371 results about "BODIPY" patented technology

Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

The invention relates to a boron fluoride dipyrrole fluorescent dye containing hydrophilic groups and a preparation method thereof. The preparation method comprises the steps of introducing hydrophilic groups to a fluorine atom at 4 bit and fluorine atoms at 2 and 6 bits of BODIPY (boron dipyrromethene dyes) respectively to obtain relatively good water solubility of a whole molecule, wherein the hydrophilic groups are 3-dimethyl amino-1-propyne; enabling 2,4-dimethyl pyrrole to react with aldehyde or acyl chloride containing different substituent groups under catalysis of trifluoroacetic acid according to a molar ratio of 2:1, and then oxidizing by using DDQ (dichloro dicyano quinone) to obtain a basic BODIPY parent structure. The new synthetic method of a quaternary ammonium salt water-soluble BODIPY dye, disclosed by the invention, is simple in reaction condition and relatively high in yield. The BODIPY dye with 3-dimethyl amino-1-propyne groups has a relatively good aggregation property; the obvious aggregation process can be observed in the solution of water and dimethyl sulfoxide; moreover, the fluorescence spectrum of an aggregate has a sharp peak shape, and the strength of the aggregate is extremely high.