Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
42 results about "Open field" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Developed by Calvin S. Hall, the open field test is an experimental test used to assay general locomotor activity levels, anxiety, and willingness to explore in animals (usually rodents) in scientific research. However, the extent to which behavior in the open field measures anxiety is controversial.
Application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction
InactiveCN104353059AImprove anxietyImprove depressive behaviorNervous disorderPeptide/protein ingredientsPharmaceutical drugNeuro-degenerative disease
The invention discloses an application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction. An open field test and an elevated plus-maze test for researching anxiety behaviors as well as a tail suspension test and a forced swimming test for researching depression behaviors show that Activin A has a therapeutical effect on neurodegeneration diseases and can effectively relieve anxiety and depression behaviors induced by cocaine withdrawal, and further, Activin A almost does not have toxic and side effects on cells, has good development prospect and is expected to be developed into novel medicine for treating the neurodegeneration diseases, particularly the novel medicine for treating withdrawal symptoms after cocaine addiction.
Owner:SOUTHERN MEDICAL UNIVERSITY
Gordon euryale seed extract with antioxidation and anti-ageing effects as well as preparation method and application thereof
InactiveCN102793754AAntioxidant is goodHigh content of active ingredientsOrganic active ingredientsAntinoxious agentsSolventChemistry
The invention discloses a gordon euryale seed extract with antioxidation and anti-ageing effects as well as a preparation method and application thereof. Through system optimization of an extraction solvent, an extracting method, an extraction method and a macroporous resin separation method, an optimal preparation process is obtained to prepare the gordon euryale seed extract. An experimental result shows that the gordon euryale seed extract provided by the invention is capable of obviously improving the motion capability and the exploratory behavior of a subacute ageing mouse in an open field, the academic record and memory ability of the mouse in water maze tests and the spleen and kidney indexes of the mouse, increasing the activity and protein contents of GSH-Px (Glutathione Peroxidase) and NOS (Nitric Oxide Synthase) in brain tissues, reducing the activity of AChE (acetylcholinesterase) in the brain tissues, improving the pathological change of the brain tissues, and having excellent antioxidation and anti-ageing effects.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Application of Xinnaoxin capsule in preparation of antidepressant
ActiveCN103494946AAntidepressantDoes not interfere with spontaneous activityNervous disorderCapsule deliverySynaptic cleftMedicine
The invention discloses application of a Xinnaoxin capsule in preparation of an antidepressant. According to experimental studies, the Xinnaoxin capsule can substantially reduce dead time during tail suspension and forced swimming of behavioral despair model mice; according to open field experiments, spontaneous activities of the mice are not influenced while dead time is substantially decreased, which prompts that the Xinnaoxin capsule has a certain anti-depression effect. Meanwhile, the Xinnaoxin capsule can substantially inhibit activity of monoamine oxidase and increase the content of a monoamine neurotransmitter in a synaptic cleft, which proves that the Xinnaoxin capsule has the anti-depression effect. Moreover, the Xinnaoxin capsule can substantially antagonize decrease of body temperature of the mice caused by reserpine and apomorphine and increase exogenous toxicity given to NE, which reveals that the capsule has the anti-depression effect. The anti-depression effect of the capsule is realized through improvement of the level of the monoamine neurotransmitter in the synaptic cleft.
Owner:GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
Global perceptual behavior detecting device and animal cognitive behavior testing method
ActiveCN110999798AEnsure consistencySmallAnimal housingOther apparatusAnimal behaviorPhysical medicine and rehabilitation
The invention provides a global perceptual behavior detecting device. The global perceptual behavior detecting device comprises an open field, a display screen, a shading part and an image pick-up part, wherein the open field is of a box body structure with an open top and is composed of a bottom plate and a plurality of side plates which are connected end to end through enclosing; the display screen is arranged at the top of the open field, a display surface of the display screen faces to the surface of the bottom plate of the open field, and dynamic approach images are displayed on the display screen and comprise either images maintaining topological attributes or images transforming the topological attributes; the shading part is arranged on the surface of the bottom plate of the open field and is provided with a shading space; and the image pick-up part is arranged on the open field and is used for monitoring dynamic behaviors in the open field in real time. The behavior detectingdevice is a subconscious visual-stimulation detecting device, can be used for testing influence on animal behaviors caused by subconscious topological perceptions and can be used for reflecting relevance between the animal behaviors and global attribute perceptions to certain extent. The invention further provides an animal cognitive behavior testing method.
Owner:SHENZHEN INST OF ADVANCED TECH
Medicament for treating tic disorder disease
InactiveCN103169871ASignificant effectNervous disorderMuscular disorderDiseaseRadix Rehmanniae Preparata
The invention relates to a medicament for treating tic disorder disease. The medicament is prepared from the following bulk drugs in parts by weight: 8-12 parts of cortex albiziae, 3-7 parts of rhizoma acori graminei, 6-8 parts of agrimonia pilosa, 3-5 parts of herba ardisiae japonicae, 8-15 parts of radix polygonati officinalis and 10-20 parts of radix rehmanniae praeparata. The medicament selects pure-natural traditional Chinese medicines, conforms to the assistance and guide principle of the traditional Chinese medicine according to the whole formula, and has obvious curative effects on stereotyped behaviors and open field activity through the pharmacological experimental verification.
Owner:太仓市胜舟生物技术有限公司
Tree shrew behavior sensitization model evaluation method and open field experiment device for evaluation
PendingCN109619029AEasy to replaceShort timeOrganic active ingredientsAnimal husbandryWeight changeComputer science
The invention discloses a tree shrew behavior sensitization model evaluation method and an open field experiment device for the evaluation, the method comprises the following steps of: inducing the tree shrew behavior sensitization by METH, detecting the tree shrew behavior science, the motion distance, the speed and the track by an open field experiment, measuring the weight change of the tree shrew and marking plate behaviors; the invention also discloses an open field experiment device for evaluating the tree shrew behavior sensitization model, which comprises a box body, a bottom plate replacement box, a moving chassis, a fixing bracket and a camera, wherein the bottom of the moving chassis is provided with universal wheel with a brake, the box body is fixed on the top of the bottom plate replacement box, the bottom plate replacement box is fixed on the moving chassis, an upright post of the fixing bracket is fixed on the moving chassis, and the camera is fixed on the fixing bracket. The device provides reference and guidance for the success of establishing the tree shrew behavior sensitization model, and is convenient for researching the addiction mechanism of lazy drugs by means of the tree shrew behavior sensitization model; the open field experiment device can conveniently replace the bottom plate after each batch of experiments are finished, thereby reducing the time for cleaning, scraping, assembling and other processes.
Owner:KUNMING MEDICAL UNIVERSITY
ConvLSTM network-based Mouse open field experiment behavior analysis method
ActiveCN113569675ARealize automatic identificationRealize automatic calculationCharacter and pattern recognitionNeural architecturesAnimal behaviorAlgorithm
The invention discloses a ConvLSTM network-based mouse open field experiment behavior analysis method. The method comprises the following steps: outputting a feature map containing mouse key point semantic information and position information by using a key point detection model; inputting a feature map sequence formed by adjacent frames into an identification classification model established based on a ConvLSTM network to realize behavior classification; and finally, correcting a misclassification result by using mode filtering so as to obtain behavior parameters in the mouse open field experiment. Automatic identification of animal behaviors and automatic calculation of animal behavior indexes are realized. The workload of researchers can be reduced, a quantitative behavior analysis method is provided for the researchers, and the objectivity of experiments is improved. Meanwhile, the refined behavior analysis method can help a researcher to capture some behavior modes which are difficult to perceive, and the reliability of an analysis result is improved. Meanwhile, compared with an existing mouse behavior recognition method, the method of the invention is higher in accuracy, is less affected by environment and illumination changes, and is higher in robustness.
Owner:ZHENGZHOU UNIV
Triad prediction model generation method and relationship triad extraction method and device
PendingCN112069818AImplement extractionNatural language data processingText database queryingAlgorithmData mining
The embodiment of the invention provides a triad prediction model generation method, a relationship triad extraction method and device. The triad prediction model generation method comprises the stepsof obtaining a training text containing a preset relationship triad; wherein the relationship triad comprises a main entity word, a relationship word and an auxiliary entity word; wherein the training text has auxiliary entity word annotation information and relationship word annotation information corresponding to the relationship triad; and training a preset model by taking the training text and the main entity words in the relationship triad as model input and taking the auxiliary entity word annotation information and the relationship word annotation information as model output to generate a triad prediction model. Therefore, relationship triples obtained through prediction can contain various different relation types, the number of the relationship triads which can be extracted by the triad prediction model and the relationship types are expanded, and extraction of the relation triads in the open field is achieved.
Owner:BEIJING SINOVOICE TECH CO LTD
Application of phloretin in preparation of antidepressant drug
PendingCN114191422AInhibition of activationRelieve neuroinflammationNervous disorderKetone active ingredientsElisa kitImmunofluorescence
The invention discloses application of phloretin in preparation of antidepressant drugs, and belongs to the technical field of medicines. A mouse depression model is established through chronic unpredictable mild stimulation, the anti-depression effect of the phloretin is evaluated through behavioral detection means such as an open field experiment, a sweet water preference experiment, a tail suspension experiment and a forced swimming experiment, and it is proved through an immunofluorescence experiment and ELISA kit detection that the phloretin can inhibit microglial cell activation; the compound can relieve neuroinflammation and play a neuroprotective role, and can be used for preparing anti-depression drugs.
Owner:NANTONG UNIVERSITY
Table-based question and answer method, device and computer equipment
PendingCN113535916AAccurate replyStrong correlationSemantic analysisText processingOpen domainSemantic matching
The invention provides a table-based question and answer method, a device and computer equipment, and relates to the technical field of artificial intelligence, in particular to natural language treatment.The method comprises the steps of obtaining a plurality of question templates used for questioning information points in an information table, analyzing the received question information to obtain the part information of the question information; generating at least one replacement question semantically matched with the part information according to a plurality of question templates; responding to a selection operation on the at least one replacement question, and replying the selected replacement question according to information points in the information table; by analyzing the question information and combining the question template of the information table, the user is guided to select the replacement question and obtain the reply result of the selected replacement question, so that the method is simple and efficient, the strong correlation of the question information is ensured, the probability of accurately replying the question information is improved. Meanwhile, the method is suitable for the open field andlarge-scale table data .
Owner:BEIJING BAIDU NETCOM SCI & TECH CO LTD
Behavior detection device
ActiveCN111034682AFacilitate path analysisPrevent drilling gapsTelevision system detailsColor television detailsInstinctSimulation
The invention belongs to the technical field of behavior research, and particularly relates to a behavior detection device. An existing behavior detection device has the problems of training sugar reward smell interference, time consumption and individual learning ability difference, influences on insects are large, and insect conscious selection is needed, the existing behavior detection device is less suitable for insects. The invention provides a behavior detection device which comprises an open field, the open field is connected with a display screen, the display screen is connected with an intelligent terminal, and the intelligent terminal comprises a danger signal stimulation module; a camera is arranged in the open field; the open field is of an integrally-formed structure. The device can be used for untrained insects, so that the experiment time and cost are greatly saved, other factors such as sugar reward smell are reduced, the influence on an experiment object is reduced, and the consistency of experiment conditions is kept; through short-time stimulation and instinct contact operation, the obtained behavior data is of a subconscious level, and the priority of overall attribute perception can be better explained.
Owner:SHENZHEN INST OF ADVANCED TECH
Oxidized isoaporphine alkaloid derivative as well as preparation method and anti-depression application thereof
ActiveCN114349700AMild reaction conditionsRaw materials are easy to getNervous disorderOrganic chemistryNeuroprotective DrugsAlkaloid
The invention discloses an oxidized isoaporphine alkaloid derivative with a structure as shown in a formula I, wherein R1 and R2 are independently selected from H, F, Cl and methoxyl respectively; and n is an integer of 2-6. An in-vitro activity experiment shows that the oxidized isoaporphine alkaloid derivative has relatively good protection activity on corticosterone-induced PC12 cell injury, which indicates that the corticosterone-induced PC12 cell injury has a neuroprotection function; in-vivo anti-depression drug effect evaluation shows that the oxidized isoaporphine alkaloid derivative can remarkably increase the moving distance and the moving speed in an open field experiment and remarkably shorten the immobility time in a tail suspension experiment and a forced swimming immobility experiment, which indicates that the oxidized isoaporphine alkaloid derivative can remarkably improve the depression state. The invention also discloses an application of the oxidized isoaporphine alkaloid derivative in preparation of an antidepressant drug. The invention also discloses an application of the oxidized isoaporphine alkaloid derivative in preparation of a neuroprotective drug.
Owner:CHINA PHARM UNIV
Preparation method of spaceflight depression syndrome animal model
The invention belongs to the technical field of animal model preparation, and particularly relates to preparation method of a spaceflight depression syndrome animal model. The method comprises the steps of S1, spaceflight depression syndrome model molding, namely adopting closed isolated culture, simulated weightlessness, noise and circadian rhythms to verify the condition of accepting simulated spaceflight stress stimulation of adult SD male rats; and S2, spaceflight depression syndrome model behavioristics evaluation, namely detecting a depression syndrome state condition through a sweet water preference experiment, an open field experiment, a Morris water maze experiment, a step-down experiment and a forced swimming experiment. According to the simulated weightlessness manner, a Chen Jie improved tail crane is adopted, and an angle of 30 degrees is formed between the body and the horizontal plane; for day and night rhythm change, day and night alternation of space flight in 90 minutes in a light and shade period is simulated through light control; and for the step-down experiment, an electrified copper grid is laid at the bottom of a reaction box, animals are shocked by electricshock, and for a normal reaction, the animals jump onto an insulating platform in the box to avoid harmful stimulation. Through model establishment, the influence of different conditions on the depression syndrome of an astronaut is studied.
Owner:63919 TROOPS PLA
Microwave irradiation device and method suitable for open field
ActiveCN109363795BAddress body anesthesiaAchieve real-time effectSurgical instrument detailsVeterinary instrumentsEngineeringLighting spectrum
Owner:SOUTHEAST UNIV
New application of bacteroides fragilis zwitterionic capsular polysaccharide or/and modified zwitterionic capsular polysaccharide
ActiveCN114699424ANo toxic side effectsOrganic active ingredientsNervous disorderRecurrent anxietyBacterosira
The invention provides novel application of bacteroides fragilis zwitterionic capsular polysaccharide or / and modified zwitterionic capsular polysaccharide. Mainly relates to application of the capsular polysaccharide extract of bacteroides fragilis in preparation of anti-anxiety drugs, the preservation number of the bacteroides fragilis is CGMCC NO.10685, and the capsular polysaccharide extract is an extract of capsular polysaccharide A. The invention further relates to application of the capsular polysaccharide extract of bacteroides fragilis in preparation of anti-anxiety drugs. Compared with the prior art, the invention has the following beneficial effects: the inventor of the invention finds that the capsular polysaccharide A extract of Bacteroides fragilis ZY312 has an obvious effect on anxiety disorder, and the effect is verified by carrying out elevated cross maze behavioral determination and open field experiments on a rat model.
Owner:GUANGZHOU ZHIYI PHARMA INC
Animal posture experiment system
The animal posture experiment system comprises an experiment device, the experiment device comprises a gait experiment module, a maze training module and an open field experiment module, and any one of the gait experiment module, the maze training module and the open field experiment module is selected for an experiment; the pressure monitoring device is used for collecting pressure information of the limb tail end of the animal to be experimented; the image monitoring device is used for shooting posture image information of the to-be-experimented animal in the experimental device; the electrophysiological signal monitoring device is used for collecting electroencephalogram information of the animal to be experimented and applying an electrical stimulation signal to the animal to be experimented; the processing device is used for acquiring the electroencephalogram information, the pressure information and the posture image information. According to the animal posture experiment system, the gait experiment module, the labyrinth training module and the open field experiment module are arranged to obtain the pressure information, the posture image information and the electroencephalogram information of the animal to be experimented, comprehensive analysis in multiple aspects can be achieved, and therefore the accuracy of the analysis result is improved.
Owner:北京宁矩科技有限公司
Method for preparing neurodevelopmental defect rat model through 3-MA treatment in weaning period of rats
The invention provides a method for preparing a neurodevelopmental defect rat model through treatment with 3-MA in a weaning period of rats, which comprises the following steps: performing intraperitoneal injection of an autophagy inhibitor 3-MA on the rats in a normal weaning period continuously for 7 days to prepare a rat model for inhibiting autophagy generation, and detecting autophagy generation through immunoblotting. Then verifying social barriers through a three-box social experiment, verifying whether the anxiety level of the rat model is increased through an open field experiment, an elevated cross labyrinth experiment and a black and white box experiment, verifying whether the rat model has memory impairment through a Y labyrinth experiment and a passive avoidance experiment, and performing Golgi body staining on the rat model and a control group; and the neuron and synaptic morphology of the hippocampus and the frontal lobe Through multiple experiments, it is found that in the weaning period, 3-MA treatment for preparing the rat model with the neurodevelopment defect has the advantages of being low in cost, short in modeling period, more obvious in model behavior abnormality and better in stability, and can be used for research of diseases such as schizophrenia and autism and research and development of new drugs.
Owner:河南省精神病医院
An Open-Domain Question Answering Method Based on Hypothetical Semi-Supervised Learning
ActiveCN108717413BAvoid missingFully learnDigital data information retrievalNeural learning methodsManual annotationOpen domain
The invention discloses an open domain question answering method based on hypothetical semi-supervised learning, including: (1) using information retrieval technology to extract articles related to the question from a corpus; (2) assuming that a given question answering training set comes with The article is the only positive label, and all articles extracted from the corpus are negative labels; (3) Construct a deep learning model, learn the characteristics of positive labels by training an article scorer, and train a reader to select the correct answer from the article ;(4) Perform correlation ranking of articles, send the first n articles with high correlation into the scorer for scoring and re-label according to the scores; (5) Repeat steps 3 and 4 until the model converges; (6) Model training After that, the open domain question answering application is performed. The invention can greatly improve the quality of article extraction and the accuracy of answers in the existing open domain question answering system without relying on additional manual annotation and external knowledge.
Owner:ZHEJIANG UNIV
A behavior detection device for overall perception and a method for testing cognitive behavior of animals
ActiveCN110999798BEnsure consistencySmallAnimal housingOther apparatusAnimal behaviorPhysical medicine and rehabilitation
The present invention provides a behavior detection device for overall perception, comprising: an open field, which is a box structure with an open top, and the open field is surrounded by a bottom plate and a plurality of side plates connected end to end; a display screen, It is arranged on the top of the open field, the display surface of the display screen faces the bottom plate surface of the open field, and a dynamic approaching image is displayed on the display screen, and the dynamic approaching image includes an image maintaining topological properties and transforming topological properties at least one of the images; the shielding part is arranged on the bottom plate surface of the open field, and the shielding part is provided with a shielding space; the camera part is arranged on the open field for real-time monitoring of the open field Dynamic. The behavior detection device is a subconscious visual stimulus detection device, which can be used to test the influence of subconscious topology perception on animal behavior, and can reflect the correlation between animal behavior and overall attribute perception to a certain extent. The invention also provides a method for testing animal cognitive behavior.
Owner:SHENZHEN INST OF ADVANCED TECH
Application of epilupinine and derivative thereof in preparation of medicine for treating depression
ActiveCN114652720AAntidepressant fastGuaranteed reliabilityOrganic active ingredientsNervous disorderSide effectEfficacy
The invention provides application of epilupinine (1-EPILLUPININE) and a derivative of the epilupinine (1-EPILLUPININE) in preparation of a medicine for treating depression. The application dosage is 0.01-30 mg of epilupinine or the derivative thereof per kilogram of body weight, and the anti-depression effect can be achieved within 60 minutes after administration. After the medicine is administrated for 5 days, the obvious anti-depression effect is generated in the low dosage and the high dosage. Research results show that in a mammal mouse tail suspension experiment, the epilupinine or the derivative thereof has a rapid anti-depression effect, and is more effective than a conventional anti-depression drug imipramine. According to the method, a forced swimming experiment and a mouse tail suspension experiment are adopted as drug screening experiments, and meanwhile, an Open field test is carried out, so that the autonomous activity of a mouse is detected, and interference of central excitants is avoided. The anti-depression drug has the advantages of being remarkable in anti-depression effect, quick in effect taking, small in dosage, small in side effect and the like, and is expected to become a new anti-depression drug which is quick, efficient and novel in mechanism.
Owner:BEIJING ANDING HOSPITAL CAPITAL MEDICAL UNIV +1
An open-field test box convenient for multiple experiments
The invention provides an open field test case facilitating repeated tests. The open field test case comprises a case body device and a rotary supporting device. The case body device comprises a case body frame and baffles, sealing plates are fixedly installed on the left face and the right face, opposite to each other, of the case body frame respectively, and the baffles are hinged to three optional faces in the upper face, the lower face, the front face and the rear face of the case body frame respectively. The sealing plates are provided with rotary protrusions which are rotationally installed on the rotary supporting device. The side faces, in the thickness direction, of the baffles are provided with protrusions, and the frame is provided with clamping grooves matched with the protrusions. The open field test case is simple in structure; besides, the open field test case can be used in repeated tests, shortening unnecessary time spent on tests.
Owner:NINGBO NO 2 HOSPITAL
A method for analyzing the movement behavior of mice in open field experiments based on key point detection
ActiveCN113470077BEliminate measurement errorsImprove robustnessImage enhancementImage analysisField experimentNasal tip
The invention discloses a method for analyzing the movement behavior of mice in an open field experiment based on key point detection, comprising: (a) collecting experimental videos and determining the experimental area; (b) a mouse key point detection model based on a convolutional neural network, Detect the nose tip, left ear, right ear and tail root of the mouse in the video image, and return the coordinates of the key points; (c) calculate the movement distance of the key points between adjacent frames, and filter out the abnormal key points with the distance threshold; (d) check the key points The coordinates are cleaned, and the Kalman filter is used to predict the trajectory to eliminate the influence of measurement errors; (e) determine the movement parameters in the mouse open field experiment from the calculated key point coordinates, and generate relevant graphical reports. The method for analyzing the movement behavior of mice in open-field experiments based on key point detection in the present invention has strong robustness, and has strong anti-interference ability against changes in the environment and light, and greatly simplifies the process of analyzing behavioral indicators. Behavioral analysis means are convenient, comprehensive and precise.
Owner:郑州布恩科技有限公司
A kind of Lactobacillus brevis capable of alleviating anxiety and improving sleep and its application
ActiveCN110157647BExtension of timeIncrease the number of times you enter the open armsMilk preparationNervous disorderCell adhesionSleep Latencies
The invention discloses Lactobacillus brevis capable of relieving anxiety and improving sleep and its application, belonging to the technical field of microbes. Lactobacillus brevis GDMCC No.60605 of the present invention has excellent ability to simulate gastrointestinal tract survival, cell adhesion and GABA production. In the open field test, it can significantly increase the frequency of mice entering the central area, and prolong the time of mice in the central area of the open field without affecting the total movement distance of mice; in the elevated plus maze test, it can significantly increase the number of mice entering the open arm. times; it can prolong the sleep time induced by pentobarbital sodium and shorten the sleep latency induced by barbital sodium; it can regulate the intestinal flora and significantly increase the relative abundance of Allobaculum in the intestinal tract of mice. The Lactobacillus brevis GDMCC No. 60605 is used to prepare pharmaceutical compositions and fermented foods for relieving anxiety and improving sleep, and has very broad application prospects.
Owner:JIANGNAN UNIV
Application of single use of tenuigenin or combination of tenuigenin and hydroxysafflor yellow A in preparation of medicine for improving cognitive impairment after cerebral arterial thrombosis
ActiveCN113350358AIncrease distanceIncrease the number of passes through the central areaOrganic active ingredientsNervous disorderPassive avoidancePharmaceutical drug
The invention relates to application of single use of tenuigenin or combination of the tenuigenin and hydroxysafflor yellow A in preparation of a medicine for improving cognitive impairment after cerebral arterial thrombosis. Specifically, animal experiments find that when the tenuigenin is singly used or combined with hydroxysafflor yellow A, the movement distance and the number of times of passing through a central area in an MCAO rat open field experiment can be remarkably increased, the proportion of rapid movement time is increased, the proportion of rest time is reduced, the time of entering a dark box in an MCAO rat passive avoidance experiment is increased, and the specific value of P-JAK2 / JAK2 and P-STAT3 / STAT3 of the brain tissue of the MCAO rat and the expression of SOCS3 are improved. The invention provides a new medicine for preventing and treating cognitive impairment after cerebral arterial thrombosis.
Owner:SHANGHAI PUTUO DISTRICT CENT HOSPITAL
Kit for detecting rat peripheral blood HDAC5 expression level, and use method of kit
PendingCN112342281AHighlight substantiveSignificant progressMicrobiological testing/measurementPhysiologyAdolescent offspring
The invention provides a kit for detecting a rat peripheral blood HDAC5 expression level, and a use method of the kit. Through the kit, a pregnant infection adolescent offspring rat of which the peripheral blood monocyte HDAC5 expression quantity is obviously up-regulated is screened to be continuously raised to an adult stage to carry out behavior detection (an open field test, a Y maze experiment and prepulse inhibition (PPI)). A result shows that the adult stage of the rat of which the HDAC5 obviously rises is obviously abnormal, for example, an anxiety level is increased, memory deficits are in the presence, sensory gating dysfunctions are in the presence and the like. Therefore, on the basis of the above inference, the kit can effectively evaluate the model quality of a pregnant infection adolescent offspring and can be used for subsequent researches.
Owner:河南省精神病医院
Use of Mouse Models in Assessing Intelligence Levels
The present application relates to the application of a mouse model in evaluating changes in intelligence level, the mouse model is a mouse model of high intelligence level, and the chromosomes of the mice in the high intelligence level mouse model include at least wild-type mice All or part of chromosome 1 from which the evaluation consists of performing a test selected from the group consisting of the Open Field Test, the Sugar Preference Test, the Water Maze Test, the Spatial Exploration Y-Maze Test, the Active Avoidance Y-Maze Test, and the Fatigue Spin-Rod Test .
Owner:GEMPHARMATECH CO LTD
A method to assess the effects of musical stimulation on weaned piglets
The invention provides a method for evaluating the influence of musical stimulation on weaned piglets, belonging to the field of animal husbandry. The purpose of the present invention is to judge the influence of music on the emotional response of weaned piglets. The invention provides a method for evaluating the influence of musical stimulation on weaned piglets. First, the weaned piglets are treated. One group plays classical music Mozart K.448, and the loudness is positioned at 60-70dB. The noise loudness was 80‑85dB. One group did not perform musical intervention on the piglets, and the sound loudness range was 20‑40dB. The weaned piglets were subjected to an open field test for 5 minutes, followed by a novelty test for 5 minutes, and finally the behavior of all weaned piglets was counted. To explore whether classical music can improve the positive emotions of piglets, and whether environmental background noise has a negative impact on piglets, to provide a theoretical basis for the application of music in production practice to improve animal welfare and health.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
An open field experiment data analysis method, system and terminal equipment
ActiveCN110599520BQuick drawDrawn preciselyImage enhancementImage analysisPattern recognitionComputer graphics (images)
Owner:SHENZHEN INST OF ADVANCED TECH
Modeling and evaluation method for mice with depression and liver depression fire syndrome
ActiveCN114391507AShort modeling timeSimple and fast operationAnimal husbandryDiseaseLight irradiation
The invention discloses a modeling method for mice suffering from depression and liver depression fire syndrome diseases, and relates to the field of animal model construction methods, the modeling method comprises the following steps: performing continuous sleep deprivation stimulation on healthy mice for 2-30 days, and simultaneously performing light irradiation daily stimulation and next-day grain stimulation every day, the obtained model mouse has symptomatic manifestation of depression, and meanwhile, the characteristic that the model has the syndrome of liver depression transforming into fire is judged through a traditional Chinese medicine syndrome diagnosis method. The depression mouse model established by the invention not only has clinical liver depression transforming into fire and depression states in general signs, but also can be used for treating depression through weight, total distance of open field activities, time, times and average speed of entering the center of the open field, times and time of entering an open arm in an elevated cross labyrinth, water intake and forced swimming immobile time. The model accords with the characteristics of liver depression transforming into fire in traditional Chinese medicine, and can be used for further research on pathogenesis and treatment of the syndrome of liver depression transforming into fire of depression.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
A kind of traditional Chinese medicine composition for treating depression and preparation method thereof
ActiveCN104116836BSignificant antidepressant effectGood effectNervous disorderPlant ingredientsSide effectPharmaceutical Substances
The invention relates to a traditional Chinese medicine composition capable of treating depression and a preparation method thereof. The effective components of the medicine are composed of Chinese jujube, Atractylodes macrocephala, dodder, rehmannia glutinosa, tangerine peel and honeysuckle, and the weight ratio of each traditional Chinese medicine is 5-10 in sequence. :5~15:3~5:10~15:5~10:5~15. The traditional Chinese medicine composition can be used for treating depression. The experimental results show that jujube, Atractylodes macrocephala, dodder, rehmannia glutinosa, tangerine peel and honeysuckle are compounded in a certain proportion, which can increase the number of parallel moving grids and upright times of depressed mice in the open field test; increase the number of depression mice. Hedonic behavior index and body weight have good antidepressant effect, significant effect and few side effects; and the raw materials are easy to obtain, and can be made into tablets, capsules and pills by conventional methods, and the preparation method is simple, safe, effective and economical .
Owner:XINXIANG MEDICAL UNIV
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com