2652results about How to "Generate efficiently" patented technology

The invention provides immunoglobulin polypeptides comprising variant amino acids in CDRs of antibody variable domains. In one embodiment, the polypeptide is a variable domain of a monobody and has a variant CDRH3 region. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

The invention provides polypeptides comprising a variant heavy chain variable framework domain (VFR). In some embodiments, the amino acids defining the VFR form a loop of an antigen binding pocket. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR. The polypeptide may optionally comprise one or more complementary determining regions (CDRs) of antibody variable domains. In an embodiment, the polypeptide is a variable domain of a monobody and has a variant VFR and one or more variant CDRs. Libraries of polypeptides that include a plurality of different antibody variable domains generated by creating diversity in a VFR, and optionally, one or more CDRs are provided and may be used as a source for identifying novel antigen binding polypeptides that can be used therapeutically or as reagents. The invention also provides fusion polypeptides, compositions, and methods for generating and using the polypeptides and libraries.

A transistor device (10), the transistor device (10) comprising a substrate (11, 14), a fin (3, 3A) aligned along a horizontal direction on the substrate (11, 14), a first source / drain region (4) of a first type of conductivity in the fin (3, 3A), a second source / drain region (5) of a second type of conductivity in the fin (3, 3A), wherein the first type of conductivity differs from the second type of conductivity, a channel region (33) in the fin (3, 3A) between the first source / drain region (4) and the second source / drain region (5), a gate insulator (6) on the channel region (33), and a gate structure (7, 8) on the gate insulator (6), wherein the sequence of the first source / drain region (4), the channel region (33) and the second source / drain region (5) is aligned along the horizontal direction.

A heat treatment jig for supporting silicon semiconductor substrates by contacting, being loaded onto a heat treatment boat in a vertical heat treatment furnace, comprises; the configuration of a ring or a disc structure with the wall thickness between 1.5 and 6.0 mm; the deflection displacement of 100 μm or less at contact region in loaded condition; the outer diameter which is 65% or more of the diameter of said substrate; and the surface roughness (Ra) of between 1.0 and 100 μm at the contact region. The use of said jig enables to effectively retard the slip generation and to avoid the growth hindrance of thermally oxidized film at the back surface of said substrate, diminishing the surface steps causing the defocus in photolithography step in device fabrication process, thereby enabling to maintain high quality of silicon semiconductor substrates and to substantially enhance the device yield.

An efficient method of generating a bit-reverse index array in real time without performing any bit manipulation for a wireless communication system.

A heat treatment jig for supporting silicon semiconductor substrates by contacting, being loaded onto a heat treatment boat in a vertical heat treatment furnace, comprises; the configuration of a ring or a disc structure with the wall thickness between 1.5 and 6.0 mm; the deflection displacement of 100 μm or less at contact region in loaded condition; the outer diameter which is 65% or more of the diameter of said substrate; and the surface roughness (Ra) of between 1.0 and 100 μm at the contact region. The use of said jig enables to effectively retard the slip generation and to avoid the growth hindrance of thermally oxidized film at the back surface of said substrate, diminishing the surface steps causing the defocus in photolithography step in device fabrication process, thereby enabling to maintain high quality of silicon semiconductor substrates and to substantially enhance the device yield.

A method is disclosed for designing a coordinated content management and delivery system, using key considerations related to the client environment, and using key processes, and applying these to the design problem with the assistance of a template showing basic content management and delivery element relationships, whereby such a system can be implemented wherein coherent sales, training or marketing campaigns may be efficiently generated to web-based and other clients.

The present invention refers to synthetic antibody molecules which comprise domains from naturally occuring antibodies, e.g. domains derivable from IgG, preferably of human origin, in a novel arrangement. Single chain molecules are provided which are suitable for expression in micro-organisms in their active conformation, which single chain molecules generally comprise a VL domain, a CL domain, and a VH domain, a CH1 domain, linked by a linker arranged between VUCL and VH / CH1. Accordingly, these antibody molecules can be termed single chain Fabs (scFabs). These antibody molecules are single chain proteins, which can also be associated to dimers, including heteromeric antibodies, wherein at least two single chain antibody molecules are associated.

Devices and methods for the treatment of skin conditions and lesions are disclosed herein. A compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices employ the application of ultrasound energy and heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 40° C. to about 70° C. by the devices, are achieved in less than about 20 second, and maintained for less than about 40 second. Ultrasound absorption and thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.

A high frequency reaction processing system comprising an outer container (40) made of a dielictric material and having two end faces, which can close the inner cavity, one or more high frequency wave coupling portion (42) disposed at arbitrary position on the outer surface of the outer container (40), one or more inner container (41) made of a dielectric material and having two end faces, which can closeg the inner cavity, disposed at a position for receiving a high frequency wave guided through the high frequency wave coupling portion (42) without touching the inner side face of the outer container (40), and a covering portion (43) made of a conductive material, for covering the outer surface of the outer container except for the area occupied with the high frequency wave coupling portion (42) and sustaining the potential at a level equal to the ground potential of a waveguide line.

A path planning system and method for an object, such as a vehicle, provides a randomized adaptive path planning that handles real-time path planning for a vehicle operating under kinodynamic constraints in dynamically changing and uncertain environments with probabilistic knowledge of vehicle and obstacle movement.

A graphical user interface and method for creating a mapping between a source object and a destination or target object are provided. The user interface includes a source screen region which displays a graphical representation of a source object, a target screen region which displays a graphical representation of a target object, and a mapping screen region which allows a user to create a mapping between the graphical representation of the source object and the graphical representation of the target object using graphical mapping indicia. The methodology includes displaying a graphical representation of a source object in a source screen region, displaying a graphical representation of a target object in a target screen region, creating a mapping between the graphical representation of the source object and the graphical representation of the target object in a mapping screen region using graphical mapping indicia, and displaying the mapping in the mapping screen region. The source and target objects may be schemas, spreadsheets, documents, databases, or other information sources, and the graphical mapping indicia may include link indicia and / or function objects linking nodes in the target object with nodes in the source object. The mapping may be compiled into code used by a runtime engine to translate source documents into target documents.

A distributed network method for self-organizing a group of nodes into a bi-directional communication network where initially there is no central coordinator in the prospective network environment. The method involves engaging in the process of determining internodal communication capabilities en route to creating a network topology table, and then using that table as a guide (a) selecting, by nodal election, an appropriate central coordinator, and (b) establishing proxy nodes which enable full network bi-directional communication between all nodes, including otherwise communicatively-compromised hidden nodes.

A system and method for generating trick play video streams, such as fast forward and fast reverse video streams, from an MPEG compressed normal play bitstream. The system receives a compressed normal play bitstream and filters the bitstream by extracting and saving only portions of the bitstream. The system preferably extracts I-frames and sequence headers, including all weighting matrices, from the MPEG bitstream and stores this information in a new file. The system then assembles or collates the filtered data into the proper order to generate a single assembled bitstream. The system also ensures that the weighting matrixes properly correspond to the respective I-frames. This produces a bitstream comprised of a plurality of sequence headers and I-frames. This assembled bitstream is MPEG-2 decoded to produce a new video sequence which comprises only one out of every X pictures of the original, uncompressed normal play bitstream. This output picture stream is then re-encoded with respective MPEG parameters desired for the trickplay stream, thus producing a trickplay stream that is a valid MPEG encoded stream, but which includes only one of every X frames. The present invention thus generates compressed trick play video streams which require reduced storage and reduced data transfer bandwidth requirements.

This invention constructs an antenna matching circuit able to avoid a bad influence when a conductor, such as a metal, or tag, approaches a reader / writer, and dissolves a communication defect area on the reader / writer and stably maintains a communication distance. In this invention, in a RFID system, when the tag corresponds to the generating area of a magnetic field of the reader / writer, a radio wave for sending information to the reader / writer is outputted by operating a control circuit of the tag by electric power generated in an antenna coil of this corresponding tag. A conductor is arranged near the antenna coil of the reader / writer and an eddy current is intentionally flowed. Thus, the communication defect between the reader / writer and the tag approaching this reader / writer is reduced.

A WIFI-enabled and GPS-enabled user device executes a hotspot location utility, which enables the device to detect WIFI hotspots and update a locally-stored hotspot location database (LHLD) containing geographically-mapped hotspots. When a hotspot is detected, the device accesses the hotspot, retrieves identification information and usage terms from the hotspot, and measures performance metrics of the hotspot. The utility stores the identified hotspot with the current GPS coordinate as an entry within the LHLD. When a user later desires to locate hotspots within a particular geographic location, the user enters the physical address of the location, and hotspots with matching (or proximate) GPS coordinates of the entered address are presented to the user. The user may specify certain preferences for usage terms, performance metrics, and location criteria, and the utility filters all geographic hits and returns only hotspots in the geographic location that also satisfy these preferences.

Techniques are disclosed for programmatically generating class libraries to represent the messages which may be sent / received according to specifications provided in a structured language message definition schema (or its equivalent, alternatively, such as a Document Type Definition or "DTD"). The disclosed techniques are very flexible, and are not limited to a single output programming language. Instead, a template-driven approach can be used to guide the generation process, where templates for multiple programming languages may be used to generate different versions of a class library, one for each programming language. The generation process can also be directed by rules specified in a rules file. The disclosed techniques can be used to generate class libraries for web services which have a service interface defined using only a schema reference. Migration can be evaluated programmatically, enabling much easier resolution of migration issues than is possible using prior art manual migration techniques.

When 3D viewing means become much more available and common, it will be very sad that the many great movies that exist today will be able to be viewed in 3D only through limited and partial software attempts to recreate the 3D info. Films today are not filmed in 3D due to various problems, and mainly since a normal stereo camera could be very problematic when filming modern films, since for example it does not behave properly when zooming in or out is used, and it can cause many problems when filming for example smaller scale models for some special effects. For example, a larger zoom requires a correspondingly larger distance between the lenses, so that for example if a car is photographed at a zoom factor of 1:10, the correct right-left disparity will be achieved only if the lenses move to an inter-ocular distance of for example 65 cm instead of the normal 6.5 cm. The present invention tries to solve the above problems by using a 3D camera which can automatically adjust in a way that solves the zoom problem, and provides a solution also for filming smaller models. The angle between the two lenses is preferably changed according to the distance and position of the object that is at the center of focus, and changing the zoom affects automatically both the distance between the lenses and their angle, since changing merely the distance without changing the convergence angle would cause the two cameras to see completely different parts of the image. The patent also shows that similar methods can be used for example for a much better stereoscopic telescope with or without a varying zoom factor. In addition, the patent shows various ways to generate efficiently a 3D knowledge of the surrounding space, which can be used also for example in robots for various purposes, and also describes a few possible improvements in 3d viewing.

A framework for comparison and optimization of classifiers and features for classification of targets includes preparing training and testing sets, applying a classifier to the training set to achieve a distinctly trained classifier for each classifier applied, applying each resulting trained classifier to the testing data set, selecting an optimal classifier, and applying the optimal classifier to the target. The framework is used to optimally classify a physical representation of a target, such as a document, news article, or advertisement. The framework allows for targeted advertisements to be directed to consumers based on user preferences learned from user activities across a network.

The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

A fan assembly includes a motor-driven impeller for creating an air flow, at least one heater for heating a first portion of the air flow, and a casing comprising at least one air outlet for emitting the first portion of the air flow, and first channel means for conveying the first portion of the air flow to said at least one air outlet. To cool part of the casing, the casing includes means for diverting a second portion of the air flow away from said at least one heater, and second channel means for conveying the second portion of the air flow along an internal surface of the casing. This second portion of the air flow may merge with the first portion within the casing, or it may be emitted through at least one second air outlet of the casing.

A fan assembly includes a motor-driven impeller for creating an air flow, a casing including an interior passage for receiving the air flow, and a plurality of air outlets for emitting the air flow from the casing. The casing defines and extends about an opening through which air from outside the casing is drawn by the air flow emitted from the air outlets. The fan assembly also includes at least one heater for heating at least a first portion of the air flow, and means for diverting at least a second portion of the air flow away from said at least one heater. The plurality of outlets includes at least one first air outlet for emitting the relatively hot first portion of the air flow and at least one second air outlet for emitting the relatively cold second portion of the air flow.

A fan assembly includes a motor-driven impeller for creating an air flow, at least one heater for heating a first portion of the air flow, means for diverting a second portion of the air flow away from said at least one heater, and a casing comprising at least one first air outlet for emitting the first portion of the air flow and at least one second air outlet from emitting the second portion of the air flow. To cool an external surface of the casing, at least one second air outlet is arranged to direct at least part of the second portion of the air flow over the external surface.

The invention provides comprising variant amino acids in CDRs of antibody variable domains. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags, and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

A system and method for efficiently generating cluster groupings in a multi-dimensional concept space is described. A plurality of terms is extracted from each document in a collection of stored unstructured documents. A concept space is built over the document collection. Terms substantially correlated between a plurality of documents within the document collection are identified. Each correlated term is expressed as a vector mapped along an angle θ originating from a common axis in the concept space. A difference between the angle θ for each document and an angle σ for each cluster within the concept space is determined. Each such cluster is populated with those documents having such difference between the angle θ for each such document and the angle σ for each such cluster falling within a predetermined variance. A new cluster is created within the concept space those documents having such difference between the angle θ for each such document and the angle σ for each such cluster falling outside the predetermined variance.

The present invention is related to systems and methods for adding a signature to circuit design. In one embodiment, a first set of constraints used to specify a functional portion of the circuit design is received. A second set of constraints used to specify the signature is received as well. The circuit design is generated based on at least the first constraints and the second constraints, wherein the signature is embedded in the functional portion.

A bladeless fan assembly includes a nozzle mounted on a base housing a motor and an impeller driven by the motor for creating an air flow. The nozzle includes an interior passage for receiving the air flow, a mouth for emitting the air flow, and a plurality of stationary guide vanes located within the interior passage and each for directing a portion of the air flow towards the mouth. The nozzle defines an opening through which air from outside the fan assembly is drawn by the air flow emitted from the mouth.

A background noise estimate based upon a modified Doblinger noise estimate is used for modulating the output of a pseudo-random phase spectrum generator to produce the comfort noise. The circuit for estimating noise includes a smoothing filter having a slower time constant for updating the noise estimate during noise than during speech. Comfort noise is smoothly inserted by basing the amount of comfort noise on the amount of noise suppression. A discrete inverse Fourier transform converts the comfort noise back to the time domain and overlapping windows eliminate artifacts that may have been produced during processing.