13 results about "BODIPY" patented technology

The application provides a method for monitoring lipid oxidation tendency, and belongs to the technical field of fluorescent probe detection. The method utilizes the fluorescence characteristics of a BODIPY molecular probe, and through selecting a molecular probe with a specific structure, directional reaction occurs between the BODIPY molecular probe and oxygen free radicals generated by lipid oxidation at a specific pH value. The conjugated system of the BODIPY molecular probe is destroyed, the half-chlorin structure is broken, and the fluorescence color changes from red to blue-green. According to the change of the fluorescence color before and after the reaction, the visualization monitoring of the lipid oxidation tendency and spatial distribution is realized through fluorescence imaging.

A molecular probe for selective detection of a nitrate and / or a decomposition product of a nitrate by generating a fluorescence signal in response to an excitation in the wavelength range between 340-370 and 480-520 nm, wherein the molecular probe is selected from a triarylborane dye according to formula (7) and a BODIPY™ (boron-dipyrromethene) dye according to formula (13):

The application discloses an MMP-2 responsive targeted brain glioma synergistic diagnosis and treatment and immune activation nano probe and a preparation method and application thereof, and relates to the technical field of biological medicine. The probe is formed by assembling an Angiopep-2 targeting peptide, an MMP-2 response sequence, a chemotherapeutic drug and a photosensitizer I-BODIPY, has a hydrodynamic diameter of 10-50 nm, and has excellent biocompatibility. The probe is combined with an LRP1 receptor through the Angiopep-2 to cross the blood-brain barrier, is specifically cut by MMP-2 in a tumor microenvironment to release drugs at a fixed point, integrates the functions of chemotherapy, photothermal / photodynamic therapy and fluorescence imaging, synchronously activates immunogenic cell death and paraptosis, and reshapes an anti-tumor immune microenvironment. The probe can realize precise targeting of brain glioma, synergistic diagnosis and treatment, immune activation and tumor staging evaluation, significantly prolongs the survival period of tumor-bearing mice, and provides a new scheme for glioblastoma diagnosis and treatment.

The application discloses a compound Cl-BODIPY used as a fluorescent probe for rapid nondestructive detection of food freshness, and also establishes a corresponding preparation method and detection method. The probe produces a color and fluorescent dual optical signal change through specific interaction of a recognition group with volatile biogenic amines, and provides a simple and convenient detection method for rapid detection of volatile biogenic amines. The fluorescent probe is simple to prepare, low in cost, and has the characteristics of high sensitivity, high selectivity and rapid response, can in-situ rapidly detect volatile biogenic amines produced by fish and meat food spoilage, and judges the freshness (biogenic amine content) of fish and meat through colorimetric and fluorescent dual visual signal changes, thereby providing an effective means for rapid nondestructive detection of food freshness, having great application prospect and great popularization significance.

This invention relates to the field of organic synthesis technology, and particularly to a dual-fluorescent probe for Bodipy and NBD, its synthesis method, and its application. The method includes: first, synthesizing NBD coumarin compound 6; then, using nitrobenzaldehyde f and dimethylpyrrole as starting materials, undergoing a four-step one-pot cascade reaction with catalytic amounts of trifluoroacetic acid, DDQ oxidation, and excess triethylamine and Lewis acid boron trifluoride diethyl ether to obtain the fluorescent compound Bodipy h; finally, subjecting the fluorescent compound Bodipy h to reduction and acylation to obtain Bodipy fluorescent probe 8; and finally, after lithium hydroxide demethylation of Bodipy fluorescent probe 8 to obtain a carboxylic acid, which is then amidated with the deBoc-protected NBD compound 6 by trifluoroacetic acid to obtain the target product, dual-fluorescent probe 9. This invention anticipates that the fluorescence of coumarin and naphthalimide, through this dual quenching process, can efficiently achieve the quenching strategy, and can be applied to the simultaneous detection of H2S and hNQO1 in vivo or in vitro.

This disclosure generally relates to photoluminescent composites, and to color conversion films including the photoluminescent composites and their use in backlight units and display devices. In one embodiment, the photoluminescent composite includes a boron-dipyrrole methylene (BODIPY) moiety covalently bonded to the portion absorbing blue light.

This invention discloses BODIPY dyes, their preparation methods, and their applications in latent fingerprint recognition. The invention prepares four BODIPY dyes with different structures and emission colors, all exhibiting high fluorescence quantum yields (over 55% absolute fluorescence quantum yield) and excellent lipophilicity. Using a spray method, latent fingerprints on different substrates can be efficiently and conveniently detected within 10 seconds. Furthermore, the detection solution demonstrates excellent stability, can be stored for up to 30 days, and achieves a color change from green to red through modulation. This modulation effectively addresses complex background colors, ensuring optimal latent fingerprint detection results under various color backgrounds.

This invention relates to one-dimensional chain-like organometallic complexes grafted with imine-linked fluorescent groups, their preparation methods, and applications, belonging to the technical field of organometallic complex materials. The preparation method provided by this invention includes the following steps: S1, in a round-bottom flask, triazole ligands are coordinated with transition metal sulfates to obtain a series of one-dimensional chain-like organometallic complexes; S2, the one-dimensional chain-like molecules are dispersed in a solution, and the fluorescent group Bodipy is added. A Schiff base reaction occurs under an inert gas atmosphere and with the aid of a catalyst to obtain the one-dimensional chain-like fluorescent organometallic complexes. The method described in this invention is simple to operate, has a short reaction time, and exhibits higher stability compared to traditional organic fluorescent molecules, showing broad application prospects in chemical and biological sensing.

This invention discloses a method for the separation and detection of exosomes in whole blood using a microfluidic chip. The method includes preparing a microfluidic chip with a specific structure for whole blood exosome separation and a PEGylated microfluidic chip with fishbone-like protrusions for capturing whole blood exosomes. Simultaneously, a viscoelastic solution is prepared and the whole blood sample is pretreated. The pretreated whole blood sample is injected into the microfluidic chip for whole blood exosome separation, and size-dependent separation of exosomes is achieved using a viscoelastic flow field. After concentration, a whole blood exosome concentrate is obtained. Exosomes are immobilized with paraformaldehyde, perforated, and biotinylated. After capture, a BODIPY polymer dot-coupled secondary antibody is prepared, combined with a primary antibody to complete exosome immunolabeling. After localization, multi-channel imaging using a total internal reflection fluorescence microscope is performed. This method achieves efficient separation and highly specific labeling detection of whole blood exosomes, improving the separation recovery rate and purity.