89 results about "Reactive oxygen radicals" patented technology

The invention discloses a porous CoFe hydrotalcite nano material as well as a preparation method and application thereof, and relates to the field of nano materials. The porous CoFe hydrotalcite nano-material is of a porous layered double hydroxide nano-structure, and the aperture of the porous CoFe hydrotalcite nano-material ranges from 2 nm to 10 nm. The porous CoFe hydrotalcite nano material is prepared through a microwave hydrothermal synthesis method, the preparation method is simple, easy to operate and environmentally friendly, and industrial production can be achieved. The porous CoFe hydrotalcite nano material prepared by the method is stable in structure, has photocatalytic activity and peroxidase-like activity, can effectively catalyze and generate various reactive oxygen free radicals under the illumination condition, realizes efficient synergistic killing of bacteria, and has a good antibacterial effect.

The invention provides an application of a sunflower HaSnRK2 gene in regulating and controlling salt tolerance and drought tolerance of plants, and belongs to the technical field of plant genetic engineering. The invention provides an overexpression vector of a sunflower HaSnRK2 gene. The overexpression vector is applied to regulation and control of salt tolerance and drought tolerance of plants after genetic transformation is carried out on the plants by using a flower dipping method. Through overexpression of the sunflower HaSnRK2 gene, the salt stress tolerance and the drought stress tolerance of plants are remarkably enhanced, and damage caused by reactive oxygen free radicals induced by salt stress and drought stress can be effectively relieved.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of butynedioic acid. The preparation method of the butynedioic acid comprises the following steps that butynediol is oxidized into the butynedioic acid through pypocholoride and a catalyst, and the catalyst comprises carbon black and a metal compound loaded on the carbon black. According to the invention, butynediol is used as a raw material, and butynediol is oxidized by using pypocholoride and a catalyst to prepare butynedioic acid. Wherein butynediol is easy to obtain, and the raw material cost is low. In addition, the catalyst uses carbon black to immobilize a metal compound, conversion of pypocholoride into a large number of reactive oxygen free radicals can be accelerated, butynediol can be efficiently oxidized under the action of pypocholoride and the catalyst, and the whole synthesis route is safe and green, simple and feasible in process, low in equipment requirement, low in operation cost, free of secondary pollution and low in production cost.

The invention discloses a preparation method of graphene quantum dot cloud wool, and relates to the technical field of cloud wool production. According to the method, citric acid is used for assisting ultrasonic stripping of graphene, stripping of graphene in the three-dimensional direction is converted into shearing in the two-dimensional direction under the cavitation effect of ultrasonic, interaction between citric acid and graphene is promoted, then ball milling treatment is carried out, the obtained graphene quantum dots have the huge specific surface area and high surface activity, and the graphene quantum dots have the large specific surface area and the high surface activity. The antibacterial effect is achieved; then, nano-silver is compounded, the self-agglomeration effect of particles is reduced, the reducibility of the graphene quantum dots is enhanced, in the presence of oxygen molecules, a large number of reactive oxygen free radicals are generated, the antibacterial property is improved, hollow short fibers are prepared through coaxial spinning, the contact space between a matrix and air is enlarged, and then the antibacterial property is enhanced.

According to the nano-component gel for repairing and regenerating the infectious diabetes skin defects, the hyaluronic acid modified by the o-nitrobenzyl alcohol derivative and the nano-zinc oxide are subjected to in-situ cross-linking to form the hydrogel, reactive oxygen free radicals at the skin defects can be removed, and the skin defects can be repaired and regenerated. The expression of TNF-alpha of skin defect tissues is reduced, the expression of VEGF is improved at the same time, and collagenous fiber deposition at the diabetic skin defect repair position is promoted, so that rapid repair of infectious diabetic skin defects is promoted, and the problem that the infectious diabetic skin defects are difficult to repair is effectively solved.

The application discloses a preparation method of graphene quantum dot cloud wool, and relates to the technical field of cloud wool production. The graphene is peeled off by using citric acid assisted ultrasonic stripping, the ultrasonic cavitation effect is used to convert the three-dimensional peeling of the graphene into two-dimensional shearing, and the interaction between the citric acid and the graphene is promoted, then ball milling treatment is carried out, the obtained graphene quantum dots have a large specific surface area and high surface activity, and the antibacterial effect is realized; then, the silver nanoparticles are compounded, which not only reduces the particle self-agglomeration effect, but also enhances the reducibility of the graphene quantum dots, a large number of active oxygen free radicals are generated in the presence of oxygen molecules, the antibacterial property is improved, and the hollow short fibers are prepared through coaxial spinning, the contact space of the matrix and air is increased, and the antibacterial property is further enhanced.

The present application provides an indole derivative and a preparation method and application thereof. The preparation method comprises the following steps: dissolving copper acetate and triethylamine in isopropyl alcohol, stirring until completely dissolved to obtain a reaction medium; adding 5-bromo indigo and indole into the reaction medium, fully stirring at room temperature until the reaction is completely converted; removing the reaction solvent by distillation to obtain a crude product, purifying and recrystallizing to obtain a high-purity solid powder of the indole derivative. The indole derivative has a significant inhibitory effect on tyrosinase, melanin production and transfer; has high antioxidant capacity for scavenging intracellular active oxygen free radicals; through the mechanisms of affecting the membrane potential of mitochondria, activating the related apoptosis signaling pathway and promoting the expression of apoptosis proteins, etc., the A549 cell is prompted to enter the apoptosis program, thereby providing a new potential strategy and research direction for the apoptosis regulation of tumor cells, and having important research value and application prospect.

This invention discloses a method for preparing cerium phytate complexes and their biological applications. A cerium ion aqueous solution is added to a phytic acid aqueous solution under stirring, and stirring continues until precipitation is complete. The mixture is then washed with ultrapure water until the washing solution is neutral, filtered, and dried to obtain a cerium phytate complex with a porous nanostructure. This invention utilizes a method for preparing cerium phytate complexes with the above-described structure and their biological applications, without using organic solvents, making the synthesis process safe and environmentally friendly. Phytic acid, as a ligand molecule constituting cerium phytate, has six phosphate groups, which can efficiently coordinate with cerium ions to form cerium phytate materials, exhibiting good thermal stability and ultraviolet absorption. The cerium phytate nanoparticles formed by the coordination of phytic acid and cerium ions carry a large amount of Ce. 3+ This is the basis for the antioxidant activity of cerium phytate. At the same time, the numerous pores inside the material effectively promote the adsorption of reactive oxygen free radicals, giving it highly efficient antioxidant properties, which can be applied to the treatment of various diseases related to reactive oxygen species.

Modified polycaprolactone, zinc oxide and DMF are mixed to prepare a spinning solution, then the spinning solution is subjected to electrostatic spinning, drying and cutting, the tourniquet is prepared, modified polycaprolactone contains a quaternary ammonium salt structure, quaternary ammonium salt can adsorb bacteria with negative electricity through positive ions of the quaternary ammonium salt, and the antibacterial function is achieved. According to the tourniquet disclosed by the invention, zinc oxide is added into modified polycaprolactone, a hydrophobic group is inserted into a lipoid layer of a cell membrane, so that bacterial envelope dissolution and content release are caused, and further bacterial death is caused, zinc oxide can generate reactive oxygen free radicals when the tourniquet is illuminated, and further the bacterial cell membrane is damaged, so that the tourniquet has a very good antibacterial effect; according to the present invention, the cyclodextrin as the sacrificial conformation is embedded in the molecular skeleton, the conformation of the cyclodextrin is changed when the material is subjected to the external force so as to consume the energy, and the hyperbranched distribution of the polysiloxane chain segment and the polycaprolactone substantially improves the mechanical property of the material so as to improve the durability of the tourniquet;

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

The application discloses a use of a solute carrier family 25A33 gene in preparation of a medicament for treating presbycusis, and the use is achieved by enhancing SLC25A33 expression on an endolymphatic vascular stripe, by maintaining mitochondrial function stability of pericyte cells around the vascular stripe, by reducing active oxygen free radical (ROS) generation, and by blocking TGFbeta / SMAD pathway-mediated pericyte differentiation, so as to protect the integrity of the blood labyrinth barrier. Animal experiments show that overexpression of SLC25A33 can significantly reduce the hearing threshold of a presbycusis model mouse, protect the structure of the blood labyrinth barrier, and improve the expression of tight junction proteins, and the SLC25A33 gene has the potential to treat presbycusis.

The invention provides a swim bladder-based bioactive patch for rotator cuff tendon repair and a preparation method thereof, and relates to the technical field of biological materials.The swim bladder-based bioactive patch is composed of a swim bladder substrate and a metal-phenol toughening network component, has good tensile strength and biological activity and can be used for repairing rotator cuff tendons. The compound can support cell adhesion and proliferation, stimulate differentiation and phenotype maintenance of various cells derived from tendon-bone tissue, and is expected to be used for repairing rotator cuff tendon injury and promoting tendon-bone healing. Besides, the invention provides a preparation method of the swim bladder-based rotator cuff patch, a special microstructure of directionally arranged nano-matrix fibers is reserved, and a metal-phenol network further plays roles in toughening the patch and enhancing the biological activity of the material. Particularly, the metal-network has an active oxygen free radical response function, excessive free radicals at the shoulder joint part can be removed, and metal ions are released, so that the patch has the effects of resisting bacteria, resisting inflammation, resisting oxidation and improving healing.

The invention discloses air flotation separation and carbon neutralization wastewater pretreatment integrated equipment, which relates to the technical field of wastewater treatment and comprises a buffer adjusting unit and a catalytic reaction unit which are communicated along the flow direction of wastewater. Through the synergistic effect of integrated buffer adjustment, two-stage air floatation and photocatalysis, the problem that nanoscale colloids are difficult to capture in a traditional air floatation process is effectively solved while the colloid redispersion phenomenon caused by wastewater pH fluctuation is overcome. Specifically, an acid-base environment of wastewater is stabilized through a buffer mechanism of an organic acid component, abnormal changes of charges on the surface of colloid are inhibited, full-scale capture of micron-scale suspended particles and nano-scale colloid is realized by combining dual effects of micron-scale bubble adsorption and reactive oxygen free radicals generated by electrolysis, and the colloid is deeply mineralized through photocatalysis, so that the adsorption efficiency of the colloid is improved. The colloid is effectively intercepted after being oxidized and destabilized, so that the risk that the colloid is re-dispersed due to fluctuation of environmental conditions in a subsequent process is avoided, and the interception effect of the nanoscale colloid in a wastewater pretreatment process is improved.

The invention relates to the technical field of solar cells, in particular to a solar cell, a preparation method thereof and a photovoltaic module, and the preparation method comprises the steps: sequentially forming a composite layer and a hole transport layer on a bottom cell; forming a PbI2 skeleton layer on the hole transport layer, and coating the PbI2 skeleton layer with a cation wet film to prepare a perovskite light absorption layer; wherein the cationic wet film comprises an anthocyanin antioxidant and a cationic material. According to the preparation method, an anthocyanin antioxidant is introduced into cations to inhibit cation deprotonation and iodide ion oxidation processes, defects formed in the perovskite light absorption layer are reduced, and the film forming quality of the perovskite light absorption layer is improved; and meanwhile, active oxygen free radicals on the surface of the perovskite light absorption layer can be removed, and the problem that the perovskite light absorption layer is easy to accelerate degradation due to water and oxygen in the air is solved, so that the efficiency and the stability of the prepared solar cell are improved.

This invention discloses a near-infrared light-responsive porous membrane, its preparation method, and its applications, relating to the field of dressing technology. The near-infrared light-responsive porous membrane is composed of polyurethane, PDA@ZnO nanoparticles, and the antibacterial agent QCS. Under near-infrared light excitation, this near-infrared light-responsive porous membrane can generate reactive oxygen free radicals and heat, and release biofunctional zinc ions. Addressing the clinical challenges of chronic wounds, such as their susceptibility to infection and slow healing, this invention provides a new approach to improving the clinical treatment of chronic wounds by using a PDA@ZnO / QCS / TPU porous membrane that achieves highly efficient and precise sterilization under the synergistic effect of specific wavelengths of light, thereby preventing wound infection and promoting wound healing.

The invention discloses a porous hydrated calcium silicate material, a dry powder coating prepared from the porous hydrated calcium silicate material and application of the porous hydrated calcium silicate material. The preparation method comprises the following steps: taking tannic acid, carbon nanotubes and hydrated calcium silicate as main raw materials, preparing a porous hydrated calcium silicate material with an active oxygen free radical capturing function through a specific process, and stirring and mixing the porous hydrated calcium silicate material with various conventional dry powder coatings to prepare the building interior wall dry powder coating with the active oxygen free radical capturing function. The prepared building interior wall dry powder coating has good active oxygen free radical capturing capacity, can effectively purify indoor air and remarkably improve the indoor environment quality, and has certain application prospects in the field of building materials.

The invention discloses a CoS2 (at) TCPP-Co nano composite material as well as a preparation method and application thereof, and relates to the technical field of rapid detection of nano enzyme materials and efficient degradation of fungaltoxin. The preparation method of the CoS2 (at) TCPP-Co nano composite material comprises the following steps: dissolving cobalt nitrate and sodium thiosulfate in water, adding ethylene glycol and ethanol, stirring and heating to react, centrifuging, washing and drying a solid to obtain CoS2. The preparation method comprises the following steps: dissolving tetra (4-carboxyl phenyl) porphin and polyvinylpyrrolidone in N, N-dimethylformamide and absolute ethyl alcohol, uniformly mixing, adding CoS2, carrying out a constant-temperature reaction, and finally centrifuging, washing and drying to obtain the CoS2 atTCPP-Co nano composite material. The composite material shows excellent peroxidase-like activity, and can be coupled to a ligand to realize rapid quantitative detection of AFB1. In addition, reactive oxygen free radicals generated by the CoS2 (at) TCPP-Co in the catalytic reaction can efficiently destroy the molecular structure of AFB1, so that effective degradation of the toxin is realized.

The present application provides a polymyxin prodrug compound with the structure shown in formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof. The polymyxin prodrug compound of the present application can effectively reduce the biological toxicity of polymyxin, selectively activate in bacterial infected tissues, achieve bacterial killing in infected sites, improve the bioavailability of polymyxin, achieve sustainable development and utilization of classic antibiotics, expand the scope of future clinical application of polymyxin, and has a broad clinical application prospect.

The invention belongs to the field of biological materials, and particularly discloses a multi-component microcapsule with multiple ultrasonic responses as well as a preparation method and application of the multi-component microcapsule with the multiple ultrasonic responses, and a hydrogel microcapsule with structural and functional design is prepared through a microfluidic double-emulsion technology on the basis of light-cured methacrylic anhydride gelatin hydrogel and liquid decafluoropentane. According to the prepared multi-ultrasonic-responsive multi-component microcapsule, ultrasonic-responsive oxygen release and controllable generation of reactive oxygen free radicals are realized on the basis of curcumin loaded in methacrylic anhydride gelatin and oxygen dissolved in decafluoropentane; the released oxygen provides an oxygen raw material for sonodynamic therapy while relieving a hypoxic environment in an articular cavity, so that generation of reactive oxygen free radicals is enhanced, apoptosis of pathological synovial fibroblasts is induced, and synovial proliferation in the pathological articular cavity is inhibited.

The invention relates to a method for detecting pesticide based on a ferriporphyrin modified covalent organic framework nano-enzyme sensing array. According to the invention, ferriporphyrin molecules are loaded on a porous and ordered COFs skeleton, so that excellent peroxidase simulated catalytic activity is realized, H2O2 can be catalyzed to be decomposed to generate reactive oxygen free radicals, and TMB, OPD and ABTS chromogenic reactions are catalyzed. Based on the performance, a three-channel colorimetric sensing array is constructed to detect and distinguish various pesticides such as malathion, profenofos, chlorpyrifos, acephate and dimethoate, and the detection limit is as low as 0.341 nM. After different pesticides are adsorbed to active sites, catalytic reaction can be remarkably inhibited, and specific colorimetric fingerprint signals are generated. Colorimetric data is further combined with a machine learning algorithm, high-accuracy classification and recognition of single pesticides and mixtures thereof are achieved by means of a multilayer sensor, a support vector machine, a random forest and other models, the classification accuracy of an MLP model reaches 90%, ROC curve AUC exceeds 0.97, and the reliability of the detection method is proved.

The invention discloses a method for generating active oxygen free radicals based on calcium fluoride and application of the active oxygen free radicals. The method comprises the following steps: adding calcium fluoride into water, mixing and reacting to generate active oxygen free radicals OH and O < 2->; according to the principle of generating the reactive oxygen free radicals, calcium fluoride and an aqueous solution are adopted to form a solid-liquid interface, interface contact is promoted through vortex or ultrasonic waves, water molecules and hydroxyl ions are induced to lose electrons and generate OH through the contact electrification effect, and CaF2 captures the electrons to form CaF2 with negative electricity; then, O2 obtains electrons from CaF2, and O2 <-> is generated; the method can be used in the fields of environmental pollutant degradation and drug preparation. The function and mechanism of the CaF2 for catalyzing H2O and O2 to generate OH and O2-reactive oxygen free radicals are found for the first time, new application of the CaF2 is widened, an important scientific basis is provided for developing a novel catalysis strategy, and the CaF2 has important theoretical and application values.

The invention discloses an anti-aging ganoderma lucidum polysaccharide-milk composition and a preparation method and application thereof.The preparation method includes the steps that ganoderma lucidum sporocarp serves as a raw material, after superfine pretreatment is conducted, ganoderma lucidum polysaccharide is extracted in a free radical mediation mode, the polysaccharide yield is effectively increased, and the activity of the polysaccharide is effectively improved; and then active oxygen free radicals (. OH) and active nitrogen free radicals (DPPH) are respectively used as indexes to preferably select the ganoderma lucidum polysaccharide-milk composition with the optimal synergistic interaction ratio, so that the antioxidant activity of the ganoderma lucidum polysaccharide is improved. The ganoderma lucidum polysaccharide-milk composition preferably selected by the method disclosed by the invention not only has the nutritional values of polysaccharide and milk, but also synergistically enhances free radical scavenging, oxidative stress resistance and aging resistance, so that high-quality utilization of ganoderma lucidum and milk is realized.

The invention relates to the field of leather, in particular to oxidation-aging-resistant anti-cracking leather and a preparation method thereof. The method is used for solving the problems that existing leather is extremely prone to oxidation aging and cracks are generated. According to the leather, the phenolic hydroxyl isoquinoline, the benzophenone p-phenylenediamine and the modified polyurethane emulsion are used as coatings, and phenolic hydroxyl groups in phenolic hydroxyl isoquinoline molecules have good hydrogen atom transfer capacity and are combined with reactive oxygen free radicals generated in the leather oxidation process; benzophenone-based p-phenylenediamine has good ultraviolet absorption capacity and anti-aging capacity, a cross-linked network exists in the modified polyurethane emulsion, so that the anti-cracking performance of leather is improved, and the surface of the leather is coated with the modified polyurethane emulsion, so that the finally prepared leather material has excellent oxidation aging resistance and anti-cracking characteristics; and the durability and the use comfort of the product are improved.

The invention provides a metal organic framework for removing reactive oxygen free radicals in cigarette smoke as well as a preparation method and application of the metal organic framework. The metal organic framework comprises a three-dimensional porous organic framework formed by coordination assembly of organic ligands and metal ions, the organic ligand comprises any one of 2-methylimidazole, 1-methylimidazole and 2-nitroimidazole; the organic ligand comprises any one of 2-methylimidazole, 1-methylimidazole and 2-nitroimidazole; the metal ions comprise cerium ions and manganese ions; the molar ratio of the organic ligand to the metal ions is (20-30): (80-95); the molar ratio of the cerium ions to the manganese ions is (35-43): (45-52). In the metal organic framework provided by the invention, an organic ligand is used as a basic framework, metal ions are used as connecting nodes, and the formed nano structure has activity similar to catalase and superoxide dismutase, is high in thermal stability and large in specific surface area, can effectively catalyze and remove reactive oxygen free radicals in cigarette smoke, and can be used for preparing cigarette smoke. The harm of cigarette smoke to a human body is reduced.

The application belongs to the technical field of antibacterial infection materials, and particularly relates to preparation and application of a biomimetic mineralization nanoparticle. x S y / AZM, which is obtained by fixing glucose oxidase (GOx) in FexSy nanoparticles hybridized with azithromycin (AZM) through a biomimetic mineralization strategy, and the nanoparticle GOx@Fe x S y / AZM serves as a therapeutic drug to catalyze a large amount of active oxygen free radicals (ROS) to improve inflammatory response in order to rapidly kill infectious microorganisms in the early stage of bacterial infection of a wound surface; and in the subsequent healing period, H2S released by the material and AZM will jointly promote the polarization of macrophages to M2 macrophages of a repair type to effectively mediate the tissue repair after a high inflammatory response, so that the ordered treatment of a high blood sugar infection wound surface is achieved.

The invention relates to the field of cosmetics, in particular to sunscreen powder slurry, a preparation method thereof and a sunscreen cosmetic. The sunscreen powder slurry comprises a yeast melanin solution, sunscreen powder, a dispersing agent, an emulsifying agent and grease; the proportion of the yeast melanin solution in the sunscreen powder syrup is 0.00001%-10%; the sunscreen powder accounts for more than 50% of the sunscreen powder syrup; the sunscreen powder comprises any one of unmodified titanium dioxide, modified titanium dioxide, unmodified zinc oxide or modified zinc oxide; the average particle size of the sunscreen powder in the sunscreen powder slurry is 100-380 nm. The melanin has the capability of scavenging free radicals, and can be used as an additional defense line to quench reactive oxygen free radicals generated after the skin is irradiated by ultraviolet rays, so that secondary light protection is provided, and the light aging damage of the skin is relieved. The particle size of the particles is far smaller than the wavelength of visible light, and scattering of the visible light is weakened, so that the false white feeling is remarkably relieved, and the skin feeling is more natural and transparent.

The present invention provides a method for the hydroformylation of allyl acetate that can avoid runaway reaction and equipment overheating. Allyl acetate can undergo hydroformylation with a mixture of hydrogen and carbon monoxide in the presence of a complex catalyst. However, the heat of reaction of the allyl acetate hydroformylation reaction is as high as 1406 J / g. AAC The heat of reaction of the secondary decomposition reaction of allyl acetate is as high as 1167 J / g AAC If the reaction system's heat transfer rate is slower than its heat release rate or a secondary decomposition reaction of allyl acetate occurs, the system temperature may rise above 600°C, causing the reaction equipment to overheat and then overpressure. The present invention adds a suitable organic peroxide to the allyl acetate hydroformylation reaction system. The organic peroxide decomposes at high temperatures when abnormal operating conditions occur, generating active oxygen radicals that promptly destroy the complex catalyst structure and poison the catalyst. This prevents uncontrolled heat release from the allyl acetate hydroformylation reaction, which could lead to equipment overheating or the initiation of a secondary decomposition reaction of allyl acetate.

The present invention relates to a VOCs treatment device and method based on room-temperature ozone catalytic oxidation and micro-nano bubbles. The device comprises a pretreatment zone, a catalytic reaction zone and a deep purification zone which are sequentially connected. The pretreatment zone is provided for removing more than 99% of particulate matter in VOCs waste gas by a large-volume cyclone dust collector. At the same time, ozone generated by a first ozone decomposition module is fully mixed with the VOCs waste gas to decompose the VOCs waste gas. The catalytic reaction is then provided to deeply oxidize and decompose VOCs at room temperature, and to decompose cyclic compounds by ring-opening oxidation. The deep purification zone is then provided for convection and uniform mixing of the VOCs waste gas and the sprayed micro-nano bubble solution from bottom to top. At the same time, the rupture of the micro-nano bubbles locally generates a high-temperature, high-pressure subcritical state and produces a large number of active oxygen free radicals, thereby enhancing the degradation ability of the spraying process. Compared with existing commonly used technologies, the present invention has lower operating costs and energy consumption and stronger operating stability.

This invention provides a method for treating xanthate-based mineral processing wastewater using natural minerals, belonging to the field of water treatment technology. The method includes: adding pyrite powder to the xanthate-based mineral processing wastewater for activation treatment, converting xanthate groups into dixanthate groups, resulting in activated mineral processing wastewater; passing the activated wastewater through a galvanic cell filter layer while aeration is introduced, obtaining a first solution; and passing the first solution sequentially through a metal purification filter layer and a control filter layer to obtain mineral processing return water. The galvanic cell filter layer comprises pyrite, pyrolusite, and graphite. Through the coupling effect of pyrite and pyrolusite, oxygen in the air is activated into reactive oxygen free radicals and / or ozone, which oxidize and degrade the xanthate-based organic matter in the mineral processing wastewater.

The invention relates to a combined treatment method for tumors in a diabetic state, and belongs to the field of biological medicines. According to the method, photodynamic therapy is carried out by adopting photosensitive composite nanoparticles (UCS NPs) constructed by upconversion nanoparticles-silicon dioxide-chlorin e6, and an inhibitor for inducing a metastasis pathway by aiming at tumor-related fibroblasts is used in a combined manner. Active oxygen free radicals are generated through photodynamic therapy to kill tumor cells, and an inhibitor is combined to block a metastasis pathway, so that tumor growth and metastasis are synergistically inhibited in a diabetes mellitus high-glucose microenvironment. The problem that the curative effect of a single therapy is limited under the complex state of diabetes mellitus is solved, and the pharmaceutical composition has the advantages of strong synergistic effect, high targeting property, good biological safety and the like, is suitable for treating diabetes mellitus complicated with melanoma, and has a wide clinical application prospect.