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1310 results about "Single-Chain Antibodies" patented technology
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A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Antibody
InactiveUS20070274985A1Generate efficientlyEffective isolationAntibody mimetics/scaffoldsImmunoglobulins against animals/humansNatural antibodySingle-Chain Antibodies
The present invention refers to synthetic antibody molecules which comprise domains from naturally occuring antibodies, e.g. domains derivable from IgG, preferably of human origin, in a novel arrangement. Single chain molecules are provided which are suitable for expression in micro-organisms in their active conformation, which single chain molecules generally comprise a VL domain, a CL domain, and a VH domain, a CH1 domain, linked by a linker arranged between VUCL and VH / CH1. Accordingly, these antibody molecules can be termed single chain Fabs (scFabs). These antibody molecules are single chain proteins, which can also be associated to dimers, including heteromeric antibodies, wherein at least two single chain antibody molecules are associated.
Owner:TECH UNIV BRAUNSCHWEIG
Tumour necrosis factor antibodies
InactiveUS6451983B2Enhance or inhibit TNF alpha activityInduction of endothelial procoagulant activityPeptide/protein ingredientsAntibody mimetics/scaffoldsHuman tumorSingle-Chain Antibodies
The present invention relates to ligands which bind to human tumor necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the induction of endothelial procoagulant activity of the TNF is inhibited; the binding of TNF to receptors on endothelial cells is inhibited; the induction of fibrin deposition in the tumor and tumor regression activities of the TNF are enhanced; and the cytotoxicity and receptor binding activities of the TNF are unaffected or enhanced on tumor cells. The ligand is preferably an antibody, F(ab) fragment, single domain antibody (dABs) single chain antibody or a serum binding protein. It is preferred, however, that the ligand is a monoclonal antibody or F(ab) fragment thereof.
Owner:CEPHALON AUSTRALIA
Antibodies to insulin-like growth factor I receptor
Owner:AMGEN FREMONT INC +1
Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
InactiveUS20130084243A1High affinityUseful in detectionAnimal cellsIn-vivo radioactive preparationsDiseaseSingle-Chain Antibodies
The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGf-1R.
Owner:GOETSCH LILIANE +4
Expression of heterologous multi-domain proteins in yeast
InactiveUS6358733B1Increase productionCost effective productionSugar derivativesAntibody mimetics/scaffoldsYeastSingle-Chain Antibodies
This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the inclusion of a plurality of (up to three) modular expression cassettes which may encode multiple polypeptide chains of a heterologous multi-domain protein on a single plasmid (Twin Cassette). Because multiple polypeptide chains may be encoded for by the expression cassettes of the present invention in a single vector, the system can produce equivalent amounts of the multiple polypeptide chains, thereby enhancing the yield of a functional heterologous multi-domain protein. For example, functional monoclonal antibodies (MAbs) comprising a heavy chain and a light chain of an immunoglobulin (IgG), and functional immunotoxins comprising an antibody domain and an oxidase toxin may be produced using the Yeast expression system of the present invention. In addition, functional single chain antibodies, antibody fragments and chimeric antibodies may also be produced.
Owner:APOLIFE
Bispecific antibody to VEGF/PDGFR beta and application thereof
InactiveCN102250246AInhibition of newbornsGood tumor activityHybrid immunoglobulinsAntibody ingredientsSingle-Chain AntibodiesBispecific monoclonal antibody
The invention relates to a medicine of a bispecific monoclonal antibody, and especially to a medicine of a bispecific monoclonal antibody to human vascular endothelial growth factor (VEGF / VEGF-A) and platelet-derived growth factor receptor (PDGFR) for resistance to angiogenesis of tumor. The bispecific antibody to VEGF / PDGFR beta provided in the invention is characterized in that: a monoclonal antibody to VEGF is used as the base for the antibody and a single chain antibody to PDGFR beta is connected with the terminal of FC segment of the monoclonal antibody to VEGF to form the bispecific antibody to VEGF / PDGFR beta. The bispecific antibody related to in the invention is obtained by employing technical means like gene engineering and constructing antibody segments which identify VEGF and PDGFR beta in a same antibody molecule that can be specifically bound with the two antibody segments; the effect of the bispecific antibody on inhibiting angiogenesis of tumor issue is obviously superior to that of a single antibody to VEGF; and the bispecific antibody has good activity in resisting tumors.
Owner:CHANGZHOU ADAM BIOTECH
Bispecific single chain FV antibody molecules and methods of use thereof
InactiveUS20060099205A1Stable growthIn-vivo radioactive preparationsBiological material analysisSingle-Chain AntibodiesProtein family
Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.
Owner:INST FOR CANCER RES +1
Human antibodies specific to KDR and uses thereof
The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal.
Owner:IMCLONE SYSTEMS
Antibodies specific to KDR and uses thereof
InactiveUS20050214860A1Inhibit tumor growthCompound screeningVirusesSingle-Chain AntibodiesAngiogenesis growth factor
The invention provides an immunoglobulin molecule which binds KDR with an affinity comparable to human VEGF, and that neutralizes activation of KDR. Immunoglobulin molecules include monovalent single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, antibodies, humanized antibodies and chimerized antibodies. The invention further provides nucleic acid molecules that encode these immunoglobulin molecules. The invention also provides a method of making the immunoglobulin molecules mentioned above. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal with such immunoglobulin molecules.
Owner:ZHU ZHENPING +1
Bispecific single chain Fv antibody molecules and methods of use thereof
InactiveUS7332580B2Immunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsAntibody moleculeSingle-Chain Antibodies
Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.
Owner:INST FOR CANCER RES +1
Anti-MUC-1 single chain antibodies for tumor targeting
InactiveUS7183388B2Easy to addImprove stabilityTumor rejection antigen precursorsTumor specific antigensAntigenSingle-Chain Antibodies
Owner:RGT UNIV OF CALIFORNIA
Antibodies to M-CSF
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and / or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention.
Owner:WARNER LAMBERT CO LLC +1
Human anti-epidermal growth factor receptor antibody
ActiveUS7598350B2Neutralize EGFRInhibit bindingSugar derivativesImmunoglobulins against cell receptors/antigens/surface-determinantsSingle-Chain AntibodiesHuman epidermal growth factor receptor
Owner:IMCLONE SYSTEMS
Bispecific single chain Fv antibody molecules and methods of use thereof
InactiveUS7332585B2Stable growthIn-vivo radioactive preparationsBiological material analysisSingle-Chain AntibodiesProtein family
Owner:INST FOR CANCER RES +1
Antibodies to c-Met
ActiveUS7498420B2Immunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsSingle-Chain AntibodiesHeavy chain
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and / or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
Owner:AMGEN FREMONT INC +1
Immunosensors: scFv-linker design for surface immobilization
InactiveUS20110201032A1Bioreactor/fermenter combinationsMaterial nanotechnologySingle-Chain AntibodiesSide chain
An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as Staphylococcus aureus having protein A or protein G.
Owner:OAKLAND UNIVESITY +1
Antibodies to c-Met
ActiveUS20100040629A1Immunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsSingle-Chain AntibodiesHeavy chain
Owner:AMGEN FREMONT INC +1
Look-through mutagenesis
InactiveUS20050136428A1Highly efficient and accurate systematic evaluationImproving overall structure and functionPeptide librariesHydrolasesSingle-Chain AntibodiesAntibody fragments
A method of mutagenesis by which a predetermined amino acid is introduced into each and every position of a selected set of positions in a preselected region (or several different regions) of a polypeptide to produce a library of polypeptide analogs. The method is based on the premise that certain amino acids play crucial role in the structure and function of proteins. Libraries can be generated which contain only desired polypeptide analogs and are of reasonable size for screening. The libraries can be used to study the role of specific amino acids in polypeptide structure and function and to develop new or improved polypeptides such as antibodies, antibody fragments, single chain antibodies, enzymes, and ligands.
Owner:BIOREN
IGF-1R specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
InactiveUS8344112B2Useful in detectionConveniently assayedBiological material analysisAntibody ingredientsDiseaseSingle-Chain Antibodies
The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGF-1R.
Owner:MERCK SHARP & DOHME CORP +1
Capsid-modified recombinant adenovirus and methods of use
InactiveUS6955808B2Low yieldEfficiencyBiocideAntibody mimetics/scaffoldsSingle-Chain AntibodiesNoninvasive imaging
The present invention describes recombinant adenoviral vectors modified by incorporating targeting ligands or label into viral capsid or structural proteins. In one embodiment, single-chain antibody was introduced into the minor capsid proteins pIIIa or pIX so that the adenoviral vector can be targeted to a particular cell type. In another embodiment, there is provided a noninvasive imaging strategy useful for monitoring the replication and spread of conditionally replicative adenoviral vectors. Viral structural proteins such as pIX capsid protein, core proteins mu, V and VII were expressed as fusion protein with a fluorescent label. Once incorporated into the virions, detection of the structural fusion protein label would indicate the localization of the disseminated viral progeny. The detected fluorescent signals also closely correlate with the level of viral replication and progeny production.
Owner:UAB RES FOUND
Human monoclonal antibodies to interleukin-5
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to interleukin 5 (IL-5), which is preferably human IL-5. The invention also relates to human anti-IL-5 antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IL-5 antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IL-5 antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and / or light immunoglobulin molecules that comprise the human anti-IL-5 antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
Owner:MERCK SHARP & DOHME LLC +1
Chimeric antigen receptor of targeted GPC3 (Glypican 3) and application thereof
The invention relates to a chimeric antigen receptor of a targeted GPC3 (Glypican 3) and an application thereof. Specifically, the invention provides a polynucleotide sequence, wherein the polynucleotide sequence is selected from: polynucleotide sequences (1) containing a coding sequence of a CD8 antigen leading peptide, a coding sequence of an anti-GPC3 single-chain antibody, a coding sequence of a human CD8 alpha hinge region, a coding sequence of a human CD8 transmembrane region, a coding sequence of a human 41BB intracellular region, and a coding sequence of a human CD3 zeta intracellular region, and a coding sequence of an optional fragment of an EGFR (Epidermal Growth Factor Receptor) sequence containing an extracellular domain III and an extracellular domain IV, wherein the coding sequences are sequentially connected; and complementary sequences (2) of the polynucleotide sequences (1). The invention provides a CAR (chimeric antigen receptor) coded by the polynucleotide sequences and a T cell expressing the CAR. The prepared CAR-T cell has a function of strongly killing a specific tumor cell, and the kill effectiveness is more than 90% under the condition that the effector-target ratio is 20:1.
Owner:HRAIN BIOTECHNOLOGY CO LTD
An anti-glypican-3 antibody and an application thereof
Owner:CARSGEN THERAPEUTICS
High throughput generation of human monoclonal antibody against peptide fragments derived from membrane proteins
InactiveUS20030165988A1FungiAntibody mimetics/scaffoldsHigh-Throughput Screening MethodsSingle-Chain Antibodies
Methods are provided for efficient, high throughput screening of antibody libraries against proteins targets, especially membrane proteins. In particular, methods are provided for screening a fully human antibody library against membrane proteins such as HIV coreceptors in yeast. More particularly, a library of human single chain antibodies is screened against peptide fragments derived from extracellular domains of human CCR5 and high affinity monoclonal antibodies against CCR5 are selected.
Owner:GENETASTIX CORP
Chimeric antigen receptor and its use
InactiveCN103145849ASpeed up entryGood treatment effectGenetic material ingredientsAntiviralsLatent Membrane Protein-1Single-Chain Antibodies
The invention belongs to the biotechnical field of tumors, and discloses a preparation method of a chimeric antigen receptor and an application of the chimeric antigen receptor. The chimeric antigen receptor is formed through the structural series connection of a single chain antibody of a human anti-EB virus latent membrane protein 1, CH2CH3 of a human antibody IgG1, and intracellular signals of immune co-stimulating signal molecules CD28, CD134 and CD3zeta. The chimeric antigen receptor is used for modifying T lymphocytes, and the modified lymphocytes can be used for treating EB virus related tumors and preparing EB virus related tumor resisting medicines.
Owner:SINOBIOWAY CELL THERAPY CO LTD
Antibodies to insulin-like growth factor I receptor
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and / or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
Owner:AMGEN FREMONT INC +1
Method of generating single vl domain antibodies in transgenic animals
InactiveUS20110123527A1Antibody mimetics/scaffoldsFermentationSingle-Chain AntibodiesVariable domain
The present invention describes methods of generating single VL domain antibodies, including chimeric single chain antibodies that comprise of a variable region of a human immunoglobulin κ or λ light chain and a non-human constant region. The non-human constant region is devoid of a first constant domain CH1, and the variable region is devoid of a heavy chain variable domain.
Owner:ABLEXIS LLC
Chimeric antigen receptors and immune cells targeting b cell malignancies
The disclosure describes genetically engineered CD37 specific redirected immune effector cells expressing a chimeric antigen receptor (CAR) protein comprising an antigen binding domain derived from an antibody, a single chain antibody or portion thereof that binds CD37; a hinge region; a transmembrane domain and an intracellular signaling domain derived from human CD3ζ or FcRγ; and optionally one or more co-stimulatory intracellular signaling domains The invention includes nucleic acids, vectors and immune effector cells associated with the production of the CAR protein, as well as methods of treating B cell malignancies in humans by cellular immunotherapy.
Owner:BLUEBIRD BIO INC
Anti-BCMA chimeric antigen receptor, encoding gene, recombinant expression vector and establishing method and application of anti-BCMA chimeric antigen receptor, encoding gene and recombinant expression vector
ActiveCN105777911AImprove in vitro killing effectGood clinical effectPeptide/protein ingredientsImmunoglobulins against cell receptors/antigens/surface-determinantsSequence signalSingle-Chain Antibodies
The invention discloses an anti-BCMA chimeric antigen receptor, an encoding gene, a recombinant expression vector and an establishing method and application of the anti-BCMA chimeric antigen receptor, the encoding gene and the recombinant expression vector. The receptor comprises a CD8 leader chimeric receptor signal peptide, a BCMA single-chain antibody heavy chain VH, an Optimal Linker C, a BCMA single-chain antibody light chain VL, a CD8 Hinge chimeric receptor hinge, a CD8 Transmembrane chimeric receptor transmembrane domain, a CD137 chimeric receptor co-stimulatory factor and a TCR chimeric receptor T cell activating domain which are sequentially connected in series. In addition, the invention further discloses the encoding gene and the recombinant expression vector of the anti-BCMA chimeric antigen receptor and the establishing method and application of the encoding gene and the recombinant expression vector. The secretion of cell factors and the cytotoxicity in vitro of CAR-T cells can be remarkably improved, and the clinical treatment effect is outstanding.
Owner:SHANGHAI UNICAR THERAPY BIOPHARM TECH CO LTD
Intrabody-mediated control of immune reactions
InactiveUS20060034834A1Inhibit expressionVirusesPeptide/protein ingredientsSingle-Chain AntibodiesPlatelet
The present invention is directed to methods of altering the regulation of the immune system, e.g., by selectively targeting individual or classes of immunomodulatory receptor molecules (IRMs) on cells comprising transducing the cells with an intracellularly expressed antibody, or intrabody, against the IRMs. In a preferred embodiment the intrabody comprises a single chain antibody against an IRM, e.g, MHC-1 molecules.
Owner:DANA FARBER CANCER INST INC
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