41 results about "Open field" patented technology

The invention discloses an application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction. An open field test and an elevated plus-maze test for researching anxiety behaviors as well as a tail suspension test and a forced swimming test for researching depression behaviors show that Activin A has a therapeutical effect on neurodegeneration diseases and can effectively relieve anxiety and depression behaviors induced by cocaine withdrawal, and further, Activin A almost does not have toxic and side effects on cells, has good development prospect and is expected to be developed into novel medicine for treating the neurodegeneration diseases, particularly the novel medicine for treating withdrawal symptoms after cocaine addiction.

The invention discloses a tree shrew behavior sensitization model evaluation method and an open field experiment device for the evaluation, the method comprises the following steps of: inducing the tree shrew behavior sensitization by METH, detecting the tree shrew behavior science, the motion distance, the speed and the track by an open field experiment, measuring the weight change of the tree shrew and marking plate behaviors; the invention also discloses an open field experiment device for evaluating the tree shrew behavior sensitization model, which comprises a box body, a bottom plate replacement box, a moving chassis, a fixing bracket and a camera, wherein the bottom of the moving chassis is provided with universal wheel with a brake, the box body is fixed on the top of the bottom plate replacement box, the bottom plate replacement box is fixed on the moving chassis, an upright post of the fixing bracket is fixed on the moving chassis, and the camera is fixed on the fixing bracket. The device provides reference and guidance for the success of establishing the tree shrew behavior sensitization model, and is convenient for researching the addiction mechanism of lazy drugs by means of the tree shrew behavior sensitization model; the open field experiment device can conveniently replace the bottom plate after each batch of experiments are finished, thereby reducing the time for cleaning, scraping, assembling and other processes.

The invention discloses a ConvLSTM network-based mouse open field experiment behavior analysis method. The method comprises the following steps: outputting a feature map containing mouse key point semantic information and position information by using a key point detection model; inputting a feature map sequence formed by adjacent frames into an identification classification model established based on a ConvLSTM network to realize behavior classification; and finally, correcting a misclassification result by using mode filtering so as to obtain behavior parameters in the mouse open field experiment. Automatic identification of animal behaviors and automatic calculation of animal behavior indexes are realized. The workload of researchers can be reduced, a quantitative behavior analysis method is provided for the researchers, and the objectivity of experiments is improved. Meanwhile, the refined behavior analysis method can help a researcher to capture some behavior modes which are difficult to perceive, and the reliability of an analysis result is improved. Meanwhile, compared with an existing mouse behavior recognition method, the method of the invention is higher in accuracy, is less affected by environment and illumination changes, and is higher in robustness.

The invention discloses application of phloretin in preparation of antidepressant drugs, and belongs to the technical field of medicines. A mouse depression model is established through chronic unpredictable mild stimulation, the anti-depression effect of the phloretin is evaluated through behavioral detection means such as an open field experiment, a sweet water preference experiment, a tail suspension experiment and a forced swimming experiment, and it is proved through an immunofluorescence experiment and ELISA kit detection that the phloretin can inhibit microglial cell activation; the compound can relieve neuroinflammation and play a neuroprotective role, and can be used for preparing anti-depression drugs.

The invention provides a table-based question and answer method, a device and computer equipment, and relates to the technical field of artificial intelligence, in particular to natural language treatment.The method comprises the steps of obtaining a plurality of question templates used for questioning information points in an information table, analyzing the received question information to obtain the part information of the question information; generating at least one replacement question semantically matched with the part information according to a plurality of question templates; responding to a selection operation on the at least one replacement question, and replying the selected replacement question according to information points in the information table; by analyzing the question information and combining the question template of the information table, the user is guided to select the replacement question and obtain the reply result of the selected replacement question, so that the method is simple and efficient, the strong correlation of the question information is ensured, the probability of accurately replying the question information is improved. Meanwhile, the method is suitable for the open field andlarge-scale table data .

The invention belongs to the technical field of behavior research, and particularly relates to a behavior detection device. An existing behavior detection device has the problems of training sugar reward smell interference, time consumption and individual learning ability difference, influences on insects are large, and insect conscious selection is needed, the existing behavior detection device is less suitable for insects. The invention provides a behavior detection device which comprises an open field, the open field is connected with a display screen, the display screen is connected with an intelligent terminal, and the intelligent terminal comprises a danger signal stimulation module; a camera is arranged in the open field; the open field is of an integrally-formed structure. The device can be used for untrained insects, so that the experiment time and cost are greatly saved, other factors such as sugar reward smell are reduced, the influence on an experiment object is reduced, and the consistency of experiment conditions is kept; through short-time stimulation and instinct contact operation, the obtained behavior data is of a subconscious level, and the priority of overall attribute perception can be better explained.

The invention belongs to the technical field of animal model preparation, and particularly relates to preparation method of a spaceflight depression syndrome animal model. The method comprises the steps of S1, spaceflight depression syndrome model molding, namely adopting closed isolated culture, simulated weightlessness, noise and circadian rhythms to verify the condition of accepting simulated spaceflight stress stimulation of adult SD male rats; and S2, spaceflight depression syndrome model behavioristics evaluation, namely detecting a depression syndrome state condition through a sweet water preference experiment, an open field experiment, a Morris water maze experiment, a step-down experiment and a forced swimming experiment. According to the simulated weightlessness manner, a Chen Jie improved tail crane is adopted, and an angle of 30 degrees is formed between the body and the horizontal plane; for day and night rhythm change, day and night alternation of space flight in 90 minutes in a light and shade period is simulated through light control; and for the step-down experiment, an electrified copper grid is laid at the bottom of a reaction box, animals are shocked by electricshock, and for a normal reaction, the animals jump onto an insulating platform in the box to avoid harmful stimulation. Through model establishment, the influence of different conditions on the depression syndrome of an astronaut is studied.

The invention provides novel application of bacteroides fragilis zwitterionic capsular polysaccharide or/and modified zwitterionic capsular polysaccharide. Mainly relates to application of the capsular polysaccharide extract of bacteroides fragilis in preparation of anti-anxiety drugs, the preservation number of the bacteroides fragilis is CGMCC NO.10685, and the capsular polysaccharide extract is an extract of capsular polysaccharide A. The invention further relates to application of the capsular polysaccharide extract of bacteroides fragilis in preparation of anti-anxiety drugs. Compared with the prior art, the invention has the following beneficial effects: the inventor of the invention finds that the capsular polysaccharide A extract of Bacteroides fragilis ZY312 has an obvious effect on anxiety disorder, and the effect is verified by carrying out elevated cross maze behavioral determination and open field experiments on a rat model.

The invention provides a method for preparing a neurodevelopmental defect rat model through treatment with 3-MA in a weaning period of rats, which comprises the following steps: performing intraperitoneal injection of an autophagy inhibitor 3-MA on the rats in a normal weaning period continuously for 7 days to prepare a rat model for inhibiting autophagy generation, and detecting autophagy generation through immunoblotting. Then verifying social barriers through a three-box social experiment, verifying whether the anxiety level of the rat model is increased through an open field experiment, an elevated cross labyrinth experiment and a black and white box experiment, verifying whether the rat model has memory impairment through a Y labyrinth experiment and a passive avoidance experiment, and performing Golgi body staining on the rat model and a control group; and the neuron and synaptic morphology of the hippocampus and the frontal lobe Through multiple experiments, it is found that in the weaning period, 3-MA treatment for preparing the rat model with the neurodevelopment defect has the advantages of being low in cost, short in modeling period, more obvious in model behavior abnormality and better in stability, and can be used for research of diseases such as schizophrenia and autism and research and development of new drugs.

The invention provides application of epilupinine (1-EPILLUPININE) and a derivative of the epilupinine (1-EPILLUPININE) in preparation of a medicine for treating depression. The application dosage is 0.01-30 mg of epilupinine or the derivative thereof per kilogram of body weight, and the anti-depression effect can be achieved within 60 minutes after administration. After the medicine is administrated for 5 days, the obvious anti-depression effect is generated in the low dosage and the high dosage. Research results show that in a mammal mouse tail suspension experiment, the epilupinine or the derivative thereof has a rapid anti-depression effect, and is more effective than a conventional anti-depression drug imipramine. According to the method, a forced swimming experiment and a mouse tail suspension experiment are adopted as drug screening experiments, and meanwhile, an Open field test is carried out, so that the autonomous activity of a mouse is detected, and interference of central excitants is avoided. The anti-depression drug has the advantages of being remarkable in anti-depression effect, quick in effect taking, small in dosage, small in side effect and the like, and is expected to become a new anti-depression drug which is quick, efficient and novel in mechanism.

The invention relates to application of single use of tenuigenin or combination of the tenuigenin and hydroxysafflor yellow A in preparation of a medicine for improving cognitive impairment after cerebral arterial thrombosis. Specifically, animal experiments find that when the tenuigenin is singly used or combined with hydroxysafflor yellow A, the movement distance and the number of times of passing through a central area in an MCAO rat open field experiment can be remarkably increased, the proportion of rapid movement time is increased, the proportion of rest time is reduced, the time of entering a dark box in an MCAO rat passive avoidance experiment is increased, and the specific value of P-JAK2/JAK2 and P-STAT3/STAT3 of the brain tissue of the MCAO rat and the expression of SOCS3 are improved. The invention provides a new medicine for preventing and treating cognitive impairment after cerebral arterial thrombosis.

The present application relates to the application of a mouse model in evaluating changes in intelligence level, the mouse model is a mouse model of high intelligence level, and the chromosomes of the mice in the high intelligence level mouse model include at least wild-type mice All or part of chromosome 1 from which the evaluation consists of performing a test selected from the group consisting of the Open Field Test, the Sugar Preference Test, the Water Maze Test, the Spatial Exploration Y-Maze Test, the Active Avoidance Y-Maze Test, and the Fatigue Spin-Rod Test .