151 results about "Creatine" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

Provided herein are ready-to-drink beverages at acidic and near neutral pH comprising creatine, at least one electrolyte.

The invention belongs to the technical field of gestational diabetes diagnosis marker screening, and particularly relates to a biomarker for predicting or diagnosing gestational diabetes and application of the biomarker. The invention discloses a biomarker for predicting or diagnosing gestational diabetes mellitus, the biomarker is selected from one or more of hypoxanthine, cortisol, dihydrotachysterol and cycloleucine, and more preferably, the biomarker comprises hypoxanthine, cortisol, dihydrotachysterol, (3R, 4R)-D-ketolactone, creatine, cycloleucine and L-hydroorotic acid. The seven biomarkers disclosed by the invention can predict or diagnose gestational diabetes mellitus independently or jointly through plasma detection at the early pregnancy stage, effectively improve the early diagnosis rate of gestational diabetes mellitus and improve disease prognosis, and have clinical use and popularization values.

According to the creatine-monohydrate pectin soft sweets and the preparation method, the low-amidation pectin is innovatively used in the field of the creatine-monohydrate pectin soft sweets through corresponding pretreatment, so that the problems caused by reaction and decomposition of an amphoteric compound, namely creatine monohydrate, in an original high-ester pectin system are solved; meanwhile, the problem that conventional low-amidation pectin cannot be gelatinized during pouring is solved, the low-amidation pectin and the creatine monohydrate are innovatively combined, and a gel system capable of containing a high-concentration creatine monohydrate compound is prepared. And meanwhile, by adopting a sugar-free formula technology, the requirement that sports people need to supplement creatine monohydrate but do not wish to intake sugar is met.

The present invention discloses the use of tyrosol as an enhancer of the physiological effects of creatine and its application in continuous high-intensity exercise. The enhancement of physiological effects includes, but is not limited to, improves muscle endurance, reduces decline in muscle strength, enhances utilization of creatine by muscles, stimulation of the endurance-enhancing effects of creatine, reduces the decline of endurance levels, accelerates resynthesis of phosphocreatine, increases phosphocreatine levels, improves resistance performance, and enhances endurance exercise performance. Particularly, muscle endurance after continuous high-intensity exercise does not decrease or does not decrease significantly.

The invention belongs to the field of industrial application of microalgae, and provides a method for improving astaxanthin produced by haematococcus pluvialis. Comprising the following steps: 1, culturing haematococcus pluvialis to a logarithmic phase; 2, the haematococcus pluvialis is diluted to a proper concentration, and a seed solution for producing astaxanthin from the haematococcus pluvialis is prepared; 3, respectively adding six pre-prepared inducers including creatine, glycine, 6-aminocaproic acid, glutamic acid, L-hydroxyproline and L-cysteine into the prepared haematococcus pluvialis liquid for induction; and 4, continuously filling sterile air into the haematococcus pluvialis liquid added with the inducer in a photobioreactor, culturing, and inducing haematococcus pluvialis cells to accumulate astaxanthin. The invention discloses a method for improving astaxanthin produced by haematococcus pluvialis. The haematococcus pluvialis can be promoted to accumulate a large amount of astaxanthin, and the production cycle of the astaxanthin is shortened. The method is easy to operate, high in efficiency, low in cost and completely suitable for industrial culture of haematococcus pluvialis.

The invention belongs to the technical field of biological medicine, and particularly relates to a reagent for improving ovarian development and a preparation method and application thereof. The reagent for improving ovarian development is prepared by mixing the following raw materials in parts by weight: 20-30 parts of N-acetylcysteine; 5 to 10 parts of tranexamic acid; 3 to 8 parts of creatine; and 3000 parts of water. According to the reagent, the mRNA expression of PKD1P6 and follicle stimulating hormone receptors (FSHR) in ovarian tissues is up-regulated, the activity and functions of cumulus granular cells are enhanced, and apoptosis of the cumulus granular cells is inhibited, so that the effects of effectively promoting follicle development and inhibiting the apoptosis of the cumulus granular cells are achieved.

The disclosure is directed to methods related to creatinine, for example, a method for its safe administration to a human.

Devices, kits, and methods for testing and monitoring creatine phosphokinase (CPK) in biological samples are provided.

The invention relates to the technical field of biological medicine, in particular to application of a creatine related gene detection reagent in preparation of breast cancer prognosis products. The creatine related gene is an IGFBP1 gene and / or a TBC1D4 gene. According to the method, the expression levels of IGFBP1 and TBC1D4 genes in breast cancer patient samples are detected, a risk score is calculated by using a random survival forest (RSF) model, and the one-year, two-year and three-year survival rates of breast cancer patients are accurately predicted according to the risk score result. Meanwhile, the invention proves that IGFBP1 and TBC1D4 genes can be used as potential targets for breast cancer treatment, the IGFBP1 and fulvestrant as well as the TBC1D4 and vinblastine have stable binding capacity, and a new basis is provided for selection of individualized treatment medicines for breast cancer.

The present invention provides a method for improving exercise performance or preventing or relieving fatigue in mammal, including administration to the mammal a composition including: (i) an effective amount of BAIBA, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof; and (ii) an effective amount of creatine. The present invention also provides a composition, including (i) an effective amount of BAIBA, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof; and (ii) an effective amount of creatine, for improving exercise performance or preventing or relieving fatigue in a mammal. The methods and compositions of the invention can be used for enhancing muscle strength, increasing muscle content, improving muscle endurance; preventing body fatigue after exercise, accelerating recovery after exercise.

The invention provides a high-protein feed raw material and a preparation method thereof, and belongs to the field of protein feeds.The preparation method comprises the steps that animal-derived organs are selected, an animal-derived organ enzyme solution is obtained through a pretreatment means, and natural protein components in the animal-derived organ enzyme solution are reserved to serve as crude protein nutritional ingredients; step 2, adding a substrate and a methyl donor into the animal-derived visceral organ enzyme liquid, and generating guanidinoacetic acid and creatine through an enzymatic synthesis reaction to obtain a mixed liquid; and step 3, carrying out enzyme system inactivation, centrifugal filtration, drying and crushing on the mixed solution to obtain a finished product. According to the invention, guanidinoacetic acid and creatine are synthesized by in-situ catalysis of animal-derived visceral organ natural enzyme systems, and can be naturally fused with protein components, so that the problem of compatibility is avoided, and growth functional factors do not need to be added from an external source; natural enzyme systems of animal livers and kidneys are directly utilized, industrial enzymes do not need to be purchased, and the natural enzyme systems are more adaptive to a raw material system; protein, natural enzyme systems and mineral substances in the raw materials are synchronously utilized, so that one material has multiple purposes.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The application relates to the technical field of component detection, and discloses an analysis and detection equipment based on a creatine sodium finished product, which comprises a detection mounting table, a telescopic assembly, a rotating assembly, a power assembly, a temporary storage assembly, a mixing pretreatment equipment and an analysis and detection equipment; the temporary storage assembly comprises a compression bag, a flexible liquid inlet, a one-way valve and a pressure relief valve; through the flexible compression bag and the one-way valve structure of the temporary storage assembly, the application realizes pressure-free injection of the sample, avoids poor liquid inlet or early liquid leakage caused by air pressure imbalance, adopts a servo motor and a speed reducer in cooperation with the power assembly, realizes accurate indexing in cooperation with the rotating assembly, ensures that the temporary storage assembly is stably aligned with the liquid outlet position, realizes controllable pressure liquid outlet through mechanical extrusion of the telescopic assembly, realizes stable sample delivery, non-deviation and uniform flow, and realizes smooth connection with the mixing pretreatment equipment, so that the creatine sodium detection precision and efficiency are greatly improved, and the structure is stable and reliable and easy to maintain.

It suppresses the decrease in creatine content over time. [Solution] The cosmetic composition contains zinc element (A), creatine (B), and creatinine (C).

The invention provides a creatine monohydrate synthesis reaction device, and belongs to the technical field of creatine monohydrate production. Comprising a plate-and-frame filter, a filter frame is mounted in the middle of the plate-and-frame filter, and a speed brake is fixedly connected to the bottom of the filter frame; the dip angle scraping assembly is used for being matched with a worker to scrape a filter cake on the filter frame, and the dip angle scraping assembly is connected with the portal frame. By arranging the dip angle scraping assembly, when filter cakes are scraped, a scraper on a speed brake can slowly scrape the filter cakes from bottom to top along a filter frame, and due to the fact that the scraper is designed in an inclined mode, the contact area between the scraper and the filter cakes is small, excessive filter cake residues attached to the scraper can be reduced, and the resistance for cutting into a viscous layer can be greatly reduced; therefore, the filter cake is scraped more easily, the scraping efficiency is improved, the forming capacity of the filter cake is improved, and effective judgment of the NIR moisture meter on the moisture content of the filter cake in the subsequent drying process is facilitated.

This invention relates to an anti-wrinkle repair composition containing red camellia extract and its application. The anti-wrinkle repair composition of this invention comprises the following components in weight percentages: polyol 1: 1-25%; red camellia extract: 0.1-15%; creatine: 0.1-2%; carnosine: 0.01-0.5%; recombinant collagen: 0.01-5%; tetrahydrocurcumin inclusions: 1-20%; ergothioneine: 0.0001-1%; water: balance. This invention combats aging through multiple pathways and approaches, providing multi-dimensional skin anti-oxidation and anti-glycation, scavenging free radicals, promoting the production of type I collagen in the skin's extracellular matrix, and strengthening the skin barrier. This composition can be used as an active ingredient in various types of cosmetics, including aqueous solutions, lotions, creams, and shampoos.

The subject matter of the present invention is a creatine agglomerate with improved solubility characteristics in aqueous systems and improved handling, thus simplifying the intake of creatine. The agglomerate is characterized in that it contains 30 to 99.9 wt. % of ground creatine and / or ground creatine derivatives and / or ground creatine salts and 0.1 to 30 wt. % of a binder containing at least one oligosaccharide, in particular maltodextrin, based on the total weight of the agglomerate.

The invention belongs to the technical field of analytical chemistry, and discloses a method for detecting creatinine in a creatine product, which comprises the following steps: (1) precisely weighing a sample, adding a buffer solution, carrying out vortex oscillation dissolution, volume metering, shaking up, centrifuging, and passing through a water phase filter membrane to obtain a creatine test solution; (2) a creatine test solution is taken, a liquid chromatograph is adopted for liquid phase detection, and the liquid chromatography conditions are as follows: an SCX chromatographic column is adopted, an ammonium dihydrogen phosphate solution is taken as a mobile phase for isocratic elution, an ultraviolet detector is adopted, and the content of creatinine is obtained according to a liquid phase detection result. According to the method, the situation that the detection result of the creatinine in the creatine product is virtually high can be remarkably reduced, accurate quantification of the creatinine byproduct creatinine is achieved, and a more perfect data basis is provided for quality control of the creatine product.

Disclosed herein are nutritional compositions aimed at promoting longevity and wellness. The compositions are formulated for oral intake and include a variety of nutrients and functional compounds such as proteins, creatine, antioxidants, vitamins, minerals, hyaluronic acid, biotin, CoQ10, spermidine, and one or more NAD+ precursors. These components may serve to enhance muscle health, antioxidant function, skin, hair and joint health, cellular and cardiovascular health, thus contributing to the overall vitality and lifespan of an individual.

This invention discloses a creatine amidoside hydrolase mutant for creatinine detection, along with methods for selecting, purifying, and detecting the mutant site. The mutant is a single-point mutation of the wild-type full-length amino acid sequence of the creatine amidoside hydrolase protein (Af-CRE) from Alcaligenes faecalis. This invention utilizes machine learning-assisted site-directed mutagenesis to create a creatine amidoside hydrolase mutant with enhanced activity, obtaining a mutant enzyme with improved activity and certain thermostability. Furthermore, it provides methods for purifying and detecting the mutant, overcoming the shortcomings of existing creatine amidoside hydrolases with poor activity that cannot meet the requirements for reagent applications. This lays the foundation for further expanding the industrial applications of creatine amidoside hydrolases.

The application provides a creatine monohydrate synthesis reaction device and belongs to the technical field of creatine monohydrate production. The device comprises a plate-and-frame filter, a filter frame is installed at the middle position of the plate-and-frame filter, and a deceleration plate is fixedly connected to the bottom of the filter frame. An inclination scraping assembly is used to scrape the filter cake on the filter frame in cooperation with workers, and the inclination scraping assembly is connected with the portal frame. The inclination scraping assembly is provided, and when the filter cake scraping operation is performed, the scraper on the deceleration plate can slowly scrape from bottom to top along the filter frame. Since the scraper is designed to be inclined, the contact area with the filter cake is small, which can not only reduce the excessive filter cake residues adhered to the scraper, but also greatly reduce the resistance of cutting into the viscous layer, so that the filter cake can be scraped more easily, the scraping efficiency is improved, and the forming capacity of the filter cake is improved, which facilitates the effective determination of the NIR moisture meter on the filter cake moisture content in the subsequent drying process.

1. The name of the product of this design: Packaging barrel (Notland ImmPower Creatine Energy Powder). 2. Purpose of this design product: for packaging. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view.

The present invention relates to a pharmaceutical composition comprising creatine or physiologically acceptable derivatives and / or salts and or adducts thereof for use in the treatment of breathing difficulties, chest pain, body aches etc. after virus infection particularly in combination with breathing exercises. A further embodiment of the invention relates to the use of a composition comprising creatine or physiologically acceptable derivatives and / or salts and or adducts thereof as dietary supplement for preparation of a diet supporting the recovery from breathing difficulties, chest pain, body aches etc. by breathing exercises after a viral infection of the lungs or lower respiratory system.

Techniques includes measuring, using a creatine sensor, a creatine sensor current signal (ΔI2) of a first calibration solution (CS2). A creatine sensor sensitivity (Slope) for the creatine sensor is based on the creatine sensor current signal (ΔI2). The first calibration solution (CS2) has a known concentration of creatine (CR_CS2), a known concentration of creatinine (CREA_CS2), and a stable ratio of creatine to creatinine over a range of temperatures for a predefined shelf-life of the first calibration solution (CS2). The Techniques include measuring, using the creatine sensor, a measured creatine concentration (MCR_CS3) of a second calibration solution (CS3). The second calibration solution (CS3) has an initial known creatine concentration (CR_CS3), an initial known creatinine concentration (CREA_CS3), and an unstable ratio of creatine to creatinine that changes over the predefined shelf-life. Concentrations of creatine and creatinine in a sample are thereafter estimated.

The invention discloses a biosynthesis process of creatine monohydrate, and belongs to the technical field of bioengineering. The invention discloses a creatine monohydrate biosynthesis method, which is characterized in that sarcosine invertase is utilized to catalyze chloroacetic acid and monomethylamine to generate N-alkylation reaction so as to prepare sarcosine, and then creatine monohydrate is generated under the catalysis of the creatine invertase, the process is mild in reaction condition, the temperature is 25-37 DEG C, the pH is 6.0-8.0, the energy consumption is lower, the conversion efficiency is high, the environment is protected, and the economical efficiency is high. The invention provides a new synthesis method for sustainable synthesis of creatine monohydrate, and provides a new idea for industrial production of creatine monohydrate.

Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

The invention belongs to the technical field of biology, and particularly relates to application of creatine in relieving heat stress injury of bovine mammary epithelial cells. It is innovatively found for the first time that creatine can improve the activity of bovine mammary epithelial cells suffering from heat stress, reduce the apoptosis amount, caused by heat stress, of the bovine mammary epithelial cells, inhibit expression of pro-apoptosis genes and promote expression of anti-apoptosis genes, and the method provides a new method for relieving or treating bovine heat stress injury, and has the advantages that the creatine is used for treating bovine heat stress injury; the composition can also be used as a protective agent for cattle to resist heat stress.

The invention belongs to the technical field of nutritional supplements, and particularly relates to a novel nutritional composition and application thereof. Comprising creatine monohydrate and a Chinese wolfberry extract, and the weight ratio of the creatine monohydrate to the Chinese wolfberry extract is (0.5: 1)-(3: 1). Experiments find that after a human body takes the nutritional composition, the content of phosphocreatine PCr in muscles can be increased by 14%-19%, the 1-RM strength can be increased by 6.1%-8.5%, and it is indicated that the nutritional composition has the effect of improving the functional muscle strength and the phosphocreatine level. And the effect generated by the nutritional composition is far beyond the sum of the independent effects of all the components, so that the combination of the creatine monohydrate and the wolfberry extract has an unexpected and non-obvious synergistic effect in the aspects of improving the functional muscle strength and the creatine phosphate level.

A composition comprising at least one creatine fatty ester or salt thereof, at least one omega 3 fatty acid or salt thereof and at least one glyceride for use in medicine, the composition being free of non ionic surfactants and in particular said composition for use in treating the brain creatine transporter deficiency disease.