361 results about "Ionic Channels" patented technology

The invention relates to the field of medicines. Specifically, the invention relates to a voltage-gated calcium channel alpha2delta subunit ligand containing a polycyclic gamma-aminobutyric acid structure as shown in a general formula I, a preparation method of the voltage-gated calcium channel alpha2delta subunit ligand and application of the voltage-gated calcium channel alpha2delta subunit ligand to treatment of chronic neuropathic pain, epilepsy and anxiety. # imgabs0 #

The invention relates to a composite diaphragm with high ionic conductivity, a composite solid electrolyte and a preparation method thereof. The composite diaphragm is composed of a lithium lanthanum-based fluorine-doped solid electrolyte LLMOF and a base membrane, the chemical general formula of the LLMOF is Li < x > La < y > M < 1 > < z > M < 2 > < w > M < 3 > O < 6 > F, wherein M1 is a tetravalent cation, M2 is a pentavalent cation, and M3 is a hexavalent cation; 1 < x + 3y < 5, 0 < x < = 2, and 1 / 3 < y < 5 / 3; 0 < = z < = 2, 0 < = w < = 2, 0 < = u < = 2, z + w + u = 2; the base membrane is a large-aperture base membrane, and the aperture r is more than or equal to 200nm and less than or equal to 1mu m; the particle size D50 of the LLMOF is 50 nm to 1 [mu] m, and the particle size D50 of the LLMOF is less than or equal to the aperture r of the base film. According to the composite diaphragm disclosed by the invention, the LLMOF solid electrolyte with an ion channel function is introduced, so that efficient conduction of ions is realized; the particle size is matched with that of a large-aperture base membrane, the membrane can be uniformly embedded into membrane holes, a continuous conduction path is constructed, and the ionic conductivity is improved; meanwhile, the composite diaphragm has excellent thermal stability and interface wettability, interface impedance is effectively reduced, and growth of lithium dendrites is inhibited.

The invention relates to application of an MYZAP overexpression vector in preparation of a medicine for preventing and treating MIRI, and belongs to the technical field of biological medicine. In order to solve the problem that application of gene drugs in prevention and treatment of myocardial ischemia reperfusion injury is limited, the invention provides application of an MYZAP gene overexpression recombinant vector in preparation of drugs for prevention and treatment of myocardial ischemia reperfusion injury, and the MYZAP gene overexpression recombinant vector is an adeno-associated virus vector AAV9-MYZAP for overexpressing MYZAP. Experiments prove that MYZAP overexpression can improve the cardiac function after myocardial ischemia reperfusion, reduce the occurrence rate of arrhythmia and improve the functions of sodium ion channels, potassium ion channels and calcium ion channels of myocardial cells. On the basis, the invention further provides a medicine for preventing and treating myocardial ischemia reperfusion injury, a new strategy is provided for gene therapy of myocardial ischemia reperfusion injury, and the medicine has a wide clinical application prospect.

The present invention discloses a method for preparing a high-ionic conductivity cement-based structured electrolyte and the electrolyte, comprising: mixing a polymer solution, cement, and fine sand to obtain a polymer-cement slurry; subjecting the polymer-cement slurry to low-temperature, sealed curing, and then allowing it to stand at room temperature to obtain a cement-based structured electrolyte. The present invention utilizes a controlled phase separation technique to enable elastic phase separation of the polymer network prior to cement hydration. During the hydration process, the cement adaptively forms the backbone of the polymer network, resulting in a good interface between the two, capable of forming continuous, high-conductivity ion channels. The preparation process is simple to operate and highly reproducible.

The invention relates to the technical field of waste landfill treatment, and discloses a sludge and fly ash mixed filling treatment process which comprises the steps of porous medium composite adsorption medium preparation, ion exchange pre-activation modification, osmotic pressure gradient layer construction, electrochemical activation field formation, ion channel dredging treatment, osmotic pressure self-repairing adjustment, electrochemical self-cleaning maintenance and the like. According to the method, efficient removal and long-term stable treatment of heavy metal pollutants are achieved through the synergistic effect of porous medium enhanced permeation adsorption and ion exchange pre-activation in combination with osmotic pressure gradient directional migration and electrochemical activation, the heavy metal removal rate is high, the landfill system stably operates for a long time, manpower is reduced, and the environmental pollution risk is effectively reduced.

The invention provides a polypeptide and application thereof in preparation of a TRPV1 inhibitor, and particularly belongs to the technical field of biomedicine. The invention provides a polypeptide which is named as Cath2, and the amino acid sequence of the polypeptide is as shown in SEQ ID NO. 1. The Cath2 can significantly inhibit activation of a TRPV1 ion channel of a mammal, inhibits TRPV1 receptors of other species including human beings in a targeted manner, and can be applied to research of TRPV1-related ion channel diseases and development of drugs. Specifically, the composition can enhance the resistance of mammals to pruritus and pain, can be used as a resource to be developed into an itching relieving product or an analgesic product and the like, and is applied to human beings and other animals to relieve pruritus and pain.

The invention relates to an anti-fatigue refreshing functional chewing gum containing natural active ingredients, which relates to the technical field of food, and comprises a gum base, a natural sweetening agent and an active ingredient mixture, the mustard extract and coffee are innovatively combined to form a dual-channel nerve activation mechanism, the mustard extract realizes instant refreshing through a targeted oral trigeminal nerve TRPA1 ion channel, caffeine maintains continuous excitation through antagonism of a central adenosine receptor, and the space-time cooperation of the mustard extract and the coffee breaks through the limitation of a single path. Meanwhile, a rhodiola rosea extract, a sea-buckthorn extract, an American ginseng extract and astragalus polysaccharide are compounded, so that a triple anti-fatigue physiological barrier with functions of nerve regulation, oxidative stress inhibition and energy metabolism optimization is formed. In the preparation process, a microcapsule embedding technology is adopted to control slow release of mustard active ingredients, menthol flavor is combined to synergistically trigger TRP channel dual activation, and unification of efficacy and palatability is achieved.

The invention discloses a high-flux high-pollution-resistance nanofiltration membrane as well as a preparation method and application thereof. The scheme is realized by constructing a gradient separation layer compounded by modified MOF and polyamide on a porous support layer; the preparation method comprises the following steps: preparing a water phase from modified MOF grafted with carboxylate radical and sulfonate ion recognition groups on the surface, a polyamine monomer and an ion channel regulator, carrying out interfacial polymerization on the water phase and an oil phase containing a fluorine-containing acyl chloride monomer on the surface of a porous support membrane, and carrying out heat treatment and metal ion post-treatment, the modified MOF in gradient distribution in the nanofiltration membrane can specifically adsorb Ca < 2 + >, Mg < 2 + > and other scaling ions, and scale formation is inhibited from the source; the composite structure simultaneously realizes high flux and high selectivity; the retention rate of the membrane to Na2SO4 under 0.6 MPa is greater than or equal to 99.2%, the retention rate of the membrane to NaCl is less than or equal to 15%, the flux of pure water is greater than or equal to 20 L.m <-2 >. H <-1 >. Bar <-1 >, and the flux attenuation rate is less than or equal to 16.7% after the membrane runs in high-hardness, high-COD and high-salinity wastewater for 120 hours; the scheme is particularly suitable for zero-discharge pretreatment of high-salinity wastewater such as solid waste percolate with the TDS of 5-30% and chemical engineering.

Disclosed in the present application are a compound as represented by formula (I), a pharmaceutically acceptable salt, a stereoisomer, a tautomer, or an N-oxide, and the use thereof in the preparation of a drug for treating, preventing or alleviating voltage-gated sodium ion channel-related diseases.

The application provides a mixed matrix membrane for efficient ion separation and a preparation method thereof, and belongs to the technical field of separation membranes.The application mixes an aluminum salt and sodium hydroxide in an organic solvent, then adds a heterocyclic organic ligand containing nitrogen to obtain a MOF precursor solution; adds polyimide into the MOF precursor solution to obtain a casting solution; pours the casting solution into a mold and performs vacuum heating, then performs peeling, soaks in ethanol, and then performs drying to obtain the mixed matrix membrane for efficient ion separation.The application realizes uniform dispersion of MOF-303 in the whole matrix by controlling the MOF loading, and constructs continuous ion channels by the uniformly dispersed MOF-303 crystal structure, so that the selectivity of the membrane to monovalent ions is further improved.The operation is simple, and the cost is low.

The present invention relates to a novel class of bicyclic derivatives that function as small-molecule KCQN2 / 3 (Kv7.2 / 3) potassium channel activators, along with their pharmaceutical composition, method of preparation, and therapeutic applications. These compounds, represented by Formula (I), and defined by specific substituents and structural characteristics as described in the specification. By modulating or enhancing the activation of Kv7.2 / 3 potassium channels, these derivatives hold therapeutic potential for treating seizure disorders and other conditions influenced by potassium ion channel modulation.

Specifically, firstly, montmorillonite (MMT) powder is stripped into a nanosheet layer by using an ultrasonic dispersion technology, a two-dimensional layered structure of the nanosheet layer forms rich nanoscale ion channels, and an efficient path is provided for ion directional migration in salinity gradient power generation; meanwhile, after the cellulose is stripped and dispersed by a DMSO solution, a uniform polymer network is formed, the uniform polymer network is used as a substrate material to improve the mechanical strength of the film, and the interfacial ion adsorption and conduction capability is optimized through hydrophilic groups. When the MMT nanosheet and the cellulose suspension are mixed, the MMT nanosheet and the cellulose suspension form an interpenetrating network structure through physical winding and electrostatic interaction, ordered stacking is achieved through vacuum filtration, and finally the composite film with both ion selectivity and structural stability is formed on the substrate. The preparation process is high in material adaptability, green and controllable in preparation process, high in competitiveness in large-scale production and practical application and beneficial to popularization.

The invention discloses a KCR1 mutant suitable for plant potassium ion steady state regulation and application thereof, and relates to the technical field of bioengineering, and the KCR1 mutant at least has T136A and G140A mutations on the basis of light-operated potassium ion channel protein KCR1. The invention also discloses a gene for coding the KCR1 mutant. The invention also discloses application of the KCR1 mutant or gene in plant culture, cultivation of new plant varieties or preparation of plant culture products. The KCR1 mutant disclosed by the invention has a blue-shift excitation spectrum compared with a wild type, can realize accurate regulation and control of plant potassium ion flow through illumination regulation and control, and has a relatively great application value in the aspects of light-controlled plant cultivation, plant potassium ion channel research and the like.

The invention provides a milk protein peptide which takes milk protein as a raw material and has the effects of promoting calcium absorption and improving bone health and application of the milk protein peptide. Specifically, milk protein peptide sequences, including YGGVSL and SQRY, are screened by adopting enzymolysis, sequence identification and molecular docking methods. The milk protein peptide is proved to have high calcium transport promoting capacity in the in-vitro intervention of Caco-2 cells, and the milk protein peptide is proved to have the capacity of promoting osteogenesis and inhibiting bone resorption in the in-vitro intervention of MC3T3-E1 mouse embryo osteoblasts. In animal experiments, by increasing the content of blood calcium and bone calcium, reducing the content of excrement calcium, improving mRNA expression of calcium ion channel protein, calcium binding protein and peptide transporter in intestinal tracts, enhancing the efficiency of calcium entering blood, promoting osteogenesis and inhibiting bone resorption, the milk protein peptide is comprehensively proved to have the capabilities of improving calcium resorption of organisms and improving bone health. The milk protein peptide has both functionality and nutrition, and has a wide application prospect in the aspect of bone health.

The invention provides a pharmaceutical composition and application thereof in preparation of a compound preparation, and belongs to the field of medicines. The pharmaceutical composition comprises a potassium ion channel opener, a 5 alpha-reductase inhibitor and a phosphodiesterase 5 inhibitor. The pharmaceutical composition can synergistically promote treatment of androgen dependent diseases or prevention of complications, and by taking the pharmaceutical composition of minoxidil, finasteride and tadalafil as an example, the effects in a benign prostatic hyperplasia rat model and an androgenic alopecia mouse model are verified, which indicates that the minoxidil, finasteride and tadalafil have a synergistic interaction effect, and the pharmaceutical composition can be used for treating the androgen dependent diseases or preventing the complications. Good clinical application prospects are realized.

The invention relates to the field of sensors for realizing an ionic migration confinement effect by using silicon dioxide, and discloses an ultrasensitive capacitive flexible pressure sensor based on the ionic migration confinement effect, which comprises an upper electrode layer and a lower electrode layer, and a dielectric layer is arranged between the upper electrode layer and the lower electrode layer. The dielectric layer comprises an ion migration regulation and control layer and ion limiting composite layers arranged on the upper side and the lower side of the ion migration regulation and control layer; each ion confinement composite layer comprises an ion confinement composite film fixed on the electrode layer on the corresponding side, and a plurality of first micro bulges are arranged on the surface of one side, facing the ion migration regulation and control layer, of the ion confinement composite film; the ion migration regulation and control layer is a nano-channel fiber membrane containing an ion channel; a plurality of second micro bulges are arranged on the surfaces of the upper side and the lower side of the nano-channel fiber membrane; and the plurality of first micro bulges and the plurality of second micro bulges on the corresponding sides are mutually embedded to form an interlocking structure in a horizontal plane. The sensor provided by the invention has high sensitivity in a wide pressure range.

Small molecule inhibitors of Nav1.8 voltage-gated sodium ion channel, including compounds of formula (I), (II), (III), (IV), and (V) are described. Also described are pharmaceutical compositions containing a compound of formula (I), (II), (III), (IV), and (V) and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, such as pain and pain-associated diseases and cardiovascular diseases, such as atrial fibrillation.

The invention relates to the technical field of biology, and particularly discloses a supercooled cell preserving fluid as well as a preserving method and application thereof. The preserving fluid is mainly prepared from RPX basic cell preserving fluid, an energy substrate, a calcium ion channel blocker, a Na < + > / H < + > exchange channel inhibitor, a colloid impermeable cell protective agent, a cell apoptosis inhibitor, an antioxidant, an inflammation inhibitor, a colloid osmotic pressure regulator, a PH regulator and the like according to a certain proportion. According to the preservation method, the cells are preserved under the subcooling condition of-1 DEG C to-7 DEG C, the cell metabolism rate is reduced to the maximum extent, meanwhile, structural and functional damage caused by freezing to the cells is eliminated, and the effect that the survival rate of the recovered cells exceeds 80% after the cells are preserved for more than 18 months under the non-freezing condition is achieved; the application opens up a way for long-term non-freezing preservation of special functional cells of cells and genetic engineering and clinical cell treatment products, provides an effective method, and lays a foundation for starting a new stage of non-freezing long-term preservation of the cells.

The invention discloses a microphase separation hydrogel electrolyte with ion selectivity and a preparation method and application thereof. The electrolyte is prepared by constructing a microphase separation polymer network composed of a polyanionic polymer and an ion exchange group-containing polymer in a synergistic manner and inducing crosslinking by using metal ions. The formation of a continuous ion transmission channel in the hydrogel is realized. The technical problem that high ionic conductivity and high ionic transference number are difficult to obtain at the same time in a traditional hydrogel electrolyte is solved, spatial unwrapping and selective coordination of a polymer chain segment are induced through a microphase separation structure, and directional construction of an ion channel is achieved; and the ion conductivity of the electrolyte is remarkably improved, and meanwhile, the target ion transference number is further improved. The prepared hydrogel electrolyte has high mechanical stability, high ion flux and excellent ion selectivity, and can be widely applied to high-performance electrochemical devices such as batteries.

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R1, R2, R3, R12, and L are as defined herein. The compounds are antagonists of the resistant (R-type) voltage-gated calcium ion channel Cav 2.3. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in the treatment of diseases modulated Cav 2.3, including epilepsy, neurodegenerative conditions such as Parkinson's disease, focal, drug-resistant forms of epilepsy, and other neurological disorders such as developmental and epileptic encephalopathies and Phelan-McDermid and Fragile X syndromes.

The utility model relates to the technical field of combs, in particular to an anti-frizzy comb with a built-in ion generator, which comprises a mounting shell, a handle fixedly mounted at one end of the mounting shell, the handle is communicated with the mounting shell, the ion generator is arranged in the handle, a power supply is mounted in the handle, and a mounting plate is arranged in the mounting shell. The mounting shell is divided into an ion channel and a mounting cavity through a mounting plate, comb teeth are clamped on the mounting shell, circular holes distributed in an array are formed in the comb teeth, an adjustable fixing assembly used for fixing the comb teeth is arranged in the mounting shell, and tens of millions of negative ions can be released when hair is combed through the ion generator and the circular holes; the negative ions are arranged on the comb teeth, so that the negative ions make contact with the hair, the cuticle of the hair is flattened, the hair is helped to keep moisture, the frizz and flying of the hair can be eliminated, the comb teeth are conveniently clamped and fixed through the adjustable fixing assembly and the arc-shaped baffle, and meanwhile the comb teeth can be replaced when damaged.

The invention relates to the technical field of biomedical materials, in particular to a thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment, and a preparation method comprises the following steps: adding silver selenide nanoparticles into a 10% methacryloyl gelatin solution, putting the precursor solution into a mold, adding 0.25% phenyl (2, 4, 6-trimethyl-1, 3-pentanedione), and stirring for 20-30 minutes to obtain the thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment. 2, 6-trimethylbenzoyl) lithium phosphate (LAP) photoinitiator is added, ultraviolet light curing forming is carried out, and after demolding, soaking is carried out to remove residual monomers and the initiator; wherein the drug-containing group is prepared by replacing water with an artemisinin solution, and Ag2Se-coated GelMA or Ag2Se-coated GelMA / ART composite hydrogel is obtained. The electric field generated by the thermoelectric effect in the invention activates a voltage-gated calcium ion channel, inhibits PHD2, and up-regulates an HIF-1 / VEGF-A signal axis, thereby promoting angiogenesis. Meanwhile, the artemisinin also plays an anti-inflammatory role.

Manufacturing structure for a positive electrode plate provided with a positive electrode suspension by electrostatic adhesion, wherein the positive electrode plate comprises a positive electrode substrate and a layer of positive electrode suspension adhering thereto; the positive electrode suspension consists of a material that remains solid at room temperature; the positive electrode suspension is produced independently without needing to be mixed with the positive electrode substrate during the manufacturing process; the positive electrode substrate and the positive electrode suspension can be produced separately; the positive electrode suspension is solvent-free, solid, and has a long shelf life; and the manufacturing structure of the positive electrode plate provided with the positive electrode suspension by electrostatic adhesion comprises: a raw material tank for receiving the positive electrode suspension material; and The positive electrode mass material comprises the following: a multitude of positive electrode particles that can store or release lithium ions; the positive electrode particles constitute an active material; and A variety of PEOs (polyethylene oxides) serve to guide lithium ions and increase the conductivity of the positive electrode for lithium ions; the PEOs are thermoplastic, therefore they melt at high temperatures and are in a molten state; and a variety of PVDFs (polyvinylidene fluoride) or PVDF-HFPs (vinylidene fluoride-co-hexafluoropropylene); the PVDFs or PVDF-HFPs and the PEOs are polymer materials; when the positive electrode suspension is heated to a specific temperature, a copolymer of the PEOs and the PVDFs or PVDF-HFPs melts in the positive electrode suspension, causing the positive electrode suspension to become sticky; the sticky positive electrode suspension adheres to the positive electrode substrate, thus forming the positive electrode plate; and a variety of conductivity agents to increase the electrical conductivity of the positive electrode suspension; and a variety of lithium salts for the lubrication of the polymer chains of the polymer material and for increasing the ionic conductivity; and a variety of ceramic particles for guiding the lithium ions and forming lithium ion channels to prevent side reactions between the lithium ions and the positive electrode suspension due to abnormal deposition of lithium ions in the positive electrode suspension; and a variety of positive electrode particles, ceramic particles, conductivity agents and lithium salts, which are dispersed in the polymer material and support the positive electrode suspension; and The positive electrode material remains a solid at room temperature; when the positive electrode material is heated to a specific temperature between 50°C and 240°C, the PEOs in the positive electrode material melt, so that the positive electrode material adheres to the positive electrode substrate and forms the positive electrode plate; and An electrostatic spray gun is connected to the raw material container and serves to hold the positive electrode suspension. It applies a voltage to the suspension, generating electrostatic charges on its surface and forming charged fine particles. These charged fine particles are sprayed from the spray gun's outlet. At the outlet of the spray gun, a roller conveyor mechanism advances a carrier plate. This carrier plate collects the charged fine particles sprayed from the outlet and distributes them onto the substrate of the positive electrode to form a first electrode plate. The carrier plate consists of a metal sheet; and Since each particle of the positive electrode material is extremely small, the particles electrostatically adsorb to one another when the positive electrode material is sprayed onto the substrate using an electrostatic spray gun, thus forming a high layer density. This creates the positive electrode plate with high energy density, and the lithium-ion conductivity is further increased. Upon contact of the charged fine particles with the metal sheet, an electrostatic attraction arises between the charged fine particles and the metal sheet, causing the charged fine particles to adhere to the metal sheet and form the first electrode plate. a heating element connected to the roller belt mechanism, serving to heat the first electrode plate so that the charged fine particles are converted into a molten material and adhere to the positive electrode substrate to form the positive electrode plate; and Since the positive electrode plate with the positive electrode mass layer formed from the positive electrode mass material does not require baking and rolling steps, the materials inside the positive electrode mass material are not damaged by thermal or mechanical stresses.

The invention belongs to the technical field of battery manufacturing, and provides a positive pole piece of a lithium-manganese dioxide battery and a manufacturing process and application of the positive pole piece. A polymer ion channel coating is arranged on the surface of a positive active layer of the positive pole piece; and the polymer ion channel coating contains a polymer ion channel with a porous structure. By forming the ion channel layer with the porous structure on the surface of the positive electrode, the wettability of the surface of the positive electrode plate to electrolyte can be improved while the stability of the positive electrode is maintained. Moreover, the reaction activity of a polymer ion channel is low, the polymer ion channel cannot react with a positive electrode active substance in the positive electrode or an electrolyte and the like generally, the stability is good, the problem that electrolyte on the surface of the positive electrode volatilizes quickly under the long-term high-temperature condition of a primary battery can be better solved through coating and film forming, and the electrolyte wettability of the surface of the positive electrode is more effectively improved.

A device for activating the mitochondrion, wherein negative charge and reactive oxygen are delivered from outside to the mitochondrion via a negative charge and reactive oxygen delivery unit to serve as material for the mitochondrial redox reaction; and, wherein a calcium ion channel stimulation unit can stimulate an in vivo calcium ion to transport a protein across a calcium ion on an inner membrane of the mitochondrion into a matrix space of the mitochondrion, whereby an influx of the calcium ion promotes the depolarization of the mitochondrion and increases the activity of mitochondrial oxidative phosphorylation.

The application discloses application of hen egg white lysozyme (HEL) in relieving chronic pain, and experiment results show that HEL significantly and selectively relieves inflammatory pain, neuropathic pain and static mechanical allodynia induced by chemotherapy pain. Meanwhile, experiments show that HEL causes the expression of a mechanical sensitivity ion channel TACAN in the PRKN / TACAN pathway on the cell membrane to be reduced by up-regulating the expression of PRKN protein of primary sensory neurons in the dorsal root ganglion, thereby significantly inhibiting static mechanical allodynia. The application firstly finds that HEL has the effect of relieving static mechanical allodynia and a deep mechanism, and the source of HEL is non-toxic and safe, and has potential application value in preparation of medicines for preventing, treating and relieving chronic pain, and has great clinical significance.

The invention discloses an ion channel protein near-atomic scale confinement dissolution electrochemical machining method based on a bionic confinement interface. The method is characterized in that a bionic phospholipid bilayer mask is spread on a workpiece anode to shield a non-processing area, ion channel protein is embedded into the bionic phospholipid bilayer mask to serve as an electrolyte channel, and when the bionic phospholipid bilayer mask is powered on, the anode dissolution reaction is strictly limited in the ion channel protein channel. Millivolt-level picosecond-nanosecond pulse voltage or current is adopted on the time scale so that anode metal atoms can be removed one by one, electrolytic products are discharged in the modes of electrolyte adjustment, microcosmic acting force, micro vibration and the like so as to ensure sustainable generation of electrochemical reaction, and therefore near-atomic-scale electrolytic machining is achieved. The electrochemical machining technology and the biological field are fused in an interdisciplinary mode, the near-atomic-scale electrochemical dissolution reaction space is constructed, the capacity of electrochemical machining for removing materials in an ion form is approached, and near-atomic-scale electrochemical machining is achieved.

The invention provides acellular matrix hydrogel loaded with animal acellular omentum particles as well as a preparation method and application of the acellular matrix hydrogel loaded with the animal acellular omentum particles, and relates to the technical field of tissue engineering and regenerative medicine. Comprising a decellularization treatment agent, a decellularization matrix, functional particles, an enzymolysis agent, a cross-linking stabilizer, a functional additive and a solvent, the functional additive is prepared from PDA coated Fe3O4 magnetic nano particles, phosphorylated polyglycerol sebacate and liposome coated silver nano particles. The PDA-Fe3O4 magnetic nanoparticles of the functional additive generate mechanical signals under the action of an external magnetic field, a Piezo1 mechanical gating cation channel is activated to promote calcium ion internal flow, and the autonomous mineralization ability of phosphorylated polyglycerol sebacate is combined, so that the activity of the bone differentiation marker alkaline phosphatase is effectively improved, and the bone differentiation marker alkaline phosphatase is prepared. The combination of the PDA coated Fe3O4 magnetic nanoparticles and the phosphorylated polyglycerol sebacate integrates a magnetic response mineralization system.

The invention discloses an electrodialysis device for extracting lithium from salt lake brine, the electrodialysis device comprises a cation exchange membrane, an electrodialysis partition plate and an anion exchange membrane, the electrodialysis partition plate comprises a fixed frame and a block net, and the block net comprises a plurality of wavy hollow pipelines which are arranged in a cavity hole and are arranged at intervals in a criss-cross manner; a through hole is formed in the side wall of the hollow pipeline and is used for enabling brine to act on the cation exchange membrane and the anion exchange membrane through the hollow pipeline; according to the invention, the wave-shaped structure in the grid net formed by the wave-shaped hollow pipeline can prevent a two-dimensional channel from being completely vertical to the direction of an electric field in the electrodialysis operation process, so that the acting force of the electric field in the channel direction is improved; and the guide pipe is used for guiding brine to enter the hollow pipeline block net to act on each area of the membrane surface, so that the utilization rate of a two-dimensional channel film ion channel is improved, the concentration polarization phenomenon of electrodialysis membrane surface ions is weakened, the lithium extraction efficiency is effectively improved, the electrodialysis energy consumption is reduced, and the application advantage is remarkable.

The present invention utilizes thin film deposition technology to directly deposit a compound of electrode affinity, hydrogen, and carbon atoms and its derivatives or composites onto the surface of an electrode foil, positive electrode plate or negative electrode plate to form an electrospun membrane which can directly serve as a separator membrane in an electrochemical device. Due to the strong affinity of the deposited thin film membrane to the surface of the electrode foil, positive electrode plate or negative electrode plate via thin film deposition process's attraction, a binding interface thereof exhibits an ordered ion channel layer which can serve as a beneficial artificial electrolyte interface layer on the current collector or electrodes.