38 results about "Trityl chloride" patented technology

The invention discloses a preparation method of a folic acid sulfhydrylation derivative. The preparation method comprises the following steps that -SH in thiol is protected to obtain a derivative of thiol, so that sulfydryl having high reaction activity is protected; then, in the presence of a catalyst and a dehydrating agent, esterification reaction is carried out between hydroxyl on the protected thiol derivative and folic acid, so that a modified folic acid derivative is obtained; a carbon sulphur bond in the folic acid derivative is broken through reduction reaction; sulfydryl is formed again in a product, and therefore, the target product, namely sulfhydrylation folic acid, is obtained. According to the preparation method disclosed by the invention, trityl chloride is replaced by triphenylcarbinol; the disadvantages of difficulty in separation of products and lower product yield are overcome; the product yield is increased; in the esterification reaction, a solid catalyst (macroporous cation exchange resin) is adopted, so that the separation efficiency of products is greatly improved; micromolecules, such as 4-dimethylamino-pyridine (DMAP), are adopted in normal biological preparation; the micromolecules are easily dissolved in a solvent and difficult to separate.

The invention provides an asymmetric anionic copolymerization method of a methacrylate chiral polymer. The method comprises the following steps: reacting methacrylic acid with trityl chloride to generate a large-volume triphenylmethyl acrylate monomer, carrying out an asymmetric anionic copolymerization reaction on the large-volume triphenylmethyl acrylate monomer and a self-made chiral function monomer under specific anion conditions to obtain a large-volume methacrylate chiral polymer; and purifying the polymer to finally obtain a target product. The structural characterization and analysis of the obtained polymer are carried out by using nuclear magnetic resonance hydrogen spectrum (<1>H-NMR) and an element analysis technology to determine that the molecular structure of the polymer and proportions of all components of the polymer accord with design requirements. Performances of the synthesized copolymer are deeply analyzed through using a gel permeation chromatograph and a polarimeter to obtain the molecular weight of the novel chiral copolymer and the distribution thereof, and the optical active characteristics of the copolymer. The method has the advantages of clear and feasible synthesis route, manure process, simple operation, easy realization, and large-scale batch production.

The present invention discloses a theasapogenol derivative with anti-tumour activity and preparing method and application thereof. The theasapogenol derivative with anti-tumour activity has a structure shown as formula I; and the preparing method comprises the following steps of: (1) reacting theasapogenol, which is the raw material, with trityl chloride in a pyridine solvent by using 4-dimethylamino pyridine as a catalyst, reacting the reaction product with benzyl bromide, and reacting the product thereof with formic acid to obtain alcohol terpenoid compound; (2) introducing in methylsulfonyl at C-28 bit based on the alcohol terpenoid compound; introducing in cyano at the C-28 bit with NaCN as a cyaniding reagent; and finally removing benzyl at palladium / carbon under hydrogen reduction condition, so as to obtain the theasapogenol derivative with anti-tumour activity shown as formula I. The theasapogenol derivative of the present invention has high anti-tumour activity; the preparing method and process are simple; and the theasapogenol derivative is convenient for industrial production.

The present invention provides a method for asymmetrical free-radicals of methacrylate chiral polymer. The method comprises: firstly performing a reaction on methacrylic acid with trityl chloride to generate a methacrylic acid / trityl chloride monomer in a large volume; then performing asymmetrical free-radical copolymerization on the monomer and a chiral functional monomer under specific free-radical polymerization conditions; and obtaining a methacrylate chiral copolymer in a large volume; and performing purification on the obtained polymer to finally obtain a target product. NMR (1H-NMR) and elemental analytical techonlogies are are used for structural characterization and analysis of the obtained polymer to determine that the molecular structure and the component ratio meet design requirements. Gel permeation chromatography and a polarimeter are used for performing in-depth analysis on performances of the synthesized copolymer to obtain molecular weight and distribution of the new chiral copolymer and features of optical activity. The synthesis route is clear and feasible, the process is sophisticated, the operations are simple, and the method is easy to implement; and the method can be used for large-scale batch production.