297 results about "Benzothiazole" patented technology

The invention discloses a copper surface micro-etching coarsening solution for a fine circuit as well as a preparation method and application of the copper surface micro-etching coarsening solution, and relates to the technical field of printed circuit board manufacturing. The copper surface micro-etching coarsening solution for the fine circuit is prepared from, by mass concentration, 60 g / L to 100 g / L of sulfuric acid, 40 g / L to 60 g / L of hydrogen peroxide, 0.5 g / L to 2 g / L of zinc sulfate, 10 g / L to 30 g / L of copper ions, 0.5 g / L to 1 g / L of pyridine heterocycle-containing Schiff base, 10 g / L to 100 g / L of ethyl alcohol, 1 g / L to 3 g / L of 2-mercaptobenzothiazole, 1 g / L to 5 g / L of methionine and 1 g / L to 5 g / L of polyacrylamide. According to the copper surface micro-etching coarsening solution, the 2-mercaptobenzothiazole and the methionine in the copper surface micro-etching coarsening solution can enable the copper surface to form a honeycomb structure under the low micro-etching amount, the zinc sulfate and the pyridine heterocyclic ring-containing Schiff base can form a composite film layer with copper ions on the surface of the honeycomb structure, and the interlayer binding force is improved.

The invention discloses a continuous reaction device and method for producing 2-amino-4-methylbenzothiazole, and belongs to the technical field of compound production. The invention relates to a continuous reaction device for producing 2-amino-4-methylbenzothiazole, which comprises a first-stage reaction kettle and further comprises a stirring mechanism arranged in the first-stage reaction kettle and used for stirring chlorine and a mixed solution in the first-stage reaction kettle; the driving mechanism is arranged at the top of the first-stage reaction kettle and is used for driving the stirring mechanism to perform stirring action in the first-stage reaction kettle; the chlorine injection mechanism is connected with the stirring mechanism; the air exhaust mechanism is arranged at the top of the first-stage reaction kettle and is connected with the driving mechanism; the multistage reaction kettles are adopted for continuous operation to eliminate downtime, so that the problem of low production efficiency caused by repeated heating and cooling due to the use of intermittent reaction kettles in the traditional process is solved, the chlorine utilization rate is improved, and the production and processing cost is effectively reduced.

The present invention discloses a high thermal conductivity rubber material and a preparation method thereof, and relates to the technical field of rubber production, the high thermal conductivity rubber material comprises a rubber matrix, modified carbon black, a vulcanizing agent, a composite accelerator, an anti-aging agent, zinc oxide, stearic acid, white carbon black, montmorillonite and aramid pulp according to a weight ratio of 100: (40-60): (1.5-3): (2-4): (1-3): (3-8): (1-3): (10-20): (5-15): (3-8); the modified carbon black is prepared by reacting a composite modifier solution prepared from a silane coupling agent, sodium alginate, ammonium polyacrylate, tea polyphenol, polyethyleneimine, nano aluminum oxide and deionized water with carbon black; the composite accelerant is prepared by carrying out pre-dispersion treatment on N-cyclohexyl-2-benzothiazole sulfenamide, tetramethylthiuram disulfide, a rare earth complex and nano zinc oxide. The prepared high-thermal-conductivity rubber material is good in mechanical property and thermal conductivity.

The invention discloses an iron-loaded sulfonated carbon nitride heterogeneous catalyst as well as a preparation method and application thereof, and belongs to the field of heterogeneous catalysts. The iron-loaded sulfonated carbon nitride heterogeneous catalyst consists of monatomic Fe and a sulfonated graphite phase carbon nitride carrier, so that the prepared iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the reaction of benzoxazole and absolute ethyl alcohol, is high in catalytic efficiency, can catalyze the reaction of benzimidazole or benzothiazole and absolute ethyl alcohol, and is high in catalytic efficiency. Therefore, 2-(1-hydroxyethyl)-benzimidazole or 2-(1-hydroxyethyl)-benzothiazole is synthesized, and concentrated acid does not need to be used as a catalyst in the synthesis process. The sulfonation degree of the iron-loaded sulfonated carbon nitride heterogeneous catalyst can be regulated and controlled, the iron-loaded sulfonated carbon nitride heterogeneous catalyst can catalyze the construction of a directional C-C bond, and the iron-loaded sulfonated carbon nitride heterogeneous catalyst keeps stable in the reaction process and can be recycled for 5 times or more.

The invention relates to a diptera adult insecticide, which contains an insecticidal functional component n-butyl alcohol. According to the invention, n-butyl alcohol which has an obvious poisoning effect on the adult cucurbita petiolatus is separated from a metabolite of a bacillus thuringiensis XLB2910 strain, and 2, 3, 5-trimethylpyrazine and benzothiazole which have an obvious poisoning effect on the adult aedes albopictus are also separated from the metabolite of the bacillus thuringiensis XLB2910 strain. Through poisoning concentration analysis of different components and a compound combination experiment, a series of pesticides for adult cucurbita petioles and adult aedes albopictus are formed, the prepared compound pesticide for cucurbita petioles comprises 2.5%-10% of 2, 3, 5-trimethylpyrazine, 2%-10% of benzothiazole and 5%-10% of n-butyl alcohol, and the prepared compound pesticide for aedes albopictus comprises 2.5%-10% of 2, 3, 5-trimethylpyrazine, 2%-10% of benzothiazole and 5%-10% of n-butyl alcohol. The composition comprises 0.5%-3% of 1, 3, 5-trimethylpyrazine, 0.05%-1.5% of benzothiazole and 1%-3% of n-butyl alcohol. The compound insecticide has a good insecticidal effect on cucurbita petiolatus adults and aedes albopictus adults, and is wide in raw material source and environment-friendly.

The invention discloses a tetrahydrocarbazole enhanced fluorescent probe for detecting hydrosulfite as well as a preparation method and application of the tetrahydrocarbazole enhanced fluorescent probe. The fluorescent probe is a 2-(2-(5-(2, 2-dimethyl-2, 3, 4, 9-tetrahydro-1H-1, 3-methyl carbazole-6-yl) furan-2-yl) vinyl)-3-ethyl benzothiazole-3-onium iodised salt compound, namely, TC-FV-BT, and the fluorescent probe can be applied to the field of fluorescence detection. The probe TC-FV-BT can be used for specifically recognizing the hydrosulfite. Under sunlight, after bisulfite is added into a DMF / H2O (2: 8, v / v) solution of the probe TC-FV-BT, the color of the solution is changed from dark pink to white, under irradiation of ultraviolet light with the wavelength of 365 nm, the solution emits orange fluorescence at the emission wavelength of 605 nm, the fluorescence color of the solution is changed from colorless to orange, the response time is 4 min, the detection limit of the bisulfite reaches 77.27 nM, and the detection limit of the bisulfite reaches 77.27 nM. The fluorescent probe shows good selectivity and anti-interference performance, and has a good application prospect in the fields of environmental analysis, food and the like as a fluorescent probe for detecting hydrosulfite.

The invention provides a copper etching solution with a high etching factor as well as a preparation method and application of the copper etching solution. The copper etching solution with the high etching factor comprises the following components in parts by weight: 0.48-3 parts of a corrosion inhibitor; 1-10 parts of an oxidizing agent; 10 to 20 parts of inorganic acid; 0.1-1 part of an organic solvent; 60 to 80 parts of ultrapure water; the corrosion inhibitor is a mixture of a benzothiazole corrosion inhibitor and an aminoimidazole corrosion inhibitor. The copper etching liquid with the high etching factor has the high etching factor, copper can be rapidly and efficiently removed, the side wall etching time is shortened, and therefore the product yield is increased. And the method has very good application prospect and large-scale industrial popularization potential in the field of circuit board packaging.

This invention discloses an analytical method for benzothiazole contaminants, comprising the following steps: detection by high performance liquid chromatography (HPLC), with the following chromatographic conditions: a phenylhexyl column as the stationary phase, mobile phase A being water, mobile phase B being acetonitrile, and gradient elution; wherein the benzothiazole contaminants are at least one of 2-aminobenzothiazole, 2-hydroxybenzothiazole, benzothiazole, 2-methylbenzothiazole, 2-mercaptobenzothiazole, 2,5-dimethylbenzothiazole, 2-cyanobenzothiazole, ethyl 2-carboxylate benzothiazole, 2-chlorobenzothiazole, 2-bromobenzothiazole, 2-methylthiobenzothiazole, phenylthiocyanate, N-tert-butyl-2-benzothiazole sulfenamide, 2-(2-hydroxyphenyl)-benzothiazole, N-cyclohexyl-2-benzothiazole sulfinamide, dibenzothiazole disulfide, and N,N-dicyclohexyl-2-benzothiazole sulfonamide.

An attractant for Telenomus remus Nixon to control Spodoptera litura Fabricicus is provided. The attractant includes a solvent and at least one of the following components: 1,3-dichlorobenzene, benzothiazole, and octane. The attractant can effectively attract Telenomus remus Nixon to parasitize Spodoptera litura Fabricius eggs, such that the growth of a pest quantity is inhibited and the pest population gradually dies out, which achieves the purpose of pest control. The attractant is a green, non-toxic, and pollution-free attraction substance. Therefore, the attractant can solve a series of problems such as pesticide residues, environmental pollution, and food safety caused by chemical control, and is of great significance for the green control of Spodoptera litura Fabricius.

The invention discloses a flexible glass cutting fluid and a preparation method thereof, and the preparation method comprises the following steps: S1, adding cellobiose into DMF, then adding chloroacetic anhydride and pyridine, and carrying out a stirring reaction to obtain an intermediate; s2, adding the intermediate into DMF (Dimethyl Formamide), and then carrying out constant-temperature reaction on glycerol monocaprylate, 2-(2-hydroxyphenyl) benzothiazole and triethylamine to obtain a modifier; s3, uniformly mixing a modifier, sodium dioctyl sulfosuccinate and a polyoxyethylene polyoxypropylene block copolymer, so as to obtain a composite surfactant; s4, adding the composite surfactant, the propylene glycol, the defoaming agent, the sterilizing agent and the triethanolamine into the water, and uniformly stirring to obtain the cleaning agent. According to the prepared cutting fluid, the protection effect on a flexible glass base material and a surface functional layer of the flexible glass base material is remarkably improved while the excellent wettability is kept, microcrack generation and surface damage in the cutting process are reduced, and the cutting fluid is particularly suitable for precise glass processing of flexible display devices.

The invention provides a method for synthesizing nitrogen-substituted 2-aminobenzothiazole from 2-aminobenzothiazole, which comprises the following steps: in the presence of a Cu-MOF catalyst, carrying out C-N coupling reaction on a compound as shown in a formula II, a compound as shown in a formula III and an alkali solution to obtain a nitrogen-substituted 2-aminobenzothiazole compound as shown in a formula I; in the formula I and the formula III, R1 is independently selected from substituted or unsubstituted aryl respectively; in the formula I and the formula II, R2 is independently selected from halogen and / or alkyl respectively; in the Cu-MOF catalyst, the outer surface of an MOF material is coated with metal Cu, the Cu-MOF catalyst is of a porous structure, the porosity of the Cu-MOF catalyst is 12-18%, and the pore size of the Cu-MOF catalyst is 3-5. The preparation method provided by the invention is simple to operate, mild in reaction condition, relatively high in reaction efficiency and suitable for large-scale production, and has a wide application prospect.

The invention relates to the technical field of NBR composite materials, in particular to a low-temperature-resistant wear-resistant NBR composite material and a preparation method and application thereof. The invention provides a low-temperature-resistant wear-resistant NBR (nitrile-butadiene rubber) composite material, which is prepared from the following components in parts by mass: 100 parts of NBR raw rubber, 2 to 6 parts of zinc oxide, 0.5 to 2 parts of stearic acid, 30 to 80 parts of carbon black, 1 to 3 parts of 2-mercaptobenzimidazole, 2 to 12 parts of oleylamine grafted halloysite nanotubes, 0.5 to 2 parts of sulfur and 0.5 to 4 parts of N-cyclohexyl-2-benzothiazole sulfenamide. According to the low-temperature-resistant wear-resistant NBR composite material, the compatibility of the additive and the NBR raw rubber is good, and the blooming phenomenon is avoided.

The present application belongs to the technical field of fine chemical industry, and relates to a recycling method of accelerator M tar. In the waste M tar produced in M production, a catalyst is added, high-temperature decomposition is carried out under nitrogen protection, and recycled raw materials aniline, carbon disulfide and intermediate benzothiazole and the like are obtained, most of which are recycled. The present application adopts common equipment and unit operations, the catalyst can be reused, and the treatment of production waste is easy to realize industrial production.

The invention discloses a nitrogen-doped graphene composite material and a preparation method thereof, and belongs to the technical field of composite materials. The preparation method comprises the following steps: S1, preparing a nitrogen-doped graphene material; s2, dissolving indium nitrate, 2-amino-benzothiazole and the nitrogen-doped graphene material in a DMF (Dimethyl Formamide) aqueous solution, carrying out hydrothermal reaction, cooling to room temperature, washing and freeze-drying to obtain a nitrogen-doped graphene / indium-based MOF (Metal Organic Framework) material; and S3, adding the nitrogen-doped graphene / indium-based MOF material into the lead acetate dispersion liquid, carrying out ultrasonic treatment, stirring and uniformly mixing, dropwise adding a 2g / L sodium hydroxide solution into the mixed liquid in a stirring state until the solution Ph is 8, then carrying out freeze drying, putting a dried sample into a tubular furnace, and calcining in an inert atmosphere to obtain the nitrogen-doped graphene composite material. When the prepared composite material is applied to the negative electrode of the lead-acid battery, the hydrogen evolution side reaction in the charging process of the negative electrode plate can be remarkably reduced, and the electrochemical performance of the battery is improved.

The invention belongs to the technical field of electrochromic polymers, and particularly relates to an electrochromic polymer, a film and a preparation method of the film. The preparation monomer of the electrochromic polymer is 2-(heptan-3-yl)-4, 7-bis (thieno [3, 2-b] thiophen-2-yl) benzo [d] thiazole, the monomer can be directly synthesized through the reaction of 4, 7-dibromo-2-(heptane-3-yl) benzothiazole and (thieno [3, 2-B] thiophene-2-yl) tributyltin, and the steps are simple and convenient. The polymer is yellow in a neutral state and blue in an oxidation state, coloring only needs 0.25 s, fading only needs 0.61 s, and the electrochromic response speed is high. The electrochromic polymer is prepared through a cyclic voltammetry method, and the generated polymer naturally deposits and grows on the surface of an ITO glass electrode and has a film form, so that the preparation steps of an electrochromic film are simplified, and the adhesive force between the film and a transparent conductive substrate is remarkably improved.

The application relates to the field of protective films and discloses a liquid crystal light guide plate high-transmittance tpe protective film and a preparation method thereof, which comprises SEBS, polypropylene, modified halloysite nanotubes, modified silicon dioxide and an additive; the modified halloysite nanotubes are prepared by the following steps: reacting a functional additive, which is prepared by grafting an isocyanate-oxidized antioxidant component and a modified benzothiazole-containing monomer, with 3-chloropropyl trimethoxysilane, and then grafting on the surface of the halloysite nanotubes; the isocyanate-oxidized antioxidant component is obtained by the following steps: reacting 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionic acid and N-hydroxymethyl acrylamide, and then reacting with 2-mercaptoethanol; and then, the isocyanate-oxidized antioxidant component is reacted with isophorone diisocyanate; the modified benzothiazole-containing monomer is prepared by the following steps: reacting 2-aminobenzothiazole and bromoacetyl bromide, and then reacting with 3,5-dihydroxybenzylamine; and the protective film prepared by the application has good heat-oxygen aging resistance, antibacterial property, heat resistance and tensile property.

The invention relates to the technical field of pesticide synthesis processes, in particular to a one-pot multi-component preparation method of a chiral Dufulin compound. The method comprises the following steps: mixing quinine, substituted benzyl bromide and a solvent, and refluxing to obtain a reaction solution; the preparation method comprises the following steps: mixing 2-amino-4-methylbenzothiazole, 2-fluorobenzaldehyde, a solvent and a catalyst, and then refluxing to obtain a reaction system; mixing the reaction system with diethyl phosphite, the reaction liquid and an alkali reagent, and stirring to react, so as to obtain a stirred reaction material; and extracting the stirred reaction material with an extraction liquid, separating the liquid to obtain an organic phase, washing the organic phase with water, and removing the solvent to obtain the chiral Dufulin compound. According to the invention, low-cost clean synthesis of chiral Dufulin is realized; the preparation method disclosed by the invention is reasonable in design, mild in reaction condition, easy to obtain raw materials, convenient to operate, high in product yield, suitable for large-scale production and good in industrial replicability.

The application relates to a salt type of a new cell cycle regulatory kinase inhibitor and a crystal form and a preparation method thereof, and relates to a succinate salt of a compound (6-((4-(2-(diethylamino)benzo[d]thiazol-6-yl)-5-fluoropyrimidin-2-yl)amino)pyridin-3-yl)(4-isopropylpiperazin-1-yl)methanone and a crystal form thereof, wherein two crystal forms II and III of the succinate salt are good in stability, high in solubility, and the preparation method is simple and suitable for industrial production.

The present invention relates to benzoxazole and benzothiazole compounds or pharmaceutically acceptable salts thereof which are useful for the treatment of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (Exon19 deletion, L858R and the Del 19 / T790M and L858R / T790M resistance mutation). The compounds of the present invention and salts thereof are useful in the treatment or prevention of different types of cancers. The present invention also relates to methods of preparation for benzoxazole and benzothiazole compounds and pharmaceutically acceptable salts, stereoisomers, prodrugs and solvates thereof; a pharmaceutical composition containing the compounds, pharmaceutically acceptable salts, stereoisomers, prodrugs and / or solvates thereof particularly useful polymorphs of the compounds and salts thereof. The invention also relates to use of the compounds and pharmaceutically acceptable salts, prodrugs, stereoisomers, and solvates thereof in the preparation of a medicament for treating diseases associated with various forms of EGFR. The definitions of 'A', 'X', R1, R2, R3, and 'm' are as defined herein. Formula (I)

The application relates to the technical field of organic fluorescent probes, and particularly discloses a lipid droplet and hypochlorous acid sequence response type fluorescent probe, a structural formula of which is as shown in the figure; wherein R is a cyano group, a benzothiazole group, a benzimidazole group, an amido group, an ethoxycarbonyl group or an acetyl group. The precise imaging lipid droplet and hypochlorous acid sequence response fluorescent probe of the application takes a phenothiazine-coumarin dye support as a matrix, utilizes a double trifluoromethyl benzyl group as a lipid droplet targeting group, adjusts the dye emission wavelength by introducing different electron-withdrawing groups, synthesizes a series of probes, and realizes high-targeting sequence imaging of lipid droplets and hypochlorous acid in atherosclerotic plaques.

The invention relates to the field of cables, and discloses an aerial insulated cable, a protective layer of which is prepared from the following materials: low-density polyethylene, nitrile rubber, ethylene-vinyl acetate copolymer, modified composite filler, functional additive and the like. The modified composite filler is prepared by grafting a modified silane coupling agent and Na-montmorillonite loaded titanium dioxide; the modified silane coupling agent is prepared by reacting p-hydroxybenzaldehyde with phosphorus oxychloride, then carrying out addition with DOPO (9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide), reacting the obtained product with p-aminodiphenylamine, and then carrying out substitution with 3-chloropropyltriethoxysilane; the functional additive is prepared by the following steps: reacting 3, 5-di-tert-butyl-4-hydroxybenzaldehyde with 2-amino-4-methylbenzothiazole, then adding sodium borohydride for reductive amination, substituting the obtained product with cyanuric chloride, and then reacting with N-butyl-2, 2, 6, 6-tetramethyl-4-piperidylamine, and the functional additive is prepared by the following steps: reacting 3, 5-di-tert-butyl-4-hydroxybenzaldehyde with 2-amino-4-methylbenzothiazole; and the protective layer material is endowed with good flame retardance, antibacterial property and long-acting aging resistance.

The invention relates to the technical field of polymer foam materials, in particular to a rubber-based composite foam material for a middle layer of a shoe sole and a preparation method of the rubber-based composite foam material for the middle layer of the shoe sole. Adding a foaming agent, sulfur, an accelerant N-cyclohexyl-2-benzothiazole sulfenamide and tetrabenzylthiuram disulfide, and carrying out secondary internal mixing to obtain a uniformly mixed styrene butadiene rubber / natural rubber-based rubber compound; putting the rubber compound into an open mill, and discharging bubbles; and finally, carrying out high-temperature curing foaming on the rolled rubber compound by using a plate vulcanizer. The rubber-based composite foam material obtained by the invention has the characteristics of simple process, light weight, uniform foam holes, high elasticity and high tensile strength, and is suitable for middle-layer materials of soles.

The present invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators with apical sodium-dependent bile acid transporter (ASBT) and / or hepatic bile acid transport (LBAT) inhibitory activity. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases, and liver diseases.

The application belongs to the technical field of chemical synthesis, and particularly relates to a trifluoromethyl-containing benzothiazole tertiary alcohol derivative, a preparation method and application thereof. 1 , R 2 are independently selected from hydrogen, C1-C3 alkyl, C1-C3 alkoxy or halogen; or R 1 , R 2 independently form a naphthalene ring with the substituted benzene ring together. The trifluoromethyl-containing benzothiazole tertiary alcohol derivative provided by the application has good bacteriostatic effect on one or more of Rhizoctonia solani, Fusarium moniliforme, Fusarium graminearum, Fusarium oxysporum and Phytophthora nicotianae.

The invention discloses oxidized paraffin and antirust wax and a preparation method thereof, and relates to the field of paraffin. The antirust wax comprises oxidized paraffin, an emulsifier, an antirust agent and water, and the emulsifier is at least one of sorbitan monooleate, lauryl sodium sulfate and fatty alcohol-polyoxyethylene ether; the antirust agent is at least one of cyclohexylamine stearate, alkenyl succinic acid and alpha-mercaptobenzothiazole; the oxidized paraffin is loaded with a Mn metal element through a carrier. The catalyst loaded with the active component Mn is added in the preparation process of the oxidized paraffin, the acid value and the soap value of the oxidized paraffin are effectively increased, the oxidized paraffin interacts with the specific emulsifier and the antirust agent, the emulsifier does not affect the anti-oxidation protection function of functional components, and meanwhile, the antirust agent and the oxidized paraffin cooperate with each other to achieve the anti-corrosion effect in a synergistic mode; and the antirust capability of metal in a humid and hot environment and an acid-base environment is improved, and the application prospect is expanded.

The application discloses a kind of polysubstituted phenol derivatives and electrochemical preparation method thereof, which uses 2-(benzo[d]thiazole-2-yl)-4-substituted phenol, substituted pyrazole or benzimidazole as raw material, tetrabutylammonium tetrafluoroborate as electrolyte, a mixture of hexafluoroisopropanol and dichloromethane (volume ratio 7:3) as solvent, direct electrolysis reaction under air atmosphere at room temperature to obtain the target product shown in formula one or formula two. Research has found that such products have good solid fluorescence and exhibit aggregation-induced emission properties in tetrahydrofuran and water systems. The method of the application has the advantages of simple operation, good compatibility of substrate functional groups, mild conditions, low production process cost and environmental friendliness.

The invention relates to the technical field of organic electrochemical synthesis, and discloses a carborane cage boron free radical and a preparation method and application thereof.The structural formula of the carborane cage boron free radical is shown in the formula I. The preparation method has the advantages that in-situ generation of boron free radicals under the electrochemical condition is achieved for the first time; a B-N bond of diazo-carborane tetrafluoroborate is electrochemically reduced to generate a boron center free radical with reaction activity, the free radical can efficiently initiate a series cyclization reaction of 2-isocyano aryl sulfide, and a carborane benzothiazole skeleton is constructed in one step.

The invention relates to a method for preparing a hydroxyl naphthaldehyde derivative by using a cobalt complex, which comprises the following step: by taking naphthol and paraformaldehyde as raw materials and the cobalt complex containing an ortho-carborane benzothiazole structure as a catalyst, reacting at room temperature to synthesize the hydroxyl naphthaldehyde derivative. Compared with the prior art, the cobalt complex containing the ortho-carborane benzothiazole structure is applied to the reaction for catalytically synthesizing the hydroxyl naphthaldehyde derivative through the one-pot method, the use equivalent of the catalyst is low, the reaction condition is mild, the substrate universality is high, and the yield is high.