Medical nano bio-coating and preparation process thereof

A technology of biological coating and preparation process, which is applied in the field of medical materials to achieve the effect of improving toughness, speeding up repair and healing rate, and promoting the application value.

Inactive Publication Date: 2017-03-29
SUZHOU AIBOMAIER NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For this reason, the present invention provides a kind of medical nano biological coating and preparation technology thereof, solves at least one technical problem in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A medical nano-biological coating, which is prepared from the following raw materials in parts by weight: 32 parts of nano-hydroxyapatite, 11 parts of tetracalcium phosphate, 3 parts of graphene quantum dots, 2 parts of strontium hydrogen phosphate, 4 parts of dopamine, 5 parts of calcium fluoride, 3 parts of magnesium fluoride, 1 part of barium tantalum oxide, 0.1 part of silver nitrate, 6 parts of gelatin, 2 parts of ammonium bicarbonate, 2 parts of polyethylene glycol, 4 parts of silk fibroin, 2 parts of phosphorus humate share.

[0024] Wherein, the size of the nano-hydroxyapatite is 50-100nm.

[0025] Wherein, the molar ratio of barium and tantalum in the barium and tantalum oxide is 5:2.

[0026] The preparation process of the above-mentioned medical nano-biological coating, the specific preparation steps are as follows:

[0027] Step 1, weighing by the above parts by weight;

[0028] Step 2. Ultrasonic disperse needle nano-hydroxyapatite, tetracalcium phosphat...

Embodiment 2

[0033] A medical nano-biological coating, which is prepared from the following raw materials in parts by weight: 48 parts of nano-hydroxyapatite, 26 parts of tetracalcium phosphate, 8 parts of graphene quantum dots, 6 parts of strontium hydrogen phosphate, 8 parts of dopamine, 11 parts of calcium fluoride, 9 parts of magnesium fluoride, 6 parts of barium tantalum oxide, 5 parts of silver nitrate, 14 parts of gelatin, 5 parts of ammonium bicarbonate, 7 parts of polyethylene glycol, 8 parts of silk fibroin, phosphorus humate 6 servings.

[0034] Wherein, the size of the nano-hydroxyapatite is 50-100nm.

[0035] Wherein, the molar ratio of barium and tantalum in the barium and tantalum oxide is 5:2.

[0036] The preparation process of the above-mentioned medical nano-biological coating, the specific preparation steps are as follows:

[0037] Step 1, weighing by the above parts by weight;

[0038] Step 2. Ultrasonic disperse needle nano-hydroxyapatite, tetracalcium phosphate, c...

Embodiment 3

[0043] A medical nano-biological coating, which is prepared from the following raw materials in parts by weight: 34 parts of nano-hydroxyapatite, 12 parts of tetracalcium phosphate, 3.5 parts of graphene quantum dots, 2.2 parts of strontium hydrogen phosphate, 4.6 parts of dopamine, 5.5 parts of calcium fluoride, 3.8 parts of magnesium fluoride, 1.2 parts of barium tantalum oxide, 0.15 parts of silver nitrate, 7 parts of gelatin, 2.6 parts of ammonium bicarbonate, 2.8 parts of polyethylene glycol, 4.5 parts of silk fibroin, 2.3 parts of phosphorus humate share.

[0044] Wherein, the size of the nano-hydroxyapatite is 50-100nm.

[0045] Wherein, the molar ratio of barium and tantalum in the barium and tantalum oxide is 5:2.

[0046] The preparation process of the above-mentioned medical nano-biological coating, the specific preparation steps are as follows:

[0047] Step 1, weighing by the above parts by weight;

[0048] Step 2. Ultrasonic disperse needle nano-hydroxyapatite...

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Abstract

The invention discloses a medical nano bio-coating and a preparation process thereof. The bio-coating is prepared through the following raw materials of nano-hydroxyapatite, tetracalcium phosphate, graphene quantum dots, strontium monophosphate, dopamine, calcium fluoride, magnesium fluoride, barium ditantalum hexaoxide, silver nitrate, gelatin, ammonium bicarbonate, polyethylene glycol, silk fibroin and phosphohumate. The bonding strength between the bio-coating provided by the invention and a substrate is high; meanwhile, the tenacity is improved, and the deficiency of large brittleness of traditional hydroxyapatite is overcome; and in addition, the bio-coating has good biocompatibility, capable of promoting adherency and growth of bone cells, increasing the repairing and healing rate and shortening the healing period, and good in application and popularization value.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a medical nano-biological coating and a preparation process thereof. Background technique [0002] Traditionally, the human body implant bone made of metal materials has excellent mechanical properties, but most metal materials are biologically inert and cannot form chemical bonds with bone in the early stage of implantation, nor have the ability to promote new bone formation. longer. An ideal bone material for human implantation should not only meet the requirements of mechanical properties, but also have excellent antibacterial properties, bioactivity, and biocompatibility. Therefore, the surface of most implanted metal materials must be modified, and the implanted metal materials show that coating biological coatings is one of the most simple and effective treatment methods. [0003] Hydroxyapatite is currently one of the most researched bioactive ceram...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/30A61L27/50
CPCA61L27/34A61L27/303A61L27/306A61L27/32A61L27/50A61L2420/04A61L2420/06A61L2430/02
Inventor 金天洛芸鹤
Owner SUZHOU AIBOMAIER NEW MATERIAL CO LTD
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