42results about How to "Improve cognitive function" patented technology

The invention discloses a comprehensive regulation and control method and system based on multi-mode electromagnetic and ultrasonic stimulation, and the method comprises the steps: collecting brain wave signals in real time through a multi-electrode EEG system, synchronously collecting skin electroreaction and heart rate variability signals, preprocessing the collected signals, and carrying out the feature extraction; the extracted signal features are subjected to multi-modal feature fusion through a CNN, and the multi-modal features are subjected to time sequence dependency analysis through a long-short-term memory network to generate a real-time emotional state quantization vector and identify a current emotional state category. Through synchronous acquisition and feature fusion of multi-electrode EEG, EDA and HRV signals, a real-time brain function connection network is constructed, accurate recognition and stimulation strategy making are performed on emotion regulation and control nodes based on graph theory analysis, the accuracy and reliability of emotion recognition are improved, personalized regulation and control of individual emotion states are realized, and the emotion regulation and control efficiency is improved. The cognitive function and language expression ability of an individual can be improved, and movement coordination disorder caused by emotional fluctuation is reduced.

The invention belongs to the field of pharmacy, and particularly relates to a 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone compound and application thereof. The compound is prepared through electrochemical driving under the conditions of no metal and no oxidizing agent, is a yellow solid, and gives a quasi-molecular ion peak [M + H] +: 397.0250 through a high-resolution mass spectrum. The invention relates to application of 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone in preparation of drugs for resisting the Alzheimer's disease and the Parkinson's disease, the 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone has a good effect on resisting the Alzheimer's disease and the Parkinson's disease, and the 2-(3-fluorophenyl)-3-(phenylseleno)-4H-pyridine-[1, 2-a] pyrimidine-4-ketone can be used for preparing drugs for resisting the Alzheimer's disease and the Parkinson's disease. A novel medicine is provided for resisting the Alzheimer's disease and the Parkinson's disease.

The invention relates to an application of bifidobacterium breve i1088 or a postbiotic thereof in improvement of cognition. The bifidobacterium breve i1088 or the afterbiogen of the bifidobacterium breve i1088 is used for preparing a product for enhancing the oxidative stress capacity of mammalian cells, improving the in-vitro free radical scavenging level of mammals and changing at least one of the expression levels of mammalian cells Nrf2 and anti-oxidation related genes. The invention aims to explore the potential of the bifidobacterium breve in the aspect of improving the Alzheimer's disease and provide a safer and more effective nutritional supplement scheme for middle-aged and elderly people.

The invention discloses a life history review multi-mode cognitive training method based on generative artificial intelligence. The method comprises the following steps: step 1, determining a cognitive state; step 2, pre-measuring; step 3, performing intervention; 4, intervention feedback and post-test are carried out; 5, comparing effects; 6, iterative optimization is carried out; according to the life history review multi-mode cognitive training method based on the generative artificial intelligence, the artificial intelligence technology is used for assisting intervention, the training effect can be improved, the personalized requirement can be met, the cognitive function of participating old people can be improved by stimulating self-propagated body memory, life integration and completion can be achieved, and the method is suitable for popularization and application. The life quality is improved, time convenience, place convenience and personnel convenience are achieved, selectivity and flexibility of service personnel are expanded, medicine taking and nerve stimulation are not involved, physiological invasiveness is avoided, and worries of intervention objects and family members of the intervention objects on side effects are reduced.

The invention discloses a head-mounted nerve stimulator capable of delaying and improving a cognitive function, and belongs to the technical field of brain nerve stimulation, the head-mounted nerve stimulator comprises a head-mounted earmuff worn on the head of a patient, one side of the middle part of the head-mounted earmuff is provided with an 808nm infrared light therapy device which is used for stimulating the brain of the patient and is adjustable in angle, and the other side of the head-mounted earmuff is provided with an infrared light source. A 40Hz light flickering device used for conducting visual stimulation on eyes of a patient is arranged in the eye protection device, and the device can stimulate the brain of the patient in the modes of 808nm infrared therapy, eye visual stimulation 40Hz light flickering, bone conduction accurate transmission 40Hz audio waves, transcranial magnetic stimulation and nasal olfactory stimulation. Gamma wave activity of the brain is promoted, cognitive performance, emotion balance and overall psychological health are improved, different stimulation effects are obtained through different stimulation modes, the clearing function of a brain lymphatic system is enhanced, brain performance of a patient is optimized, and sleep and cognition are greatly improved.

The invention discloses a silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold, a preparation method thereof and application of the silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold in TBI treatment, hyaluronic acid, silk fibroin and N-isopropylacrylamide are used as raw materials to construct temperature-sensitive hydrogel, and bone marrow mesenchymal stem cells (BMSCs) and paeoniflorin (PF) are loaded to form a treatment unit. Hyaluronic acid is one of components of an extracellular matrix (ECM), has high affinity to cells, and can promote proliferation of stem cells. Silk fibroin has high biocompatibility and biodegradability and good mechanical strength and ductility / toughness, and can promote tissue repair and stem cell attachment and proliferation. N-isopropylacrylamide endows the hydrogel with the characteristic of in-situ temperature-sensitive gelling. Therefore, the bioactive hydrogel stent has the advantages of components, combines the BMSCs and the PF, overcomes the obstacle that the medicine is limited by BBB to be transferred into the brain, and is implanted into a brain injury part after a TBI surgical operation to be used for repairing and treating nerve injury.

The invention provides application of circular RNA circRNA-APP. Experiments prove that interference of circRNA-APP can significantly reduce expression of hippocampal small proinflammatory factors TNF-alpha and IL-1beta of APP / PS1 TG mice, inhibit generation of A beta and tau phosphorylation, promote expression of anti-inflammatory factors IL-10, inhibit neuronal apoptosis, improve neuronal synaptic structure plastic damage and improve the cognitive function of the APP / PS1 TG mice. The results show that the interference circRNA-APP can inhibit neuroinflammation, thereby inhibiting neuronal apoptosis and synaptic injury, and further improving the cognitive function of AD mice. Therefore, the circular RNA circRNA-APP can serve as a target spot to be used for preparing the medicine for treating or preventing the neurodegenerative diseases, and a new thought is provided for research and development of the medicine for preventing and treating the neurodegenerative diseases including the Alzheimer's disease.

The embodiment of the invention discloses a cognitive function detection system, device and method for employment post-suitable training, and relates to the technical field of cognitive detection, and the method comprises a stimulation task matching module which is used for determining a plurality of corresponding current stimulation tasks in a stimulation task library through the industry demand information, which is obtained in advance, of the industry to which a practitioner belongs; the user data acquisition module is used for acquiring test reaction data of a test user in each current stimulation task and acquiring a physiological signal data set of the test user; the physiological psychological and cognitive function analysis module is used for determining a physiological psychological and cognitive function level corresponding to the test user according to the test reaction data and a preset neural network model, and determining an awakening state of the test user based on the physiological signal data set; and the training scheme generation module is used for generating a physiological psychological and cognitive function training scheme according to the corresponding physiological psychological and cognitive function level of the test user and the wake-up state of the test user.

The invention provides an application of a lactobacillus plantarum strain A21337 in preparation of a product for resisting anxiety and improving memory and concentration, and belongs to the technical field of biological medicines. Animal experiments show that the plant lactobacillus strain A21337 has the effects of resisting anxiety, resisting depression, improving cognitive impairment function and improving memory concentration, and a new means is provided for preventing and / or treating nerve diseases related to anxiety disorder, depression and cognitive impairment.

According to the application of the circular RNA circTrpc6 provided by the invention, experiments prove that the circTrpc6 is interfered, so that the cognitive function of SAMP8 can be improved, the hippocampal A beta expression and tau protein phosphorylation of SAMP8 mice can be obviously inhibited, the percentage of hippocampal neurons nissl bodies of the SAMP8 mice can be obviously reduced, and neuron damage can be alleviated; the number of hippocampal neuron branches, dendritic spine density and branch length of SAMP8 mice are obviously increased, and the shape plasticity of hippocampal synapses is improved. The results show that the circTrpc6 has potential treatment and prevention effects on tauopathy, dementia, AD (Alzheimer's disease) or other neurodegenerative diseases. Therefore, the circular RNA circTrpc6 can be used as a target spot for preparing the medicine for treating or preventing the neurodegenerative diseases.

The present invention belongs to the field of microbial technology, and specifically relates to the application of Akkermansia muciniphila in improving cognitive function. The present invention provides the application of Akkermansia muciniphila in improving cognitive function, and the Akkermansia muciniphila is deposited in CGMCC with a deposit number of CGMCC No.20955. The Akkermansia muciniphila can significantly improve cognitive function, increase the content of anti-inflammatory factors IL-4 and IL-10, significantly downregulate the expression of inflammatory factors and apoptosis factors, significantly upregulate the expression of Aβ degrading enzyme IDE, protect the normal morphology of the colon, and is non-toxic to the liver.

The invention discloses an application of intestinal microbial flora in preparation of a microecological preparation for treating gas explosion brain injury, and the neuroprotective effect of fecal microbial transplantation on GE-induced TBI rats, including neurological dysfunction, neuropathological change and neuroinflammation, is researched by adjusting a microflora-intestinal tract-brain axis. According to the invention, a model of intestinal flora imbalance and brain injury of male rats is established by using a fecal microbial transplantation technology, and then non-targeted metabonomics and microbial diversity analysis are carried out to explore bacteria with potential functions. Meanwhile, the intestinal microbiota composition, the intestinal and brain barrier functions and the number of regulatory T cells of the brain are evaluated. A potential anti-inflammatory mechanism determined by integrating microbiome and metabolome analysis relates to a peripheral immune pathway, and a promising strategy is provided for relieving GE-induced TBI.

The invention relates to the technical field of medical biological detection, provides a new application of FCN2, particularly relates to an application of FCN2 as a target spot in screening or treating Alzheimer's disease, and further provides a kit for performing early screening or curative effect evaluation on Alzheimer's disease by utilizing quantitative detection aiming at FCN2 and a medicine taking the kit as the target spot. The kit and the detection method disclosed by the invention are simple, convenient, reliable, short in period, high in specificity and easy to clinically popularize. The liver-derived plasma protein Ficolin-2 (FCN2) can be used as an early screening target and a drug treatment target of the Alzheimer's disease (AD), is particularly used as a kit and other medical equipment products to be applied, and has important significance on early discovery, precise treatment, curative effect monitoring and the like of high-risk patients.

The invention discloses application of GM1 in protection of nervous injury of developmental dogs caused by propofol anesthesia, and relates to the technical field of neuroprotective effect of GM1. The invention finds that the GM1 can relieve the hippocampus injury of a dog in the development period caused by propofol anesthesia and improve the cognitive function of the dog through anti-inflammatory, anti-pyroptosis and anti-oxidation effects, so that the neuroprotective effect is exerted; the GM1 can alleviate neuroinflammation, pyroptosis, oxidative stress and cognitive dysfunction of developmental dogs caused by propofol anesthesia by regulating a PI3K / Akt / NF-kappa B pathway and the expression of BDNF; 10 mg / kg of GM1 has a protective effect on nervous injury, caused by propofol anesthesia, of a developing-period dog, and has potential veterinary clinical application value.

The invention relates to the technical field of biological medicines, in particular to application of Ciliatoside A in preparation of a medicine for treating neurodegenerative diseases. Researches find that Ciliatoside A inhibits NLRP3 inflammasomes mediated by mitochondrial phagocytosis, reduces mitochondrial damage induced by oxidative stress, enables nerve cells to be less damaged by inflammatory substances, prevents or treats development of neurodegenerative diseases, and has a drug effect on treatment of Alzheimer's disease.

The invention provides an application of URB597 in preparation of a medicine for treating chronic traumatic encephalopathy. The URB597 inhibits neuronal ferroptosis through an endocannabinoid-ACSL4 axis so as to relieve cognitive impairment after CTE. The URB597 disclosed by the invention can inhibit the activity of fatty acid amide hydrolase and increase the level of endocannabinoid AEA in the brain, and the AEA has the capability of reducing neuronal ferroptosis by directly combining and interacting with 447-site serine (Ser447) of acyl coenzyme a synthetase long-chain family member 4 (ACSL4). The effect of remarkably improving the cognitive function of the chronic traumatic encephalopathy is reflected. Aiming at the effect of the URB597, the URB597 can be applied to preparation of medicines for treating chronic traumatic encephalopathy.

The present application provides a kind of nutritional composition in the application of the product for improving learning, memory and cognitive ability.The nutritional composition includes animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose.Animal bifidobacterium lactis subsp.CP-9 and 3'-sialyllactose can synergistically enhance the memory retention ability of the body, reduce the degree of learning and memory errors, and up-regulate the expression of oligodendrocyte transcription factor 2 coding gene, myelin basic protein coding gene and brain-derived neurotrophic factor coding gene, realize the double regulation of myelin formation and neurotrophic in hippocampus region of brain, synergistically improve the neural plasticity of central nervous system through gut-brain axis pathway, and then double improve the learning, memory and cognitive function of the body from the behavior and molecular level.

This invention relates to the field of ginseng extract technology, specifically to a composition containing ginseng extract and its preparation method. The provided composition containing ginseng extract comprises the following substances in parts by weight: 5-30 parts of a ginseng peptide composition with a molecular weight less than 3000 Da; 1-15 parts of a saponin composition composed of rare ginsenosides Rg3, Rg5, and Rh2; 3-10 parts of a ginseng polysaccharide-selenium nanocrystal composition; 1-5 parts of *Lactobacillus plantarum* P-8 lyophilized powder; 0.5-3 parts of sodium tanshinone; 3-20 parts of a prebiotic composition; and 0.1-5 parts of a vitamin composition. A method for preparing the aforementioned ginseng extract composition is also provided. The prepared ginseng extract composition exhibits excellent properties and has good application prospects.

The invention relates to the technical field of neurology, in particular to a composition for treating brain injury and neurodegenerative lesion and application thereof, the composition is composed of an antioxidant and an anti-inflammatory drug, the antioxidant comprises vitamins, flavonoids, polysaccharides, saponins and active peptides according to the mass ratio of 4: 3: 1: 4: 2, and the content of the antioxidant is 60-80 parts; the anti-inflammatory drug comprises a non-steroidal anti-inflammatory drug NSAIDs, and the number of the components of the anti-inflammatory drug is 20-40 parts. By utilizing the synergistic effect of various active ingredients, the traditional Chinese medicine composition can comprehensively improve the symptoms of a patient, relieve pain, improve sleep and improve the cognitive function, thereby delaying neurodegenerative diseases and being beneficial to improving the functional state of neurons.

The present invention provides a pharmaceutical composition for preventing and / or treating Alzheimer's disease and the use of the active ingredient combination therein in preparing a drug for preventing and / or treating Alzheimer's disease. The pharmaceutical composition of the present invention comprises two Chinese medicine monomers (i.e., (-)-donkey herbivorous phenol or a pharmaceutically acceptable salt thereof and caryophyllene or a pharmaceutically acceptable salt thereof) as active ingredients, and the two Chinese medicine monomers have been confirmed to have obvious synergistic effects in improving both the pathology of AD disease and the symptoms of AD disease, and because they may affect multiple different pathological processes, the pharmaceutical composition of the present invention is expected to become an effective multi-target, multi-pathway therapeutic drug for Alzheimer's disease, and has good clinical application prospects.

The invention relates to the technical field of food processing, and discloses yak milk powder helpful for promoting central nervous system development, and a preparation method of the yak milk powder comprises the following specific steps: S1, preparing raw materials; s2, performing primary pasteurization treatment; s4, directional superfine grinding; s5, performing precise segmented mixing; s6, carrying out double enzymolysis treatment and functional component integration; s7, performing multi-layer membrane filtration and refining; s8, low-temperature spray drying; s9, efficient freeze drying of probiotics; and S10, carrying out precise homogenization and aseptic packaging. The stability and activity of DHA (docosahexaenoic acid) and ARA (arachidonic acid) in the product are guaranteed through accurate proportioning and an optimized spray drying technology, and the components are important nutrient substances for brain and central nervous system development; the added phosphatidylserine and N-acetylneuraminic acid are key components of a neuronal membrane and can improve the activity of nerve cells and enhance the memory and cognitive function, so that the effect of promoting the development of the brain and the central nervous system can be achieved.

The invention provides a compound component for treating Alzheimer's disease and resisting aging and a preparation method thereof, and relates to the technical field of medicine preparation. The compound component mainly consists of six raw material medicines, namely a ginger extract, a herba cistanche extract, a radix salviae miltiorrhizae extract, a lucid ganoderma extract, a rhizoma polygonati extract and a liquorice root extract. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 10 to 20 parts of ginger extract, 20 to 40 parts of herba cistanche extract, 10 to 15 parts of radix salviae miltiorrhizae extract, 15 to 30 parts of lucid ganoderma extract, 5 to 10 parts of rhizoma polygonati extract, 3 to 5 parts of liquorice root extract and 5 to 10 parts of surfactant. According to the invention, the compound component can play a therapeutic role through a plurality of mechanisms, including oxidation resistance, inflammation resistance, neuroprotection, immunoregulation and the like, adopts natural medicinal components, is high in safety and small in side effect, can obviously improve cognitive function and improve memory, has an anti-aging effect, and can be used for preparing the traditional Chinese medicine composition. The aging process of an organism can be delayed.

The invention provides a nano-material for treating Alzheimer's disease by targeting cell aging, which is characterized in that the nano-material takes extracellular vesicles of a melanoma cell line as a nano-carrier to load curcumin. The pharmaceutical composition has the advantages of high bioavailability and good safety, and can be used as a medicine for clinically treating AD and related symptoms thereof.

The present invention discloses the use of STM2457 in the preparation of drugs for the prevention and treatment of Alzheimer's disease, and belongs to the field of biomedicine technology. In view of the problem that there is currently a lack of effective therapeutic drugs for Alzheimer's disease, the present invention finds that STM2457 inhibits Mettl3-mediated N6-adenylate methylation (m 6 A) modification level, thereby reducing the level of amyloid deposition, inhibiting neuroinflammatory response and improving cognitive function, can be used to prepare medicines or health foods for preventing and treating Alzheimer's disease or other neuroinflammatory related diseases. The present invention verifies the therapeutic effect of STM2457 in Alzheimer's disease model mice. STM2457 has an inhibitory effect on amyloid deposition and neuroinflammation in Alzheimer's disease model mice, and has an improving effect on learning and memory disorders in Alzheimer's disease model mice. STM2457 can significantly inhibit the production of amyloid deposition and reduce the level of neuroinflammation in Alzheimer's disease model mice, and significantly improve the cognitive memory disorders in Alzheimer's disease model mice.

The invention relates to goat milk powder for improving sleep and enhancing memory and a preparation method thereof. The isomaltooligosacharide, the demineralized whey powder, the whey protein powder, the inulin, the compound vitamins, the compound minerals, the calcium carbonate and other components are added into the goat milk powder, so that the nutritional ingredients of the milk powder are improved, the nutrition is more comprehensive, in addition, the phosphatidylserine and the tea theanine are added, the functionality of the goat milk powder is improved, and the goat milk powder is more nutritional. The health-care tea is beneficial to improving the nerve cell function of a human body, enhancing memory, improving sleep, protecting neurons and improving the cognitive function. And the product is obtained by homogenizing and uniformly mixing the components, so that the functional improvement is realized, the market blank is effectively made up, and the requirements of consumers are met. The whole preparation process is simple, and the cost can be effectively reduced.

The invention belongs to the technical field of medical auxiliary equipment, and discloses a square step training pad assembly for old people, which comprises a plurality of training pad bodies made of rubber materials, and the surfaces of the training pad bodies are square; the lower side of each training pad body is connected with four suckers, the upper side of each training pad body is connected with a green plush surface, and the surface of each plush surface is provided with a memory identifier. According to different memory identifiers (numbers, figures, colors, numbers and colors, figures and colors) arranged on each training pad body, the multiple training pad bodies are arranged and combined differently and are used for SSE of the old people, the cardiovascular system, musculoskeletal system and nervous system functions of the old people are effectively improved, the cognitive function is promoted, and the health of the old people is improved. The body function is improved; the mental health state is improved; and on the basis of not increasing the cost, the memory points are geometrically increased, and the cognitive function improvement efficiency and the exercise interestingness of the old people are improved.

The invention discloses a Chinese medicine composition for slowing down brain degenerative lesions and its preparation method and application, which belongs to the field of medical technology, wherein the Chinese medicine composition includes the following components by weight: 15-20 parts of processed Polygonum multiflorum, 15-20 parts of Cistanche deserticola, 10-20 parts of Cornus officinalis, 10-18 parts of Chuanxiong, 15-22 parts of Polygala tenuifolia, 10-20 parts of Acorus calamus, 2-6 parts of Hirudo, 15-22 parts of Salvia miltiorrhiza, and 2-6 parts of ginger. Each component added by the present invention plays the effects of invigorating the kidney, promoting blood circulation and removing blood stasis, clearing phlegm, opening the orifices and dredging the meridians, relieving memory impairment, cognitive impairment, dull expression, taciturnity, vague speech, inexpressible words, sore waist, poor appetite, lack of breath and laziness, and has the effects of improving memory, improving cognitive function, regulating emotions, etc.

The present disclosure relates to a blood flow increasing agent for the dorsal-lateral prefrontal cortex, which contains 6-methylsulfinylhexyl isothiocyanate.

The invention belongs to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composition for treating vascular dementia and a using method thereof, and the traditional Chinese medicine composition comprises cassia twig, poria with hostwood, moutan bark, peach kernel, Chinese herbaceous peony, acorus calamus, polygala tenuifolia and ginseng. According to the traditional Chinese medicine composition for treating the vascular dementia and the use method thereof, the cognitive function and daily life ability of a patient with the vascular dementia can be obviously improved, the levels of serum cognitive related transmitters CGRP and 5-HT can be improved, and the levels of neuron apoptosis related factors such as BCL-2, Bax and Caspase-3 can be reduced. Results show that the blood stasis removing and resuscitation inducing prescription can improve the cognitive function and related factor level of the vascular dementia patient, and the advantage that the traditional Chinese medicine takes effect in multiple ways and multiple targets is exerted.

The invention belongs to the field of biological medicine, and particularly relates to a medicine for preventing and treating Alzheimer disease, a target spot and a medicine screening method. The invention discloses the effect of the thyroid hormone T4 in treating the core target protein iodinated PP2A in neuropathy, and provides a technical basis for developing new medicines for preventing and treating neurodegeneration related diseases and monitoring the treatment effect of the related medicines. The thyroid hormone T4 can be used as a medicine for improving the memory and cognitive functions of a subject; the supplement of the thyroid hormone T4 can also be used for preventing and treating neurodegenerative related diseases, and a brand new medical application is provided for the thyroid hormone T4.