Composite porous calcium phosphate bone cement and method for making same

A technology of calcium phosphate bone cement and porous calcium phosphate, which is applied in the fields of medical science and prostheses, can solve the problems of slow degradation and low strength, and achieve the effect of promoting degradation, fast degradation and promoting reconstruction

Inactive Publication Date: 2009-09-09
TSINGHUA UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a composite porous calcium phosphate bone cement and a preparation method thereof in order to overcome the disadvantages of low strength and slow degradation rate of the previous porous calcium phosphate bone cement

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] The preparation method of the present invention comprises the following steps:

[0029] (1) Prepare calcium phosphate bone cement solid phase powder (the known calcium phosphate bone cement has many kinds and can be used, and its preparation method is known technology, for example a kind of specific preparation method of calcium phosphate bone cement solid phase powder is: α Type tricalcium phosphate, calcium dihydrogen phosphate and calcium carbonate powder in molar ratio: α-type tricalcium phosphate / dicalcium phosphate / calcium carbonate=(8~12) / (1~2) / (3~5) without mixed by ball milling in water-ethanol medium, and dried at 80-100°C);

[0030] (2) Prepare simulated body fluid: add 8.00-24.00 grams of sodium chloride, 0.35-1.01 grams of sodium bicarbonate, 0.23-0.69 grams of potassium chloride, and 0.23-0.69 grams of dipotassium hydrogen phosphate in 1000 milliliters of deionized water or distilled water. 0.31-0.93 grams of magnesium chloride, 0.28-0.84 grams of calcium...

Embodiment 1

[0040] (1) Mix α-type tricalcium phosphate, calcium dihydrogen phosphate and calcium carbonate powder in molar ratio:

[0041] α-type tricalcium phosphate: calcium dihydrogen phosphate: calcium carbonate = 8:1:3, ball milling and mixing in absolute ethanol medium, drying at 80°C, to prepare calcium phosphate bone cement solid phase powder;

[0042] (2) Add 12 grams of sodium chloride, 0.53 grams of sodium bicarbonate, 0.34 grams of potassium chloride, 0.34 grams of dipotassium hydrogen phosphate, 0.46 grams of magnesium chloride, 0.42 grams of calcium chloride, and sodium sulfate in 1000 milliliters of deionized water or distilled water. 0.1 g, Tris 9.09, prepare simulated body fluid, and adjust the pH value of the simulated body fluid to 7.2 with 1 molar hydrochloric acid solution;

[0043] (3) PHBV microspheres were dosed with Co 60 gamma rays for irradiation treatment;

[0044] (4) Wash and dry the PHBV microspheres after (3) irradiation treatment with deionized water, pl...

Embodiment 2

[0052] (1) Mix α-type tricalcium phosphate, calcium hydrogen phosphate, tetracalcium phosphate and calcium carbonate powder in molar ratio:

[0053] α-type tricalcium phosphate: calcium hydrogen phosphate: tetracalcium phosphate: calcium carbonate=10:1:1.5:3 ball milling and mixing in absolute ethanol medium, drying at 80°C to prepare calcium phosphate bone cement solid phase powder;

[0054] (2) Add 8.00 grams of sodium chloride, 0.35 grams of sodium bicarbonate, 0.23 grams of potassium chloride, 0.23 grams of dipotassium hydrogen phosphate, 0.31 grams of magnesium chloride, 0.28 grams of calcium chloride, and 0.28 grams of calcium chloride in 1000 milliliters of deionized water or distilled water. Sodium 0.07 gram, Tris 6.06 gram, preparation simulated body fluid, and the pH value of simulated body fluid is adjusted to 7.3 with the hydrochloric acid solution of 1 molar concentration;

[0055] (3) PHBV microspheres were dosed with Co 60 gamma rays for irradiation treatment; ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
compressive strengthaaaaaaaaaa
Login to view more

Abstract

The invention relates to a composite porous calcium phosphate bone cement and a preparation method thereof, belonging to the technical field of calcium phosphate bone cement preparation. The phosphorus bone cement is composed of calcium phosphate bone cement solid phase powder, 3-hydroxybutyric acid-CO-3-hydroxyvaleric acid copolymer microspheres irradiated with Co60 gamma rays and a solidification solution; the method is to prepare calcium phosphate Bone cement solid phase powder; preparation of simulated body fluid: PHBV microspheres are irradiated with Co60γ rays, washed and dried in water, completely immersed in simulated body fluid, and then washed and dried; then PHBV microspheres are mixed with calcium phosphate bone cement solid phase After powder mixing, compound bone cement slurry is prepared with curing liquid. The composite bone cement of the present invention has high initial curing strength, rapid degradation in the later stage of implantation, and the degradation speed can be adjusted, and the porous structure formed after degradation is beneficial to the growth of new bone tissue and the reconstruction of autogenous bone. It is mainly used for bone defect repair and bone tissue engineering scaffold materials, and can also be used as dental repair materials.

Description

technical field [0001] The invention belongs to the technical field of calcium phosphate bone cement composite materials, in particular to a composite calcium phosphate bone cement composite material capable of degrading in vivo to form pores and a preparation method thereof. Background technique [0002] Self-curing calcium phosphate bone cement has in-situ curing at room temperature or human physiological environment temperature, the structure and composition of the cured body are similar to the structure and composition of natural bone mineral phase, it can be shaped arbitrarily during surgery, and can fill bone defects of various shapes, etc. It can be widely used in clinical fields such as fracture fixation, bone defect repair, dental and maxillofacial surgery repair, and drug carrier. It is a research hotspot in the field of bone repair and hard tissue replacement materials. [0003] Although the ordinary calcium phosphate bone cement material also has a certain porosi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/58A61L27/56
Inventor 董利民王晨昝青峰刘海兰李兆新田杰谟
Owner TSINGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap