20 results about "Bone epiphysis" patented technology

The invention provides a controllable degradation magnesium-based bionic biphasic stent as well as a preparation method and application thereof. The stent comprises a porous magnesium stent, hydrogel and a ceramic coating, the porous magnesium scaffold comprises a cartilage phase scaffold and a subchondral bone phase scaffold which are arranged from top to bottom; hydrogel is arranged on pores and the outer surface of the cartilage phase scaffold, and a ceramic coating is arranged on the surface of the subchondral bone phase scaffold. From the bionic angle, the three-dimensional communicated porous magnesium stent with gradient porosity is designed by simulating the structure, mechanics and other characteristics of joint tissues (upper cartilage and lower subchondral bone); meanwhile, according to the characteristics of joint tissue components, biological properties and the like, hydrogel (an upper cartilage phase) is filled in the stent, and a bioactive ceramic coating (a lower subchondral bone phase) is prepared on the surface of the stent, so that the degradation rate of the biphasic magnesium stent is regulated and controlled, and the cytotoxicity is reduced; meanwhile, the biocompatibility and the biological activity are improved, and endogenous cartilage-subchondral bone integrated repair is realized.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the femorotibial joint, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

A method for modeling temporomandibular joint osteoarthritis, 6-week-old rats are selected, the rats are confirmed to have entered an anesthetized state before surgery, the rat's mandibular incisors are first checked and confirmed to be normal, the first arm of the device is sleeved on one side of the mandibular incisor, and the palatal side of the maxillary incisor is made to touch the slope surface of the second arm of the device, the device is checked and confirmed to not affect the rat's mandibular movement and occlusion, not significantly raise the bite, have no early contact, and the upper and lower jaw relationship is relatively stable; the device and the mandibular incisor sleeved with the device are fixed; then the rat is put back into the cage, and soft food or powdered feed is given after waking up; the device is removed after being fed for 8 weeks or more. It is verified that the condylar process of the rat changes significantly, the overall condylar process is significantly reduced, the subchondral bone is destroyed, and the expression of the cartilage matrix is also reduced. Thus, a TMJOA rat model exhibiting mandibular retrusion is formed.

The invention discloses an RIP3-mediated osteoarthritis animal model as well as a construction method and application thereof. The construction method comprises the following steps: delivering an effective dose of a genetic tool (such as an adenovirus vector) capable of expressing RIP3 protein into a knee joint subchondral bone area of an experimental animal, and realizing continuous overexpression of RIP3 through regular operation, so as to induce pathological characteristics highly similar to human osteoarthritis. The model stably shows typical OA phenotypes such as limb pain sensitization, subchondral bone loss and bone microstructure degeneration, osteoclast number increase and overlying cartilage degeneration. The invention reveals that the natural process of occurrence and development of the osteoarthritis can be directly simulated through specific overexpression of the RIP3 in the subchondral bone for the first time, and a brand-new and valuable tool is provided for researching the pathogenesis of the osteoarthritis and screening and evaluating medicines and therapies for treating the osteoarthritis.

A glenoid implant including a base plate and an articular component. The base plate can include a body and a support structure extending from a distal surface of the body. The body can include a plurality of openings. The articular component can be configured to removably couple to the base plate. The articular component can include a recessed portion configured to at least partially receive the body of the base plate. At least one engagement structure can protrude from a distal facing surface of the recessed portion. Each engagement structure can correspond to one of the plurality of openings in the body. A distal face of the articular component surrounding the recessed portion can be configured to abut the subchondral bone.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused 2024 / 064830 by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the metatarsal phalangeal joint or other joint of the foot or ankle, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.WO

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

An adaptive porous femoral head necrosis support rod comprises a head, a body, a temperature-sensitive bone conduction layer and a tail; the head, the body and the tail are coaxially connected in sequence, and the temperature-sensitive bone conduction layer covers the surface of the body; the shape of the head matches the cavity surface left after the removal of dead bone, and the head and the body are both porous structures; the tail is provided with a thread, and the thread groove is provided with a porous structure. The porous personalized adaptive femoral head necrosis support rod has strong personalized adaptation. The shape of the head matches the cavity surface left after the removal of dead bone in the patient's marrow core, can maximize the contact area of the head and the patient's subchondral bone, improve the ability of the support rod to resist pressure and support the subchondral bone, and effectively prevent collapse.

The invention discloses a double-layer piezoelectric hydrogel scaffold for realizing articular cartilage injury repair through ultrasonic regulation, the piezoelectric hydrogel scaffold comprises a scaffold upper layer for cartilage repair and a scaffold lower layer for subchondral bone repair, the upper layer and the lower layer both comprise a colloid component and a piezoelectric component, wherein the mass percent concentration of piezoelectric components in the upper layer of the piezoelectric hydrogel stent is lower than that of piezoelectric components in the lower layer of the piezoelectric hydrogel stent. The mechanical property and gradient piezoelectric property of the double-layer piezoelectric hydrogel scaffold are matched with articular bone cartilage tissue regeneration, and cartilage-bone synergistic regeneration can be accurately regulated and controlled. The novel bionic hydrogel scaffold can significantly improve articular cartilage injury, and has a wide clinical application prospect.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the humeroradial joint or other joint of the elbow, wrist, or hand, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

A glenoid implant including a base plate and an articular component. The base plate can include a body and a support structure extending from a distal surface of the body. The body can include a plurality of openings. The articular component can be configured to removably couple to the base plate. The articular component can include a recessed portion configured to at least partially receive the body of the base plate. At least one engagement structure can protrude from a distal facing surface of the recessed portion. Each engagement structure can correspond to one of the plurality of openings in the body. A distal face of the articular component surrounding the recessed portion can be configured to abut the subchondral bone.

The invention belongs to the technical field of bone tissue engineering and regenerative medicine, and particularly discloses a piezoelectric-photo-thermal dual-mode composite stent for articular cartilage repair and a preparation method of the piezoelectric-photo-thermal dual-mode composite stent. The preparation method comprises the three steps of MXene preparation, electrostatic spinning and paper folding structure construction, poly-L-lactic acid and MXene nanosheets are compounded to prepare a fiber membrane, and then the fiber membrane is subjected to hot pressing through a corrugated mold to form the three-dimensional stent with the periodic creased structure. The scaffold has piezoelectric property and photo-thermal property at the same time, promotes cartilage differentiation through the piezoelectric effect, inhibits subchondral bone angiogenesis through the photo-thermal effect, maintains a low-oxygen microenvironment, realizes integral repair of cartilage-subchondral bone functional units, can be used for treatment of cartilage defects, osteochondral defects and osteoarthritis, and has a wide application prospect. The problem that the cartilage steady state is damaged due to the fact that a traditional piezoelectric material promotes bone vascularization is solved.

The application provides a kind of osteochondral tissue repair scaffold and its preparation method.The osteochondral tissue repair scaffold is made by self-made photo-curing 3D printing equipment integration, including bionic double-layer structure: cartilage layer and subchondral bone layer, cartilage layer has "lotus root-like" and "radiation-like" hole, subchondral bone layer has "lotus root-like" hole, and longitudinal interstices between cartilage layer and subchondral bone layer are mutually through, aperture is accurately controlled, and also can add calcium phosphate nanocluster material with 1 nanometer particle size in subchondral bone layer.The osteochondral tissue repair scaffold prepared by the application aims at the different tissue characteristics and regeneration requirements of cartilage and subchondral bone, designs double-layer scaffold with different physical and biological characteristics, simulates the anisotropy of natural osteochondral structure, promotes cell migration and tissue growth, and achieves the effect of promoting synchronous regeneration of cartilage and subchondral bone, so it has great application potential.

This invention relates to the field of biomedical technology, specifically providing a product for the treatment and diagnosis of osteoarthritis (OA) targeting Y-box-binding protein 1 (YBX1) and its applications. The method utilizes a recombinant adeno-associated virus (AAV) vector to deliver a YBX1 interference sequence, which is then injected locally into the knee joint to specifically target subchondral bone marrow macrophages (BMMs). Experiments have demonstrated that this method effectively inhibits osteoclast differentiation of BMMs, alleviates pain in OA model mice, improves abnormal bone remodeling and bone loss in the subchondral bone, and delays degeneration of the overlying cartilage, while exhibiting good biocompatibility. This invention provides a novel strategy and drug candidate for the etiological treatment of OA.

A photocurable 3D-printed bioceramic osteochondral scaffold, comprising a cartilage repair layer and a subchondral bone repair layer that are formed of the same material, wherein the cartilage repair layer has a porous structure having a first pore size, and the first pore size is 100-1000 µm; the subchondral bone repair layer has a porous structure having a second pore size, and the second pore size is 300-1000 µm; the cartilage repair layer and the subchondral bone repair layer interdigitate at the interface to form a porous structure having a third pore size, and the third pore size is 50-300 µm; the third pore size is less than the first pore size and the second pore size. The osteochondral scaffold can not only ensure the infiltration of bone marrow blood carrying bioactive substances such as bone marrow mesenchymal stem cells and growth factors into cartilage defect sites, but also prevent vascular invasion from the subchondral bone repair layer, thereby inhibiting calcification of the cartilage layer; and the subchondral bone repair layer provides sufficient support for the repair of the cartilage layer during the repair process.

The invention relates to the technical field of biological medicines, and particularly provides a Y-frame binding protein 1 (YBX1)-targeted osteoarthritis treatment and diagnosis product and application thereof. According to the method, a YBX1 interference sequence is delivered by using a recombinant adeno-associated virus (AAV) vector, and subchondral bone marrow macrophages (BMMs) are specifically targeted through knee joint local injection. Experiments prove that the method can effectively inhibit osteoclast differentiation of BMMs, relieve pain of OA model mice, improve abnormal bone remodeling and bone loss of subchondral bones and delay degeneration of overlying cartilage, and shows good biological safety at the same time. The invention provides a new strategy and drug candidate for etiological treatment of OA.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the glenohumeral joint or other joint of the shoulder, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

The invention provides an osteochondral repair scaffold based on an extremely small curved surface, and belongs to the field of tissue engineering repair materials, the scaffold comprises a cartilage repair layer and a subchondral bone repair layer which are made of the same material, and the cartilage repair layer and the subchondral bone repair layer are both of an extremely small curved surface bionic porous structure. And the bionic porous structures of the cartilage repair layer and the subchondral bone repair layer are in continuous smooth transition at the junction of the two layers. Furthermore, the pore diameter and the pore wall thickness of the subchondral bone repair layer are gradually changed in a gradient mode in the longitudinal axis direction of the stent. The problems of interface layering, incompatibility of mechanical properties and pore structures and the like of a multi-layer bracket are solved.

Systems, methods, and compositions directed to the engineered incorporation of a tidemark-mimetic into a 3D printed osteochondral (OC)-mimetic hydrogel scaffold configured to recapitulate a mineralized barrier that restricts transport of calcifying ions into the articular (hyaline) cartilage layer, and / or an engineered cement line-mimetic configured to prevent cellular migration from the subchondral bone layer into the cartilage layers.