58 results about "Benzothiazole" patented technology

This invention discloses an analytical method for benzothiazole contaminants, comprising the following steps: detection by high performance liquid chromatography (HPLC), with the following chromatographic conditions: a phenylhexyl column as the stationary phase, mobile phase A being water, mobile phase B being acetonitrile, and gradient elution; wherein the benzothiazole contaminants are at least one of 2-aminobenzothiazole, 2-hydroxybenzothiazole, benzothiazole, 2-methylbenzothiazole, 2-mercaptobenzothiazole, 2,5-dimethylbenzothiazole, 2-cyanobenzothiazole, ethyl 2-carboxylate benzothiazole, 2-chlorobenzothiazole, 2-bromobenzothiazole, 2-methylthiobenzothiazole, phenylthiocyanate, N-tert-butyl-2-benzothiazole sulfenamide, 2-(2-hydroxyphenyl)-benzothiazole, N-cyclohexyl-2-benzothiazole sulfinamide, dibenzothiazole disulfide, and N,N-dicyclohexyl-2-benzothiazole sulfonamide.

An attractant for Telenomus remus Nixon to control Spodoptera litura Fabricicus is provided. The attractant includes a solvent and at least one of the following components: 1,3-dichlorobenzene, benzothiazole, and octane. The attractant can effectively attract Telenomus remus Nixon to parasitize Spodoptera litura Fabricius eggs, such that the growth of a pest quantity is inhibited and the pest population gradually dies out, which achieves the purpose of pest control. The attractant is a green, non-toxic, and pollution-free attraction substance. Therefore, the attractant can solve a series of problems such as pesticide residues, environmental pollution, and food safety caused by chemical control, and is of great significance for the green control of Spodoptera litura Fabricius.

The application relates to a salt type of a new cell cycle regulatory kinase inhibitor and a crystal form and a preparation method thereof, and relates to a succinate salt of a compound (6-((4-(2-(diethylamino)benzo[d]thiazol-6-yl)-5-fluoropyrimidin-2-yl)amino)pyridin-3-yl)(4-isopropylpiperazin-1-yl)methanone and a crystal form thereof, wherein two crystal forms II and III of the succinate salt are good in stability, high in solubility, and the preparation method is simple and suitable for industrial production.

The application provides a preparation method of an oxygen-containing carotenoid, in particular a preparation method of canthaxanthin (I-a) or astaxanthin (I-b), and the preparation method comprises the following steps: (1) C15-alcohol (II) is reacted with 2-mercaptobenzothiazole (MBT) to prepare C15-benzothiazole sulfide (III), and the C15-benzothiazole sulfide (III) is further oxidized to prepare C15-benzothiazole sulfone (IV); (2) the C15-benzothiazole sulfone (IV) is coupled with C10-dialdehyde (V) to prepare the target product: canthaxanthin (I-a) or astaxanthin (I-b); the method has low raw material cost, avoids the use of phosphorus salt in the traditional synthesis route, and the by-product 2-hydroxybenzothiazole is an important intermediate for synthesizing the herbicide thiobencarb, and also has economic benefits; and the method provides an efficient, economical and environmentally-friendly solution for large-scale clean production of canthaxanthin and astaxanthin.

This invention discloses a nopinel-based bifunctional fluorescent probe capable of simultaneously detecting hypochlorous acid and viscosity, along with its preparation method and applications. The probe is 2-(2-(5-(4-(3,3-dimethyl-1,2,3,4-tetrahydro-2,4-geomylidene-acridin-9-yl)phenyl)furan-2-yl)vinyl)-6-methoxy-3-methylbenzothiazolium iodide, abbreviated as TA-PFV-TI. This probe can specifically detect the viscosity and hypochlorous acid of a solution. Under 365 nm ultraviolet light irradiation, the probe's orange fluorescence gradually intensifies with increasing solution viscosity. The linear detection range for viscosity is 1.28 cP–1411.98 cP, with a response time within 1 second and a detection limit of 1.00 cP. Upon addition of hypochlorous acid to the probe solution, its fluorescence color changes from orange to bright blue. The linear detection range for hypochlorous acid is 0–200 μM, with a response time of 5 min and a detection limit of 2 nM. The applicable pH range is 5–9. This probe, as a bifunctional fluorescent probe capable of simultaneously detecting hypochlorous acid and viscosity, exhibits numerous advantages such as good selectivity, high sensitivity, and wide applicability, demonstrating promising application prospects.

The present invention relates to polymorphs of a protein kinase Mek inhibitor benzothiazole compound, processes for their preparation, and their medical use.

The present application provides a kind of benzothiazole amino acid ester derivative and its preparation method and purposes, the structural formula of the benzothiazole amino acid ester derivative is as shown in formula I, formula II or formula III. Wherein, R1 It is selected from H atom or the linear or branched alkyl of carbon atom number 8~20, R2 It is selected from H,‑CH(CH3)2,‑(CH2) n COOR1 Wherein n=1‑6, benzothiazole amino acid ester derivative of the present application has significantly antiwear, friction reducing and anti-rust performance, while also having excellent thermal stability.

This application relates to the field of medicinal chemistry, specifically disclosing an antitumor molecular gel compound and its preparation method. It is prepared from the following raw materials: phthalic anhydride or its substituted derivative, a 2-amino-6-substituted benzothiazole derivative, a condensing agent, an organic base, and a polar aprotic solvent. The preparation method is as follows: S1, dissolving the 2-amino-6-substituted benzothiazole derivative and the organic base in a solvent; S2, dissolving the phthalic anhydride or its substituted derivative in the solvent and adding it dropwise to a first mixture to obtain a second mixture; S3, adding the condensing agent to the second mixture; S4, quenching the reaction solution in ice water and extracting with ethyl acetate; S5, separating and purifying the crude product by column chromatography. The compound of this application can be used to develop novel antitumor drugs that target and degrade tumor-related proteins, possessing advantages such as molecular conformational stability, optimized physicochemical properties, hydrophobicity regulation, and enhanced binding affinity.

The application relates to a preparation method and application of a 2-acyl benzothiazole compound, which comprises the following steps: placing sulfur ylide in a sealed tube, adding a solvent to dissolve, and obtaining a first reaction system; adding nitrosobenzene into the first reaction system, stirring at a certain temperature for a certain time, and obtaining a second reaction system; adding sodium hydrosulfide, dimethyl sulfoxide, a metal salt, potassium persulfate and an alkali into the second reaction system, heating and stirring in the sealed tube to react, and obtaining a third reaction system; and carrying out post-treatment on the third reaction system to obtain the 2-acyl benzothiazole compound.The application has the advantages that the reaction condition is mild, the price of the sodium hydrosulfide sulfur source is low, and the reaction yield is high; the substrate applicability range is wide, various substrate structures can tolerate the reaction condition, and the 2-acyl benzothiazole derivative with diversified structures can be rapidly prepared.

The embodiment of the application discloses a method for treating microplastics and benzothiazole pollutants by electric stimulation and anaerobic microorganisms, relates to the technical field of environmental pollution treatment, and can effectively improve the treatment effect and efficiency of pollutants. The method comprises the following steps: arranging an anode and a cathode in a treatment medium containing microplastics and benzothiazole pollutants at a preset interval, wherein the treatment medium also contains anaerobic microorganisms; adding an electrolyte to the treatment medium and adjusting the electrolyte to a preset conductivity; connecting the anode and the cathode to a direct current power supply and applying a preset voltage to the treatment medium, and electrically stimulating the treatment medium at a preset temperature for a preset time. The application is suitable for pollution treatment scenes.

The application belongs to the technical field of paint preparation, and provides polyester resin powder paint with high salt mist corrosion resistance and a preparation method thereof.The powder paint is composed of a carboxyl functional polyester resin, a hydroxyalkylamide curing agent and / or trisglycidyl isocyanurate to form a film forming system, and is matched with titanium dioxide, inorganic fillers, acrylate leveling agent, benzoin and wax powder;quaternary ammonium poly-p-vinyl pyridine microgel is introduced into the paint, and double-particle-size microcapsules are added;the microcapsule core layer contains hydroxyl-terminated polydimethylsiloxane, mercaptobenzothiazole corrosion inhibitor components, polycarbodiimide and phthalate plasticizer, the shell layer is a polyurea inner shell and a polydopamine outer shell and contains a disulfide bond structure, an epoxy silane hydrolysis and condensation layer is arranged on the outer layer and loads the microgel.

The application discloses an additive for preparing high-strength extremely thin lithium battery copper foil under high current density and a production process, and belongs to the technical field of electrolytic copper foil. The additive is prepared by compounding collagen peptide, polydithiodipropyl sulfone sodium, polyethylene glycol-6000, 3-(benzo thiazole-2-methyl) propane sulfonic acid sodium, 2-methyl benzothiazole and hydrochloric acid according to specific contents. The production process comprises the following steps: preparing high-cleanliness copper sulfate electrolyte, mixing the additive with the electrolyte, mixing the additive with the electrolyte under 7000-7500 A / m 2 Electrodeposition foil under high current density. The application uses collagen peptide to replace traditional gelatin, cooperates with sulfur-containing additives and hydrochloric acid, and can significantly improve the tensile strength of copper foil, inhibit apparent defects such as copper powder and burrs, reduce warping and roughness, and can stably produce 4.5-6 mu m high-strength extremely thin lithium battery copper foil, which is suitable for the high energy density demand of power batteries.

This invention discloses a class of arylthiobenzothiazole compounds, their preparation methods, and applications. A class of arylthiobenzothiazole compounds, characterized in that they have a structural formula of one of formulas (1) to (2): where R... 1 Selected from one of -H, -Me, -OMe, -Cl, -Br, R 2 The compounds are selected from one of -H, -Me, -OMe, -t-Bu, -Cl, and -Br. This invention synthesizes a series of arylthiobenzothiazole compounds, and its synthesis method has the advantages of readily available raw materials, simple operation, mild reaction conditions, and wide substrate adaptability, and has good application prospects in the synthesis and research of optoelectronic materials and antiviral drugs.

Compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1) are provided.

This invention provides a two-site benzothiazole fluorescent probe, its preparation method, and its application, belonging to the field of organic synthesis technology. This invention provides a two-site benzothiazole fluorescent probe, constructed by modifying the benzothiophene fluorophore. This two-site benzothiazole fluorescent probe can chemically react with H₂O₂ and hypochlorite ions separately under the same detection conditions to generate different fluorescent substances, achieving the distinguishing detection of H₂O₂ and hypochlorite ions under the same excitation. It can simultaneously detect H₂O₂ and hypochlorite ions, exhibiting advantages such as high detection sensitivity, good selectivity, and high discrimination, and has good application prospects.

The application discloses a kind of corrosion-resistant magnesium alloy material and preparation method thereof, it is related to alloy material technical field.The application is when preparing corrosion-resistant magnesium alloy material, pure magnesium, pure zinc, pure aluminum, magnesium gadolinium intermediate alloy and magnesium calcium intermediate alloy are fused and refined to obtain as-cast magnesium alloy;As-cast magnesium alloy is sequentially subjected to solid solution treatment, aging treatment, is extruded and is spun to obtain fine-grained magnesium alloy;After fine-grained magnesium alloy is cut and sampled, micro-arc oxidation is carried out, and then treated by 3-aminopropyl triethoxysilane alcoholysis solution to obtain pretreated magnesium alloy;Urea, formaldehyde are wrapped 2-mercapto benzothiazole to carry out in-situ polymerization to prepare corrosion-inhibiting microcapsule;Dimethyl imidazole, corrosion-inhibiting microcapsule and epoxy resin are spin-coated on the surface of pretreated magnesium alloy to prepare corrosion-resistant magnesium alloy material.The corrosion-resistant magnesium alloy material prepared by the application has excellent corrosion resistance, tensile strength and wear resistance.

This invention discloses a fluorescent probe for detecting hypochlorite based on the synergistic effect of ESIPT and AIE in a benzothiazole structure, its preparation method, and its application, belonging to the field of fluorescent probe technology. The invention uses 2-aminobenzylthiophenol and 2-hydroxy-5-methoxybenzaldehyde as starting materials, condensing them to form a benzothiazole derivative as the fluorescent core. A diaminomaleitrile recognition group is introduced through an aldehyde-amine condensation reaction to synthesize the fluorescent probe. After the probe undergoes a specific oxidation reaction with hypochlorite, the C=N double bond breaks, and the ESIPT and AIE effects are synergistically activated, resulting in a significant enhancement of fluorescence. This probe exhibits a fast response, a linear range of 0-200 μM, a detection limit of 29.1 nM, excellent selectivity and anti-interference properties, and stability under pH 6-10 conditions, making it suitable for highly sensitive detection of hypochlorite in aqueous solutions and complex systems.

This invention belongs to the field of pharmaceutical technology, specifically relating to the crystal form of 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole (compound of formula I) and its preparation method. The X-ray powder diffraction pattern of crystal form F of compound I shows diffraction peaks at 2θ values ​​of 12.0°, 14.0°, 16.5°, 20.3°, 21.7°, 23.9°, 24.5°, 28.0°, 28.8°, and 30.1°, with an error range of ±0.2° for the 2θ values. Compared with existing type II and type I crystals and hydrates of compound I, crystal form F of compound I exhibits lower hygroscopicity, higher solubility, and better flowability, thus possessing value for pharmaceutical industrial applications.

This invention relates to a benzothiazole or benzimidazole derivative, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the derivative as an active ingredient for the prevention or treatment of diseases related to the Silent Information Modulator (SIRTUIN) 7 protein, which exhibits excellent inhibitory activity against the SIRTUIN 7 protein and can be used for the prevention or treatment of diseases related to the SIRTUIN 7 protein.

The present application provides a 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole compound bulk drug, wherein the particle size D90 of the compound bulk drug is 70-5 μm. The present application also provides a composition comprising the bulk drug and an excipient. The bulk drug or the composition is used in the preparation of a drug for promoting the excretion of uric acid. The bulk drug of the present application can make the pharmaceutical composition comprising the same have better content uniformity and faster dissolution rate.

The application relates to the technical field of organic synthetic chemistry, and particularly discloses a 2-acyl benzothiazole derivative and a preparation method thereof. The method takes benzothiazole compounds and aromatic aldehyde compounds as substrates, takes polyacid such as phosphomolybdic acid as a catalyst, and generates the 2-acyl benzothiazole derivative through cross-dehydrogenative coupling in an organic solvent under the conditions of air or oxygen atmosphere and light irradiation. The application does not need a transition metal catalyst and an alkaline additive, uses oxygen as a terminal oxidant, the catalyst can be recycled and reused, the reaction condition is mild, the operation is simple, the applicable range of the substrate is wide, the chemical selectivity is high, and the product yield can reach 85%. The method overcomes the limitations of safety, selectivity and scale of the prior art, and provides an efficient, economical and environment-friendly new path for the preparation of high-value 2-acyl benzothiazole derivatives in the fields of medicine, pesticide and material science.

The application provides a D-A type organic fluorescent small molecule based on 2-(2-aminophenyl) benzothiazole, a preparation method and application in phosgene and sarin detection, and belongs to the technical field of fluorescent sensing. The D-A type organic fluorescent small molecule provided by the application is composed of 2-(2-aminophenyl) benzothiazole and an electron-donating group. 2-(2-aminophenyl) benzothiazole serves as an electron-accepting group, and after the introduction of the electron-donating group, an intramolecular charge transfer state can be formed, thereby constructing the D-A type organic fluorescent small molecule. Meanwhile, 2-(2-aminophenyl) benzothiazole serves as a recognition site for sensing reaction and interacts with phosgene and a nerve toxicant molecule through different sensing mechanisms, thereby exhibiting completely different fluorescence responses, so that the purpose of integrated detection of multiple hazardous substances is achieved. After the material is made into a sensor, efficient fluorescence colorimetric detection of trace phosgene and nerve toxicant molecules in liquid and gas phases can be realized, and the material has the advantages of high sensitivity, good selectivity and strong anti-interference ability. Further, by combining a smart phone to perform RGB analysis on the image of the filter paper fluorescent sensor of the material, the RGB value of the image can be output in real time, thereby realizing visual quantitative fluorescence detection of phosgene and nerve toxicant molecules.

The present disclosure relates to a process for manufacturing lanifibranor which comprises reacting N-(4-chloro-2-iodo-phenyl)-1,3-benzothiazole-6-sulfonamide with 5-hexynoic acid in the presence of a Palladium catalyst and a copper salt.

This invention relates to the field of organic synthesis technology and discloses a crown-ether aromatic dicarboxylic acid and its preparation method. The crown-ether aromatic dicarboxylic acid has the structure of Formula 1, wherein Ar1 represents crown ether units with different numbers of crowns, where n takes the value of 4-10, and Ar2 is a side chain substituent, which can be selected from one or more of H, halogen, -OH, -SO3, -NO2, and -H2PO4. The preparation of the crown-ether aromatic dicarboxylic acid provided by this invention is divided into two steps. First, the aromatic crown ether containing a benzene ring reacts with acetyl chloride in a low-boiling-point organic solvent to generate an acetyl aromatic crown ether. The organic solvent is removed by rotary evaporation, reducing complex purification steps. Finally, the crown-ether aromatic dicarboxylic acid is prepared by oxidation in liquid bromine and 1,4-dioxane. The synthesized crown-ether aromatic dicarboxylic acid is prepared in two continuous steps, with high purity, suitable cost, and applicable to large-scale production processes. It has important application value in the preparation of polyesters, polyamides, polybenzimidazoles, polybenzothiazoles, and related high-performance polymers and pharmaceutical intermediates.

The application discloses an indole derivative containing benzothiazole and pyridine as well as a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. The application introduces benzothiazole and pyridine groups with excellent activity into the structure of indole, and synthesizes a series of indole derivatives containing benzothiazole and pyridine. Through inhibition of plant pathogenic bacteria activity test on the synthesized indole derivatives containing benzothiazole and pyridine, it is found that the synthesized indole derivatives containing benzothiazole and pyridine can effectively inhibit plant pathogenic fungi, especially pepper phytophthora blight.

The present invention relates to salts of benzothiazole compounds of formula I selected from pamoate and palmitate salts, their crystalline forms and uses, and further to the use of salts of the compound of formula I and its crystalline forms in the manufacture of medicaments for the treatment of Parkinson's disease and restless legs syndrome. JPEG2023550235000032.jpg28170

Disclosed in the present invention are a desulfurized-rubber-modified asphalt and a preparation method therefor. The asphalt of the present invention comprises, in parts by mass, 100 parts of petroleum asphalt, 25-35 parts of desulfurized rubber powder, 0.2-2 parts of an oxime-sulfonate-based modifier, and 0.5-3 parts of a modified artificial zeolite, wherein starting materials of the desulfurized rubber powder comprise waste rubber powder, calcium nitrate, aniline, 2,5-benzothiazole dithiol, p‑tolylmagnesium bromide, diphenyl sulfoxide, and trimethylchlorosilane in a mass ratio of 80-100:10-20:20-30:5-10:5-6:1:3-4. Further disclosed in the present invention is a specific preparation method for the desulfurized rubber powder. The asphalt of the present invention has simple components, improved properties and low blending temperature and is more convenient to use.

The present disclosure is directed to a process for preparing lanifibranor comprising: a) reacting 5-chloroindole with 2-(4-bromobutoxy)tetrahydropyran in a solvent; b) reacting the compound obtained in step a) with 1,3-benzothiazole-6-sulfonyl chloride in a solvent; c) deprotecting the compound obtained in step b); d) oxidizing the compound obtained in step c).