289 results about "Irritation" patented technology

The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, lipidosome and a preparation method and application thereof. The acne-removing composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 8 parts of nicotinamide, 1 to 5 parts of cortex magnoliae officinalis extract, 0.15 to 2.01 parts of glycyrrhizic acid, 0.1 to 2 parts of totarol and 0.01 to 0.15 part of hyssopus officinalis extract. The nano-carrier is adopted to wrap and deliver the acne removal composition, so that the solubility of the functional components is increased, the bioavailability of the functional components is improved, meanwhile, the irritation of the functional components is also improved, multi-target co-delivery and multi-mechanism acne removal are realized, and the acne removal composition has a remarkable acne removal effect.

The invention discloses an antibacterial breathable dressing patch and a preparation method thereof, and belongs to the field of medical dressings, the antibacterial breathable dressing patch comprises a Janus type dressing patch layer which is a composite film containing a hydrocolloid matrix, pH response antibacterial microspheres and bioactive glass nanoparticles; the super-hydrophobic electrostatic spinning outer layer is a super-hydrophobic electrostatic spinning fiber membrane, and the super-hydrophobic electrostatic spinning outer layer and the Janus type dressing skin-attaching layer are compounded to form an asymmetric Janus structure, intellectualization and precision of the antibacterial effect are achieved, and the risks of cytotoxicity and bacterial drug resistance possibly caused by long-term exposure to an antibacterial agent are reduced to the maximum extent; a multi-mechanism and synergistic antibacterial defense system is constructed, more comprehensive and firm protection is provided for wounds, the air permeability and moisture permeability are excellent, a dry and moist ideal healing environment is created for the wounds, the biocompatibility is good, the use safety is high, the wound healing agent is mild to human tissues, the irritation is low, the allergic reaction risk is small, the safety is high, and the wound healing effect is good. The long-term use is facilitated.

The invention provides an external application medicine for incontinent dermatitis and a preparation method thereof. The composition is prepared from active ingredients such as a radix sophorae flavescentis extract, calamine, vitamin E, ceramide, a herba portulacae extract, glycyrrhizic acid, chitosan and colloidal oat powder according to a specific proportion. Moisturizing matrixes such as sodium hyaluronate and glycerol and functional components such as tea tree essential oil are supplemented. And through a preparation process of matching high-speed shearing with ultrasonic dispersion, uniform dispersion and stability of each component are ensured. Experimental results show that the composition shows a remarkable synergistic effect in the aspects of anti-inflammation, antibiosis, skin barrier repair and the like, the comprehensive relieving and repairing effect of the composition is superior to that of a conventional drug control, and all the components and a special preparation process are necessary for achieving the optimal effect. The product has no irritation to human skin, is good in safety, can be prepared into various dosage forms such as cream, hydrogel or spray, and is suitable for nursing and repairing sensitive skin.

The invention discloses a novel compound rapid surface anesthetic and a preparation method thereof, and belongs to the field of pharmaceutical preparations. According to the anesthetic, core anesthetic components of lidocaine and tetracaine are compounded with propylene glycol-laurocapram synergistic penetration enhancer, menthol auxiliary penetration enhancer, carbomer 980 gel matrix, triethanolamine pH regulator, glycerol humectant, panthenol soothing agent, purified water and the like, a surface smearing agent is prepared through a specific process, and the anesthetic can be administered in combination with an iontophoresis technology. Compared with the existing surface anesthetic for the cosmetic surgery, the surface anesthetic disclosed by the invention solves the problems of slow effect taking and poor effect, can realize rapid penetration of local skin, has short anesthesia effect taking time, long duration and good effect, has no obvious irritation to the skin, has good product stability, can effectively reduce the drug toxicity, and has a good application prospect. The device is suitable for surface anesthesia of non-surgical medical beauty items such as skin beauty, laser treatment and water-light micro-needles.

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.

The invention discloses a composition for enhancing cooling feeling and a preparation method and application thereof, and belongs to the technical field of cosmetics. The technical problem to be solved is to provide the composition capable of remarkably enhancing the cool feeling. The composition comprises the following raw materials: a mixture of a butterflybush flower extract, cyclodextrin and dipropylene glycol in a mass ratio of (1-5): (30-60): (35-65). And by combining with cooling factors such as menthol, the cooling feeling and durability can be remarkably improved, and the irritation is remarkably reduced. According to the key point of the technical scheme, the composition for increasing the cooling feeling is prepared from a butterflybush flower extract, cyclodextrin and dipropylene glycol.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with an acne removing effect, a preparation method of the sialic acid composition and cosmetics. The composition is prepared from 8%-20% of sialic acid, 10%-25% of ectoine, 5%-15% of a humectant, 0.1%-1% of a thickening agent, 0.05%-0.5% of a pH regulator and the balance of water. Cubilose acid can promote collagen synthesis, repair damaged skin barrier and reduce inflammatory response caused by external stimulation, and acne generation is inhibited from acne inducement; meanwhile, the sialic acid can inhibit release of proinflammatory factors such as TNF-alpha and IL-6 by adjusting a TLR receptor signal channel, red and swollen pox is relieved, and the generated pox is inhibited from the aspect of inhibiting inflammation; the sialic acid is non-irritant, and can slightly promote cutin renewal under high concentration, so that the problems of skin desquamation, sensitivity and the like caused by barrier injury can be effectively avoided. Ectoin is compounded, so that the Ectoin and sialic acid can generate a synergistic interaction effect.

The present invention relates to the technical field of veterinary medicinal products and specifically to a composition for the treatment of a skin disease in an animal. The main active ingredients of the composition are rapamycin, miconazole, and meloxicam in a mass ratio of (0.01–10):(0.1–20):(0.1–5) and a solvent mixture of water and polyethylene glycol in which the main active ingredients are soluble. The composition has considerable curative effects on fungal infections on the skin surfaces of animals, with low toxicity and minimal irritation.

This invention relates to a low-irritation soothing composition and its application, belonging to the technical field of skin care products. The low-irritation soothing composition, by weight percentage, comprises 0.05–0.2 wt% kava soothing agent, 0.3–1.0 wt% pine nut extract, 1.8–2.5 wt% a mixed emulsifier composed of cetearyl alcohol and glyceryl stearate, wherein the mass ratio of cetearyl alcohol to glyceryl stearate is 2.5–3.5:1; 2.0–5.0 wt% moisturizer, 0.4–1.0 wt% preservative, 0–2.0 wt% cosmetically acceptable excipients, and the balance being water. This invention utilizes the synergistic effect of low concentrations of kava soothing agent and pine nut extract, and employs a low total fat emulsification system to form a delicate and stable O / W emulsion, reducing transepidermal water loss and repairing the physical barrier; together, they maintain a low-inflammatory, low-oxidative, and microbial balanced microenvironment, providing ideal conditions for barrier repair.

The invention discloses a multifunctional nursing sanitary pad for preventing and treating bedsore, and belongs to the technical field of sanitary pads, the multifunctional nursing sanitary pad comprises a sanitary pad body, and the sanitary pad body comprises an adhesive layer, a skin-friendly layer, an antibacterial layer, a temperature control layer, a waterproof layer, a breathable layer and a bottom wear-resistant layer. According to the invention, the skin-friendly layer is made of a natural fiber material and is soft and attached to the skin, so that friction stimulation is reduced; the antibacterial layer is loaded with chitosan, tea polyphenol plant extract and propolis metabolite, has broad-spectrum antibacterial, anti-inflammatory and wound healing promoting effects, and effectively inhibits bacterial breeding and infection; the temperature control layer contains a microencapsulated phase-change material which can absorb, store and release heat, so that the local skin temperature is kept stable, and bedsores caused by local overheating or moisture are avoided; the waterproof layer is made of a polyethylene material, so that seepage is prevented from reversely permeating to pollute skin; the breathable layer is provided with the breathable holes distributed in a net shape, so that air circulation is remarkably improved; the bottom wear-resistant layer is made of polyester fibers, so that the overall structural strength and durability are enhanced.

The invention discloses essence with uniformly distributed oil drops and a preparation process thereof, and relates to the field of cosmetics, the essence comprises a water phase component and an oil phase component, the water phase component comprises 50-99 parts by weight of purified water, 2-30 parts by weight of a moisturizing factor, 0.001-0.2 part by weight of a chelating agent, 0.001-5 parts by weight of a thickening agent, and 0.5-2 parts by weight of a preservative; the oil phase component comprises 1-15 parts by weight of a grease component; the essence is in a transparent state, oil drops are uniformly distributed, and no emulsifier is added, so that the problems of skin allergy, irritation and the like possibly caused by the emulsifier are avoided, the product is more suitable for being used by sensitive skin, the original characteristics of water and oil are reserved, and purer use experience is brought to consumers; the whole product is in a transparent state, oil drops are in a suspended state, and the product can be sprayed and smeared and has unique sense of science and technology and visual attraction.

The invention provides an Ectoine-containing composition for periocular care and an application of the Ectoine-containing composition. The first aspect of the application provides an Ectoin-containing composition for periocular care, the Ectoin-containing composition for periocular care comprises active components, and the active components comprise 1-10 parts by mass of Ectoin and 3-5 parts by mass of bakuchiol. Bakuchiol is called'plant retinol ', is milder than retinol, has lower irritation to skin, and can improve the effectiveness of endogenous and exogenous retinol at the same time, thereby promoting the generation of collagen; meanwhile, Ectoin is compounded on the basis of bakuchiol, and the result shows that the composition has more excellent performance in the aspect of promoting collagen generation, and has higher effectiveness in the aspects of removing periorbital wrinkles and eliminating under-eye puffiness.

Described herein are topical compositions for cosmetic use in a subject in need thereof, wherein the composition comprises emulsified substituted or unsubstituted diindolylmethane and a pharmaceutically acceptable carrier, and wherein the composition does not cause irritation or allergic reaction after topical application. In addition, methods are provided for improving the dermal bioavailability of substituted or unsubstituted diindolylmethane through topical administration, relative to other route of administration such as oral administration.

The invention belongs to the technical field of moxibustion cabins, and discloses a full-automatic intelligent moxibustion cabin with a smoke purifying function, which comprises a moxibustion cabin body, a box body is fixedly mounted in the moxibustion cabin body, a supporting round block is fixedly mounted at the top of the box body, a threaded sleeve I is fixedly mounted at the bottom of the supporting round block, and a smoke purifying device is fixedly mounted at the bottom of the threaded sleeve I; a first threaded rod is movably mounted in the first threaded sleeve. Compared with a traditional moxibustion cabin, the moxibustion cabin has the advantages that the first teeth and the second teeth are matched, the height of the moxibustion box and the height of the moxibustion plate can be reasonably adjusted according to the internal temperature of the moxibustion cabin body, in this way, it can be ensured that the moxibustion temperature is appropriate, and irritation or discomfort caused by too high or too low temperature to the skin is avoided; by accurately adjusting the heights of the moxibustion box and the moxibustion plate, the moxibustion device can be better aligned to acupuncture points or treatment parts, the treatment effect is improved, and meanwhile the moxibustion box and the moxibustion plate can be flexibly adjusted in a matched mode.

The present invention relates to a combination product comprising, as active substances, at least erysimum, propolis, zinc, ribwort plantain, and marshmallow. The invention also relates to the use of a combination product as defined above for treating the symptoms associated with upper respiratory tract infections. Finally, the invention relates to the use of a combination product as defined above for treating the symptoms associated with throat infections and irritation.

The invention discloses an alprazolam nasal spray and a preparation method thereof, and provides the alprazolam nasal spray which is good in stability, small in irritation, convenient, quick to take effect and extremely small in side effect, so that the medication compliance of a patient and the convenience of clinical medication are improved, and the preparation process is simple to operate, safe, environment-friendly and suitable for industrial mass production.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a more low-irritation analgesic ancient prescription microemulsion gel and application thereof in anti-arthritis drugs. The application finds that after water-soluble and fat-soluble components of black plaster prepared from raw frankincense, myrrh, eaglewood, dragon's blood, Strychnos nux-vomica, Panax notoginseng, Oldenlandia diffusa, Venenum Bufonis, bovine bezoar, Stachys jamaicensis, Platycodon grandiflorum, Hirudo nipponia, Tinea, Solenopsis geminata, Scorpio, scorpio, red lead and sesame oil are extracted, a more low-irritation analgesic ancient prescription microemulsion gel is prepared; compared with the black plaster itself, the analgesic effect of the microemulsion gel is significantly improved, and the microemulsion gel has good anti-inflammatory effect and can be used for preparing anti-arthritis drugs; and the microemulsion gel has reduced toxicity and is more convenient to use.

The invention discloses a dexketoprofen trometamol nasal spray and a preparation method thereof, a buffering agent is used as a stabilizer, and the dexketoprofen trometamol nasal spray which is good in stability, small in irritation, convenient, rapid in effect taking and extremely small in side effect is provided, so that the medication compliance of patients and the convenience of clinical medication are improved; after being administrated, the nasal spray can be quickly absorbed through nasal mucosa, the absorption speed is equivalent to that of intramuscular injection, the nasal spray can quickly reach the peak concentration as intramuscular injection, and the curative effect can be quickly exerted; the preparation has the advantages of no first-pass effect during nasal mucosa administration, high bioavailability and rapid absorption, is suitable for self-rapid analgesia, and is stable in process and suitable for large-scale production.

The invention discloses an amino acid facial cleanser composition and application thereof, and aims to overcome the defects that the existing acne-removing facial cleanser is high in irritation, acne removal and mild cleaning are difficult to consider, and a single component only acts on a single target spot of acne. According to the composition, 5.0-25.0 wt% of sodium cocoyl glycinate, 0.1-2.0 wt% of capryloyl glycine, 0.2-5.0 wt% of nicotinamide and 0.01-0.5 wt% of a hydrolysis yeast extract are taken as core active components, the four components are specifically proportioned to form a synergistic effect, oil control and acne removal are realized through a closed-loop passage of pore cleaning, source oil control and targeted bacteriostasis, and the mild property is guaranteed by amino acid surface activity, and the skin barrier is not damaged. The composition disclosed by the invention can be prepared into facial cleanser and facial mousse, and is excellent in cleaning power and foamability, good in use experience and high in industrialization value.

The invention discloses clobetasol propionate liniment and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The clobetasol propionate liniment provided by the invention consists of clobetasol propionate and dipotassium glycyrrhizinate which serve as effective components, absolute ethyl alcohol serving as a cosolvent and a novel eutectic solvent aqueous solution. The eutectic solvent aqueous solution is prepared by heating a citric acid aqueous solution and a tartaric acid aqueous solution under specific conditions. The invention also provides a method for preparing the clobetasol propionate liniment. A eutectic solvent formed by citric acid and tartaric acid is used as a main solvent, so that the use amount of absolute ethyl alcohol is reduced, and the use irritation is reduced. According to the liniment, the solubility and stability of clobetasol propionate which is extremely difficult to dissolve in water in a liniment system are improved, meanwhile, the formula system is mild, skin irritation caused by ethyl alcohol is reduced, and the liniment has good safety and application prospects.

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

Embodiments provide targeted delivery of powder medications (high and low dose) within the nose and to different nasal regions. Oscillating jet technology provides a unique approach to minimize hotspot formation and the associated irritation associated with high powder mass applications together with improved posterior surface area coverage and improved drug absorption for locally acting or systemically and neurologically targeted medications.

The invention discloses a full-automatic proofing and cooking integrated production line which comprises a preparation frame and a fermentation room, the preparation frame is arranged on one side of the fermentation room, the preparation frame comprises a fixed frame, a movable frame is movably arranged in the fixed frame, universal wheels are arranged at the bottom of the movable frame, and the movable frame enables an object to be processed to enter the fermentation room through the universal wheels; all links of the production line achieve automatic operation through cooperation of a motor, an air cylinder, a detection switch and a control system, frequent manual intervention is not needed, the production yield in unit time is increased, and the large-scale industrial production requirement is met; multiple detection and limiting devices are arranged on the production line, it is guaranteed that conveying and operation of all links are accurate and controllable, and the quality stability of each batch of products is guaranteed; through automatic operation, direct contact between workers and equipment and a high-temperature environment is reduced, manual operation risks are reduced, and potential safety hazards such as skin scalding and respiratory tract stimulation are reduced.

This utility model discloses a tracheostomy nebulization and heating device, including a tracheostomy mask, an air delivery tube, a nebulizer, a fine-tuning infusion set, a constant-temperature heater, and an infusion tubing. Both ends of the infusion tubing are connected to the inlets of the fine-tuning infusion set and the nebulizer, respectively. Both ends of the air delivery tube are connected to the outlets of the tracheostomy mask and the nebulizer, respectively. The constant-temperature heater is located on the outside of the infusion tubing. By incorporating the fine-tuning infusion set and connecting it to the nebulizer, the input rate of the humidifying liquid can be controlled by adjusting the fine-tuning infusion set, avoiding the discontinuity of traditional manual water addition, ensuring a stable and sustained humidification process, and reducing airway mucosal irritation caused by humidity fluctuations. The constant-temperature heater on the outside of the infusion tubing heats the humidifying liquid, preheating it before nebulization, preventing cold mist from directly entering the airway and avoiding discomfort caused by inhaling cold air.

The present invention addresses the problem of providing an alcohol-containing composition in which the irritation of alcohol is reduced. In a composition containing alcohol, linalool and / or geraniol is blended, and cis-3-hexene-1-ol is blended.

The application discloses a composition with soothing anti-inflammatory anti-wrinkle firming efficacy and a preparation method thereof, and the composition comprises a TRPV1 inhibitor, an extract of Glycyrrhiza inflata Bat., palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The four raw materials are compounded to have a synergistic effect, reduce the release of pro-inflammatory mediators and inhibit the high reactivity of nerve fibers to achieve soothing anti-inflammatory and anti-irritation; promote the generation of self collagen and sodium hyaluronate, reduce the oxidative stress response to achieve the anti-wrinkle firming efficacy and delay skin aging. The composition has comprehensive effects in soothing, anti-inflammatory, anti-irritation, anti-oxidation, anti-wrinkle and firming, reduces the generation of inflammation and delays skin aging, relieves the burning and stinging sensation of the skin at the same time, and meets the requirements of safety and high efficiency pursued by sensitive skin groups.

The application discloses a chronic ulcer wound repairing gel and a preparation method and application thereof, and belongs to the technical field of medical materials. Since bacterial cellulose has the advantages of good biocompatibility, high water retention and moisturizing capacity, strong mechanical property, good air permeability, low toxicity and the like, the bacterial cellulose is used to prepare the bacterial cellulose-based chronic ulcer wound repairing gel capable of promoting chronic wound healing by compounding functional components. The gel can bidirectionally regulate the wet balance of a wound surface; contains a large amount of hydroxyl groups, can highly retain water, has an ice-cool feeling, effectively relieves pain, simultaneously reduces irritation to a wound and a mucous membrane, reduces the sensitivity of exposed nerves, and reduces pain; the photosensitizer in the gel can inhibit bacterial infection by irradiation of near-infrared laser; active components can inhibit inflammatory diffusion, promote collagen deposition and angiogenesis, and the like, so as to promote the healing of a chronic ulcer wound surface.

The present invention relates to a composition for improving skin condition, the composition comprising 15-HEPE, 5,15-HETE, or a combination thereof. The composition comprising 15-HEPE, 5,15-HETE, or a combination thereof according to one aspect alleviates skin inflammation or irritation, and exhibits skin barrier-strengthening, wrinkle-reducing, moisturizing, and skin cell-regenerating effects, and thus may be used as a cosmetic or a skin external preparation and the like for improving skin condition.

The application discloses a low-irritation borage oil nano-liposome, a diaper-care preparation and application of the diaper-care preparation in diaper rash of infants and young children, and belongs to the field of infant skin-care preparations. The nano-liposome is composed of the following components in percentage by weight: 0.5-2.0% of biodecolorized borage oil, 1.0-3.0% of chitosan oligosaccharide-ceramide binary membrane material, 0.3-1.0% of prebiotic skin flora regulator, 0.8-1.5% of pH 5.5 weak acid buffer system, 0.05-0.2% of edible-grade microencapsulated menthol, and the balance of sterile water for injection. The application also provides a diaper-care preparation containing the low-irritation borage oil nano-liposome, which is suitable for daily prevention and acute-phase intervention of infants and young children aged 0-36 months, has the characteristics of high bioavailability, low irritation, rapid repair and easy carrying, and has important clinical application value.

Provided herein are ketamine formulations for subcutaneous injection, in particular subcutaneous formulations of ketamine useful for the treatment of various diseases and disorders. The subcutaneous ketamine preparation provided by the invention reduces stimulation and pain of an injection site.