7results about How to "Improve cognitive function" patented technology

The present application provides a kind of nutritional composition in the application of the product for improving learning, memory and cognitive ability.The nutritional composition includes animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose.Animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose can synergistically enhance the memory retention ability of the body, reduce the degree of learning and memory errors, and up-regulate the expression of oligodendrocyte transcription factor 2 coding gene, myelin basic protein coding gene and brain-derived neurotrophic factor coding gene, realize the double regulation of myelin formation and neurotrophic in hippocampus region of brain, synergistically improve the neural plasticity of central nervous system through gut-brain axis pathway, and then double improve the learning, memory and cognitive function of the body from the behavior and molecular level.

This invention relates to the field of ginseng extract technology, specifically to a composition containing ginseng extract and its preparation method. The provided composition containing ginseng extract comprises the following substances in parts by weight: 5-30 parts of a ginseng peptide composition with a molecular weight less than 3000 Da; 1-15 parts of a saponin composition composed of rare ginsenosides Rg3, Rg5, and Rh2; 3-10 parts of a ginseng polysaccharide-selenium nanocrystal composition; 1-5 parts of *Lactobacillus plantarum* P-8 lyophilized powder; 0.5-3 parts of sodium tanshinone; 3-20 parts of a prebiotic composition; and 0.1-5 parts of a vitamin composition. A method for preparing the aforementioned ginseng extract composition is also provided. The prepared ginseng extract composition exhibits excellent properties and has good application prospects.

The invention belongs to the field of biological medicine, and particularly relates to a medicine for preventing and treating Alzheimer disease, a target spot and a medicine screening method. The invention discloses the effect of the thyroid hormone T4 in treating the core target protein iodinated PP2A in neuropathy, and provides a technical basis for developing new medicines for preventing and treating neurodegeneration related diseases and monitoring the treatment effect of the related medicines. The thyroid hormone T4 can be used as a medicine for improving the memory and cognitive functions of a subject; the supplement of the thyroid hormone T4 can also be used for preventing and treating neurodegenerative related diseases, and a brand new medical application is provided for the thyroid hormone T4.

The present application provides the use of aucubin or the combination of aucubin and ACA in the preparation of a medicament for treating ischemic brain injury, in particular acute cerebral ischemia-reperfusion injury. The present application first discovers that aucubin or the combination of aucubin and ACA can increase the blood flow of the ischemic side after ischemic brain injury in mice; significantly reduce the cerebral infarction volume; improve the cognitive and motor function of mice after ischemic brain injury; reduce the degree of injury caused by cerebral ischemia, significantly improve the degree of neuronal necrosis of brain tissue after ischemia; significantly increase the survival rate of HT22 cells after oxygen-glucose deprivation and reperfusion injury, reduce intracellular Ca 2+ fluorescence intensity, and inhibit cell apoptosis.

The application discloses a multi-modal emotion regulation neural feedback training system and method, and relates to the field of computer-aided technology.The system comprises a pre-training subsystem and an online feedback subsystem; the pre-training subsystem is used for screening and extracting signal feature information from neural activity signals in an emotion regulation stage and for training a classifier for two-class activity mode classification; the online feedback subsystem is used for collecting neural activity data during the execution of emotion regulation activities and for real-time analysis of the category of current neural activity, while feedback recognition data and feedback training effects are presented in real time.The application extracts relevant complex feature patterns through multivariate pattern analysis, improves the training scheme related to individual emotion regulation neural activity through accurate targeting, and overcomes the limitations of traditional neural feedback technology in processing complex cognitive tasks, thereby improving the effectiveness of emotion regulation training and significantly improving the accuracy and personalization of feedback.

The present invention provides a cannabidiol derivative, a method for preparing same, and a composition for cognitive function improvement comprising same. The novel cannabidiol derivative of the present invention has been confirmed to exhibit acetylcholinesterase inhibitory activity and butyrylcholinesterase inhibitory activity, as well as inhibitory activity against monoamine oxidase B. Therefore, it is possible to simultaneously treat a decrease in acetylcholine levels in brain tissue and a decrease in blood butyrylcholine levels, which are seen in patients with dementia, and to provide a more effective cognitive function improvement treatment by preventing brain cell damage. Therefore, the cannabidiol derivative, the method for preparing same, and the composition for improving cognitive function comprising same, of the present invention, can be usefully used as a substance for improving cognitive function in the field of medicine and dietary supplement that can simultaneously inhibit acetylcholinesterase, butyrylcholinesterase, and monoamine oxidase B.

This invention discloses a method for regulating β-amyloid protein aggregation based on circularly polarized light and its application. The method includes electrostatically binding an amino-modified upconversion luminescent nanoparticle to a SiO2-coated chiral optically active nanostructure to obtain an upconversion chiral nanomaterial; coating the surface of the upconversion chiral nanomaterial with a biocompatible coating and a brain-targeting ligand, then mixing it with β-amyloid protein, and targeting the region with 5–100 mW / cm² light. 2 Irradiation with an 800–1400 nm laser for 15–30 min excites upconversion chiral nanomaterials to emit circularly polarized light. This circularly polarized light inhibits the aggregation of β-amyloid protein by interfering with the formation of its β-sheet conformation. This invention utilizes circularly polarized light (CPL) to induce changes in key protein site interactions, thereby altering the conformation of protein aggregation. This process is reversible and highly spatially selective. Animal experiments have verified that this method can effectively block Aβ aggregation and improve cognitive function.