1671results about "Microneedles" patented technology

Set forth are vascular valves and servovalves and methods of using the same that may be positioned in the circulatory system without interrupting blood flow to facilitate solid organ transplantation so as to reduce graft organ anoxia and degradation before and after harvesting and storage, thereby minimizing late-term cardiac allograft vasculopathy as a major cause of graft failure. Along the urinary tract, bypassing bladder-generated urge sensation by diverting urine directly from the ureters to a neobladder or collection bag alleviates intractable incontinence, nocturia, urethral syndrome, overactive bladder, dysuria, or frequency. Where the lower tract is missing, a prosthesis can thwart disease and preclude the degenerative metaplastic transition to carcinoma risked when gut is used to construct a conduit for urine, a neobladder, and / or high-maintenance stoma. Druglines to valves and servovalves can directly pipeline-target medication to nidi, anastomoses, or any other trouble spots.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

The invention relates to a layered drug-loading microneedle patch as well as a preparation method and application thereof. The preparation method of the layered drug-loading microneedle patch comprises the following steps: S1, dissolving a drug and a soluble high-molecular polymer in a solvent according to a mass ratio of (2: 1)-(1: 12) to form a needle tip solution, then filling a needle tip cavity of a microneedle mold with the needle tip solution, drying, and removing redundant drug residues on the surface to form a drug-loading needle tip layer; and S2, filling a mold containing the drug-loading needle tip layer with a photocurable polymer, performing ultraviolet curing for 10-30 seconds under the wavelength of 365-405 nm, and then performing demolding to form a substrate layer, thereby obtaining the layered drug-loading microneedle patch. According to the method, one-time filling of the needle tip part is successfully achieved by combining needle tip auxiliary material proportion optimization, meanwhile, the curing process is rapid, the medicine utilization rate and the process stability are remarkably improved, the medicine stability is good, and the method is suitable for industrial production.

The invention relates to an injection device (100) with needle for injecting a product, in particular a cosmetic product, the device comprising: a suction chamber (1), a support surface (4) inside the chamber (1) at a position set back from the opening (2), and a suction source, the support surface (4) comprising at least one microneedle (6) for carrying out the injection, the suction opening (2) is closed by an intermediate component (7), defining a contact surface with the target area (3), and having at least one orifice (8) designed to be passed through by the microneedle (6), when the target area (3) is suctioned towards the chamber (1).

Provided is a needle roller device for skin injection which includes a main body comprising, formed on one side thereof, an injection pipe part with an injection port to which a drug injection device is detachably coupled, and formed on the other side thereof, an expansion part with predetermined width and length communicating with the injection pipe part, a roller part rotatably coupled to the expansion part, and comprising a plurality of needle protrusions formed on an outer circumferential surface, and fine needles coupled to the plurality of needle protrusions and exposed to outside, and a rotation connection part that fastens the main body and the roller part.

Apparatus comprising a housing, at least one needle arranged for reciprocal motion between a retracted position and an extended position to penetrate an animal tissue surface when in the extended position, and a sealing device defining a channel through which a movable shaft extends to move the at least one needle in the reciprocating motion, wherein the sealing device serves to form a seal between the housing and the movable shaft. A corresponding method of preventing cross-contamination within apparatus for minimally invasive treatment of skin is also disclosed.

The invention relates to the technical field of transdermal drug delivery, in particular to a drug-loaded microneedle, a drug-loaded microneedle patch and an electrically controlled drug release microneedle system.The drug-loaded microneedle comprises a needle body, a drug component and an electric sealing material, the needle body has biocompatibility and conductivity and is a hydrogel microneedle or a porous microneedle, and the drug component is attached to the drug-loaded microneedle patch. The medicine components are doped in the needle body or coated on the outer surface of the needle body. The electric sealing material is doped in the needle body and / or wraps the surface of the needle body, and the electric sealing material is connected with the needle body through at least one of covalent bonds, ionic bonds and coordinate bonds. When the drug-loaded microneedle is inserted into a target tissue, controlled release of drug components can be achieved through an electrical stimulation signal, and active components are guided into the target tissue through electric drive. According to the invention, the ion exchange behavior of the material is controlled through the electric field, so that the opening and closing of a drug release channel are realized, the purpose of electric switching chemical sealing is achieved, reversible control is realized by adjusting the intensity and direction of the electric field, and the accurate opening and closing of drug release are realized.

The invention provides an intelligent collaborative robot system for microneedle introduction, and relates to the technical field of medical puncture. The skin cuticle thickness, the surface roughness, the hue and other characteristic parameters are obtained through optical scanning and image processing technologies, and the initial puncture depth and the initial puncture frequency are predicted through a deep learning model; in the puncture process, skin humidity, impedance, tissue density and hue changes are monitored in real time, and a depth adjustment index and a frequency adjustment index are generated to adjust the initial puncture depth and the initial puncture frequency. According to the method, real-time sensing of the skin state and accurate regulation and control of puncture parameters are achieved, and the safety of microneedle treatment is remarkably improved.

An applicator for treating acne including one or more microneedles, an optical sensor configured to detect acne, a removal system including a suction mechanism configured to remove acne material, and a chamber for containing the acne material, a remedy system configured apply one or more acne remedies, a light source configured to apply a light therapy to skin, and a processor configured to detect acne at one or more affected areas on skin, and direct the applicator to apply treatment, where the treatment includes penetrating the skin at the one or more affected areas with the one or more microneedles, removing acne material with suction mechanism, applying the light therapy to the one or more affected areas, and applying one or more acne remedies to the one or more affected areas.

The invention relates to an application of metformin in preparation of skin anti-photoaging drugs or medical instruments. Through verification, the metformin has the effects of promoting the formation of autophagosome, recovering the patency of autophagy flow and remodeling an autophagy-ECM metabolism regulation network. After the composition is applied to the skin (such as a corium layer), the effect of resisting skin photoaging is achieved by adjusting an AMPK signal channel. The metformin is used as an active ingredient to prepare a medicine or a medical instrument, and is beneficial to clinically anti-photoaging application of the skin.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The present invention relates to a novel microneedle platform for minimally invasive delivery of therapeutic agents and the modulation of the neuro-immune axis in deep tissue. The present invention also adopts an innovative approach for minimally invasive and precisely controllable treatment of deep cutaneous diseases, conditions, and disorders using said electroconductive MN patch, which has the potential to benefit millions of patients worldwide.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

The invention discloses a vascular endothelial growth factor (VEGF) and antibacterial peptide (AMP) loaded chitosan methacrylic acid (CSMA) hydrogel microneedle patch as well as a preparation method and application thereof, the microneedle patch takes CSMA hydrogel as a main body material, the CSMA hydrogel is crosslinked and cured through ultraviolet light, and the microneedle patch has the characteristics of simplicity and convenience in preparation and stable material performance. The microneedle patch can continuously and stably release VEGF and AMP, promote wound healing and inhibit bacterial infection. Experiments show that the hydrogel microneedle is non-toxic to cells, has good biocompatibility and biodegradability, and also has excellent antibacterial performance. The invention provides an efficient and safe novel treatment tool for repairing infectious wounds.

The purpose of the present invention is to promote diffusion of an active component contained in a supplied liquid agent under a surface layer, using a compact configuration.　A diffusion promotion device (100) comprises a first cylindrical member (110) and a second cylindrical member (120). In a state in which a liquid agent has been or is being supplied to an object from a liquid agent supply unit (220) of a liquid agent supply device (200) accommodated in an internal accommodation space of the diffusion promotion device (100), when a current path is formed between a first electrode (1151 and / or 1152) formed on a side surface of the first cylindrical member (110) and a second electrode (125) formed on a tip end portion of the second cylindrical member (120) through a surface layer portion of the object, diffusion of an active component contained in the liquid agent under the surface layer of the object (for example, the surface or stratum corneum of the skin of a person) is promoted. That is, the diffusion promotion device (100) promotes diffusion of the active ingredient under the surface layer of the object by an ion introduction effect.

The invention provides a multi-sulfonic acid mucopolysaccharide (MPS)-based microneedle preparation and a preparation method thereof. The microneedle preparation is prepared from polysulfonic mucopolysaccharide, hyaluronic acid, sodium carboxymethyl cellulose, glycerol, a pH regulator and water, has excellent stability and good transdermal drug delivery performance, and is suitable for phlebitis, varicosity, scar improvement and the like.

Disclosed is an oral apparatus for injection administration in the digestive tract, comprising a housing, a trigger assembly, and an administration assembly. The housing comprises a top cover at the upper part thereof, a middle housing placed in the middle, and a base located at the bottom. The material density of the middle housing is less than the material density of the base, so that the apparatus is in the shape of a roly-poly toy. The trigger assembly comprises a soluble fixing member, an elastic member, and a transmission member. The administration assembly comprises a microneedle and a drug. The apparatus provided by the present invention, by means of an arranged liquid storage bag, greatly increases the drug loading capacity and can theoretically achieve a drug loading capacity of 50 mg, which is a significant improvement over the prior art.

The invention provides a pregabalin slow-release type dissolving microneedle patch based on PLGA microspheres as well as a preparation method and application thereof. The method comprises the following steps: dissolving pregabalin and hyaluronic acid in deionized water to form an inner water phase (W1); dissolving PLGA in dichloromethane to form an organic phase (O); performing ultrasonic emulsification on the internal water phase and the organic phase to form W / O primary emulsion; rapidly adding the primary emulsion into an external water phase (W2) containing PVA and NaCl to form a W1 / O / W2 type multiple emulsion, and then carrying out solvent evaporation curing, centrifugal washing and freeze drying to obtain PLGA (at) PG microspheres; and uniformly dispersing the PLGA (at) PG microspheres in a hyaluronic acid solution, adding into a microneedle mold, vacuumizing, centrifuging, drying, and demolding the microneedle to obtain the dissolution type microneedle patch. By optimizing microsphere preparation, drug sustained release and microneedle patch preparation technologies are realized, and an efficient, safe and continuous local delivery platform is provided.

The invention relates to a gingerol and shogaol loaded double-layer microneedle and a preparation method and application thereof.The double-layer microneedle comprises a microneedle base and a microneedle body, and the microneedle body is prepared from gingerol, shogaol, a base material and a medicinal solubilizer. The double-layer microneedle provided by the invention realizes simultaneous loading of gingerol and shogaol, solves the problems of poor stability and low water solubility of gingerol and shogaol, and realizes transdermal transmission of drugs. The gingerol and the enol are jointly loaded in the microneedle body of the double-layer microneedle, and the gingerol and the enol have a synergistic effect, so that the treatment effect of the microneedle on the diabetic wound surface can be further improved.

The invention provides a hydrogel microneedle patch for treating oral ulcer and a preparation method, and belongs to the technical field of biomedical engineering. The technical problems that in the traditional oral ulcer administration process, medicine is difficult to retain at the focus for a long time, is easily scoured by saliva and is influenced by tongue and cheek movement are solved. According to the technical scheme, the method comprises the following steps: 1) designing and preparing a microneedle patch mold; (2) synthesizing drug-loaded polydopamine nano particles; (3) preparing a microneedle patch; and 4) evaluating the performance of the microneedle patch. The invention has the following beneficial effects: on one hand, the combination of the drug-loaded nanoparticles and the hydrogel microneedle array can reduce the dosage through drug sustained release; and on the other hand, the problems of high drug instability, low targeting property, poor bioavailability and hindering treatment effect are effectively solved, and the preparation can be widely applied to the fields of drug sustained release, wound healing, tissue engineering and the like.

The invention provides a microneedle preparation for co-delivering photo-thermal nano-enzyme and elemene as well as a preparation method and application of the microneedle preparation. The preparation method comprises the following steps: firstly, preparing a novel photo-thermal nano enzyme Au (at) MoS2 through a two-step water phase synthesis strategy; benefited from the synergistic effect of the hybrid material, the nano-enzyme shows significantly enhanced near-infrared (NIR) photothermal effect, peroxidase-like (POD) activity and glutathione-like peroxidase (GSHOx) activity, and can effectively remodel the tumor microenvironment and destroy the redox steady state. Furthermore, photo-thermal nano enzyme, beta-ELE and hyaluronic acid are used as raw materials, and a novel soluble microneedle preparation is successfully prepared through a template method. The novel composite microneedle is in a sharp rectangular pyramid shape, growth of melanoma can be effectively inhibited through percutaneous delivery of photo-thermal nano-enzyme and beta-ELE, remarkable systemic toxicity is avoided, and an innovative strategy is provided for non-invasive, efficient and safe melanoma combined treatment.

The invention discloses a bionic microneedle continuous hair transplanting system which comprises a shell extending in the axial direction, a power head axially moving relative to the shell is arranged at one end of the shell, a hair follicle supply channel penetrating front and back in the axial direction is formed in the power head, and a double-lead-screw composite seat and a motor controlling the double-lead-screw composite seat to rotate are arranged in the shell. The double-screw composite seat comprises a seat body, one end of the seat body is provided with a first screw and a second screw with unequal screw pitches, the first screw is in threaded connection with a first screw nut, the second screw is in threaded connection with a second screw nut, the second screw nut is connected with the power head, the first screw nut is provided with an ejector rod extending into the hair follicle supply channel, and the ejector rod is connected with the power head. The power head is provided with a hollow planting needle which is through front and back, and the rear end of the hollow planting needle is connected with the front end of the hair follicle supply channel. The microneedle of the system adopts a bionic structure design of venomous snake teeth and bee stinging needles, so that the puncture force and the pain of a patient are effectively reduced, the overall function is complete, and the practicability is high.

The disclosed methods relate to forming microneedle arrays from a production mold that comprises a flexible mold material. The disclosed methods can be used to reproducibly manufacture undercut dissolvable and coated microneedle arrays with various shapes and structures.

The invention relates to the technical field of medical instruments, in particular to a portable leading-in instrument which comprises a shell, a sleeve and a protruding block are arranged on the upper side of the shell in a matched mode, a butt-joint sleeve is coaxially, correspondingly and detachably fixed to the top of the sleeve, a reciprocating rod is slidably connected into the butt-joint sleeve, and a disc block is coaxially fixed to one end of the reciprocating rod. A plurality of micro needle tubes are arranged at the end, away from the reciprocating rod, of the disc block, a liquid storage structure used for supplying liquid to the micro needle tubes is arranged at the other end of the reciprocating rod, a driving structure used for driving the reciprocating rod to reciprocate is arranged in the sleeve, and an air blowing drying structure is further arranged on the shell. According to the device, the effect of guiding liquid medicine into the skin after skin breaking can be achieved, the accurate and uniform liquid medicine guiding effect is achieved, meanwhile, air blowing and skin drying operation can be conducted on the skin with many skin hairs, and the whole device is convenient to operate and convenient to carry.

The invention provides a composite nanoparticle with active substance sequential release capability, a multifunctional microneedle patch based on curcumin-loaded ZIF-67 nanoparticles, preparation methods of the composite nanoparticle and the multifunctional microneedle patch and application of the multifunctional microneedle patch, and belongs to the technical field of biology. The composite nano-particles with the active substance sequential release capability are CurZIF-67NPs, the average particle size is 403 + / -7 nm, the microstructure is dodecahedral structure particles with rough textures on the surface, and the composite nano-particles have the effects of slowly releasing bioactive substances, improving the inflammatory microenvironment and regulating and controlling osteogenesis under certain conditions. The composite nano-particle comprises curcumin powder and a ZIF-67 nano-material, the ZIF-67 nano-material can be decomposed to quickly release Co < 2 + >, macrophages are regulated and controlled to be polarized to an M2 type, and excessive immune inflammation reaction is improved; the curcumin powder is slowly released, so that the periodontal ligament stem cells can be regulated and controlled to be differentiated into osteoblasts, and the osteogenic activity is enhanced.

The invention discloses a method for preparing a transdermal microneedle based on gallium-based liquid metal, which comprises the following steps: (1) heating the gallium-based liquid metal at a temperature higher than the melting point of the liquid metal, so that the gallium-based liquid metal is completely molten into a liquid state; (2) sucking the liquid metal preheated in the step (1) by using a microsyringe or a pipettor, and quickly injecting the liquid metal into a microneedle mold, so that the liquid metal is spread and completely covers a cavity of a needle tip in the mold; (3) transferring the mold in the step (2) into a constant-temperature vacuum box, and decompressing and degassing under vacuum; in the degassing process, the degassing temperature enables the liquid metal to be kept in a flowing liquid state all the time, and vacuumizing is conducted till the pressure is not higher than 10 Pa; the degassing time is not less than 5 hours; (4) continuously injecting the preheated gallium-based liquid metal or a degradable polymer solution into the mold to form a substrate of the microneedle; and (5) transferring the mold in the step (4) to a temperature far lower than the melting point of the liquid metal, and freezing and forming to obtain the transdermal microneedle.

The composition is of a network structure and is composed of strontium ions and chlorogenic acid, and the weight ratio of the strontium ions to the chlorogenic acid is 1: (9-11). The composition and hydrogel are mixed to prepare a microneedle patch, and the microneedle patch is prepared into a medical instrument for wound repair. Through verification, the SrC-MPNs is continuously released by the SrC-MPNs (at) MN-PP, so that the substances are dissolved and absorbed into tissue fluid around a wound, and strontium ions and chlorogenic acid in the SrC-MPN can stably and continuously exert the effects of resisting bacteria and oxidation, promoting angiogenesis, promoting wound healing and the like. An in-vivo experiment result shows that the SrC-MPNs (at) MN-PP can promote in-vivo and in-vitro wound healing, promote M2 macrophage polarization, remove excessive ROS and promote angiogenesis and tissue regeneration so as to promote healing of diabetic wounds.