The present invention pertains to methods of using certain 1-di-
isopropyl-phosphinoyl-alkanes as described herein (DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as “DIPA compounds”) for the treatment of ocular discomfort that is caused by eye strain;
eye surgery; an airborne irritant or
pollutant that interacts with the eye surface; heat discomfort;
extended wear of contact lenses; excessive
exposure to the sun; asthenopia; conjunctivitis; or a dry eye syndrome. The present invention also pertains to pharmaceutical compositions comprising such compounds, and media contain those pharmaceutical compositions.