323 results about "Hydroxybutyric acid" patented technology

The invention discloses a pure bio-based polyhydroxyalkanoate adhesive as well as preparation and application thereof, and belongs to the technical field of degradable adhesives. According to the adhesive, polyhydroxybutyrate valerate or polyhydroxybutyrate hexanoate is used as a matrix, and the acid value reaches 2-15 mg KOH / g through molten end group activation; a reactive emulsifier with a hydrophilic-lipophilic balance value of 9-12 is introduced into a water phase, and the stable aqueous dispersion is prepared through phase inversion high-shear emulsification. The Z-average particle size of the dispersion is 0.12-0.30 [mu] m, and the content of the free surfactant is not higher than 30wt%. After the tackifying resin, the plasticizer and the vegetable wax are compounded, the bio-based carbon content of the obtained adhesive is not lower than 95%, and the volatile organic compound content is not higher than 100 mg / kg. The paper / paper heat sealing strength of the adhesive is not lower than 7.0 N / 15mm, the 180-degree peel strength is not lower than 7.5 N / 25mm, and the adhesive can pass repulping evaluation.

The invention provides a recombinant strain for controllably synthesizing high-proportion 4-hydroxybutyric acid (4HB) polyhydroxyalkanoate (PHA) as well as a construction method and application of the recombinant strain. The recombinant strain disclosed by the invention can be used for efficiently producing high-proportion poly (3-hydroxybutyrate-4-hydroxybutyric acid) (P34HB for short) by using glucose as a unique carbon source or a 4HB structure related or non-related carbon source in amplification production of a shake flask, a 7L fermentation tank, a 100L fermentation tank and a 5000L fermentation tank.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The invention provides a bio-based 1, 4-butanediol composition as well as a preparation method and application thereof, and the bio-based 1, 4-butanediol composition comprises bio-based 1, 4-butanediol, 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether. The total mass content of 4-hydroxybutyric acid-(4-hydroxyl) butyl ester and bis (4-hydroxyl) dibutyl ether in the bio-based 1, 4-butanediol composition is 51 to 220 ppm. The bio-based 1, 4-butanediol composition has low hygroscopicity, and can maintain low water content after long-term storage; meanwhile, when the bio-based 1, 4-butanediol composition is used for polyester synthesis, the esterification time can be shortened, the reaction efficiency can be improved, side reactions can be reduced, and a polyester product with better damp-heat resistance stability can be obtained.

Compositions for inducing and maintaining a state of flow in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. The S-beta-hydroxybutyrate enantiomer modulates the effect of ketone bodies in the subject and controls the rate at which ketosis is achieved. Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. Compositions for controlling ketone body level in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and / or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.

The invention provides a composite quality control liquid for an electrochemical multi-parameter detector. The composite quality control liquid comprises a buffer volume, a quality control substance and a stabilizer, the stabilizing agent comprises 5 to 50 g / L of bovine serum albumin, 0.1 to 10 g / L of EDTA-2Na (Ethylene Diamine Tetraacetic Acid), 10 to 100 g / L of a viscosity regulator, 0.3 to 25 g / L of a preservative and 5 to 20 g / L of a surfactant; the preparation method comprises the following steps: adding components of the stabilizer into a buffer system, preparing a preparation solution, preparing mother liquor of each quality control substance, proportionally mixing glucose mother liquor, uric acid mother liquor, beta-hydroxybutyric acid mother liquor and cholesterol sodium sulfate and triglyceride composite mother liquor according to the target concentration of the quality control solution, and fixing the volume by using the preparation solution to obtain the quality control liquid. And fully and uniformly mixing to obtain the composite quality control liquid. The composite quality control liquid can ensure that uric acid is not degraded, cholesterol triglyceride is not separated out, the formula is mild, and active substances in a detection system are not influenced.

The present invention discloses a self-degradable particle temporary plugging agent for fracturing and its preparation method and application, relating to the field of oilfield chemical technology. According to mass percentage, the temporary plugging agent is obtained by melt blending and crushing the materials including the following components: poly (3-hydroxybutyric acid-co-4-hydroxybutyrate), 70%-85%; auxiliary agent for auxiliary degradation, 2%~10%; nano silicon dioxide 10%~15%; sodium starch glycolate, 1%~7%. The temporary plugging agent of the present invention contains disintegrant sodium starch glycolate, which has a strong water absorption capacity and can quickly absorb water and expand its own volume by 250~300 times, so that the temporary plugging agent expands and cracks appear. On the one hand, in the early stage of plugging, the temporary plugging agent can reduce the gap between particles after absorbing water and expanding, thereby increasing the density of the entire plugging layer, thereby improving the plugging ability. On the other hand, cracks are generated on the surface of the temporary plugging agent after expansion, and water can penetrate into the interior of the temporary plugging agent particles from the cracks, which increases the contact area between the temporary plugging agent and water, thereby promoting its degradation and shortening the time of overall degradation.

The invention discloses a composite medical suture and a preparation method thereof, and belongs to the field of biomedicine. In order to solve the problems that an existing medical suture is poor in antibacterial effect and biological safety, the composite medical suture comprises a core layer, a degradation regulation and control layer, a slow release layer and an antibacterial layer which are sequentially arranged from inside to outside; the core layer is prepared from a blend fiber of poly (hydroxybutyrate-hydroxyvalerate) and polycaprolactone-co-polyglycolide; the degradation regulation and control layer comprises a mixture of at least two kinds of polyethylene glycol with different molecular weights; the slow release layer comprises quaternary ammonium salt loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. Through the synergistic effect of the four layers, the comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function is realized; the purposes of improving the slow-release antibacterial performance, reducing damage to the human body, reducing inflammation and the like are achieved, and the antibacterial and degradation effects meet the recovery requirements.

The invention discloses a neutral organic chelating cleaning agent for a boiler, and belongs to the field of chemical cleaning of boiler superheaters of thermal power plants. The cleaning agent is prepared from the following components in percentage by weight: 0.5%-5% of ethylenediamine tetraacetic acid ammonium, 0.1%-4% of acetic acid or ammonium acetate, 0.1%-3% of glycollic acid ammonium or glycollic acid, 0.1%-5% of a pH regulator, 0.1%-1% of a cosolvent, 0.2%-0.8% of a corrosion inhibitor SH369, 0.1%-0.6% of a reducing agent, 0.0%-0.3% of a defoaming agent, 0.0%-0.2% of a surfactant and 84%-93% of water, wherein the pH value of the cleaning agent is 6-8; the cosolvent is tartaric acid and / or hydroxybutyl diacid, the surfactant is nonylphenol polyoxyethylene ether, and the reducing agent is hydrazine. The cleaning agent disclosed by the invention has good dissolving capacity on oxide skin, does not generate precipitates to cause pipe blockage, is a neutral solution, is very small in corrosivity, does not generate intergranular corrosion, is beneficial to protecting various pipes of superheaters and reheaters, and is a safe and efficient superheater cleaning agent.

The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

The invention relates to the field of bio-based composite materials, and discloses a bioplastic-based coupling agent, a modified bamboo fiber, a composite material and a preparation method and application of the bioplastic-based coupling agent and the modified bamboo fiber. The coupling agent is a product obtained by modifying polyhydroxybutyrate valerate and a grafting monomer, and the grafting monomer is at least one of maleic anhydride, acrylic acid or itaconic anhydride. The delignification bamboo powder is modified with the coupling agent, and the modified bamboo fiber, polyhydroxybutyrate-hydroxyvalerate, an initiator and an auxiliary agent are subjected to melt blending to obtain the composite material. The tensile strength and the bending strength of the composite material are respectively improved by 175% and 117%, and the crystallization ability and the thermal stability are also synchronously improved. According to the invention, the unification of high strength, thermal stability and excellent interfacial compatibility is realized while the degradability of the system is maintained, and the composite material has a good green composite material application prospect.

The invention belongs to the technical field of biological medicines, and particularly relates to application of beta-hydroxybutyrate in preparation of a medicine for preventing or treating hepatocellular carcinoma. The invention provides an application of beta-hydroxybutyrate in preparation of a medicine for preventing and / or treating hepatocellular carcinoma. The beta-hydroxybutyrate comprises a beta-hydroxybutyrate or a combination of a plurality of beta-hydroxybutyrates. A series of experimental data show that beta-hydroxybutyrate not only can effectively improve fatty degeneration and inflammatory response of hepatocytes, but also can remarkably reduce the risk of occurrence of metabolic dysfunction related hepatocellular carcinoma (HCC), and can inhibit malignant biological characteristics of HCC. The invention provides a powerful scientific basis for the development of novel HCC prevention and treatment medicines, and has a wide clinical application prospect.

The invention relates to the technical field of polyester degradable plastics, and discloses a biodegradable shrink film as well as a preparation method and application thereof. The preparation method of the biodegradable shrink film comprises the following steps: reacting (R)-3-hydroxybutyric acid with 1, 4-dibromobutane to obtain a dihydric alcohol monomer; the preparation method comprises the following steps: copolymerizing a dihydric alcohol monomer and L-lactide to obtain modified polylactic acid; carrying out copolymerization on the geraniol-based compound and L-lactide to obtain a bio-based plasticizer; modifying the bio-based plasticizer with allyl trimethyl ammonium chloride to obtain a modified bio-based plasticizer; the biodegradable shrink film is prepared by taking modified polylactic acid, poly (butylene adipate-co-terephthalate), a modified bio-based plasticizer, a functional filler and palm wax as raw materials. The biodegradable shrink film has the advantages of flexibility, shrinkage performance, lasting antibacterial performance and good barrier performance, and can be used in food packaging materials.

The invention discloses piezoelectric electrospinning rod compounded collagen-based hydrogel as well as a preparation method and application thereof, and belongs to the field of piezoelectric biological materials. Carrying out electrospinning on polyhydroxybutyrate through an electrospinning technology to prepare piezoelectric oriented fibers loaded with piezoelectric ceramics; preparing the piezoelectric oriented fiber into a piezoelectric electrospinning rod by using a freezing slicing technology; collagen and chitosan are cross-linked by using a biological cross-linking agent to form collagen-based hydrogel; and compounding the piezoelectric electrospinning rod in the collagen-based hydrogel to prepare the collagen-based hydrogel compounded by the piezoelectric electrospinning rod. The hydrogel prepared by the invention has good piezoelectric property, better mechanical property and excellent biocompatibility, and can well meet the requirement of an endogenous electric field at a cartilage defect.

The invention provides a degradable plastic bag material and a preparation method thereof, and belongs to the field of plastic bag materials. The degradable plastic bag material is prepared from the following chemical components: 40 to 50 parts of polylactic acid, 15 to 25 parts of 3-hydroxybutyrate-co-4-hydroxybutyric acid copolymer, 5 to 15 parts of silane coupling agent modified starch, 3 to 8 parts of acetylated bamboo source nano cellulose, 5 to 15 parts of furan-terminated polylactic acid copolymer, 3 to 8 parts of bismaleimide dodecanedioate, 2 to 6 parts of coffee residue loaded WO3 and TiO2 and 1 to 5 parts of epoxidized soybean oil, the composition comprises the following components in parts by weight: 1-3 parts of sodium alginate microencapsulated lipase, 1-3 parts of quaternary ammonium salt modified hydrophilic kaolin, 0.1-1 part of zinc phenylphosphate and 0.1-0.8 part of polycarbodiimide. According to the application, the balance between the mechanical property and the degradation rate of the plastic bag material is realized through light-enzyme synergistic trigger degradation and dynamic covalent network regulation and control.

The invention relates to the technical field of surface treatment, in particular to a bio-based degradable cable material and a preparation method thereof. The bio-based degradable cable material is prepared from 55 to 65 parts of matrix resin mixed by poly L-lactic acid and poly-3-hydroxybutyrate-3-hydroxyhexanoate, 4 to 6 parts of dianhydride modified castor oil polyol, 10 to 15 parts of polypentamethylene diamine adipate, 5 to 8 parts of nano reinforcing filler, 6 to 10 parts of bio-based plasticizer, 0.5 to 1.0 part of antioxidant and 8 to 12 parts of environment-friendly flame retardant. A dynamic ester bond cross-linked network formed by the reaction of a dynamic ester bond cross-linking agent dianhydride modified castor oil polyol only undergoes ester bond breakage at a high temperature exceeding a normal working range to release stress, and the temperature returns to normal and can be recombined; the semi-interpenetrating network reinforced phase poly (pentamethylene diamine adipate) and the matrix resin form an interpenetrating structure in a molecular chain interpenetrating manner, a stable heat-resistant skeleton is constructed, high-temperature deformation is effectively inhibited, the overall degradability of the material is ensured by the bio-based structure, and the balance of heat resistance and degradability is realized.

Disclosed in the present invention are a strain for producing 3-hydroxybutyric acid, a construction method therefor, and the use thereof. The construction method comprises the following steps: S1, amplifying sequences of phaA, phaB and tesB genes in vitro, linking the sequences of the genes into a single fragment, and introducing the single fragment into a plasmid; and S2, introducing the plasmid obtained in the step S1 into a strain. The present invention uses an engineered strain for fermentation to produce 3-HB; by means of further improving a combined metabolic pathway, and adding sodium salt of a short-chain fatty acid during fermentation as a substrate, the present invention reduces the influence of intermediate metabolite acetic acid on the yield of 3-HB of the strain, thereby further improving the 3-HB yield. In addition, the present invention involves a simple production process, achieves high production efficiency, and is suitable for continuous industrial production.

A method of improving flavor of a combination of a composition for increasing circulating ketone levels is disclosed. A composition containing (D)-β-hydroxybutyric acid (D-BHB), (D)-β-hydroxyvaleric acid (D-BHV), and (D)-1,3 butanediol (D-1,3BD) is disclosed. Exemplary compositions may be incorporated into food, supplement, and beverage products.

A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.

The invention relates to the technical field of environment-friendly materials, and discloses an environment-friendly plastic bag which is of a three-layer composite structure composed of the following raw materials in parts by weight: an outer layer, 60-80 parts of polylactic acid, 40-60 parts of poly (adipic acid) or butylene terephthalate with a thickness ratio of 40%, and a middle layer, 75-90 parts of modified cassava starch, 25-35 parts of polyvinyl alcohol and 3-8 parts of a citrate cross-linking agent with a thickness ratio of 30%. The inner layer comprises 80-95 parts of polyhydroxybutyrate valerate and 15-25 parts of surface treatment calcium carbonate, the thickness ratio of the inner layer is 30%, the three layers are integrally formed through a co-extrusion film blowing process, and a micron-sized groove array is arranged on the surface of the outer layer. The outer layer adopts the blend of polylactic acid and dibutyl phthalate, the brittleness of polylactic acid is made up by utilizing the flexibility of dibutyl phthalate, and meanwhile, the use amount of pure polylactic acid is reduced, so that the cost is reduced by 40% compared with that of a pure polylactic acid bag; and 15 wt% of stearic acid is added into the inner layer polyhydroxybutyrate valerate to treat calcium carbonate, so that the performance is ensured, and the cost is controlled at the same time.

This invention belongs to the field of biomedicine and specifically relates to the use of β-hydroxybutyrate in the preparation of a drug for the treatment of endometriosis. In animal experiments, BHB treatment significantly reduced endometriosis lesions between days 4 to 18 and 28 after modeling. Clinical studies have also found decreased serum BHB levels in endometriosis patients, suggesting that BHB supplementation may improve endometriosis symptoms. This suggests that BHB has a beneficial therapeutic effect on endometriosis and holds promise for clinical application.

The invention provides a method for preparing (R)-4-chloro-3-hydroxybutyric acid ethyl ester ((R)-CHBE) through enzyme catalysis, which comprises the following steps: isopropanol is used as a hydrogen donor, a ketoreductase mutant is used for carrying out catalytic reduction reaction of COBE to prepare (R)-CHBE, and the ketoreductase mutant has amino acid mutation at the 83rd site on the basis of an amino acid sequence shown as SEQ ID NO.1. The invention also provides a preparation method of (R)-4-chloro-3-hydroxybutyric acid ethyl ester ((R)-CHBE). The thermal stability, namely heat resistance, of the ketoreductase mutant is improved, and by combining with the use of a rectifying tower, the method disclosed by the invention improves the utilization rate of isopropanol and can discharge a byproduct acetone in time, so that the substrate conversion rate and the product concentration are improved. The invention also provides an enzyme catalysis device used in the method.

The invention discloses a method for preparing D-3-hydroxybutyric acid, which comprises the following steps: adding D-3-hydroxybutyrate into a food-grade sodium hydroxide aqueous solution with the concentration of not higher than 1.2 M, and stirring at the temperature of not higher than 45 DEG C to carry out hydrolysis reaction until the hydrolysis is finished to obtain a sodium D-3-hydroxybutyrate aqueous solution; in the D-3-sodium hydroxybutyrate aqueous solution, controlling the temperature to be not higher than 45 DEG C, adding food-grade hydrochloric acid which is equivalent to sodium hydroxide, and carrying out neutralization reaction, so as to obtain a D-3-hydroxybutyric acid aqueous solution; and carrying out reduced pressure distillation on the reaction liquid until crystallization, cooling to 5 DEG C, growing the crystal, separating, and drying to obtain the D-3-hydroxybutyric acid crystal. The invention also discloses ketogenic effervescent tablets containing D-3-hydroxybutyric acid as an active component and a preparation method thereof.

The present invention relates to a recombinant organism or microorganism having a decreased pool of crotonic acid compared to the organism or microorganism from which it is derived due to at least one of: (i) an increased conversion of crotonyl-CoA into butyryl-CoA; and / or an increased conversion of butyryl-CoA into butyric acid; (ii) an increased conversion of crotonyl-CoA into 3-hydroxybutyryl-CoA; and / or an increased conversion of 3-hydroxybutyryl-CoA into 3-hydroxybutyric acid; (iii) an increased conversion of crotonic acid into crotonyl-CoA; (iv) an increased conversion of crotonyl-[acyl-carrier protein] into butyryl [acyl-carrier-protein]; (v) a decreased conversion of crotonyl-CoA into crotonic acid; and / or (vi) a decreased conversion of crotonyl-[acyl-carrier protein] into crotonic acid. Moreover, the present invention relates to the use of such a recombinant organism or microorganism for the production of alkenes with the enzyme ferulic acid decarboxylase. Further, the present invention relates to a method for the production of isobutene or butadiene by culturing such a recombinant organism or microorganism in a suitable culture medium under suitable conditions.

The present application relates to the technical field of surface treatment, in particular to a kind of biobased degradable cable material and preparation method thereof.Biobased degradable cable material includes 55-65 parts of poly-L-lactic acid and poly-3-hydroxybutyric acid-3-hydroxyhexanoate mixed matrix resin, 4-6 parts of dianhydride modified castor oil polyol, 10-15 parts of polyaminoval, 5-8 parts of nano enhanced filler, 6-10 parts of biobased plasticizer, 0.5-1.0 parts of antioxidant, 8-12 parts of environmentally friendly flame retardant.Dynamic ester bond crosslinking agent dianhydride modified castor oil polyol reaction forms dynamic ester bond crosslinking network, ester bond breakage occurs at high temperature beyond normal working range to release stress, temperature returns to normal and can recombine again;Semi-interpenetrating network enhanced phase polyaminoval forms interpenetrating structure with matrix resin in molecular chain interlacing mode, constructs stable heat-resistant skeleton, effectively inhibits high-temperature deformation, and its biobased structure ensures the overall degradability of the material, realizes the balance of heat resistance and degradability.

The invention provides a metabolic marker for auxiliary diagnosis of schizophrenia, a construction method and application. Wherein the metabolic marker comprises lysophosphatidylcholine (LPC) (17: 0 / 0: 0), oleamide, lysophosphatidyl ethanolamine LysoPE (18: 0 / 0: 0), palmitamide, lysophosphatidyl ethanolamine LysoPE (0: 0 / 20: 4), lysophosphatidyl ethanolamine LysoPE (22: 6 / 0: 0), p-methylphenol sulfate, lactic acid, 3-hydroxybutyric acid, lysophosphatidyl ethanolamine LysoPE (18: 2 / 0: 0), lysophosphatidyl ethanolamine LysoPE (16: 0 / 0: 0) and sphingosine 1-phosphate. By utilizing the metabolic marker, auxiliary diagnosis of schizophrenia can be rapidly and accurately completed in the early stage of disease attack.

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

Compositions and methods for providing a person with an exogenous and therapeutically effective supply of short chain fatty acids, chlorogenic acid, and, optionally, ketones are disclosed. The compositions include one or more short chain fatty acids (such as butyric acid, butyrate salts, propionic acid, propionate salts, acetic acid, or acetate salts); chlorogenic acid; and, optionally, one or more beta-hydroxybutyrate salts. The compositions and methods are useful for inducing ketosis and / or beta-oxidative activity in a subject. In addition, compositions that include concentrated forms of, and methods of using, chlorogenic acid (alone or in combination with short chain fatty acids and ketones) to induce ketogenesis in a subject are disclosed.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.