3 results about "Isovanillin" patented technology

The invention discloses a supported bimetallic complex catalyst for synthesizing isovanillin and a preparation method and application thereof.The catalyst is composed of an inorganic porous carrier and an active component supported on the inorganic porous carrier, and the active component is a bimetallic complex formed by Cu, Co and 1, 10-phenanthroline; the inorganic porous carrier is an SBA-15 molecular sieve or amino-modified Fe3O4 (at) SiO2 magnetic nanoparticles with a core-shell structure. The catalyst is prepared from a metal salt, a ligand and a carrier in a solvent through a coordination-loading one-step method. The catalyst disclosed by the invention is applied to one-step synthesis reaction of isovanillin by taking heliotropin and sodium methoxide or potassium methoxide as raw materials, and shows extremely high catalytic activity and product selectivity (yield gt; and by virtue of the load-type characteristic, especially the application of the magnetic carrier, rapid magnetic separation and recovery and repeated recycling can be realized, so that the catalyst is obviously superior to a traditional homogeneous copper chloride catalytic system, and has the potential of simple steps, environment friendliness and suitability for industrial production.

This invention discloses a highly selective synthesis method for isovlandrin, comprising the following steps: Step S1, reacting guaiacol with a benzylating agent in the presence of an alkaline catalyst and an organic solvent to generate o-benzyloxyanisole; Step S2, reacting the o-benzyloxyanisole with a Vilsmeier-Haack reagent for formylation to obtain 3-benzyloxy-4-methoxybenzaldehyde; Step S3, mixing 3-benzyloxy-4-methoxybenzaldehyde with a 65wt%-70wt% aqueous sulfuric acid solution to perform an acid debenzylation reaction to obtain crude isovlandrin; Compared with the prior art, the yield of isovlandrin can reach up to 70% or more, and the selectivity is greatly improved.

The application belongs to the technical field of traditional Chinese medicine detection, and specifically provides a construction method and a quality detection method for characteristic chromatograms of Sarcandra glabra medicinal preparation, wherein octadecylsilane bonded silica gel is used as a filler, acetonitrile is used as mobile phase A, and a water solution containing potassium dihydrogen phosphate is used as mobile phase B, a gradient elution program is continuously optimized, the column temperature is controlled to be 23-27 DEG C, 11 common characteristic peaks are finally obtained, 9 common characteristic peaks are effectively separated, the characteristic chromatogram obtained has a smooth baseline, the characteristic peaks have good peak shapes, and the detection time is short, thereby providing a scientific basis for comprehensively establishing the quality control standard of Sarcandra glabra formula granules. Moreover, the peak positions of tryptophan, syringin, isovanillin and magnoflorine can be accurately positioned, the known information of the characteristic peaks is increased, and the integrity and characteristics of Sarcandra glabra medicinal preparation (for example, formula granules and other preparations) are fully reflected.