The present disclosure provides for a method of forming, producing or manufacturing functionalized and soluble 
nanomaterials, most specifically carbon nanotubes on a substrate, which can be used in the production or manufacture of 
biofuel cells. One embodiment provides for the 
coupling of 
biofuel cells with a nanomaterial, wherein the nanomaterial supports catalytic enzymes. Another embodiment provides for a 
biofuel cell which uses enzymes immobilized on 
nanomaterials as electrodes. Another embodiment provides for the construction of a biofuel 
cell, wherein the application of a 
microwave process, and / or an electrochemical technique, is used to develop a biofuel 
cell having nanomaterial / 
enzyme-based electrodes on a substrate. Another embodiment provides for a composite of nanomaterial grown on a substrate, coupled to tethered or bonded enzymes, which makes it possible to fabricate direct 
electron transfer electrodes. Another embodiment provides for an 
implanted device. Another embodiment provides for a biofuel cell that can also function as a 
biosensor. A method for producing a nanomaterial-substrate 
system is also disclosed.