2314results about "Microneedles" patented technology

An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and / or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Set forth are vascular valves and servovalves and methods of using the same that may be positioned in the circulatory system without interrupting blood flow to facilitate solid organ transplantation so as to reduce graft organ anoxia and degradation before and after harvesting and storage, thereby minimizing late-term cardiac allograft vasculopathy as a major cause of graft failure. Along the urinary tract, bypassing bladder-generated urge sensation by diverting urine directly from the ureters to a neobladder or collection bag alleviates intractable incontinence, nocturia, urethral syndrome, overactive bladder, dysuria, or frequency. Where the lower tract is missing, a prosthesis can thwart disease and preclude the degenerative metaplastic transition to carcinoma risked when gut is used to construct a conduit for urine, a neobladder, and / or high-maintenance stoma. Druglines to valves and servovalves can directly pipeline-target medication to nidi, anastomoses, or any other trouble spots.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

An optical biomodule for detecting a disease specific biomarker(s) at an early stage, utilizing enhanced fluorescence emission (due to integration of three-dimensional (3-D) structures in a fluidic container) upon chemical binding / coupling of a disease specific biomarker(s) with its corresponding disease specific biomarker binder(s)-coupled with a fluorophore(s) positioned horizontally within a geometrical area (that includes a center region or a middle region) is disclosed. Furthermore, a corresponding disease specific biomarker binder(s) may include an amplifying chemical structure / sequence. The three-dimensional (3-D) structure(s) may be coupled with an optical resonator and / or a photonic crystal (PC) and / or a metamaterial and / or a metamaterial of Epsilon-Near-Zero (ENZ) of a suitable wavelength range.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

The invention relates to a layered drug-loading microneedle patch as well as a preparation method and application thereof. The preparation method of the layered drug-loading microneedle patch comprises the following steps: S1, dissolving a drug and a soluble high-molecular polymer in a solvent according to a mass ratio of (2: 1)-(1: 12) to form a needle tip solution, then filling a needle tip cavity of a microneedle mold with the needle tip solution, drying, and removing redundant drug residues on the surface to form a drug-loading needle tip layer; and S2, filling a mold containing the drug-loading needle tip layer with a photocurable polymer, performing ultraviolet curing for 10-30 seconds under the wavelength of 365-405 nm, and then performing demolding to form a substrate layer, thereby obtaining the layered drug-loading microneedle patch. According to the method, one-time filling of the needle tip part is successfully achieved by combining needle tip auxiliary material proportion optimization, meanwhile, the curing process is rapid, the medicine utilization rate and the process stability are remarkably improved, the medicine stability is good, and the method is suitable for industrial production.

The invention relates to an injection device (100) with needle for injecting a product, in particular a cosmetic product, the device comprising: a suction chamber (1), a support surface (4) inside the chamber (1) at a position set back from the opening (2), and a suction source, the support surface (4) comprising at least one microneedle (6) for carrying out the injection, the suction opening (2) is closed by an intermediate component (7), defining a contact surface with the target area (3), and having at least one orifice (8) designed to be passed through by the microneedle (6), when the target area (3) is suctioned towards the chamber (1).

Provided is a needle roller device for skin injection which includes a main body comprising, formed on one side thereof, an injection pipe part with an injection port to which a drug injection device is detachably coupled, and formed on the other side thereof, an expansion part with predetermined width and length communicating with the injection pipe part, a roller part rotatably coupled to the expansion part, and comprising a plurality of needle protrusions formed on an outer circumferential surface, and fine needles coupled to the plurality of needle protrusions and exposed to outside, and a rotation connection part that fastens the main body and the roller part.

Apparatus comprising a housing, at least one needle arranged for reciprocal motion between a retracted position and an extended position to penetrate an animal tissue surface when in the extended position, and a sealing device defining a channel through which a movable shaft extends to move the at least one needle in the reciprocating motion, wherein the sealing device serves to form a seal between the housing and the movable shaft. A corresponding method of preventing cross-contamination within apparatus for minimally invasive treatment of skin is also disclosed.

The invention relates to the technical field of transdermal drug delivery, in particular to a drug-loaded microneedle, a drug-loaded microneedle patch and an electrically controlled drug release microneedle system.The drug-loaded microneedle comprises a needle body, a drug component and an electric sealing material, the needle body has biocompatibility and conductivity and is a hydrogel microneedle or a porous microneedle, and the drug component is attached to the drug-loaded microneedle patch. The medicine components are doped in the needle body or coated on the outer surface of the needle body. The electric sealing material is doped in the needle body and / or wraps the surface of the needle body, and the electric sealing material is connected with the needle body through at least one of covalent bonds, ionic bonds and coordinate bonds. When the drug-loaded microneedle is inserted into a target tissue, controlled release of drug components can be achieved through an electrical stimulation signal, and active components are guided into the target tissue through electric drive. According to the invention, the ion exchange behavior of the material is controlled through the electric field, so that the opening and closing of a drug release channel are realized, the purpose of electric switching chemical sealing is achieved, reversible control is realized by adjusting the intensity and direction of the electric field, and the accurate opening and closing of drug release are realized.

The invention discloses a double-layer microneedle patch and a preparation method thereof.The preparation method of the double-layer microneedle patch comprises the following steps that firstly, 3D printing is conducted through polydimethylsiloxane, and a PDMS mold similar to a machining microneedle is obtained; dispersing the medicine into the sericin solution to serve as an outer layer solution; dispersing germanium nanoparticles into the polycaprolactone solution to obtain an inner layer solution; and finally, adding the outer-layer solution into the needle-shaped groove of the PDMS mold, so that the needle-shaped groove is filled with the outer-layer solution, drying, adding the inner-layer solution, drying, and demolding to obtain the double-layer microneedle patch. When the double-layer microneedle patch is used for drug delivery, drugs can be dissolved and released in a short time, the inner layer is polycaprolactone (PCL) carrying photo-thermal agent germanium nanoparticles, degradation is slow, a photo-thermal effect is generated under irradiation of 808nm near-infrared light, residual tumor cells are induced to die immunogenicity, an immune microenvironment is programmed in a time sequence, and the double-layer microneedle patch has the advantages of being high in sensitivity, high in sensitivity and good in stability. Postoperative recurrence and metastasis of tumors are efficiently inhibited, and meanwhile operative wound repair is promoted.

The invention provides an intelligent collaborative robot system for microneedle introduction, and relates to the technical field of medical puncture. The skin cuticle thickness, the surface roughness, the hue and other characteristic parameters are obtained through optical scanning and image processing technologies, and the initial puncture depth and the initial puncture frequency are predicted through a deep learning model; in the puncture process, skin humidity, impedance, tissue density and hue changes are monitored in real time, and a depth adjustment index and a frequency adjustment index are generated to adjust the initial puncture depth and the initial puncture frequency. According to the method, real-time sensing of the skin state and accurate regulation and control of puncture parameters are achieved, and the safety of microneedle treatment is remarkably improved.

An applicator for treating acne including one or more microneedles, an optical sensor configured to detect acne, a removal system including a suction mechanism configured to remove acne material, and a chamber for containing the acne material, a remedy system configured apply one or more acne remedies, a light source configured to apply a light therapy to skin, and a processor configured to detect acne at one or more affected areas on skin, and direct the applicator to apply treatment, where the treatment includes penetrating the skin at the one or more affected areas with the one or more microneedles, removing acne material with suction mechanism, applying the light therapy to the one or more affected areas, and applying one or more acne remedies to the one or more affected areas.

The invention discloses a semaglutide soluble microneedle patch composition. The soluble microneedle patch composition comprises a needle body material and a backing layer material, the material of the needle body can be only composed of a high-concentration semaglutide solution. According to the semaglutide micro-needle patch, the drug loading capacity of semaglutide in the micro-needle patch can be greatly improved, the hypoglycemic effect which is the same as that of subcutaneous injection administration can be achieved under the same administration amount, and a new dosage form choice is provided for the pharmaceutical application of semaglutide, such as hypoglycemic weight reduction and the like.

The invention relates to an application of metformin in preparation of skin anti-photoaging drugs or medical instruments. Through verification, the metformin has the effects of promoting the formation of autophagosome, recovering the patency of autophagy flow and remodeling an autophagy-ECM metabolism regulation network. After the composition is applied to the skin (such as a corium layer), the effect of resisting skin photoaging is achieved by adjusting an AMPK signal channel. The metformin is used as an active ingredient to prepare a medicine or a medical instrument, and is beneficial to clinically anti-photoaging application of the skin.

The invention relates to an application of a curcumin-zinc organic framework compound as an active ingredient in preparation of a medical instrument for treating alopecia. Through verification, curcumin and zinc ions are prepared into an MOF structure (ZnMOFs), and the MOF structure (ZnMOFs) is encapsulated by gamma-polyglutamic acid (gamma-PGA) to prepare the soluble microneedle patch (ZnMOF-MNs) which is used for promoting hair growth under various adverse conditions. In-vitro studies find that ZnMOFs can protect DPCs from apoptosis caused by zinc deficiency and oxidative stress.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The present invention relates to a novel microneedle platform for minimally invasive delivery of therapeutic agents and the modulation of the neuro-immune axis in deep tissue. The present invention also adopts an innovative approach for minimally invasive and precisely controllable treatment of deep cutaneous diseases, conditions, and disorders using said electroconductive MN patch, which has the potential to benefit millions of patients worldwide.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

The invention discloses a vascular endothelial growth factor (VEGF) and antibacterial peptide (AMP) loaded chitosan methacrylic acid (CSMA) hydrogel microneedle patch as well as a preparation method and application thereof, the microneedle patch takes CSMA hydrogel as a main body material, the CSMA hydrogel is crosslinked and cured through ultraviolet light, and the microneedle patch has the characteristics of simplicity and convenience in preparation and stable material performance. The microneedle patch can continuously and stably release VEGF and AMP, promote wound healing and inhibit bacterial infection. Experiments show that the hydrogel microneedle is non-toxic to cells, has good biocompatibility and biodegradability, and also has excellent antibacterial performance. The invention provides an efficient and safe novel treatment tool for repairing infectious wounds.

The purpose of the present invention is to promote diffusion of an active component contained in a supplied liquid agent under a surface layer, using a compact configuration.　A diffusion promotion device (100) comprises a first cylindrical member (110) and a second cylindrical member (120). In a state in which a liquid agent has been or is being supplied to an object from a liquid agent supply unit (220) of a liquid agent supply device (200) accommodated in an internal accommodation space of the diffusion promotion device (100), when a current path is formed between a first electrode (1151 and / or 1152) formed on a side surface of the first cylindrical member (110) and a second electrode (125) formed on a tip end portion of the second cylindrical member (120) through a surface layer portion of the object, diffusion of an active component contained in the liquid agent under the surface layer of the object (for example, the surface or stratum corneum of the skin of a person) is promoted. That is, the diffusion promotion device (100) promotes diffusion of the active ingredient under the surface layer of the object by an ion introduction effect.

The invention provides a multi-sulfonic acid mucopolysaccharide (MPS)-based microneedle preparation and a preparation method thereof. The microneedle preparation is prepared from polysulfonic mucopolysaccharide, hyaluronic acid, sodium carboxymethyl cellulose, glycerol, a pH regulator and water, has excellent stability and good transdermal drug delivery performance, and is suitable for phlebitis, varicosity, scar improvement and the like.

Disclosed is an oral apparatus for injection administration in the digestive tract, comprising a housing, a trigger assembly, and an administration assembly. The housing comprises a top cover at the upper part thereof, a middle housing placed in the middle, and a base located at the bottom. The material density of the middle housing is less than the material density of the base, so that the apparatus is in the shape of a roly-poly toy. The trigger assembly comprises a soluble fixing member, an elastic member, and a transmission member. The administration assembly comprises a microneedle and a drug. The apparatus provided by the present invention, by means of an arranged liquid storage bag, greatly increases the drug loading capacity and can theoretically achieve a drug loading capacity of 50 mg, which is a significant improvement over the prior art.

The invention provides a pregabalin slow-release type dissolving microneedle patch based on PLGA microspheres as well as a preparation method and application thereof. The method comprises the following steps: dissolving pregabalin and hyaluronic acid in deionized water to form an inner water phase (W1); dissolving PLGA in dichloromethane to form an organic phase (O); performing ultrasonic emulsification on the internal water phase and the organic phase to form W / O primary emulsion; rapidly adding the primary emulsion into an external water phase (W2) containing PVA and NaCl to form a W1 / O / W2 type multiple emulsion, and then carrying out solvent evaporation curing, centrifugal washing and freeze drying to obtain PLGA (at) PG microspheres; and uniformly dispersing the PLGA (at) PG microspheres in a hyaluronic acid solution, adding into a microneedle mold, vacuumizing, centrifuging, drying, and demolding the microneedle to obtain the dissolution type microneedle patch. By optimizing microsphere preparation, drug sustained release and microneedle patch preparation technologies are realized, and an efficient, safe and continuous local delivery platform is provided.

The present invention relates to a microneedle patch for creating a tattooing image on skin wherein the microneedle patch comprises a backing layer and an array of microneedles extending from the backing layer wherein the microneedles each comprise a distal tip portion having a tattooing substance, wherein the microneedle is configured to be inserted into the skin of a subject and to release the tattooing substance in the skin, thereby creating a tattooing image visible to the human eye in the skin. Each microneedle in the array of microneedles may correspond to a point or pixel of the tattoo image or portion thereof.

The invention relates to a gingerol and shogaol loaded double-layer microneedle and a preparation method and application thereof.The double-layer microneedle comprises a microneedle base and a microneedle body, and the microneedle body is prepared from gingerol, shogaol, a base material and a medicinal solubilizer. The double-layer microneedle provided by the invention realizes simultaneous loading of gingerol and shogaol, solves the problems of poor stability and low water solubility of gingerol and shogaol, and realizes transdermal transmission of drugs. The gingerol and the enol are jointly loaded in the microneedle body of the double-layer microneedle, and the gingerol and the enol have a synergistic effect, so that the treatment effect of the microneedle on the diabetic wound surface can be further improved.

The invention relates to the technical field of hollow microneedles, in particular to a preparation method of a hollow microneedle and a mold of the hollow microneedle. The female die and the limiting plate are clamped through the positioning device, the relative positions of the female die and the limiting plate are finely adjusted, then a guide wire is used for penetrating, the hollow microneedle manufacturing die is obtained, and the die can be used for casting hollow microneedles in one step. The mold can be repeatedly used, all procedures and materials are low in price and easy to obtain, and the manufacturing cost of the hollow microneedle is greatly reduced; by changing the shape of the recess in the female die, the hollow microneedles with different shapes and different sizes can be manufactured, and the preparation of the hollow microneedles with large length-diameter ratio can be realized; the hollow microneedles with different holes can be prepared by changing the size and the shape of the guide wire; by adding different microneedle preparation solutions, the platform can be suitable for producing hollow microneedles made of different materials; in conclusion, the preparation method of the hollow microneedle has the characteristics of low cost, universality and high individuation.