418 results about "Ionic Channels" patented technology

The invention provides an electrode assembly manufacturing device and method, the electrode assembly manufacturing device comprises a winding needle and a heating part, the winding needle is used for winding a pole piece and a separator and forming a winding structure, and the heating part is used for being inserted into the winding center of the winding structure and heating the winding structure. According to the manufacturing equipment, the heating component can heat the winding structure at the winding center of the winding structure, so that at least part of ion channels in the separator of the inner ring in the winding structure are fused and closed, shuttling of ions is blocked, lithium precipitation of the winding structure can be reduced, and the risk of lithium precipitation of the battery can be effectively reduced.

The invention belongs to the technical field of lithium ion battery positive electrode materials, and particularly relates to a double-strategy modified high-nickel positive electrode material as well as a preparation method and application thereof. According to the double-strategy modified high-nickel positive electrode material, a high-nickel positive electrode material serves as a matrix, surface coating and bulk phase doping are achieved at the same time through competitive doping of main group elements, a coating layer is a fast ion conductor LiLaO2 nano layer, and a bulk phase doping element is Y. The fast ion conductor coating layer can provide an additional ion channel, promote conduction of ions on the surface of the positive electrode material, reduce interface impedance and improve the rate capability of the battery. The doping elements can optimize the crystal structure of the positive electrode material and can relieve stress generated in the charging and discharging process, so that phase change and structural degradation are reduced, and the structural stability of the positive electrode material is improved.

The invention provides a modified doped lithium phosphorus sulfur chlorine solid electrolyte as well as a preparation method and application thereof, and belongs to the technical field of solid electrolytes. The Al and Cl double-doping mode can improve the mixing proportion of ions in lattices of Li6PS5Cl and expand ion channels, so that the ionic conductivity of the Li6PS5Cl system electrolyte and the stability to lithium are improved, and the ionic conductivity of the prepared modified doped lithium phosphorus sulfur chlorine solid electrolyte is larger than 3 mS / cm. The modified lithium-phosphorus-sulfur-chlorine-doped solid electrolyte provided by the invention is grey white powder in appearance, is uniform and free of foreign matters, and shows an argyrodite type, and the space group of a crystal structure is F43m. The preparation method of the modified doped lithium-phosphorus-sulfur-chlorine solid electrolyte is simple, the precursor can be obtained only by performing ball milling for 8 hours, rare and scattered noble metals are not used, and the production cost is reduced.

The invention relates to the field of medicines. Specifically, the invention relates to a voltage-gated calcium channel alpha2delta subunit ligand containing a polycyclic gamma-aminobutyric acid structure as shown in a general formula I, a preparation method of the voltage-gated calcium channel alpha2delta subunit ligand and application of the voltage-gated calcium channel alpha2delta subunit ligand to treatment of chronic neuropathic pain, epilepsy and anxiety. # imgabs0 #

The invention relates to a composite diaphragm with high ionic conductivity, a composite solid electrolyte and a preparation method thereof. The composite diaphragm is composed of a lithium lanthanum-based fluorine-doped solid electrolyte LLMOF and a base membrane, the chemical general formula of the LLMOF is Li < x > La < y > M < 1 > < z > M < 2 > < w > M < 3 > O < 6 > F, wherein M1 is a tetravalent cation, M2 is a pentavalent cation, and M3 is a hexavalent cation; 1 < x + 3y < 5, 0 < x < = 2, and 1 / 3 < y < 5 / 3; 0 < = z < = 2, 0 < = w < = 2, 0 < = u < = 2, z + w + u = 2; the base membrane is a large-aperture base membrane, and the aperture r is more than or equal to 200nm and less than or equal to 1mu m; the particle size D50 of the LLMOF is 50 nm to 1 [mu] m, and the particle size D50 of the LLMOF is less than or equal to the aperture r of the base film. According to the composite diaphragm disclosed by the invention, the LLMOF solid electrolyte with an ion channel function is introduced, so that efficient conduction of ions is realized; the particle size is matched with that of a large-aperture base membrane, the membrane can be uniformly embedded into membrane holes, a continuous conduction path is constructed, and the ionic conductivity is improved; meanwhile, the composite diaphragm has excellent thermal stability and interface wettability, interface impedance is effectively reduced, and growth of lithium dendrites is inhibited.

The invention relates to application of an MYZAP overexpression vector in preparation of a medicine for preventing and treating MIRI, and belongs to the technical field of biological medicine. In order to solve the problem that application of gene drugs in prevention and treatment of myocardial ischemia reperfusion injury is limited, the invention provides application of an MYZAP gene overexpression recombinant vector in preparation of drugs for prevention and treatment of myocardial ischemia reperfusion injury, and the MYZAP gene overexpression recombinant vector is an adeno-associated virus vector AAV9-MYZAP for overexpressing MYZAP. Experiments prove that MYZAP overexpression can improve the cardiac function after myocardial ischemia reperfusion, reduce the occurrence rate of arrhythmia and improve the functions of sodium ion channels, potassium ion channels and calcium ion channels of myocardial cells. On the basis, the invention further provides a medicine for preventing and treating myocardial ischemia reperfusion injury, a new strategy is provided for gene therapy of myocardial ischemia reperfusion injury, and the medicine has a wide clinical application prospect.

The invention belongs to the technical field of lithium adsorbents, and particularly relates to lithium ion sieve hydrogel with double properties and a preparation method and application thereof. According to the prepared lithium ion sieve hydrogel, ions (Al, Fe and the like) with the same valence state and different sizes are used for replacing part of manganese ions, so that the crystal structure of an ion sieve is more stable, an ion channel is wider, and therefore, the lithium ion sieve hydrogel has relatively high lithium ion adsorption capacity and stability; the high adsorption capacity and mechanical strength can still be kept in multiple cyclic adsorption-desorption cycles, the lithium ion adsorption capacity cannot be lost due to dissolution loss of the lithium ion sieve, and the lithium ion sieve has an integral structure while having a large surface area by means of device formation of the hydrogel. Therefore, the method has excellent recovery capability and long service life, can keep the morphology of the device from being damaged in a complex use environment, is convenient to use and recover, and has important theoretical significance and application value.

The invention discloses a preparation method of a cement-based structured electrolyte with high ion conductivity and the electrolyte, and the preparation method comprises the following steps: mixing a polymer solution, cement and fine sand to obtain a polymer-cement paste; and performing low-temperature closed maintenance on the polymer-cement paste, and standing at room temperature to obtain the cement-based structured electrolyte. The controlled phase separation technology is adopted, elastic phase separation of a polymer network is carried out earlier than cement hydration, cement becomes a framework of the polymer network in a self-adaptive mode in the hydration process, the interface of the polymer network and the cement is good, and a continuous high-conduction ion channel can be formed; and the preparation process is simple to operate and high in repeatability.

The present invention discloses a method for preparing a high-ionic conductivity cement-based structured electrolyte and the electrolyte, comprising: mixing a polymer solution, cement, and fine sand to obtain a polymer-cement slurry; subjecting the polymer-cement slurry to low-temperature, sealed curing, and then allowing it to stand at room temperature to obtain a cement-based structured electrolyte. The present invention utilizes a controlled phase separation technique to enable elastic phase separation of the polymer network prior to cement hydration. During the hydration process, the cement adaptively forms the backbone of the polymer network, resulting in a good interface between the two, capable of forming continuous, high-conductivity ion channels. The preparation process is simple to operate and highly reproducible.

The invention relates to the technical field of waste landfill treatment, and discloses a sludge and fly ash mixed filling treatment process which comprises the steps of porous medium composite adsorption medium preparation, ion exchange pre-activation modification, osmotic pressure gradient layer construction, electrochemical activation field formation, ion channel dredging treatment, osmotic pressure self-repairing adjustment, electrochemical self-cleaning maintenance and the like. According to the method, efficient removal and long-term stable treatment of heavy metal pollutants are achieved through the synergistic effect of porous medium enhanced permeation adsorption and ion exchange pre-activation in combination with osmotic pressure gradient directional migration and electrochemical activation, the heavy metal removal rate is high, the landfill system stably operates for a long time, manpower is reduced, and the environmental pollution risk is effectively reduced.

The invention provides a polypeptide and application thereof in preparation of a TRPV1 inhibitor, and particularly belongs to the technical field of biomedicine. The invention provides a polypeptide which is named as Cath2, and the amino acid sequence of the polypeptide is as shown in SEQ ID NO. 1. The Cath2 can significantly inhibit activation of a TRPV1 ion channel of a mammal, inhibits TRPV1 receptors of other species including human beings in a targeted manner, and can be applied to research of TRPV1-related ion channel diseases and development of drugs. Specifically, the composition can enhance the resistance of mammals to pruritus and pain, can be used as a resource to be developed into an itching relieving product or an analgesic product and the like, and is applied to human beings and other animals to relieve pruritus and pain.

The invention relates to an anti-fatigue refreshing functional chewing gum containing natural active ingredients, which relates to the technical field of food, and comprises a gum base, a natural sweetening agent and an active ingredient mixture, the mustard extract and coffee are innovatively combined to form a dual-channel nerve activation mechanism, the mustard extract realizes instant refreshing through a targeted oral trigeminal nerve TRPA1 ion channel, caffeine maintains continuous excitation through antagonism of a central adenosine receptor, and the space-time cooperation of the mustard extract and the coffee breaks through the limitation of a single path. Meanwhile, a rhodiola rosea extract, a sea-buckthorn extract, an American ginseng extract and astragalus polysaccharide are compounded, so that a triple anti-fatigue physiological barrier with functions of nerve regulation, oxidative stress inhibition and energy metabolism optimization is formed. In the preparation process, a microcapsule embedding technology is adopted to control slow release of mustard active ingredients, menthol flavor is combined to synergistically trigger TRP channel dual activation, and unification of efficacy and palatability is achieved.

The invention discloses a high-flux high-pollution-resistance nanofiltration membrane as well as a preparation method and application thereof. The scheme is realized by constructing a gradient separation layer compounded by modified MOF and polyamide on a porous support layer; the preparation method comprises the following steps: preparing a water phase from modified MOF grafted with carboxylate radical and sulfonate ion recognition groups on the surface, a polyamine monomer and an ion channel regulator, carrying out interfacial polymerization on the water phase and an oil phase containing a fluorine-containing acyl chloride monomer on the surface of a porous support membrane, and carrying out heat treatment and metal ion post-treatment, the modified MOF in gradient distribution in the nanofiltration membrane can specifically adsorb Ca < 2 + >, Mg < 2 + > and other scaling ions, and scale formation is inhibited from the source; the composite structure simultaneously realizes high flux and high selectivity; the retention rate of the membrane to Na2SO4 under 0.6 MPa is greater than or equal to 99.2%, the retention rate of the membrane to NaCl is less than or equal to 15%, the flux of pure water is greater than or equal to 20 L.m <-2 >. H <-1 >. Bar <-1 >, and the flux attenuation rate is less than or equal to 16.7% after the membrane runs in high-hardness, high-COD and high-salinity wastewater for 120 hours; the scheme is particularly suitable for zero-discharge pretreatment of high-salinity wastewater such as solid waste percolate with the TDS of 5-30% and chemical engineering.

Disclosed in the present application are a compound as represented by formula (I), a pharmaceutically acceptable salt, a stereoisomer, a tautomer, or an N-oxide, and the use thereof in the preparation of a drug for treating, preventing or alleviating voltage-gated sodium ion channel-related diseases.

The application provides a mixed matrix membrane for efficient ion separation and a preparation method thereof, and belongs to the technical field of separation membranes.The application mixes an aluminum salt and sodium hydroxide in an organic solvent, then adds a heterocyclic organic ligand containing nitrogen to obtain a MOF precursor solution; adds polyimide into the MOF precursor solution to obtain a casting solution; pours the casting solution into a mold and performs vacuum heating, then performs peeling, soaks in ethanol, and then performs drying to obtain the mixed matrix membrane for efficient ion separation.The application realizes uniform dispersion of MOF-303 in the whole matrix by controlling the MOF loading, and constructs continuous ion channels by the uniformly dispersed MOF-303 crystal structure, so that the selectivity of the membrane to monovalent ions is further improved.The operation is simple, and the cost is low.

The present invention relates to a novel class of bicyclic derivatives that function as small-molecule KCQN2 / 3 (Kv7.2 / 3) potassium channel activators, along with their pharmaceutical composition, method of preparation, and therapeutic applications. These compounds, represented by Formula (I), and defined by specific substituents and structural characteristics as described in the specification. By modulating or enhancing the activation of Kv7.2 / 3 potassium channels, these derivatives hold therapeutic potential for treating seizure disorders and other conditions influenced by potassium ion channel modulation.

Specifically, firstly, montmorillonite (MMT) powder is stripped into a nanosheet layer by using an ultrasonic dispersion technology, a two-dimensional layered structure of the nanosheet layer forms rich nanoscale ion channels, and an efficient path is provided for ion directional migration in salinity gradient power generation; meanwhile, after the cellulose is stripped and dispersed by a DMSO solution, a uniform polymer network is formed, the uniform polymer network is used as a substrate material to improve the mechanical strength of the film, and the interfacial ion adsorption and conduction capability is optimized through hydrophilic groups. When the MMT nanosheet and the cellulose suspension are mixed, the MMT nanosheet and the cellulose suspension form an interpenetrating network structure through physical winding and electrostatic interaction, ordered stacking is achieved through vacuum filtration, and finally the composite film with both ion selectivity and structural stability is formed on the substrate. The preparation process is high in material adaptability, green and controllable in preparation process, high in competitiveness in large-scale production and practical application and beneficial to popularization.

The present invention relates to a polysubstituted aryl derivative, a preparation method therefor, and the use of a pharmaceutical composition containing the derivative in medicine. Specifically, the present invention relates to a polysubstituted aryl derivative as shown in general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, in particular as a Kv1.3 potassium ion channel inhibitor, wherein the definition of each substituent in general formula (I) is the same as defined in the description.

The invention discloses a KCR1 mutant suitable for plant potassium ion steady state regulation and application thereof, and relates to the technical field of bioengineering, and the KCR1 mutant at least has T136A and G140A mutations on the basis of light-operated potassium ion channel protein KCR1. The invention also discloses a gene for coding the KCR1 mutant. The invention also discloses application of the KCR1 mutant or gene in plant culture, cultivation of new plant varieties or preparation of plant culture products. The KCR1 mutant disclosed by the invention has a blue-shift excitation spectrum compared with a wild type, can realize accurate regulation and control of plant potassium ion flow through illumination regulation and control, and has a relatively great application value in the aspects of light-controlled plant cultivation, plant potassium ion channel research and the like.

The invention provides a milk protein peptide which takes milk protein as a raw material and has the effects of promoting calcium absorption and improving bone health and application of the milk protein peptide. Specifically, milk protein peptide sequences, including YGGVSL and SQRY, are screened by adopting enzymolysis, sequence identification and molecular docking methods. The milk protein peptide is proved to have high calcium transport promoting capacity in the in-vitro intervention of Caco-2 cells, and the milk protein peptide is proved to have the capacity of promoting osteogenesis and inhibiting bone resorption in the in-vitro intervention of MC3T3-E1 mouse embryo osteoblasts. In animal experiments, by increasing the content of blood calcium and bone calcium, reducing the content of excrement calcium, improving mRNA expression of calcium ion channel protein, calcium binding protein and peptide transporter in intestinal tracts, enhancing the efficiency of calcium entering blood, promoting osteogenesis and inhibiting bone resorption, the milk protein peptide is comprehensively proved to have the capabilities of improving calcium resorption of organisms and improving bone health. The milk protein peptide has both functionality and nutrition, and has a wide application prospect in the aspect of bone health.

The invention discloses a bionic nanofluidic ion-based patterned flexible sensing device and a preparation method thereof, the flexible sensing device comprises a patterned carbon nanotube-based nanofluidic ion channel flexible high-molecular polymer film, an electrolyte solution is arranged in a nanofluidic ion channel, the nanofluidic ion channel is modified by functional molecules, and the nanofluidic ion channel is a flexible high-molecular polymer film. The inner diameter of the bionic nanofluidic ion channel ranges from 1 nm to 100 nm, and the nanofluidic ion-based flexible sensing device has mechanical responsiveness, humidity responsiveness and the like.

A method for recovering NH4+ or K+ ions from manure wastewater is disclosed. The method includes contacting manure wastewater having organic matter and salts with an ion-selective redox material with ionic channels. The manure wastewater reduces the ion-selective redox material which spontaneously takes up NH4+ or K+ ions from the manure wastewater. NH4+-or K+ may be released electrochemically and paired with the simultaneous electrosynthesis of value-added chemicals.

The invention provides a pharmaceutical composition and application thereof in preparation of a compound preparation, and belongs to the field of medicines. The pharmaceutical composition comprises a potassium ion channel opener, a 5 alpha-reductase inhibitor and a phosphodiesterase 5 inhibitor. The pharmaceutical composition can synergistically promote treatment of androgen dependent diseases or prevention of complications, and by taking the pharmaceutical composition of minoxidil, finasteride and tadalafil as an example, the effects in a benign prostatic hyperplasia rat model and an androgenic alopecia mouse model are verified, which indicates that the minoxidil, finasteride and tadalafil have a synergistic interaction effect, and the pharmaceutical composition can be used for treating the androgen dependent diseases or preventing the complications. Good clinical application prospects are realized.

The invention relates to the field of sensors for realizing an ionic migration confinement effect by using silicon dioxide, and discloses an ultrasensitive capacitive flexible pressure sensor based on the ionic migration confinement effect, which comprises an upper electrode layer and a lower electrode layer, and a dielectric layer is arranged between the upper electrode layer and the lower electrode layer. The dielectric layer comprises an ion migration regulation and control layer and ion limiting composite layers arranged on the upper side and the lower side of the ion migration regulation and control layer; each ion confinement composite layer comprises an ion confinement composite film fixed on the electrode layer on the corresponding side, and a plurality of first micro bulges are arranged on the surface of one side, facing the ion migration regulation and control layer, of the ion confinement composite film; the ion migration regulation and control layer is a nano-channel fiber membrane containing an ion channel; a plurality of second micro bulges are arranged on the surfaces of the upper side and the lower side of the nano-channel fiber membrane; and the plurality of first micro bulges and the plurality of second micro bulges on the corresponding sides are mutually embedded to form an interlocking structure in a horizontal plane. The sensor provided by the invention has high sensitivity in a wide pressure range.

Small molecule inhibitors of Nav1.8 voltage-gated sodium ion channel, including compounds of formula (I), (II), (III), (IV), and (V) are described. Also described are pharmaceutical compositions containing a compound of formula (I), (II), (III), (IV), and (V) and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, such as pain and pain-associated diseases and cardiovascular diseases, such as atrial fibrillation.

The invention relates to the technical field of biology, and particularly discloses a supercooled cell preserving fluid as well as a preserving method and application thereof. The preserving fluid is mainly prepared from RPX basic cell preserving fluid, an energy substrate, a calcium ion channel blocker, a Na < + > / H < + > exchange channel inhibitor, a colloid impermeable cell protective agent, a cell apoptosis inhibitor, an antioxidant, an inflammation inhibitor, a colloid osmotic pressure regulator, a PH regulator and the like according to a certain proportion. According to the preservation method, the cells are preserved under the subcooling condition of-1 DEG C to-7 DEG C, the cell metabolism rate is reduced to the maximum extent, meanwhile, structural and functional damage caused by freezing to the cells is eliminated, and the effect that the survival rate of the recovered cells exceeds 80% after the cells are preserved for more than 18 months under the non-freezing condition is achieved; the application opens up a way for long-term non-freezing preservation of special functional cells of cells and genetic engineering and clinical cell treatment products, provides an effective method, and lays a foundation for starting a new stage of non-freezing long-term preservation of the cells.

The invention discloses a microphase separation hydrogel electrolyte with ion selectivity and a preparation method and application thereof. The electrolyte is prepared by constructing a microphase separation polymer network composed of a polyanionic polymer and an ion exchange group-containing polymer in a synergistic manner and inducing crosslinking by using metal ions. The formation of a continuous ion transmission channel in the hydrogel is realized. The technical problem that high ionic conductivity and high ionic transference number are difficult to obtain at the same time in a traditional hydrogel electrolyte is solved, spatial unwrapping and selective coordination of a polymer chain segment are induced through a microphase separation structure, and directional construction of an ion channel is achieved; and the ion conductivity of the electrolyte is remarkably improved, and meanwhile, the target ion transference number is further improved. The prepared hydrogel electrolyte has high mechanical stability, high ion flux and excellent ion selectivity, and can be widely applied to high-performance electrochemical devices such as batteries.

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R1, R2, R3, R12, and L are as defined herein. The compounds are antagonists of the resistant (R-type) voltage-gated calcium ion channel Cav 2.3. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in the treatment of diseases modulated Cav 2.3, including epilepsy, neurodegenerative conditions such as Parkinson's disease, focal, drug-resistant forms of epilepsy, and other neurological disorders such as developmental and epileptic encephalopathies and Phelan-McDermid and Fragile X syndromes.

The utility model relates to the technical field of combs, in particular to an anti-frizzy comb with a built-in ion generator, which comprises a mounting shell, a handle fixedly mounted at one end of the mounting shell, the handle is communicated with the mounting shell, the ion generator is arranged in the handle, a power supply is mounted in the handle, and a mounting plate is arranged in the mounting shell. The mounting shell is divided into an ion channel and a mounting cavity through a mounting plate, comb teeth are clamped on the mounting shell, circular holes distributed in an array are formed in the comb teeth, an adjustable fixing assembly used for fixing the comb teeth is arranged in the mounting shell, and tens of millions of negative ions can be released when hair is combed through the ion generator and the circular holes; the negative ions are arranged on the comb teeth, so that the negative ions make contact with the hair, the cuticle of the hair is flattened, the hair is helped to keep moisture, the frizz and flying of the hair can be eliminated, the comb teeth are conveniently clamped and fixed through the adjustable fixing assembly and the arc-shaped baffle, and meanwhile the comb teeth can be replaced when damaged.

The invention relates to the technical field of biomedical materials, in particular to a thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment, and a preparation method comprises the following steps: adding silver selenide nanoparticles into a 10% methacryloyl gelatin solution, putting the precursor solution into a mold, adding 0.25% phenyl (2, 4, 6-trimethyl-1, 3-pentanedione), and stirring for 20-30 minutes to obtain the thermoelectric bionic skin for promoting healing of diabetic wounds by restoring a biological electric field microenvironment. 2, 6-trimethylbenzoyl) lithium phosphate (LAP) photoinitiator is added, ultraviolet light curing forming is carried out, and after demolding, soaking is carried out to remove residual monomers and the initiator; wherein the drug-containing group is prepared by replacing water with an artemisinin solution, and Ag2Se-coated GelMA or Ag2Se-coated GelMA / ART composite hydrogel is obtained. The electric field generated by the thermoelectric effect in the invention activates a voltage-gated calcium ion channel, inhibits PHD2, and up-regulates an HIF-1 / VEGF-A signal axis, thereby promoting angiogenesis. Meanwhile, the artemisinin also plays an anti-inflammatory role.