufacturing method of a magnetic response millimeter-scale adhesion mobile robot for intragastric targeted drug delivery and pathological detection and the adhesion mobile robot. The method comprises the following steps: manufacturing a magnetic sheet with a simple harmonic magnetization curve; manufacturing a flexible frame, wherein a plurality of mounting holes for accommodating magnetic sheets are formed in the flexible frame; each magnetic sheet with a simple harmonic magnetization curve is mounted to a flexible frame, thereby forming a magnetic response millimeter-scale adhesion mobile robot for intragastric targeted drug delivery and pathological detection. According to the adhesion mobile robot manufactured through the method, the thin liquid film is transmitted on the wet and slippery surface through wave type movement of the magnetic response sheet-shaped soft material, so that crawling propelling is achieved by means of counter-acting force generated by the liquid film, the robot can stably crawl on the wet and low-friction stomach tissue surface by means of the adhesion moving characteristic, and the robot has a good application prospect. Good environmental adaptability is shown.

The invention relates to the field of fungal polysaccharide application, and discloses a preparation method and application of morchella polysaccharide. The preparation method comprises the following steps: step 1) leaching dry morchella esculenta powder with water to obtain a leaching solution; carrying out alcohol precipitation on the leach liquor to obtain a precipitate; 2) adding water into the precipitate for redissolving, removing protein, and then dialyzing and freeze-drying to obtain a morchella esculenta crude polysaccharide extract; 3, the morchella esculenta crude polysaccharide extract is dissolved in water and purified through adsorption chromatography, and the morchella esculenta polysaccharide is obtained.The morchella esculenta polysaccharide has the protection effect on alcoholic stomach injury in vivo and in vitro, stomach tissue inflammatory response is adjusted by adjusting an NF-kb channel, and reference value is provided for development application of the morchella esculenta polysaccharide.

Stomach tissue is manipulated and fastened with a tissue grasper and a tissue shaper to form folds in the stomach. The tissue grasper and the tissue shaper rotate and translate relative to one another. The tissue grasper has a plurality of vacuum orifices to adhere the tissue grasper to tissue.

The present invention provides a hyperthermia-induced gut microbiome- mediated modulation of the host immune system for the treatment of gastric / gastric MALT / Duodenum cancer; the said system uses a wild type / non-pathogenic / attenuated strain coated with iron oxide nanoparticles to specifically target the cancerous tissue by applying an external field around the gastric tissue the said iron oxide generates heat on bacteria surface and causes lysis of bacteria in the tumor microenvironment; the lysis of bacteria triggers various potent immune activator and cytokines to activate antigen-presenting cells including lymphocytes and macrophages; the said antigen presenting cell further, eliminates cancer cell from the gut microenvironment and eventually clean tumor microenvironment. Additionally, the activated lymphocytes will be antigenic memory against bacterial particles and cancer tissues. Furthermore, the said treatment system does not involve the use of any chemotherapeutic drug or radiation treatment and, thus, precludes undesirable side effects of chemotherapy as well as minimizes toxicity.

A method of endoscopically reconstructing a stomach includes passing an end effector of an intraluminal treatment device through an esophagus and into a stomach; directing the end effector to a position adjacent a fold extending from a lesser curvature of the stomach; grasping the fold between a first jaw and a second jaw of the end effector; deploying fixation elements from the end effector and into the fold; and cutting through the fold adjacent to the fixation elements so as to form a passageway through the fold.

The utility model relates to medical supplies technical field, especially a kind of gastrointestinal postoperative nursing device, including abdominal belt, the front end middle part of abdominal belt is fixedly connected with nursing assembly, the left part and the right part of front end of abdominal belt are fixedly connected with connecting band, the front end of two connecting bands is fixedly connected with several silica gel balls, the left end of abdominal belt is fixedly connected with first fixed band, the right end of abdominal belt is fixedly connected with second fixed band, the outside of first fixed band and second fixed band is fixedly connected with elastic component, the outside of two elastic components is fixedly connected with fixed component with together.The utility model relates to a kind of gastrointestinal postoperative nursing device, the inflatable nursing pad in nursing assembly can be inflated according to patient's demand adjustment, the nursing pad after proper inflation can form accurate local compression to surgical site, play the effect of hemostasis, alleviate swelling, while providing buffer protection for fragile postoperative gastrointestinal tissue, avoid direct impact of external force.

The invention discloses a preparation method and application of multifunctional hydrogel for gastric ulcer mucosa repair, and is characterized in that 4-PEG-S is prepared, epsilon-polylysine and 4-PEG-S are respectively dissolved in a phosphate buffer solution with the pH value of 7.4 to respectively obtain an epsilon-polylysine solution and a 4-PEG-S solution, and the epsilon-polylysine solution and the 4-PEG-S solution are dissolved in a phosphate buffer solution with the pH value of 7.4 to obtain a hydrogel solution; then mixing an epsilon-polylysine solution and a 4-PEG-S solution in an isometric manner to obtain a mixed solution, then adding plasmid defensin beta1 wrapped by a cell transfection reagent, and mixing to prepare hydrogel; the preparation method has the advantages that the prepared multifunctional hydrogel carries the DEF beta 1 gene, not only is the excellent physical and chemical properties of an SETF matrix completely reserved, but also the hydrogel is endowed with biological activity of targeted regulation of gastric mucosa immune microenvironment and enhancement of epithelial barrier function by efficiently delivering the DEF beta 1 gene, self-healing and repair of stomach tissues can be induced, and the hydrogel has a good application prospect. The strategy upgrade from passive protection to active repair is realized, the curative effect is remarkable, and the side effect is small.

The present application belongs to the technical field of biomarkers, and particularly relates to a system for evaluating the effectiveness of exercise intervention and application thereof. The present application finds through experiments that the Lac-Phe level in the stomach of obese patients is significantly reduced after exercise intervention, and other tissues have no significant change. Considering the role of the stomach in endocrine signal transduction, especially through ghrelin and other appetite-related hormones, this indicates that there is a potential interaction between Lac-Phe and the stomach pathway in regulating post-exercise satiety. Therefore, the expression level of Lac-Phe in the stomach tissue can be used as an effective index for evaluating the weight loss effect of exercise on obese patients.

The application discloses a kind of fungi microbial community as the application of gastric cancer diagnosis marker, the fungi microbial community is selected from one or more in fungi door level, genus level and species level.By the ITS sequencing of fungal DNA and the taxonomic annotation of reading of GC tissue, cancer adjacent tissue and healthy (HC) gastric tissue, a total of 4.5 million valid tags are generated, divided into 1631 classification units (OTUs), and 10 door levels and 301 genus levels of fungal subgroups are identified.The proportion of Basidiomycota and Ascomycota in GC group increases, and the high expression of Cystobasidium, Cutaneotrichosporon, Apodus, Apiotrichum, Simplicillium, Lecanactis, Rhizopus, Rhodotorula, Exophiala and Sarocladium in GC can be used as the fungal microbial community marker for gastric cancer diagnosis, and is closely related to the occurrence and development of gastric cancer.

An implantable device for the treatment of acid reflux disorder has a body that includes an outer surface adapted to rest against the patient's abdominal wall. When implanted, the device fills a volume in the patient's abdomen in the area of ​​the cardia and above the cardia when the patient is standing. The body prevents the cardia from moving through the diaphragmatic opening into the thorax, thereby preventing reflux by maintaining abdominal pressure and supporting the cardiac sphincter muscle. The device may be fixed to the stomach tissue. It may also be invaginated or otherwise indirectly secured in position.

The invention relates to a preparation method and application of a gastric cancer organoid culture medium. The culture medium for the gastric cancer organoid comprises a basic culture medium, a complete culture medium, a cell factor supply system, swine-derived hydrogel, beneficial bacterium metabolites and plant extracts, the basic culture medium is a DMEM / F12 basic culture medium; the complete culture medium is a DMEM / F12 complete culture medium; the cell factor supply system consists of fibroblasts, vascular endothelial cells and mesenchymal stem cells; the pig source hydrogel is prepared from pig small intestine tissues or pig stomach tissues; the beneficial bacterium metabolite is prepared from butyrate, indole-3-propionic acid, reuterin and cobalamin; the plant extract is prepared from tea polyphenol, baicalin, ginsenoside Rg3, curcumin and resveratrol. The culture medium for the gastric cancer organoid breaks through the bottlenecks of high cost, low stability and weak function of traditional organoid culture, and provides a model system capable of being popularized on a large scale for precise medical treatment of gastric cancer.

This invention discloses the application of Amomum villosum extract in the preparation of drugs for the prevention and treatment of functional dyspepsia, belonging to the field of biotechnology. The extract, when applied to the prevention and / or treatment of functional dyspepsia, can increase plasma levels of motilin (MTL) and gastrin (GAS), promote gastrointestinal motility, significantly improve gastric emptying rate in functional dyspepsia model mice, improve pathological damage to gastric tissue, restore mitochondrial function in gastric tissue, and regulate the expression of related factors in gastric tissue. Even at low doses, it can effectively increase plasma MTL and GAS levels in loperamide hydrochloride-induced functional dyspepsia model mice, improve gastric emptying rate, effectively improve pathological damage to gastric tissue in these mice, and regulate the expression of related factors in the gastric tissue. The raw materials of this invention are derived from natural products, are easy to collect, and have high safety.

A kind of hybrid nanoclay and its preparation method and application, including hybrid nanoclay particles with adhesion, the hybrid nanoclay particles include nanoclay with metal polyphenol network on surface, the metal polyphenol network is formed by Zn 2+ And tannic acid self-assembly;The mass percentage of metal polyphenol network in hybrid nanoclay particles is not less than 33%. The hybrid nanoclay particles provided by the present application have antioxidant, antibacterial and hemostatic capacity;Can adhere to stomach tissue, can efficiently remove free radicals in vivo;Can stimulate the secretion of gastric mucosa protective factor, maintain the complete form of gastric mucosa, significantly improve the level of stomach health for all-round protection and repair of damaged gastric mucosa.

This invention discloses the application of SLC10A3 as a target in the preparation of drugs for the prevention and / or treatment of gastric cancer, belonging to the field of biomedical technology. This invention discovers that the small interfering RNA of SLC10A3 exerts an anti-tumor effect by inhibiting the proliferation, invasion, and migration of gastric cancer cells and promoting ferroptosis. Inhibiting endogenous SLC10A3 in the SGC-7901 gastric cancer cell line can inhibit the proliferation, invasion, and migration of gastric cancer cells and promote ferroptosis. Combining the small interfering RNA of SLC10A3 with a suitable carrier to form a drug, and introducing it into gastric tissue or the body, will have preventive and therapeutic effects on gastric cancer. It is hoped that the small interfering RNA of SLC10A3 can be combined with chitosan, cholesterol, liposomes, nanoparticles, etc., to form drug molecules for the prevention and treatment of gastric cancer via oral, intravenous, intramuscular, or direct intragastric injection.