515 results about "Hydroxybutyric acid" patented technology

The invention discloses a pure bio-based polyhydroxyalkanoate adhesive as well as preparation and application thereof, and belongs to the technical field of degradable adhesives. According to the adhesive, polyhydroxybutyrate valerate or polyhydroxybutyrate hexanoate is used as a matrix, and the acid value reaches 2-15 mg KOH / g through molten end group activation; a reactive emulsifier with a hydrophilic-lipophilic balance value of 9-12 is introduced into a water phase, and the stable aqueous dispersion is prepared through phase inversion high-shear emulsification. The Z-average particle size of the dispersion is 0.12-0.30 [mu] m, and the content of the free surfactant is not higher than 30wt%. After the tackifying resin, the plasticizer and the vegetable wax are compounded, the bio-based carbon content of the obtained adhesive is not lower than 95%, and the volatile organic compound content is not higher than 100 mg / kg. The paper / paper heat sealing strength of the adhesive is not lower than 7.0 N / 15mm, the 180-degree peel strength is not lower than 7.5 N / 25mm, and the adhesive can pass repulping evaluation.

Compositions for inducing and maintaining a state of flow in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

The invention provides a recombinant strain for controllably synthesizing high-proportion 4-hydroxybutyric acid (4HB) polyhydroxyalkanoate (PHA) as well as a construction method and application of the recombinant strain. The recombinant strain disclosed by the invention can be used for efficiently producing high-proportion poly (3-hydroxybutyrate-4-hydroxybutyric acid) (P34HB for short) by using glucose as a unique carbon source or a 4HB structure related or non-related carbon source in amplification production of a shake flask, a 7L fermentation tank, a 100L fermentation tank and a 5000L fermentation tank.

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

Provided is a poly(3-hydroxybutyrate) resin tube including a poly(3-hydroxybutyrate) resin, the tube having a wall thickness of 0.1 to 0.6 mm. The difference between the melting point peak temperature and the melting point peak end temperature in differential scanning calorimetry analysis of the poly(3-hydroxybutyrate) resin is preferably 10° C. or higher. Preferably, production of the tube includes the step of melting a poly(3-hydroxybutyrate) resin in an extruder, then extruding the resin from an annular die, and introducing the resin into water, the annular die temperature being set to a temperature between the melting point peak temperature and the melting point peak end temperature in differential scanning calorimetry analysis of the poly(3-hydroxybutyrate) resin.

The invention provides a polyarylester nanofiber and a preparation method thereof, and the preparation method comprises the following steps: firstly, carrying out acetylation reaction on 4-hydroxybenzoic acid (HBA) and 6-hydroxy-2-naphthoic acid (HNA) to obtain acetylated HBA and acetylated HNA, and then carrying out copolymerization on acetylated HBA and acetylated HNA and 4-hydroxybutyric acid (GHB) to obtain HBA / GSB / HNA copolymerized arylester granules B; the preparation method comprises the following steps: carrying out blending spinning on granules B and HBA / HNA copolymerized aromatic ester granules A obtained by copolymerizing acetylated HBA and acetylated HNA in the prior art, putting the obtained blended polyarylate fibers into an organic solvent containing a strong base, carrying out chemical etching and deprotonation, carrying out disassembly from top to bottom to obtain a polyarylate nanofiber suspension, and finally carrying out suction filtration and drying to obtain the polyarylate nanofibers. According to the preparation method disclosed by the invention, the blended polyarylester fiber containing an aliphatic chain is subjected to etching and deprotonation treatment through strong base to disassemble the polyarylester nanofiber, and a certain amount of-CH2-structure is introduced into a main chain, so that disassembly preparation of the nanofiber is facilitated, and the polyarylester nanofiber with uniform diameter and length and controllable length-diameter ratio is obtained.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The invention provides a bio-based 1, 4-butanediol composition as well as a preparation method and application thereof, and the bio-based 1, 4-butanediol composition comprises bio-based 1, 4-butanediol, 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether. The total mass content of 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether in the bio-based 1, 4-butanediol composition is 51 to 220 ppm. The bio-based 1, 4-butanediol composition has low hygroscopicity, and can maintain low water content after long-term storage; meanwhile, when the bio-based 1, 4-butanediol composition is used for polyester synthesis, the esterification time can be shortened, the reaction efficiency can be improved, side reactions can be reduced, and a polyester product with better damp-heat resistance stability can be obtained.

Compositions for inducing and maintaining a state of flow in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and / or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.

A beverage can include D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate / D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and / or D hydroxybutyric acid of at least 0.5 percent by volume. The percentage of D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate / D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and D hydroxybutyric acid can be between 5 and 19 percent, or can be higher than 19 percent. The beverage can be improved by the incorporation of flavor from hops and / or from other ingredients.

The invention provides a composite quality control liquid for an electrochemical multi-parameter detector. The composite quality control liquid comprises a buffer volume, a quality control substance and a stabilizer, the stabilizing agent comprises 5 to 50 g / L of bovine serum albumin, 0.1 to 10 g / L of EDTA-2Na (Ethylene Diamine Tetraacetic Acid), 10 to 100 g / L of a viscosity regulator, 0.3 to 25 g / L of a preservative and 5 to 20 g / L of a surfactant; the preparation method comprises the following steps: adding components of the stabilizer into a buffer system, preparing a preparation solution, preparing mother liquor of each quality control substance, proportionally mixing glucose mother liquor, uric acid mother liquor, beta-hydroxybutyric acid mother liquor and cholesterol sodium sulfate and triglyceride composite mother liquor according to the target concentration of the quality control solution, and fixing the volume by using the preparation solution to obtain the quality control liquid. And fully and uniformly mixing to obtain the composite quality control liquid. The composite quality control liquid can ensure that uric acid is not degraded, cholesterol triglyceride is not separated out, the formula is mild, and active substances in a detection system are not influenced.

A beverage can include D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate / D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and / or D hydroxybutyric acid of at least 0.5 percent by volume. The percentage of D ethyl 3-hydroxybutyrate, D 1,3-butanediol, D Beta hydroxybutyrate salts, D Beta hydroxybutyrate / D 1,3-butanediol monoester, D ethyl hydroxybutyrate, hydroxybutyrate, and D hydroxybutyric acid can be between 5 and 19 percent, or can be higher than 19 percent. The beverage can be improved by the incorporation of flavor from hops and / or from other ingredients.

The invention discloses a self-degradable granular temporary plugging agent for fracturing as well as a preparation method and application thereof, and relates to the technical field of oilfield chemistry. The temporary plugging agent is prepared by melting, blending and crushing the following materials in percentage by mass: 70%-85% of poly (3-hydroxybutyrate-co-4-hydroxybutyrate), 10%-20% of poly (3-hydroxybutyrate-co-4-hydroxybutyrate), 10%-20% of poly (3-hydroxybutyrate), 2%-10% of an auxiliary agent for assisting degradation; 10%-15% of nano silicon dioxide; 1%-7% of sodium starch glycolate. The temporary plugging agent disclosed by the invention contains the disintegrant glycolic acid starch sodium which is extremely high in water absorption capacity, and can rapidly absorb water and expand the volume of the temporary plugging agent by 250-300 times, so that the temporary plugging agent expands to generate cracks, on one hand, gaps among particles can be reduced after the temporary plugging agent absorbs water and expands in the early stage of plugging, and the compactness of a whole plugging layer is increased; on the other hand, cracks are generated on the surface of the temporary plugging agent after expansion, and water can permeate into temporary plugging agent particles from the cracks, so that the contact area between the temporary plugging agent and the water is increased, the degradation of the temporary plugging agent is promoted, and the overall degradation time is shortened.

The present invention discloses a self-degradable particle temporary plugging agent for fracturing and its preparation method and application, relating to the field of oilfield chemical technology. According to mass percentage, the temporary plugging agent is obtained by melt blending and crushing the materials including the following components: poly (3-hydroxybutyric acid-co-4-hydroxybutyrate), 70%-85%; auxiliary agent for auxiliary degradation, 2%~10%; nano silicon dioxide 10%~15%; sodium starch glycolate, 1%~7%. The temporary plugging agent of the present invention contains disintegrant sodium starch glycolate, which has a strong water absorption capacity and can quickly absorb water and expand its own volume by 250~300 times, so that the temporary plugging agent expands and cracks appear. On the one hand, in the early stage of plugging, the temporary plugging agent can reduce the gap between particles after absorbing water and expanding, thereby increasing the density of the entire plugging layer, thereby improving the plugging ability. On the other hand, cracks are generated on the surface of the temporary plugging agent after expansion, and water can penetrate into the interior of the temporary plugging agent particles from the cracks, which increases the contact area between the temporary plugging agent and water, thereby promoting its degradation and shortening the time of overall degradation.

The invention discloses a composite medical suture and a preparation method thereof, and belongs to the field of biomedicine. In order to solve the problems that an existing medical suture is poor in antibacterial effect and biological safety, the composite medical suture comprises a core layer, a degradation regulation and control layer, a slow release layer and an antibacterial layer which are sequentially arranged from inside to outside; the core layer is prepared from a blend fiber of poly (hydroxybutyrate-hydroxyvalerate) and polycaprolactone-co-polyglycolide; the degradation regulation and control layer comprises a mixture of at least two kinds of polyethylene glycol with different molecular weights; the slow release layer comprises quaternary ammonium salt loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. Through the synergistic effect of the four layers, the comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function is realized; the purposes of improving the slow-release antibacterial performance, reducing damage to the human body, reducing inflammation and the like are achieved, and the antibacterial and degradation effects meet the recovery requirements.

The invention relates to the technical field of medicine, in particular to application of beta-hydroxybutyric acid in preparation of medicine for preventing and / or treating osteoporosis, the osteoporosis comprises postmenopausal osteoporosis and diabetic osteoporosis due to estrogen deficiency, the administration concentration of the beta-hydroxybutyric acid is 150mM, and the administration concentration of the beta-hydroxybutyric acid is 10mM. According to the application of the beta-hydroxybutyric acid in preparing the medicine for inhibiting osteoclast differentiation or osteoclast formation, the beta-hydroxybutyric acid inhibits osteoclast precursor cells from being differentiated into osteoclasts, and the administration concentration of the beta-hydroxybutyric acid is 10 mM; the invention proves that the beta-hydroxybutyric acid improves bone microstructures of OVX mice and db / db mice, inhibits osteoclast differentiation and reduces bone resorption, and provides a new target for prevention and treatment of osteoporosis.

The invention discloses a neutral organic chelating cleaning agent for a boiler, and belongs to the field of chemical cleaning of boiler superheaters of thermal power plants. The cleaning agent is prepared from the following components in percentage by weight: 0.5%-5% of ethylenediamine tetraacetic acid ammonium, 0.1%-4% of acetic acid or ammonium acetate, 0.1%-3% of glycollic acid ammonium or glycollic acid, 0.1%-5% of a pH regulator, 0.1%-1% of a cosolvent, 0.2%-0.8% of a corrosion inhibitor SH369, 0.1%-0.6% of a reducing agent, 0.0%-0.3% of a defoaming agent, 0.0%-0.2% of a surfactant and 84%-93% of water, wherein the pH value of the cleaning agent is 6-8; the cosolvent is tartaric acid and / or hydroxybutyl diacid, the surfactant is nonylphenol polyoxyethylene ether, and the reducing agent is hydrazine. The cleaning agent disclosed by the invention has good dissolving capacity on oxide skin, does not generate precipitates to cause pipe blockage, is a neutral solution, is very small in corrosivity, does not generate intergranular corrosion, is beneficial to protecting various pipes of superheaters and reheaters, and is a safe and efficient superheater cleaning agent.

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and / or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and / or putrescine or related products using the microbial organisms.

The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

The invention discloses application of 2-hydroxybutyric acid and derivatives thereof in preparation of drugs for preventing and / or treating metabolic diseases, and belongs to the technical field of biological medicines. Experiments prove that the 2-hydroxybutyric acid and the derivatives thereof can effectively inhibit obesity induced by high fat diet and reduce body fat, and have good improvement effects on related glucose and lipid metabolism disorders, including reduction of fasting blood-glucose, improvement of glucose tolerance, reduction of liver lipid deposition and improvement of liver functions. More importantly, the 2-hydroxybutyric acid does not affect ingestion, the metabolism improvement effect of the 2-hydroxybutyric acid depends on activation of fat heat production, and energy consumption can be directly promoted, so that obvious gastrointestinal tract adverse reactions cannot be generated, and potential mental side effects of existing appetite inhibiting drugs do not exist.

A method of improving and / or enhancing at least one of bone mineralization, bone strength, bone mass, and bone mineral density in an individual in need thereof, the method comprising administering to the individual a composition comprising one or more anabolic amino acids, and the composition further comprising one or more autophagy-inducing compounds. In one embodiment, the one or more autophagy-inducing compounds are selected from the group consisting of thymol, carvacrol, spermidine, urolithin (e.g., Urolithin A, B or D), rapamycin, Torin1, valproic acid, polyphenols (e.g., resveratrol), caffeine, metformin, 5′ AMP-activated protein kinase (AMPK) activators, L-type calcium channel inhibitors, ketones (e.g. beta-hydroxybutyrate, ketone salts, or ketone ester derivatives), 4,4′-dimethoxychalcone and mixtures thereof.

The invention relates to the field of bio-based composite materials, and discloses a bioplastic-based coupling agent, a modified bamboo fiber, a composite material and a preparation method and application of the bioplastic-based coupling agent and the modified bamboo fiber. The coupling agent is a product obtained by modifying polyhydroxybutyrate valerate and a grafting monomer, and the grafting monomer is at least one of maleic anhydride, acrylic acid or itaconic anhydride. The delignification bamboo powder is modified with the coupling agent, and the modified bamboo fiber, polyhydroxybutyrate-hydroxyvalerate, an initiator and an auxiliary agent are subjected to melt blending to obtain the composite material. The tensile strength and the bending strength of the composite material are respectively improved by 175% and 117%, and the crystallization ability and the thermal stability are also synchronously improved. According to the invention, the unification of high strength, thermal stability and excellent interfacial compatibility is realized while the degradability of the system is maintained, and the composite material has a good green composite material application prospect.

The invention discloses a metabolic biomarker combination for diagnosing depression. The metabolic biomarker combination comprises proline, betaine, alanine, tryptophan, kynurenine, 5-hydroxytryptamine, creatine, succinic acid, taurine and 2-hydroxybutyric acid. Based on a metabolic biomarker combination, an optimal diagnosis model is screened through a machine learning model algorithm, and the kit for depression diagnosis is constructed.

The invention belongs to the technical field of biological medicines, and particularly relates to application of beta-hydroxybutyrate in preparation of a medicine for preventing or treating hepatocellular carcinoma. The invention provides an application of beta-hydroxybutyrate in preparation of a medicine for preventing and / or treating hepatocellular carcinoma. The beta-hydroxybutyrate comprises a beta-hydroxybutyrate or a combination of a plurality of beta-hydroxybutyrates. A series of experimental data show that beta-hydroxybutyrate not only can effectively improve fatty degeneration and inflammatory response of hepatocytes, but also can remarkably reduce the risk of occurrence of metabolic dysfunction related hepatocellular carcinoma (HCC), and can inhibit malignant biological characteristics of HCC. The invention provides a powerful scientific basis for the development of novel HCC prevention and treatment medicines, and has a wide clinical application prospect.

The invention relates to the technical field of polyester degradable plastics, and discloses a biodegradable shrink film as well as a preparation method and application thereof. The preparation method of the biodegradable shrink film comprises the following steps: reacting (R)-3-hydroxybutyric acid with 1, 4-dibromobutane to obtain a dihydric alcohol monomer; the preparation method comprises the following steps: copolymerizing a dihydric alcohol monomer and L-lactide to obtain modified polylactic acid; carrying out copolymerization on the geraniol-based compound and L-lactide to obtain a bio-based plasticizer; modifying the bio-based plasticizer with allyl trimethyl ammonium chloride to obtain a modified bio-based plasticizer; the biodegradable shrink film is prepared by taking modified polylactic acid, poly (butylene adipate-co-terephthalate), a modified bio-based plasticizer, a functional filler and palm wax as raw materials. The biodegradable shrink film has the advantages of flexibility, shrinkage performance, lasting antibacterial performance and good barrier performance, and can be used in food packaging materials.

The invention discloses a method for constructing an engineered bacterium of Clostridium aeruginosa, comprising the following steps: preparing a desired gene in a biosynthetic pathway of a target product, namely a pathway gene, to form a pathway gene cluster; embedding the pathway gene cluster into a transposase recognition site of a mariner transposon to form a pathway gene expression cassette; selecting a constitutive strong promoter commonly used in Clostridium jundal for driving transposase expression, loading the pathway gene expression cassette into a multiple cloning site of a plasmid, and inserting an inducible repressor element upstream of the replicon to obtain a transposition plasmid; transforming the transposition plasmid into Clostridium aeruginosa to obtain an engineered bacterium of Clostridium aeruginosa. The yield of 3-hydroxybutyric acid expressed by the engineered bacterium constructed by the above method is as high as 3g / L.

The invention discloses 3-hydroxybutyric acid betaine salt, which has the following molecular structure: # imgabs0 #, in which Mn < + > is a metal ion selected from Na < + >, K < + >, Mg < 2 + > and Ca < 2 + >; n + is the number of charges and represents 1-2 positive charges. The betaine 3-hydroxybutyrate salt is used as a food additive and a pharmaceutical active ingredient for relieving or preventing fatty liver. The invention also discloses a preparation method of the 3-hydroxybutyric acid betaine salt.