39 results about "3-Hydroxypentanoic acid" patented technology

Several novel PHA polymer compositions produced using biological systems include monomers such as 3-hydroxybutyrate, 3-hydroxypropionate, 2-hydroxybutyrate, 3-hydroxyvalerate, 4-hydroxybutyrate, 4-hydroxyvalerate and 5-hydroxyvalerate. These PHA compositions can readily be extended to incorporate additional monomers including, for example, 3-hydroxyhexanoate, 4-hydroxyhexanoate, 6-hydroxyhexanoate or other longer chain 3-hydroxyacids containing seven or more carbons. This can be accomplished by taking natural PHA producers and mutating through chemical or transposon mutagenesis to delete or inactivate genes encoding undesirable activities. Alternatively, the strains can be genetically engineered to express only those enzymes required for the production of the desired polymer composition. Methods for genetically engineering PHA producing microbes are widely known in the art (Huisman and Madison, 1998, Microbiology and Molecular Biology Reviews, 63: 21-53). These polymers have a variety of uses in medical, industrial and other commercial areas.

The present invention provides a card base which is degradable by microbes in natural environment. The card base is excellent in properties necessary for card bases, such as tensile strength, impact strength, flex temperature, heat resistance, resistance to thermal expansion and contraction, blocking resistance and humidity resistance, and has rigidity, bending resistance and durability. The card base contains, as essential components, a 3-hydroxybutylate/3-hydroxyvalerate copolymer and a lactic acid polymer, and, where necessary, a polycaprolactone or a high-molecular aliphatic polyester. The card base has a single-layer structure, or a sandwich structure further having overlay layers comprising a composition containing, as essential components, a lactic acid polymer and either or both of a polycaprolactone and a high-molecular alphatic polyester.

The invention discloses resource-renewable and biodegradable conductive fiber and a preparation method thereof. The fiber consists of the following raw materials in parts by weight: 30-70 parts of polylactic acid (PLA), 30-70 parts of poly(3-hydroxybutyric acid-co-3-hydroxyvalerate (PHBV) and 0.05-8 parts of conductive filler. The preparation method of the conductive fiber comprises the following steps of: (1) proportionally pre-mixing PHBV (if PLA is not less than 50 parts) or PLA (if PLA is less than 50 parts) and the conductive filler, and performing melt blending and granulation to obtain the conductive master batch of the PHBV or PLA; (2) proportionally pre-mixing the PLA or PHBV and the conductive master batch of the PHBV or PLA, and performing melt blending and granulation to obtain composite conductive mater batches; and (3) spinning and drafting the composite conductive master batches one by one to obtain the conductive fiber. The conductive fiber disclosed by the invention can be used as the material for electrodes, static resistance, low-temperature heating, electromagnetic shielding, thermal sensitivity, gas sensitivity and the like.

The invention discloses a functional PET technology, and particularly relates to a poly 3-hydroxybutyrate-3-hydroxyvalerate and poly lactic acid blending modification polyester filament and a preparation method thereof. The invention aims at overcoming the defects in the prior art and providing a PLA (Poly Lactic Acid) and PHBV (Poly Hydroxyl Butyrate Valerate) blending modification polyester filament which is quick in degradation velocity, high in softness, good in handfeel, and easy to color and a preparation method thereof. The polyester filament consists of 20-50wt% of PLA and the balance of PHBV, can satisfy the existing pursue of people, and has the characteristics that under the condition that the quality of cloth is met, abundant colors can be selected by people, so that the more choices are provided.

The invention relates to a method for preparing a high-toughness degradable material by using a melt-grafting blending method, which comprises the following steps: (1) carrying out melt-grafting on polycaprolactone PCL, anhydride and an initiator, and then obtaining modified polycaprolactone by way of extrusion granulation, wherein the mass ratio of the polycaprolactone PCL to the anhydride to the initiator is 100: (1 to 10): 0.5; and (2) carrying out melt-grafting blending on poly (3-hydroxybutyrate-3-hydroxyvalerate) PHBV, the modified polycaprolactone, methyl acrylate and an initiator, and then obtaining the high-toughness PHBV-class degradable material by way of extrusion granulation, wherein the mass ratio of the poly (3-hydroxybutyrate-3-hydroxyvalerate) PHBV to the modified polycaprolactone to the methyl acrylate to the initiator is 100: (5 to 50): (0.5 to 10):0.5, the processing temperature is 100 to 170 DEG C, and the screw speed is 50-80 R.P.M. The method is simple in process, low in cost, and suitable for industrialization, and the elongation at break of the produced PHBV-class degradable material can reach 560 percent; therefore, the method of the invention has good application prospect.

The invention discloses construction and application of a polygene knockout strain of Halomonas sp. TD01. The invention provides a recombinant strain which is obtained by inactivating one or more genes related to metabolic pathways of propionic acid in the Halomonas sp. TD01 used for producing polyhydroxyalkanoate (PHA). The one or more genes related to metabolic pathways of propionic acid are at least one selected from the group consisting of a coding gene for 2-methylcitrate synthetase, a coding gene for PHA digestive enzyme 1, a coding gene for PHA digestive enzyme 2 and a coding gene for PHA digestive enzyme 3. According to results of experiments in the invention, molecular modification is carried out on the Halomonas sp. TD01 to knock out 2-methylcitrate synthetase PrpC and three PHA digestive enzymes so as to obtain the novel recombinant strain, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with more excellent material performance can be highly efficiently produced by utilizing propionic acid, and the proportion of 3-hydroxyvaleric acid monomers in the produced PHBV and the conversion rate of the substrate propionic acid are substantially improved.

The present invention relates to a method of producing polyhydroxyalkanoates (PHAs) using Bacillus sp. with succinate as a carbon source. The PHAs comprise more than 95% of poly(3-hydroxyvalerate-co-4-hydroxyvalerate) (P3HV-co-P4HV).

The invention discloses a bio-based compatilizer, a preparation method and the application thereof. The preparation method comprises the following steps of: respectively alcohol depolymerization on poly3-hydroxy-butanoic acid ester (PHB), poly3-hydroxy-butanoic acid ester-3- hydroxyvalerate (PHBV), polylactic acid (PLA) and polybutylene succinate (PBS) to obtain 4 alcohol depolymerized products; and then reactively blending more than 2 products, certain amount of isocyanate and antioxidant for reacting to obtain different bio-based compatilizers. 2-20 parts of compatilizers are added into 10 parts of bio-based resin to prepare a composite material, which obviously improves the compatibility of system interface, greatly improves the overall properties and widens the application link of the bio-based resin. The composite material can be widely applied to the production or consume fields of automobile trims, stationery products, traffic road blocks, sport products, food bags, refuge bags, disposable table cloth, outdoor flower pots, lunch boxes, knives and forks and the like.

The invention discloses a poly-3-hydroxy propionic acid copolymer and a production method thereof and belongs to the technical field of genetic engineering. According to the poly-3-hydroxy propionic acid copolymer and the production method thereof, a glycerol dehydratase gene and a glycerol dehydratase re-activating enzyme gene are integrated with a host strain genome by a gene integration technology, a polyhydroxy fatty acid synthase gene, a propionaldehyde dehydrogenase gene, a beta-ketoacyl coenzyme A thiolase gene, an acetoacetyl coenzyme A reductase gene and a propionyl coenzyme A synthetase gene are introduced, and a recombinant gene engineering strain has the ability of biologically synthesizing poly-3-hydracrylic acid-co-3-hydroxyvaleric acid. According to the poly-3-hydroxy propionic acid copolymer and the production method thereof, the poly-3-hydracrylic acid-co-3-hydroxyvaleric acid is obtained in a biosynthesis manner for the first time; compared with poly-3-hydracrylic acid, the obtained poly 3-hydracrylic acid-co-3-hydroxyvaleric acid has a higher melting point and lower crystallinity, has good degradability and can serve as a packaging material, a medical implant material, a drug sustained-release material and an electrochemical material.

The invention discloses a PHBV (polyhydroxylbutyrate valerate) polymer, a preparation method and a hemostatic material manufactured by using the PHBV polymer. The PHBV polymer is a copolymer of 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3HV), and the main chain of the polymer includes at least 50 blocks of poly 3-hydroxybutyrate and at least 50 blocks of poly 3-hydroxyvalerate. The preparation method comprises: inoculating Haloferax mediterranei ES1 strains to a fermentation medium, and automatically feeding 2M hydrochloric acid solution or 2M sodium hydroxide solution under the condition that the fermentation temperature is 37 DEG C, the stirring revolution speed is 300-500r/min and the ventilatory capacity is 1.25: 1vvm to stabilize the pH value at 6.9-7.1; fermenting for 36-48h under the condition that the ventilatory capacity is 1.25: 1vvm and the inner pressure of a tank body is 1 atmosphere; and extracting the PHBV polymer from the fermentation solution.

This invention relates to a process for the preparation of a 3-hydroxycarboxylic acid from a 3-hydroxynitrile. More specifically, 3-hydroxyvaleronitrile is converted to 3-hydroxyvaleric acid in high yield at up to 100% conversion, using as an enzyme catalyst 1) nitrile hydratase activity and amidase activity or 2) nitrilase activity of a microbial cell. 3-Hydroxyvaleric acid is used as a substitute for ε-caprolactone in the preparation of highly branched copolyester.

The invention relates to a synthetic route and a method for preparing (R)-5-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylamino formyl-1H-pyrrole-1-ethyl)-3-hydroxyvalerate. The (R)-5-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylamino formyl-1H-pyrrole-1-ethyl)-3-hydroxyvalerate is obtained through seven steps by using (R)-2,3-dihydroxy-chloropropane as raw material. The method provided bythe invention has low cost, simple operation, and is suitable for industrialization.

The invention belongs to the field of pharmaceutical chemistry, and provides a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor. The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor is a polysubstituted indole statin fluorine-containing modifier of 1-fluoro-3-hydroxypentanoic acid and its salt or ester formed after ring opening of 3-fluoro-caprolactone fragment and its lactone. The structural formula of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor is shown in the specification. A result of test of like compounds shows that the compounds have an HMG-CoA reductase activity inhibition effect, and can be used as a new-generation latent HMG-CoA reductase inhibitor.

The present invention belongs to the field of pharmaceutical chemistry, and provides 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, wherein a fragment containing 3-fluoro-caprolactone and a lactone thereof are subjected to ring opening to form a poly-substituted pyrimidine statin fluorine-containing modifier of 1-fluoro-3-hydroxy-pentanoic acid and a salt or ester thereof, ie., the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, and the structure formula is defined in the specification. According to the present invention, the test results show that the compounds have the HMG-CoA reductase activity inhibition effects, and can be used as the new generation of the potential HMG-CoA reductase inhibitors.

The invention relates to the technical field of organic compound synthesis and application and in particular relates to a preparation method of 2,2,4-trimethyl-3 methoxy ethyl hydroxyvalerate and a water-borne wood lacquer and a preparation method thereof. The preparation method of the 2,2,4-trimethyl-3 methoxy ethyl hydroxyvalerate comprises the following steps: 1) performing a hydroxyaldehyde condensation reaction on iso-butyraldehyde under the action of an alkaline catalyst so as to generate produces 2,2,4-trimethyl-3-hydroxyentanaldehyde, and performing an oxidation reaction on the obtained 2,2,4-trimethyl-3-hydroxyentanaldehyde with H2O2 so as to obtain 2,2,4-trimethyl-3 hydroxypentanoic acid; and 2) enabling the 2,2,4-trimethyl-3 hydroxypentanoic acid prepared in the step 1) to reactwith ethylene glycol monomethyl ether under the action of a strong acid catalyst, so as to obtain the 2,2,4-trimethyl-3 methoxy ethyl hydroxyvalerate. The preparation method of the 2,2,4-trimethyl-3methoxy ethyl hydroxyvalerate, which is provided by the invention, is single in reaction product, needs no multi-step separation and is simple to operate. Meanwhile, the invention further provides thewater-based wood lacquer and the preparation method thereof.