564results about "Microneedles" patented technology

Disclosed is an oral apparatus for injection administration in the digestive tract, comprising a housing, a trigger assembly, and an administration assembly. The housing comprises a top cover at the upper part thereof, a middle housing placed in the middle, and a base located at the bottom. The material density of the middle housing is less than the material density of the base, so that the apparatus is in the shape of a roly-poly toy. The trigger assembly comprises a soluble fixing member, an elastic member, and a transmission member. The administration assembly comprises a microneedle and a drug. The apparatus provided by the present invention, by means of an arranged liquid storage bag, greatly increases the drug loading capacity and can theoretically achieve a drug loading capacity of 50 mg, which is a significant improvement over the prior art.

A microneedle array patch 1101 can include a plurality of microneedles 1102 including an agent that is loaded into at least a tip of the microneedles, a base structure 1102 configured to support the plurality of microneedles when force is applied against the second flat surface to insert the plurality of microneedles into skin; and an adhesive 1104 disposed around the plurality of microneedles, the adhesive configured to secure the base structure and the plurality of microneedles to the skin for a predetermined period of time. The microneedle array patches can include identifiers 1108 and / or sensors 1112 for measuring information regarding the microneedle array patches and / or retrieving information regarding the microneedle array patches.

The invention discloses a self-driven diagnosis and treatment integrated microneedle array paper-based chip as well as a preparation method and application thereof, and belongs to the technical field of biomedicine. The microneedle array chip system comprises a function integration module which at least comprises a self-powered extraction unit, a sensing detection unit and a controlled drug delivery unit. According to the microneedle array paper-based chip, biomarkers in skin interstitial fluid are efficiently collected based on a self-powered thermoelectric chemical battery microneedle, PtPB (at) PEG (at) HA nanoparticles loaded on an immunochromatography test strip combination pad are triggered to be subjected to ring opening, a hybridization chain reaction is induced to generate DNA nano-enzyme, and TMB is catalyzed to develop color; the open-loop nanoparticles can be used for SERS cross detection of biomarkers, and can be used as a thermal initiator to activate the phase change microneedle under the irradiation of near-infrared light, so that drugs are released as required, and precise treatment is realized. Besides, objective quantitative analysis of color signals is realized by constructing a convolutional neural network model, and the system has the functions of naked eye screening, intelligent quantification and personalized treatment, and can improve the home management ability of early skin cancer.

The present invention relates to a 3D printing composite hydrogel microneedle, the 3D printing composite hydrogel microneedle comprises methacrylated chitosan, o-nitrobenzyl alcohol polyethylene glycol, resveratrol and a liposome, and the resveratrol is entrapped in the liposome. The preparation method comprises the following steps: preparing resveratrol-loaded lipidosome, and preparing the 3D printing composite hydrogel microneedle. Through organic combination of the pharmacological activity of resveratrol, the controllable skeleton of PEGNB, the adhesion and antibacterial characteristics of CSMA, the precise drug delivery capability of a microneedle and the precise preparation advantage of 3D printing, the innovative microneedle patch with long-acting drug delivery, excellent biocompatibility and myocardial repair function is provided; and a new solution is provided for myocardial injury treatment.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The invention relates to a hand-held microneedling device (1; 20) for local puncturing of a skin, comprising a housing (2); a drive device which is arranged in the housing (2) and is configured to provide a drive force; a skin puncturing device (6); a microneedling puncturing tool (8) which is formed on the skin puncturing device (6) and is connected to the drive device such that, during operation, the microneedling puncturing tool (8) can be moved back and forth at a repetition rate by means of the drive force; and a needle plate (9) which is formed on the microneedling puncturing tool (8) and on which a plurality of puncturing needles (10) are arranged distributed over a front-side application surface (11); wherein, during operation, the microneedling puncturing tool (8) can be moved back and forth, between a front working position and a rear working position which is retracted in comparison thereto, by means of the drive force at the repetition rate. Furthermore, a skin puncturing device (6) for a hand-held microneedling device and an article are provided.

A microneedle array system with heterogeneous needles, designed for the enhanced transdermal delivery of bioactive agents for therapeutic and diagnostic purposes. This system includes a variety of microneedle 140 configurations, such as primary and secondary microneedles that differ in size, shape, and material to optimize delivery and functionality. Secondary needles are specifically designed with additional features such as sensors, specialized coatings, and microelectronics to perform tasks beyond simple delivery, such as in-situ detection and measurement of physiological responses, and stimulation for enhanced drug absorption and therapeutic effect.

A system includes a wearable device including a base adapted to be connected to skin of a patient. An electrochemical sensor is connected to the base. The electrochemical sensor includes a sensor medium responsive to lactate. The electrochemical sensor is in fluid connection with one or more transdermal fluid paths in connection with the base. The one or more transdermal fluid paths are configured to be placed in fluid connection with the subdermal fluid of the patient. The system further includes electronic circuitry including at least one measurement system in operative connection with the electrochemical sensor to measure a variable providing a measure of change in at least one property of the sensor medium which is dependent upon the presence of lactate in the subdermal fluid.

The application provides a radionuclide nanohydrogel microneedle and a preparation method and application thereof, and belongs to the field of nanobiomedicine. 32 P-labeled calcium phosphate, which is formed by a biomimetic reaction of Ag2S@Ca 32 P nanoparticles, and a base layer which is a base matrix and comprises hyaluronic acid 32 P nanohydrogel microneedle can release Ag2S nanoparticles in response to a weakly acidic tumor environment, and under the irradiation of near-infrared light, the photothermal conversion efficiency can effectively kill bacteria, effectively improve the tumor hypoxic environment, enhance the treatment effect of radionuclides, play an antibacterial and wound healing promoting role in melanoma defect repair, and maximize the inhibition of tumor growth and tumor recurrence.

A microneedle device comprises a device structure, insertable to a living body and being formed with an opened niche at least partially surrounded by walls of micrometric heights above a base of the niche for allowing the niche to be filled with a blood sample upon the insertion. The device also comprises a biosensor configured to sense a bioanalyte in the blood sample and having a sensing element formed on the base. The thickness of the sensing element is less than the micrometric heights of the walls.

Microneedle structure of the present invention includes a needle-shaped portion having an interior formed with a hole portion. The needle-shaped portion contains a low-melting-point resin having a weight-average molecular weight of 25,000 or more and a melting point of 130° C. or lower. Such a microneedle structure can be configured to have a needle-shaped portion having high strength.

The invention belongs to the technical field of medical instruments, and provides a painless microneedle patch loaded with low-molecular-weight heparin and a preparation method of the painless microneedle patch in order to solve the problems that most existing microneedle products aim at small-molecular drugs, lack protection and slow release design for the low-molecular-weight heparin, low drug loading efficiency, poor activity retention and incapability of adapting to long-term anticoagulation treatment. The painless micro-needle patch comprises a substrate layer and a composite micro-needle, the composite microneedle is composed of a plurality of microneedles arranged in an array and fixed on one surface of the substrate layer and a low-molecular heparin delivery material loaded in the microneedles. According to the painless microneedle patch loaded with the low-molecular heparin, efficient percutaneous delivery of drugs can be achieved, local adverse reactions are reduced, the operation process is simplified, and the long-term drug use requirements under different anticoagulation scenes are met.

A skin surgery device equipped with a needle group and a driving method thereof are disclosed. The skin surgery device equipped with a needle group, according to an embodiment of the present invention, comprises: a needle group comprising a plurality of needles; a first circuit board to which a first needle group that is a part of the needle group is fixed and in which a perforated portion is formed; and a second circuit board to which a second needle group that is the other part of the needle group is fixed, wherein the second needle group is formed to pass through and protrude out of the perforated portion of the first circuit board.

The drug delivery device includes at least one tissue-penetrating member configured to be implanted in tissue, the at least one tissue-penetrating member including a plurality of cavities and at least one payload including at least one active pharmaceutical ingredient (API), the at least one payload being loaded into the plurality of cavities such that the at least one API can be absorbed into the tissue when the at least one tissue-penetrating member is implanted in the tissue, and a ratio of a surface area of ​​the plurality of cavities to a volume of the plurality of cavities is at least 0.5:1.

The present disclosure provides microneedle devices and kits for extracting biomarkers from a tissue. The present disclosure provides methods selecting a treatment for an autoimmune disease. The present disclosure also provides methods of nucleic acid analysis to prospectively predict a patient's response to a therapeutic.

Measurements are performed on biological subjects by using microstructures to penetrate the functional barriers of the target. [Solution] A system for performing measurements on a biological object, comprising: at least one substrate 511 including a plurality of plate microstructures 512.1, 512.2 configured to penetrate the stratum corneum of the object; at least one sensor operably connected to at least one microstructure and configured to measure a response signal from at least one microstructure; and one or more electronic processing devices configured to perform at least one of the following: determine the measured response signal, provide an output based on the measured response signal, perform an analysis using at least part of the measured response signal, and store data indicating at least part of the measured response signal.

The self-current-generating skin-applied patch includes a first region that contacts the user's skin and a second region that is spaced apart from the first region and contacts the adjacent skin that the first region contacts. The first region or the second region contains a biodegradable metal that contacts the user's skin or reacts with moisture in tissue to be decomposed and absorbed. The first region or the second region is provided as a thin sheet-like structure integral with the first region that directly contacts the user's skin and has at least one penetration that allows fluid delivery from the side opposite to the skin contact; a second electrode layer made of a different material that has a different standard reduction potential from the material that makes up the first electrode layer, located on the side opposite to the skin contact of the first electrode layer while being insulated from the first electrode layer, and at least a portion of the second electrode layer extends to be electrically connected to the second region; and a carrier layer that is a thick sheet-like layer located on the side opposite to the skin contact of the first electrode layer and is made of a hydrophilic material that can carry an ionic solution. The self-generated microcurrent can provide sufficient iontophoresis of active ingredients and other microcurrent effects even without a separate power source such as a battery.

Disclosed is a microneedle patch, including: a microneedle part including a base and a plurality of needles for forming tips protruding in a sharp shape from one surface of the base; and a polymer fiber layer formed to cover the microneedle part to perform a function of protecting an active pharmaceutical ingredient contained in the needles from moisture and contaminants, wherein the edge of the polymer fiber layer is connected to the edge of one surface of the base, and a central part of the polymer fiber layer is supported in a state of being stacked and placed on tips of the needles, and the edge of the polymer fiber layer may be connected to the edge of one surface of the base, and the central part of the polymer fiber layer may be supported in a state of being stacked and placed on the tips of the needles.

Provided is a mold for manufacturing a skin attachable thin film, the mold including: a cast part having a ‘U’ shape to accommodate a mixed solution in an inner space, and including a lower surface part and a side part, and an inner space accommodating the mixed solution; and at least one protruding pillar protruding from at least a partial region of the lower surface part.

The present application relates to a kind of radiotherapy sensitization microneedle and its preparation method and application, belong to biological medicine technical field.The radiotherapy sensitization microneedle of the present application includes hyaluronic acid and nano radiosensitizer;The radiotherapy sensitization microneedle is obtained by drying after hyaluronic acid and nano radiosensitizer solution are mixed;The nano radiosensitizer solution is prepared by the following method: hafnium salt, 1,1'-ferrocene dicarboxylic acid and benzoic acid are mixed in organic solvent and stirred, centrifugal;The supernatant obtained is dialyzed, extracted, and the liquid phase obtained after solid-liquid separation is nano radiosensitizer solution.The radiotherapy sensitization microneedle of the present application is applied to the growth inhibition and radiotherapy sensitization of mouse melanoma cell B16F10 cell, can fully play the role of radiotherapy sensitization while overcoming the limitation of prior art, and preparation route is simple, and have certain conversion prospect.

The present invention provides a novel method for manufacturing a microstructure via the use of a viscous polymer, particularly microstructures that may be found on medical devices, such as transdermal patches, for either cosmetic or medicinal purposes.

This invention discloses a GLP-1 peptide drug microneedle and its preparation method. The microneedle is composed of PVP, NVP, a photoinitiator, and a GLP-1 receptor agonist. The preparation method includes two steps: material preparation and peptide microneedle patch preparation. First, a certain amount of PVP is dissolved in NVP to prepare a solution with appropriate specific gravity and viscosity. Then, the photoinitiator and GLP-1 receptor agonist are added to the solution to form a liquid system that is as uniformly suspended as possible. Second, the suspension is filled into a microneedle mold, and NVP is polymerized into solid PVP by ultraviolet light irradiation. Under the constraint of the mold, the solid PVP forms the geometric shape of the microneedle. Subsequently, a small amount of NVP is spread evenly on the backing layer of the microneedle and covered with a plastic film. Ultraviolet light irradiation is applied again to crosslink the plastic film with the PVP microneedle, and the microneedle is then peeled out of the mold. The advantage of this application is that it uses PVP to prepare an NVP solution with suitable specific gravity and viscosity, so that the subsequently added drug is uniformly suspended in the solution, thereby improving the uniformity of drug loading on microneedles and increasing the drug loading capacity, which is beneficial to improving the efficacy and consistency of drug efficacy.

The invention discloses a needle head assembly for a skin operation. The needle head assembly comprises at least one needle head, an adjusting cap, a needle seat cap and a needle head fixing part. The device can be combined with an injection device, and a large-area injection operation is carried out on the skin subcutaneous tissue through a plurality of needles; after the exposed length of the needle head is adjusted, the needle head can be fixed to prevent idling in an operation process; by adjusting the length of the needle head, the needle head can be accurately inserted into subcutaneous tissue with the target operation depth for operation, and the operation accuracy is improved. In addition, medicine leaked in the operation process can smoothly flow into the inner space of the needle head assembly, the discomfort of a patient caused by medicine outflow is avoided, and the operation convenience is improved.

The present application relates to the technical field of microneedle transdermal drug delivery, and particularly relates to a transdermal drug delivery patch and a penetration promoting patch assembly. The transdermal drug delivery patch comprises a driving device, the driving device comprises an elastic air bag, a pressure generating unit and a pressure limiting valve, the pressure generating unit is connected with the elastic air bag, is used for increasing the internal air pressure of the elastic air bag and making the elastic air bag expand, the pressure limiting valve is arranged on the elastic air bag, and is opened only when the air pressure in the elastic air bag exceeds a threshold value, is used for reducing the internal air pressure of the elastic air bag and making the elastic air bag shrink; the patch further comprises a dredging device, the dredging device comprises a substrate, one side surface of the substrate is in contact with the elastic air bag, and a dredging unit capable of treating the skin is arranged on the other side surface of the substrate; the dredging unit can repeatedly touch the skin in the process that the elastic air bag repeatedly expands and shrinks. The present application can effectively improve the absorption effect of the skin on active ingredients, and simultaneously reduce the operation and learning difficulty.

A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release a first shell portion and a second shell portion of the capsule from one another in response to stimuli or conditions in or en route to the duodenum or other target location. The launcher can drive the released first shell portion and the second shell portion away from one another to expose the array of microneedles in a position for achieving penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

An applicator includes a holder 22 configured to hold a microneedle base on which a microneedle array is provided, a pusher 21 for pushing the holder 22 toward skin, and a shell 23 that includes a first part to contact with the skin and a second part configured to hold the holder 22, the shell 23 being deformable while maintaining an orientation of the microneedle base by connecting the first part and the second part.

Wearable medical devices having a plurality of microneedles on a first rotationally-distinct segment and a plurality of microneedles on a second rotationally-distinct segment are described. The wearable medical devices are dry electrodes for direct attachment to skin. Methods of attaching wearable medical devices to the skin and using said devices to monitor biological signals are also described.

To provide microneedles and microneedle devices comprising silk fibroin-based microneedle tips for sustained dermal delivery of anti-cancer agents and / or immunomodulatory agents, and methods of making and using the same.SOLUTION: A microneedle device (e.g., a microneedle patch) comprising a plurality of silk fibroin-based microneedles, wherein the plurality of microneedles comprises a first microneedle comprising an anti-cancer agent; and a second microneedle comprising an immunomodulatory agent, wherein the first and / or second microneedle comprises silk fibroin (e.g., regenerated silk fibroin and / or recombinant silk fibroin), and wherein the microneedle device is configured to deliver the anti-cancer agent and the immunomodulatory agent to a subject.SELECTED DRAWING: Figure 1

A microneedle patch applicator device (1) comprises a plunger (2) having a distal microneedle patch abutting surface (19) and a receiver (3) for the plunger. The plunger is configured for reciprocal linear movement relative to the receiver between an extended configuration in which the distal microneedle patch abutting surface is spaced from the receiver and a depressed configuration. The receiver comprises a force limiter associated with the plunger configured to prevent movement of the plunger from the extended configuration to the depressed configuration until a pre-determined threshold input force has been applied to the plunger by the user.