88 results about "Tetracalcium phosphate" patented technology

A dentin mineralizing agent comprising tetracalcium phosphate particles (A) and an alkali metal salt of phosphoric acid (B), wherein the dentin mineralizing agent contains the tetracalcium phosphate particles (A) in an amount of 1 to 80 parts by weight relative to 100 parts by weight of the whole amount of the dentin mineralizing agent, and the blended amount of the alkali metal salt of phosphoric acid (B) relative to 100 parts by weight of the tetracalcium phosphate particles (A) is 1 to 100 parts by weight. Thus is provided a dentin mineralizing agent by which a dense HAp is formed on a dentin surface and HAp is deposited to a deep portion of a dentinal tubule, so that it can close the dentinal tubule.

The invention relates to injectable bone cement containing strontium and a preparation method of the injectable bone cement. The injectable bone cement comprises solid phase and liquid phrase, wherein the solid phrase comprises polymethylmethacrylate, calcium sulfate hemihydrate, tetracalcium phosphate, strontium hydrogenphosphate, barium sulfate and benzoyl peroxide; the liquid phrase comprises a methyl methacrylate monomer, N,N dimethyl paratoluidine and hydroquinone; the preparation method of the injectable bone cement comprises the following steps: mixing solids and liquids at a mass ratio of 2 to 1; stirring uniformly by using a bone cement mixing and stirring system; using an injecting system to inject the bone cement; in the injectable bone cement containing the strontium, the calcium sulfate hemihydrate, the tetracalcium phosphate and the strontium hydrogenphosphate are distributed uniformly; after the injectable bone cement is implanted into a body, calcium ions and strontium ions are degraded and released gradually in the body to form a honeycomb structure and guide cells to ingrow, so that joint connection is formed so as to prevent looseness; the compressive strength of the prepared injectable bone cement containning the strontium are higher than 50 MPa. The injectable bone cement containing the strontium can be used in fracture fixation caused by osteoporosis and the like and bone defect filling.

The invention discloses a method for preparing tetracalcium phosphate by using natural bone powder in biomedical material technical field, comprising following steps: firstly, weighting and mixing the natural bone powder and calcium carbonate powder, the molar ratio of calcium and phosphor being two to two point one, adding the distilled water and mixing up in order to get HAP-CaCO3 suspension, stirring fully until two kinds of powder are mixed evenly and contact completely, putting into an oven and drying, taking out the dried powder, grinding and sieving; secondly, putting the powder into a sintering furnace to calcine at the temperature of one thousand and four hundred DEG C to one thousand and five hundred DEG C, preserving the heat for hours, taking out and cooling in order to get tetracalcium phosphate. The invention has the advantages of using aninial bone powder as raw mateiral, and having simple preparation craft, controllable parameter and high purity of the products obtained.

A calcium phosphate composition comprising tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B) and at least one kind of inorganic particles (C) selected from silica particles or titania particles, wherein the mixing ratio (A/B) of (A) to (B) is from 45/55 to 55/45 in molar ratio, the inorganic particles (C) have an average particle diameter of from 0.002 to 0.5 μm, and the inorganic particles (C) are contained in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of (A) and (B) in total. Thereby provided is a calcium phosphate composition such that when it is used as a material for bone repair, a formed bone has high mechanical strength and a high bone replacement rate is achieved.

The invention discloses an active polysaccharide composite bone repair material which is good in biocompatibility, good in plasticity, certain in mechanical strength and moderate in degradation velocity in bodies and can meet clinical requirements. The active polysaccharide composite bone repair material comprises a bottle A and a bottle B, wherein the bottle A comprises powder of tetracalcium phosphate, calcium hydrophosphate, chitosan, monosodium phosphate and hydroxypropyl methylcellulose; the bottle B comprises mannitol, an MES solution and a rhBMP-2 biological active factor freeze-dried aquatic product. The active polysaccharide composite bone repair material can induce formation of new bone in a human body, can form active tissue, has the advantages of good compatibility, plasticity and the like, is free of toxic reaction and can be tightly connected with sclerotin after being cured.

The method relates to the production of essentially pyrogene-free calcium phosphate starting from one or more calcium phosphate educts having a Ca/P molar ratio in the range of 1.00 to 2.00 and being formed in a pre-determined shape which remains essentially the same during the following procedural steps: A) transforming said educt(s) at least partly to beta-tricalcium phosphate (α-TCP), alpha-tricalcium phosphate (α-TCP), tetracalciumphosphate.(TetCP) or a mixture thereof at a temperature above 600° C.; B) cooling down the material obtained in step A with said β-TCP, α-TCP, TetCP or a mixture thereof to below 600° C.; C) reacting the material obtained in step B with said β-TCP, α-TCP, TetCP or a mixture thereof with water in gas or liquid phase or in an aqueous Solution at a temperature above room temperature to obtain an end-product which is essentially pyrogene-free. The pyrogene-free calcium phosphate obtained as an end-product by the method according to the invention can be advantageously used as a bone fixation or bone replacement implant or as a surface layer for a bone fixation or bone replacement implant.

The present invention provides a method for preparing tetracalcium phosphate. The method comprises: (1) heating a fish scale, and grinding the fish scale into powder to obtain fish scale powder; (2) adding a raw material to the fish scale powder for changing a mineral component in the fish scale powder, thereby obtaining a crude material powder; and (3) sintering the crude material powder at a high temperature to obtain a mixture containing tetracalcium phosphate monophosphate.

The invention discloses a medical nano bio-coating and a preparation process thereof. The bio-coating is prepared through the following raw materials of nano-hydroxyapatite, tetracalcium phosphate, graphene quantum dots, strontium monophosphate, dopamine, calcium fluoride, magnesium fluoride, barium ditantalum hexaoxide, silver nitrate, gelatin, ammonium bicarbonate, polyethylene glycol, silk fibroin and phosphohumate. The bonding strength between the bio-coating provided by the invention and a substrate is high; meanwhile, the tenacity is improved, and the deficiency of large brittleness of traditional hydroxyapatite is overcome; and in addition, the bio-coating has good biocompatibility, capable of promoting adherency and growth of bone cells, increasing the repairing and healing rate and shortening the healing period, and good in application and popularization value.

The present invention provides a dentinal tubule sealing material excellent in durability of dentinal tubule sealing performance (acid resistance) and also in storage stability. The present invention relates to a dentinal tubule sealing material including tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B), calcium carbonate particles (C), and a non-aqueous dispersant (D), the dentinal tubule sealing material including 5 to 75 parts by weight of the tetracalcium phosphate particles (A), 10 to 70 parts by weight of the calcium hydrogen phosphate particles (B), and 2 to 50 parts by weight of the calcium carbonate particles (C) per 100 parts by weight of the total of the tetracalcium phosphate particles (A), the calcium hydrogen phosphate particles (B), and the calcium carbonate particles (C).

A method for producing fluorapatite and its application are disclosed in the present invention, which relates to the field of biomaterials for dental reparation. The present invention comprises steps of mixing tetracalcium phosphate, calcium hydrogen phosphate, and sodium fluoride to form a mixture and adding the mixture into water, or mixing tetracalcium phosphate and ammonium fluoride to form a mixture and then adding the mixture into a phosphoric acid/water solution, blending the above two sets of materials respectively to form cement-like substances; and solidifying the cement-like substances at a temperatures of 35° C. to 38° C. and a moisture of 100% for 1-3 days to produce fluorapatite. The synthesized fluorapatite has a similar chemical composition with tooth enamel, thus, the fluorapatite produced by the invention can be combined with the natural enamel directly, so as to repair enamel defects caused by caries, especially severe enamel defects (deep caries). The synthesized fluorapatite has a stoichiometric amount of apatite structure, and has high chemical stability (low solubility) in a physiological condition of human body fluid. In acidic conditions (when bacteria exist) the fluorapatite releases fluorine ion slowly, so it further has an ability to prevent dental caries.

The invention discloses a preparation method of a high-performance modified tetracalcium phosphate 3D (three-dimensional) printing material for biomedicine. According to the method, rare earth materials, silica sol, soluble magnesium salt and the like serve as raw materials, a positive charge magnesium aluminum silicate additive is prepared through high-temperature hydrothermal reaction, high-temperature solid-phase reaction among the additive, calcium sources and phosphorus sources is implemented to prepare a high-purity tetracalcium phosphate powder material, the material can be prepared into a bone material entity finished product with excellent mechanical performances and rich pore structures by a 3D printing mode, and the material has bright industrial application prospects.

The invention discloses a combination for repairing damaged dental enamel, belonging to the field of dental repairing biomaterials. The method comprises steps that tetracalcium phosphate, calcium hydrophosphate and sodium fluoride are mixed, water is added for blending to form cement-like substances, the cement-like substances are filled in carious cavities of carious teeth with damaged enamel, the cement-like substances are cured for 1-3 days under a human body physiological environment to generate fluorapatite, and thereby the carious damaged enamel, especially large damaged enamel (deep caries) can be repaired. Since the synthesized fluorapatite has chemical components similar to the chemical components of the dental enamel, repairing materials can be directly combined with natural dental enamel. The synthesized fluorapatite has a stoichiometric phosphorite structure, the chemical stability under the condition of human physiological body liquid is very high (i.e. the dissolubility is low), fluorions are slowly released under the acidic condition (the existence of bacteria), and thereby the anticarious efficacy is obtained.

The invention belongs to the field of biomedical materials containing active proteins and the field of regenerative medicine, and specifically provides a bone repair material containing rH-BMP2 and phosphate, wherein the bone repair material contains modified chitosan, phosphate and rH-BMP2, can be used for the repair of bone injury, and specifically comprises, by mass, 1-10% of rH-BMP2, 10-50% ofchitosan, 10-50% of tetracalcium phosphate, 5-20% of calcium hydrogen phosphate, 0.2-5% of disodium hydrogen phosphate, and 0.2-5% of sodium dihydrogen phosphate. According to the present invention,the allyltrimethylammonium chloride or acrylamide modified chitosan and the gelatin are used as the sustained-release carrier so as to substantially improve the degradation/drug release time and significantly reduce the allergicity; the results of in vitro release experiments and animal experiments show that the bone repair material of the present invention has good effects significantly superiorto chitosan and existing similar materials; and the results of cytotoxicity test initially prove the safety of the bone repair material of the present invention.

The invention belongs to the field of 3D printing materials, and discloses a 3D printing material for medical bone tissue regeneration. The 3D printing material comprises a powdery material and a cementing solution matched therewith, wherein the powdery material contains the following components in parts by weight: 55-75 parts of tetracalcium phosphate, 65-95 parts of calcium hydrophosphate, 5-20 parts of amorphous silicates, 5-10 parts of fluoride and 5-25 parts of dispersing agent, and the cementing solution contains the following components in parts by weight: 90-100 parts of deionized water, 5-8 parts of sodium hexametaphosphate, 4-6 parts of lecithin, 10-20 parts of surface active agent, 5-10 parts of coagulant, 5-25 parts of binder and 10-15 parts of wetting agent. The invention further discloses a preparation method of the 3D printing material. The printed medical bone tissues not only have strong mechanical strength and compressive property, but also have good biocompatibility, biodegradability and bone conduction and bone regeneration capacity.

The invention belongs to the field of biomedical materials containing active proteins and the field of regenerative medicine, and particularly provides an injection type bone repairing material. The injection type bone repairing material comprises modified chitosan, phosphate and rH-BMP2. The injection type bone repairing material can be used for the repair of bone injuries. The injection type bone repairing material is prepared from the following components in percentage by mass: 1%-10% of rH-BMP2, 10%-40% of chitosan, 10%-50% of tetracalcium phosphate, 5%-15% of calcium hydrophosphate, 5%-10% of gelatin, 0.2%-5% of disodium hydrogen phosphate and 0.2%-5% of sodium dihydrogen phosphate. The chitosan modified with allyltrimethylammonium chloride or acrylamide and the gelatin are used as acontrolled release carrier to achieve great progress in degradability/drug-releasing time, and anaphylaxis is significantly reduced.

The invention discloses a preparation method of an injectable porous calcium phosphate bone repair material. the method provided by the invention is as follows: dicalicium phosphate anhydrous is firstly prepared while chitosan, citric acid and a glucose solution are prepared; mannitol crystals are prepared for later use; chitosan, citric acid and the glucose solution are adopted as a liquid phase, and tetracalcium phosphate and dicalicium phosphate anhydrous are adopted as a solid phase; a pore-forming agent which is composed of mannitol and a polylactic acid-glycolic acid copolymer is added into the solid phase; the solid phase and the liquid phase are successively added into a small culture dish and rapidly stirred with a glass rod for 1-2min so as to form uniform pulp; and the mixture initially has injectable performance, and the porous bone repair material is formed after solidification of the mixture. The repair material prepared by the method has advantages of short solidification time and high compressive strength. Through SEM observation of surface morphology, communication between pores is good. By the preparation method, plasticity and viscoelasticity of CPC can be raised, bone cement is endowed with injectable performance, and application range and application comfort level of bone cement are raised greatly.