313 results about "LIGHT STIMULATION" patented technology

The present invention concerns a device and method for transmitting multiple optically-encoded stimulation signals to multiple stimulation sites, especially cell locations. The device uses a primary optical fiber to transmit specific wavelength components of an encoded light signal to output positions along the fiber where they are coupled out of the primary fiber to stimulation sites via electrodes for electrical stimulation of the sites or optical windows and / or secondary optical fibers for photo-stimulation of sites.

The present invention comprises systems and methods for stimulating target tissue comprising a light source; an implantable light conducting lead coupled to said light source; and an implantable light-emitter. The light source, lead and emitter are used to provide a light stimulation to a target tissue

The present invention concerns a device and method for transmitting multiple optically-encoded stimulation signals to multiple stimulation sites, especially cell locations. The device uses a primary optical fiber to transmit specific wavelength components of an encoded light signal to output positions along the fiber where they are coupled out of the primary fiber to stimulation sites via electrodes for electrical stimulation of the sites or optical windows and / or secondary optical fibers for photo-stimulation of sites.

A user is aroused from sleep by applying a stimulus of light to simulate dawn. The device operates to monitor movements of a sleeping subject by the use of one or more motion sensors. The detected movements are used to identify the sleep cycle timings for the user. The user can then be aroused during a light phase of sleep by timing the dawn simulator to increase to sufficient brightness to arouse the user during a light stage of sleep that is proximate to a desired wake up time.

The invention relates to a method for determining the amount of nucleic acid present in a sample, wherein:—a fluorophore is added to the sample,—fluorescence intensities emitted by the fluorophore at least two emission wavelengths in response to light stimulations at least two excitation wavelengths respectively are measured, and—the amount of nucleic acid present in the sample is deduced from the measured fluorescence intensities.

Solutions for evaluating the pupillary responses of a patient are disclosed. An illustrative method includes alternately exposing a first eye and a second eye of the patient to light stimulation in successive intervals, the light stimulation provided by at least one light source controlled by at least one computing device; concurrently capturing, with at least one image device controlled by the at least one computing device, image data of the first eye and the second eye during the exposing; and using the at least one computing device to perform the following: determine a center point of the first eye within the image data of the first eye and a center point of the second eye within the image data of the second eye; obtain image data of a first half of the first eye having an edge defined by a line of pixels intersecting the determined center point of the first eye; obtain image data of a second half of the second eye, the second half of the second eye opposing the first half of the first eye and having an edge defined by a line of pixels intersecting the determined center point of the second eye; create a composite image including the image data of the first half of the first eye and the image data of the second half of the second eye; and provide the composite image for evaluation.

An apparatus for administering light to effect re-timing of the human body clock is disclosed. In one form, the apparatus includes two pairs of light emitting diodes having an emission wavelength in the range 450 nm to 530 nm and a frame adapted to be worn on the face of a wearer. The frame is arranged to support the two pairs of light emitting diodes so that one pair of the light emitting diodes is supported adjacent a surface of each eye of the wearer. The light emitting diodes of each pair project a light output that illuminates a different area of the retina of a respective eye and are spaced apart so as to provide a viewing zone therebetween.

A light guide comb that produces a direct massage effect on the head of a user, and, moreover, uses light rays to promote cell activation of the head, cortical layer and acupuncture points, while simultaneously stimulating hair follicles to promote the health and growth of hair. The light guide comb includes an upper shell, a lower shell, a compartment, a light stimulation device and a light guide. A plurality of guide holes are defined in the upper shell to correspond to a plurality of guide pins configured on the light guide. Light rays produced by the light stimulation device disposed within the compartment are propagated through the plurality of guide pins and transmitted outward. A plurality of massage knobs are disposed on a comb head of the lower shell to provide a massage surface area greater than that of the plurality of guide pins.

A forehead-wearable light stimulator having one or more light pipes provides reliable light stimulation to a user. The stimulation can have high intensity and multiple colors. The intensity of the stimulation is less sensitive to device placement than in known light stimulators having no light pipes. The intensity is sufficient to deliver light through the eyelids, and is sufficient for the light's color to be perceived through the eyelids. The light stimulator improves on the state of the art, thereby enabling multiple new applications in the fields of biofeedback, lucid dreaming, and light-based alarms.

The present invention describes methods and devices comprising magnetic, radio frequency burst, and light stimulation to modulate muscle contraction. The magnetic stimulation may be delivered to the muscle using one or more coils that is placed transcutaneously. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal cramps and sphincter leakage.

An evaluation apparatus is taught to nondestructively characterize the electroluminescence behavior of the semiconductor-based or organic small-molecule or polymer-based light-emitting material as the finished light-emitting device functions through electroluminescence. An electrode probe is used to temporarily form a light-emitting device through forming an intimate electrical contact to the surface of the light emitting material. A testing system is provided for applying an electrical stimulus to the electrode probe and temporarily formed device and for measuring the electrical and optical / electroluminescence response to the electrical stimulus. The electrical and optical properties of the light-emitting material can be nondestructively determined from the measured response. Optionally a light stimulus is used to perform the photoluminescence characterization together with the electroluminescence characterization, and both characterizations can be performed at the same sample location or / and at the wafer level.

The present invention describes methods and devices comprising magnetic, radio frequency burst, and light stimulation to modulate muscle contraction. The magnetic stimulation may be delivered to the muscle using one or more coils that is placed transcutaneously. The methods and devices are useful to treat a number of conditions or disease conditions, including for example, gastroesophageal cramps and sphincter leakage.

The invention relates to a multi-channel light stimulation-based cochlear implant device. The device comprises a multi-channel light stimulation device, a multi-channel light pulse control circuit, a voice signal acquisition deice and a voice signal processing and encoding device, wherein the device acquires a voice signal and encodes the voice signal into a light stimulation signal; and the light stimulation signal stimulates cochlear auditory nerve through a cochlea-implanted multi-channel light pulse output port to cause nerve impulse so as to form hearing in a central nervous system. The multi-channel light stimulation-based cochlear implant solves the problem of compatibility of a stimulating electrode and biological tissue in the electronic cochlear implant and also solves the problem of mutual interference between stimulating channels caused by current diffusion in the tissue.

The invention features an optically-controlled biological device that includes a biological component comprising a non-excitable cell expressing a light-gated ion channel protein and capable of forming gap junction channels with a target cell, and an optical stimulation unit.

A soundhead of a treatment device is provided that enables a volume of tissue located beneath the soundhead to simultaneously receive ultrasound and light stimulation. According to one embodiment, the soundhead includes an ultrasound transducer, a light source, and a faceplate extending across a face of the transducer for providing a tissue contacting and ultrasound energy coupling surface of the soundhead. The faceplate is transparent or translucent to the light generated by the light source. Alternate embodiments including externally mounted light sources are also disclosed.

A soundhead of a treatment device is provided that enables a volume of tissue located beneath the soundhead to simultaneously receive ultrasound and light stimulation. According to one embodiment, the soundhead includes an ultrasound transducer, a light source, and a faceplate extending across a face of the transducer for providing a tissue contacting and ultrasound energy coupling surface of the soundhead. The faceplate is transparent or translucent to the light generated by the light source. Alternate embodiments including externally mounted light sources are also disclosed.

The invention provides an LED optical stimulation and electrographic recording integrating flexible neural electrode device and a manufacturing method thereof. The device comprises an optical stimulation electrode and a recording electrode, wherein both the optical stimulation electrode and the recording electrode comprise bottom polymer insulating layers, top polymer insulating layers and middle gold circuit layers; a plurality of holes are formed in the bottom polymer insulating layers and the top polymer insulating layers; steel pins sequentially run through the holes in the optical stimulation electrode and the recording electrode; and when the optical stimulation electrode and the recording electrode are in gluing connection, the optical stimulation electrode and the recording electrode are prevented from becoming displaced. According to the method, the optical stimulation electrode and the recording electrode are independently manufactured, and then the optical stimulation electrode and the recording electrode are bonded. According to the flexible neural electrode device disclosed by the invention, on the basis of direct contact between LED and brain tissues, light transparency is guaranteed, and meanwhile, influence on recording results due to a photoelectric effect between light and the recording electrode is effectively avoided; the electrodes, which are relatively thin, can guarantee shape preservation when attached to cerebral cortex; and the requirements of acute experiments and long-term implant experiments can be satisfied.

The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.

The invention belongs to the technical field of macromolecular biological materials, and provides a macromolecular composite self-healing hydrogel based on a molybdenum disulfide nanosheet and a preparation method thereof. The macromolecular composite self-healing hydrogel is prepared by performing photo-initiation clicking reaction in a molybdenum disulfide nanosheet water solution; the clicking reaction is generated by unsaturated double bonds in methacrylic anhydride gelatin and sulfydryl in four-branched sulfydryl polyvinyl alcohol under the radiation action of ultraviolet light. The self-healing property is realized by the material utilizing the photo-thermal conversion characteristic of the molybdenum disulfide nanosheet to heat the hydrogel under the radiation action of near-infrared light. The macromolecular composite self-healing hydrogel has the advantages that the nanometer two-dimensional material, namely the molybdenum disulfide nanosheet, is applied into the field of self-healing materials, and the quick healing characteristic of the material under the light stimulation condition is realized.

The invention provides easy handling and low cost-support equipment for measuring optical nerve-activity which is less stressful for subjects or doctors and the like. The support equipment, which provides light stimulation for subject eyes with its main body 10 fixed to the subject-head region and measures the subject optical nerve-activity, comprises a thin walled-main body 10 with a plurality of optical fibers 11 joined in the width direction; light emission regions 13a, 13b at least one of which is positioned in the main body aligned to the subject eye-position(s) and composed of a plurality of light leak parts 11c formed in peripheral surfaces of the optical fibers 11; and a connector 12a for connecting with a light emission device 12 providing light for each of the plurality of optical fibers.

An adaptive optics microperimetry, infrared beacon emits infrared light to the pupil of the subject, the Hartmann wavefront sensor measures the wavefront aberration of the human eye carried by the reflected light of the fundus, and the computer calculates the control voltage based on the measured aberration , driving the wavefront corrector to correct the aberration of the human eye. After the aberration correction is completed, the fixed optotype for fixing the line of sight of the examinee and the optical stimulation optotype for providing optical stimulation to the fundus of the examinee are displayed at a plurality of predetermined positions on the stimulus optotype display device. The pupil camera uses the infrared light emitted by the infrared light source in front of the eye to capture the subject's human eye pupil image and calculate the pupil diameter. The computer controls the change of the optical stimulus visual target according to the change of the subject's pupil diameter, and measures the subject's field of vision. The invention has high reliability, reduces the stimulus redundancy caused by the aberration of the human eye in the visual field test, is beneficial to discover early micro-perspective defects, and provides a powerful tool for the evaluation of the micro-perspective defects of the human eye and the diagnosis of related diseases.

The present invention relates to a device (30) and a corresponding method for cognitive enhancement of a user (21). For effective cognitive enhancement of the user who is going to execute a cognitive activity the proposed device comprises a light unit (31) for providing an imperceptible light stimulation to the user, and a control unit (32) for controlling said light unit (31) to provide said imperceptible light stimulation less than 5 second before the execution of a cognitive activity by the user.

The invention discloses a light control and neural information detection system. The system comprises a light stimulation control module, an electrochemical detection module, an electrophysiological detection module, a synchronous data acquisition module, a main control module and a synchronous control module, wherein the light stimulation control module can be combined with the optogenetics technology to carry out light control via laser fibers or LED lamp electrodes; the electrochemical detection module is used for detecting neurochemical signals; the electrophysiological detection module is connected with a microelectrode array and is used for detecting neural electrophysiological signals; the synchronous data acquisition module is used for synchronously acquiring neural electrochemical and electrophysiological signals; the main control module is used for carrying out synchronous coordinated control on light stimulation and neural signal detection and completing data communication; the synchronous control module is used for completing the functions of man-machine interaction, data processing, display, analysis and storage, and the like. The system can be used for solving the problems that light control and signal detection are difficult in synchronous and experiment operation is fussy in the research on neurosciences.

An eye examination device has a fundus observation system and an optical stimulation system. The optical stimulation system has an optical targeting subsystem and an optical stimulation subsystem, wherein the optical stimulation system is structured to be used to provide light stimulation to a portion of a fundus of an eye targeted by the optical targeting subsystem in conjunction with observations made with the fundus observation system.

In a device (1) for rapid pressure-freezing an aqueous sample (3), such as a biological specimen, a pressurized cooling medium can be fed into a high-pressure chamber (11) into which a sample holder (30) containing a sample (3) is inserted and which is sealed with a pressure-tight seal, to the location of the sample holder (30) held therein. The high-pressure chamber (11) comprises a viewing window structure (2) with a pressure-tight window (20), through which light can be directed from the outside onto the sample (3) located in the sample holder (30). The window (20) can comprise a transparent window element made of a high-pressure-resistant material, wherein the window element (20) is held by a pressure- and temperature-resistant window bearing provided in the high-pressure chamber.

The invention discloses a light stimulation device, which can be applied to the fields of biology, chemistry, life sciences and the like. The structure of the device is that a laser, a scanning unit and a lens are arranged sequentially and are coincident with the center of an optical axis; the center of the scanning unit is positioned on an object focal plane of the lens; and the scanning unit comprises two acousto-optic deflection devices arranged orthogonally. The device adopts the acousto-optic deflection devices as the scanning elements and can carry out high-speed random light stimulation on cell biological samples comprising nerve cells, tissues and the like so as to carry out various psychological research. The device adopts the optical fiber and the optical fiber bundle to guide light to make the system miniaturized and convenient for integration, and is very convenient to carry out cooperative work with other systems such as the microscope and the patch clamp.

A confocal microscope for performing an observation of a sample using a confocal image, the confocal microscope comprises a microscope, a confocal scanner of a Nipkow disk type, and a laser beam output section which is connected to the microscope and outputs a first laser beam for applying photic stimulation on the sample.

The invention discloses an EOG (Electrooculography)-based ERG (Electroretinography) signal acquisition and processing system and method. The system comprises a control unit, a retinal stimulator unit, an ERG signal acquisition unit and an ERG signal processing unit. The method comprises the following steps: adjusting illumination and flash rate of a stimulation light source; arranging three skin electrodes on the forehead just above eyes of a subject, on the inner sides of the eyes and the bridge of a nose and at eyelids respectively; performing dark adaptation for more than 20 minutes; aligning the eyes of the subject to the stimulation light source; acquiring an EOG signal; performing light stimulation on the eyes of the subject, synchronously acquiring the ERG signals on the inner sides of the eyes and the bridge of the nose and at the eyelids of the subject respectively, and storing after signal conditioning and AD (Analog-Digital) conversion; reading the ERG signals by an ERG signal processing and analysis unit and processing and analyzing the ERG signal. The ERG signals are acquired by using the external skin electrodes, so that the acquisition is more convenient and safer, and the cost is lower; for signal processing, the adopted method is small in operation and high in feasibility and can realize rapid signal processing.