401 results about "Irritation" patented technology

The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, lipidosome and a preparation method and application thereof. The acne-removing composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 8 parts of nicotinamide, 1 to 5 parts of cortex magnoliae officinalis extract, 0.15 to 2.01 parts of glycyrrhizic acid, 0.1 to 2 parts of totarol and 0.01 to 0.15 part of hyssopus officinalis extract. The nano-carrier is adopted to wrap and deliver the acne removal composition, so that the solubility of the functional components is increased, the bioavailability of the functional components is improved, meanwhile, the irritation of the functional components is also improved, multi-target co-delivery and multi-mechanism acne removal are realized, and the acne removal composition has a remarkable acne removal effect.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention discloses a moisturizer prepared from a lysate extract produced by fermentation of bacillus subtilis. The hydroxydecyl ubiquinone is identified in Y-3FLE, and the yield of the hydroxydecyl ubiquinone is 0.45 mu g / g after the hydroxydecyl ubiquinone is cultured for 4 days, so that the quinone substances are identified in the Halophilic bacteria in the Yuncheng Salt Lake for the first time. The Y-3FLE is prepared by adopting absolute ethyl alcohol as a solvent, the oxidation resistance of the Y-3FLE is investigated through an in-vitro experiment, and a result shows that the Y-3FLE is relatively high in reducing capacity and relatively high in oxidation resistance. A human body closed patch test result shows that the Y-3FLE has no obvious irritation to human skin. The method is applied to the moisturizer, and human body efficacy evaluation is carried out through a multi-probe skin tester. Results show that the moisturizer added with 1% of Y-3FLE has multiple remarkable effects of moisturizing, repairing, nourishing and the like.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

The invention discloses a five-membered heterocyclic compound as well as a preparation method, an intermediate, a composition and application thereof. Specifically provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound provided by the invention has excellent biological activity; on one hand, free radicals can be removed, so that activation of tyrosinase is reduced; on the other hand, the activity of activated tyrosinase can be inhibited, and generation of melanin is reduced from multiple aspects; besides, the compound can reduce skin pigmentation induced by ultraviolet (UVB), has no obvious stimulation and inflammatory cell infiltration during administration, is safe and good in tolerance, has better solubility and preparation performance, is good in skin feeling, and is expected to be widely applied in the industries of medicine, cosmetics and beauty. # imgabs0 #

The invention provides an external application medicine for incontinent dermatitis and a preparation method thereof. The composition is prepared from active ingredients such as a radix sophorae flavescentis extract, calamine, vitamin E, ceramide, a herba portulacae extract, glycyrrhizic acid, chitosan and colloidal oat powder according to a specific proportion. Moisturizing matrixes such as sodium hyaluronate and glycerol and functional components such as tea tree essential oil are supplemented. And through a preparation process of matching high-speed shearing with ultrasonic dispersion, uniform dispersion and stability of each component are ensured. Experimental results show that the composition shows a remarkable synergistic effect in the aspects of anti-inflammation, antibiosis, skin barrier repair and the like, the comprehensive relieving and repairing effect of the composition is superior to that of a conventional drug control, and all the components and a special preparation process are necessary for achieving the optimal effect. The product has no irritation to human skin, is good in safety, can be prepared into various dosage forms such as cream, hydrogel or spray, and is suitable for nursing and repairing sensitive skin.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

The invention discloses a novel compound rapid surface anesthetic and a preparation method thereof, and belongs to the field of pharmaceutical preparations. According to the anesthetic, core anesthetic components of lidocaine and tetracaine are compounded with propylene glycol-laurocapram synergistic penetration enhancer, menthol auxiliary penetration enhancer, carbomer 980 gel matrix, triethanolamine pH regulator, glycerol humectant, panthenol soothing agent, purified water and the like, a surface smearing agent is prepared through a specific process, and the anesthetic can be administered in combination with an iontophoresis technology. Compared with the existing surface anesthetic for the cosmetic surgery, the surface anesthetic disclosed by the invention solves the problems of slow effect taking and poor effect, can realize rapid penetration of local skin, has short anesthesia effect taking time, long duration and good effect, has no obvious irritation to the skin, has good product stability, can effectively reduce the drug toxicity, and has a good application prospect. The device is suitable for surface anesthesia of non-surgical medical beauty items such as skin beauty, laser treatment and water-light micro-needles.

The invention relates to a dexmedetomidine hydrochloride microneedle which is prepared from a drug-loading needle body layer and a substrate layer, the volume ratio of the drug-loading needle body layer to the substrate layer is 1: 100-200, the drug-loading needle body layer is prepared from polyvinylpyrrolidone and dexmedetomidine hydrochloride according to the mass ratio of 1-15: 1, and the substrate layer is prepared from polyethylene glycol diacrylate through photo-crosslinking. The dexmedetomidine hydrochloride microneedle disclosed by the invention has the advantages that the dexmedetomidine hydrochloride microneedle takes effect quickly, is long in drug effect maintenance time, is non-irritant to skin, avoids infection risk, realizes percutaneous precise administration of dexmedetomidine hydrochloride, and remarkably improves bioavailability and medication safety and effectiveness of dexmedetomidine hydrochloride.

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.

The invention belongs to the field of traditional Chinese medicine extracts, and provides a dendrobium extract as well as a preparation method and application thereof. Comprising the following preparation steps: extracting herba artemisiae scopariae with a solvent, enriching anti-bacteriostatic components in the herba artemisiae scopariae, mixing herba dendrobii with the herba artemisiae scopariae extract in proportion, extracting with a solvent, and purifying, refining, filtering and sterilizing an extracting solution through a chromatographic column, so as to prepare the herba dendrobii extract without the preservative, and the herba dendrobii extract can be applied to daily chemical products, medicines and health-care foods. And the shelf life can reach more than 24 months. The dendrobium extract prepared by the preparation method provided by the invention does not need to be added with traditional preservatives, so that the problems of irritation, allergy and the like caused by the preservatives are avoided, and the soothing and anti-inflammatory effects can also be improved.

The invention relates to the technical field of acne prevention and treatment, in particular to application of glycyrrhizic acid in preparation of an external product for preventing and treating acne and gel for preventing and treating acne. Research finds that glycyrrhizic acid not only can generate an anti-inflammatory effect, but also can repair a mechanical barrier of skin, and has no adverse effect and no irritation on normal skin, so that glycyrrhizic acid can be used as an active substance for preparing an external product for preventing and treating acne. The gel for preventing and treating acne provided by the invention is prepared from carbomer, xanthan gum, triethanolamine, glycerol, 1, 3-butanediol, propylene glycol, glycyrrhizic acid and other raw materials, has the advantages of good stability, uniform texture, good spreading property and the like, has relatively strong hygroscopicity and moisture retention, can keep a certain degree of hydration of skin, promotes skin barrier repair, and has a good anti-acne effect. The composition is suitable for preventing and treating acne.

The invention discloses a composition for enhancing cooling feeling and a preparation method and application thereof, and belongs to the technical field of cosmetics. The technical problem to be solved is to provide the composition capable of remarkably enhancing the cool feeling. The composition comprises the following raw materials: a mixture of a butterflybush flower extract, cyclodextrin and dipropylene glycol in a mass ratio of (1-5): (30-60): (35-65). And by combining with cooling factors such as menthol, the cooling feeling and durability can be remarkably improved, and the irritation is remarkably reduced. According to the key point of the technical scheme, the composition for increasing the cooling feeling is prepared from a butterflybush flower extract, cyclodextrin and dipropylene glycol.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with an acne removing effect, a preparation method of the sialic acid composition and cosmetics. The composition is prepared from 8%-20% of sialic acid, 10%-25% of ectoine, 5%-15% of a humectant, 0.1%-1% of a thickening agent, 0.05%-0.5% of a pH regulator and the balance of water. Cubilose acid can promote collagen synthesis, repair damaged skin barrier and reduce inflammatory response caused by external stimulation, and acne generation is inhibited from acne inducement; meanwhile, the sialic acid can inhibit release of proinflammatory factors such as TNF-alpha and IL-6 by adjusting a TLR receptor signal channel, red and swollen pox is relieved, and the generated pox is inhibited from the aspect of inhibiting inflammation; the sialic acid is non-irritant, and can slightly promote cutin renewal under high concentration, so that the problems of skin desquamation, sensitivity and the like caused by barrier injury can be effectively avoided. Ectoin is compounded, so that the Ectoin and sialic acid can generate a synergistic interaction effect.

The present invention relates to the technical field of veterinary medicinal products and specifically to a composition for the treatment of a skin disease in an animal. The main active ingredients of the composition are rapamycin, miconazole, and meloxicam in a mass ratio of (0.01–10):(0.1–20):(0.1–5) and a solvent mixture of water and polyethylene glycol in which the main active ingredients are soluble. The composition has considerable curative effects on fungal infections on the skin surfaces of animals, with low toxicity and minimal irritation.

This invention relates to a low-irritation soothing composition and its application, belonging to the technical field of skin care products. The low-irritation soothing composition, by weight percentage, comprises 0.05–0.2 wt% kava soothing agent, 0.3–1.0 wt% pine nut extract, 1.8–2.5 wt% a mixed emulsifier composed of cetearyl alcohol and glyceryl stearate, wherein the mass ratio of cetearyl alcohol to glyceryl stearate is 2.5–3.5:1; 2.0–5.0 wt% moisturizer, 0.4–1.0 wt% preservative, 0–2.0 wt% cosmetically acceptable excipients, and the balance being water. This invention utilizes the synergistic effect of low concentrations of kava soothing agent and pine nut extract, and employs a low total fat emulsification system to form a delicate and stable O / W emulsion, reducing transepidermal water loss and repairing the physical barrier; together, they maintain a low-inflammatory, low-oxidative, and microbial balanced microenvironment, providing ideal conditions for barrier repair.

The present invention discloses a super-soft anti-deformation medical non-woven fabric and a preparation method thereof. The super-soft anti-deformation medical non-woven fabric comprises a polyurethane composite material layer, a drug release layer, a buffer fluff layer, a composite support layer and a polyethylene layer. The super-soft anti-deformation medical non-woven fabric of the present invention uses the polyurethane composite material layer as the outer layer, which can effectively prevent the influence of the external environment, ensure the wound is dry and clean, reduce the risk of infection, and at the same time increase the flexibility and reduce deformation. The drug release layer can slowly release drugs when contacting body temperature or humidity to promote healing, and poly-N-isopropylacrylamide is used, which can increase the flexibility in the longitudinal and transverse directions and help reduce interlayer deformation. The high-elastic fiber design of the buffer fluff layer can effectively buffer when an external force is applied and reduce the irritation to the skin. The composite support layer forms a network structure, which can ensure the durability during use. It has remarkable protective and medical effects, and the overall flexibility is high, improving the anti-deformation performance.

The invention discloses a multifunctional nursing sanitary pad for preventing and treating bedsore, and belongs to the technical field of sanitary pads, the multifunctional nursing sanitary pad comprises a sanitary pad body, and the sanitary pad body comprises an adhesive layer, a skin-friendly layer, an antibacterial layer, a temperature control layer, a waterproof layer, a breathable layer and a bottom wear-resistant layer. According to the invention, the skin-friendly layer is made of a natural fiber material and is soft and attached to the skin, so that friction stimulation is reduced; the antibacterial layer is loaded with chitosan, tea polyphenol plant extract and propolis metabolite, has broad-spectrum antibacterial, anti-inflammatory and wound healing promoting effects, and effectively inhibits bacterial breeding and infection; the temperature control layer contains a microencapsulated phase-change material which can absorb, store and release heat, so that the local skin temperature is kept stable, and bedsores caused by local overheating or moisture are avoided; the waterproof layer is made of a polyethylene material, so that seepage is prevented from reversely permeating to pollute skin; the breathable layer is provided with the breathable holes distributed in a net shape, so that air circulation is remarkably improved; the bottom wear-resistant layer is made of polyester fibers, so that the overall structural strength and durability are enhanced.

The invention relates to the technical field of skin care products, in particular to a sterile plant flower water stock solution and a preparation method and application thereof. The sterile plant flower water stock solution is prepared from the following raw materials in parts by mass: 5 to 30 parts of green rattan flower water, 5 to 30 parts of cancerous bulbophyllum flower water, 5 to 30 parts of strelitzia reginae flower water, 5 to 30 parts of maifangzi flower water, 0.05 to 1 part of pachymaran, 0.01 to 0.05 part of natto gum, 1 to 10 parts of snail mucus extract and 0.75 to 14 parts of elastin. Through a unique synergistic mechanism in the aspects of oxidation resistance, anti-inflammatory relieving and moisturizing and moistening when the green tuberous root flower water, the cancerous cancerous flower water, the strelitzia reginae flower water and the maifang flower water have a synergistic effect, skin inflammation is relieved synergistically from multiple brand-new angles, and red, swollen and pruritus symptoms caused by allergy and stimulation are relieved.

The invention discloses essence with uniformly distributed oil drops and a preparation process thereof, and relates to the field of cosmetics, the essence comprises a water phase component and an oil phase component, the water phase component comprises 50-99 parts by weight of purified water, 2-30 parts by weight of a moisturizing factor, 0.001-0.2 part by weight of a chelating agent, 0.001-5 parts by weight of a thickening agent, and 0.5-2 parts by weight of a preservative; the oil phase component comprises 1-15 parts by weight of a grease component; the essence is in a transparent state, oil drops are uniformly distributed, and no emulsifier is added, so that the problems of skin allergy, irritation and the like possibly caused by the emulsifier are avoided, the product is more suitable for being used by sensitive skin, the original characteristics of water and oil are reserved, and purer use experience is brought to consumers; the whole product is in a transparent state, oil drops are in a suspended state, and the product can be sprayed and smeared and has unique sense of science and technology and visual attraction.

The invention provides an Ectoine-containing composition for periocular care and an application of the Ectoine-containing composition. The first aspect of the application provides an Ectoin-containing composition for periocular care, the Ectoin-containing composition for periocular care comprises active components, and the active components comprise 1-10 parts by mass of Ectoin and 3-5 parts by mass of bakuchiol. Bakuchiol is called'plant retinol ', is milder than retinol, has lower irritation to skin, and can improve the effectiveness of endogenous and exogenous retinol at the same time, thereby promoting the generation of collagen; meanwhile, Ectoin is compounded on the basis of bakuchiol, and the result shows that the composition has more excellent performance in the aspect of promoting collagen generation, and has higher effectiveness in the aspects of removing periorbital wrinkles and eliminating under-eye puffiness.

Described herein are topical compositions for cosmetic use in a subject in need thereof, wherein the composition comprises emulsified substituted or unsubstituted diindolylmethane and a pharmaceutically acceptable carrier, and wherein the composition does not cause irritation or allergic reaction after topical application. In addition, methods are provided for improving the dermal bioavailability of substituted or unsubstituted diindolylmethane through topical administration, relative to other route of administration such as oral administration.

The invention belongs to the technical field of moxibustion cabins, and discloses a full-automatic intelligent moxibustion cabin with a smoke purifying function, which comprises a moxibustion cabin body, a box body is fixedly mounted in the moxibustion cabin body, a supporting round block is fixedly mounted at the top of the box body, a threaded sleeve I is fixedly mounted at the bottom of the supporting round block, and a smoke purifying device is fixedly mounted at the bottom of the threaded sleeve I; a first threaded rod is movably mounted in the first threaded sleeve. Compared with a traditional moxibustion cabin, the moxibustion cabin has the advantages that the first teeth and the second teeth are matched, the height of the moxibustion box and the height of the moxibustion plate can be reasonably adjusted according to the internal temperature of the moxibustion cabin body, in this way, it can be ensured that the moxibustion temperature is appropriate, and irritation or discomfort caused by too high or too low temperature to the skin is avoided; by accurately adjusting the heights of the moxibustion box and the moxibustion plate, the moxibustion device can be better aligned to acupuncture points or treatment parts, the treatment effect is improved, and meanwhile the moxibustion box and the moxibustion plate can be flexibly adjusted in a matched mode.

The present invention relates to a combination product comprising, as active substances, at least erysimum, propolis, zinc, ribwort plantain, and marshmallow. The invention also relates to the use of a combination product as defined above for treating the symptoms associated with upper respiratory tract infections. Finally, the invention relates to the use of a combination product as defined above for treating the symptoms associated with throat infections and irritation.

The present invention belongs to the technical field of biomedicine, and particularly relates to an anesthetic preparation containing trimecaine and a preparation method thereof. The anesthetic preparation containing trimecaine comprises the following raw materials in parts by weight: 8-12 parts of trimecaine, 0.5-1 part of lindenenolide, 0.3-0.8 part of sodium phytate, 1-5 parts of schizophyllan oligosaccharide, 3-5 parts of 1,2-propanediol, 2-6 parts of sodium carboxymethylcellulose, 3-8 parts of Tween, and 60-70 parts of physiological saline. The combination of lindenenolide and trimecaine added in the anesthetic preparation of the present invention can improve the anesthetic effect and prolong the anesthetic time. Sodium phytate and schizophyllan oligosaccharide in the anesthetic preparation act synergistically to effectively improve the stability of the anesthetic preparation. Among them, due to the film-forming property of schizophyllan oligosaccharide, it can also improve the anesthetic efficacy of the anesthetic preparation to a certain extent. In addition, the anesthetic prepared by the present invention has no obvious irritation to the skin.

The invention discloses an alprazolam nasal spray and a preparation method thereof, and provides the alprazolam nasal spray which is good in stability, small in irritation, convenient, quick to take effect and extremely small in side effect, so that the medication compliance of a patient and the convenience of clinical medication are improved, and the preparation process is simple to operate, safe, environment-friendly and suitable for industrial mass production.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a more low-irritation analgesic ancient prescription microemulsion gel and application thereof in anti-arthritis drugs. The application finds that after water-soluble and fat-soluble components of black plaster prepared from raw frankincense, myrrh, eaglewood, dragon's blood, Strychnos nux-vomica, Panax notoginseng, Oldenlandia diffusa, Venenum Bufonis, bovine bezoar, Stachys jamaicensis, Platycodon grandiflorum, Hirudo nipponia, Tinea, Solenopsis geminata, Scorpio, scorpio, red lead and sesame oil are extracted, a more low-irritation analgesic ancient prescription microemulsion gel is prepared; compared with the black plaster itself, the analgesic effect of the microemulsion gel is significantly improved, and the microemulsion gel has good anti-inflammatory effect and can be used for preparing anti-arthritis drugs; and the microemulsion gel has reduced toxicity and is more convenient to use.

The invention discloses a supramolecular hydrogel composition as well as a preparation method and application thereof, and belongs to the technical field of beauty treatment. The supramolecular hydrogel composition provided by the invention is prepared from the following raw materials in percentage by mass: the balance of water; 2 to 30 percent of poloxamer; 1-35% of an active substance; 0.5%-20% of a cross-linking agent; and 1-20% of polyol. The supramolecular hydrogel composition provided by the invention can significantly reduce the irritation to the skin on the basis of effectively improving the content of active substances and the bioavailability of the active substances in the supramolecular hydrogel composition. The invention also provides a preparation method and application of the supramolecular hydrogel composition.

The invention discloses antibiotic-free hydrogel for nursing staphylococcus aureus infection as well as a preparation method and application of the antibiotic-free hydrogel. The hydrogel is prepared from metal ion compounds such as zinc ions, copper ions and iron ion compounds, a natural high polymer material and an antioxidant as raw materials, and has the advantages of efficient antibacterial property, high safety, long-acting slow release and the like. An in-vitro antibacterial experiment shows that the sterilizing rate of the metal ion compound on staphylococcus aureus can reach 90%-99.9%; animal experiments prove that the hydrogel can effectively relieve inflammatory reaction of infected parts, and skin irritation experiments show that the product is free of irritation and anaphylactic reaction. The invention provides a safe and effective nonreactive solution for nursing of staphylococcus aureus infection.

The invention discloses a dexketoprofen trometamol nasal spray and a preparation method thereof, a buffering agent is used as a stabilizer, and the dexketoprofen trometamol nasal spray which is good in stability, small in irritation, convenient, rapid in effect taking and extremely small in side effect is provided, so that the medication compliance of patients and the convenience of clinical medication are improved; after being administrated, the nasal spray can be quickly absorbed through nasal mucosa, the absorption speed is equivalent to that of intramuscular injection, the nasal spray can quickly reach the peak concentration as intramuscular injection, and the curative effect can be quickly exerted; the preparation has the advantages of no first-pass effect during nasal mucosa administration, high bioavailability and rapid absorption, is suitable for self-rapid analgesia, and is stable in process and suitable for large-scale production.