146 results about "LIGHT STIMULATION" patented technology

The invention discloses a method for detecting aflatoxin B1 in coffee based on colorimetric and photo-thermal dual modes of MXene (at) Pt nano-enzyme, which comprises the following steps: etching Ti3AlC2 by using LiF and HCl to obtain MXene, synthesizing platinum nano-particle modified MXene nano-enzyme (MXene (at) Pt) by using dopamine carbon dots and sodium borohydride as reducing agents and adopting an in-situ reduction technology, and detecting aflatoxin B1 in coffee by using the MXene (at) Pt nano-enzyme (MXene (at) Pt nano-enzyme (MXene (at) Pt nano-enzyme (MXene (at) Pt nano-enzyme (MXene (at) Pt). The MXene (at) Pt shows near-infrared light stimulation enhanced peroxidase-like activity and photo-thermal performance and can catalyze blue deepening and temperature rising of a substrate 3, 3 ', 5, 5'-tetramethyl benzidine (TMB), when aflatoxin B1 exists, POD-like activity of MXene (at) Pt nano-enzyme is inhibited, and colorimetric and temperature signals are reduced; a method for detecting the AFB1 by the colorimetric temperature dual-mode sensor is established, and the method has the characteristics of high sensitivity, strong specificity, simplicity and rapidness in operation and the like.

The invention provides a rigidity-flexibility variable multifunctional optical genetic implantable probe and a preparation method thereof. The probe comprises a thin film electrode layer and a rigidity-flexibility variable shape memory layer arranged at the bottom of the thin film electrode layer. The micro LED is integrated in the flexible nerve probe through contact type laser transfer printing to serve as a light stimulation light source, the preparation success rate is remarkably increased, heat radiated outwards during light stimulation is reduced, and damage to brain tissue of the brain caused by high-Young-modulus optical fibers is avoided; meanwhile, a rigid-flexible variable shape memory layer is also integrated, so that the Young modulus of the probe is high when the in-vitro temperature is relatively low, fixed-point implantation can be directly carried out without an auxiliary tool, the Young modulus of the probe is reduced along with the rise of the body temperature after the probe is implanted into the body, and the probe finally adapts to the mechanical tissue strength of the brain; therefore, the implantation efficiency and the mechanical adaptability of the probe to brain tissues are improved, and micron-scale accurate implantation of the probe, neuron-scale positioning of electrical stimulation and light stimulation points and long-term stable recording of electrophysiological signals are realized.

The invention provides a 40Hz acousto-optic stimulation dynamic optimization system based on electroencephalogram closed loop feedback, belongs to the technical field of cognitive disorder treatment, and solves the technical problems that an existing stimulation system lacks a dynamic closed loop, ignores individual differences, lacks a cross-band coupling mechanism and the like. Comprising an electroencephalogram gamma oscillation power detection module, an embedded signal processing and analysis module, a stimulation parameter generation and execution adjustment module, a personalized strategy database module, a multiple safety protection module, an edge calculation and communication module, a user interaction module, a head-mounted acquisition and stimulation device, a scene adaptation engine module and a double-loop closed-loop feedback control module. And the processing algorithm module comprises user terminal equipment with application software and a cloud central processing unit. According to real-time electroencephalogram feedback, a personalized historical data strategy library and an algorithm, parameters of 40Hz acousto-optic stimulation can be dynamically adjusted by relying on a double-loop closed-loop feedback control mechanism, and a mature cloud-edge-end cooperative computing ecosystem is constructed.

The invention discloses a phototherapy reagent and a preparation method and application thereof. The preparation method comprises the following steps: 1-[4-(diethylamino) phenyl]-ethane-1-ketone and 4-methoxybenzaldehyde are subjected to a condensation reaction in a NaOH ethanol solution, and a product and nitromethane are subjected to addition; performing condensation and addition on the other groups of raw materials by the same method; cyclizing the two addition products with ammonium acetate, and coordinating with boron trifluoride diethyl etherate to obtain NHM; carrying out substitution reaction on the NHM and sodium nitrite to obtain NOO; and oxidizing NOO by m-chloroperoxybenzoic acid to obtain NNOO. The reagent can target a tumor hypoxia microenvironment, hypoxia monitoring is achieved, NO is released through photostimulation for tumor gas therapy, meanwhile, the secondary amplification photo-thermal therapy effect is achieved, preparation is controllable, diagnosis and treatment are integrated, and the reagent is sensitive, safe and suitable for biomedical research and clinical diagnosis.

A system and method for determining and modifying the electromagnetic activity of a patient's heart includes a sensor array, a controller, software, and a stimulator array. The sensor array includes one or more sensors, such as an ECG electrode, that detect the electromagnetic activity of a patient's heart. The sensor array is in data communication with the controller. The controller runs software that outputs in human-format sensor data provided by the sensor array. The software receives data from the controller, analyzes the data, presents the data to the user, and sends the data to the stimulator array via a data communication link. The stimulator array includes one or more electromagnets and at least one or more light-emitting diodes. The stimulator array emits an electromagnetic (and / or light) field to modify the electromagnetic activity of a patient's heart based on the data it receives from the controller. The system can be portable.

The invention belongs to the technical field of design and manufacture of physiotherapy equipment, and particularly discloses a scalp partition photostimulation system, method and equipment based on a five-transportation-six-qi theory, a medium and a program product. The system comprises an upper computer operation module, a communication module, a main control module, a multi-channel driving circuit and a headgear structure. The technical problems that in the prior art, a five-transportation-six-gas-based head stimulation device cannot be accurately matched with standardized selective logic, and the stimulation mode has skin side effects are solved, and the technical effects that the selective logic is standardized and objective, the target spot is accurate and repeatable, and the safety and the user acceptability are improved are achieved.

The utility model discloses a medicine information verification device based on diffuse reflection, and belongs to the technical field of medical equipment. The upper end face of the outer box body is provided with a transparent detection panel and an LED light source facing the interior of the outer box body. The inner box body is fixedly mounted in the outer box body; the upper end of the inner box body is open, a movable bottom plate is arranged at the bottom end of the inner box body, and a through hole is formed in the movable bottom plate; the camera bracket is fixed below the movable bottom plate; the camera is fixed on the camera bracket in a height-adjustable manner; and a lens of the camera is arranged in the through hole of the movable bottom plate in a penetrating manner and faces the detection panel. According to the utility model, through the diffuse reflection illumination design, the eyes of a pharmacist are effectively prevented from being stimulated by light rays, the comfort and accuracy of medicine information verification are improved, and accurate collection of medicine information is facilitated; the movable bottom plate of the inner box body can be adjusted along with the up-down change of the movable camera to adapt to different verification requirements; the design of the detection panel and the steps facilitates the placement and verification of medicines.

The application discloses a kind of light stimulation, electric stimulation, concentration gradient combined control device and preparation method, including light stimulation light intensity gradient chip layer, cell capture culture chip layer and microelectrode layer;Cell capture culture chip layer is provided with several main sample introduction sections and several capture culture channels;Capture culture channel is provided with several groups of capture culture cavities, and capture culture cavity is provided with several capture structures;Light stimulation light intensity gradient chip layer is provided with several main liquid introduction sections and several light intensity adjustment channels, and each light intensity adjustment channel is provided with light intensity adjustment section;The interdigital electrode region on microelectrode layer corresponds to the position of capture culture cavity.There is also S1-S5 etc.Preparation step.The light stimulation, electric stimulation, concentration gradient combined control device of the application can realize integrated multi-factor combined stimulation based on microfluidic platform, parallel experiment, high integration, multiple units are operated simultaneously, and has the advantages of small pollution risk, low reagent loss etc..

A system for producing a three-dimensional object from a fluid medium includes image processing units. The fluid medium is configured to solidify when subjected to a prescribed light stimulation. Each image processing unit includes at least one light emitting source configured to emit light, and at least one mirror system configured to reflect the light emitted by the light emitting source. The mirror system includes a manipulating system for adjusting the direction of the emitted light, a control system for controlling the manipulating system, and at least one optical element configured to manipulate the emitted light and to project the emitted light onto an area of a surface of the fluid medium to form an image on the surface. The image processing units are configured to form corresponding images on the surface, and are configured to be movable at least in a lateral direction relative to the surface.

The application discloses a kind of non-contact physiological signal monitoring systems based on image recognition, comprising: evoked collection module, for output light stimulation sequence and gaze guide sequence, and the high frame rate video image of the body area of target object is collected;Unit mapping module is used to construct multiple physiological response units, generate physiological response unit topology chart;Demodulation extraction module is used to perform encoding demodulation processing, generate unit evoked response feature set;Transmitting configuration module is used to construct physiological response transmission atlas;Separation correction module is used to separate and inhibit unit evoked response feature set;Inversion analysis module is used to carry out inversion, generate physiological inversion parameter set;Calibration compensation module is used to construct individual response calibration model and carry out compensation correction;Abnormal output module is used to generate abnormal monitoring result.The application multi-region image recognition, realize non-contact physiological signal monitoring.

The utility model discloses visual function adjustment training appearance and system relates to ophthalmic optics instrument technical field. A kind of visual function adjustment training appearance, including display panel and light stimulation part, the front of display panel includes the display for output visual stimulation information;The light stimulation part includes the light district at the outer periphery of display panel front, and light district is arranged with light emitting piece to radiate the light of preset wavelength for user visual, and the eyes of the user are illuminated. The utility model improves the adjustment and training effect of visual function by the synergistic effect of visual stimulation information and illumination.

The invention relates to the technical field of fluorescent probes, in particular to a cell membrane targeted near-infrared AIE fluorescent probe as well as a preparation method and application of the cell membrane targeted near-infrared AIE fluorescent probe. Dithieno [2, 3-b: 2 ', 3'-d] thiophene is adopted as a bridging structure, a triphenylamine unit is connected with a pyridinium salt unit, and the compound is specially used for targeted cell membrane localization and photodynamic tumor treatment. The near-infrared AIE fluorescent probe disclosed by the invention can be combined with a cell membrane to realize an effect of accurately and rapidly positioning cells; and under light stimulation, I-type / II-type ROS can be generated, the cell membrane structure can be destroyed, the cell membrane vacuolation can be realized, the effective killing of in-vivo and in-vitro tumor cells can be realized, and the method has important significance on tumor treatment.

To provide an image-guided variable spot light stimulation electrophysiology device applicable to structural / functional imaging and evaluation.SOLUTION: To provide an application of a device for performing image-guided functional assessment based on variable spot light stimulation of a light-activated biological sample to determine changes in functional health during disease progression and treatment. More specifically, the invention relates to the application of the device in the diagnosis of vision and neurological disorders.SELECTED DRAWING: Figure 1

Embodiments of an implantable system and apparatus for providing electrical and optical deep brain stimulation are disclosed. Through the biological introduction of light-responsive opsins to neurons, the system is operable to transform neurons into optogenetically programmable state and history-dependent logical transformers. Embedded processors of the system are operable to stimulate individual neurons using phase-shifted electrical and / or optical signals through a neural interface comprising a plurality of carbon nanotubes, then electrically and / or optically measure the neurons. Due to the parallelism and chemical superposition of the human brain, the implantable system is operable to establish a quantum-like processing ability using its neural interface.

The invention provides a photoelectron synaptic device based on a Z-type heterojunction and a preparation method and application thereof.The photoelectron synaptic device sequentially comprises a top electrode layer, a Z-type heterojunction functional layer and a bottom electrode layer from top to bottom, and the Z-type heterojunction functional layer is formed by tightly contacting a first semiconductor material layer and a second semiconductor material layer; and energy bands of the first semiconductor material layer and the second semiconductor material layer are staggered to form a Z-shaped energy band. The photoelectron synaptic device is simple in structure, the Z-type heterojunction functional layer is designed, and a plurality of synaptic behaviors are simulated by using a unique carrier recombination mechanism of the Z-type heterojunction, so that bidirectional synaptic function simulation of inhibition / excitation under the same photostimulation can be realized only through voltage switching, and the photoelectron synaptic device is applicable to various synaptic functions. And a core thought is provided for the design of a multifunctional integrated photoelectron synaptic device.

A non-image-forming visual response-based visual stimulation method and apparatus, a device, and a program product. A visual stimulation signal capable of triggering non-visual light stimulation is respectively applied to the two visual channels of a user in a time-asynchronous manner. Due to a non-image-forming visual response, the visual channel that preferentially senses the stimulation signal enables the stimulation signal to directly stimulate a corresponding sensing channel by means of photosensitive sensing cells, and image content of the stimulation signal can be sensed by the brain only after the stimulation signal is received in the other visual channel. Thus, the non-visual light stimulation generated by the light stimulation signal is time-asynchronous with a visual image stimulation, thereby reducing the mutual influence between the two processes, improving the stimulation effect of the non-visual light stimulation, and enhancing the shaping ability of the non-visual light stimulation with respect to the corresponding sensing channels.

The invention belongs to the technical field of virtual reality terminal security access control, and discloses a system for performing identity authentication on a user accessing equipment in a virtual reality terminal. In the identity authentication process, eye movement data flow information is utilized to extract pupil light reaction related information of the user, and whether the identity of the access user is matched with the claimed account of the access user or not can be efficiently judged. According to the invention, a rapid and lightweight virtual reality user identity authentication mechanism can be realized, and the requirements of the industry are met. According to the virtual reality user identity authentication method based on pupil light reaction, the pupil reaction biological characteristics of the user under light stimulation of different wavelengths are fully utilized, and high accuracy is achieved.

The invention provides a social disorder animal model construction method based on a basal lateral amygdaloid nucleus-screen nucleus neural circuit and application thereof, and belongs to the technical field of animal model construction. The method comprises the following steps: injecting a viral vector carrying a photosensitive protein gene or a photosuppressive protein gene into amygdaloid nucleus on the outer side of an animal basal to express neurons of cholecystokinin or neurons of CaMKII alpha; embedding an optical fiber above the screen-shaped core; first light stimulation is applied through an optical fiber to activate nerve projection from amygdaloid nucleus on the outer side of the substrate to the screen nucleus, and a social disorder animal model is obtained; or applying a second photostimulus to inhibit the projection, resulting in a social disorder relief animal model. According to the invention, specific photogenetic regulation and control of the BLACCK +-CLA neural circuit is realized for the first time, social behaviors can be accurately regulated and controlled without interfering with movement and anxiety levels, and a reliable experimental tool is provided for mechanism research and drug screening of social obstacles.

The invention relates to the technical field of ophthalmology medical equipment, and discloses an optical path difference regulation and control system, which comprises a light source module, an optical path regulation and control module, an optical projection module, a neural adaptation detection module and a central control module, by arranging the optical path regulation and control module and the nerve adaptation detection module, optical path difference dynamic modulation can be applied to ophthalmological treatment, the problem is solved from a nerve adaptation triggering source by changing the phase distribution mode of retina light stimulation, indirect relieving is not conducted only through intensity or frequency adjustment, and the application range is wide. Meanwhile, modulation parameters are adjusted based on the detection result of the neural adaptation detection module, so that modulation is effective and no extra discomfort is caused, feedback control closed loop is completed through the central control module, a detection-feedback-adjustment closed loop system is achieved, the modulation parameters can be dynamically optimized and adjusted according to the individual neural adaptation degree, and the modulation efficiency is improved. Therefore, the treatment individuation level can be effectively improved.

The application discloses a remote light-driven micro-soft robot and a manufacturing and operation method thereof, and can be applied to non-structural operation environments such as environment monitoring, debris search and rescue, medical diagnosis and military investigation. The micro-soft robot mainly comprises micro-nano column support legs; the movement of the micro-soft robot is determined by the micro-nano column support legs and the interaction between the micro-nano column support legs and the environment; under the irradiation of infrared light with a certain frequency, the silicon rubber driving part doped with an infrared absorption material responds to external infrared light stimulation, converts the external infrared light stimulation into heat, and promotes the silicon rubber to expand and contract, so as to provide driving force for the soft robot. The micro-soft robot has simple structure and is not limited by traditional mechanical structures, and can realize safe, effective and stable movement under remote light driving.

The application discloses a method for colorimetric and photothermal dual-mode detection of aflatoxin B1 in coffee based on MXene@Pt nanozyme, wherein MXene is obtained by etching Ti3AlC2 with LiF and HCl, dopamine carbon dots and sodium borohydride are used as reducing agents, and in-situ reduction technology is adopted to synthesize MXene nanozyme modified with platinum nanoparticles (MXene@Pt). The MXene@Pt shows peroxidase-like activity and photothermal performance enhanced by near-infrared light stimulation, can catalyze the blue deepening of the substrate 3,3',5,5'-tetramethylbenzidine (TMB) and temperature rise, and when aflatoxin B1 exists, the POD-like activity of the MXene@Pt nanozyme is inhibited, and the colorimetric and temperature signals are reduced. The colorimetric and temperature dual-mode sensor detection method for AFB1 is established, and the method has the characteristics of high sensitivity, strong specificity, simple operation, rapidness and the like.

The utility model discloses a multifunctional displayer support, and belongs to the technical field of displayer supports, the multifunctional displayer support comprises a supporting frame, a main support and an auxiliary support, the supporting frame is used for being detachably connected with an external installation structure, the main support and the auxiliary support are installed on the supporting frame, and the main support is used for installing a displayer and is provided with a plurality of clamping sleeves at intervals; a hanging lamp is arranged on the main bracket; the auxiliary support comprises a placing base. According to the utility model, the orderly arrangement of cables can be ensured through the plurality of clamping sleeves, the connection stability of cable interfaces is improved, and the use safety and the operation convenience are improved; auxiliary lighting can be provided through the hanging lamp, eye fatigue of a user caused by strong light stimulation or screen light reflection under the dark condition is avoided, and use is reliable; through the auxiliary support, the user can conveniently carry out content contrast or cross-screen cooperation and the like between different devices, the cooperative use requirement of the user for multiple devices is met, and the method is particularly suitable for a multi-task parallel working scene.

The invention relates to the technical field of electronic information, and discloses a heterojunction artificial synapse device with multi-wavelength response and bionic injury perception, which comprises a substrate, a silicon dioxide layer, a silicon-rich silicon nitride layer, a molybdenum disulfide layer and an electrode layer, the silicon dioxide layer covers the surface of the substrate, the silicon-rich silicon nitride layer is deposited on the side, away from the substrate, of the silicon dioxide layer, the molybdenum disulfide layer is transferred to the side, away from the silicon dioxide layer, of the silicon-rich silicon nitride layer, and the electrode layer is arranged on the side, away from the silicon-rich silicon nitride layer, of the molybdenum disulfide layer; and the substrate is a p-type silicon substrate. By constructing a molybdenum disulfide and silicon-rich silicon nitride heterojunction structure and optimizing material parameters and a preparation process of each layer, efficient response of the device to 350nm-380nm short-wave-band light and 510nm-550nm long-wave-band light is realized, light current generated under short-wave-band light stimulation is larger than light current generated under long-wave-band light stimulation, the multi-wavelength visual information perception requirement is met, and the device has a wide application prospect. And hardware support is provided for optical signal identification and processing in a complex environment.

This invention provides a photosensitive polyurethane film with a surface grating, its preparation method, and its applications. The photosensitive polyurethane film with a surface grating exhibits well-defined and controllable photoresponse characteristics. Its core mechanism lies in the photosensitive monomer responding to light stimulation of a specific wavelength through a dimerization reaction: under ultraviolet light irradiation, the photosensitive monomer in the film undergoes a [2+2] cycloaddition to generate a four-membered cyclobutane dimer. This response mechanism is clear, the triggering path is independent, and the response efficiency is high. It effectively overcomes the limitations of existing coumarin derivatives, which can only achieve self-healing technology. By controlling parameters such as irradiation time and number of irradiations, multi-dimensional information storage can be achieved, significantly improving information storage capacity and stability. This effectively solves the urgent problem of high-capacity information storage in the current field of optical encryption materials, providing a feasible technical path for improving the performance and expanding the practical applications of optical encryption materials.

The application provides a novel light-activated channel protein VR3.0 and uses thereof. The light-activated channel protein VR3.0 series provided in this application has a wide range of photosensitive wavelengths, higher sensitivity to light response, faster photoresponse kinetics, maintaining stable photocurrent signals under high-frequency stimulation while exhibiting good response amplitude and frequency under light stimulation of various wavelengths (especially white light, natural light). The light-activated channel protein VR3.0 series provided in this application has a clear therapeutic effect on retinal photoreceptor cell degenerative diseases, and can be used to prepare drugs for restoring the photoreceptor function of the retina, restoring the visual or photosensitive ability of subjects, and treating retinal degenerative diseases.

The invention relates to the technical field of VR visual health intervention, discloses a VR visual health intervention system and method based on dynamic visual field adaptation, and solves the problem that photostimulation of a retina target area is difficult to be continuous, accurate and free of interference when eyeballs move in a VR scene. The system comprises a VR display device, an eye movement tracking module, a dynamic view division and rendering module and a light stimulation control module. The eye movement tracking module outputs normalized fixation point coordinates in real time, the dynamic view dividing and rendering module receives and converts the normalized fixation point coordinates into real-time fixation point pixel coordinates, and each frame divides a center view, a peripheral view and a transition view with the coordinates as a reference. The photostimulation control module configures stimulation light (460-500nm blue light, 620-750nm red light and the like) based on a known photobiological effect and displays the stimulation light in a peripheral visual field. The method realizes continuous and accurate coverage of the target area through light stimulation, does not interfere with VR core experience, is flexible in parameter configuration, and is suitable for scenes such as circadian rhythm adjustment and retina health maintenance.

The utility model belongs to the technical field of medical apparatus and instruments, and particularly relates to an intraoperative eye protector; the protection part comprises a protection unit; the protection unit is symmetrically arranged on one side of the fixed part; a through hole is arranged on the fixed part; the protection unit comprises a mounting frame and a protective cover; the mounting frame is fixedly connected to the side wall of the fixed part; the mounting frame is annular in structure; the mounting frame is coaxial with the through hole and wraps the through hole; the protective cover is detachably connected to one side of the mounting frame away from the fixed part; the protective cover is a cavity structure with only one opening; the protective cover completely blocks the through hole. In the surgical process, the protection part shields the eyes of the patient, can continuously isolate the intraoperative strong light stimulation and dust impurities in the air. The eyes of the patient enter the interior of the protection part through the through hole, and intraoperative eye compression damage is effectively avoided. The mounting frame and the protective cover are detachably connected, the protective cover can be opened in the surgical process to expose the eyes of the patient, intraoperative pupil state convenient and real-time observation are realized, and the clinical surgical monitoring demand is adapted.

The application discloses a hydrogel microneedle patch with combined anti-inflammatory and hyperthermia effects, and a preparation method and application thereof. The preparation method comprises the following steps: mixing polydopamine nanoparticles loaded with drugs and a biocompatible material solution containing a photoinitiator to obtain a pre-gel solution; dropping the pre-gel solution into a mold, and then performing drying and blue light crosslinking to obtain the hydrogel microneedle patch. The polydopamine nanoparticles used are excellent photothermal agents, and have a high drug loading rate. The hydrogel microneedle patch can also be subjected to freezing strengthening treatment to improve the mechanical strength, so that the needle tip can effectively penetrate into an intervertebral disc. The hydrogel microneedle patch can effectively inhibit inflammatory reactions. Meanwhile, hyperthermia can improve the level of heat shock proteins in cells and improve the self-protection of the cells. The hydrogel microneedle patch can promote the release of drugs by near-infrared light stimulation, improve the microenvironment, and meanwhile, a suitable temperature can promote the repair of tissues, so that the hydrogel microneedle patch has a good application prospect in the treatment of intervertebral disc degeneration diseases.

The application belongs to the technical field of fluorescent analysis and detection, and particularly relates to a tridentate Schiff base compound and a preparation method and application thereof. 2 The formylhydrazine Schiff base compound is widely applied in coordination chemistry, and a parent structure thereof can be used to better study the transformation of a complex under light stimulation, and the imino group also has good photoisomerization performance, at this time, the light stimulation can catalyze the ligand to produce more rich coordination modes, so the isomerization phenomenon of the compound under the action of ultraviolet light is tested, and the application of the compound in a colorimetric chemical sensor is studied. Further research is conducted on whether the compound has different ion selectivity after the conversion configuration under the action of ultraviolet light and the change of the coordination mode, and finally, the complex of the ligand Ni 2+ , Cu 2+ metal is synthesized.

The invention discloses a multi-mode drug taking detection method and device, a storage medium and equipment, and belongs to the field of biological feature recognition. The method comprises the following steps: acquiring an eye image sequence of a detected person, which is acquired according to a time sequence; and according to the color iris information, the infrared iris information, the pupil diameter change information and the pupil shape information contained in the eye image sequence, whether the detected person takes the drug or not is judged. Wherein the eye image sequences comprise a first infrared eye image sequence, a visible light eye image sequence and a second group of infrared eye image sequences which are arranged according to a time sequence; during collection of the eye image sequences, the eyes of a detected person are subjected to continuous photostimulation for a set time through visible light in a dark environment, a first infrared eye image sequence is collected before photostimulation, a visible light eye image sequence is collected in the photostimulation process, and a second infrared eye image sequence is collected after photostimulation. According to the invention, the screening accuracy of the drug addicts is improved.