28 results about "Pyridinium" patented technology

This invention relates to aggregation-induced emission probes with specific responses to tumor markers and their applications, belonging to the field of biochemistry. This invention utilizes molecular structure modulation to prepare a series of molecules possessing large Stokes shifts, resistance to photobleaching, near-infrared II (NIR-II) emission, and aggregation-induced emission properties. Different self-eliminating groups are attached to the dimethylamino group of the molecule via quaternization or to the pyridine group via pyridinium salting. By controlling the structure of these self-eliminating groups, activatable luminescent probes responding to different tumor markers can be constructed. These probes integrate deep NIR-II imaging, aggregation-point luminescence, large Stokes shifts, and marker-specific responses, providing a new approach for precise imaging diagnosis of tumors.

This invention discloses a double-sided chain extender, its preparation method, and its application in the synthesis of ion-conducting polyurethane. The structure of the double-sided chain extender is shown in Formula I. The double-sided chain extender is prepared by a Michael addition reaction of an acceptor compound and 3-amino-1,2-propanediol. The acceptor compound is selected from one of the following: acrylic acid, 2-acryloylamino-2-methyl-1-propanesulfonic acid, acryloyloxyethyltrimethylammonium chloride, 1-vinyl-3-butylimidazolium chloride, 3-((2-(acryloyloxy)ethyl)dimethylammonium)propane-1-sulfonate, 2-(1-(6-(((2-(acryloyloxy)ethyl)carbamoyl)oxo)hexyl)pyridin-1-onthium-4-yl)ethane-1-sulfonate. This invention provides the application of the double-sided chain extender in the synthesis of ion-conducting polyurethane with excellent mechanical properties and ion transport capabilities. I.

The application provides a static spinning solution containing pyridinium propane sulfonate, a preparation method thereof and a static spinning method thereof. The static spinning solution comprises an additive pyridinium propane sulfonate, PAN polyacrylonitrile and DMF. Experiments prove that the static spinning solution has low cost, can improve the entanglement degree between molecular chains, inhibits the breakage of a solution jet in a static spinning process, and the micro-morphology is improved.

This invention relates to a chiral preparation method for florfenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and synthesizes the key chiral intermediate I through an asymmetric aldol reaction process under the action of a pyridinium salt carbonyl catalyst. Subsequently, through reduction, cyclization, fluorination, and hydrolysis ring-opening reactions, the chiral product florfenicol is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to efficiently control the stereoselectivity of the aldol reaction process, highly selectively constructing the two chiral centers on the florfenicol structure, obtaining the desired chiral configuration, and finally synthesizing florfenicol. The preparation method of this invention is simple, rapid, and efficient.

This invention relates to a chiral preparation method for irushlstat. Specifically, the method uses 2,3-dihydro-1,4-benzodioxyl-6-aldehyde and 2-amino-1-(pyrrolidine-1-yl)ethyl ketone as starting materials, and carries out an asymmetric aldol reaction in the presence of a pyridinium salt carbonyl catalyst. Following reduction and amidation reactions, chiral irushlstat is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to rapidly construct the two key chiral centers of the irushlstat structure with high diastereoselectivity and high enantioselectivity, shortening the synthetic steps of irushlstat. Furthermore, the reaction conditions of this invention are mild and the operation is simple.

To improve electrochromic materials so that they can be used as a transparent medium for forming high-quality articles, especially high-quality eyeglass lenses, while maintaining electrochromic properties and having a wide range of colors. [Solution] The present invention relates to a novel group of electrochromic compounds. More specifically, the present invention relates to benzazole and condensed azole compounds substituted with one or more pyridinium rings, and the use of these compounds as variable transmittance media for the manufacture of optical articles such as spectacle lenses.

This invention relates to a method for preparing chiral drosildopa. Specifically, the method uses compound 1 and glycine ester as starting materials, and an asymmetric aldol reaction occurs under the action of a pyridinium salt carbonyl catalyst, followed by hydrolysis to obtain drosildopa. Compared with the prior art, this invention utilizes the strong catalytic ability of small molecule pyridinium salt carbonyl catalysts, starts with inexpensive and readily available raw materials, reduces the steps of introducing and removing protecting groups, shortens the synthetic route, and efficiently synthesizes optically pure drosildopa. Furthermore, the preparation method of this invention is simple to operate and environmentally friendly.

This invention provides an alkali-generating agent and a curable resin composition that exhibit excellent storage stability in a liquid, high catalytic activity at the desired curing temperature, and induce a curing reaction in a short time. An alkali-generating agent comprises a pyridinium cation and an anionic residue of an organic or inorganic acid, and is represented by the following formula (a). (In formula (a), A represents a divalent hydrocarbon group with 1 to 8 carbon atoms that may contain heteroatoms; R1 to R5 independently represent hydrogen atoms or electron-donating groups; R1 and R2, R2 and R3, R3 and R4, and R4 and R5 can be bonded to form a ring structure. R6 to R5...) 10 Each of the following groups independently represents a hydrogen atom, halogen atom, hydroxyl group, alkoxy group, mercapto group, sulfide group, silyl group, silanol group, nitro group, nitroso group, cyano group, sulfinic acid group, sulfonyl group, sulfonic acid group, phosphono group, oxophosphono group, phosphonyl group, phosphonate group, amino group, or ammonium group, R6 and R7, R7 and R8, R8 and R9, R9 and R 10 They can be bonded separately to form a ring structure.

This invention discloses a triphenylamine-based D-A type AIE molecule targeting STAT3, its preparation method, and its application in the diagnosis and treatment of colorectal cancer. This molecule uses triphenylamine as a donor and pyridinium as an acceptor, linked by a rigid conjugated trans-vinyl group, exhibiting aggregation-induced emission (AIE) properties. The preparation method employs a Knoevenagel condensation reaction, using 4-(diphenylamino)benzaldehyde and 1,4-dimethylpyridinium iodide as raw materials, and proceeds via a nucleophilic addition-dehydration reaction catalyzed by pyrrolidine, with a yield of 50±3% and a purity ≥98%. This molecule exhibits a fluorescence emission wavelength of 640 nm, demonstrates a significant AIE effect, can penetrate the colorectal cancer cell membrane and specifically aggregate, and shows activity against the IC50 of HCT116 and DLD1 cells. 50 The concentrations were 6.41 μM and 11.46 μM, respectively, which exerted anti-tumor effects by inhibiting STAT3 phosphorylation, enabling integrated diagnosis and treatment of colorectal cancer.

Chemical compounds that include a pyridinium-based compound functionalized by including a sulfur-containing substituent are provided. Also provided are materials and formulations including such pyridinium-based compounds. Also provided are corrosion-resistant substrates and films including such pyridinium-based compounds. Also provided are processes for inhibiting corrosion of a metallic surface using the formulations and processes of acidizing a subsurface formation using the pyridinium-based compounds.

The application relates to the technical field of biological medicine, and discloses a preparation method of a liposome with a pH response type membrane fusion effect and application of the liposome. The pyridium betaine-terminated lipid molecule provided by the application can be quickly and reversibly protonated in a weak acid microenvironment of a tumor, the surface charge of the liposome is changed from negative to positive, and the precise switch of the membrane fusion behavior is realized; the self-adaptive fusion liposome constructed based on the pyridium betaine-terminated lipid molecule successfully converts the non-specific toxicity risk of the traditional fusion liposome into a space-limited intelligent response, remains stable and inert in blood circulation (pH=7.4), and specifically activates the membrane fusion at a tumor site, realizes direct cytoplasmic delivery of a drug and avoids lysosome degradation; the STING nano agonist constructed by loading the nano composite of a STING pathway agonist and a divalent metal ion on the platform exhibits a strong pH-dependent anti-tumor immune activation effect in vitro and in vivo, and significantly inhibits tumor growth while the systemic toxicity is extremely low.

A composition having a breaking strength of 10.0 N or more, containing a polytetrafluoroethylene, and substantially free from a compound represented by the following General Formula (3): (H—(CF2)8—SO3)qM2, wherein M2 is H, a metal atom, NR54, where each R5 may be the same or different and is H or an organic group having 1 to 10 carbon atoms, imidazolium optionally having a substituent, pyridinium optionally having a substituent, or phosphonium optionally having a substituent; and q is 1 or 2.

This invention discloses a hydrophobic drug delivery nanoparticle, its preparation method, and its application, belonging to the field of biomedical technology. The method includes the following steps: (1) preparing a hydrophobic drug organic solution and a 4-(2-(5-(4-(diphenylamino)phenyl)thiophene)vinyl)-1-(3-(trimethylammonium)propyl)pyridine-1-onium bromide TTVP organic solution, mixing them, and removing the organic solvent to obtain a hydrophobic drug-TTVP complex; (2) mixing the hydrophobic drug-TTVP complex with a nucleic acid aqueous solution, and performing heat treatment by programmed temperature control to allow the hydrophobic drug, TTVP, and nucleic acid to self-assemble into nanoparticles, and further centrifuging and washing to obtain the hydrophobic drug delivery nanoparticles. The method of this invention is environmentally friendly, simple in steps, and has high drug loading efficiency. It can be used as a universal hydrophobic drug delivery system to achieve efficient diagnosis and treatment of diseases.

This invention belongs to the field of functional coating technology, specifically relating to an electrolyte for electrodeposition preparation of FeCoNiCu high-entropy alloy coatings and its application. The electrolyte includes FeSO4·7H2O, CoSO4·7H2O, NiSO4·6H2O, CuSO4·5H2O, H3BO3, sodium citrate, citric acid, NaCl, and additives. The additives are selected from at least one of o-phenanthroline, o-chlorobenzaldehyde, potassium thiocyanate, sodium 3-mercapto-1-propanesulfonate, and 4-(2-pyridinium azo)resorcinol. This electrolyte can prepare FeCoNiCu high-entropy alloy coatings with similar atomic ratios of metal elements in a one-step electrodeposition process, achieving co-deposition of four elements. The addition of additives can improve cathodic polarization, refine grains, and prepare a dense coating exhibiting excellent wear resistance. Simultaneously, the process is simple, low-cost, environmentally friendly, non-toxic, and safe.

This invention relates to a method for preparing 2,5-furandicarboxylic acid compounds. The method includes: providing a hexose diacid compound, an acid catalyst, and an ionic liquid; and dehydrating the hexose diacid compound in the ionic liquid under the catalysis of the acid catalyst to form the 2,5-furandicarboxylic acid compound. The ionic liquid comprises a cationic moiety selected from pyridinium, pyridazinium, pyrimidinium, pyrazinium, oxazinium, thiazinium, imidazoline, pyrazolium, thiazoline, isothiazinium, oxazolium, isoxazolium, or triazolium, and an anionic moiety selected from halide anions. The acid catalyst comprises trifluoromethanesulfonic acid. The general structural formula of the hexose diacid compound is R1OOC(CHOH)4COOR2, and the structure of the 2,5-furandicarboxylic acid compound is shown in formula (I). This method offers mild reaction conditions; good FDCA selectivity and high yield; high product purity; simple operation; and low pollution.

This invention discloses a method for preparing a porous electrospun scaffold based on polycaprolactone and acetylglucan, and its application. The preparation method includes: dissolving glucan in an organic solvent, reacting it with pyridinium 4-methylbenzenesulfonate and 2-methoxypropylene under nitrogen protection, followed by termination, precipitation, centrifugation, washing, and freeze-drying to obtain acetylated glucan; subsequently, dissolving it and a polymer separately in a mixed solvent of dichloromethane and N,N-dimethylformamide, and spinning it into a film using a bilayer coaxial electrospinning technique to prepare a porous scaffold. This scaffold exhibits strong stability, excellent biocompatibility, and the ability to promote tissue repair, making it suitable for the treatment of spinal cord injuries. In particular, it can precisely target the injured site via in-situ drug delivery, reducing the impact on normal tissues and achieving highly efficient repair effects.

This invention discloses a method for preparing a temperature- and salt-resistant ultra-low interfacial tension composite oil displacement agent, comprising multiple steps including preparing a zwitterionic hydrophobic associating polymer, preparing a zwitterionic hydrophobic associating polymer, and preparing a zwitterionic hydrophobic associating polymer. The composite oil displacement agent prepared by this invention exhibits excellent temperature and salt resistance. The core component, the zwitterionic hydrophobic associating polymer, significantly enhances the salt resistance of the oil displacement agent by introducing a zwitterionic structure containing pyridinium cations and sulfonate anions, utilizing the electrostatic balance between ions. It can withstand high salinity of 20×10⁴~30×10⁴ mg / L. At the same time, the rigid naphthalene ring structure in the functional monomer effectively improves the thermal stability of the polymer molecular chain, enabling the oil displacement agent to retain a viscosity of ≥85% after aging at a high temperature of 120~150℃ for 72h, thus solving the problem of performance failure of traditional HPAM-type oil displacement agents under high temperature and high salt conditions.

The present application relates to the technical field of organic synthesis, in particular to a synthesis method of 2,2,2-triphenylacetophenone, steps comprising: 1) preparing mesoporous SiO2 supported triflic anhydride catalyst, realizing solid-liquid separation and circulation of the catalyst; 2) adding pyridine in a segmented temperature control (0-5℃ initial drop, 15-20℃ subsequent drop) mode, reacting with the supported catalyst and benzopinacol in dichloromethane at 20℃ for 2h to avoid local overheating to generate byproducts; 3) after reaction, the catalyst is recovered by filtration, the mother liquor is washed with water, dried, concentrated to obtain a crude product, and then recrystallized with petroleum ether-ethyl acetate (volume ratio 8:1) double solvent to improve the purity to the pharmaceutical grade; 4) dichloromethane is recovered by a three-stage process of "calcium chloride water removal-normal pressure distillation-molecular sieve dehydration-precision filtration", and the recovery rate is ≥90%; 5) the byproduct pyridinium triflate is converted into pyridine and triflic acid by alkaline hydrolysis-acidification, and is reused in the catalytic system.

A composition containing polytetrafluoroethylene and substantially free from a compound represented by Formula (3):wherein M2 is H, a metal atom, NR54 (where R5s may be the same as or different from each other and are each H or an organic group having 1 to 10 carbon atoms), an imidazolium optionally having a substituent, a pyridinium optionally having a substituent, or a phosphonium optionally having a substituent, and q is 1 or 2. Also disclosed is a molded boy including the composition.

This invention provides a diesel anti-wear agent and its preparation method, belonging to the technical field of diesel additives. The method includes the following steps: mixing and stirring diisooctyl maleate and xylene, adding diethylenetriamine and deionized water, heating and reacting, adding toluene, 4-(aminomethyl)pyridine, and ethylene oxide, mixing and reacting to obtain pyridinium-based polyester hollow capsules; mixing xylene, catechol, ethylenephosphonic acid, ammonium persulfate, and deionized water, heating, dispersing in cyclohexane, adding polyvinyl alcohol, octadecyl methacrylate, and azobisisobutyronitrile, mixing and reacting to obtain catechol phosphonate nanoparticles; mixing and stirring fatty acid ester solution, oleoyl fluorocarbon copolymer, and pyridinium-based polyester hollow capsules, adding catechol phosphonate nanoparticles, continuously stirring, sonicating, and degassing to obtain the diesel anti-wear agent. This invention can improve the anti-wear and deemulsification properties of diesel anti-wear agents.

This invention relates to a chiral method for preparing thiamphenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and carries out an asymmetric aldol reaction in the presence of a pyridinium salt carbonyl catalyst, followed by a reduction and amidation reaction to obtain thiamphenicol. This invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starts with inexpensive and readily available raw materials, reduces the steps of introducing and removing protecting groups, shortens the synthetic route, and efficiently synthesizes optically pure thiamphenicol. Furthermore, the preparation method of this invention is simple to operate and environmentally friendly.

This invention discloses a hypochlorous acid and hydrogen peroxide dual-response fluorescent probe compound based on a phenothiazine skeleton, its synthesis method, and its applications. The probe is prepared by nucleophilic addition reaction of phenothiazine with pyridinium salt of 4-cyanomethylphenylboronic acid, using phenothiazine as the core skeleton. The probe exhibits high sensitivity and selectivity for hypochlorous acid and hydrogen peroxide, with detection limits of 0.04 μM and 0.13 μM, respectively. The fluorescence emission wavelength difference between the two response channels reaches 220 nm, enabling simultaneous detection through both channels. This probe can monitor changes in endogenous and exogenous hypochlorous acid and hydrogen peroxide levels in living cells in real time and in situ, and has been successfully applied to the detection of biological processes such as ferroptosis, drug-induced liver injury, and oxidative stress. Furthermore, this probe can also be used for the quantitative detection of hypochlorous acid and hydrogen peroxide content in food and water samples, showing broad application prospects in the fields of biosensing, disease diagnosis, and food safety testing.

Emulsions that include a pyridinium-based compound functionalized by including a heteroatom substituents containing at least one oxygen, nitrogen, or sulfur atoms are provided. Also provided are methods for extracting hydrocarbons in a downhole environment utilizing such emulsions. Also provided are methods for transporting hydrocarbons in a pipeline utilizing such emulsions. Also provided are methods for cleaning a tank housing hydrocarbons utilizing such emulsions.

This invention discloses a cell membrane-targeted H2S two-photon fluorescent probe, its preparation method, and its applications. This probe not only possesses excellent optical properties such as near-infrared fluorescence emission at 650 nm, a large Stokes shift of 140 nm, and two-photon excitation characteristics, exhibiting advantages such as low excitation-emission light scattering, low tissue absorption, and strong penetration, but also demonstrates excellent analytical and detection performance. Its pyridinium and sulfonic acid groups prevent it from entering the cell interior, allowing it to adhere only to the cell membrane surface, thus endowing the probe with excellent cell membrane localization capabilities. The probe uses a 2,4-dinitrobenzenesulfonyl group as both the H2S recognition group and a fluorescence quencher. Because the 2,4-dinitrobenzenesulfonyl group is adjacent to the pyridinium group, it is located on the outer surface of the cell membrane, enabling two-photon fluorescence imaging of H2S released transmembrane from cells.

This application discloses perovskite solar cells, photovoltaic modules and electrical devices, polydicationic ionic liquids, and their preparation methods. The perovskite layer includes two corresponding surfaces, at least one of which has a passivation layer comprising a polydicationic ionic liquid. The side groups of the repeating units of the polydicationic ionic liquid contain dicationic ionic liquid functional groups, which include a first cationic group and a second cationic group. The second cationic group is connected to the main chain structure of the repeating unit and is also connected to the first cationic group through bridging groups. The first and second cationic groups are each independently selected from one of imidazolium ions, pyrrolidineium ions, pyridinium ions, piperidinium ions, piperazineium ions, quaternary ammonium salt cations, and quaternary phosphate salt cations. The perovskite solar cells provided by this application have high photoelectric conversion efficiency.

This invention belongs to the field of electrochromic devices, specifically relating to a room-temperature, in-situ spontaneously polymerizable ionic gel electrolyte composition, which can be used in devices such as smart windows and flexible displays, as well as the electrolyte and its applications. The composition includes a liquid precursor solution and an initiator; the liquid precursor solution is a liquid containing a polymer network framework material, an ionic liquid electrolyte, 1,3-dioxolane, an epoxy crosslinking agent, a viologen derivative electrochromic material, and a ferrocene derivative counter electrode material; the initiator is a combination of lithium bis(trifluoromethanesulfonyl)imide and the initiator trifluoroacetic acid; the cation of the ionic liquid electrolyte is selected from at least one of imidazolium cations, pyrrolidineonium cations, pyridinium cations, and / or quaternary ammonium cations. The composition of this invention can generate a gel electrolyte without external energy input, and the electrochromic device prepared therefrom possesses characteristics such as high ionic conductivity, excellent optical performance, good interfacial stability, and long cycle life.

This invention relates to a chiral preparation method for chloramphenicol. Specifically, the method uses p-nitrobenzaldehyde and glycine ester as starting materials, and an asymmetric aldol reaction occurs under the action of a pyridinium salt carbonyl catalyst. Following reduction and amidation reactions, chloramphenicol is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to efficiently control the stereoselectivity of the aldol reaction, and to obtain the desired stereoconfiguration product, chloramphenicol, in a single dose. The preparation method of this invention reduces the protection of active groups, shortens the chiral synthetic route of chloramphenicol, is simple to operate, and is environmentally friendly.

This invention provides novel sulfate esters or salts thereof having two or more carbonyl groups, and surfactants. A compound, characterized by having the formula: R 1 -C(=O)-R 2 -C(=O)-R 3 -OSO3X represents this. (In the formula, R) 1 It is a straight-chain or branched alkyl group with 1 or more carbon atoms, or a cyclic alkyl group with 3 or more carbon atoms, wherein the hydrogen atoms bonded to the carbon atoms are not substituted or are substituted by hydroxyl groups or monovalent organic groups containing ester bonds. If it has 2 or more carbon atoms, it may contain a carbonyl group. If it has 3 or more carbon atoms, it may contain monovalent or divalent heterocycles, or it may be rolled into a ring. R 2 and R 3 Independently a single bond or a divalent linker. R 1 R 2 and R 3 The total number of carbon atoms is 6 or more. X is H, a metal atom, or NR. 4 4. Imidazolium with or without substituents, pyridinium with or without substituents, or phosphonium with or without substituents, R 4 It can be an H or an organic group, and can be the same or different. R 1 R 2 and R 3 (In this context, any two elements can bond together to form a ring.)