204 results about "Ionic Channels" patented technology

The invention provides a polypeptide and application thereof in preparation of a TRPV1 inhibitor, and particularly belongs to the technical field of biomedicine. The invention provides a polypeptide which is named as Cath2, and the amino acid sequence of the polypeptide is as shown in SEQ ID NO. 1. The Cath2 can significantly inhibit activation of a TRPV1 ion channel of a mammal, inhibits TRPV1 receptors of other species including human beings in a targeted manner, and can be applied to research of TRPV1-related ion channel diseases and development of drugs. Specifically, the composition can enhance the resistance of mammals to pruritus and pain, can be used as a resource to be developed into an itching relieving product or an analgesic product and the like, and is applied to human beings and other animals to relieve pruritus and pain.

The invention discloses a high-flux high-pollution-resistance nanofiltration membrane as well as a preparation method and application thereof. The scheme is realized by constructing a gradient separation layer compounded by modified MOF and polyamide on a porous support layer; the preparation method comprises the following steps: preparing a water phase from modified MOF grafted with carboxylate radical and sulfonate ion recognition groups on the surface, a polyamine monomer and an ion channel regulator, carrying out interfacial polymerization on the water phase and an oil phase containing a fluorine-containing acyl chloride monomer on the surface of a porous support membrane, and carrying out heat treatment and metal ion post-treatment, the modified MOF in gradient distribution in the nanofiltration membrane can specifically adsorb Ca < 2 + >, Mg < 2 + > and other scaling ions, and scale formation is inhibited from the source; the composite structure simultaneously realizes high flux and high selectivity; the retention rate of the membrane to Na2SO4 under 0.6 MPa is greater than or equal to 99.2%, the retention rate of the membrane to NaCl is less than or equal to 15%, the flux of pure water is greater than or equal to 20 L.m <-2 >. H <-1 >. Bar <-1 >, and the flux attenuation rate is less than or equal to 16.7% after the membrane runs in high-hardness, high-COD and high-salinity wastewater for 120 hours; the scheme is particularly suitable for zero-discharge pretreatment of high-salinity wastewater such as solid waste percolate with the TDS of 5-30% and chemical engineering.

The invention discloses a microphase separation hydrogel electrolyte with ion selectivity and a preparation method and application thereof. The electrolyte is prepared by constructing a microphase separation polymer network composed of a polyanionic polymer and an ion exchange group-containing polymer in a synergistic manner and inducing crosslinking by using metal ions. The formation of a continuous ion transmission channel in the hydrogel is realized. The technical problem that high ionic conductivity and high ionic transference number are difficult to obtain at the same time in a traditional hydrogel electrolyte is solved, spatial unwrapping and selective coordination of a polymer chain segment are induced through a microphase separation structure, and directional construction of an ion channel is achieved; and the ion conductivity of the electrolyte is remarkably improved, and meanwhile, the target ion transference number is further improved. The prepared hydrogel electrolyte has high mechanical stability, high ion flux and excellent ion selectivity, and can be widely applied to high-performance electrochemical devices such as batteries.

Manufacturing structure for a positive electrode plate provided with a positive electrode suspension by electrostatic adhesion, wherein the positive electrode plate comprises a positive electrode substrate and a layer of positive electrode suspension adhering thereto; the positive electrode suspension consists of a material that remains solid at room temperature; the positive electrode suspension is produced independently without needing to be mixed with the positive electrode substrate during the manufacturing process; the positive electrode substrate and the positive electrode suspension can be produced separately; the positive electrode suspension is solvent-free, solid, and has a long shelf life; and the manufacturing structure of the positive electrode plate provided with the positive electrode suspension by electrostatic adhesion comprises: a raw material tank for receiving the positive electrode suspension material; and The positive electrode mass material comprises the following: a multitude of positive electrode particles that can store or release lithium ions; the positive electrode particles constitute an active material; and A variety of PEOs (polyethylene oxides) serve to guide lithium ions and increase the conductivity of the positive electrode for lithium ions; the PEOs are thermoplastic, therefore they melt at high temperatures and are in a molten state; and a variety of PVDFs (polyvinylidene fluoride) or PVDF-HFPs (vinylidene fluoride-co-hexafluoropropylene); the PVDFs or PVDF-HFPs and the PEOs are polymer materials; when the positive electrode suspension is heated to a specific temperature, a copolymer of the PEOs and the PVDFs or PVDF-HFPs melts in the positive electrode suspension, causing the positive electrode suspension to become sticky; the sticky positive electrode suspension adheres to the positive electrode substrate, thus forming the positive electrode plate; and a variety of conductivity agents to increase the electrical conductivity of the positive electrode suspension; and a variety of lithium salts for the lubrication of the polymer chains of the polymer material and for increasing the ionic conductivity; and a variety of ceramic particles for guiding the lithium ions and forming lithium ion channels to prevent side reactions between the lithium ions and the positive electrode suspension due to abnormal deposition of lithium ions in the positive electrode suspension; and a variety of positive electrode particles, ceramic particles, conductivity agents and lithium salts, which are dispersed in the polymer material and support the positive electrode suspension; and The positive electrode material remains a solid at room temperature; when the positive electrode material is heated to a specific temperature between 50°C and 240°C, the PEOs in the positive electrode material melt, so that the positive electrode material adheres to the positive electrode substrate and forms the positive electrode plate; and An electrostatic spray gun is connected to the raw material container and serves to hold the positive electrode suspension. It applies a voltage to the suspension, generating electrostatic charges on its surface and forming charged fine particles. These charged fine particles are sprayed from the spray gun's outlet. At the outlet of the spray gun, a roller conveyor mechanism advances a carrier plate. This carrier plate collects the charged fine particles sprayed from the outlet and distributes them onto the substrate of the positive electrode to form a first electrode plate. The carrier plate consists of a metal sheet; and Since each particle of the positive electrode material is extremely small, the particles electrostatically adsorb to one another when the positive electrode material is sprayed onto the substrate using an electrostatic spray gun, thus forming a high layer density. This creates the positive electrode plate with high energy density, and the lithium-ion conductivity is further increased. Upon contact of the charged fine particles with the metal sheet, an electrostatic attraction arises between the charged fine particles and the metal sheet, causing the charged fine particles to adhere to the metal sheet and form the first electrode plate. a heating element connected to the roller belt mechanism, serving to heat the first electrode plate so that the charged fine particles are converted into a molten material and adhere to the positive electrode substrate to form the positive electrode plate; and Since the positive electrode plate with the positive electrode mass layer formed from the positive electrode mass material does not require baking and rolling steps, the materials inside the positive electrode mass material are not damaged by thermal or mechanical stresses.

The invention belongs to the technical field of battery manufacturing, and provides a positive pole piece of a lithium-manganese dioxide battery and a manufacturing process and application of the positive pole piece. A polymer ion channel coating is arranged on the surface of a positive active layer of the positive pole piece; and the polymer ion channel coating contains a polymer ion channel with a porous structure. By forming the ion channel layer with the porous structure on the surface of the positive electrode, the wettability of the surface of the positive electrode plate to electrolyte can be improved while the stability of the positive electrode is maintained. Moreover, the reaction activity of a polymer ion channel is low, the polymer ion channel cannot react with a positive electrode active substance in the positive electrode or an electrolyte and the like generally, the stability is good, the problem that electrolyte on the surface of the positive electrode volatilizes quickly under the long-term high-temperature condition of a primary battery can be better solved through coating and film forming, and the electrolyte wettability of the surface of the positive electrode is more effectively improved.

A device for activating the mitochondrion, wherein negative charge and reactive oxygen are delivered from outside to the mitochondrion via a negative charge and reactive oxygen delivery unit to serve as material for the mitochondrial redox reaction; and, wherein a calcium ion channel stimulation unit can stimulate an in vivo calcium ion to transport a protein across a calcium ion on an inner membrane of the mitochondrion into a matrix space of the mitochondrion, whereby an influx of the calcium ion promotes the depolarization of the mitochondrion and increases the activity of mitochondrial oxidative phosphorylation.

The invention discloses an ion channel protein near-atomic scale confinement dissolution electrochemical machining method based on a bionic confinement interface. The method is characterized in that a bionic phospholipid bilayer mask is spread on a workpiece anode to shield a non-processing area, ion channel protein is embedded into the bionic phospholipid bilayer mask to serve as an electrolyte channel, and when the bionic phospholipid bilayer mask is powered on, the anode dissolution reaction is strictly limited in the ion channel protein channel. Millivolt-level picosecond-nanosecond pulse voltage or current is adopted on the time scale so that anode metal atoms can be removed one by one, electrolytic products are discharged in the modes of electrolyte adjustment, microcosmic acting force, micro vibration and the like so as to ensure sustainable generation of electrochemical reaction, and therefore near-atomic-scale electrolytic machining is achieved. The electrochemical machining technology and the biological field are fused in an interdisciplinary mode, the near-atomic-scale electrochemical dissolution reaction space is constructed, the capacity of electrochemical machining for removing materials in an ion form is approached, and near-atomic-scale electrochemical machining is achieved.

The application belongs to the technical field of biological medical materials, and discloses a polydopamine modified modified nano-graphyne and a preparation method and application thereof. In the method, the polydopamine coating is combined with the nano-graphyne for the first time to construct a GDY@PDA composite system, and the core defects of the blocky graphyne, such as easy agglomeration, poor water solubility and insufficient biocompatibility, are solved. The graphyne-based material is applied to the near-infrared two-region photothermal regulation of neural cell calcium influx for the first time, the calcium ion channel is activated through the local thermal effect of the material, and precise, remote and reversible calcium influx regulation is realized; the limitation that the traditional biocompatibility modification is easy to fall off and difficult to functionalize is broken through, the polydopamine modification makes the material have both photothermal efficiency and biological safety, and the application of the graphyne in the treatment of neural diseases (such as neural cell injury repair) is expanded.

An ion separation device comprising a plurality of plates, wherein each of the plates has one or more apertures therethrough and at least one electrode around each of the one or more apertures, and wherein the plates are arranged so that the one or more apertures and electrodes are aligned to form a plurality of ion channels that extend through each of the plates. The device also comprises one or more voltage supplies for applying voltages to the electrodes for causing ions to be separated in the plurality of channels according to mass to charge ratio or mobility.

Provided herein are a humanized anti-alpha-2-delta-1 monoclonal antibody and an application thereof. Specifically provided is a humanized antibody, or a biologically active fragment derived from the antibody, that binds to a voltage-gated calcium channel alpha-2-delta-1 subunit (subtype 5). The antibody or the biologically active fragment derived from the antibody, either alone or in combination with lenvatinib, is capable of significantly inhibiting the self-renewal capacity of liver cancer cells and the growth of transplanted tumors in animals. The antibody, either alone or in combination with lenvatinib, can be used for a combination of liver cancer drugs targeting liver cancer stem cells, and can also be used for the in vivo diagnosis of alpha-2-delta-1+ tumors.

The invention belongs to the field of biological medicine, and relates to application of a TRPV4 inhibitor in preparation of a medicine for preventing or treating diseases caused by trimethyltin chloride poisoning. The TRPV4 ion channel inhibitor can remarkably prolong the incubation period of epilepsy caused by trimethyltin chloride poisoning, relieve the severity of epileptic seizure, improve nerve injury and increase the survival rate. Therefore, a new drug target is provided for diagnosis of trimethyltin chloride poisoning and drug research and development, and a new strategy is provided for clinical treatment of trimethyltin chloride poisoning.

Fused heteroaryl compounds and compositions useful for preventing and / or treating a disease or condition related to aberrant function of voltage-gated sodium ion channels, e.g., an abnormal, delayed / persistent sodium current. Treatment methods for a disease or condition related to aberrant function of sodium ion channels are also provided herein, including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders.

Mathematical parameters can be obtained to analyze the state of ion channels. [Solution] The ion current data generation device 7 includes a data generation unit 80 that generates first data 41 indicating the ion current I based on mathematical parameters 71 set as data indicating the ion current I flowing through the ion channel 10 and the frequency characteristics of a detection unit 20 that measures the ion current I.

The present disclosure relates generally to small molecule modulators of ion channels and their use as therapeutic agents.

The present disclosure provides, inter alia, an engineered molecule and methods for treating or ameliorating an inherited ion channelopathy, such as Brugada syndrome, or Dravet syndrome, in a subject. Further provided are methods for regulating an ion channel density and ion influx thereof by the engineered molecule disclosed herein.

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R1, R2, R3, R12, and L are as defined herein. The compounds are antagonists of the resistant (R-type) voltage-gated calcium ion channel Cav 2.3. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in the treatment of diseases modulated Cav 2.3, including epilepsy, neurodegenerative conditions such as Parkinson's disease, focal, drug-resistant forms of epilepsy, and other neurological disorders such as developmental and epileptic encephalopathies and Phelan-McDermid and Fragile X syndromes.

The invention discloses a polysubstituted cyclopropyl carbonyl compound with calcium ion channel regulation activity as well as a pharmaceutical composition and application thereof, and belongs to the technical field of medicines. An alpha-chlorocyclobutanone compound is used as a raw material and reacts with aryl magnesium bromide with different substituent groups in an organic solvent, and the polysubstituted cyclopropyl carbonyl compound is obtained in one step. The polysubstituted cyclopropyl carbonyl compound is novel in structure, the preparation method has the advantages of being low in cost, simple and convenient to operate, mild in condition and the like, and the polysubstituted cyclopropyl carbonyl compound novel in structure can be rapidly obtained. The prepared cyclopropyl carbonyl compound has T-type calcium channel regulation activity and has an analgesic effect.

The invention relates to potassium ion channel inhibitor compounds having improved affinity and selectivity for Kv1.3 ion channel, and enhanced stability. The inhibitor compounds comprise a polypeptide component which is a miniprotein. The invention also relates to therapeutic indications and diagnostic uses of the inhibitor compounds.

The invention discloses traditional Chinese medicine combined powder for rapidly treating various burns and scalds, and relates to the technical field of traditional Chinese medicine formulas. Traditional Chinese medicine combined powder for rapidly treating various burns and scalds is characterized in that the active ingredients of the powder comprise 6-10 parts by weight of polygonum cuspidatum, 3-9 parts by weight of coptis chinensis, 4-10 parts by weight of paris polyphylla, 6-12 parts by weight of rhizoma bletillae, 15-30 parts by weight of calcined dens draconis, 3-9 parts by weight of spar and 0.1-0.3 part by weight of pearl. The combined medicine powder has the effects of clearing away heat and toxic materials, promoting tissue regeneration, relieving pain, promoting wound repair and enhancing local microcirculation of the wound, the medicine powder generally needs to be combined with sesame oil for use, the core components of the medicine powder, namely polygonum cuspidatum and coptis chinensis, synergistically exert broad-spectrum antibacterial and antioxidant effects, and paris polyphylla and rhizoma bletillae enhance the barrier function of the wound; the calcined dens draconis and the kyanite promote activation of a calcium ion channel, and the pearl can regulate and control ordered deposition of collagen and reduce scar hyperplasia.

The invention discloses a non-sterilization type mildew-proof and antibacterial material capable of dynamically responding to thallus proliferation as well as a preparation method and application of the non-sterilization type mildew-proof and antibacterial material. The material comprises polyvinyl alcohol, carboxymethyl cellulose or a salt thereof and metal ions, and the polyvinyl alcohol, the carboxymethyl cellulose or the salt thereof are bridged through the metal ions; the metal ions comprise Li < + >. The material disclosed by the invention takes Na < + > released by thallus proliferation as a signal medium, releases Li < + > as required through a coordination-dissociation process, and further induces thallus cells to actively ingest Li < + > through metabolic deception of occupying a potassium ion channel by utilizing a hydration radius of Li < + > similar to K < + > according to the metabolic demand of sodium excretion and potassium ingestion in the thallus proliferation process; on one hand, bacterial cell replication lacks essential nutrient substance K < + >, and finally gradually declines; on the other hand, protein space conformation is changed and inactivated by capturing water molecules of intracellular protein, and the two aspects have a synergistic effect, so that the efficient mildew-proof and antibacterial effects of Li < + > at low concentration can be realized, and the effect is lasting.

The invention belongs to the technical field of biomedical materials, and discloses polydopamine modified nano graphdiyne as well as a preparation method and application thereof. According to the method, a polydopamine coating is combined with nano graphdiyne for the first time, a GDY and PDA composite system is constructed, and the core defects that blocky graphdiyne is prone to agglomeration, poor in water solubility and insufficient in biocompatibility are overcome. The graphdiynyl material is applied to near-infrared two-region photo-thermal regulation and control of nerve cell calcium internal flow for the first time, a calcium ion channel is activated through the local warming effect of the material, and accurate, remote and reversible calcium internal flow regulation and control are achieved; the limitation that traditional biocompatibility modification is easy to fall off and difficult to functionalize is broken through, the material has photo-thermal efficiency and biological safety through polydopamine modification, and the application of graphdiyne in nerve disease treatment (such as nerve cell damage repair) is expanded.

The present invention relates to a structure for a biosensor, a biosensor including the same, and a method for real-time nicotine analysis in saliva using the biosensor. According to the present invention, a structure connected to an electrode of a biosensor forms a structure of a crystalline carbon membrane / calcium ion-selective membrane / TRPA1-containing nanovesicle. When nicotine is contained in saliva containing calcium ions, the nanovesicle having a TRPA1 ion channel in the outermost layer of the structure specifically reacts with the nicotine contained in the saliva to introduce calcium ions. The resulting change in calcium ion concentration changes the surface potential of the crystalline carbon membrane in contact with the calcium ion-selective membrane through the calcium ion-selective membrane. By measuring the change in electrical conductivity, such as the change in open-circuit voltage, nicotine can be detected even in minute amounts of 1 pM, thereby allowing for the quantitative determination of the nicotine concentration in a smoker's saliva in real time.

The application discloses an integrated polybenzimidazole gradient membrane and a preparation method and application thereof. The preparation method comprises the following steps: applying a first solution containing polybenzimidazole, a polar solvent and a small-molecule sacrificial template to a substrate surface, removing the polar solvent, forming a dense small-molecule solvated polymer support layer, applying a second solution containing polybenzimidazole and a polar solvent to the surface of the small-molecule solvated polymer support layer, removing the polar solvent to form a screening layer, and fusing the small-molecule solvated polymer support layer and the screening layer to form an integrated structure, thereby obtaining an integrated polybenzimidazole membrane. In-situ etching treatment is performed to obtain an integrated polybenzimidazole gradient membrane. According to the application, a high-selectivity separation thin layer is constructed on the surface of the polymer support layer, the hydrophilic narrow ion channel size can ensure ion screening, the trade-off effect of conductivity and selectivity is broken through, and the membrane has high ion conductivity, high mechanical property, high ion selectivity and high stability.

The invention discloses a liquid crystal elastomer composite material and a preparation method thereof, and relates to the technical field of liquid crystal elastomers. The method comprises the following steps: firstly, synthesizing an ionic liquid functionalized liquid crystal monomer containing double bonds through a multi-step reaction; then preparing a UiO-66 type metal organic framework material, and sequentially performing amination, maleic anhydride modification and lithium salt adsorption to obtain modified MOFs; and finally, carrying out dispersion reaction on an ion functionalized liquid crystal monomer, the modified MOFs, a cross-linking agent, a photoinitiator and a catalyst in tetrahydrofuran to obtain a liquid crystal oligomer dispersion liquid, casting, drying to form a film, and carrying out stretching orientation and ultraviolet light cross-linking curing to obtain the final composite material. The method has the advantages that a continuous ion transmission path is constructed on the molecular level through chemical bond grafting, meanwhile, a macroscopic ion channel is provided by utilizing the porous MOFs material, and the ionic conductivity of the material is remarkably improved through the synergistic effect of the two.

The present application relates to the field of lithium ion battery silicon negative electrode material. The existing lipoic acid biological binder depends on water phase coordination, and is easy to fail in organic electrolyte. The polysulfide lipoic acid homopolymer has too strong flexibility, lacks polar functional groups, has low bonding strength, and cannot stabilize the electron / ion channel. The present application provides a kind of dynamic self-repairing polymer binder, which is prepared by polymerization reaction of a multivariate copolymer containing vinyl unsaturated carboxylic acid monomer, unsaturated amide monomer and sulfur-containing compound containing cyclic disulfide structure. The binder uses dynamic disulfide bond response volume change stress, dissipates stress and repairs microcracks through reversible fracture / recombination; the polar group forms multiple interactions with active material and current collector, enhancing the interface adhesion; the dynamic coordination characteristics optimize ion transmission. Experimental results show that the electrode exhibits excellent cycle stability, mechanical integrity and rate performance, effectively solving the failure problem caused by volume expansion of silicon negative electrode.

The invention provides an application and a method of GSH in promoting mature differentiation of hiPSC-CMs, and the method is characterized in that in the process of directionally differentiating the hiPSC-CMs into the hiPSC-CMs, an effective dose of GSH is added into a differential medium, and the optimal concentration is 20-100 [mu] M. According to the invention, through simple and economical exogenous supplement of GSH, maturation of hiPSC-CMs is systematically promoted from multiple dimensions, including enhancement of intracellular anti-oxidation defense capability; energy metabolism is promoted to be converted from glycolysis to oxidative phosphorylation; up-regulating expression of cardiac muscle cell specific structural protein and calcium ion channel related genes; mitochondrial biological generation and functions are promoted; and the cell morphological structure is induced to develop to a mature phenotype. The method is simple and convenient to operate and high in biocompatibility, the hiPSC-CMs with mature functions can be stably obtained, and a high-quality cell source is provided for application of the hiPSC-CMs in the fields of heart disease modeling, drug cardiotoxicity screening and the like.

The present application provides a method for regulating calcium ion influx of myocardial cells by modifying any one or more of the amino acid residues in the combination of ESSE at positions 2061-2064 in the amino acid sequence corresponding to SEQ ID No. 1 of the mammalian L-type calcium channel protein, and a calcium channel regulator. The present application also provides a pharmaceutical composition for treating cardiovascular diseases, which comprises a regulator of any one or more of the amino acid residues in the combination of ESSE at positions 2061-2064 in the amino acid sequence corresponding to SEQ ID No. 1 of the mammalian L-type calcium channel protein. The present application also provides a method for screening potential substances for treating cardiovascular diseases.

The present application relates to waste landfill treatment technical field, disclose a kind of sludge and fly ash mixed filling treatment process, comprising: porous medium composite adsorption medium preparation, ion exchange pre-activation modification, osmotic pressure gradient layer construction, electrochemical activation field formation, ion channel dredging treatment, osmotic pressure self-repairing adjustment, electrochemical self-cleaning maintenance and other steps.The present application is through the synergistic effect of porous medium reinforced osmosis adsorption and ion exchange pre-activation, combined with osmotic pressure gradient directional migration and electrochemical activation, realize the efficient removal and long-term stable treatment of heavy metal pollutants, high heavy metal removal rate, long stable operation period of landfill system, reduce artificial, effectively reduce environmental pollution risk.

The application discloses a KCR1 mutant suitable for plant potassium ion homeostasis regulation and application thereof, relates to the technical field of bioengineering, and the KCR1 mutant has at least T136A and G140A mutations on the basis of a light-controlled potassium ion channel protein KCR1. The application also discloses a gene encoding the KCR1 mutant. The application also discloses application of the KCR1 mutant or the gene in plant culture, breeding of new plant varieties or preparation of plant culture products. The KCR1 mutant has a blue-shifted excitation spectrum compared with a wild type, and can realize precise regulation of plant potassium ion flow through light regulation, and has great application value in light-controlled plant breeding and research of plant potassium ion channels.

The invention discloses conductive hydrogel as well as a preparation method and application thereof, and relates to the technical field of conductive hydrogel materials. The preparation method comprises the following steps: dispersing nanocellulose into a hydrophilic and hydrophobic monomer precursor solution, adding an amphiphilic monomer, inducing microphase separation by utilizing thermodynamic incompatibility, and carrying out thermal initiation polymerization. The hydrogel is internally provided with a micro-phase separation structure formed by self-assembly, and nanocellulose is distributed on a phase interface to form a continuous ion channel. Through microstructure regulation and control, the mechanical strength, toughness and ionic conductivity of the material are effectively coordinated, and meanwhile, the material is endowed with excellent water-retaining property and environmental stability. The preparation process is simple and does not need complex equipment. The conductive hydrogel is particularly suitable for being used as a negative electrode friction layer of a friction nano-generator, can remarkably improve the charge transfer efficiency and the device output performance, and has important application value in the fields of flexible electronics, intelligent sensing and the like.