19results about How to "Improve cognitive function" patented technology

The invention belongs to the field of pharmacy, and particularly relates to a 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone compound and application thereof. The compound is prepared through electrochemical driving under the conditions of no metal and no oxidizing agent, is a yellow solid, and gives a quasi-molecular ion peak [M + H] +: 397.0250 through a high-resolution mass spectrum. The invention relates to application of 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone in preparation of drugs for resisting the Alzheimer's disease and the Parkinson's disease, the 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone has a good effect on resisting the Alzheimer's disease and the Parkinson's disease, and the 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone can be used for preparing drugs for resisting the Alzheimer's disease and the Parkinson's disease. A novel medicine is provided for resisting the Alzheimer's disease and the Parkinson's disease.

The invention relates to an application of bifidobacterium breve i1088 or a postbiotic thereof in improvement of cognition. The bifidobacterium breve i1088 or the afterbiogen of the bifidobacterium breve i1088 is used for preparing a product for enhancing the oxidative stress capacity of mammalian cells, improving the in-vitro free radical scavenging level of mammals and changing at least one of the expression levels of mammalian cells Nrf2 and anti-oxidation related genes. The invention aims to explore the potential of the bifidobacterium breve in the aspect of improving the Alzheimer's disease and provide a safer and more effective nutritional supplement scheme for middle-aged and elderly people.

The invention discloses a head-mounted nerve stimulator capable of delaying and improving a cognitive function, and belongs to the technical field of brain nerve stimulation, the head-mounted nerve stimulator comprises a head-mounted earmuff worn on the head of a patient, one side of the middle part of the head-mounted earmuff is provided with an 808nm infrared light therapy device which is used for stimulating the brain of the patient and is adjustable in angle, and the other side of the head-mounted earmuff is provided with an infrared light source. A 40Hz light flickering device used for conducting visual stimulation on eyes of a patient is arranged in the eye protection device, and the device can stimulate the brain of the patient in the modes of 808nm infrared therapy, eye visual stimulation 40Hz light flickering, bone conduction accurate transmission 40Hz audio waves, transcranial magnetic stimulation and nasal olfactory stimulation. Gamma wave activity of the brain is promoted, cognitive performance, emotion balance and overall psychological health are improved, different stimulation effects are obtained through different stimulation modes, the clearing function of a brain lymphatic system is enhanced, brain performance of a patient is optimized, and sleep and cognition are greatly improved.

The invention discloses a silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold, a preparation method thereof and application of the silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold in TBI treatment, hyaluronic acid, silk fibroin and N-isopropylacrylamide are used as raw materials to construct temperature-sensitive hydrogel, and bone marrow mesenchymal stem cells (BMSCs) and paeoniflorin (PF) are loaded to form a treatment unit. Hyaluronic acid is one of components of an extracellular matrix (ECM), has high affinity to cells, and can promote proliferation of stem cells. Silk fibroin has high biocompatibility and biodegradability and good mechanical strength and ductility / toughness, and can promote tissue repair and stem cell attachment and proliferation. N-isopropylacrylamide endows the hydrogel with the characteristic of in-situ temperature-sensitive gelling. Therefore, the bioactive hydrogel stent has the advantages of components, combines the BMSCs and the PF, overcomes the obstacle that the medicine is limited by BBB to be transferred into the brain, and is implanted into a brain injury part after a TBI surgical operation to be used for repairing and treating nerve injury.

The embodiment of the invention discloses a cognitive function detection system, device and method for employment post-suitable training, and relates to the technical field of cognitive detection, and the method comprises a stimulation task matching module which is used for determining a plurality of corresponding current stimulation tasks in a stimulation task library through the industry demand information, which is obtained in advance, of the industry to which a practitioner belongs; the user data acquisition module is used for acquiring test reaction data of a test user in each current stimulation task and acquiring a physiological signal data set of the test user; the physiological psychological and cognitive function analysis module is used for determining a physiological psychological and cognitive function level corresponding to the test user according to the test reaction data and a preset neural network model, and determining an awakening state of the test user based on the physiological signal data set; and the training scheme generation module is used for generating a physiological psychological and cognitive function training scheme according to the corresponding physiological psychological and cognitive function level of the test user and the wake-up state of the test user.

The invention provides an application of a lactobacillus plantarum strain A21337 in preparation of a product for resisting anxiety and improving memory and concentration, and belongs to the technical field of biological medicines. Animal experiments show that the plant lactobacillus strain A21337 has the effects of resisting anxiety, resisting depression, improving cognitive impairment function and improving memory concentration, and a new means is provided for preventing and / or treating nerve diseases related to anxiety disorder, depression and cognitive impairment.

The invention relates to the technical field of medical biological detection, provides a new application of FCN2, particularly relates to an application of FCN2 as a target spot in screening or treating Alzheimer's disease, and further provides a kit for performing early screening or curative effect evaluation on Alzheimer's disease by utilizing quantitative detection aiming at FCN2 and a medicine taking the kit as the target spot. The kit and the detection method disclosed by the invention are simple, convenient, reliable, short in period, high in specificity and easy to clinically popularize. The liver-derived plasma protein Ficolin-2 (FCN2) can be used as an early screening target and a drug treatment target of the Alzheimer's disease (AD), is particularly used as a kit and other medical equipment products to be applied, and has important significance on early discovery, precise treatment, curative effect monitoring and the like of high-risk patients.

The present application provides a kind of nutritional composition in the application of the product for improving learning, memory and cognitive ability.The nutritional composition includes animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose.Animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose can synergistically enhance the memory retention ability of the body, reduce the degree of learning and memory errors, and up-regulate the expression of oligodendrocyte transcription factor 2 coding gene, myelin basic protein coding gene and brain-derived neurotrophic factor coding gene, realize the double regulation of myelin formation and neurotrophic in hippocampus region of brain, synergistically improve the neural plasticity of central nervous system through gut-brain axis pathway, and then double improve the learning, memory and cognitive function of the body from the behavior and molecular level.

This invention relates to the field of ginseng extract technology, specifically to a composition containing ginseng extract and its preparation method. The provided composition containing ginseng extract comprises the following substances in parts by weight: 5-30 parts of a ginseng peptide composition with a molecular weight less than 3000 Da; 1-15 parts of a saponin composition composed of rare ginsenosides Rg3, Rg5, and Rh2; 3-10 parts of a ginseng polysaccharide-selenium nanocrystal composition; 1-5 parts of *Lactobacillus plantarum* P-8 lyophilized powder; 0.5-3 parts of sodium tanshinone; 3-20 parts of a prebiotic composition; and 0.1-5 parts of a vitamin composition. A method for preparing the aforementioned ginseng extract composition is also provided. The prepared ginseng extract composition exhibits excellent properties and has good application prospects.

The invention relates to the technical field of neurology, in particular to a composition for treating brain injury and neurodegenerative lesion and application thereof, the composition is composed of an antioxidant and an anti-inflammatory drug, the antioxidant comprises vitamins, flavonoids, polysaccharides, saponins and active peptides according to the mass ratio of 4: 3: 1: 4: 2, and the content of the antioxidant is 60-80 parts; the anti-inflammatory drug comprises a non-steroidal anti-inflammatory drug NSAIDs, and the number of the components of the anti-inflammatory drug is 20-40 parts. By utilizing the synergistic effect of various active ingredients, the traditional Chinese medicine composition can comprehensively improve the symptoms of a patient, relieve pain, improve sleep and improve the cognitive function, thereby delaying neurodegenerative diseases and being beneficial to improving the functional state of neurons.

The invention relates to goat milk powder for improving sleep and enhancing memory and a preparation method thereof. The isomaltooligosacharide, the demineralized whey powder, the whey protein powder, the inulin, the compound vitamins, the compound minerals, the calcium carbonate and other components are added into the goat milk powder, so that the nutritional ingredients of the milk powder are improved, the nutrition is more comprehensive, in addition, the phosphatidylserine and the tea theanine are added, the functionality of the goat milk powder is improved, and the goat milk powder is more nutritional. The health-care tea is beneficial to improving the nerve cell function of a human body, enhancing memory, improving sleep, protecting neurons and improving the cognitive function. And the product is obtained by homogenizing and uniformly mixing the components, so that the functional improvement is realized, the market blank is effectively made up, and the requirements of consumers are met. The whole preparation process is simple, and the cost can be effectively reduced.

The invention discloses a Chinese medicine composition for slowing down brain degenerative lesions and its preparation method and application, which belongs to the field of medical technology, wherein the Chinese medicine composition includes the following components by weight: 15-20 parts of processed Polygonum multiflorum, 15-20 parts of Cistanche deserticola, 10-20 parts of Cornus officinalis, 10-18 parts of Chuanxiong, 15-22 parts of Polygala tenuifolia, 10-20 parts of Acorus calamus, 2-6 parts of Hirudo, 15-22 parts of Salvia miltiorrhiza, and 2-6 parts of ginger. Each component added by the present invention plays the effects of invigorating the kidney, promoting blood circulation and removing blood stasis, clearing phlegm, opening the orifices and dredging the meridians, relieving memory impairment, cognitive impairment, dull expression, taciturnity, vague speech, inexpressible words, sore waist, poor appetite, lack of breath and laziness, and has the effects of improving memory, improving cognitive function, regulating emotions, etc.

The invention belongs to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composition for treating vascular dementia and a using method thereof, and the traditional Chinese medicine composition comprises cassia twig, poria with hostwood, moutan bark, peach kernel, Chinese herbaceous peony, acorus calamus, polygala tenuifolia and ginseng. According to the traditional Chinese medicine composition for treating the vascular dementia and the use method thereof, the cognitive function and daily life ability of a patient with the vascular dementia can be obviously improved, the levels of serum cognitive related transmitters CGRP and 5-HT can be improved, and the levels of neuron apoptosis related factors such as BCL-2, Bax and Caspase-3 can be reduced. Results show that the blood stasis removing and resuscitation inducing prescription can improve the cognitive function and related factor level of the vascular dementia patient, and the advantage that the traditional Chinese medicine takes effect in multiple ways and multiple targets is exerted.

The invention belongs to the field of biological medicine, and particularly relates to a medicine for preventing and treating Alzheimer disease, a target spot and a medicine screening method. The invention discloses the effect of the thyroid hormone T4 in treating the core target protein iodinated PP2A in neuropathy, and provides a technical basis for developing new medicines for preventing and treating neurodegeneration related diseases and monitoring the treatment effect of the related medicines. The thyroid hormone T4 can be used as a medicine for improving the memory and cognitive functions of a subject; the supplement of the thyroid hormone T4 can also be used for preventing and treating neurodegenerative related diseases, and a brand new medical application is provided for the thyroid hormone T4.

The invention belongs to the field of new application of 4 '-O-methyl bavachalcone, and particularly relates to application of 4'-O-methyl bavachalcone in a medicine for treating vascular cognitive impairment. The invention discloses a new application of 4 '-O-methyl bavachalcone in development of drugs for treating vascular cognitive impairment for the first time, and the 4'-O-methyl bavachalcone is mainly used for effectively inhibiting inflammatory response of glial cells so as to improve symptoms of the vascular cognitive impairment. The preparation process of the medicine is simple and easy to implement, and the prepared medicine product is safe, stable and remarkable in curative effect and particularly has the pharmacological effects of repairing white matter damage, relieving neuroinflammation and the like.

The present application provides the use of aucubin or the combination of aucubin and ACA in the preparation of a medicament for treating ischemic brain injury, in particular acute cerebral ischemia-reperfusion injury. The present application first discovers that aucubin or the combination of aucubin and ACA can increase the blood flow of the ischemic side after ischemic brain injury in mice; significantly reduce the cerebral infarction volume; improve the cognitive and motor function of mice after ischemic brain injury; reduce the degree of injury caused by cerebral ischemia, significantly improve the degree of neuronal necrosis of brain tissue after ischemia; significantly increase the survival rate of HT22 cells after oxygen-glucose deprivation and reperfusion injury, reduce intracellular Ca 2+ fluorescence intensity, and inhibit cell apoptosis.

The application discloses a multi-modal emotion regulation neural feedback training system and method, and relates to the field of computer-aided technology.The system comprises a pre-training subsystem and an online feedback subsystem; the pre-training subsystem is used for screening and extracting signal feature information from neural activity signals in an emotion regulation stage and for training a classifier for two-class activity mode classification; the online feedback subsystem is used for collecting neural activity data during the execution of emotion regulation activities and for real-time analysis of the category of current neural activity, while feedback recognition data and feedback training effects are presented in real time.The application extracts relevant complex feature patterns through multivariate pattern analysis, improves the training scheme related to individual emotion regulation neural activity through accurate targeting, and overcomes the limitations of traditional neural feedback technology in processing complex cognitive tasks, thereby improving the effectiveness of emotion regulation training and significantly improving the accuracy and personalization of feedback.

The present invention provides a cannabidiol derivative, a method for preparing same, and a composition for cognitive function improvement comprising same. The novel cannabidiol derivative of the present invention has been confirmed to exhibit acetylcholinesterase inhibitory activity and butyrylcholinesterase inhibitory activity, as well as inhibitory activity against monoamine oxidase B. Therefore, it is possible to simultaneously treat a decrease in acetylcholine levels in brain tissue and a decrease in blood butyrylcholine levels, which are seen in patients with dementia, and to provide a more effective cognitive function improvement treatment by preventing brain cell damage. Therefore, the cannabidiol derivative, the method for preparing same, and the composition for improving cognitive function comprising same, of the present invention, can be usefully used as a substance for improving cognitive function in the field of medicine and dietary supplement that can simultaneously inhibit acetylcholinesterase, butyrylcholinesterase, and monoamine oxidase B.

This invention discloses a method for regulating β-amyloid protein aggregation based on circularly polarized light and its application. The method includes electrostatically binding an amino-modified upconversion luminescent nanoparticle to a SiO2-coated chiral optically active nanostructure to obtain an upconversion chiral nanomaterial; coating the surface of the upconversion chiral nanomaterial with a biocompatible coating and a brain-targeting ligand, then mixing it with β-amyloid protein, and targeting the region with 5–100 mW / cm² light. 2 Irradiation with an 800–1400 nm laser for 15–30 min excites upconversion chiral nanomaterials to emit circularly polarized light. This circularly polarized light inhibits the aggregation of β-amyloid protein by interfering with the formation of its β-sheet conformation. This invention utilizes circularly polarized light (CPL) to induce changes in key protein site interactions, thereby altering the conformation of protein aggregation. This process is reversible and highly spatially selective. Animal experiments have verified that this method can effectively block Aβ aggregation and improve cognitive function.