42 results about "Unsaturated ketone" patented technology

The invention belongs to the technical field of preparation of transition metal organic photocatalysts, and particularly relates to design and a preparation method of a carbazole terpyridyl nickel catalyst. The invention aims to design and synthesize a carbazole terpyridyl nickel catalyst with light / nickel synergistic catalytic activity. The preparation method comprises the following specific synthesis steps: reacting different types of alpha-pyridone pyridinium and alpha, beta-unsaturated ketone in methanol, and carrying out suction filtration, washing, drying and other operations to obtain the corresponding carbazole terpyridyl ligand. The carbazole terpyridyl ligand and anhydrous nickel bromide are subjected to a heating reflux reaction in a tetrahydrofuran solution, and the corresponding carbazole terpyridyl nickel catalyst is obtained through methanol washing, suction filtration, drying and other operations. The terpyridyl nickel catalyst has high catalytic activity in a C-N, C-O and C-S coupling reaction promoted by visible light.

The invention discloses herbicidal activity application of unsaturated keto ester compounds, and belongs to the technical field of organic pesticides. The alkylamino-containing unsaturated keto ester compound can be used as an effective component for preparing a herbicide, and the prepared herbicide has a relatively good weed growth inhibition effect, is safe to commercial crops such as tomatoes, radishes and lettuce, and has a wide application prospect.

Multiphase polymers comprising crosslinking monomers and polyfunctional amine are disclosed. The multiphase polymer comprises a first phase polymer having a Tg from 60° C. to 240° C., a second phase polymer having a Tg from 40° C. to 240° C., and a soft phase polymer having a Tg from −25° C. to 30° C. The crosslinking monomers include a triacrylate such as trimethylol propane triacrylate, an unsaturated alkoxysilane, and an unsaturated keto monomer reactive with the polyfunctional amine. In contrast to conventional knowledge, incorporation of trimethylolpropane triacrylate reduces the minimum film forming temperature of multiphase polymers. This unusual reduction in MFFT helps to reduce the VOC requirement to form a good film at low VOC. The other crosslinking monomers including unsaturated alkoxy silane and unsaturated keto monomer which react with the polyfunctional amine improve print resistance, block resistance and lower the tackiness of paint films. The multiphase polymer is particularly suitable for use in deep base paints.

This invention provides a 1,3,5-triarylbenzene compound and its preparation method, which involves uniformly mixing α,β-unsaturated ketones, 2-phenylpropanal, and elemental iodine, followed by heating to react, thereby obtaining the compound. Compared with existing technologies, this invention has the following advantages: the reaction conditions are mild, the method is simple and rapid, and the substrate applicability is wide, which is beneficial for industrial production. Furthermore, the structure of the prepared 1,3,5-triarylbenzene compound is more complex and diverse.

The application relates to the technical field of chemical synthesis, and particularly discloses a method for constructing cycloalkanol by nickel-catalyzed asymmetric hydrogenation of tri-substituted enone, and a chiral alcohol prepared by the method. The method uses alpha, beta-unsaturated ketone with different molecular structures as a substrate to construct chiral alcohol with double chiral centers, hydrogen is added to reduce the enyl group first, and then hydrogen is added to reduce the carbonyl group. In the case that the hydrogen on the carbon in the conjugated ring is replaced by different substituents, good reduction effect can be obtained. The catalyst has simple preparation mode and stable performance, and good chiral selection effect and conversion rate can still be obtained under the condition of high substrate / catalyst.

This invention relates to the field of camel thorn separation and purification technology, specifically to unsaturated ketone components from camel thorn, their separation and extraction methods, and their applications. The unsaturated ketone component in camel thorn is (7S,3E,5Z)-7,8-dihydroxy-6-methylocta-3,5-dien-2-one. This invention discloses for the first time the unsaturated ketone components in camel thorn, and in vitro antitumor pharmacodynamic experiments were conducted on these components. The experiments showed that the unsaturated ketone components in camel thorn have a certain inhibitory effect on human HeLa cervical cancer cells, thus enabling their application in the preparation of drugs for the prevention / treatment of cervical cancer.

The invention discloses a method for preparing gamma, delta-unsaturated ketone by using oxalic acid and a mixed acid catalyst thereof. The invention provides a preparation method of a compound as shown in a formula I. The preparation method comprises the following steps: a compound as shown in a formula II and a compound as shown in a formula III are subjected to ketonization reaction at 90-120 DEG C in the presence of a catalyst to generate the compound as shown in the formula I. R1 is C1-C3 alkyl, R2 is C1-C16 alkyl or C2-C16 alkenyl; the catalyst is oxalic acid or mixed acid of oxalic acid and acid A; the acid A is selected from one or more of phosphorous acid, phosphoric acid, alkyl sulfonic acid or aryl sulfonic acid; in the mixed acid, the molar percentage content of the oxalic acid is greater than 50%. According to the preparation method, the reaction selectivity can be improved, and side reactions and high-boiling raffinate are reduced; the catalyst is low in cost, and the reaction system is high in yield. The preparation method disclosed by the invention is simple and convenient to operate, low in cost, green and environment-friendly.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to four kinds of DC-Rhoin analogues, which comprise at least two of a benzoheterocycle, a double bond in a heterocycle and an alpha, beta-unsaturated ketone structure of the double bond and a sulfonyl group, and a preparation method thereof is as follows: 3-acetylinde and triethylamine are sequentially added into a reaction bottle containing 1,2-dichloroethane, the reactants are added under ice bath, after normal temperature reaction, EtOAc and HCl are added for extraction; the organic phase is treated with saturated brine and anhydrous sodium sulfate, concentrated under reduced pressure and separated and purified through a silica gel column, and the DC-Rhoin analogue is obtained. The DC-Rhoin analogue can be used as a lead compound for preparing a RhoA inhibitor.

This invention relates to the synthesis of carboxyl-terminated diunsaturated ketones with C=C double bonds at the α,β and γ,δ positions relative to the carbonyl carbon atom, or the β,γ and γ,δ positions. These ketones can be readily obtained from corresponding alkynyl alcohols with terminal carboxyl groups in a few steps. These ketones are important key building blocks for the synthesis of isoprene-like derivatives, especially vitamin E derivatives.

The application belongs to the technical field of organic chemistry, and particularly relates to a synthesis method of tri-substituted ethylene based on an alkyliden transfer strategy. The synthesis method comprises that, in the presence of an alkali or rare earth complex catalyst, a double (hetero) aryl methane or aryl heteroaryl methane and an alpha, beta-unsaturated ketone are subjected to an alkyliden transfer reaction in an organic solvent to form a corresponding tri-substituted ethylene product. The method has the advantages of small catalyst consumption, mild conditions, no additional additives, easy-to-obtain raw materials, strong reaction universality, simple operation, no salt-type waste, and only one organic by-product, i.e., a ketone, which is a widely used chemical raw material and meets the development requirements of green chemistry. In addition, the alpha, beta-unsaturated ketone is a new alkylidenating agent for diaryl methane compounds, is stable, has flexible and changeable structure, has excellent utility in the construction of a multi-substituted olefin compound library, and greatly improves the yield of the tri-substituted ethylene product.

Described herein are compounds including at least one β-thio carbonyl or nitrile moiety capable of liberating an active molecule selected from an α,β-unsaturated ketone, aldehyde or nitrile. Also described herein are methods of using said compounds in perfumery as well as perfuming compositions or perfumed articles including the compounds. The compounds are represented by formula (I) where: a) m represents an integer from 1 to 6; b) Pro represents a hydrogen atom or a group susceptible of generating an odoriferous α,β-unsaturated ketone, aldehyde or nitrile and is represented by the formulae (II) or (II′) in which the wavy line indicates the location of the bond between said Pro and the sulfur atom S; and at least one of the Pro groups is of the formula (II) or (II′).

The invention discloses a green and efficient preparation method of polysubstituted-2-cyanopyrrole, and belongs to the technical field of fine chemical synthesis, according to the method, alpha, beta-unsaturated ketone is taken as a substrate, acetone cyanohydrin is taken as a cyaniding reagent, ionic liquid is taken as alkali and a reaction solvent, and the polysubstituted-2-cyanopyrrole is synthesized at a certain temperature. The structural general formula of the prepared polysubstituted-2-cyanopyrrole is as shown in formula I, in the formula, R1 represents pheyl, thiophen, pyridine, 4-Me-pheyl, 4-OMe-pheyl, 2-Cl-pheyl, 3-Cl-pheyl, 4-Cl-pheyl, 4-CN-pheyl, 4-NO2-pheyl or nanthyl, R2 represents phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, phenyl, r2 represents Me or Et; r3 represents Me, Et or n-Pr; the raw materials used in the method are cheap and easy to obtain, the green, pollution-free and recoverable ionic liquid is adopted as alkali and a solvent, a volatile organic solvent does not need to be additionally added, the experimental operation is simple, the method is green and environment-friendly, the reaction time is short, the yield is high, and the application range of a substrate is wide.

The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.

The invention discloses an eight-membered cyclic alpha, beta-unsaturated ketone solalyratin B as well as a preparation method and application thereof, and belongs to the technical field of natural product chemistry and plant active ingredient extraction, and the structural formula of the eight-membered cyclic alpha, beta-unsaturated ketone solalyratin B is shown in the specification. The invention also relates to an application of the eight-membered cyclic alpha, beta-unsaturated ketone solyratin B in preparation of an antioxidant or antibacterial active preparation. The invention provides an efficient eight-membered ring alpha, beta-unsaturated ketone solyratin B separation method, the separation efficiency and the product purity are improved, meanwhile, the operation process is simplified, and the accuracy of structural identification is ensured.

The invention provides a bicycloacetylene alcohol compound which is characterized in that a hydroxyl-substituted carbon atom in the compound is a three-stage carbon atom bonded with an acetylene group, and alpha carbon in the compound is bridgehead carbon or no hydrogen atom exists on the alpha carbon, or both are satisfied. As a result, it is possible to provide: a bicycloacetylene alcohol compound which is not susceptible to initiating an isomerization reaction formed into an alpha, beta-unsaturated ketone; and an addition-curable silicone composition and a thermally conductive addition-curable silicone composition which contain said compound.

The application discloses functions and uses of a kind of pentacyclic triterpenoid compounds in preventing and / or treating neurodegenerative diseases, and the compounds are obtained by isolating and extracting from Cynomorium songaricum Rupr medicinal materials.The inventors found that the compounds have significant protective effects on glutamic acid-induced nerve cell injury and oxygen-glucose deprivation-induced nerve cell injury during pharmacological activity evaluation of the compounds, and thus can be used for treating and preventing neurodegenerative diseases such as stroke, brain injury, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Alzheimer's disease, and can be developed into drugs.

The invention relates to the technical field of chemical synthesis, in particular to a polycyclic spiropyrrolidine compound and a preparation method thereof. The polycyclic spiropyrrolidine compound is prepared by carrying out two-component 1, 3-dipolar cycloaddition reaction on alpha, beta-unsaturated ketone substituted by different substituent groups and (E)-1-methyl-3-(3, 3, 3-trifluoropropylidene) indoline-2-ketone in an organic solvent under the catalytic action of a basic catalyst, the synthesis method is simple, the applicability is wide, and the preparation method is suitable for industrial production. The method can be carried out in a plurality of organic solvents, has good compatibility with a plurality of substituent groups, and has good air stability. The polycyclic spiropyrrolidine compound provided by the invention contains a spiropyrrolidine skeleton with potential biological activity, can provide a compound source for biological activity screening, and has important application value in the field of pharmacy.

This invention discloses a method for the green catalytic synthesis of γ-ketophosphine oxides from asymmetric alkylaluminum compounds under mild conditions. Using phosphine oxides as raw materials and an asymmetric alkylaluminum compound as a catalyst, the reaction proceeds with α,β-unsaturated ketones in the range of 60°C to 100°C and in the presence of an organic solvent to generate γ-ketophosphine oxides. This method features mild reaction conditions, high product yield, broad substrate scope, and the absence of added acids, bases, and heavy metals, thus meeting the requirements of green chemistry and atom-economical reactions.

The invention relates to the fields of coordination chemistry and metal organic chemistry, and discloses a metal-only center chiral osmium carbon dragon complex as well as a preparation method and application thereof. According to the synthesis method, a chiral polyalkyne carbon chain (a carbon dragon ligand precursor containing a propargyl alcohol structure unit) with pure enantiomers is reacted with a metal osmium source OsCl2 (PAr3) 3, and the chirality of a carbon center on the polyalkyne carbon chain is transferred to the chirality of a metal center of the carbon dragon complex through a chiral transfer strategy, so that the one-pot preparation of the metal-center-only chiral osmium carbon dragon complex is realized. The synthesis method has the characteristics of simplicity and convenience in operation, easiness in separation, mild reaction conditions, easiness in obtaining of raw materials, good universality of reactants and the like. And meanwhile, the obtained metal-center-only chiral osmium carbon long complex can react with various reagents such as m-chloroperoxybenzoic acid / sulfur powder / tin powder / cuprous chloride / silver tetrafluoroborate, phenanthroline / triphenylphosphine gold chloride / acetonitrile / pyridine / imidazole and the like, so that further derivatization is realized, and a series of brand new metal-center-only chiral osmium carbon long complexes are obtained. The metal-only center chiral osmium-penta-oxa three-membered ring complex provided by the invention can be used for efficiently catalyzing an asymmetric Michael addition reaction of indole and an alpha-hydroxyl-alpha ', beta'-unsaturated ketone compound.

The application discloses a novel and efficient electrochemical catalytic synthesis of sulfone isoxazole derivatives. The method uses beta, gamma-unsaturated ketone oxime and p-toluenesulfonyl hydrazine as starting materials, under the condition of C(+) / C(-) as an electrode, a current of 10 mA, and reaction at room temperature for 4 h, the oxidation sulfonation reaction of the alkenyl oxime substrate can be smoothly realized, and sulfone isoxazole derivatives are obtained. The sulfone radical is generated by anodic single electron oxidation of p-toluenesulfonyl hydrazine, then the radical addition is carried out on the alkenyl oxime, the benzyl radical is generated, then the radical oxidation reaction of the benzyl position and the intramolecular nucleophilic cyclization reaction are further carried out at the anode to generate the sulfone isoxazole product. Compared with the traditional synthesis scheme, the application only needs to add inorganic electrolyte as a conductive medium under mild conditions, without the addition of metal and additional oxidants, and the sulfone group can be introduced into the skeleton of the isoxazole ring under the electrochemical condition, and the aryl alkyl sulfone compound constructed is widely used in medicines, biologically active products and materials, and has important biological and synthetic research value.

A method for the manufacture of an α,β-unsaturated ketone, which method comprises oxidizing an alkene having —CH2— adjacent a carbon-carbon double bond to α,β-unsaturated ketone by passing air or oxygen through a solution of the hydrocarbon containing a catalyst consisting of N-hydroxyphthalimide (NHPI) and cobalt diacetate tetrahydrate at standard temperature and pressure during a period of at least 12 hours.

This invention discloses 6,20-epoxy A-ring modified derivatives of oridonin, their preparation methods, and uses, belonging to the field of natural medicine and medicinal chemistry. Using oridonin as a lead compound, this invention designed and synthesized a series of 6,20-epoxy oridonin derivatives with α,β-unsaturated ketones introduced into the A ring. The antitumor activity of the synthesized derivatives was tested. The results showed that the oridonin derivatives prepared in this invention exhibited good antitumor activity against various tumor cells (human breast cancer cells MCF-7, human lung adenocarcinoma cells A549, human liver cancer cells Bel-7402, human liver cancer cells HepG2, human pancreatic cancer cells Panc-1, and MIA-PaCa-2), demonstrating potential as anticancer drugs.

The invention belongs to the field of organic chemistry, and particularly relates to a preparation method of gamma, delta-unsaturated ketone by adopting a continuous flow process. According to the present invention, the existing Karol rearrangement reaction is improved, and the gamma, delta-unsaturated ketone preparation method using the continuous flow process is provided, and is successfully used in the synthesis of farnesyl acetone and teprenone. The preparation method disclosed by the invention can be safely, rapidly and continuously carried out at high temperature and high pressure, greatly improves the reaction efficiency, reduces unnecessary heat energy loss, and is green, environment-friendly, economical and more suitable for industrial production.

The invention discloses a method for preparing gamma, delta-unsaturated ketone by using an organic acid-nitrogenous alkali composite catalytic system. The invention provides a preparation method of a compound as shown in a formula I. The preparation method comprises the following step: reacting a compound as shown in a formula II with a compound as shown in a formula III to generate the compound as shown in the formula I under the action of organic acid and nitrogen-containing alkali. The preparation method provided by the invention can effectively inhibit the generation of conjugated diene by-products by dehydration, and significantly improve the selectivity and yield of target products.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of an allyl alcohol compound, which adopts commercially available cheap sodium triethylborohydride and / or lithium triethylborohydride as a catalyst and alpha, beta-unsaturated ketone / aldehyde as a substrate, thereby avoiding the use of toxic heavy metals and expensive metal catalysts / complexing agents. According to the present invention, the reaction conditions are mild (the reaction can be efficiently performed at the room temperature), the experiment operation and the post-treatment steps are simple, and the prepared allyl alcohol compound has characteristics of high yield, high selectivity and high turnover frequency (TOF), and has the selectivity and the yield significantly superior to the selectivity and the yield of the allyl alcohol compound prepared by using the traditional preparation method; the substrate is wide in application range, and shows excellent tolerance to functional groups such as nitro, cyano, ester group, amino, halogen, alkoxy, aryl and heteroaryl.

The invention relates to the technical field of organic synthesis and medicines, in particular to a verbenone-based alpha, beta-unsaturated ketone derivative and a synthesis method and application thereof.The synthesis method includes the steps that condensation reaction is conducted on verbenone and benzaldehyde compounds, and under the alkaline condition of sodium hydroxide, the verbenone-based alpha, beta-unsaturated ketone derivative is synthesized at the high yield of 83% or above; the target derivative c1-c10 is obtained by adding a beta, beta-unsaturated ketone derivative to the target derivative c1-c10. The verbenone keto alpha, beta-unsaturated ketone derivative disclosed by the invention has the main advantages that the series of products are cheap and easily available in raw materials, novel in structure, high in yield, simple in separation and purification operation and suitable for mass production, all the products show relatively good biological activity, and detection shows that IC50 of the derivative c9 to non-small cell lung cancer A549 is 7.16 uM.

The invention belongs to the field of synthesis of quinoline / isoquinoline compounds, and particularly discloses a quinoline compound or an isoquinoline compound as well as a synthesis method and application thereof. According to the method disclosed by the invention, the acetophenone compound, the alpha, beta-unsaturated ketone compound and the hydroxylamine sulfonic acid are used as raw materials, the quinoline compound and / or the isoquinoline compound are / is efficiently and highly selectively synthesized in the presence of the catalyst, the oxidizing agent, the additive and the solvent, and the yield is relatively high. The preparation method disclosed by the invention is mild in condition, simple in step, high in selectivity, environment-friendly and wide in functional group compatibility, has extremely high scientific value and industrial application prospect, and is proved to be used for efficiently synthesizing the rosaxostat.

The application discloses a preparation method of a novel aluminum hydrogen compound and a preparation method of unsaturated alcohol compounds catalyzed by the aluminum hydrogen compound. The preparation method is as follows: first, 1-phenyl-1,3-butanedione and 2,6-diisopropylaniline are condensed to form a ligand, then the ligand is reacted with 0.5 equivalent of trihydroaluminum trimethylamine to form the novel aluminum hydrogen compound. Subsequently, the aluminum hydrogen compound is used as a catalyst to catalyze the reaction of unsaturated ketone compounds and boron hydride compounds and hydrolysis to obtain corresponding unsaturated alcohol compounds. The preparation method is simple, the synthesized aluminum hydrogen compound has a remarkable effect in the boron hydride reaction of unsaturated ketones, the catalyst is only applicable to 5%, the reaction speed is fast and the yield is high, the problems of high price of the catalyst used in the preparation method of the unsaturated alcohol compounds and the need of high-pressure hydrogen are solved, and the concept of green chemistry is met.

The invention belongs to the field of organic synthesis, and discloses a method for synthesizing unsaturated ketone, which comprises the following steps: in the presence of a composite catalyst, catalyzing unsaturated alcohol and alkyl acetoacetate to carry out Carroll reaction, and then carrying out post-treatment to obtain the unsaturated ketone. According to the method, the novel composite catalyst is adopted to replace a traditional basic catalyst, so that the problems of equipment corrosion and incapability of mechanical application caused by the traditional basic catalyst are solved, meanwhile, the selectivity and the yield of the reaction are improved, and industrial mass production of unsaturated ketone is facilitated.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a method for N-alpha site disubstitution of an enamine compound through light palladium concerted catalysis. Under the action of a composite catalyst, an enamine compound and an unsaturated ketone compound are promoted to react, and the composite catalyst is formed by mixing a visible light catalyst and a metal catalyst. The photocatalyst has the advantages that the reaction process is safe and controllable, and the preparation and production operation is simplified; a Kessil lamp is used as a reaction light source, is safe and environment-friendly, has high energy utilization efficiency, and can efficiently realize conversion from light energy to chemical energy; the used raw materials are low in price and easy to obtain, and the preparation process is simple. The process conditions are mild, the regioselectivity is good, the N-alpha-position disubstituted product can be efficiently obtained only through one-step reaction, and the designability and application prospects of the compounds are greatly expanded.