47 results about "Synovial fluid" patented technology

The invention relates to the technical field of online detection and analysis, and discloses a bone joint synovial fluid detection and analysis system based on microfluidics, which specifically comprises the following steps: acquiring synovial fluid rheological data and synovial fluid molecular activity data in a bone joint movement process and cartilage surface morphological data in a joint buckling process through a biosensor; constructing a synovial fluid dynamic anomaly analysis model, and performing synovial fluid function anomaly analysis through the synovial fluid rheological data and the molecular activity data; a cartilage stress anomaly analysis model is constructed, and cartilage stress anomaly analysis is carried out through cartilage surface morphological change data; obtaining a synovial fluid function abnormality analysis result and a cartilage stress abnormality analysis result to carry out bone joint function adaptability analysis; and acquiring a bone joint function adaptability analysis result and carrying out synovial fluid function abnormality analysis early warning. The problem that in the prior art, due to the fact that the bionic degree of a detection strategy is insufficient and bone joint dynamic parameters are deficient, the association degree of a static synovial fluid detection result and the actual joint rehabilitation condition of a patient is poor is solved.

The invention belongs to the field of pet food processing, and relates to a premix for improving joint health of pets and a preparation method thereof. The premix is added with the following natural components: rhizoma polygonati, rhizoma drynariae, eucommia ulmoides, ligusticum wallichii, liquorice, turmeric, poria cocos and Chinese yam. The whole formula has the effects of tonifying liver and kidney to consolidate the root, promoting blood circulation to remove meridian obstruction to treat symptoms, tonifying spleen to remove dampness to assist transportation and transformation, tonifying spleen to prevent dampness stagnation, promoting diuresis to prevent positive qi injury, treating both symptoms and root causes, combining dredging and tonifying, and directly reaching the effects on joints. The premix can tonify cartilage, strengthen ligament, relieve pain, supplement synovial fluid, effectively improve the arthritis health of pets and improve the life quality of pets.

A temporomandibular joint replacement system includes an insert configured to be disposed on an articular surface of a temporomandibular joint, a biocompatible fluid including a synthetic synovial fluid, a porous condyle configured to contain the biocompatible fluid and to be disposed on an opposing surface of the temporomandibular joint, and a sensor disposed along a top surface of the insert.

The present invention relates to pharmacogenetics, more specifically to strategies involving biomarkers associated with the clinical response to a compound before or during treatment of a cartilage disorder, such as osteoarthritis. The present invention more particularly relates to the combination of JSW measurements and level of specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used in strategies such as patients' enrichment in clinical trials, patients' selection strategy before or during treatment or for adapting the treatment of a patient in the frame of treatments for cartilage disorder, such as osteoarthritis.

The present invention relates to a hydrogel composition for intra-articular administration, which is easily injected into the human body, and use thereof for supplementing joint synovial fluid, supplementing viscosity, and preventing or treating intra-articular lesions. The hydrogel composition according to the present invention can improve the gelation temperature, viscosity, biodegradability, and tissue support capability of hyaluronic acid and, at the same time, can improve practitioner convenience and patient compliance due to the reduced injection pressure thereof. In addition, the hydrogel composition can increase the effect of ameliorating intra-articular lesions when co-administered with stem cells or exosomes, and thus can have various applications in medical devices and pharmaceutical fields for the purpose of cartilage regeneration and intra-articular lesion treatment.

Disclosed are methods for detecting extracapsular synovial fluid or components thereof as a marker for initiation of processes that lead to degenerative joint disease in a subject.

The present invention discloses an application and a kit for differential histoproteins and / or metabolites of pigmented villonodular synovitis; the differential histoproteins include at least one of the following proteins: TNFSF11, cathepsin K, and adhesion G protein-coupled receptor E5; the differential metabolites include at least one of the following products: 13-hydroxyperoxylinoleic acid and octadecadienoic acid; the present invention provides a new screening marker for pigmented villonodular synovitis (PVNS) through proteomics and metabolomics, which can achieve effective screening for pigmented villonodular synovitis; the obtained screening marker is used in a screening kit, which only needs synovial fluid as a test sample, can quickly perform screening and detection, and has the advantages of high efficiency and simple detection.

The present invention relates to biomarkers associated with the clinical response to an FGF-18 compound before or during treatment of a cartilage disorder. The present invention more particularly relates to specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used for the diagnosis and treatment of cartilage disorders. The invention further discloses specific proteins that are related to cartilage response to an FGF-18 compound treatment as well as diagnostic tools and kits based on their expression profile. Thus, the invention can be used in predicting the response to an FGF-18 compound treatment, before starting the treatment with FGF-18 or during the treatment. It could be used for selecting / identifying subjects to be treated by intra-articular administration of an FGF-18 compound. The use of these biomarkers in diagnostics could result in increased benefit and reduced risk in subjects.

To provide a method for restoring the synovial surface properties of a synovial surface film that has been damaged and whose synovial surface properties have deteriorated. [Solution] A method for restoring the synovial surface properties of a synovial surface film, comprising a standing step of allowing the damaged synovial surface film, whose synovial surface properties have deteriorated, to stand for more than 5 minutes, wherein the synovial surface film is a synovial surface film containing a liquid organic compound at 25°C and 1 atm.

The invention relates to the technical field of biomedical materials, in particular to double-responsiveness hydrogel as well as a preparation method and application thereof. The invention provides a dual-responsiveness injectable hydrogel. The dual-responsiveness injectable hydrogel comprises oxidized hyaluronic acid (OHA) and hyaluronic acid-3-aminophenylboronic acid (HA-PBA), the OHA and the HA-PBA are connected through a Schiff base bond; hA and PBA in the HA-PBA are connected through a boric acid ester bond. The hydrogel has ROS (reactive oxygen species) and pH (potential of hydrogen) double responsiveness due to existence of borate bonds and Schiff base bonds, and is suitable for being used as a carrier of a rheumatoid arthritis drug delivery system; hyaluronic acid is a main component of synovial fluid and is beneficial to relieving pain of a patient suffering from rheumatoid arthritis; the hydrogel is simple in used raw materials and simple and convenient in preparation process, and is expected to be applied to local drug delivery of rheumatoid arthritis and other pathological microenvironment diseases with high active oxygen or low pH.

The invention provides methods and systems for detecting a biomarker in a synovial fluid wherein the system also includes a control to ensure that the test sample is indeed synovial fluid. The biomarkers and the control for synovial fluid can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.

The present application relates to the technical field of genetic testing, and discloses a sample diluent, a sample preparation method, and a rheumatoid arthritis test kit. The sample diluent comprises the following concentrations of components: 5-40 g / L of an alkali metal salt, 1-20 g / L of a protein protectant, 5-50 mM of an alkyl glycoside surfactant, 0.01-0.1% of a Tween surfactant, 1-100 μg / mL of an immunoadsorbent, and 10-200 mM of a buffer, wherein the pH value of the buffer ranges from 6.5 to 8.0. The present application provides an actual basis for synovial fluid testing in clinical rheumatoid arthritis, and takes into account a small sample size, such as testing of a site where synovial fluid is difficult to aspirate. In addition, by using an iFlash series instrument, a result can be obtained in as little as 10 min. Compared with the operating time of at least 1 hour of conventional ELISA, the test process is greatly accelerated, and high sensitivity and specificity are achieved.

The invention provides an injectable magnesium-loaded lipid-based super-lubricating hydrogel microsphere, an articular cavity injection preparation and a preparation method of the injectable magnesium-loaded lipid-based super-lubricating hydrogel microsphere. The method comprises the following steps: S1, preparing a magnesium-loaded multilayer vesicular liposome suspension containing magnesium ions; s2, preparing a non-crosslinked magnesium-containing hydrogel; and S3, mixing the magnesium-loaded multilayer vesicular liposome suspension and the magnesium-containing hydrogel to prepare hydrogel liquid drops, and carrying out crosslinking to form the magnesium-loaded lipid-based super-lubricating hydrogel microspheres. The magnesium loading amount of the lipid-based super-lubrication hydrogel microspheres can be greatly improved; on one hand, the biological function provided by magnesium ions can be greatly prolonged, that is, repairing of cartilage by synovial fluid progenitor cells is continuously promoted; on the other hand, the self-lubricating effect of the lipid-based super-lubricating hydrogel microspheres can reduce the secondary wear of the new cartilage; in addition, magnesium ions can remarkably promote expression of cartilage cells PRG4, so that the stable state of the cartilage cells can be maintained, and joint lubrication can be further enhanced.

The invention relates to the technical field of medical image navigation, in particular to a gout minimally invasive treatment multi-modal image navigation system which comprises a data acquisition module, a biomechanical fusion modeling module, a dynamic path planning module and a multi-physical field execution control module. The data acquisition module realizes synchronous acquisition of crystal-structure stress gradient, surface energy density and viscoelasticity parameters of the synovial fluid; the fusion modeling module generates a three-dimensional crystallization adhesion risk coefficient and fluid resistance prediction matrix based on a finite element and fluid-solid coupling algorithm; the path planning module dynamically calculates motion compensation and suction parameters in combination with real-time instrument poses, and outputs a six-degree-of-freedom navigation instruction set; and the execution control module drives the magnetic navigation puncture needle, the self-adaptive suction device and the laser ablation unit to realize cooperative execution of pose regulation and control, flow regulation and focus form switching. According to the method, gout crystallization accurate identification, path risk-avoiding navigation and targeted removal are realized, and the safety and the removal rate of minimally invasive intervention are remarkably improved.

This invention provides an exercise assistance device that assists the user in moving their hip joint in multiple directions, thereby improving the effects of increased synovial fluid, stretching, and muscle training. [Solution] The exercise assist device comprises a base that is placed on the floor, a seat on which the user sits, and legs connecting the base and the seat, the legs having at least one of a first connecting portion that rotatably connects the lower end to the base and a second connecting portion that rotatably connects the upper end to the seat.

A medical device includes a needle, a syringe, and a probe assembly respectively connected to a main body. The syringe may include a cavity in fluid communication with a bore through a shaft of the needle and is configured to draw a fluid into the cavity through the needle. The probe assembly may include a probe that is movable through the bore.

The invention provides a biochip for detecting a marker LTF in synovial fluid as well as a preparation method and application of the biochip. The biochip comprises a solid phase carrier and an immunodetection system, the solid-phase carrier comprises a plastic substrate and a water-soluble glue layer; the immunodetection system comprises a photonic crystal array formed by self-assembly on a plastic substrate, and a biological material chemically modified on the surface of the photonic crystal array, the biological material is used for targeted recognition of a target detection object; the biological material is selected from lactoferrin capture antibodies; the target detection object is lactoferrin. The biochip disclosed by the invention has the advantage of rapid detection, and the reaction time of the detection method disclosed by the invention can be shortened to 10 minutes as different from that of an ELISA (enzyme-linked immuno sorbent assay) method which needs 4 hours, so that the detection efficiency and the practical application value of the biochip are greatly improved.

The invention discloses a detection kit for detecting the content of calprotectin in synovial fluid. The detection kit comprises a detection kit shell and a calprotectin immunochromatography test strip, and the calprotectin immunochromatography test strip is arranged in the detection kit shell; the calprotectin immunochromatography test strip comprises a sample pad, a glass fiber combination pad, a coated nitrocellulose membrane and a water absorption pad which are bonded in sequence, an anti-calprotectin antibody marked by colloidal gold is embedded in the glass fiber combination pad and is used for being combined with calprotectin in a sample to be detected to form a compound; the anti-calprotectin monoclonal antibody is coated on a detection line of the nitrocellulose membrane, and the anti-mouse IgG antibody is coated on a quality control line of the nitrocellulose membrane; the colloidal gold labeled anti-calprotectin antibody is embedded in the glass fiber cushion layer, and the image recognition module is used for collecting a tested test paper image and calculating a relative gray value of a detection line and a quality control line, so that a calprotectin concentration interval is judged.

The invention discloses a butyl-glycine cross-linked sodium hyaluronate gel and a composition and a preparation method thereof. The cross-linked sodium hyaluronate gel is a gel mixture formed by swelling gel of cross-linked hyaluronic acid and salt thereof in a sodium chloride phosphate physiological buffer solution, wherein the gel of the cross-linked hyaluronic acid and the salt thereof is prepared by cross-linking the hyaluronic acid or the salt thereof with a cross-linking agent; wherein the D50 particle size distribution range of the gel mixture is 300-3000 [mu] m, so that the gel mixture can better simulate the physical characteristics of healthy joint synovial fluid and provide more effective lubricating and buffering effects under the condition of the same gel molecular weight and energy storage elastic modulus, thereby relieving joint friction and pain and improving the curative effect of cross-linked sodium hyaluronate maintained in vivo.

The invention belongs to the technical field of biological medicine, and relates to application of ABT-737 in preparation of anti-inflammatory drugs, in particular to application of ABT-737 in preparation of drugs for treating refractory rheumatoid arthritis. It is found for the first time that ABT-737 can induce apoptosis of inflammatory T cells derived from peripheral blood or synovial fluid of a patient suffering from the refractory rheumatoid arthritis, reduce the number of the inflammatory T cells and further inhibit occurrence and development of inflammation, and therefore ABT-737 has the prospect of being developed into drugs for treating the refractory rheumatoid arthritis and anti-inflammatory or immunomodulatory drugs.

The invention belongs to the technical field of biological medicines, and particularly relates to application of Venetoclax in preparation of an anti-inflammatory drug, in particular to a drug for treating rheumatoid arthritis (RA) with insufficient (MTX-IR) by using methotrexate. It is found for the first time that Venetoclax can induce apoptosis of inflammatory T cells of peripheral blood or synovial fluid of rheumatoid arthritis patients with insufficient curative effect on methotrexate, and occurrence and development of inflammation are inhibited by reducing the number of the inflammatory T cells, so that Venetoclax has the prospect of being developed into drugs for treating rheumatoid arthritis and anti-inflammatory and immunomodulatory drugs.

The invention relates to the technical field of veterinary drugs, and provides a medicament for preventing and treating chicken mycoplasma synoviae and a preparation method thereof.The medicament is prepared from, by weight, 40-50 parts of nanometer material modified doxycycline, 30-40 parts of glucose, 2-3 parts of sodium chloride, 1.5-2.5 parts of sodium dihydrogen phosphate, 5-8 parts of antioxidant, 1-2 parts of preservative and 0.5-1.5 parts of silicon dioxide. The medicament product disclosed by the invention is stable in quality, various indexes are not influenced, the doxycycline is modified so that the medicament product has a slow release effect, the bitter taste of the doxycycline is reduced, the compliance of chickens is improved, the stress reaction of the chickens is reduced, the bioavailability is high, the treatment effect on the mycoplasma synoviae of the chickens is good, and the medicament product has a better market value.

The invention provides a 3D synovial cartilage organ chip with a bionic structure and a preparation method and application thereof, and relates to the technical field of organ chip manufacturing. The organ chip comprises a main body; the main body comprises a top layer, a cartilage layer, a joint synovial fluid layer, a synovial membrane and an endothelial channel layer which are arranged in sequence; a cartilage cavity for accommodating articular cartilage cells is formed in the cartilage layer; a synovial fluid cavity used for containing joint synovial fluid is formed in the joint synovial fluid layer. A synovial membrane channel and an immune cell channel are arranged in the synovial membrane and endothelial channel layer in parallel; a permeation zone is arranged between the synovial membrane channel and the immune cell channel; a pressure cavity is formed in the top layer, and an elastic film is arranged on the portion, on one side of the cartilage cavity, of the pressure cavity. According to the scheme, mechanical stimulation is integrated into the organ chip, and in-vivo periodic compression during walking / activity of a human body can be reproduced, so that mechanical-biochemical coupling of a cartilage-synovial membrane-bone interface is simulated more truly, and the similarity of an in-vitro model is improved.

A medical device includes a needle, a syringe, and a probe assembly respectively connected to a main body. The syringe may include a cavity in fluid communication with a bore through a shaft of the needle and is configured to draw a fluid into the cavity through the needle. The probe assembly may include a probe that is movable through the bore.

A surgical system includes a surgical generator and at least one energy delivery device. The surgical generator includes at least one energy output stage configured to deliver energy, a controller configured to control the energy output, and sensor circuitry. The energy delivery device(s) is coupled to the surgical generator, configured for insertion into a synovial joint, and configured to supply energy through synovial fluid in the synovial joint. In a sensing mode, the sensor circuitry is configured to sense at least one electrical parameter of the energy and the controller is configured to determine a parameter of the synovial fluid based thereon. The controller is further configured, in a treatment mode, to control the energy based upon the at least one determined parameter of the synovial fluid to treat tissue of the synovial joint.

The present disclosure is directed to a kit and methods for using the same. The kit includes a plate including at least one well, wherein the well includes a silver nitrate and a catalyst. The method includes providing a sample of synovial fluid to a well of a plate, wherein the well includes a silver nitrate and a catalyst and determining a presence of monosodium urate (MSU) crystals, wherein the presence of MSU crystals indicates that gout is detected in the sample.

The present application discloses a lower limb strength testing device for the elderly, belonging to the technical field of lower limb strength testing. It includes a sliding table, a detection mechanism, and a rehabilitation training mechanism. The sliding table is installed on the bed body, and the detection mechanism is installed on the sliding table. The detection mechanism includes a fixed seat and a movable seat. First pressure sensors are respectively arranged on both sides of the fixed seat, and the movable seat is installed between the two first pressure sensors. The rehabilitation training mechanism includes a support rod, a first driving component, and a second driving component. A pedal is installed on the support rod and a second pressure sensor is provided. The present invention only requires the user to lie on the bed body to perform lower limb strength testing, improving the convenience of use and ensuring the safety of use. Through the rehabilitation training mechanism, it can promote the secretion of joint synovial fluid of the user, improve joint flexibility, help enhance and restore muscle strength, meet the user's needs for rehabilitation training, expand the scope of use, enrich the use functions, and have good economy.

A hip joint replacement system includes an insert configured to be disposed on an articular surface of a hip joint, a biocompatible fluid including a synthetic synovial fluid, a porous condyle configured to contain the biocompatible fluid and to be disposed on an opposing surface of the hip joint, and a sensor disposed along a top surface of the insert.

The invention relates to a bone joint injection as well as a preparation method and application thereof. The bone joint injection comprises dopamine modified hyaluronic acid, amino-polyethylene glycol and a dissolving solution. The amino-polyethylene glycol is introduced into the dopamine modified hyaluronic acid, so that the micro-crosslinking effect can be enhanced, the mechanical property of the bone joint injection is improved, and the problems of joint abrasion and the like caused by lack of bone joint synovial fluid are remarkably improved.