1193results about "Microneedles" patented technology

The invention relates to a layered drug-loading microneedle patch as well as a preparation method and application thereof. The preparation method of the layered drug-loading microneedle patch comprises the following steps: S1, dissolving a drug and a soluble high-molecular polymer in a solvent according to a mass ratio of (2: 1)-(1: 12) to form a needle tip solution, then filling a needle tip cavity of a microneedle mold with the needle tip solution, drying, and removing redundant drug residues on the surface to form a drug-loading needle tip layer; and S2, filling a mold containing the drug-loading needle tip layer with a photocurable polymer, performing ultraviolet curing for 10-30 seconds under the wavelength of 365-405 nm, and then performing demolding to form a substrate layer, thereby obtaining the layered drug-loading microneedle patch. According to the method, one-time filling of the needle tip part is successfully achieved by combining needle tip auxiliary material proportion optimization, meanwhile, the curing process is rapid, the medicine utilization rate and the process stability are remarkably improved, the medicine stability is good, and the method is suitable for industrial production.

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

Disclosed is an oral apparatus for injection administration in the digestive tract, comprising a housing, a trigger assembly, and an administration assembly. The housing comprises a top cover at the upper part thereof, a middle housing placed in the middle, and a base located at the bottom. The material density of the middle housing is less than the material density of the base, so that the apparatus is in the shape of a roly-poly toy. The trigger assembly comprises a soluble fixing member, an elastic member, and a transmission member. The administration assembly comprises a microneedle and a drug. The apparatus provided by the present invention, by means of an arranged liquid storage bag, greatly increases the drug loading capacity and can theoretically achieve a drug loading capacity of 50 mg, which is a significant improvement over the prior art.

The invention relates to the technical field of medical instruments, in particular to a portable leading-in instrument which comprises a shell, a sleeve and a protruding block are arranged on the upper side of the shell in a matched mode, a butt-joint sleeve is coaxially, correspondingly and detachably fixed to the top of the sleeve, a reciprocating rod is slidably connected into the butt-joint sleeve, and a disc block is coaxially fixed to one end of the reciprocating rod. A plurality of micro needle tubes are arranged at the end, away from the reciprocating rod, of the disc block, a liquid storage structure used for supplying liquid to the micro needle tubes is arranged at the other end of the reciprocating rod, a driving structure used for driving the reciprocating rod to reciprocate is arranged in the sleeve, and an air blowing drying structure is further arranged on the shell. According to the device, the effect of guiding liquid medicine into the skin after skin breaking can be achieved, the accurate and uniform liquid medicine guiding effect is achieved, meanwhile, air blowing and skin drying operation can be conducted on the skin with many skin hairs, and the whole device is convenient to operate and convenient to carry.

The invention discloses a multi-mode closed-loop feedback thumbtack needle electrical stimulation anti-depression system, belongs to the technical field of drug delivery systems, and particularly relates to collaborative treatment of acupoint stimulation and drug sustained release. The problems that in the prior art, cooperation of acupoint stimulation and medicine slow release cannot be achieved, and further improvement of the treatment effect is limited are solved. The system comprises an AI regulation and control module and a collaborative treatment module. The AI regulation and control module predicts treatment parameters; and the collaborative treatment module is used for carrying out collaborative treatment of acupoint electrical stimulation and skin administration on the patient based on the predicted treatment parameters. The multi-mode closed-loop feedback thumbtack needle electrical stimulation anti-depression system is suitable for collaborative treatment of acupoint stimulation and drug sustained release.

The microneedle assembly of the present invention includes: a main body (110) opened at one side thereof and including a solution reservoir (111) formed in the opened side thereof; a dispensing unit (120) disposed at the other side of the main body (110) in such a manner as to fluidically communicate with the solution reservoir (111); a needle supports (130) positioned at a front portion of each of the dispensing units (120), and protrudingly formed at the other end of the main body (110); a microneedles (140) engaged with the front end of the needle support (130); and a first solution release flow channel (150) formed to penetrate through a portion extending outwardly from a front end of the dispensing unit (120) to the front end of the needle support (130).

Various example of the present disclosure provide sensing apparatuses configured for wearable and wireless use for deep tissue physiological monitoring. The sensing apparatuses may be embodied by a thin flexible patch configured to conform with a skin surface of a subject. A sensing apparatus may include a plurality of microneedles oriented to extend towards and penetrate into the subject to a shallow depth. The microneedles may be configured as waveguides for a given sensing modality (e.g., light, ultrasound), such that sensing wave signals propagate to deep tissues. For the sensing, the sensing apparatus includes waveform generators (e.g., light-emitted diodes) and waveform detectors (e.g., photodiodes). Machine learning models may be used to process and denoise sampled data from the waveform detectors and to generate accurate and reliable physiological measurements, including heart rate, respiratory rate, pulse intensity, respiratory intensity, blood oximetry, tissue oximetry, blood flow rate, and / or the like.

A microneedle patch base layer lamination and separation device and a control method therefor, a microneedle patch base layer lamination device and a control method therefor, and a microneedle patch demolding and separation device and a control method therefor are provided. The microneedle patch base layer lamination and separation device includes a rack, a movement control mechanism, a movable seat, and a lamination and separation apparatus. The lamination and separation apparatus is arranged on the movable seat, a carrier is supported on the rack, and the movement control mechanism may control the movable seat and / or the carrier to move in a vertical direction and a horizontal direction; the lamination and separation apparatus includes a rotation control mechanism, a rotary table, an elastic pressing head, and an elastic vacuum suction cup.

The invention discloses a symmetric nucleoside microneedle patch loaded with polymer vesicles as well as a preparation method and application of the symmetric nucleoside microneedle patch. The symmetric nucleoside microneedle patch loaded with the polymer vesicles comprises a guanosine-quadruplex hydrogel microneedle tip doped with drug-loading polymer vesicles, the raw material of the drug-loaded polymer vesicle comprises a polycaprolactone-polyglutamic acid copolymer; the guanosine-quadruplex hydrogel is prepared from the following raw materials: guanosine and KB (OH) 4. The microneedle patch is constructed on the basis of dynamic covalent bond and non-covalent interaction, has a sharp tip array capable of penetrating the epithelium and the lower layer of a mucous membrane, can efficiently deliver a drug to a canker lesion part by bypassing a mucous membrane barrier, can be controllably broken under a high ROS condition of an inflammation microenvironment, has the characteristics of high drug delivery efficiency and high accuracy, and can be used for preparing a medicine for treating the canker lesion part. The effect of effectively improving chemotherapy-induced oral ulceration can be achieved by reducing inflammatory response, relieving pain feeling and inhibiting pain sensitization.

A microneedle array patch 1101 can include a plurality of microneedles 1102 including an agent that is loaded into at least a tip of the microneedles, a base structure 1102 configured to support the plurality of microneedles when force is applied against the second flat surface to insert the plurality of microneedles into skin; and an adhesive 1104 disposed around the plurality of microneedles, the adhesive configured to secure the base structure and the plurality of microneedles to the skin for a predetermined period of time. The microneedle array patches can include identifiers 1108 and / or sensors 1112 for measuring information regarding the microneedle array patches and / or retrieving information regarding the microneedle array patches.

The invention discloses a 3D bio-printing sustained-release microneedle patch used after brain glioma surgery and a preparation method thereof.The microneedle patch is prepared by compounding GFD nano-enzyme and a hydrogel base material, the GFD nano-enzyme is gambogic acid-iron-adriamycin nano-enzyme, and the hydrogel base material is a hydrogel base material. The hydrogel base material is composed of photo-crosslinking gelatin (GelMA), methacrylic hyaluronic acid (HAMA), a photoinitiator and an ultraviolet absorbent, the microneedle patch is of a conical microneedle array structure, the interior of the microneedle patch is of a porous structure, and GFD nano-enzyme is evenly distributed in microneedles. The application potential of the existing 3D biological printing and nano-enzyme technology and the technical advantages of 3D biological printing are adopted, by means of the 3D biological printing technology with high-dimensional manufacturing precision, the microneedle array structure is designed and printed in a customized mode according to the irregular shape of the tumor residual cavity of a patient, complete attachment to the wall of the residual cavity is achieved, and the dead cavity effect is solved; meanwhile, the technology can accurately regulate and control the shape, the size and the drug loading capacity of the microneedle, and provides possibility for personalized treatment.

The invention provides an intelligent compression device and method for maintaining the internal fistula function of a hemodialysis patient, and belongs to the technical field of intelligent compression. The device comprises a CMUT ultrasonic array, an errhysis sensor, a bioelectricity monitoring module, an infrared temperature sensing array, an AI intelligent decision module, a dynamic pressure adjusting system, an energy field intervention module and a microneedle drug delivery module. Through space-time alignment collection of multi-modal data, dynamic parameter optimization of an AI model and rapid cooperative response of an actuator, the internal fistula compression is spanned from experience dependence to accurate intelligence, and the hemostasis efficiency and the blood vessel protection effect are remarkably improved.

The invention discloses a self-driven diagnosis and treatment integrated microneedle array paper-based chip as well as a preparation method and application thereof, and belongs to the technical field of biomedicine. The microneedle array chip system comprises a function integration module which at least comprises a self-powered extraction unit, a sensing detection unit and a controlled drug delivery unit. According to the microneedle array paper-based chip, biomarkers in skin interstitial fluid are efficiently collected based on a self-powered thermoelectric chemical battery microneedle, PtPB (at) PEG (at) HA nanoparticles loaded on an immunochromatography test strip combination pad are triggered to be subjected to ring opening, a hybridization chain reaction is induced to generate DNA nano-enzyme, and TMB is catalyzed to develop color; the open-loop nanoparticles can be used for SERS cross detection of biomarkers, and can be used as a thermal initiator to activate the phase change microneedle under the irradiation of near-infrared light, so that drugs are released as required, and precise treatment is realized. Besides, objective quantitative analysis of color signals is realized by constructing a convolutional neural network model, and the system has the functions of naked eye screening, intelligent quantification and personalized treatment, and can improve the home management ability of early skin cancer.

The invention provides an enhanced transdermal delivery beauty patch containing efficient active PDRN (DNA sodium) and a preparation method thereof, the enhanced transdermal delivery beauty patch is composed of a needle body layer and a backing layer, the needle body layer comprises the following components by mass: 5-15% of PDRN with a molecular weight of 50-300 kDa, 10-20% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight The content of the zwitterionic polymer carrier is 30%-50%, and the zwitterionic polymer carrier is formed by copolymerizing methacryloylethyl sulfobetaine and hyaluronic acid. The composition has the characteristics of good mechanical properties, rapid dissolution, high activity retention and efficient permeation promotion, can be used for treatment of pigmentation after acne and skin barrier repair, and comprehensively improves the skin repair effect and practicability.

The invention discloses a frozen gel microneedle as well as a preparation method and application thereof, the preparation method comprises the following steps: (1) adding PBS (Phosphate Buffer Solution) into a brown bottle filled with an initiator LAP, and heating and stirring in a water bath at 40-50 DEG C for 15 minutes to obtain an initiator standard solution; (2) adding the initiator standard solution obtained in the step (1) into a brown glass bottle with HAMA, and stirring at room temperature in a dark place for 1 hour to obtain a photo-crosslinked HAMA hydrogel solution; (3) preparing a complete porous gel microneedle mold needle tip loaded with a gene therapy vector; (5) preparing a microneedle mold substrate; (6) freezing the microneedle mold with the formed needle tip and substrate to obtain a frozen gel microneedle array; and (7) demolding the frozen gel microneedle array to obtain the frozen gel microneedle. The obtained microneedle can be used for long-term collaborative treatment of chronic inflammatory diseases through percutaneous delivery of anti-inflammatory genes coded by CeNPs and rAAV2.

The present invention relates to a 3D printing composite hydrogel microneedle, the 3D printing composite hydrogel microneedle comprises methacrylated chitosan, o-nitrobenzyl alcohol polyethylene glycol, resveratrol and a liposome, and the resveratrol is entrapped in the liposome. The preparation method comprises the following steps: preparing resveratrol-loaded lipidosome, and preparing the 3D printing composite hydrogel microneedle. Through organic combination of the pharmacological activity of resveratrol, the controllable skeleton of PEGNB, the adhesion and antibacterial characteristics of CSMA, the precise drug delivery capability of a microneedle and the precise preparation advantage of 3D printing, the innovative microneedle patch with long-acting drug delivery, excellent biocompatibility and myocardial repair function is provided; and a new solution is provided for myocardial injury treatment.

Disclosed herein are hydrogels that can be loaded with myogenic agents, for instance muscle stem cells (MuSCs) / satellite cells, pro-myogenic factors, and combinations thereof. The hydrogels can be contacted with damaged muscle tissue, thereby facilitating muscle growth and repair. Further provided are methods of repairing muscle tissue in a patient in need thereof, said methods comprising contacting the muscle tissue with a composition comprising the hydrogel. Also provided herein are kits comprising the hydrogel composition and a substrate comprising at least one microneedle.

The invention relates to a self-cascade photo-thermal response core-shell microneedle patch as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. A self-cascade photo-thermal response core-shell microneedle patch comprises a backing layer and a microneedle array arranged on the backing layer, the microneedle array is composed of a plurality of microneedles with core-shell structures, each core-shell microneedle comprises a photo-thermal response phase change shell and a soluble inner core, and the shells are filled with the soluble inner cores. The invention also provides a core-shell microneedle-hydrogel patch group, which comprises the core-shell microneedle patch and the hydrogel patch. The core-shell microneedle patch provided by the invention can realize controllable release of drugs, and a combined treatment platform is formed through an anti-oxidation-oxygen production-anti-inflammatory multi-target collaborative strategy. The patch group provided by the invention has temperature responsiveness, reversible adhesion and skin moistening and moisturizing effects, and can realize rapid adhesion and painless stripping.

The present invention relates to the technical field of medicine. More specifically, the present invention relates to a microneedle composition containing an active component, and a preparation method therefor and the use thereof. The microneedle composition containing an active component contains an active component, a biodegradable polymer material, a surfactant, and the balance of a solvent, wherein on the basis of the total weight of the microneedle composition, the weight percentage of the active component is 1-15%, the weight percentage of the biodegradable polymer material is 0.1-15%, and the weight percentage of the surfactant is 0.05-5%.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The invention relates to a hand-held microneedling device (1; 20) for local puncturing of a skin, comprising a housing (2); a drive device which is arranged in the housing (2) and is configured to provide a drive force; a skin puncturing device (6); a microneedling puncturing tool (8) which is formed on the skin puncturing device (6) and is connected to the drive device such that, during operation, the microneedling puncturing tool (8) can be moved back and forth at a repetition rate by means of the drive force; and a needle plate (9) which is formed on the microneedling puncturing tool (8) and on which a plurality of puncturing needles (10) are arranged distributed over a front-side application surface (11); wherein, during operation, the microneedling puncturing tool (8) can be moved back and forth, between a front working position and a rear working position which is retracted in comparison thereto, by means of the drive force at the repetition rate. Furthermore, a skin puncturing device (6) for a hand-held microneedling device and an article are provided.

The invention discloses a pH response hydrogel microneedle, which comprises a microneedle substrate, microneedle tips are arranged on the microneedle substrate, the height of the microneedle tips is 100-1600 microns, the diameter of the tip ends of the microneedle tips is 5-15 microns, and the density of the microneedle tips is 200-1000 pieces per square centimeter. The preparation method comprises the following steps: preparing a hyaluronic acid solution for the microneedle substrate, preparing a methacrylated chondroitin sulfate solution for the microneedle tip, preparing methacrylated orthoester, preparing orthoester, preparing a non-steroidal anti-inflammatory drug solution, preparing a microneedle tip solution, preparing the microneedle and demolding the microneedle to prepare the complete soluble microneedle patch. The invention has the advantages of high drug efficiency, high efficiency in dissolving fat / water drugs, and long-acting slow release.

A microneedle array system with heterogeneous needles, designed for the enhanced transdermal delivery of bioactive agents for therapeutic and diagnostic purposes. This system includes a variety of microneedle 140 configurations, such as primary and secondary microneedles that differ in size, shape, and material to optimize delivery and functionality. Secondary needles are specifically designed with additional features such as sensors, specialized coatings, and microelectronics to perform tasks beyond simple delivery, such as in-situ detection and measurement of physiological responses, and stimulation for enhanced drug absorption and therapeutic effect.

A device for delivery of agent to a biological barrier may comprise a petal bearing main body having a set of guides each having an upstream and downstream portion. The device may further comprise a reservoir including at least one delivery sharp. The device may further comprise a plunger having a set of plunger protrusions each disposed in a respective guide. The device may further comprise a first bias member urging the plunger toward a position in which the protrusions are at an end of the downstream portions. The device may further comprise a trigger body with a first and second set of barriers. The trigger body may be displaceable between a position in which the second barriers are stowed and the first barriers obstruct displacement of the protrusions and another position in which the first barriers are stowed and the second barriers obstruct travel of the protrusions.

The application relates to a hot compress type micro-nanometer wafer medicine integrated transdermal drug delivery device, which comprises a medicine tank for storing medicine liquid, a nanometer wafer, a heating assembly, a driving assembly, a power supply and a controller; the nanometer wafer, the heating assembly and the driving assembly are connected with the medicine tank; the heating assembly and the driving assembly are connected with the power supply and the controller; a plurality of micro-needles for piercing the skin are arranged on the side of the nanometer wafer away from the medicine tank; the micro-needles are provided with through holes communicated with the medicine tank; the heating assembly is used for heating the medicine liquid in the medicine tank; the driving assembly comprises a pulse electromagnetic coil and a permanent magnet; the permanent magnet is arranged on the medicine tank; the pulse electromagnetic coil is arranged opposite to the permanent magnet and is connected with the power supply and the controller; the power supply is used for supplying power to the heating assembly and the driving assembly; the controller is used for controlling the heating temperature of the heating assembly and controlling the driving assembly to drive the nanometer wafer to perform mechanical reciprocating motion before each drug delivery.

A system includes a wearable device including a base adapted to be connected to skin of a patient. An electrochemical sensor is connected to the base. The electrochemical sensor includes a sensor medium responsive to lactate. The electrochemical sensor is in fluid connection with one or more transdermal fluid paths in connection with the base. The one or more transdermal fluid paths are configured to be placed in fluid connection with the subdermal fluid of the patient. The system further includes electronic circuitry including at least one measurement system in operative connection with the electrochemical sensor to measure a variable providing a measure of change in at least one property of the sensor medium which is dependent upon the presence of lactate in the subdermal fluid.

The invention belongs to the technical field of biological medicine, and particularly relates to a CD44 / GSH dual-response eutectic drug delivery system and a preparation method thereof.The CD44 / GSH dual-response eutectic drug delivery system comprises a microneedle array composed of a biodegradable polymer matrix formed by hyaluronic acid (HA) and poly (lactic-co-glycolic acid) (PLGA), and the microneedle array comprises a plurality of microneedles; a microneedle comprising a pharmaceutical formulation of a resveratrol-berberine co-crystal integrated into the polymer matrix; wherein the polymer matrix comprises a disulfide bond that is a glutathione (GSH) responsive switch; wherein the hyaluronic acid is capable of specifically targeting a CD44 receptor; wherein the disulfide bond can be cleaved under the condition that the concentration of glutathione in a target tissue is increased, thereby releasing the resveratrol-berberine eutectic pharmaceutical formulation; and wherein the microneedle array is configured to percutaneously deliver the resveratrol-berberine co-crystal pharmaceutical formulation to the target tissue.