10 results about "Isovanillin" patented technology

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly provides a construction method and a quality detection method of a specific chromatogram of a tinospora sinensis merr medicinal preparation, octadecylsilane chemically bonded silica is used as a filler, acetonitrile is used as a mobile phase A, an aqueous solution containing monopotassium phosphate is used as a mobile phase B, and a gradient elution procedure is continuously optimized; according to the method, the column temperature is controlled to be 23-27 DEG C, 11 common characteristic peaks are finally obtained, effective separation of 9 common characteristic peaks is achieved, the obtained characteristic chromatogram is stable in base line, good in characteristic peak shape and short in detection time, and a scientific basis is provided for comprehensively establishing the quality control standard of the tinospora sinensis merr formula granules. And moreover, the peak positions of tryptophan, syringin, isovanillin and magnoflorine can be accurately positioned, the known information of characteristic peaks is increased, and the integrity and characteristics of the tinospora sinensis merr medicinal preparations (such as preparations such as formula granules) are fully reflected.

The invention discloses a supported bimetallic complex catalyst for synthesizing isovanillin and a preparation method and application thereof.The catalyst is composed of an inorganic porous carrier and an active component supported on the inorganic porous carrier, and the active component is a bimetallic complex formed by Cu, Co and 1, 10-phenanthroline; the inorganic porous carrier is an SBA-15 molecular sieve or amino-modified Fe3O4 (at) SiO2 magnetic nanoparticles with a core-shell structure. The catalyst is prepared from a metal salt, a ligand and a carrier in a solvent through a coordination-loading one-step method. The catalyst disclosed by the invention is applied to one-step synthesis reaction of isovanillin by taking heliotropin and sodium methoxide or potassium methoxide as raw materials, and shows extremely high catalytic activity and product selectivity (yield gt; and by virtue of the load-type characteristic, especially the application of the magnetic carrier, rapid magnetic separation and recovery and repeated recycling can be realized, so that the catalyst is obviously superior to a traditional homogeneous copper chloride catalytic system, and has the potential of simple steps, environment friendliness and suitability for industrial production.

This invention discloses a highly selective synthesis method for isovlandrin, comprising the following steps: Step S1, reacting guaiacol with a benzylating agent in the presence of an alkaline catalyst and an organic solvent to generate o-benzyloxyanisole; Step S2, reacting the o-benzyloxyanisole with a Vilsmeier-Haack reagent for formylation to obtain 3-benzyloxy-4-methoxybenzaldehyde; Step S3, mixing 3-benzyloxy-4-methoxybenzaldehyde with a 65wt%-70wt% aqueous sulfuric acid solution to perform an acid debenzylation reaction to obtain crude isovlandrin; Compared with the prior art, the yield of isovlandrin can reach up to 70% or more, and the selectivity is greatly improved.

Multiple active component therapeutic formulations are described comprising at least two active agents selected from the group consisting of an isovanillin component, a harmine component, and a curcumin component, stabilized in a self-supporting lipid crystalline formulation for topical application. The formulation maintains the active agents in a stable form during storage and will melt at body temperature when applied to the skin, wherein the lipid crystals melt into a liquid crystalline structure thereby releasing the active agents to the applied area of the skin or tissue to render their therapeutic effect.

Human therapeutic treatment compositions comprising a curcumin component, a harmine component, and an isovanillin component, preferably all three in combination. The agents are synergistically effective for treatment of human conditions, especially human cancers, such as pancreatic cancers.

The present invention relates to the technical field of medicinal chemistry, and discloses a jatrorrhizine derivative with antibacterial activity, a synthesis method and an application. Starting from isovanillin, the present invention simply and efficiently synthesizes a series of novel 3-alkyl / acyl jatrorrhizine derivatives through Henry reaction, reduction reaction, Pictet-Spengler reaction, reductive amination, Friedel-Crafts cyclization and nucleophilic substitution reaction. R in the structural formula of this type of derivative is an aliphatic or aromatic hydrocarbon group, acyl group, cinnamoyl group or triazole with C2- 12 The antibacterial activity of 3-decyloxy jatrorrhizine is excellent, the cytotoxicity is small, and the relative safety is large, and it can be further developed into a potential drug for anti-Gram-positive bacterial infection. 3-Aromatic acyloxy jatrorrhizine shows good inhibitory activity against Helicobacter pylori.

The invention relates to the technical field of compound synthesis, in particular to a preparation method of an Advantame intermediate 3-hydroxy-4-methoxy phenylpropanal, which comprises the following steps: mixing deionized water with a basic catalyst; the preparation method comprises the following steps: adding isovanillin into an alkaline substrate solution, fully dissolving the isovanillin, reducing the temperature of the alkaline solution to 9-12 DEG C, slowly adding a predetermined amount of vinyl acetate, dropwise adding the vinyl acetate within 5-6 hours, and continuously stirring and reacting for 30-60 minutes at the temperature of 9-12 DEG C; dropwise adding an acidic solution into the reaction mixture, drying a filter cake, adding ethanol, and recrystallizing to obtain 3-hydroxy-4-methoxycinnamaldehyde; the method comprises the following steps: adding 3-hydroxy-4-methoxycinnamyl aldehyde into a hydrogenation reaction kettle, adding a 10% palladium carbon catalyst, controlling the kettle temperature to be 10-30 DEG C, and controlling the hydrogen introduction pressure to be 0.6-0.8 mpa until the pressure in the reaction kettle is not reduced any more, thereby obtaining the 3-hydroxy-4-methoxyphenylpropanal.

The application belongs to the technical field of traditional Chinese medicine detection, and specifically provides a construction method and a quality detection method for characteristic chromatograms of Sarcandra glabra medicinal preparation, wherein octadecylsilane bonded silica gel is used as a filler, acetonitrile is used as mobile phase A, and a water solution containing potassium dihydrogen phosphate is used as mobile phase B, a gradient elution program is continuously optimized, the column temperature is controlled to be 23-27 DEG C, 11 common characteristic peaks are finally obtained, 9 common characteristic peaks are effectively separated, the characteristic chromatogram obtained has a smooth baseline, the characteristic peaks have good peak shapes, and the detection time is short, thereby providing a scientific basis for comprehensively establishing the quality control standard of Sarcandra glabra formula granules. Moreover, the peak positions of tryptophan, syringin, isovanillin and magnoflorine can be accurately positioned, the known information of the characteristic peaks is increased, and the integrity and characteristics of Sarcandra glabra medicinal preparation (for example, formula granules and other preparations) are fully reflected.

The present invention discloses an opioid derivative, an intermediate thereof and a preparation method thereof. The present invention provides a preparation method of a compound represented by formula A6. The preparation method comprises the following step S7: under the action of a palladium catalyst, a phosphine ligand represented by formula L1 and a base, carrying out the dearomatization cyclization reaction shown below on the compound represented by formula A5 in an organic solvent to obtain the compound represented by formula A6. By using the synthesis route and intermediate of the present invention, it is possible to prepare opioid compounds starting from cheap and easily available vanillin and isovanillin, providing the possibility for its large-scale production.

The invention provides a tanshinone-based conjugate coupling chromogenic molecule as well as a preparation method and application thereof, and relates to the technical field of analysis and detection of fluid substances. The preparation method of the tanshinone-based conjugate coupling chromogenic molecule comprises the following steps: mixing a tanshinone IIA solution, an organic alkali solution and an isovanillin solution, and carrying out conjugate coupling reaction to obtain the tanshinone-based conjugate coupling chromogenic molecule (HMDTD). HMDTD can present different degrees of rotatable characteristics in different microcell fluid environments and can freely rotate in a low-viscosity liquid object to be detected, the excited state energy is mainly dissipated in a mechanical rotation mode, and a released optical signal is weak; compared with the prior art, rotation in a high-viscosity liquid to-be-measured object is inhibited, excited state energy is mainly dissipated in a radiation transition mode, released optical signals are strong, different optical signal release intensities are presented, and then effective measurement of the viscosity of the micro-area of the liquid to-be-measured object can be achieved.