40 results about "Gastric Tissue" patented technology

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method and application thereof. According to the technical scheme, the traditional Chinese medicine composition is characterized by being prepared from, by weight, 10-50 parts of radix codonopsis, 5-20 parts of roasted rhizoma atractylodis macrocephalae, 5-10 parts of rhizoma pinellinae praeparata, 2-8 parts of rhizoma coptidis, 8-40 parts of poria cocos, 5-15 parts of radix salviae miltiorrhizae, 3-6 parts of rhizoma zingiberis, 5-15 parts of rhizoma cyperi, 1-20 parts of radix actinidiae chinensis and 1-5 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition provided by the invention can improve the pathological morphology of stomach tissues, increase the expression of PG I and the ratio of PG I to PG II, reduce the level of inflammatory factors and improve the atrophy degree of gastric mucosa, and is used for treating stomachache, distention and fullness, anorexia, gastric noisy and other symptoms caused by spleen and stomach qi deficiency, qi stagnation and blood stasis and damp-toxin interjunction of patients with chronic atrophic gastritis.

The invention belongs to the technical field of biological medicines, and relates to application of mannatide in preparation of a medicine for treating alcoholic gastric ulcer. The mannatide disclosed by the invention can be used for remarkably relieving gastric tissue hemorrhagic lesion and ulcer conditions of alcoholic gastric ulcer for the first time, and the mechanism comprises the following steps: reducing active oxygen generated by alcohol toxicity, and improving oxidative stress of a body by improving antioxidant enzyme activity of the gastric tissue; the inflammatory response of the organism is regulated by regulating and controlling an Akt / NF-kB pathway; a Bax-related apoptosis pathway is inhibited to protect gastric mucosa cells from alcohol-induced apoptosis, so that the integrity of gastric tissue mucosa is protected; the intestinal flora disorder caused by alcohol intake is regulated and controlled, and the acute alcoholic gastric ulcer is prevented by improving the intestinal flora composition of the alcoholic gastric ulcer. The application range of the mannatide is widened, and more solutions are provided for prevention or treatment of acute alcoholic gastric ulcer.

The invention belongs to the technical field of medicines, and particularly relates to application of fructus cinnamoii in preparation of a medicine for treating gastric ulcer. The invention discloses the application of the fructus cinnamoii oil in preparation of the gastric ulcer medicine for the first time, specifically, the fructus cinnamoii oil obviously improves the conditions of rat gastric mucosa bleeding, erosion, hyperemia, edema and the like and also obviously reduces the ulcer index of rat gastric tissues, and in addition, the fructus cinnamoii oil can be used for preparing the gastric ulcer medicine by reducing TNF-alpha, IL-6 and MDA. The contents of SOD and GSH are increased to improve the inflammatory reaction and oxidative stress of stomach tissues, so that the effect of protecting the stomach tissues of rats is achieved.

The invention relates to an image segmentation network method based on dual-path cross-latitude attention, and belongs to the technical field of medical image processing and deep learning. The method comprises the following steps: an input layer performs size adjustment and standardization processing on a stomach tissue pathological image; the encoder adopts a dual-path down-sampling architecture, combines a dual-path feature interaction mechanism, extracts multi-scale features through depth separable convolution and fuses the multi-scale features; the shallow jump connection layer extracts features based on a cross-latitude feature fusion mechanism by dividing cross dimension and standard space dimension branches and fuses the features to generate jump connection features; the decoder adopts an up-sampling architecture and is combined with a composite pooling attention enhancement mechanism to extract local features and generate decoding features; and the output layer outputs a lesion region segmentation result through single-channel convolution and an activation function. The accuracy and stability of lesion area segmentation of the stomach tissue pathological image are effectively improved, and reliable image analysis support is provided for clinical pathological diagnosis.

An implantable device for the treatment of acid reflux disease has a body including an outer surface adapted to rest against a patient's fundus wall. The device, when implanted in the patient, fills a volume in the patient's abdomen in the cardia area and above the cardia of the patient, when standing. The body prevents the cardia from moving through the diaphragm opening into the thorax, thereby preventing reflux by keeping the abdominal pressure supporting the cardia sphincter muscle. The device may be affixed to stomach tissue. The device may also be invaginated or otherwise indirectly secured in position.

The application provides application of a Baoji oral liquid composition in preparation of a functional dyspepsia medicine, and relates to the technical field of medicines. The application is based on the Baoji oral liquid, and it is found that the Baoji oral liquid has a remarkable effect on treating functional dyspepsia, especially cisplatin-induced functional dyspepsia. Specifically, the Baoji oral liquid can rapidly restore body weight, significantly improve body weight gain, steadily promote food intake, significantly improve gastric emptying rate and intestinal propulsion rate, protect the gastric mucosa layer, reduce inflammatory cell infiltration, repair the mucosa layer and muscle layer, improve the expression of serum gastrin and motilin, and improve the expression level of IL-4 in the gastric tissue and reduce the expression level of IL-1beta. The Baoji oral liquid has remarkable efficacy when applied in preparation of a functional dyspepsia medicine.

The present application relates to the technical field of medicine, in particular to a kind of drug composition for improving acute alcoholic gastric mucosal injury and application.The present application discloses the new medical use of ganoherbae decoction for the first time, and the composition can increase the activity of key enzyme in the stomach and liver tissue of acute alcoholic gastric mucosal injury mice, reduce the content of pro-inflammatory factor TNF-α in gastric tissue, increase the production of anti-inflammatory factor IL-10 in gastric tissue, reduce the inflammatory damage of ethanol to gastric mucosa, increase the level of protective factor EGF, SS and PGE-2 in serum, enhance the defense mechanism of gastric mucosa, and improve the repair ability of gastric mucosa.The discovery will have a significant impact on the research and treatment of acute alcoholic gastric mucosal injury disease, and has clinical practical value.

The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found.

The composition provided by the invention takes bear gall wood as a monarch drug and takes earthworm, bletilla striata, bighead atractylodes rhizome, Chinese yam and white paeony root as ministerial drugs, the earthworm and bletilla striata jointly play the effects of promoting blood circulation to remove meridian obstruction, dispersing blood stasis, removing stasis, astringing to stop bleeding and repairing injury, and the bighead atractylodes rhizome and Chinese yam are used as ministerial drugs and are used for strengthening spleen and stomach, replenishing qi and blood, providing fundamental power for the whole prescription and supporting healthy qi; liver softening, spasm relieving and pain relieving can be achieved; meanwhile, the traditional Chinese medicine composition has the effects of nourishing blood and astringing yin, can prevent other medicines in the formula from being too warm and dry or consuming yin blood, and forms dynamic and static combination compatibility with the minister medicine earthworm for promoting blood circulation to remove meridian obstruction; hairyvein agrimony, herba violae, vernonia graveolens, cuttlebone, mangnolia officinalis, semen raphani and endothelium corneum gigeriae A large number of pathological experiments prove that the traditional Chinese medicine composition can reduce stomach tissue inflammation, oxidative stress and activate apoptosis signal channels by acting on MAPK, PI3K-Akt and HIF-1 signals, so that the effect of treating chronic atrophic gastritis is achieved.

The invention relates to hybrid nano-clay and a preparation method and application thereof, the hybrid nano-clay comprises hybrid nano-clay particles with adhesive power, the hybrid nano-clay particles comprise nano-clay with the surface modified with a metal polyphenol network, and the metal polyphenol network is formed by self-assembly of Zn < 2 + > and tannic acid; the mass percent of the metal polyphenol network in the hybridized nano-clay particles is not less than 33%. The hybridized nano-clay particles provided by the invention have the capabilities of resisting oxidation, resisting bacteria and stopping bleeding; the gel can be adhered to stomach tissues, and free radicals in the body can be efficiently removed; the secretion of gastric mucosa protection factors can be stimulated, the complete form of the gastric mucosa is maintained, the damaged gastric mucosa is comprehensively protected and repaired, and the stomach health level is remarkably improved.

There is provided a gastric tissue tumour model that is three-dimensional comprising from 0.8 to 1.2 w / v % alginate, from 1.7 to 2.3 w / v % gelatin and gastric decellularized extracellular matrix (dECM). The gastric tissue model is for example an esophageal cancer tumour model which advantageously replicates the tumour microenvironment for esophageal cancer and can be used to perform a three-dimensional culture of esophageal tumour cells or metastatic cells that often metastasize into the esophagus.

An implantable device for the treatment of acid reflux disease has a body including an outer surface adapted to rest against a patient's fundus wall. The device, when implanted in a patient, fills a volume in the patient's abdomen in the cardia area and above the cardia of the patient, when standing. The body prevents the cardia from moving through the diaphragm opening into the thorax, thereby preventing reflux by keeping the abdominal pressure supporting the cardia sphincter muscle. The device may be affixed to stomach tissue. The device may also be invaginated or otherwise indirectly secured in position.

This application discloses the use of Panax notoginseng polysaccharide in the preparation of drugs for the prevention or treatment of alcoholic gastric ulcers. The research in this application shows that Panax notoginseng polysaccharide can reduce the area of ​​gastric ulcers, alleviate mucosal edema and congestion; the drug reduces the levels of GAS, IL-6, IL-10, and TNF-α and MPO activity in gastric tissue, and can be used in drugs and health products for the prevention or treatment of alcoholic gastric ulcers.

The invention belongs to the technical field of biological medicine, discloses nanocapsule-loaded in-situ gel for treating H. pylori infection and reversing intestinal metaplasia of gastric tissue and application of the nanocapsule-loaded in-situ gel, and particularly discloses nanocapsule-loaded in-situ gel which comprises a nanocapsule and pH-responsive gel, the nanocapsule is dispersed in the gel, and the pH-responsive gel is a pH-responsive gel. Comprising an active drug, a macromolecular substance for coating the active drug and a structure stabilizer. According to the nanocapsule-loaded in-situ gel provided by the invention, the nanocapsule-loaded in-situ gel is directionally released on one side by responding to the change of the pH value of an H.pylori infected part, and the nanocapsule responds to lipase secreted by H.pylori to accurately release an active drug, so that efficient sterilization is realized, and damage caused by infection is relieved. Meanwhile, the gel can also effectively reverse gastrointestinal metaplasia caused by H.pylori infection, further reduces the risk of gastric cancer, and provides a new thought for gastric cancer prevention.

The invention discloses a manufacturing method of a magnetic response millimeter-scale adhesion mobile robot for intragastric targeted drug delivery and pathological detection and the adhesion mobile robot. The method comprises the following steps: manufacturing a magnetic sheet with a simple harmonic magnetization curve; manufacturing a flexible frame, wherein a plurality of mounting holes for accommodating magnetic sheets are formed in the flexible frame; each magnetic sheet with a simple harmonic magnetization curve is mounted to a flexible frame, thereby forming a magnetic response millimeter-scale adhesion mobile robot for intragastric targeted drug delivery and pathological detection. According to the adhesion mobile robot manufactured through the method, the thin liquid film is transmitted on the wet and slippery surface through wave type movement of the magnetic response sheet-shaped soft material, so that crawling propelling is achieved by means of counter-acting force generated by the liquid film, the robot can stably crawl on the wet and low-friction stomach tissue surface by means of the adhesion moving characteristic, and the robot has a good application prospect. Good environmental adaptability is shown.

According to the present invention, strains for preventing gastric cancer have been identified and, in particular, it has been identified that when a microbiome was administered together with H. felis, which is known to cause various gastrointestinal diseases by inducing gastric tissue damage and inflammatory responses, gastric tissue damage and inflammatory responses did not occur. Furthermore, it has been identified that the microbiome suppresses gastric tissue damage when administered even in cases already infected with H. felis. Therefore, the microbiome can be effectively used as a preventive or therapeutic agent for normalizing gastric intestinal metaplasia, which is a precancerous lesion, and for suppressing gastric carcinogenesis.

The invention relates to the field of fungal polysaccharide application, and discloses a preparation method and application of morchella polysaccharide. The preparation method comprises the following steps: step 1) leaching dry morchella esculenta powder with water to obtain a leaching solution; carrying out alcohol precipitation on the leach liquor to obtain a precipitate; 2) adding water into the precipitate for redissolving, removing protein, and then dialyzing and freeze-drying to obtain a morchella esculenta crude polysaccharide extract; 3, the morchella esculenta crude polysaccharide extract is dissolved in water and purified through adsorption chromatography, and the morchella esculenta polysaccharide is obtained.The morchella esculenta polysaccharide has the protection effect on alcoholic stomach injury in vivo and in vitro, stomach tissue inflammatory response is adjusted by adjusting an NF-kb channel, and reference value is provided for development application of the morchella esculenta polysaccharide.

The invention belongs to the technical field of medicines, and provides a medicine capable of preventing and treating gastric ulcer. Evaluation of the acute gastric ulcer treatment effect of early chick embryo amniotic fluid finds that the early chick embryo amniotic fluid can reduce the gastric tissue ulcer area and inflammatory factor infiltration, and the protective effect of the mucosal barrier on the gastric tissue is enhanced by reducing the calcium ion content in the gastric tissue and myeloperoxidase, so that the gastric ulcer treatment effect is improved. In addition, the oxidative stress level caused by ethanol is obviously inhibited, and the level of tight junction protein of stomach tissue is up-regulated. The invention has the potential of treating gastric ulcer.

It has been identified in the present invention that, in addition to Helicobacter felis, strains causing cell hyperplasia, metaplasia, dysplasia, and the like in gastric tissues. Therefore, a gastric cancer mouse model in which gastric lesions are induced in mice can be provided using a gastric microbial transplantation (GMT) technology, and various gastrointestinal diseases can be diagnosed and the prognosis thereof can be predicted by measuring the concentrations of the strains.

The invention discloses a construction method of a chronic atrophic gastritis precancerous lesion animal model, and the construction method comprises the following specific steps: selecting experimental mice, randomly and averagely dividing the experimental mice into a model group and a blank control group, the experimental mice of the model group drink an MNU solution I by themselves and use an MNU solution II for intragastric administration once a week, and the blank control group normally diets; after modeling, dissecting and taking stomach tissues for later use; the MNU solution I is an N-nitroso-N-methylurea solution with the concentration of 290 mg / L to 310 mg / L; the MNU solution II is an N-nitroso-N-methylurea solution with the concentration of 1.6 g / L to 1.7 g / L; according to the method, 14-week modeling can be achieved, intestinal metaplasia, heterodysplasia and even a small number of cancer cells can occur in 14 weeks, and compared with a traditional MNNG combined multi-factor modeling method, the modeling method has the advantages that the modeling method is simplified, experimental errors and individual differences are reduced, the modeling period is shortened, and the modeling success rate is increased.

Stomach tissue is manipulated and fastened with a tissue grasper and a tissue shaper to form folds in the stomach. The tissue grasper and the tissue shaper rotate and translate relative to one another. The tissue grasper has a plurality of vacuum orifices to adhere the tissue grasper to tissue.

The method comprises the following steps: weighing 40 g of coptis chinensis decoction pieces, 30 g of dried ginger, 30 g of licorice roots, 30 g of cassia twigs, 25 g of Chinese dates, 25 g of pinellia ternate and 20 g of ginseng, crushing the materials into coarse powder, sieving the coarse powder, adding 70% ethanol, and soaking the coarse powder for a period of time; heating to a boiling state, keeping a slight boiling state, refluxing for 1 hour, stirring once every 15 minutes, filtering while the solution is hot, and reserving residues; adding 70% ethanol again, timing after boiling, refluxing for 1 hour, filtering and combining the two filtrates; and concentrating the filtrate into thick extract without ethanol smell, and preparing freeze-dried powder by adopting a freeze-drying process. The preparation method is high in powder yield. The freeze-dried powder prepared by the invention can obviously reduce serum inflammatory factors (IL-1beta and IL-6), improve gastric mucosa atrophy (GAST, PGA / PGC indexes) and inhibit gastric tissue pathological damage, and can be used for reversing gastric precancerous lesions.

The present invention discloses a composition having an auxiliary protective function for gastric mucosal damage and its application, belonging to the application field of medicinal and edible compositions. The composition comprises the following components in parts by weight: 6 to 12 parts of ginseng, 18 to 30 parts of lotus seeds, and 60 to 90 parts of lotus roots. Based on the theory of traditional Chinese medicine, the present invention uses ginseng, lotus seeds, and lotus roots as raw materials, and the three are combined in proportion to have a significant synergistic effect in auxiliary protection of gastric mucosal damage. Animal experiments have shown that the composition of the present invention can reduce the MDA content in animal serum, increase SOD activity, have a protective effect on gastric mucosal damage, increase the NO and PGE2 content in animal gastric tissue, and reduce gastric mucosal damage. The composition of the present invention is of great significance for the development of health products for auxiliary protection of gastric mucosal damage and drugs for treating gastric mucosal damage.

The invention relates to the technical field of health-care products, and discloses a hawthorn chewable tablet with an appetizing effect and a preparation method thereof.The hawthorn chewable tablet is formed by taking hawthorn powder as a main component and taking litsea cubeba essential oil coated freeze-dried powder, vitamin C, a flavoring agent and the like as auxiliary components through mixing, the Litsea cubeba essential oil can be adhered to the stomach wall to achieve the effect of continuously releasing the Litsea cubeba essential oil at a gastric ulcer target site, the antibacterial and anti-inflammatory effects of the Litsea cubeba essential oil can facilitate the repair of gastric tissues, and the Litsea cubeba essential oil can also regulate gastric acid secretion, so that further damage of excessive gastric acid to gastric mucosa is avoided; therefore, a good treatment effect on gastric ulcer is achieved.

The present invention provides a hyperthermia-induced gut microbiome- mediated modulation of the host immune system for the treatment of gastric / gastric MALT / Duodenum cancer; the said system uses a wild type / non-pathogenic / attenuated strain coated with iron oxide nanoparticles to specifically target the cancerous tissue by applying an external field around the gastric tissue the said iron oxide generates heat on bacteria surface and causes lysis of bacteria in the tumor microenvironment; the lysis of bacteria triggers various potent immune activator and cytokines to activate antigen-presenting cells including lymphocytes and macrophages; the said antigen presenting cell further, eliminates cancer cell from the gut microenvironment and eventually clean tumor microenvironment. Additionally, the activated lymphocytes will be antigenic memory against bacterial particles and cancer tissues. Furthermore, the said treatment system does not involve the use of any chemotherapeutic drug or radiation treatment and, thus, precludes undesirable side effects of chemotherapy as well as minimizes toxicity.

The invention discloses a composite probiotic agent and application thereof in treatment of helicobacter pylori infection. The compound probiotic agent is prepared from lactobacillus gasseri, lactobacillus rhamnosus and bifidobacterium animalis subsp. Lactis. The compound probiotic agent disclosed by the invention has a high inhibition rate on helicobacter pylori, and can effectively improve gastric tissue damage and systemic inflammatory response caused by helicobacter pylori infection.

A method of endoscopically reconstructing a stomach includes passing an end effector of an intraluminal treatment device through an esophagus and into a stomach; directing the end effector to a position adjacent a fold extending from a lesser curvature of the stomach; grasping the fold between a first jaw and a second jaw of the end effector; deploying fixation elements from the end effector and into the fold; and cutting through the fold adjacent to the fixation elements so as to form a passageway through the fold.

The present invention relates to an application of primers for detecting tRF-28 expression in tissues in the preparation of a gastric cancer auxiliary diagnosis kit, characterized in that: the nucleotide sequence of the tRF-28 is as shown in SEQ ID NO: 1, and the expression of the tRF-28 is specifically downregulated in gastric cancer patient tissues: the primers are: F1: 5'-CTCCCGGTTGGCTTCCTAAG-3'; R1: 5'-GGTACCTCCTCTCTTCTCTACT-3'. Compared with the prior art, the advantage of the present invention is that the specifically downregulated tRF-28 in gastric cancer tissues can be used as a new molecular marker for gastric cancer diagnosis.

The utility model relates to medical supplies technical field, especially a kind of gastrointestinal postoperative nursing device, including abdominal belt, the front end middle part of abdominal belt is fixedly connected with nursing assembly, the left part and the right part of front end of abdominal belt are fixedly connected with connecting band, the front end of two connecting bands is fixedly connected with several silica gel balls, the left end of abdominal belt is fixedly connected with first fixed band, the right end of abdominal belt is fixedly connected with second fixed band, the outside of first fixed band and second fixed band is fixedly connected with elastic component, the outside of two elastic components is fixedly connected with fixed component with together.The utility model relates to a kind of gastrointestinal postoperative nursing device, the inflatable nursing pad in nursing assembly can be inflated according to patient's demand adjustment, the nursing pad after proper inflation can form accurate local compression to surgical site, play the effect of hemostasis, alleviate swelling, while providing buffer protection for fragile postoperative gastrointestinal tissue, avoid direct impact of external force.

The invention belongs to the field of medical image processing and analysis, and relates to a gastric ulcer detection computer method based on image processing and deep learning. According to the method, an advanced image labeling technology, deep learning model training and recognition and a user interaction interface are combined, and automatic and accurate stomach tissue image analysis is realized through a deep learning technology, so that the limitation of a traditional manual measurement and software analysis method is solved, and the gastric ulcer research efficiency and accuracy are greatly improved.