9 results about "Motilin" patented technology

The invention provides a traditional Chinese medicine composition for improving spleen and stomach health and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 to 30 parts of rhizoma dioscoreae, 15 to 20 parts of rhizoma atractylodis macrocephalae, 8 to 15 parts of fructus aurantii, 10 to 15 parts of red dates, 8 to 12 parts of liquorice root, 10 to 15 parts of inulin, 6 to 10 parts of fructus amomi and 5 to 8 parts of cassia twig. The lauric acid modified fenugreek gum (LA-FG) is used as an emulsifier and an immobilized enzyme carrier to construct a water-oil two-phase enzymolysis system, so that the content of effective active ingredients in the traditional Chinese medicine composition, the product stability and the bioavailability are remarkably improved. In addition, the traditional Chinese medicine composition can effectively improve the gastric emptying rate and the small intestine propulsion rate, the level of motilin and anti-inflammatory factors IL-10 is improved, and the effect of improving spleen and stomach health is achieved through multi-target-point synergism. The method successfully breaks through double limitations of a traditional process and an existing scheme, effectively considers volatile oil protection, efficient enzymatic conversion and system stability, and provides a new path for promoting technical upgrading of the traditional Chinese medicine industry.

The application relates to a composition for treating reflux esophagitis and application thereof. The composition comprises the following components in parts by weight: 2-8 parts of scutellaria baicalensis, 3-7 parts of licorice, 5-10 parts of beeswax and 80-120 parts of vegetable oil. The composition for treating reflux esophagitis contains scutellaria baicalensis, licorice, beeswax and vegetable oil, and through mutual cooperation among the components, the drug prepared from the composition can significantly increase the plasma motilin level of a patient, further increase the pressure of the lower esophageal sphincter, promote gastric emptying and prevent acid reflux, promote the recovery of reflux esophagitis, the esophagus of the patient is obviously improved, and no adverse reaction is found; meanwhile, the content of lipid peroxide can be obviously reduced, the activities of superoxide dismutase and glutathione peroxidase are increased, the esophageal mucosa is protected and treated, the pathological changes of the esophagus are obviously improved, and the treatment effect is excellent.

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

The invention relates to the technical field of biological medicines, in particular to a natural polysaccharide composition and application thereof in preparation of a product for relieving constipation by promoting peristalsis. The natural polysaccharide composition comprises mint polysaccharide and astragalus polysaccharide; wherein the mass ratio of the mint polysaccharide to the astragalus polysaccharide is 1: (1-30). Researches show that the natural polysaccharide composition obtained by combining the mint polysaccharide and the astragalus polysaccharide has the effect of promoting motilin secretion remarkably higher than that of single mint polysaccharide or astragalus polysaccharide; the synergistic interaction effect is achieved. The natural polysaccharide composition disclosed by the invention has the effect of promoting motilin secretion, so that the natural polysaccharide composition can further play a role in promoting peristalsis and further play a role in relieving constipation; the important application value is realized.

The invention belongs to the technical field of medical application, and particularly relates to a traditional Chinese medicine application for improving gastrointestinal discomfort and a preparation method thereof. The traditional Chinese medicine patch for improving gastrointestinal discomfort comprises the following raw materials in parts by weight: 20-25 parts of clove, 18-22 parts of codonopsis pilosula, 13-18 parts of semen raphani, 10-15 parts of linaria lingua, 5-10 parts of pinellia ternate, 9-13 parts of fingered citron, 6-11 parts of maple and 3-8 parts of liquorice. The traditional Chinese medicine prescription provided by the invention is safe, non-toxic and mild in medicine property, and can tonify without stagnation and warm without dryness. The traditional Chinese medicine patch disclosed by the invention can regulate the gastrointestinal hormone level and promote motilin secretion, so that the gastric emptying rate and the small intestine propulsion rate are improved, the gastrointestinal motility is enhanced, the digestive function is improved, and the traditional Chinese medicine patch shows good potential in the aspect of improving gastrointestinal discomfort.

The invention belongs to the technical field of biological medicine, and particularly relates to a protein composition and a preparation method thereof. The protein composition is prepared from the following components in parts by weight: 10 to 20 parts of autoblood immune stimulator and 1 to 5 parts of Motilin analogue polypeptide TCL1, the amino acid sequence of the polypeptide TCL1 of the Motilin analogue is as shown in SEQ ID NO. 1. Test results show that by injecting the protein composition prepared by the invention, the immune state can be reversed from pro-inflammatory Th1 type to anti-inflammatory Th2 type reaction, a key immune microenvironment is created for beta cells, and the insulin secretion ability is improved, so that the blood sugar level is reduced, the treatment effect on diabetes is remarkable, and the protein composition has a wide application prospect.

The invention relates to the technical field of biological medicines, in particular to a composition and application thereof in preparation of a product for relieving constipation by promoting peristalsis. The composition comprises a honeysuckle flower extract and a hawthorn fruit extract, wherein the mass ratio of the honeysuckle extract to the hawthorn extract is 1: (1-80). Researches show that the composition obtained by combining the honeysuckle flower extract and the hawthorn fruit extract prepared by the method disclosed by the invention has the effect of promoting motilin secretion remarkably higher than that of the single honeysuckle flower extract and hawthorn fruit extract, and plays a synergistic effect. The composition disclosed by the invention has the effect of promoting secretion of motilin, so that the composition can further play a role in promoting peristalsis and further play a role in relieving constipation; the important application value is realized.

This invention belongs to the field of biomedical technology, specifically relating to a protein composition and its preparation method. The protein composition comprises the following components in parts by weight: 10-20 parts of autologous blood immunostimulant and 1-5 parts of Motilin analog peptide TCL1; the amino acid sequence of the Motilin analog peptide TCL1 is shown in SEQ ID NO.1. Experimental results show that injection of the protein composition prepared according to this invention can reverse the immune status from a pro-inflammatory Th1 type to an anti-inflammatory Th2 type response, creating a crucial immune microenvironment for β cells, improving insulin secretion capacity, thereby reducing blood glucose levels, and demonstrating significant therapeutic effects on diabetes with broad application prospects.

This invention discloses the application of Amomum villosum extract in the preparation of drugs for the prevention and treatment of functional dyspepsia, belonging to the field of biotechnology. The extract, when applied to the prevention and / or treatment of functional dyspepsia, can increase plasma levels of motilin (MTL) and gastrin (GAS), promote gastrointestinal motility, significantly improve gastric emptying rate in functional dyspepsia model mice, improve pathological damage to gastric tissue, restore mitochondrial function in gastric tissue, and regulate the expression of related factors in gastric tissue. Even at low doses, it can effectively increase plasma MTL and GAS levels in loperamide hydrochloride-induced functional dyspepsia model mice, improve gastric emptying rate, effectively improve pathological damage to gastric tissue in these mice, and regulate the expression of related factors in the gastric tissue. The raw materials of this invention are derived from natural products, are easy to collect, and have high safety.