590 results about "Irritation" patented technology

The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, lipidosome and a preparation method and application thereof. The acne-removing composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 8 parts of nicotinamide, 1 to 5 parts of cortex magnoliae officinalis extract, 0.15 to 2.01 parts of glycyrrhizic acid, 0.1 to 2 parts of totarol and 0.01 to 0.15 part of hyssopus officinalis extract. The nano-carrier is adopted to wrap and deliver the acne removal composition, so that the solubility of the functional components is increased, the bioavailability of the functional components is improved, meanwhile, the irritation of the functional components is also improved, multi-target co-delivery and multi-mechanism acne removal are realized, and the acne removal composition has a remarkable acne removal effect.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention discloses a moisturizer prepared from a lysate extract produced by fermentation of bacillus subtilis. The hydroxydecyl ubiquinone is identified in Y-3FLE, and the yield of the hydroxydecyl ubiquinone is 0.45 mu g / g after the hydroxydecyl ubiquinone is cultured for 4 days, so that the quinone substances are identified in the Halophilic bacteria in the Yuncheng Salt Lake for the first time. The Y-3FLE is prepared by adopting absolute ethyl alcohol as a solvent, the oxidation resistance of the Y-3FLE is investigated through an in-vitro experiment, and a result shows that the Y-3FLE is relatively high in reducing capacity and relatively high in oxidation resistance. A human body closed patch test result shows that the Y-3FLE has no obvious irritation to human skin. The method is applied to the moisturizer, and human body efficacy evaluation is carried out through a multi-probe skin tester. Results show that the moisturizer added with 1% of Y-3FLE has multiple remarkable effects of moisturizing, repairing, nourishing and the like.

The invention belongs to the field of medicines, and discloses a crystal of difloxacin and a salt-based compound thereof, the grain size of the crystal is 200nm-10mu m, and the crystal is of a sheet structure. The crystal provided by the invention has the particle size of 200nm-10mu m, is of a sheet structure, can stably exist in water in a suspension form, has the advantages of long acting time and small irritation, does not block a needle head, and can be prepared into preparations with various concentrations. Meanwhile, the invention also discloses a preparation method of the crystal.

The invention belongs to the field of medical coatings, and particularly relates to a coating with anesthesia and antibacterial functions and a preparation method thereof. The preparation method comprises the following steps: (I) preparation of a substrate coating, (II) preparation of a drug-loaded hydrogel coating, and (III) preparation of the coating with anesthesia and antibacterial functions. According to the preparation method, on one hand, the problems that nano-particles are insufficient in drug loading capacity, easy to fall off, irritant, non-uniform in release and the like are solved, and on the other hand, the problem that the long-term release performance of hydrogel is not ideal is solved. A plurality of functions (anesthesia and antibiosis) are integrated by pre-treating a substrate material (such as a medical catheter), a commodity suitable for multiple scenes can be prepared, the clinical use is convenient, the adverse reaction of an organism can be greatly reduced, and the risks of secondary intubation and tracheotomy are reduced.

The invention discloses an oil-control composition for whitening and removing acnes. The oil-control composition comprises a raspberry extract, a mangnolia officinalis extract and a natural active matter, the weight ratio of the raspberry extract to the mangnolia officinalis extract to the natural active matter is (0.1-1): (1-5): 1. According to the invention, the raspberry ketone, the magnolia bark extract and the natural active matters are combined, so that the exuberant grease secretion of skin can be fundamentally improved, and inflammation and acne of the skin can be inhibited. Under the optimal weight ratio, the oil can be controlled for a long time, the oil secretion is effectively regulated, the pores are refined, the acne breeding is prevented, and the skin is smoother and finer. The problems that part of current oil control raw materials treat the symptoms but not the root causes, the oil control effect is not lasting, and part of raw materials cause skin thinning and drying and have large irritation to the skin can be solved.

The present application relates to the technical field of eye care liquid, and specifically provides an eye care liquid containing recombinant type III humanized collagen; according to the total mass of the components, the components of the eye care liquid include 0.02-1% sodium hyaluronate, 0.01-0.5% buffer salt, 0.5-1.5% osmotic pressure regulator, 0.001-0.1% recombinant type III humanized collagen, and 100% solvent supplementation. By optimizing the molecular weight of sodium hyaluronate, the pH of the system, etc. and the recombinant type III humanized collagen, the eye care liquid of the present application has a long-lasting moisturizing and soothing effect, and can also effectively stay around the eyeball, and basically does not cause irritation and discomfort to the eyeball.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

The invention relates to a composition with soothing and moisturizing effects and application of the composition. The composition comprises a piper nigrum extract, an oat kernel extract, schizophyllan and tranexamic acid. According to the invention, when the kava pepper extract, the oat kernel extract, the schizophyllan and the tranexamic acid are creatively combined for use, synergistic interaction can be realized in the aspects of soothing skin, moisturizing and repairing skin barrier, and the soothing and moisturizing effects of the product are further improved. The composition with the soothing and moisturizing effects has the specific effects of increasing the water content of the skin, calming and soothing the skin, improving the facial redness condition and reducing the inflammatory response, is very suitable for skin care products, and is mild, free of irritation and good in stability.

The invention discloses a five-membered heterocyclic compound as well as a preparation method, an intermediate, a composition and application thereof. Specifically provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound provided by the invention has excellent biological activity; on one hand, free radicals can be removed, so that activation of tyrosinase is reduced; on the other hand, the activity of activated tyrosinase can be inhibited, and generation of melanin is reduced from multiple aspects; besides, the compound can reduce skin pigmentation induced by ultraviolet (UVB), has no obvious stimulation and inflammatory cell infiltration during administration, is safe and good in tolerance, has better solubility and preparation performance, is good in skin feeling, and is expected to be widely applied in the industries of medicine, cosmetics and beauty. # imgabs0 #

The present invention provides a composition for inhibiting the TRPV1 pathway and reducing skin irritation, comprising camellia extract and purslane extract, the mass ratio of camellia extract to purslane extract being 0.01-10:0.01-10. The composition of the present invention for inhibiting the TRPV1 pathway and reducing skin irritation comprises camellia extract and purslane extract, which inhibit the TRPV1 pathway. Both exhibit a synergistic effect in increasing the irritation response threshold, reducing the skin sensitivity reaction, and relieving tingling, itching, and burning sensations of the skin due to TRPV1 channel activation.

The invention provides an external application medicine for incontinent dermatitis and a preparation method thereof. The composition is prepared from active ingredients such as a radix sophorae flavescentis extract, calamine, vitamin E, ceramide, a herba portulacae extract, glycyrrhizic acid, chitosan and colloidal oat powder according to a specific proportion. Moisturizing matrixes such as sodium hyaluronate and glycerol and functional components such as tea tree essential oil are supplemented. And through a preparation process of matching high-speed shearing with ultrasonic dispersion, uniform dispersion and stability of each component are ensured. Experimental results show that the composition shows a remarkable synergistic effect in the aspects of anti-inflammation, antibiosis, skin barrier repair and the like, the comprehensive relieving and repairing effect of the composition is superior to that of a conventional drug control, and all the components and a special preparation process are necessary for achieving the optimal effect. The product has no irritation to human skin, is good in safety, can be prepared into various dosage forms such as cream, hydrogel or spray, and is suitable for nursing and repairing sensitive skin.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

The present invention provides the use of a toad oil cream in preparing a drug for treating dermatitis, and relates to the field of medical technology. The toad oil cream is composed of toad oil and a matrix, and the toad oil is prepared according to the method of Chinese invention patent application CN117126696 A, and the matrix is ​​composed of cetostearyl alcohol, glyceryl monostearate, liquid paraffin, dimethicone, propylparaben, carbomer, glycerol, potassium lauryl phosphate, hyaluronic acid, methylparaben, triethanolamine and water. The toad oil cream obtained by the present invention can reduce the irritation of toad oil to the skin, improve the spreadability of toad oil, show good therapeutic effects on atopic dermatitis and contact dermatitis, and can be used to treat dermatitis.

The invention discloses a novel compound rapid surface anesthetic and a preparation method thereof, and belongs to the field of pharmaceutical preparations. According to the anesthetic, core anesthetic components of lidocaine and tetracaine are compounded with propylene glycol-laurocapram synergistic penetration enhancer, menthol auxiliary penetration enhancer, carbomer 980 gel matrix, triethanolamine pH regulator, glycerol humectant, panthenol soothing agent, purified water and the like, a surface smearing agent is prepared through a specific process, and the anesthetic can be administered in combination with an iontophoresis technology. Compared with the existing surface anesthetic for the cosmetic surgery, the surface anesthetic disclosed by the invention solves the problems of slow effect taking and poor effect, can realize rapid penetration of local skin, has short anesthesia effect taking time, long duration and good effect, has no obvious irritation to the skin, has good product stability, can effectively reduce the drug toxicity, and has a good application prospect. The device is suitable for surface anesthesia of non-surgical medical beauty items such as skin beauty, laser treatment and water-light micro-needles.

The invention belongs to the field of medicine preparations, and particularly relates to a local external medicine composition for treating alopecia, the medicine composition comprises at least one active component, and the medicine composition comprises the following components in percentage by weight: 1-10% w / w of minoxidil or salt thereof, 0-50% w / w of propylene glycol, 1-50% w / w of ethanol and 10-50% w / w of C3-C10 ether solvent, the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w, and the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w. The pharmaceutical composition at least has the following excellent characteristics: good curative effect, high drug solubility, high patient efficiency, quick response, few adverse reactions, low scalp irritation, good stability, easy use, no greasy feeling after use, good drug permeability, high bioavailability, few use times, good patient compliance and the like.

The invention relates to a dexmedetomidine hydrochloride microneedle which is prepared from a drug-loading needle body layer and a substrate layer, the volume ratio of the drug-loading needle body layer to the substrate layer is 1: 100-200, the drug-loading needle body layer is prepared from polyvinylpyrrolidone and dexmedetomidine hydrochloride according to the mass ratio of 1-15: 1, and the substrate layer is prepared from polyethylene glycol diacrylate through photo-crosslinking. The dexmedetomidine hydrochloride microneedle disclosed by the invention has the advantages that the dexmedetomidine hydrochloride microneedle takes effect quickly, is long in drug effect maintenance time, is non-irritant to skin, avoids infection risk, realizes percutaneous precise administration of dexmedetomidine hydrochloride, and remarkably improves bioavailability and medication safety and effectiveness of dexmedetomidine hydrochloride.

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.

The invention provides a buccal product and a preparation method thereof. In the application, the buccal product comprises the sustained-release agent, the sustained-release agent comprises at least one of a beta-cyclodextrin inclusion compound of the nicotine derivative and carboxylate of the nicotine derivative, and the sustained-release agent can enable the nicotine derivative to be uniformly, slowly and durably released in the oral cavity, so that the residence time of the nicotine derivative in the oral cavity is prolonged; therefore, the buccal product can keep stable strength for a long time, long-acting and mild physiological satisfaction is provided for consumers, and irritation to digestive tracts can be effectively reduced.

The invention belongs to the field of traditional Chinese medicine extracts, and provides a dendrobium extract as well as a preparation method and application thereof. Comprising the following preparation steps: extracting herba artemisiae scopariae with a solvent, enriching anti-bacteriostatic components in the herba artemisiae scopariae, mixing herba dendrobii with the herba artemisiae scopariae extract in proportion, extracting with a solvent, and purifying, refining, filtering and sterilizing an extracting solution through a chromatographic column, so as to prepare the herba dendrobii extract without the preservative, and the herba dendrobii extract can be applied to daily chemical products, medicines and health-care foods. And the shelf life can reach more than 24 months. The dendrobium extract prepared by the preparation method provided by the invention does not need to be added with traditional preservatives, so that the problems of irritation, allergy and the like caused by the preservatives are avoided, and the soothing and anti-inflammatory effects can also be improved.

To provide a nasal cannula which stabilizes a prong inserted in the nasal cavity, is less likely to come off from the nasal cavity, reduces physical irritation, and reduces skin troubles such as redness. [Solution] A nasal cannula 1 includes a prong 2 inserted into a patient's nasal cavity, a tube 4 connected to the prong 2 and placed above the patient's cheek, a cheek pad 9 attached to the patient's cheek, a holder 5 placed above the cheek pad 9 and holding the tube 4 so that it can slide in the tube length direction, and a joint joining the cheek pad 9 to the holder 5. The joint is, for example, a hook-and-loop fastener made up of a female surface 7 on the outside of the holder 5 and a male surface sheet 10 on the upper surface of the cheek pad 9. When a predetermined force is applied to the holder 5 of the tube 4 in a direction away from the cheek, the hook-and-loop fastener is released while the cheek pad 9 remains attached to the cheek, and the tube 4 is detached from the cheek pad 9 together with the holder 5.

The composition is an emulsion formed by mixing an oil phase and a water phase. The oil phase comprises squalane and cyclic siloxane, the water phase takes water as a solvent and comprises a surfactant and polyhydric alcohol, and the surfactant consists of decyl glucoside and cocamidopropyl betaine in a weight ratio of (1: 1)-(2: 1). The composition disclosed by the invention is applied to the medical instrument (such as an adhesive tape, a tension reducing device, an operation dressing and the like) adhered to the skin, and then the medical instrument is stripped from the skin. Through verification, the acting force for stripping the medical instrument is remarkably reduced, compared with three commercially available adhesive removers, the stripping force is also remarkably reduced by nearly one time, the irritation to the skin is slight and is equivalent to normal saline, adhesive residues on the surface of the skin can be mildly removed, and side effects caused by traditional solvent products to the skin are avoided.

The present invention relates to a 5-aminolevulinic acid derivative having improved storage stability and bioavailability, and a pharmaceutical composition comprising same, the present invention exhibiting pharmacokinetic characteristics in which 5-aminolevulinic acid is more effectively exposed to blood in the body, and alleviating side effects such as pain, erythema, swelling, edema, burning, itching, exfoliation, hyperpigmentation, and long-term irritation and hypersensitivity following treatment. In addition, the present invention relates to a 5-aminolevulinic acid derivative and a composition comprising same in which 5-aminolevulinic acid is highly effective while reducing the severity of side effects, and which can be used for photodynamic diagnosis and treatment.

The invention relates to the technical field of acne prevention and treatment, in particular to application of glycyrrhizic acid in preparation of an external product for preventing and treating acne and gel for preventing and treating acne. Research finds that glycyrrhizic acid not only can generate an anti-inflammatory effect, but also can repair a mechanical barrier of skin, and has no adverse effect and no irritation on normal skin, so that glycyrrhizic acid can be used as an active substance for preparing an external product for preventing and treating acne. The gel for preventing and treating acne provided by the invention is prepared from carbomer, xanthan gum, triethanolamine, glycerol, 1, 3-butanediol, propylene glycol, glycyrrhizic acid and other raw materials, has the advantages of good stability, uniform texture, good spreading property and the like, has relatively strong hygroscopicity and moisture retention, can keep a certain degree of hydration of skin, promotes skin barrier repair, and has a good anti-acne effect. The composition is suitable for preventing and treating acne.

The invention relates to an anti-allergic soothing cosmetic and a preparation method thereof. The invention discloses an N-Ala-Phe-Cys-C aqueous solution or an external cosmetic containing N-Ala-Phe-Cys-C for the first time, wherein the N-Ala-Phe-Cys-C aqueous solution or the external cosmetic has anti-allergic soothing effects. The eye cream has excellent single-time and multi-time skin external application safety, and is free of irritation to eyes. Compared with a blank control group, the cosmetics prepared from the 0.01-10% N-Ala-Phe-Cys-C aqueous solution and the formulas 1-4 of the embodiments 5-7 have a remarkable itching relieving effect, and have an inhibiting effect on allergic itching caused by histamine phosphate. Compared with a blank control group, the 0.05%-10% N-Ala-Phe-Cys-C aqueous solution and various formula cosmetics in embodiments 5-7 have a remarkable inhibition effect on auricle swelling caused by xylene.

The aluminum alloy door and window production frame paint spraying device comprises a fixing frame, a paint spraying device body and supporting legs, the paint spraying device body is fixedly connected to the top of the right side of the fixing frame, and the supporting legs are fixedly connected to the four corners of the bottom of the fixing frame. By arranging the controller, the controller starts the extraction mechanism, the extraction mechanism extracts harmful gas, then the harmful gas is filtered through the filtering mechanism, a user is prevented from inhaling a large amount of harmful gas, and then the effect of sucking and filtering the harmful gas is achieved; the problems that volatile organic compounds and other harmful gases are released in the paint spraying process, a structure for sucking and filtering the harmful gases is not provided, and a large amount of gases are sucked to damage body health and even cause serious diseases to stimulate a respiratory system, cause dizziness, nausea and other uncomfortable symptoms, and the like are solved. And certain potential safety hazards exist.

The invention provides an oxytetracycline injection and a preparation method thereof, and belongs to the technical field of medicine preparation, the preparation method comprises the following steps: uniformly mixing 35-50 parts by weight of polyethylene glycol 400 and water, sequentially adding 0.4-0.6 part by weight of sodium formaldehyde sulfoxylate and 1.6-1.8 parts by weight of magnesium oxide, heating, adding 18-22 parts by weight of oxytetracycline, carrying out a complex reaction, adding monoethanolamine to adjust the pH value to 8.4-8.6, and uniformly stirring to obtain the oxytetracycline injection. And fixing the volume and filtering to obtain the oxytetracycline injection. The oxytetracycline injection prepared from the oxytetracycline can effectively improve the stability and the drug effect, prolong the half-life period of the drug and reduce the irritation.

The invention discloses a composition for enhancing cooling feeling and a preparation method and application thereof, and belongs to the technical field of cosmetics. The technical problem to be solved is to provide the composition capable of remarkably enhancing the cool feeling. The composition comprises the following raw materials: a mixture of a butterflybush flower extract, cyclodextrin and dipropylene glycol in a mass ratio of (1-5): (30-60): (35-65). And by combining with cooling factors such as menthol, the cooling feeling and durability can be remarkably improved, and the irritation is remarkably reduced. According to the key point of the technical scheme, the composition for increasing the cooling feeling is prepared from a butterflybush flower extract, cyclodextrin and dipropylene glycol.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with an acne removing effect, a preparation method of the sialic acid composition and cosmetics. The composition is prepared from 8%-20% of sialic acid, 10%-25% of ectoine, 5%-15% of a humectant, 0.1%-1% of a thickening agent, 0.05%-0.5% of a pH regulator and the balance of water. Cubilose acid can promote collagen synthesis, repair damaged skin barrier and reduce inflammatory response caused by external stimulation, and acne generation is inhibited from acne inducement; meanwhile, the sialic acid can inhibit release of proinflammatory factors such as TNF-alpha and IL-6 by adjusting a TLR receptor signal channel, red and swollen pox is relieved, and the generated pox is inhibited from the aspect of inhibiting inflammation; the sialic acid is non-irritant, and can slightly promote cutin renewal under high concentration, so that the problems of skin desquamation, sensitivity and the like caused by barrier injury can be effectively avoided. Ectoin is compounded, so that the Ectoin and sialic acid can generate a synergistic interaction effect.

The present invention relates to the technical field of veterinary medicinal products and specifically to a composition for the treatment of a skin disease in an animal. The main active ingredients of the composition are rapamycin, miconazole, and meloxicam in a mass ratio of (0.01–10):(0.1–20):(0.1–5) and a solvent mixture of water and polyethylene glycol in which the main active ingredients are soluble. The composition has considerable curative effects on fungal infections on the skin surfaces of animals, with low toxicity and minimal irritation.