542results about How to "Cost effective production" patented technology

The blockable bone plate consists of a plurality of plate members which are connected to each other via webs. A screw hole is provided in at least some plate members, preferably in each plate member. The screw hole is surrounded by a spherical countersink on the upper surface of the plate. Provided internally in the screw hole there is an engagement contour which consists of contour valleys and contour peaks partially running in a horizontal and radial peripheral direction on the wall of the screw hole. The engagement contour is preferably produced by milling and has for example a pointed, round, trapezoidal or serrated configuration. A blocking thread is provided under the screw head of the screw intended for blocking. As the screw is screwed in, the blocking thread engages in the engagement contour. The particular advantages lie in increased security against the screw coming loose and in the possibility of also inserting the screw through the plate at an inclination. Furthermore, a bone plate is proposed which has the shape of an arc of a circle in the longitudinal axis of the plate and which requires less bending, particularly on the human lower jaw, and adapts to the bone in a more ideal manner.

The present invention relates to catalyst-loaded coal compositions having a moisture content of less than about 6 wt %, a process for the preparation of catalyst-loaded coal compositions, and an integrated process for the gasification of the catalyst-loaded coal compositions. The catalyst-loaded coal compositions can be prepared by a diffusive catalyst loading process that provides for a highly dispersed catalyst that is predominantly associated with the coal matrix, such as by ion-exchange.

A golf club (40) having a club head (42) with a face component (60), an aft body (61) and a gasket (300) is disclosed herein. The face component (60) has a striking plate portion (72) and a return portion (74). The aft-body (61) is preferably composed of a crown portion (62), a sole portion (64) and optionally a ribbon section (90). The gasket (300) provides an interface between the face (60) and the aft-body (61) that reduces corrosion and improves manufacturing costs of the club head. The club head (42) preferably has a volume in the range of 290 cubic centimeters to 600 cubic centimeters, a weight in the range of 165 grams to 300 grams, and a striking plate portion (72) surface area in the range of 4.00 square inches to 7.50 square inches.

An optical spectroscopy apparatus determines the concentration of analyte in a specimen that utilizes a single radiation source which is hybrid laser comprising a semiconductor pump laser and small-cavity rare earth fiber laser where laser cavities of both lasers are butt coupled or otherwise optically coupled to form a plurality of laser cavities that produce a plurality of emission wavelengths, one which may be the pump laser emission wavelength at the output of the fiber laser thereby forming a multi-wavelength combined output where the wavelengths substantially match distinguishing spectral characteristic features along at least a portion of a characteristic optical spectrum of the analyte under examination. In lieu of complex data analysis of these wavelengths to determine values representing the concentration of the analyte in an examined specimen, the semiconductor pump laser or lasers are modulated as a plurality of tone frequencies, where at least a first of the modulation frequencies is below the maximum frequency response of the fiber laser so that the first modulation effectively modulates the pump emission wavelength and a first emission wavelength of the fiber laser in the hybrid laser combined output, and at least a second of modulation frequencies is above the maximum frequency response of the fiber laser so that the second modulation effectively modulates the pump emission wavelength but not the first emission wavelength of the fiber laser in the hybrid laser combined output. Further, one or more additional modulation frequencies may be applied to the pump laser which are intermediate of the first and second modulation frequencies where it is at least responsive to at least one further emission wavelength of the fiber laser and also provided in the hybrid laser combined output.

This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the inclusion of a plurality of (up to three) modular expression cassettes which may encode multiple polypeptide chains of a heterologous multi-domain protein on a single plasmid (Twin Cassette). Because multiple polypeptide chains may be encoded for by the expression cassettes of the present invention in a single vector, the system can produce equivalent amounts of the multiple polypeptide chains, thereby enhancing the yield of a functional heterologous multi-domain protein. For example, functional monoclonal antibodies (MAbs) comprising a heavy chain and a light chain of an immunoglobulin (IgG), and functional immunotoxins comprising an antibody domain and an oxidase toxin may be produced using the Yeast expression system of the present invention. In addition, functional single chain antibodies, antibody fragments and chimeric antibodies may also be produced.

PCT No. PCT / DE98 / 00827 Sec. 371 Date Nov. 17, 1998 Sec. 102(e) Date Nov. 17, 1998 PCT Filed Mar. 20, 1998 PCT Pub. No. WO98 / 43277 PCT Pub. Date Oct. 1, 1998A flat fluorescent lamp (1) has a discharge vessel (2) having a base plate (7), a top plate (8) and a frame (9) which are connected to one another in a gas-tight fashion by means of solder (10). Structures resembling conductor tracks function in the interior of the discharge vessel as electrodes (3-6), in the feedthrough region as feedthroughs, and in the external region as external supply leads (13; 14). Flat lamps of the most different sizes can thereby be produced simply in engineering terms and in a fashion capable of effective automation. Moreover, virtually any electrode shapes can be realized, in particular optimized with regard to a uniform luminous density with a reduced drop in luminous density towards the edges of the flat lamp. At least the anodes (5, 6) are covered in each case with a dielectric layer (15). The lamp (1) is preferably operated by means of a pulsed voltage source and serves as background lighting for LCDs, for example in monitors or driver information displays.

The invention concerns a method for production of a three-dimensional body by successively providing powder layers and fusing together of selected areas of said layers, which areas correspond to successive cross sections of the three-dimensional body, wherein the method comprises the following steps for at least one of said layers: applying the at least one powder layer onto a working area, and fusing together a selected area of the at least one powder layer by supplying energy from a radiation gun to the selected area. The invention is characterized in that it comprises the steps of: establishing an intended beam path that is to be used when fusing together the selected area of the at least one powder layer, calculating a temperature in the at least one powder layer along the intended beam path as a function of a specific energy deposition of an imaginary beam that is assumed to move along the intended beam path, adjusting the specific energy deposition of the imaginary beam along the intended beam path depending on the calculated temperature and on conditions set for the step of fusing together the selected area, and providing, based on the calculations and the adjustments, an operating scheme for the specific energy deposition of the real beam to be used for the intended beam path when fusing together the selected area of the at least one layer.

A use in a medical device of at least one salt of organic acid(s), and preferably a benzoate or a sorbate, as an antimicrobial agent is disclosed, and in particular for the manufacturing of an antimicrobial coating for a medical device for the prevention of bacterial infection. This is very useful in medical devices having a hydrophilic coating, such hydrophilic urinary catheters. It is further preferred that the pH of the hydrophilic coating is controlled to be in the range 4.0-8.0, and preferably in the range 5.0-6.0. It is also preferred that the pH of the hydrophilic coating is controlled to be below 7.0. The pH of the hydrophilic coating could be controlled by means of a pH buffer, and preferably a citrate or phosphate buffer. Specifically, the provision of the salt of organic acid in combination with a pH buffer has proven surprisingly efficient for inhibition of bacterial growth, and for prevention of bacterial infections.

Stocks of infectious rAAV are generated using yeast strains, bacterial strains, and bacteriophages engineered to express the required AAV proteins and harboring rAAV vector sequences. Stocks of rAAV virions of all serotypes and pseudotypes can be generated in prokaryotic and eukaryotic cells using the methods described herein.

Methods and devices are provided for forming an absorber layer. In one embodiment, a method is provided comprising of depositing a precursor material onto a substrate, wherein the precursor material may include or may be used with an additive to minimize concentration of group IIIA material such as Ga in the back portion of the final semiconductor layer. The additive may be a non-copper Group IB additive in elemental or alloy form.

Method for producing zirconia-reinforced Al2O3 grains, including at least the following steps: inductively melting a starting mixture to form a eutectic melt made of alumina and zirconia; applying the eutectic melt as a thin layer material, the thin layer material being quenched; and removing the thin layer material. In this manner abrasive grains can be formed directly or the thin layer material can be classified when it is broken into abrasive grains, the grains are polycrystalline without amorphous glass phases as an alumina matrix having zirconia precipitations, and at least some of the zirconia precipitations can be formed in the nanoscale range.

An optical spectroscopy apparatus determines the concentration of analyte in a specimen that utilizes a single radiation source which is hybrid laser comprising a semiconductor pump laser and small-cavity rare earth fiber laser where laser cavities of both lasers are butt coupled or otherwise optically coupled to form a plurality of laser cavities that produce a plurality of emission wavelengths, one which may be the pump laser emission wavelength at the output of the fiber laser thereby forming a multi-wavelength combined output where the wavelengths substantially match distinguishing spectral characteristic features along at least a portion of a characteristic optical spectrum of the analyte under examination.

This invention is related to lenses and the associated processes used to manufacture lenses. In particular, the present invention is related to a process for designing and creating bifocal, multifocal, and single vision ophthalmic lenses by modulating an energy source.

A single or multiple band quarter wave resonator antenna assembly for a communications device including a resonator element as a substrate element having disposed thereupon at least a pair of conductor trace elements. The conductor trace elements are disposed upon opposite sides of the substrate element and are operatively coupled to the communications device. The antenna assembly further including a separate conductive member having an approximate ¼ wavelength or greater dimension, which may be defined as the internal printed wiring board ground plane of the communications device.

On the basis of a known process for the production of a preform for an optical fiber for optical data transmission technology, the productivity of the process for the production of complex refractive index profiles is to be improved by providing a quartz glass substrate tube which exhibits different doping in radial direction, introducing a core glass made of synthetic quartz glass into the substrate tube and covering the substrate tube with a jacket tube. A substrate tube suitable therefor is also being provided which tube requires less core glass material for the production of the preform, whether during the internal deposition or for the core glass rod in the rod-in-tube technique. Regarding the process it is proposed according to the invention that a substrate tube be used which was obtained by vitrification of a porous tube-shaped SiO2 blank, the substrate tube being provided with a core glass layer which is produced in that to the first radial portion of the SiO2 blank there is added before the vitrification a first dopant which increases the refractive index of quartz glass. The substrate tube according to the invention has in the radial direction regions of different doping whereby it incorporates a core glass layer which has a refractive index of at least 1.459.

The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient in a solid phase, (b) a vehicle consisting substantially of polyol fatty acid esters with a degree of esterification of over 80%, and (c) a wetting agent consisting substantially of polyol fatty acid esters with a monoester proportion of over 60%. The inventive composition is used for the systemic administration of numerous pharmacologically active ingredients, whereby the ingredients are released from the pharmaceutical composition over a period of at least 12, preferably at least 24 hours.

A device displays information in identification areas of traffic signs, signposts, billboards, license plates, etc. The identification area is provided with a surface having an artificially producible base structure and other structures or itself forms such a surface having a self-cleaning effect. The base structure has or develops a capillary effect in which the quotient of capillary work and adhesion work is greater than 1. The capillaries have a negative rise, that is, liquid is pressed form the capillaries, providing the self-cleaning effect.

The present invention relates to novel methods and novel solid support materials for the tandem synthesis of two or more different oligonucleotides on the same solid support in one synthetic run. The methods involve novel support preparations comprised of two or more types of orthogonally protected anchor groups. Subsequent to the selective removal of the first of the respective protective groups, the first oligonucleotide is assembled on the deblocked anchor groups according to standard methods, preferably via phosphoramidite chemistry. Following the capping of said first oligonucleotide, the anchor groups blocked by the second type of protective group are selectively liberated and serve is the starting point for the assembly of a second oligonucleotide, and so forth. After completion of all of the syntheses on the solid support, the oligonucleotides are released from the solid support and deprotected at the nucleobases, using standard methods. Preparations obtained using the method of this invention, generally contain two or more different oligonucleotides. Such preparations are particularly useful in applications that require pairs of oligonucleotide primers, several probes at a time, duplexed nucleic acid fragments, or other combinations of oligonucleotides that are useful in applications such as PCR, sequencing, multiplexed genotyping, cloning and RNA interference. The invention includes procedures for the preparation of the novel solid supports of the invention.

The present invention is related to a process for efficient manufacture of bifocal, multi-focal, single vision and mass customized ophthalmic lenses by modulating an energy source according to a cure period and a cure pattern to create a maximum number of lenses with a minimum number of molds and associated tooling.

Methods for fabricating and manufacturing solid solution perforators (SSPs) using sharp metal or glass needles and / or subsequent molding and use are described. The methods entail making microneedles by various precision machining techniques and micromold structures from curable materials. Various designs of patch, cartridge and applicator are described. Also described are methods for adjusting the microneedle mechanical strength using formulation and / or post-drying processes.

An electric machine, in particular a brushless DC motor, having a stator arrangement and a rotor arrangement that are arranged coaxially with respect to one another, the rotor arrangement having a rotor body and permanent magnets embedded in the rotor body, at least one magnetic sensor for the purpose of measuring the rotational position of the rotor body being disposed at an end face of the rotor body and being located directly opposite this end face

A method for producing an electronic module, in that at least one first microelectronic component is provided and is electrically connected to a second microelectronic component by a first flip-chip method step; at least one dielectric component is provided which has at least one printed circuit trace, and at least one printed circuit trace of the dielectric component is electrically connected to the second microelectronic component; and the second microelectronic component is electrically connected by a second flip-chip method step to a printed circuit board by way of the printed circuit trace(s) of the dielectric component, in order to avoid vias through a microelectronic component; the invention also relates to a corresponding electronic module.

A rotor shaft assembly (101) of a type used in a turbocharger, manufactured by mounting a powder compact of a titanium aluminide rotor (203) to a powder compact of a steel shaft (207), with a metal powder admixed with a binder (211) interposed between the rotor and shaft, and debinding and sintering the mounted compact combination. Sintering produces a strong metallurgical bond between the shaft and rotor, providing a near-net rotor shaft assembly (101) and also an inexpensive and efficient method for the manufacture of an assembly capable of withstanding the high forces and temperatures within a turbocharger.

The present invention describes the use of poly-o-hydroxy amides (PHAs) for adhesively bonding articles or materials, especially components used in the semiconductor industry, such as chips and wafers, a process for adhesively bonding materials, especially chips and / or wafers, chip and / or wafer stacks produced by the process, and adhesive compositions which comprise the poly-o-hydroxy amides of the formula (I).

The present invention relates to a brewing apparatus for extracting a portion capsule, comprising a first brewing chamber element and a second brewing chamber element, the first and / or the second brewing chamber element being movable along an axial direction from a loading position, in which the first and the second brewing chamber element are spaced apart from one another, to an extraction position, in which the first and the second brewing chamber element form a substantially closed brewing chamber, and the brewing apparatus further comprising a drive mechanism for moving the first and / or second brewing chamber element, characterized in that the brewing apparatus has a separate locking mechanism for locking the brewing chamber in the extraction position.

A method of producing metal oxide nanoparticles in an exfoliated silicate framework by forming an aqueous exfoliated silicate suspension by mixing a layered clay into water until clear. To which is added an acidic hydrated metal species precursor solution, formed by dissolving one or more transitional metal salts, and a non-ionic surfactant. This solution is then aged to precipitate a product precursor before the product precursor is separated and washed. The product precursor is calcined to form metal oxide nanoparticles in an exfoliated silicate framework.