3 results about "Enkephalin" patented technology

The present application relates to a method for synthesizing leu-enkephalin by Fmoc method, which uses Fmoc-protected amino acid as monomer, and sequentially connects amino acid to resin. In the synthesis of leu-enkephalin, all the amino acids do not have any side chain protection group. The Fmoc protection group is removed by using a solution of 1.00 mol / L imidazole and 0.02 mol / L tricyclohexylphosphine in tetrahydrofuran, and finally leu-enkephalin is obtained by removing the resin with aqueous trifluoroacetic acid. The present application first uses imidazole and tricyclohexylphosphine as components of Fmoc deprotection agent, instead of traditional pyridine. The deprotection agent is not controlled by "controlled chemicals", is cheap and easy to obtain, is stable in nature, and is low in toxicity, volatility and corrosion. The deprotection agent has excellent Fmoc removal ability, does not cause phenolic ring acylation side reaction of tyrosine side chain, does not need any side chain protection, simplifies the production process of polypeptide, reduces the preparation cost of polypeptide, and provides great improvement space for the design of synthesis strategy of polypeptide containing basic sensitive side chain protection group.

The invention provides an active peptide composition for regulating emotion and improving side effects of drugs, and relates to the technical field of active peptide compositions. The active peptide composition provided by the invention comprises an emotion regulating component and a nerve recovery promoting component, the emotion regulating component comprises theanine, gamma-aminobutyric acid (GABA), a perilla leaf extract, nano curcumin and a black pepper extract, and the components have a synergistic effect to jointly inhibit depression and central nervous system hyperexcitation and regulate emotion; the nerve recovery promoting component comprises N-acetylneuraminic acid, phosphatidylserine, brain peptide VVAVP and a perilla leaf extract, and the components cooperate with one another, so that brain recovery is promoted, anxiety is reduced, and memory is improved; the emotion regulating component and the nerve recovery promoting component cooperate with each other, the dosage of the components is optimized, depression and central nervous hyperexcitation are jointly inhibited, emotion is regulated, brain recovery is promoted, anxiety is reduced, memory is improved, the digestion and absorption effects are good, and burden on intestines and stomach is small.

The present invention relates to: an improved small molecule compound having excellent cereblon (CRBN)-binding activity and enhanced anticancer activity; and a use thereof. The compound according to the present invention can effectively act as a novel anticancer agent for the treatment of various solid cancers and blood cancers on the basis of the binding affinity to cereblon.