12 results about "Reactive oxygen radicals" patented technology

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

This invention relates to the field of thin film technology, specifically providing a polymer thin film and its manufacturing method, comprising the following raw materials in parts by weight: 48-52 parts of recycled polypropylene (rPP), 38-42 parts of polybutylene adipate-butylene terephthalate (PBAT), 7-9 parts of surface-aminated modified nanocellulose whiskers (CNC, diameter 20-30 nm), and 1.2-1.8 parts of bio-based interface stabilizer. This invention utilizes maleic anhydride grafted lignin to form a three-dimensional hydrogen bond network with rPP / PBAT. DSC measurements show a phase separation temperature difference ΔT = 35℃ and an interfacial peel strength of 13.2 N / cm. The synergistic effect of the epoxy-functionalized castor oil ring-opening reaction and the release of reactive oxygen free radicals from mesoporous zinc oxide (6-10 nm) increases the gel content to 72%. Hindered amine additives are released slowly through the mesoporous zinc oxide nanopores, blocking the PBAT ester hydrolysis chain reaction, resulting in a 60% reduction in the measured hydrolysis rate. A temperature path of 155℃→210℃→160℃ is used, with a melt viscosity fluctuation rate of ±2.5%, solving the problem of a narrow processing window caused by the heat sensitivity of PBAT.

The application discloses a kind of corona discharge ion wind auxiliary chemical mechanical polishing processing method for ceramic, comprising the following steps: step S1, ceramic workpiece is immersed in alkaline abrasive liquid;Step S2, ion wind is released using ion wind generating device, ceramic workpiece is in ion wind covered area, ion wind generating device is installed in the spindle support of grinding machine tool, ion wind generating device moves together with spindle, so that ion wind released by ion wind generating device is aligned with the processing area of ceramic workpiece in real time;Step S3, active oxygen free radicals contained in ion wind dissolve into alkaline abrasive liquid, and continuously occur chemical reaction with ceramic workpiece surface in processing process and produce soft layer, under the stable state of ion wind, ceramic workpiece surface is polished.The application provides a kind of corona discharge ion wind auxiliary chemical mechanical polishing processing method for ceramic, improves material removal efficiency, while improving surface quality and inhibiting surface damage, and regulates wettability.

The application belongs to the technical field of hematin quantitative detection, and specifically discloses application of methylene blue cyclopropyl formylated derivative as a chromogenic substrate for detecting hematin, and uses methylene blue cyclopropyl formylated derivative AMB as a chromogenic substrate for detecting hematin Hemin; compared with a classical substrate TMB, the methylene blue cyclopropyl formylated derivative AMB of the application has higher sensitivity in the detection of hematin Hemin; in addition, the amino protons of the methylene blue cyclopropyl formylated derivative AMB of the application are fully substituted by methyl, which inhibits the participation of active oxygen free radicals in oxidation, but is still sensitive to the oxidation pathway of ferric free radicals, has better selectivity compared with TMB, and the AMB system can effectively detect hematin Hemin in a serum sample. Therefore, it can be said that for the detection of hematin Hemin, AMB is a more excellent colorimetric substrate than TMB.

This invention belongs to the field of cosmetic composition technology, specifically relating to an essential oil composition with repairing and anti-aging effects and its application. The essential oil composition consists of carrot seed oil, white chamomile flower oil, and unsaponifiables from shea butter. This composition effectively promotes the release of endorphins from skin cells, helping to relieve skin stress; simultaneously, it significantly inhibits excessive cortisol secretion under stress, alleviating skin stress responses at their source. This composition exhibits excellent barrier repair capabilities, promoting keratinocyte migration and scratch healing, upregulating the expression of barrier-related genes, and effectively scavenging UV-induced reactive oxygen species, reducing oxidative damage. Furthermore, this composition significantly promotes the expression of type I and type III collagen, exerting repairing and anti-aging effects from multiple perspectives.

The application discloses a synergistic anti-oxidation ergothioneine composition and application thereof in anti-fatigue beverages. In the application, a multi-level anti-oxidation defense system is constructed by the combination of ergothioneine and pyrroloquinoline quinone, from free radical scavenging to cell energy metabolism to form a complete protection chain. Ergothioneine can directly capture and neutralize active oxygen free radicals in cells, protect cell membranes, proteins and DNA from oxidative damage, and reduce the generation of hydroxyl radicals by chelating metal ions. Pyrroloquinoline quinone can activate the mitochondrial biosynthesis pathway, improve the cell energy metabolism efficiency, and enhance the activity of the cell's own antioxidant enzyme system, thereby reducing the generation of free radicals from the root. The synergistic effect of the two can not only quickly remove the formed free radicals, but also enhance the cell's anti-oxidation repair capacity.

The application discloses antibacterial and antioxidative AgPt3 intermetallic compound nanoparticles and a preparation method and application thereof, and relates to the technical field of noble metal nanomaterials. The antibacterial and antioxidative AgPt3 intermetallic compound nanoparticles are prepared by using a chemical reduction method, and the specific method is as follows: soluble silver salt and platinum salt are dissolved in water and are ultrasonically treated to obtain a metal precursor solution. The metal precursor solution is dropped into an aqueous solution containing a stabilizer and a reducing agent, and continuous stirring reaction is carried out. The obtained suspension is subjected to centrifugation, washing and drying to obtain the antibacterial and antioxidative AgPt3 intermetallic compound nanoparticles. The Ag and Pt form an intermetallic compound structure, the chemical stability of the material is enhanced, and the potential cytotoxicity caused by rapid ion release is effectively reduced. The synthesized AgPt3 nanoparticles exhibit strong killing effect on gram-positive and gram-negative bacteria; meanwhile, the AgPt3 nanoparticles can effectively eliminate various active oxygen free radicals and relieve oxidative stress. The AgPt3 nanoparticles have wide application prospects in the fields of biomedicine, food packaging and cosmetics.

This utility model relates to the field of catering products technology and discloses a titanium enamel antibacterial cookware, including a tableware body. The tableware body has a titanium alloy base layer inside, and a sintered titanium enamel layer is provided on the inner surface of the titanium alloy base layer. Antibacterial particles are uniformly dispersed on the inner side of the sintered titanium enamel layer, and an outer ceramic layer is provided on the outer side of the titanium alloy base layer. The titanium alloy base layer provides a high-strength support skeleton, and the sintered titanium enamel layer on its surface forms a dense protective barrier. The antibacterial particles (nano-titanium dioxide and silver particles) embedded in this layer constitute the core antibacterial mechanism. When the tableware is exposed to natural light or artificial light, the antibacterial particles trigger a photocatalytic reaction, continuously releasing reactive oxygen free radicals and silver ions, directly destroying bacterial cell membranes and blocking DNA replication, achieving an ultra-high broad-spectrum antibacterial rate. This design breaks through the limitation of traditional coatings being easily worn off. The Mohs hardness of the sintered titanium enamel layer ensures that the antibacterial particles are firmly encapsulated. Even with long-term wear and tear, the inner particles can still slowly release antibacterial factors.

This invention provides a reduced single-atom nanomedicine, its preparation method, and its application, belonging to the field of nanobiomedicine technology. The single-atom nanomedicine prepared by this invention is a cerium single-atom-anchored phosphomolybdic acid nanocluster, namely Ce-POM. The preparation method includes using activated carbon as a substrate, adding a phosphomolybdic acid solution for loading, subsequently introducing cerium(III) acetylacetone hydrate for mixing and stirring, and finally calcining and reducing with hydrogen in a tubular furnace to obtain the Ce-POM single-atom nanomedicine. The Ce-POM nanomedicine of this invention possesses peroxidase-like and catalase-like activities. Through highly efficient multi-enzyme activity and charge migration, it promotes the consumption of reactive oxygen species (ROS), reduces cellular oxidative stress damage, inhibits ferroptosis, improves the microenvironment of neural tissue in cerebral hemorrhage, and promotes neural tissue repair. Simultaneously, the decrease in ROS levels further inhibits the activation of the intracellular immune signaling pathway cGAS-STING, regulates immune system function, protects neural cell repair, and achieves the ideal therapeutic effect for cerebral hemorrhage.

This invention discloses a method for promoting the production of short-chain fatty acids through anaerobic fermentation of waste sludge, relating to the field of solid waste treatment technology. The method includes the following steps: before anaerobic fermentation, biochar and persulfate are added to the waste sludge for pretreatment. This invention utilizes biochar to activate the SO4· ... ‑ ·OH and 1 O2 and other reactive oxygen species disrupt the structure of sludge cells, causing them to release large amounts of organic matter, increasing the rate of hydrolysis, and enhancing the metabolism of acid-producing microorganisms, thereby promoting the generation of high-quality recyclable short-chain fatty acids. This achieves the reduction, stabilization, and resource recovery of excess sludge, not only treating waste with waste but also avoiding the introduction of new pollutants. Compared with existing technologies, this invention has advantages such as low cost, short anaerobic digestion time, no secondary pollution, and ease of implementation. It solves the problems of large volume of excess sludge, high hazard, and difficulty in resource recovery.

The application discloses a five-element co-doped porous CoFeCuMnNi-LDH nanomaterial and a preparation method and application thereof, and relates to the technical field of functional nanomaterials. In the application, cobalt salt, iron salt, copper salt, manganese salt and nickel salt are prepared into a multi-element metal salt precursor solution according to a proportioning ratio, an alkaline solution of NaOH and Na2CO3 is compounded, a target material is prepared through water bath mixing, microwave-hydrothermal combined reaction, and combination of chitosan quaternary ammonium salt modification and freeze drying. The material has a two-dimensional layered porous structure, excellent photocatalytic and peroxidase-like activities, and can efficiently produce reactive oxygen free radicals. The material is synergistically bactericidal with the quaternary ammonium salt, has high efficiency, and has a simple, environment-friendly and easy industrialization preparation process.

The application discloses a kind of biomimetic enzyme catalytic membranes based on hydrogen bond donor / acceptor modification and its preparation and water treatment application, belong to catalytic membrane technical field.The hydrogen bond donor / acceptor modified biomimetic enzyme catalytic membrane of the application includes microfiltration membrane, including microfiltration base membrane, and biomimetic enzyme catalyst loaded on the surface of microfiltration base membrane;The biomimetic enzyme catalyst uses metal organic framework material MOFs as substrate, and amino acid rich in hydrogen bond donor / acceptor is loaded on the surface of the substrate.The hydrogen bond network formed by the application can accelerate the transmission of protons and electrons, enhance the affinity with hydrogen peroxide, and thus greatly improve the utilization rate of hydrogen peroxide and the steady-state concentration of active oxygen free radicals;At the same time, the constructed biomimetic enzyme-membrane reactor realizes the double coupling of membrane separation and enzyme catalysis, greatly improves the removal efficiency of new pollutants in water body.