7results about How to "Increase pain" patented technology

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for treating diabetic peripheral neuropathy, which comprises the exclusive active enrichment part of eight kinds of traditional Chinese medicines such as Astragalus, Radix Rehmanniae, and Caulis Sargentodoxae, and is combined with pharmaceutical excipients. The preparation establishes the therapeutic principle of tonifying qi and nourishing yin, removing blood stasis and dredging collaterals, tonifying kidney and protecting marrow, and directly attacks the core pathogenesis of the disease. The effective components are precisely enriched by using the processes of enzymolysis, aqueous two-phase extraction, and ultrafiltration, and the pH-dependent enteric-soluble pellet capsules are optimized to improve the bioavailability and reduce the gastrointestinal irritation. The pharmacodynamics confirms that the product can regulate glucose metabolism, resist oxidative stress, inhibit inflammation, improve nerve microcirculation, repair damaged nerve myelin sheath, significantly improve the pain threshold and nerve conduction velocity, and the curative effect is better than that of conventional Chinese and western medicines. The acute and long-term toxicity tests show that the product has high safety, the process is stable and controllable, and is suitable for industrial production, thereby providing an efficient and safe treatment option for the disease.

This invention provides a traditional Chinese medicine preparation for promoting blood circulation and relieving pain, and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from the following parts by weight of traditional Chinese medicine raw materials: 10-30 parts of Polygonatum sibiricum, 10-30 parts of Spatholobus suberectus, 10-30 parts of Curcuma longa, 5-20 parts of Sparganium stoloniferum, 5-20 parts of Areca catechu peel, 5-20 parts of Polygonum hydropiper, 5-20 parts of Rhizoma Scutellariae, 1-5 parts of Artemisia argyi, 5-20 parts of Solanum nigrum, 5-20 parts of Catechu, 10-30 parts of Scutellaria barbata, 5-20 parts of Aristolochia debilis, 10-30 parts of Astragalus membranaceus, and 5-20 parts of Artemisia argyi oil. The traditional Chinese medicine preparations described in this invention differ from those that typically enhance the efficacy of a single herb. Instead, they exhibit a synergistic relationship where one plus one equals more than two. The principal, assistant, adjuvant, and guide herbs complement each other, combining both tonifying and purging effects. This approach effectively promotes the dissipation of blood stasis, unblocks the flow of qi and blood in the meridians, eliminates local inflammation, and reduces swelling and pain. Simultaneously, it nourishes the tendons and bones, supports the body's vital energy, and enhances the body's ability to resist pathogens and repair damage. Thus, it comprehensively alleviates pain caused by various factors, achieving the goals of promoting blood circulation, removing blood stasis, clearing the meridians, reducing inflammation and swelling, and relieving pain.

The application discloses a visual cleaning device for cleaning or medicine feeding of a human cavity such as a vagina or a rectum, which comprises a cleaning device shell, a cleaning assembly, a camera assembly and a flexible expansion assembly; the flexible expansion assembly comprises a plurality of flexible air bags arranged in a circumferential direction on a surface of an insertion end, and each flexible air bag is independently controlled by a control module, so that the flexible air bags are controllably contracted or expanded; on one hand, the flexible air bags in an expanded state are in flexible contact with an organ, so that the use comfort of the cleaning device is improved; on the other hand, the flexible air bags in a contracted state can form an avoiding space to avoid a wound surface; the camera assembly comprises a camera arranged at an end of the insertion end and is used for observing the inside of the cavity in real time. Through the cooperative design of the assemblies, the visual cleaning device realizes the functions of flexible expansion introduction of the cavity, visual accurate operation and selective wound surface avoiding, and mechanical damage to the human body is avoided, and the comfort of a patient is improved.

The present invention relates to a triazole compound having a novel ring structure, a preparation method therefor, and a use thereof. The triazole compound having a novel ring structure according to the present invention exhibits excellent ASK1 inhibiting ability and inhibits apoptosis of neurons, and thus can be used for the prevention or treatment of ASK1-related diseases, including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and liver diseases.

This invention provides a nanomaterial for relieving inflammation and pain in tendinopathy and its preparation method, relating to the field of biomedical technology. The nanomaterial comprises decellularized tendon DTM and hybrid membrane vesicles (MSM) of macrophages and nerve cells. The aforementioned nanomaterial for relieving inflammation and pain in tendinopathy includes decellularized tendon DTM and hybrid membrane vesicles (MSM) of macrophages and nerve cells. Combining these two components yields DTM-MSM, which regulates the proliferation and differentiation of tendon stem cells, modulates the local immune microenvironment, and relieves pain. It can improve inflammation and pain in tendinopathy and accelerate the repair of damaged tendons. In other words, DTM-MSM can not only alleviate the pathophysiological changes in tendinopathy but also rapidly improve the main clinical symptoms of tendinopathy, such as pain, swelling, and functional limitation, thus overcoming the current shortcomings of tendinopathy treatments, including slow onset of action, poor compliance, significant side effects, and unclear efficacy.

The utility model provides a positioning type water injection auxiliary device of a skin dilator, which comprises an injection pot, a first connecting piece, a second connecting piece and a water injection pipe, one side of the injection pot is connected with a connecting pipe, the other side of the injection pot is provided with a first connecting piece, and the upper surface of the injection pot is provided with a puncture hole; the auxiliary supporting assembly comprises a positioning base, a support and a needle head base, the positioning base is detachably connected with the first connecting piece, and the support is rotationally installed on the positioning base. According to the device, puncture of the puncture needle is limited through the auxiliary supporting assembly, it is guaranteed that the puncture needle can accurately puncture into a puncture hole, the risks of injection pot leakage, damage and treatment failure which are increased due to puncture needle failure are avoided, unnecessary pain is caused to a patient, meanwhile, the puncture needle can be fixed to a certain degree through the needle head base, and the puncture needle is fixed to a certain degree. The device is simple in structure and convenient to use, and meanwhile, the working difficulty of medical staff is reduced to a certain extent.

This utility model discloses an elastic biomimetic suction cup fixation patch, belonging to the field of medical technology. An elastic biomimetic suction cup fixation patch includes a substrate and multiple suction nozzles arranged in an array on the substrate. Each suction nozzle has multiple through grooves arranged in a ring at its opening, creating a wavy shape. This utility model, through the combined use of the substrate, suction nozzles, and anti-slip rings, can mimic the shape of an octopus suction cup to support and fix fistulas outside the patient's body, thus replacing traditional adhesive tape and chemical bonding. This avoids skin allergies and damage, preventing increased patient discomfort. The through grooves and ribs create a wavy opening for the suction nozzles, which adapts to the patient's skin texture, preventing air leakage and improving the patch's effectiveness.