121 results about "Unsaturated ketone" patented technology

The present invention relates to the electrochemical oxidation of allylic C- H bonds in specific compounds to obtain specific α,β unsaturated ketones in the presence of t-butyl hydroperoxide. This process is particularly suitable for the electrochemical oxidation of cholesterol, stigmasterol, campesterol, β-sitosterol, brassicasterol, 25-hydroxycholesterol, 24-hydroxycholesterol, lanosterol, pregnenolone, and the esters thereof.

The invention discloses a synthesis method of an unsaturated ketone or arone compound, which comprises the following steps: at a certain temperature, taking unsaturated hydrocarbon or aromatic hydrocarbon as a raw material, taking an N-hydroxyimide compound as a catalyst, adding an organic solvent for dissolving, introducing oxygen or air into a reaction solution under the irradiation of visible light, and carrying out oxidation reaction to obtain the unsaturated ketone or arone compound. And carrying out post-treatment separation to obtain the unsaturated ketone or arone. According to the method, air, oxygen-enriched gas or oxygen is used as a harmless oxidizing agent, visible light is used as an energy source to promote the reaction, and the method has the advantages that the reaction process is green and efficient, the cost is low, the dosage of the catalyst is small, and most of the catalyst can be recycled and reused; the atom economy is high.

The invention belongs to the technical field of preparation of transition metal organic photocatalysts, and particularly relates to design and a preparation method of a carbazole terpyridyl nickel catalyst. The invention aims to design and synthesize a carbazole terpyridyl nickel catalyst with light / nickel synergistic catalytic activity. The preparation method comprises the following specific synthesis steps: reacting different types of alpha-pyridone pyridinium and alpha, beta-unsaturated ketone in methanol, and carrying out suction filtration, washing, drying and other operations to obtain the corresponding carbazole terpyridyl ligand. The carbazole terpyridyl ligand and anhydrous nickel bromide are subjected to a heating reflux reaction in a tetrahydrofuran solution, and the corresponding carbazole terpyridyl nickel catalyst is obtained through methanol washing, suction filtration, drying and other operations. The terpyridyl nickel catalyst has high catalytic activity in a C-N, C-O and C-S coupling reaction promoted by visible light.

The invention discloses herbicidal activity application of unsaturated keto ester compounds, and belongs to the technical field of organic pesticides. The alkylamino-containing unsaturated keto ester compound can be used as an effective component for preparing a herbicide, and the prepared herbicide has a relatively good weed growth inhibition effect, is safe to commercial crops such as tomatoes, radishes and lettuce, and has a wide application prospect.

The invention belongs to the technical field of pesticides and chemical engineering, and particularly relates to a green preparation method of metconazole, which comprises the following steps: under the catalysis of alkali A, carrying out condensation reaction on cyclopentanone and benzaldehyde to obtain alpha, beta-unsaturated ketone; under the catalysis of alkali B, the alpha, beta-unsaturated ketone reacts with a methylation reagent to obtain double methylated alpha, beta-unsaturated ketone; under the action of a catalyst, the double-methylated alpha, beta-unsaturated ketone reacts with hydrogen to obtain 2, 2-dimethyl-5-benzyl cyclopentanone of which the double bonds are reduced; and reacting the 2, 2-dimethyl-5-benzyl cyclopentanone with a chlorination reagent under the action of a catalyst to obtain the 2, 2-dimethyl-5-(4-chlorobenzyl) cyclopentanone. According to the invention, cyclopentanone is used as a raw material to synthesize 2, 2-dimethyl-5-(4-chlorobenzyl) cyclopentanone through four-step simple reactions, metconazole is obtained through epoxidation and ring-opening substitution, and metconazole is finally obtained through recrystallization, so that the method has the advantages of cheap and easily available raw materials, simple process, environmental protection and the like, is suitable for long-term industrial development, and has wide application prospects. Good application prospects are realized.

The invention discloses a column [n] arene benzoquinone oxime ortho-position functionalized derivative and a preparation method thereof, and particularly relates to a preparation method for obtaining the column [n] arene benzoquinone oxime ortho-position functionalized derivative by reacting column [n] arene [1] benzoquinone oxime with a Grignard reagent. In the structure of column [n] arene [1] benzoquinone oxime, when alpha, beta-unsaturated ketone and a Grignard reagent are subjected to nucleophilic addition reaction, a 1, 4-addition product with high yield can be obtained, and no 1, 2-addition product exists. The method is mainly characterized in that protons can be removed from hydroxyl of oxime in column [n] arene [1] benzoquinone oxime under an alkaline condition, and oxygen negative ions of the hydroxyl are combined with positively charged metal magnesium atoms in a Grignard reagent to form a six-membered ring transition state, so that R negative ions can attack a No.4 carbon atom of alpha, beta-unsaturated ketone, and a 1, 4-addition reaction is carried out. The preparation method disclosed by the invention is mild in condition and can be carried out without harsh reaction conditions.

Multiphase polymers comprising crosslinking monomers and polyfunctional amine are disclosed. The multiphase polymer comprises a first phase polymer having a Tg from 60° C. to 240° C., a second phase polymer having a Tg from 40° C. to 240° C., and a soft phase polymer having a Tg from −25° C. to 30° C. The crosslinking monomers include a triacrylate such as trimethylol propane triacrylate, an unsaturated alkoxysilane, and an unsaturated keto monomer reactive with the polyfunctional amine. In contrast to conventional knowledge, incorporation of trimethylolpropane triacrylate reduces the minimum film forming temperature of multiphase polymers. This unusual reduction in MFFT helps to reduce the VOC requirement to form a good film at low VOC. The other crosslinking monomers including unsaturated alkoxy silane and unsaturated keto monomer which react with the polyfunctional amine improve print resistance, block resistance and lower the tackiness of paint films. The multiphase polymer is particularly suitable for use in deep base paints.

This invention provides a 1,3,5-triarylbenzene compound and its preparation method, which involves uniformly mixing α,β-unsaturated ketones, 2-phenylpropanal, and elemental iodine, followed by heating to react, thereby obtaining the compound. Compared with existing technologies, this invention has the following advantages: the reaction conditions are mild, the method is simple and rapid, and the substrate applicability is wide, which is beneficial for industrial production. Furthermore, the structure of the prepared 1,3,5-triarylbenzene compound is more complex and diverse.

The present invention belongs to the technical field of aviation fuel preparation, and specifically relates to a method for synthesizing thermally stable aviation kerosene from 2,5 - hexanedione. The method comprises the following steps: 1) Using 2,5 - hexanedione as a raw material and an alkali solution as a catalyst, an unsaturated ketone compound with twelve carbon atoms is obtained through an alkali - catalyzed aldol condensation reaction; 2) The unsaturated ketone compound obtained in step 1) undergoes a hydrodeoxygenation reaction under the action of a ternary mixed metal oxide catalyst to obtain a saturated cycloalkane liquid fuel with twelve carbon atoms containing alkyl decalin. The method of the present invention simplifies the current route for preparing alkyl decalin from biomass, and the intermediate products and the final product do not need to undergo a purification / distillation process; significantly reduces the production cost, the raw materials are cheap and easily available, the reaction conditions are mild, and it is suitable for large - scale industrial production.

The present invention relates to the technical field of organic synthesis, and particularly relates to a method for synthesizing furan compounds. Mix α,β-unsaturated ketone A, acylsilane B and an organic solvent, stir and react the mixed solution under the conditions of light and 0-30 °C, and then separate and purify to obtain the furan compound. The synthesis method of the present invention directly synthesizes furan compounds by a one-step method, which is a new reaction mode, provides a simple and efficient method for synthesizing polysubstituted furans, has simple, efficient and mild reaction conditions, does not require the addition of additional catalysts, has good functional group tolerance and substrate generality, can be compatible with various functional groups such as ester groups, halogens, carbonyl groups, and various linear or branched alkyl groups can also complete this reaction.

The present invention is a bicyclic acetylene alcohol compound characterized in that: a hydroxyl-substituted carbon atom in the compound is a tertiary carbon atom that bonds with an acetylene group and the α-carbon in the compound is a bridged carbon atom; a hydrogen atom is not present on the α-carbon atom; or both of these conditions are satisfied. The present invention thus makes it possible to provide a bicyclic acetylene alcohol compound in which an isomerization reaction to α, β-unsaturated ketone is unlikely to occur, an addition-curable silicone composition containing the compound, and a thermally conductive addition-curable silicone composition.

The present invention discloses a method for synthesizing pyrimidine compounds using a microchannel reaction device, wherein amidine compound I and α,β-unsaturated ketoxime ester compound II are used as reaction raw materials, and a pyrimidine compound shown in formula III is prepared using a microchannel modular reaction device under the action of a catalyst. Compared with the prior art, the present invention uses α,β-unsaturated ketoxime ester compounds and amidine compounds as substrates to prepare new pyrimidine compounds, and the method avoids multi-component reactions and uses cheap metal catalysts to quickly and efficiently synthesize products.

The application relates to the technical field of chemical synthesis, and particularly discloses a method for constructing cycloalkanol by nickel-catalyzed asymmetric hydrogenation of tri-substituted enone, and a chiral alcohol prepared by the method. The method uses alpha, beta-unsaturated ketone with different molecular structures as a substrate to construct chiral alcohol with double chiral centers, hydrogen is added to reduce the enyl group first, and then hydrogen is added to reduce the carbonyl group. In the case that the hydrogen on the carbon in the conjugated ring is replaced by different substituents, good reduction effect can be obtained. The catalyst has simple preparation mode and stable performance, and good chiral selection effect and conversion rate can still be obtained under the condition of high substrate / catalyst.

The invention discloses a preparation method of a trimethyl-1, 1, 1-trifluoromethyl allyloxy silane compound, and relates to the field of preparation of related products of pharmacy, agriculture and the like, in particular to preparation of the trimethyl-1, 1, 1-trifluoromethyl allyloxy silane compound by introducing a trifluoromethyl functional group into a carbonyl site of an alpha, beta-unsaturated ketone compound. The preparation method of the trimethyl-1, 1, 1-trifluoromethyl allyloxy silane comprises the following steps: by taking an alpha, beta unsaturated ketone compound as a raw material, adding a corresponding reaction reagent and catalyzing by microwave, thereby quickly obtaining a target product with high yield. According to the trimethyl-1, 1, 1-trifluoromethyl allyloxy silane compound provided by the invention, the preparation method is simple and easy, the yield is excellent, and a new thought is provided for trifluoromethylation reaction. The compound is proved to have good biological activity, can effectively inhibit the growth of human prostate tumor cells (PC-3), and has excellent anti-tumor potential.

This invention relates to the field of camel thorn separation and purification technology, specifically to unsaturated ketone components from camel thorn, their separation and extraction methods, and their applications. The unsaturated ketone component in camel thorn is (7S,3E,5Z)-7,8-dihydroxy-6-methylocta-3,5-dien-2-one. This invention discloses for the first time the unsaturated ketone components in camel thorn, and in vitro antitumor pharmacodynamic experiments were conducted on these components. The experiments showed that the unsaturated ketone components in camel thorn have a certain inhibitory effect on human HeLa cervical cancer cells, thus enabling their application in the preparation of drugs for the prevention / treatment of cervical cancer.

The invention discloses a method for preparing gamma, delta-unsaturated ketone by using oxalic acid and a mixed acid catalyst thereof. The invention provides a preparation method of a compound as shown in a formula I. The preparation method comprises the following steps: a compound as shown in a formula II and a compound as shown in a formula III are subjected to ketonization reaction at 90-120 DEG C in the presence of a catalyst to generate the compound as shown in the formula I. R1 is C1-C3 alkyl, R2 is C1-C16 alkyl or C2-C16 alkenyl; the catalyst is oxalic acid or mixed acid of oxalic acid and acid A; the acid A is selected from one or more of phosphorous acid, phosphoric acid, alkyl sulfonic acid or aryl sulfonic acid; in the mixed acid, the molar percentage content of the oxalic acid is greater than 50%. According to the preparation method, the reaction selectivity can be improved, and side reactions and high-boiling raffinate are reduced; the catalyst is low in cost, and the reaction system is high in yield. The preparation method disclosed by the invention is simple and convenient to operate, low in cost, green and environment-friendly.

The invention provides a catalytic synthesis method of an asymmetric chiral boron compound, and belongs to the technical field of asymmetric chiral boron compound synthesis. The catalytic synthesis method comprises the following steps: mixing an alpha, beta-unsaturated ketone compound, bis (pinacolato) diboron, a catalyst, a chiral ligand and a solvent, carrying out a reaction at room temperature for 6-24 h, and after the reaction is finished, carrying out post-treatment on the obtained mixed system to obtain the asymmetric chiral boron compound product. According to the method, the copper oxide nanosheet is used as the catalyst, when the synthesis of the chiral boron compound is catalyzed, the catalytic efficiency is high, the enantioselectivity is good, the method can be used for the chiral boron addition reaction of alpha, beta-unsaturated ketone compounds containing different substituent groups, and the substrate application range is wide; and the catalytic synthesis method can be carried out at room temperature, is mild in reaction condition, simple and easy to operate, avoids the use of alkali, is green and environment-friendly, and has potential industrial application value.

The invention discloses a synthesis method of novel alpha, beta-unsaturated ketone, which comprises the following steps: by taking aryl acyl chloride and olefin as raw materials, catalyzing the aryl acyl chloride through light-induced copper to generate acyl free radicals, and then carrying out free radical addition reaction and elimination on the acyl free radicals and the olefin, so as to efficiently construct an alpha, beta-unsaturated ketone compound. Compared with an existing method depending on an expensive iridium catalyst or organic dye, the method has the advantages that the cheap and high-yield copper catalyst is directly adopted, the production cost is remarkably reduced, and the economic benefit is improved. The method has the characteristics of mild reaction conditions, easily available catalyst and raw materials, use of clean and sustainable light energy as driving force, simplicity and convenience in operation and the like. The invention provides a new way which is economical, environment-friendly and easy for large-scale production for the synthesis of the alpha, beta-unsaturated ketone compound.

The invention provides a nitrogen-containing heterocyclic ring compound containing an unsaturated ketone structure, or a pharmaceutically acceptable salt or a stereoisomer or a prodrug molecule thereof, and a pharmaceutical composition and application thereof. The nitrogen-containing heterocyclic ring compound has a structure as shown in a formula (I) or a formula (II). The compound provided by the invention can effectively degrade RIOK2 protein, and has good inhibitory activity on various tumor cells. # imgabs0 #

The invention belongs to the technical field of medicines, and discloses a red fluorescent probe molecule activated by vicinal dithiol proteins (VDPs), which is used for monitoring the phenomenon of reduction-state VDPs content downloading in the brain of an ischemia reperfusion injury model mouse for the first time. The fluorescent probe has great advantages in the aspects of biological small molecule identification, protein marking and disease diagnosis, and is one of the most convenient and most popular tools for exploring a complex biological process. According to the invention, methacrylamide is taken as a recognition site to connect a fluorophore with an a-hydroxymethyl unsaturated ketone part, so that the fluorescent probe molecule capable of releasing red fluorescence after being activated by VDPs is obtained. The fluorescent probe molecule disclosed by the invention can be specifically combined with VDPs in a living body, so that the purposes of monitoring VDPs and diagnosing diseases are achieved.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to four kinds of DC-Rhoin analogues, which comprise at least two of a benzoheterocycle, a double bond in a heterocycle and an alpha, beta-unsaturated ketone structure of the double bond and a sulfonyl group, and a preparation method thereof is as follows: 3-acetylinde and triethylamine are sequentially added into a reaction bottle containing 1,2-dichloroethane, the reactants are added under ice bath, after normal temperature reaction, EtOAc and HCl are added for extraction; the organic phase is treated with saturated brine and anhydrous sodium sulfate, concentrated under reduced pressure and separated and purified through a silica gel column, and the DC-Rhoin analogue is obtained. The DC-Rhoin analogue can be used as a lead compound for preparing a RhoA inhibitor.

The invention relates to a crystal form of a compound containing alpha and beta unsaturated ketone and a preparation method of the crystal form, and belongs to the technical field of medicine crystal forms, the compound containing alpha and beta unsaturated ketone is 5-[2, 3-dichloro-4-(2-methylene butyryl) phenoxy methylene]-3-p-trifluoromethylphenyl-1, 2, 4-oxadiazole, the crystal form comprises a crystal form A, a crystal form B and a crystal form C, the compound has good chemical stability, is easy to dissolve and high in yield and purity, and provides a basis for dosage form research and clinical application of subsequent drugs.

This invention relates to the synthesis of carboxyl-terminated diunsaturated ketones with C=C double bonds at the α,β and γ,δ positions relative to the carbonyl carbon atom, or the β,γ and γ,δ positions. These ketones can be readily obtained from corresponding alkynyl alcohols with terminal carboxyl groups in a few steps. These ketones are important key building blocks for the synthesis of isoprene-like derivatives, especially vitamin E derivatives.

The application belongs to the technical field of organic chemistry, and particularly relates to a synthesis method of tri-substituted ethylene based on an alkyliden transfer strategy. The synthesis method comprises that, in the presence of an alkali or rare earth complex catalyst, a double (hetero) aryl methane or aryl heteroaryl methane and an alpha, beta-unsaturated ketone are subjected to an alkyliden transfer reaction in an organic solvent to form a corresponding tri-substituted ethylene product. The method has the advantages of small catalyst consumption, mild conditions, no additional additives, easy-to-obtain raw materials, strong reaction universality, simple operation, no salt-type waste, and only one organic by-product, i.e., a ketone, which is a widely used chemical raw material and meets the development requirements of green chemistry. In addition, the alpha, beta-unsaturated ketone is a new alkylidenating agent for diaryl methane compounds, is stable, has flexible and changeable structure, has excellent utility in the construction of a multi-substituted olefin compound library, and greatly improves the yield of the tri-substituted ethylene product.

The present invention relates to a carbonyl reductase mutant and its application in the stereoselective synthesis of aromatic multi-substituted chiral γ-butyrolactone. The carbonyl reductase mutant is a protein derived from carbonyl reductase SsCR, whose amino acid sequence is substituted, deleted or added with several amino acids as shown in SEQ ID No.2 and can catalyze the asymmetric reduction of aromatic α- / β-unsaturated ketoesters, and whose catalytic activity is higher than that of carbonyl reductase SsCR, wherein the amino acid sequence of carbonyl reductase SsCR is shown in SEQ ID No.2. The present invention also provides a gene encoding the carbonyl reductase mutant, a recombinant expression vector and a recombinant expression transformant containing the gene, and the application of the carbonyl reductase mutant in the synthesis of chiral aromatic multi-substituted γ-butyrolactone. Compared with the prior art, the present invention has the significant advantages of simple process, high atom economy, high product optical purity and environmental friendliness, and has good industrial application prospects.

Described herein are compounds including at least one β-thio carbonyl or nitrile moiety capable of liberating an active molecule selected from an α,β-unsaturated ketone, aldehyde or nitrile. Also described herein are methods of using said compounds in perfumery as well as perfuming compositions or perfumed articles including the compounds. The compounds are represented by formula (I) where: a) m represents an integer from 1 to 6; b) Pro represents a hydrogen atom or a group susceptible of generating an odoriferous α,β-unsaturated ketone, aldehyde or nitrile and is represented by the formulae (II) or (II′) in which the wavy line indicates the location of the bond between said Pro and the sulfur atom S; and at least one of the Pro groups is of the formula (II) or (II′).

The invention relates to a green and efficient preparation method and application of beta-carbonyl nitrile. The invention belongs to the technical field of fine chemical synthesis. The invention aims to solve the technical problems that the existing method for synthesizing beta-carbonyl nitrile needs to use a large amount of organic solvent and the catalyst is difficult to recover. According to the method, alpha, beta-unsaturated ketone is taken as a substrate, acetone cyanohydrin is taken as a cyaniding reagent, and beta-carbonyl nitrile is synthesized under the action of ionic liquid. According to the method disclosed by the invention, alpha, beta-unsaturated ketone is taken as a raw material, low-toxicity and low-price acetone cyanohydrin is taken as a cyanogen source, beta-carbonyl nitrile can be efficiently synthesized at room temperature without tedious anhydrous and anaerobic operation under the action of green, pollution-free and recyclable ionic liquid, and beta-carbonyl nitrile can be obtained by selecting the ionic liquid. And meanwhile, the ratio of the substances is reasonably controlled in a synergistic manner, so that the side reaction is inhibited to the maximum extent, the efficient synthesis of the high-purity beta-carbonyl nitrile is realized, and the industrial production process of the beta-carbonyl nitrile is promoted.

The invention discloses a green and efficient preparation method of polysubstituted-2-cyanopyrrole, and belongs to the technical field of fine chemical synthesis, according to the method, alpha, beta-unsaturated ketone is taken as a substrate, acetone cyanohydrin is taken as a cyaniding reagent, ionic liquid is taken as alkali and a reaction solvent, and the polysubstituted-2-cyanopyrrole is synthesized at a certain temperature. The structural general formula of the prepared polysubstituted-2-cyanopyrrole is as shown in formula I, in the formula, R1 represents pheyl, thiophen, pyridine, 4-Me-pheyl, 4-OMe-pheyl, 2-Cl-pheyl, 3-Cl-pheyl, 4-Cl-pheyl, 4-CN-pheyl, 4-NO2-pheyl or nanthyl, R2 represents phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, r2 represents Me or Et; r3 represents Me, Et or n-Pr; the raw materials used in the method are cheap and easy to obtain, the green, pollution-free and recoverable ionic liquid is adopted as alkali and a solvent, a volatile organic solvent does not need to be additionally added, the experimental operation is simple, the method is green and environment-friendly, the reaction time is short, the yield is high, and the application range of a substrate is wide.

The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.

The present invention discloses a chiral pyridine-pyrroloimidazolinone tridentate nitrogen ligand and its application in Michael addition reactions, belonging to the field of asymmetric catalysis technology in organic chemistry. Using trans-3-substituted-L-prolinamide and pyridine-2,6-dicarboxaldehyde as raw materials, a chiral pyridine-pyrroloimidazolinone tridentate nitrogen ligand is obtained through a one-step condensation. Using a Lewis acid and the ligand as catalysts, the asymmetric Michael addition reaction of 4-hydroxycoumarin with β,γ-unsaturated α-ketoesters, at dosages as low as 0.05%, achieves high yields and excellent enantioselectivity. The present invention features a novel ligand structure, a simple synthesis method, and extremely low catalyst usage.