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4509results about "Cell receptors/surface-antigens/surface-determinants" patented technology
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Monomethylvaline compounds capable of conjugation to ligands
ActiveUS20050238649A1Improve bioavailabilityImprove compoundAntibacterial agentsBiocideD-norephedrineBiochemistry
Owner:SEAGEN INC
Synthetic antibody phage libraries
InactiveUS20050079574A1High-quality target binding characteristicGenerate efficientlyAntibody mimetics/scaffoldsImmunoglobulins against cell receptors/antigens/surface-determinantsHeterologousIntravenous gammaglobulin
The invention provides immunoglobulin polypeptides comprising variant amino acids in CDRs of antibody variable domains. In one embodiment, the polypeptide is a variable domain of a monobody and has a variant CDRH3 region. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
Owner:GENENTECH INC
Neural regeneration peptides and methods for their use in treatment of brain damage
InactiveUS7563862B2High expressionEasy SurvivalPeptide/protein ingredientsGenetic material ingredientsNervous systemInjury brain
The invention discloses a family of peptides termed NRP compounds or NRPs that can promote neuronal migration, neurite outgrowth, neuronal proliferation, neural differentiation and / or neuronal survival, and provides compositions and methods for the use of NRPs in the treatment of brain injury and neurodegenerative disease. NRP compounds can induce neurons and neuroblasts to proliferate and migrate into areas of damage caused by acute brain injury or chronic neurodegenerative disease, such as exposure to toxins, stroke, trauma, nervous system infections, demyelinating diseases, dementias, and metabolic disorders. NRP compounds may be administered directly to a subject or to a subject's cells by a variety of means including orally, intraperitoneally, intravascularly, and directly into the nervous system of a patient. NRP compounds can be formulated into pharmaceutically acceptable dose forms for therapeutic use. Methods for detecting neural regeneration, neural proliferation, neural differentiation, neurite outgrowth and neural survival can be used to develop other neurally active agents.
Owner:CURONZ HLDG
Methods for selectively stimulating proliferation of T cells
InactiveUS7175843B2Increase the number ofBiocideCell receptors/surface-antigens/surface-determinantsAccessory moleculeExogenous growth
Owner:GENETICS INST LLC +2
Methods for selectively stimulating proliferation of T cells
InactiveUS7144575B2Increase the number ofBiocidePeptide/protein ingredientsAccessory moleculeExogenous growth
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR) / CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY +2
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor
Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Novel proteins with targeted binding
InactiveUS20050089932A1Stimulate and inhibit activityEasy screeningPeptide librariesPeptide/protein ingredientsMonomerComputational biology
Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and / or immuno-domains, selected monomer and / or immuno-domains, multimers and / or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
Owner:AMGEN MOUNTAIN VIEW
Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
InactiveUS6391452B1Taller in heightSlow down the mixing speedLiquid surface applicatorsPeptide/protein ingredientsNasal cavityNose
The present invention relates to pharmaceutical compositions for delivery of drugs intended to reside in the nose, compositions for nasal administration of drugs, e.g., antiviral agents, and particularly antiviral agents comprising the human major rhinovirus receptor, also known as intercellular adhesion molecule-1 (ICAM-1); to methods of making said nasal drug compositions, and to an improved process for the removal of residual solvent from pharmaceutical matrices.
Owner:BAYER PHARMA CORP
c-Met kinase binding proteins
InactiveUS20060008844A1Stimulate and inhibit activityCompound screeningPeptide librariesKinase bindingC-Met
Owner:AMGEN MOUNTAIN VIEW
Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
InactiveUS6113898AShrink tumorInhibit tumor growthPeptide/protein ingredientsAntipyreticDiseaseOrgan transplant rejection
The present invention relates to the identification of macaque antibodies to human B7.1 and B7.2 by screening of phage display libraries or monkey heterohybridomas obtained using B lymphocytes from B7.1 and / or B7.2 immunized monkeys. More specifically, the invention provides four monkey monoclonal antibodies 7B6, 16C10, 7C10 and 20C9 which inhibit the B7:CD28 pathway and thereby function as effective immunosuppressants. The invention further provides the complete DNA and amino acid sequences of the light and heavy chain of three primatized antibodies derived from those monkey monoclonal antibodies which bind B7.1 and possibly B7.2, primatized 7C10, primatized 7B6 and primatized 16C10. These primatized and monkey antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
Owner:BIOGEN INC
LDL receptor class A and EGF domain monomers and multimers
InactiveUS20050164301A1High affinityStimulate and inhibit activityPeptide librariesPeptide/protein ingredientsMonomerIntegrated systems
Specific monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
Owner:AMGEN MOUNTAIN VIEW
Characterization of individual polymer molecules based on monomer-interface interactions
InactiveUS7189503B2Bioreactor/fermenter combinationsMaterial nanotechnologySingle strandDouble strand
The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage of a single-stranded nucleic acid, but not of a double-stranded nucleic acid, from one pool to the other pool; (2) placing a nucleic acid polymer in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the single-stranded nucleic acid polymer passes through the channel so as to differentiate between nucleotide monomers that are hybridized to another nucleotide monomer before entering the channel and nucleotide monomers that are not hybridized to another nucleotide monomer before entering the channel.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
MHC Multimers in Cancer Vaccines and Immune Monitoring
InactiveUS20110318380A1Reduces infectious titerImprove efficacyPeptide/protein ingredientsImmunoglobulinsAntigenDisease
The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising cancer antigenic peptides and uses there of.
Owner:AGILENT TECH INC
Method for producing immunoglobulins containing protection proteins in plants and their use
The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
Owner:RGT UNIV OF CALIFORNIA +2
Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
InactiveUS6413777B1Reduce in quantityImprove the level ofPolypeptide with localisation/targeting motifCell receptors/surface-antigens/surface-determinantsMammalReactive site
A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a marker plasmid. The method is particularly suitable for the production of mammalian cell lines which secrete mammalian proteins at high levels, in particular immunoglobulins. Novel vectors and vector combinations for use in the subject cloning method are also provided.
Owner:BIOGEN INC
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.
Owner:ER SQUIBB & SONS INC
Immunosuppression modulating compounds
The present invention provides immunosuppression compounds capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signaling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides an application of the compositions containing the peptide moieties for preventive and / or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of peptide moieties as a testing or diagnostic agent or a research agent for such a disease.
Owner:AURIGENE DISCOVERY TECH
Enhanced erythropoiesis and iron metabolism
ActiveUS20050020487A1Increase productionReduce microcytosisBiocidePeptide/protein ingredientsDiseaseRed blood cell
The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Owner:FIBROGEN INC
Compositions and methods for priming monocytic dendritic cells and t cells for th-1response
InactiveUS20050059151A1Mammal material medical ingredientsBlood/immune system cellsDendritic cellMonocyte
The present invention provides compositions and methods for inducing maturation of immature dendritic cells (DC) and for priming those cells for inducing a type 1 immune response. The present invention also provides dendritic cell populations useful for activating and for preparing T cells polarized towards production of type 1 cytokines and / or a type 1 response. Similarly, activated, polarized T cell populations, and methods of making the same are provided.
Owner:NORTHWEST BIOTHERAPEUTICS INC
Epitopes
ActiveUS20070072797A1Block inhibitory effectPeptide/protein ingredientsSkeletal disorderEpitopeSclerostin
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
Owner:UCB SA +1
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
InactiveUS20050261229A1Stimulate productionEnhanceVirusesPeptide/protein ingredientsFc receptorAdjuvant
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.
Owner:MERCK PATENT GMBH
Phospholipid compositions and methods for their preparation and use
The present invention provides compositions that comprise a phospholipid component (that contains one or more phospholipids) and a pharmaceutically acceptable fluid carrier, where the phospholipid component is in the range from about 10% to about 90% of the total weight. Optionally, the compositions may further comprise non-phospholipid filler materials, where the amount of the non-phospholipid filler materials is in the range from about 5% to about 50% of the total weight. In certain embodiments, the compositions may be injectable, non-liposomal, and / or in form of a gel or a paste. The compositions of the present invention are useful for repairing and augmenting soft and / or hard tissues or for sustained local drug delivery.
Owner:ENCORE THERAPEUTICS
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
InactiveUS6962981B1VirusesCell receptors/surface-antigens/surface-determinantsImmunoenzymatic assayAntigen
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM′) of the PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM′ allows the use of an immunoenzymatic assay for their detection.
Owner:ER SQUIBB & SONS INC
Compositions and methods of altering cholesterol levels
ActiveUS20140275227A1Address poor treatment outcomesElevated cholesterolCell receptors/surface-antigens/surface-determinantsSugar derivativesCholesterolPolynucleotide
Owner:MODERNATX INC
PSCA antibodies and hybridomas producing them
InactiveUS20050026229A1Promote immune-mediated destructionHigh expressionOrganic active ingredientsTumor rejection antigen precursorsAntigenProstatic epithelium
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
Owner:RGT UNIV OF CALIFORNIA
Method of reducing injury to mammalian cells
InactiveUS20050059597A1Attenuated downstream NMDAR signalingReduced infarct volumeNervous disorderCell receptors/surface-antigens/surface-determinantsNR1 NMDA receptorN methyl D aspartate receptors
A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor—neuronal protein interaction. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity, ischemic and traumatic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95 / NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults, dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia, and traumatic brain injury (TBI) in rats.
Owner:NONO INC
Anti-pd-1 antibody and use thereof
This invention provides antibodies or functional fragments thereof that bind to PD-1 with high affinity. The invention provides nucleic acid molecules encoding the antibodies or the fragments thereof according to the present invention, expression vectors and host cells for expressing the antibodies or the functional fragments thereof according to the present invention, as well as methods for producing the antibodies or the functional fragments thereof according to the present invention. The present invention also provides immunoconjugates and pharmaceutical compositions comprising the antibodies or the functional fragments thereof according to the present invention. The present invention additionally provides methods for treating a plurality of diseases (comprising cancers, infectious diseases and inflammatory diseases) by using the antibodies or the functional fragments thereof disclosed herein.
Owner:JUNMENG BIOSCIENCES CO LTD +1
Antibodies against CD38 for treatment of multiple myeloma
ActiveUS7829673B2Compounds screening/testingSenses disorderAntiendomysial antibodiesPharmaceutical drug
Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Owner:GENMAB AS
Delivery of highly lipophilic agents via medical devices
InactiveUS20060240070A1Easy to transportIncrease drug retentionBiocideFibrinogenMedicineMedical device
An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent / medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and / or preventing adjacent diseases or maintaining patency of the body lumen.
Owner:ABBOTT LAB INC
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