291 results about "LIGHT STIMULATION" patented technology

The invention relates to an intelligent sleep adjusting method and system based on closed-loop acousto-optic brain wave entrainment, electroencephalogram (EEG) signals are collected and preprocessed in real time through a wireless dry electrode, and high-precision sleep staging is achieved through a deep learning model. The system adopts a fuzzy PID (Proportion Integration Differentiation) controller to dynamically adjust acousto-optic synergistic stimulation: an acoustic module generates binaural beat signals, an optical module outputs blue light (470nm) and amber light (590nm) pulses, and the brain wave entrainment efficiency is enhanced through phase synchronization (the phase difference is less than or equal to 10 degrees) and golden section frequency coupling (fL is equal to 1.618 fA). Parameters are updated every 30 seconds through closed-loop feedback, the sound pressure level (30-50 dB) and the light intensity (10-100 lux) are adjusted according to the Weber-Fechner law, and the response delay is lt; the time is 200 ms. A three-level safety mechanism monitors gamma wave abnormity, epilepsy sample discharge and impedance overrun in real time, and triggers graded protection (alarming, cutting off light stimulation and shutdown). Clinical verifications show that the entrainment success rates of the delta wave and the theta wave respectively reach 71% and 68%, the sleep improvement effect is good, and a safe and efficient intervention scheme is provided for sleep disorders.

The invention relates to the field of neuroscience experiments, and discloses a method for accurately adjusting the precision of targeted light and calibrating neuron sampling images, which comprises the following steps of: 1, acquiring image data containing neuron activity information; step 2, preprocessing the image data to remove artifact noise; step 3, modeling the deformation of the nervous tissue based on the image data; step 4, regulating and controlling optical system parameters for targeted light stimulation according to a deformation modeling result; and 5, closed-loop updating is performed on the modeling result and the regulation and control parameters based on feedback image data, the image data in the step 1 comprises a calcium imaging image and a targeted light feedback image which are synchronously acquired, the calcium imaging image is used for reflecting neuron activity, and the targeted light feedback image is used for calibrating a light spot position. By adopting an accurate calcium imaging technology and a targeted light feedback image synchronous acquisition scheme, real-time synchronization of neuron activity and light spot position is realized.

The utility model relates to the field of medical instruments, in particular to an auxiliary sleep device with a sound wave hypnosis function, which comprises a base, a support block, a seat, a backrest, a headrest, an electric push rod and the like, the upper side of the middle of the base is connected with the support block, the upper side of the support block is connected with the seat, the left part of the seat is rotatably connected with the backrest, and the upper side of the backrest is connected with the headrest. The left part of the backrest is rotationally connected with an electric push rod. The window shade is put down by pushing the connecting frame to move and then reversely pulling the pull bead chain, and then sound waves are sent out by the ultrasonic sleep aiding device for hypnosis to assist sleep, so that the sound waves can be used for hypnosis of a user to assist sleep, relax the brain and accelerate falling asleep, and meanwhile, the window shade can be used for shading. A user is in a dark environment, light stimulation is avoided, the sleep quality is improved, and use is convenient.

The invention relates to the technical field of nerve probes, and provides a four-mode integrated nerve probe and a preparation method thereof. The four-mode integrated nerve probe provided by the invention comprises a flexible substrate, an electric signal recording module, an ultrasonic stimulation module, a light stimulation module and a microfluidic channel. The electric signal recording module is used for recording electroneurographic signals, the ultrasonic stimulation module is used for ultrasonic stimulation, the optical stimulation module is used for optical stimulation and signal recording, and the microfluidic channel is filled with drugs through a microfluidic channel control port in the probe body and releases the drugs through a microfluidic channel outlet in the needle tip. According to the four-mode integrated nerve probe provided by the invention, multiple functions are integrated into one probe, so that comprehensive detection and regulation of a nervous system are realized, and the technical problems that a traditional nerve probe is single in function, inflammation is caused by a rigid material and multi-mode integration is insufficient are solved.

The invention discloses a near-infrared light controllable irradiator for astroganglion stimulation, which comprises a physiological signal acquisition module used for acquiring a near-infrared light sensing signal of a carotid artery area in real time; the signal processing module is used for performing variational mode decomposition on the near-infrared sensing signal and extracting a heart rate component; the autonomic nerve analysis module is used for receiving the heart rate component and calculating the excitement ratio of sympathetic nerves to parasympathetic nerves; a deep learning model is arranged in the control signal generation module, and an optical parameter control signal is generated according to the heart rate cycle characteristics and the excitement ratio; and the light adjusting module is used for receiving the light parameter control signal so as to control the emission of near-infrared light. According to the invention, the output of the infrared light can be adjusted according to the physiological signal of the human body, intelligent adjustment is realized, the near-infrared light stimulation better fits the individual condition, and the pertinence and effectiveness of the stimulation are effectively improved.

The invention provides a novel light-sensitive channel protein VR2.0 and application thereof. The photosensitive channel protein VR2.0 series provided by the invention has an obvious treatment effect in treatment of retina photoreceptor cell degenerative diseases. The novel light-sensitive channel protein has higher light sensitivity, fast dynamics and low side effect; under the same light stimulation condition, the response frequency is fast, and stable current signals can be kept under high frequency response. The application provides a better choice for developing photogenetic therapy for retina photoreceptor cell degenerative diseases, and has important application and popularization values.

The invention provides an acousto-optic stimulation rehabilitation training system. The acousto-optic stimulation rehabilitation training system comprises a wearable optical stimulator; the wearable light stimulator comprises a central view field area and a peripheral view field area; the central field-of-view area has an observation mode and a training mode, and when the central field-of-view area is in the observation mode, the central field-of-view area is configured to allow perspective; when the central view field area is in the training mode, the central view field area is configured to display interactive training information; the peripheral field-of-view region has a stimulation mode, and when the peripheral field-of-view region is in the stimulation mode, the peripheral field-of-view region is configured to emit non-photosensitive stimulation. By dividing the central field of view and the peripheral field of view and setting the stimulation mode in the peripheral field of view, the interference of light to the central field of view of human eyes can be reduced or avoided. The stimulation mode gives out non-photosensitive stimulation, so that the perception of human eyes to flicker can be reduced while the treatment effect is achieved, and visual fatigue is reduced. While light stimulation is realized, the requirements of daily actions and training are met.

Embodiments disclosed herein can provide ocular photo-bio- stimulation through light stimulation of specific wavelengths to the eye's retina, and to the entire eye's retina, the retina peripheral to the fovea, and / or the retina peripheral to the macula. In certain embodiments, the light stimulation is targeted at or to the rods. In other embodiments, the light stimulation is targeted at or to the ganglion cells or it is targeted at or to the rods and the ganglion cells, wherein the ganglion cells targeted or stimulated are the melanopsin containing ganglion cells (ipRGCs) or can also be called mRGCs.

The invention discloses a method for detecting aflatoxin B1 in coffee based on colorimetric and photo-thermal dual modes of MXene (at) Pt nano-enzyme, which comprises the following steps: etching Ti3AlC2 by using LiF and HCl to obtain MXene, synthesizing platinum nano-particle modified MXene nano-enzyme (MXene (at) Pt) by using dopamine carbon dots and sodium borohydride as reducing agents and adopting an in-situ reduction technology, and detecting aflatoxin B1 in coffee by using the MXene (at) Pt nano-enzyme (MXene (at) Pt nano-enzyme (MXene (at) Pt nano-enzyme (MXene (at) Pt nano-enzyme (MXene (at) Pt). The MXene (at) Pt shows near-infrared light stimulation enhanced peroxidase-like activity and photo-thermal performance and can catalyze blue deepening and temperature rising of a substrate 3, 3 ', 5, 5'-tetramethyl benzidine (TMB), when aflatoxin B1 exists, POD-like activity of MXene (at) Pt nano-enzyme is inhibited, and colorimetric and temperature signals are reduced; a method for detecting the AFB1 by the colorimetric temperature dual-mode sensor is established, and the method has the characteristics of high sensitivity, strong specificity, simplicity and rapidness in operation and the like.

The present invention relates to a multiphoton imaging system, a multiphoton stimulation system and a multiphoton imaging and stimulation system. The system switches the system optical path to a multiphoton imaging optical path, an adaptive optical multiphoton imaging optical path, a multiphoton optical stimulation optical path or a multiphoton holographic optical stimulation optical path by adjusting the position of an electrically controlled movable reflector. Compared with the prior art, the present invention can achieve high-precision multiphoton imaging and single-cell precision multiphoton optical stimulation.

The invention provides a visual stimulation method and device based on non-imaging visual response, equipment and a program product, and relates to the technical field of electronics. Visual stimulation signals capable of triggering non-visual light stimulation are creatively applied to two visual channels of a user respectively in a time asynchronous mode. The visual channel which preferentially senses the stimulation signal enables the stimulation signal to directly stimulate the corresponding sensing channel through the photosensitive sensing cell due to non-imaging visual response. The image content of the stimulation signal needs to be perceived by the brain only after the stimulation signal is received in the other visual channel. Therefore, based on the visual stimulation method, the non-visual light stimulation and the visual image stimulation generated by the light stimulation signal are not synchronous in time, so that the mutual influence of the two processes is reduced, the stimulation effect of the non-visual light stimulation is improved, and the shaping capability of the non-visual light stimulation on a corresponding perception path is enhanced.

The utility model provides a monocular stimulation device which is used for being detachably clamped on a target object. The monocular stimulation device comprises an outer clamping body, an inner clamping body, a potential energy unit and a light source unit, the outer clamping body and the inner clamping body are oppositely arranged, and the potential energy unit applies potential energy to the outer clamping body and the inner clamping body, so that the outer clamping body and the inner clamping body are clamped on a target object; the light source unit is arranged in the inner clamping body and used for emitting light with preset parameters towards the inner side of the target object. According to the configuration, the monocular stimulation device can be conveniently loaded on the target object to carry out monocular light stimulation in a detachable clamping mode, can be detached from the target object after being used, is convenient to use, does not cause limitation of movement of a user, and is particularly suitable for the user wearing glasses.

The invention relates to a control method of optical acupuncture, which comprises the following steps: a control system continuously applies a plurality of optical stimulation pulses lower than a nerve excitation threshold value, and target acupuncture point nerves enter a subcritical energy storage state through membrane potential superposition after synapse; laser output intensity is increased, and a directional threshold crossing pulse is emitted to trigger nerve discharge; judging the principal axis direction of local tissue fibers, and adjusting the laser incident angle, so that a light beam penetrates along the principal axis direction to trigger compliant tissue resonance; two beams of frequency differential laser are used for cross irradiation in a non-treatment acupoint area needing suppression to form fixed interference fringes, and a minimum power drop point is calculated to cover and suppress a target acupoint, so that the acupoint is always in an interference offset zone in the treatment process to form a selective function suppression window; a control system synchronously collects heart rate and respiration signals of a user, extracts respective periods to calculate a minimum common rhythm, sets a subsequent light stimulation rhythm as a physiological rhythm differential resynchronization frequency, and enables alternating resonance activation of different neural rhythms through phase staggering.

The invention provides a rigidity-flexibility variable multifunctional optical genetic implantable probe and a preparation method thereof. The probe comprises a thin film electrode layer and a rigidity-flexibility variable shape memory layer arranged at the bottom of the thin film electrode layer. The micro LED is integrated in the flexible nerve probe through contact type laser transfer printing to serve as a light stimulation light source, the preparation success rate is remarkably increased, heat radiated outwards during light stimulation is reduced, and damage to brain tissue of the brain caused by high-Young-modulus optical fibers is avoided; meanwhile, a rigid-flexible variable shape memory layer is also integrated, so that the Young modulus of the probe is high when the in-vitro temperature is relatively low, fixed-point implantation can be directly carried out without an auxiliary tool, the Young modulus of the probe is reduced along with the rise of the body temperature after the probe is implanted into the body, and the probe finally adapts to the mechanical tissue strength of the brain; therefore, the implantation efficiency and the mechanical adaptability of the probe to brain tissues are improved, and micron-scale accurate implantation of the probe, neuron-scale positioning of electrical stimulation and light stimulation points and long-term stable recording of electrophysiological signals are realized.

The invention discloses an intelligent sleep detection and intervention eyeshade system and method combined with a brain-computer interface, and belongs to the technical field of sleep detection and intervention. The intelligent sleep detection and intervention eyeshade system comprises a neural signal detection module, a core control module, a bone conduction module and a light stimulation module; the core control module is electrically connected with the neural signal detection module, the bone conduction module and the light stimulation module. Through the neural signal detection module, the system can perform electroencephalogram monitoring on a user and detect a corresponding neural signal of the user, real-time analysis is performed through the core control module based on a brain-computer interface technology to obtain an accurate sleep detection result, personalized sleep detection is provided for the user, and the sleep quality of the user can be improved according to the personalized sleep detection result. And real-time sleep intervention is realized, so that the sleep intervention effect on the user is improved.

According to the invention, a collaborative deformable mirror, a two-dimensional galvanometer scanning system and a high-precision three-dimensional displacement sample table are designed, and rapid tracking and spot scanning imaging of a freely moving sample are completed. And under the condition of single cell analysis resolution, the tracking range is large, and the imaging speed is high. As the galvanometer controls the deflection angle through the driving voltage, the propagation path of the imaging light path can be efficiently adjusted in real time. Therefore, the tracking response speed based on the galvanometer scanning system is obviously superior to that of a traditional mechanical displacement compensation mode. The displacement is compensated through the sample table, and the tracking range is expanded. The displacement compensation process adopts a sample motion trail pre-judgment algorithm, is carried out in real time and is small in compensation amount, and rapid response of the system is ensured; displacement compensation and galvanometer tracking work cooperatively, the tracking speed is optimized, and spot scanning imaging is completed at the same time. Axial scanning is completed by modulating excitation light wave front through a deformable mirror. The system is integrated with a light stimulation module, wavefront phase modulation is carried out on stimulation light by utilizing a spatial light modulator, single-point or multi-point focusing is realized, single or multiple neurons can be accurately controlled, and the system has important significance on research of neuroscience.

The invention discloses a system for analyzing the influence of photostimulation on amygdala function regulation and control, and relates to the field of brain nerve regulation and control, the system comprises a photostimulation module, an intracranial electroencephalogram recording module and an amygdala physiological activity analysis module, the photostimulation module issues intermittent photostimulation to a subject; the intracranial electroencephalogram recording module is used for recording continuous electroencephalogram signal data of the amygdala before and during photostimulation of the subject; the amygdala physiological activity analysis module preprocesses the electroencephalogram signal data, judges the amygdala function change of a specific frequency band according to the neural oscillation energy change rate of the specific frequency band, and forms an optical frequency-amygdala function change database, thereby obtaining the optical stimulation frequency influencing the amygdala function. The invention can overcome the problem that the scalp electroencephalogram is difficult to capture the nerve activity of the amygdala nucleus; in addition, the photostimulation frequency capable of influencing the functions of the amygdala kernel is obtained, and clinical reference is provided for accurately intervening the functions of the amygdala kernel.

The invention provides a 40Hz acousto-optic stimulation dynamic optimization system based on electroencephalogram closed loop feedback, belongs to the technical field of cognitive disorder treatment, and solves the technical problems that an existing stimulation system lacks a dynamic closed loop, ignores individual differences, lacks a cross-band coupling mechanism and the like. Comprising an electroencephalogram gamma oscillation power detection module, an embedded signal processing and analysis module, a stimulation parameter generation and execution adjustment module, a personalized strategy database module, a multiple safety protection module, an edge calculation and communication module, a user interaction module, a head-mounted acquisition and stimulation device, a scene adaptation engine module and a double-loop closed-loop feedback control module. And the processing algorithm module comprises user terminal equipment with application software and a cloud central processing unit. According to real-time electroencephalogram feedback, a personalized historical data strategy library and an algorithm, parameters of 40Hz acousto-optic stimulation can be dynamically adjusted by relying on a double-loop closed-loop feedback control mechanism, and a mature cloud-edge-end cooperative computing ecosystem is constructed.

The invention discloses a phototherapy reagent and a preparation method and application thereof. The preparation method comprises the following steps: 1-[4-(diethylamino) phenyl]-ethane-1-ketone and 4-methoxybenzaldehyde are subjected to a condensation reaction in a NaOH ethanol solution, and a product and nitromethane are subjected to addition; performing condensation and addition on the other groups of raw materials by the same method; cyclizing the two addition products with ammonium acetate, and coordinating with boron trifluoride diethyl etherate to obtain NHM; carrying out substitution reaction on the NHM and sodium nitrite to obtain NOO; and oxidizing NOO by m-chloroperoxybenzoic acid to obtain NNOO. The reagent can target a tumor hypoxia microenvironment, hypoxia monitoring is achieved, NO is released through photostimulation for tumor gas therapy, meanwhile, the secondary amplification photo-thermal therapy effect is achieved, preparation is controllable, diagnosis and treatment are integrated, and the reagent is sensitive, safe and suitable for biomedical research and clinical diagnosis.

A system and method for determining and modifying the electromagnetic activity of a patient's heart includes a sensor array, a controller, software, and a stimulator array. The sensor array includes one or more sensors, such as an ECG electrode, that detect the electromagnetic activity of a patient's heart. The sensor array is in data communication with the controller. The controller runs software that outputs in human-format sensor data provided by the sensor array. The software receives data from the controller, analyzes the data, presents the data to the user, and sends the data to the stimulator array via a data communication link. The stimulator array includes one or more electromagnets and at least one or more light-emitting diodes. The stimulator array emits an electromagnetic (and / or light) field to modify the electromagnetic activity of a patient's heart based on the data it receives from the controller. The system can be portable.

The invention belongs to the technical field of design and manufacture of physiotherapy equipment, and particularly discloses a scalp partition photostimulation system, method and equipment based on a five-transportation-six-qi theory, a medium and a program product. The system comprises an upper computer operation module, a communication module, a main control module, a multi-channel driving circuit and a headgear structure. The technical problems that in the prior art, a five-transportation-six-gas-based head stimulation device cannot be accurately matched with standardized selective logic, and the stimulation mode has skin side effects are solved, and the technical effects that the selective logic is standardized and objective, the target spot is accurate and repeatable, and the safety and the user acceptability are improved are achieved.

The invention discloses a photostimulation artificial cochlea which comprises an in-vitro machine and an implant, the in-vitro machine is divided into a sound processor and a transmitting coil, the in-vivo implant is divided into a receiving coil, a decoder and a nano laser, and the sound processor is used for processing sound signals and generating corresponding current parameters; the transmitting coil is used for transmitting a radio-frequency signal carrying a current parameter to the in-vivo implant by utilizing electromagnetic induction; the receiving coil is used for receiving the radio frequency signal transmitted by the transmitting coil; the decoder is used for analyzing the radio-frequency signal, restoring the radio-frequency signal into an electric signal and sending the electric signal to the corresponding nano laser; the nanometer laser is used for converting a received electric signal into a laser signal, and the laser signal is irradiated to the auditory nerve element through the optical fiber or directly irradiated to realize optical stimulation. According to the invention, efficient and fidelity transmission and processing of sound are realized, auditory definition and spatial resolution of a user are improved, and more natural and comfortable auditory experience is provided for a patient with hearing impairment.

The invention discloses a multi-modal biophysical characterization device, a multi-modal biophysical characterization system, a multi-modal biophysical characterization method and application thereof. The multi-modal, high-resolution, high-throughput, high-sensitivity, low-cost, low-damage and configurable physical characterization of single cells or multi-cell polymers can be realized, stimulation (such as mechanical stimulation, electrical stimulation and light stimulation) of different types and intensities can be performed on a to-be-detected sample, and the in-vivo microenvironment can be better simulated; and carrying out operations (such as marking, curing, ablation, cutting, extraction, sorting and the like) on samples at specific positions or regions, and carrying out comparative analysis in combination with other characterization methods (such as protein staining, histochemical staining, single cell sequencing and the like). The multi-mode biophysical characterization device is suitable for the fields of synthetic biology, diagnosis, drug discovery, tumor early screening, cell therapy, precision medical treatment and the like.

The invention relates to the technical field of floor table lamps, and discloses a vertical type floor eye protection table lamp which comprises a shell, a lamp holder, a control switch, a covering and shielding module, an air supply blowing module and a temperature control self-replacement module, and the covering and shielding module is used for eye protection lighting of a user, and the user conducts shielding adjustment on the position, corresponding to a strong light reflection area on a lighting table top, of the covering and shielding module. The air supply blowing module conducts directional air supply heat dissipation treatment on the overheated lamp holder, accumulated dust on the top of the lamp holder is wiped through the temperature control self-replacement module, the temperature is prevented from being too high, a dirty wiping object is automatically replaced when the temperature is too high, and it is guaranteed that irradiation light rays on the top of the lamp holder are not affected; mirror reflection generated by the strong light reflection area is covered, the coverage range of the polarizing film is adjusted according to the range of the strong light reflection area, and light with wavelength is filtered through the polarizing film, so that mirror reflection light of the strong light reflection area is darkened, stimulation of strong light of mirror reflection to eyes of a user is reduced, and comfort of the eyes in the using process is guaranteed.

The utility model discloses a medicine information verification device based on diffuse reflection, and belongs to the technical field of medical equipment. The upper end face of the outer box body is provided with a transparent detection panel and an LED light source facing the interior of the outer box body. The inner box body is fixedly mounted in the outer box body; the upper end of the inner box body is open, a movable bottom plate is arranged at the bottom end of the inner box body, and a through hole is formed in the movable bottom plate; the camera bracket is fixed below the movable bottom plate; the camera is fixed on the camera bracket in a height-adjustable manner; and a lens of the camera is arranged in the through hole of the movable bottom plate in a penetrating manner and faces the detection panel. According to the utility model, through the diffuse reflection illumination design, the eyes of a pharmacist are effectively prevented from being stimulated by light rays, the comfort and accuracy of medicine information verification are improved, and accurate collection of medicine information is facilitated; the movable bottom plate of the inner box body can be adjusted along with the up-down change of the movable camera to adapt to different verification requirements; the design of the detection panel and the steps facilitates the placement and verification of medicines.

The application discloses a kind of light stimulation, electric stimulation, concentration gradient combined control device and preparation method, including light stimulation light intensity gradient chip layer, cell capture culture chip layer and microelectrode layer;Cell capture culture chip layer is provided with several main sample introduction sections and several capture culture channels;Capture culture channel is provided with several groups of capture culture cavities, and capture culture cavity is provided with several capture structures;Light stimulation light intensity gradient chip layer is provided with several main liquid introduction sections and several light intensity adjustment channels, and each light intensity adjustment channel is provided with light intensity adjustment section;The interdigital electrode region on microelectrode layer corresponds to the position of capture culture cavity.There is also S1-S5 etc.Preparation step.The light stimulation, electric stimulation, concentration gradient combined control device of the application can realize integrated multi-factor combined stimulation based on microfluidic platform, parallel experiment, high integration, multiple units are operated simultaneously, and has the advantages of small pollution risk, low reagent loss etc..

A transition metal chalcogenide flake manufactured by the molten salt-assisted thermal chemical vapor deposition method according to a preferred embodiment can be uniformly and evenly grown on a large-area substrate with a size of several to several hundred micrometers in scale, and a light-gated transistor using this as a light sensing layer can perform logical operations of AND, OR, and summation operations in response to light stimulation and enable a low-power synaptic operation response.

A system for producing a three-dimensional object from a fluid medium includes image processing units. The fluid medium is configured to solidify when subjected to a prescribed light stimulation. Each image processing unit includes at least one light emitting source configured to emit light, and at least one mirror system configured to reflect the light emitted by the light emitting source. The mirror system includes a manipulating system for adjusting the direction of the emitted light, a control system for controlling the manipulating system, and at least one optical element configured to manipulate the emitted light and to project the emitted light onto an area of a surface of the fluid medium to form an image on the surface. The image processing units are configured to form corresponding images on the surface, and are configured to be movable at least in a lateral direction relative to the surface.

The present invention relates to the technical field of light-driven structure design, which solves the technical problem that traditional burst structures stop after a single burst and need to rely on manual or electrical signal triggering to reset, making it difficult to achieve continuous autonomous action. In particular, it relates to a self-excited burst light-driven structure and its self-control method, and the light-driven structure includes a protective shell, a control component, and a fixing part. The liquid crystal elastomer sheet in the composite sheet has a photothermal response characteristic, and when subjected to external photothermal stimulation, it will shrink and deform, driving the free end of the composite sheet to bend to one side and enter the non-illuminated area, and then dissipate heat to recover and re-enter the illuminated area to achieve a self-sustaining process. The present invention can maintain an autonomous, multiple, and continuous burst process under constant light stimulation, and has the advantages of simple structure, sensitive response, and energy self-sustaining. It provides a new solution for the development of efficient and autonomous light-driven burst devices, showing greater research value and application potential.

The application discloses a kind of non-contact physiological signal monitoring systems based on image recognition, comprising: evoked collection module, for output light stimulation sequence and gaze guide sequence, and the high frame rate video image of the body area of target object is collected;Unit mapping module is used to construct multiple physiological response units, generate physiological response unit topology chart;Demodulation extraction module is used to perform encoding demodulation processing, generate unit evoked response feature set;Transmitting configuration module is used to construct physiological response transmission atlas;Separation correction module is used to separate and inhibit unit evoked response feature set;Inversion analysis module is used to carry out inversion, generate physiological inversion parameter set;Calibration compensation module is used to construct individual response calibration model and carry out compensation correction;Abnormal output module is used to generate abnormal monitoring result.The application multi-region image recognition, realize non-contact physiological signal monitoring.