26 results about "Creatine" patented technology

The disclosure is directed to methods related to creatinine, for example, a method for its safe administration to a human.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The application relates to the technical field of component detection, and discloses an analysis and detection equipment based on a creatine sodium finished product, which comprises a detection mounting table, a telescopic assembly, a rotating assembly, a power assembly, a temporary storage assembly, a mixing pretreatment equipment and an analysis and detection equipment; the temporary storage assembly comprises a compression bag, a flexible liquid inlet, a one-way valve and a pressure relief valve; through the flexible compression bag and the one-way valve structure of the temporary storage assembly, the application realizes pressure-free injection of the sample, avoids poor liquid inlet or early liquid leakage caused by air pressure imbalance, adopts a servo motor and a speed reducer in cooperation with the power assembly, realizes accurate indexing in cooperation with the rotating assembly, ensures that the temporary storage assembly is stably aligned with the liquid outlet position, realizes controllable pressure liquid outlet through mechanical extrusion of the telescopic assembly, realizes stable sample delivery, non-deviation and uniform flow, and realizes smooth connection with the mixing pretreatment equipment, so that the creatine sodium detection precision and efficiency are greatly improved, and the structure is stable and reliable and easy to maintain.

It suppresses the decrease in creatine content over time. [Solution] The cosmetic composition contains zinc element (A), creatine (B), and creatinine (C).

Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

This invention provides urolithin A cocrystals, their preparation methods, compositions, and applications. Specifically, this invention provides a urolithin A cocrystal with high bioavailability, wherein the urolithin A cocrystal is selected from the group consisting of: urolithin A-proline cocrystals, urolithin A-carnitine cocrystals, urolithin A-nicotinamide cocrystals, or urolithin A-creatine cocrystals. Compared to urolithin itself, the urolithin A cocrystals of this invention exhibit high stability, a significantly lower melting point, and significantly improved solubility and bioavailability. Furthermore, the preparation method is simple, easy to control, and has good reproducibility, allowing for stable acquisition of the target cocrystal. The composition containing the cocrystal, prepared by grinding, has high yield, low cost, and is suitable for large-scale production.

This invention belongs to the field of organic synthesis technology, specifically relating to a creatine glycinate and its preparation method, comprising the following steps: pretreatment, drying creatine monohydrate, passing glycine through a 100-mesh sieve and storing it in a desiccator for later use, and selecting a reaction solvent; raw material dissolution, adding the reaction solvent to a reaction vessel, starting stirring and heating, adding creatine monohydrate, and stirring at a constant temperature until completely dissolved, finally obtaining a creatine solution; complexation reaction, adding glycine, increasing the stirring rate and heating after the addition is complete, maintaining the temperature for the complexation reaction, using staged stirring until the complexation reaction is complete; after the reaction is complete, using a gradient cooling method; crystallization and ripening, followed by constant temperature and low-speed stirring for 2 hours, then allowing the crystals to settle completely; after filtration, vacuum drying is performed to finally obtain creatine glycinate. This application solves the problems of uneven reaction, poor crystal quality, and low purity and yield in existing processes, achieving efficient and high-quality preparation of creatine glycinate.

This invention belongs to the field of organic synthesis technology, specifically relating to creatine nitrate and its preparation method, including the following steps: raw material pretreatment, pretreating creatine monohydrate; adding 600g of reaction solvent to a reaction vessel, stirring, adding 150g of purified creatine monohydrate from step 100, mixing evenly to obtain a reaction solution, and heating to 50-55℃; slowly adding 110g of 65% nitric acid dropwise to below the surface of the reaction solution, and after the addition is complete, maintaining the temperature at 50-55℃ for 2 hours to obtain a mixed solution; cooling the mixed solution to 0-5℃ at a cooling rate, adjusting the stirring rate, and stirring at a constant temperature for 2 hours to crystallize; filtering the above crystallization system, washing the filter cake 2-3 times with a cold solvent at 0-5℃; vacuum drying the filter cake, and sieving after drying to obtain the creatine nitrate product. This invention achieves efficient and stable preparation of creatine nitrate, significantly improving product yield and purity.

The utility model relates to a kind of creatinine electrochemical detection test paper, belong to detection equipment technical field, especially creatinine electrochemical detection equipment technical field.The utility model is equipped with two groups of detection electrode with non-closed frame electrode structure and two independent blood tank channels opened by double-sided adhesive layer, the reaction of creatinine in blood sample and the reaction of creatine are independently carried out in two blood tanks, creatinine and creatine signals in blood sample can be detected simultaneously without mutual interference, so that the detection of creatinine is more accurate.In addition, the compact multilevel test paper structure design of the utility model not only reduces the volume of test paper, but also the design and layout of reasonable blood tank channel, escape gas port and detection electrode can facilitate the precise use of detector.

The application discloses creatine composition for improving exercise endurance and strength, and a preparation method and application thereof. The creatine composition comprises creatine, black pepper extract and oyster peptide. The scheme has the effects of significantly enhancing energy systems, promoting anabolism, inhibiting catabolism, reducing oxidative damage and accelerating recovery through the combination of components, and can be effectively used for improving exercise endurance and strength.

This invention proposes a creatine salt, belonging to the field of organic synthesis technology. Through steps such as feeding and mixing, dropwise reaction, cooling and crystallization, and post-treatment, it uses low-carbon alcohols such as methanol and ethanol as reaction solvents, and a low-carbon alcohol solution of hydrogen chloride instead of traditional concentrated hydrochloric acid as the hydrogen chloride source. This completely avoids the introduction of large amounts of water, effectively suppresses side reactions such as hydrolysis, significantly reduces the impurity content in the product, and achieves a product purity of up to 99.9%. Secondary recrystallization is unnecessary, simplifying the process. The reaction solvent can be recovered and reused through distillation, significantly reducing the generation of waste and environmental treatment costs, conforming to the production concept of green chemistry, and suitable for large-scale industrial production.

967.526NL1 Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

The present application belongs to the technical field of hydrogel materials, and particularly relates to a composite hydrogel for regulating energy metabolism and a preparation method and application thereof. The preparation raw material of the composite hydrogel for regulating energy metabolism comprises creatine modified double bond hydroxybutyl chitosan, hydroxyapatite, curcumin, an initiator and a solvent. CHBC provides energy metabolism support at the cell level, is conducive to the proliferation and differentiation of osteogenesis-related cells; HA provides an inorganic environment similar to bone mineralization, and plays a bone conduction and bone induction role; Cur regulates inflammatory response and improves oxidative stress state, and optimizes the repair microenvironment. Through synergy in different aspects such as energy metabolism support, structure mineralization and microenvironment regulation, the regulation of the energy metabolism state of cells in the bone repair area is realized, which is conducive to meeting the high energy requirement of osteoblasts in the repair process, and can promote new bone formation and improve the inflammatory and oxidative stress microenvironment of the injury area, and provides more favorable repair conditions for bone tissue regeneration.

An evaluation method is performed by an arithmetic circuit and includes obtainment processing (S1), evaluation processing (S2), and presentation processing (S3). The obtainment processing (S1) obtains: image information on a sectional image representing an interested section of an organism including a target section of a testis of the organism generated by use of magnetic resonance of hydrogen atoms; and concentration information on a creatine concentration in the interested section measured by use of magnetic resonance based on chemical exchange saturation transfer. The evaluation processing (S2) generates an evaluation image representing a distribution of evaluation results of a testicular function in the target section based on the concentration information. The presentation processing (S3) presents the sectional image and the evaluation image.

The utility model relates to the technical field of production of creatine pyruvate, in particular to a crystallization device for creatine pyruvate. The upper side wall of the crystallization kettle is fixedly installed with a kettle cover, and the top of the kettle cover is fixedly connected with two feed pipes in a symmetrical manner. When the upper end of the top block is in contact with the side wall of the embedded groove, the baffle blocks the leakage hole, the crystal seeds can be put into and temporarily stored in the inside of the storage cylinder through the feed pipe, when feeding is needed, the motor drives the stirring rod to rotate slowly, the stirring rod drives the two storage cylinders to rotate synchronously, the side wall of the embedded groove and the chamfer push the top block downward, the top block drives the baffle to move downward synchronously through the extension rod, when the top block completely slides out of the embedded groove and is in contact with the lower side wall of the positioning ring, the baffle moves downward to below the leakage hole, the crystal seeds in the storage cylinder fall into the solution evenly under the action of gravity through the opened leakage hole, so that the uniform scattering of the crystal seeds in the solution is realized, and the crystallization efficiency and product quality are improved.

This invention provides a creatine citrate and its preparation method. In this method, creatine monohydrate is used as the creatine source, and creatine monohydrate reacts with citric acid in a reaction solvent. The creatine citrate is obtained through temperature-controlled reaction, temperature-controlled crystallization, filtration, and drying. The product obtained by this invention has a molar yield ≥90% and a purity ≥99.6%. The obtained creatine citrate is a white crystalline powder and can be widely used in food and beverage additives, health products, pharmaceutical raw materials, daily chemical raw materials, and feed and veterinary drug additives.

This invention belongs to the technical field of functional sports nutrition foods, specifically relating to a composition containing inactivated Akkermansia myxophilus for improving athletic performance. Existing sports nutrition products often have only a single effect. The composition of this invention contains inactivated Akkermansia myxophilus, leucine, creatine, zinc, and magnesium. This invention achieves muscle gain, fat loss, reduction of post-exercise soreness, and improved recovery speed by promoting muscle synthesis, enhancing strength, and promoting fat breakdown. The composition of this invention is stable at room temperature and can be formulated into a powder for post-exercise consumption.

The application discloses a probiotic and creatine composition with an antidepressant effect and application thereof, and contains bifidobacterium and creatine, has small toxic side effects, long-term effects, and low prices, and has wide application prospects. The application finds that the content of creatine in feces increases, and the content of creatine in blood and brain decreases in the occurrence of depression; and finds that the abundance of pseudolongum bifidobacterium and adolescent bifidobacterium in feces decreases in the occurrence of depression. The combined use of pseudolongum bifidobacterium and creatine or adolescent bifidobacterium and creatine can significantly increase the antidepressant effect of creatine. Experimental research proves that the medicine containing effective amounts of bifidobacterium and creatine as active ingredients has small toxic side effects, long-term effects, and low prices in the prevention and treatment of depression.

This invention proposes a method for preparing creatine phosphate, belonging to the fields of pharmaceutical chemistry and food additives. The method involves dissolving raw materials, dropwise reaction, cooling crystallization, and post-processing to prepare creatine phosphate. The process is short, with mild reaction conditions, requiring no special high-pressure or corrosion-resistant equipment, and eliminating the need for complex purification processes. This significantly reduces energy consumption and labor costs, enabling direct industrial-scale continuous production. Furthermore, this application uses purified water, methanol, and ethanol as reaction solvents, which are low in toxicity and environmentally friendly, eliminating the risk of high-risk solvent residues. The solvents can be recovered and reused through conventional distillation, significantly reducing raw material costs and waste emissions, meeting the requirements of green chemical production. The target product achieves a molar yield of up to 91% and a stable purity of ≥99.8%, directly meeting the high-end application requirements of food and pharmaceutical grades, resulting in strong market competitiveness.

A solid supplement composition comprising at least one non-ester nitrate compound and at least one isolated amino acid compound, wherein the at least one isolated amino acid compound is creatine, wherein the at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound, and wherein the solid supplement composition comprises an amount of nitrate ion (NO3-) that is at least 0.05625 mg. A semisolid supplement composition comprising at least one non-ester nitrate compound and at least one isolated amino acid compound, wherein the at least one isolated amino acid compound is creatine, wherein the at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound, and wherein the semisolid supplement composition comprises an amount of nitrate ion (NO3-) that is at least about 0.05625 mg.

This invention relates to a multifunctional bio-based modifier, its preparation method, and its uses, belonging to the field of PLA composite materials. By weight, it comprises 10 parts adenosine monophosphate, 5-8 parts β-cyclodextrin, and 3-4 parts creatine. The preparation method includes the following steps: (1) adding 10 parts adenosine monophosphate and 4-5 parts of a 37%-40% formaldehyde aqueous solution to 200 parts of water, heating to 75-85℃, and reacting for 1-2 hours; (2) after the reaction, adding 5-8 parts β-cyclodextrin, heating to 80-100℃, and reacting for 2-3 hours; (3) finally adding 3-4 parts creatine, cooling to 45-55℃, and reacting for 1.5-2.5 hours. After filtration, washing, and drying, the multifunctional bio-based modifier is obtained. The multifunctional bio-based modifier of this invention can impart flame retardant, toughening, UV aging resistance, and recyclability to PLA at low addition levels, thus showing good industrial application prospects.

A liquid collagen supplement comprising at least 15,000 mg of collagen and at least one of: creatine; biotin; and / or electrolyte(s). Preferably, the supplement comprises 15,000-30,000 mg of collagen,

It suppresses the decrease in creatine content over time. [Solution] The topical composition contains creatine and creatinine in a specific mass ratio.

This invention discloses a biomarker combination for glioma risk screening or auxiliary diagnosis and its application. The biomarker combination comprises creatine, lactate, succinic acid, N,N-dimethylglycine, 2-oxoglutarate, acetic acid, and glutamate. Based on the biomarker combination provided by this invention, a clinical diagnostic model for assessing glioma risk can be constructed using algorithms such as multivariate logistic regression. The constructed clinical diagnostic model has high sensitivity and specificity, and can quickly and accurately assess the glioma risk of subjects, making it suitable for early screening and auxiliary diagnosis of adult gliomas.

Composition containing alkaline stabilizers (10) for encapsulating creatine hydrates, characterized by that the composition (10) for encapsulating creatine hydrates comprises a hydrogel encapsulation structure (11) and a plurality of creatine composition units (12), wherein each creatine composition unit (12) consists of a creatine monomer (121) and an alkaline stabilizer (122), wherein the hydrogel encapsulation structure (11) is capsule-shaped and has a three-dimensionally cross-linked gel matrix (11), wherein the creatine monomer (121) comprises 50-99.99% and the alkaline stabilizer comprises 0.01-50% of the creatine composition unit (12), wherein the creatine composition units (12) are encapsulated in the gel matrix (11); that the base material of the gel matrix (11) is selected from the group consisting of gum arabic, pectin, guar gum, locust bean gum, gellan gum, carrageenan, agar, xanthan gum, carboxymethylcellulose, gelatin, fucoidan, modified starch, starch, maltodextrin and poorly digestible maltodextrin; that the creatine monomer (121) is a variety of creatine molecules; and the alkaline stabilizer (122) consists of a variety of alkaline metal ions or their compounds.