265 results about "Hippocampus" patented technology

The invention relates to the technical field of biology, in particular to multifunctional belly-expanding hippocampal peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The hippocampus antioxidative peptide is prepared by adopting an ultrahigh pressure pretreatment and enzymolysis technology, the adopted extraction process is simple in route, and the time and the production cost are effectively saved; an animal model is utilized to prove the anti-oxidation effect and the effect of improving male reproductive disorder and testis injury of the multifunctional belly-expanding hippocampal peptide; and on the basis, a novel peptide fragment with high activity, no toxicity and no sensitization is obtained.

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application of the swelling hippocampal peptide in preparation of anti-fatigue products. Five active peptide sequences with high biological activity are obtained through research, animal behavioral experiments prove that the belly distention hippocampal peptide has a remarkable anti-fatigue effect and can prolong the swimming exhaustion time and enhance the muscle strength, the anti-fatigue effect of the belly distention hippocampal peptide is verified, and a new way is provided for development of anti-fatigue hippocampal products.

The invention relates to the technical field of intelligent aquaculture and automatic processing, in particular to an appearance characteristic-based hippocampus intelligent grading and pond-dividing culture method and system, and the method comprises the following steps: S1, collecting sparse visual data and multi-source physiological data of hippocampus; s2, generating a three-dimensional digital twinborn model based on the sparse visual data; calculating a growth state grading index based on the three-dimensional digital twinborn model; s3, calculating a physiological stress index based on the multi-source physiological data; s4, comparing the physiological stress index calculated in real time with a preset safety stress threshold value and a critical stress threshold value, and generating a hierarchical adaptive correction strategy; s5, according to a grading self-adaptive correction strategy, controlling a flexible mechanical arm to execute fishing and pond separation operation; according to the method, the appearance and physiological data of the hippocampus are synchronously collected in a non-contact mode, the technical problems that the real condition of the hippocampus cannot be evaluated and damage is possibly caused due to target stress response caused by traditional physical intervention are solved, and the authenticity and effectiveness of original data are guaranteed.

The invention discloses an Alzheimer disease risk prediction method based on feature fusion, a medium and equipment. The method comprises the following steps: firstly, acquiring an sMRI image, an FDG-PET image, a biomarker and intelligence score data of a target subject; then, sMRI and FDG-PET image data are respectively input into a three-dimensional convolutional neural network module, and a corresponding first image feature map and a corresponding second image feature map are extracted; secondly, inputting the two feature maps into a cross attention fusion module to obtain image fusion features; and inputting a U-shaped up-sampling network to segment a hippocampus region to obtain hippocampus features. And then, merging the image fusion features, the hippocampus features, the biomarker data and the intelligence score data, and inputting the merged data into an extreme learning machine for calculation, thereby obtaining an onset risk prediction result of the Alzheimer's disease. According to the method, by means of cross-modal data fusion, multi-modal data complementary information is extracted, and the accuracy of onset risk prediction can be effectively improved.

The invention relates to the technical field of grinding and crushing, and discloses hippocampus active mucoprotein grinding equipment and an extraction technology.The hippocampus active mucoprotein grinding equipment comprises a shell, a motor is fixedly installed at the bottom of the shell, a driving shaft is fixedly installed at the output end of the top of the motor, and a primary grinding assembly is detachably installed at the top end of the driving shaft; a secondary grinding assembly is fixedly installed on the circumferential face of the upper half portion of the driving shaft, an annular sieve tray is fixedly installed on the inner wall of the middle of the shell, and a vibration assembly is arranged on the surface of the driving shaft. The shoveling plate is driven by the rotating cover to move at the top of the annular screening disc, hippocampus on the bottom layer of the annular grinding groove is thrown upwards, the hippocampus enters the space between the hollow rotating roller and the outer convex ring and the space between the hollow rotating roller and the inner convex ring, and the hollow rotating roller rotates while moving along the annular grinding groove. The outer wall of the hollow rotating roller is matched with the outer convex ring and the inner convex ring to extrude and crush the hippocampus, so that secondary grinding of the hippocampus is realized; therefore, the purposes of grinding the hippocampal tissue twice and improving the grinding efficiency are achieved.

The invention relates to the technical field of biology, in particular to a swelling hippocampal peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The hippocampus antioxidative peptide is prepared by adopting an ultrahigh pressure pretreatment and enzymolysis technology, the adopted extraction process is simple in route, and the time and the production cost are effectively saved; an animal model is utilized to prove the antioxidation effect and the effect of improving male reproductive disorder and testis injury of the hippocampal swelling peptide; and on the basis, a novel peptide fragment with high activity, no toxicity and no sensitization is obtained.

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application thereof in preparation of uric acid reducing and gout resisting products. The amino acid sequence is shown as SEQ ID NO.1-5. The uric acid reducing effect is verified by adopting an in-vitro XOD inhibition experiment and a cell experiment; furthermore, the uric acid reducing and gout resisting activity of the compound is verified through a hyperuricemia animal model, and a theoretical basis is provided for high-valued utilization of the belly-swelling hippocampus and development of uric acid reducing and gout resisting products.

The invention belongs to the technical field of preparation of peptides, and relates to a hippocampus polypeptide and application thereof. The amino acid sequence of the hippocampus polypeptide is shown as SEQ ID NO.1 in a sequence table. The hippocampus polypeptide provided by the invention has excellent anti-hypoxia activity, and by virtue of the characteristic, the hippocampus polypeptide can be used as an active component to be added into food, beverage or dietary supplement to prepare functional food or health care products for daily use of specific people so as to enhance tolerance to an anoxic environment.

The invention belongs to the technical field of marine biological medicines, and relates to a hippocampus polypeptide for improving cognitive impairment of Alzheimer's disease and a preparation method and application thereof.The preparation method comprises the steps that hippocampus powder is dissolved in water, the pH value is adjusted to 1.8-2.5, pepsin is added for oscillation incubation for 2 hours, and then high-temperature heating is conducted to inactivate enzyme; adjusting the pH value to 7.3-8.0, adding chymotrypsin to form a compound enzyme enzymolysis combination, oscillating and incubating for 2 hours, and heating at high temperature to inactivate the enzyme; centrifuging the solution, collecting enzymatic hydrolysate, and filtering the obtained hippocampus crude polypeptide through an ultrafiltration membrane to obtain molecular weight lt; the hippocampus polypeptide is subjected to vacuum freeze drying and preservation. The hippocampus polypeptide extracted and prepared from hippocampus japonicus by adopting a biological enzymolysis method has excellent APP inhibitory activity, can remarkably improve dysmnesia, and can be used for developing related functional foods or medicines for treating Alzheimer's disease.

The utility model relates to the technical field of rivets, in particular to a hippocampus rivet, which comprises a rivet core and a rivet shell, the rivet core comprises a rivet head, a riveting section, a snapping section and a rivet rod, the peripheral surface of the riveting section is provided with a first annular convex pattern and vertical convex teeth, the first annular convex pattern is arranged at the upper part of the riveting section in a surrounding manner, and the vertical convex teeth are arranged at the lower part of the riveting section. The vertical convex teeth are distributed on the lower portion of the riveting section at intervals in the circumferential direction of the riveting section, and the first annular convex lines and the vertical convex teeth all protrude out of the outer wall face of the riveting section; the nail shell comprises a nail shell body and a nail cap, and through holes are formed in the nail shell body and the nail cap in a penetrating mode. Through mutual cooperation of the first annular convex lines and the vertical convex teeth, tight engagement of the rivet core and the inner wall of the rivet shell can be achieved, the locking force of the rivet core is improved, axial movement and circumferential rotation of the rivet core in the rivet shell can be limited after riveting, the rivet core is effectively prevented from loosening and falling off, the connection strength between riveted workpieces is guaranteed, and the service life of the rivet core is prolonged. The technical problems that an existing hippocampus rivet core is insufficient in locking force, and the rivet core is prone to loosening and falling off after riveting are solved.

Compositions comprising microalgal extracellular vesicles (MEVs) formulated for intranasal delivery are provided, whereby upon intranasal administration, the MEVs are transported by a specific route, to specific regions in the brain via the olfactory nerve after intranasal administration, and to interconnected brain regions through the lateral olfactory tract (LOT). The MEVs are transported via neuronal axonal transport. The MEVs have the ability to cross synapses including: (i) synapses between olfactory sensory neurons (OSNs) and mitral / tufted neurons; (ii) synapses between mitral / tufted neurons and local neurons in multiple brain regions colonized by the lateral olfactory tract (LOT); and (iii) synapses between neurons in brain regions colonized by the LOT and neurons from the frontal cortex, hippocampus, thalamus, and hypothalamus. The compositions contain extracellular vesicles (MEVs) from microalgae loaded with bioactive cargo for the treatment, detection, diagnosis, or monitoring of diseases, disorders, or conditions of or involving the brain, particularly neuronal delivery of the cargo. The compositions and methods have multiple applications as therapeutic and diagnostic agents for the treatment, diagnosis, and monitoring of diseases, disorders, or conditions of or involving the brain. The compositions can be used in methods and uses for the treatment of cancers involving the brain, and can be used, for example, to deliver therapeutic agents for psychiatric diseases, disorders, conditions, and to deliver therapeutic agents for neurodegenerative diseases, disorders, and conditions.

The invention relates to the technical field of intelligent aquaculture or precise aquaculture, in particular to a hippocampus health state intelligent identification method and a hierarchical breeding control system, and the method comprises the steps: collecting time sequence behavior data and breeding environment state data of hippocampus individuals; quantizing the time sequence behavior data to generate behavior characteristics; quantifying the breeding environment state data to generate environment characteristics; generating a dynamic health index in combination with the behavior characteristics and the environment characteristics; generating a pathological risk index based on the dynamic health index; combining the dynamic health index and the pathological risk index to generate a comprehensive seed reservation value index; according to the comprehensive seed reservation value index and a preset grading threshold value, the grade of the hippocampus individuals is determined; generating a sorting control instruction according to the grade; according to the method, intelligent decision making from pure preferential selection to preferential selection and risk avoiding is realized, and the screening efficiency of excellent germplasm is remarkably improved.

The invention relates to the technical field of biology, in particular to a swelling hippocampus antioxidative peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The hippocampus antioxidative peptide is prepared by adopting an ultrahigh pressure pretreatment and enzymolysis technology, the adopted extraction process is simple in route, and the time and the production cost are effectively saved; an animal model is used for proving the antioxidation effect of the hippocampus erectus antioxidative peptide and the effect of improving male reproductive disorder and testis injury; and on the basis, a novel peptide fragment with high activity, no toxicity and no sensitization is obtained.

The invention provides a memory enhancement system and method based on a closed-loop regulation brain-computer interface, and relates to the technical field of medical equipment, and the system comprises a multi-channel neural activity detection unit which is used for collecting the field potential waveforms of a plurality of brain regions, related to memory cognition, of the brain of a target object; the electroencephalogram signal analysis unit is used for sending a corresponding control signal to the electrical stimulation output unit under the condition that the field potential waveform of any target brain region meets a preset triggering condition; and the electrical stimulation output unit is used for applying electrical stimulation to the target brain area under the condition of receiving the control signal sent by the electroencephalogram signal analysis unit. According to the memory enhancement system and method based on the closed-loop regulation and control brain-computer interface provided by the invention, by synchronously implanting the microelectrodes of the hippocampus multi-subregion and the temporal lobe cortex of the brain in a cross-scale manner, the waveform information of the memory coding spike ripple is effectively identified, and the accurate stimulation output moment is fed back; and a customized closed-loop brain-computer interface system memory regulation strategy can be provided for different individuals.

The invention relates to the technical field of animal experiment devices, and discloses a spatial cognition enhancement device and method for three-dimensional rotational stimulation of a vestibular-hippocampus pathway, and the device comprises a rotational stimulation unit which is used for generating multi-axial angular acceleration stimulation; the animal adaptation unit is connected with the rotary stimulation unit and is used for fixing an experimental animal and blocking visual input; the control unit is in signal connection with the rotary stimulation unit and is used for adjusting stimulation parameters and collecting dynamic data; and the signal acquisition unit comprises a piezoresistive sensor and an analog-to-digital converter and is used for acquiring kinetic parameters of angular velocity and angular acceleration in real time. According to the space cognition enhancement device and method for three-dimensional rotation stimulation of the vestibular-hippocampus pathway, real three-dimensional space motion is simulated through multi-axial rotation, and targeted stimulation of the vestibular-hippocampus pathway is achieved in combination with adjustable rotating speed and visual shielding maintenance. The device is integrated with an acoustic intervention module and supports multi-mode intervention.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

A Bifidobacterium animalis subsp. lactis for reducing Abeta42 deposition and an application, a name of the Bifidobacterium animalis subsp. lactis is Bifidobacterium animalis subsp. lactis IOB-LO7, and classified as Bifidobacterium animalis subsp. lactis, the Bifidobacterium animalis subsp. lactis IOB-LO7 is preserved in the General Microbiology Center of the China General Microbiological Culture Collection Center (CGMCC) on Dec. 23, 2021, with the collection number of CGMCC No. 24185. By reducing the levels of Aβ42 in the cerebral cortex and hippocampus, clearing Aβ amyloid plaques, improving communication between neurons, reducing brain neuroinflammation, and protecting nerve cells, it helps to restore cognitive function and improve Alzheimer's disease. Additionally, it can also improve gut microbiota imbalance caused by Alzheimer's disease.

The invention discloses pediococcus acidilactici for improving offspring social behaviors of a parent and application thereof, and belongs to the technical field of microorganisms. According to the pediococcus acidilactici CCFM1344 provided by the invention, by intervening neurodysplasia caused by high-fat diet of a parent body, the improvement of hyperactivity and social behaviors of the offspring is specifically shown as follows: (1) hyperactivity disorder, induced by high-fat diet of the parent body, of the offspring in juvenile and adult periods is recovered; (2) restoring parent high-fat diet induced social contact disorders of offspring juveniles and adult periods; (3) reducing the gene expression of the small glial cell M1 type differentiation marker CD86 in the offspring hippocampus; and (4) reducing the gene expression of the macrophage activation marker F4 / 80 in the offspring hippocampus. Through the probiotic preparation containing the pediococcus acidilactici CCFM1344, a new thought and method can be provided for early intervention of the autism spectrum disorder.

The invention relates to the technical field of drying engineering, in particular to an intelligent temperature and humidity regulation and control system in the hot air series drying process of hippocampus, which comprises an internal moisture migration state real-time characterization module used for collecting the real-time total weight of hippocampus batches and calculating the internal moisture migration flux; the microwave hot air phase change switching control module is used for receiving the internal moisture migration flux, resolving the flux change rate of the internal moisture migration flux, constructing phase change switching conditions and stopping microwave output and starting the hot air drying potential dynamic balance regulation and control module when the phase change switching conditions are met; the hot air drying potential dynamic balance regulation and control module is used for receiving the internal moisture migration flux, calculating a dynamic target external evaporation rate set point and resolving a controller output signal used for regulating hot air parameters; the problems that the contradiction between the drying efficiency and the quality of the hippocampus is solved, and the internal state of materials cannot be sensed through traditional control are solved.

The invention discloses a universal identification primer, kit and method for hippocampus. The universal identification primer for the hippocampus comprises HipF: 5 '-GGCCATACCCAAAAATG-3' and HipR: 5 '-TTTAGCTTATTAAAGTGTCTGTTTTGCA-3'. The universal identification primer for the hippocampus can be used for identifying 10 types of hippocampus, and the amplification efficiency of the universal identification primer is higher than that of the identification primer in the prior art, so that conditions are provided for developing an efficient, accurate and practical hippocampus variety identification technical method and effectively popularizing and improving the hippocampus variety identification technical capability.

The invention relates to application of bifidobacterium animalis subsp. Lactis BLa80 in preparation of a preparation for relieving depression or anxiety. The bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.22547, and the strain of the bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC No.22547. The invention develops a brand new application of the bifidobacterium animalis subsp. Lactis BLa80 strain, namely, the bifidobacterium animalis subsp. Lactis BLa80 strain is used for relieving depression or anxiety symptoms, specifically, the bifidobacterium animalis subsp. Lactis BLa80 strain can stimulate RIN14B cells to secrete 5-HT, can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety, can relieve hyperfunction of hypothalamic-pituitary-adrenal axis (HPA axis), and can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety. The inflammatory response of mice with depression and anxiety is relieved, the expression level of brain-derived neurotrophic factors in hippocampus of the mice with depression and anxiety is improved, the abundance of intestinal beneficial flora of the mice with depression and anxiety is improved, and the diversity of intestinal flora is increased.

The invention discloses a preparation method of hippocampus oil, which comprises the following steps: 1) adding dried hippocampus powder into a dichloromethane-methanol mixed solution, uniformly stirring, and extracting for 24 hours; 2) filtering the leach liquor, adding water, fully and uniformly mixing, standing for 12 hours, and collecting a lower layer organic phase; 3, the organic phase is subjected to rotary evaporation drying.The invention further discloses application of the hippocampus oil in preparation of uric acid lowering products.The hippocampus oil is rich in omega-3 polyunsaturated fatty acid (EPA and DHA), the activity of xanthine oxidase is moderately reduced, release of inflammatory factors is inhibited, and the comprehensive effect of inhibiting generation and relieving inflammation is achieved.

The invention belongs to the technical field of food nutrition and health, and particularly discloses protein powder for assisting in improving Alzheimer's disease and a preparation method of the protein powder according to the concept of dietary therapy in China, and the protein powder is prepared from the following components in percentage by weight: 35-45% of egg white protein peptide powder and 55-65% of core function compound powder. According to the invention, egg white protein peptide is used as a high-quality matrix, and nine specific medicinal materials including hippocampus, egg yolk phospholipid, egg membrane peptide, walnut, fructus alpiniae oxyphyllae, gastrodia elata, mulberry, sargassum fusiforme, wolfberry, ginkgo leaf, fructus evodiae and dandelion are cooperatively compatible; aiming at seven core pathological links of Alzheimer's disease, such as A beta deposition, Tauopathy, neuroinflammation, oxidative stress, cholinergic deficiency, neurodystrophy and cerebral circulation disorder, a multi-target synergistic effect network is constructed, comprehensive neuroprotection is realized, and tests prove that the space learning and memory ability and the autonomous activity ability can be effectively improved.

The invention discloses a fault diagnosis method based on multi-source data fusion and a deep optimization network, and belongs to the technical field of wind turbine generator bearing fault diagnosis, and the method comprises the steps: obtaining multi-source sensor data of a wind turbine generator under different working conditions, and carrying out the preprocessing of the collected multi-source sensor data; designing a multi-source data feature fusion algorithm based on correlation variance contribution, fusing the preprocessed multi-source sensor data, and extracting a fuzzy entropy value from the fused multi-source sensor data as a feature vector input into the intelligent fault diagnosis model; constructing an intelligent fault diagnosis model DBE based on the optimized deep belief network, and training the DBE by adopting a greedy learning method and a hippocampus optimization algorithm; and performing fault diagnosis based on the trained DBE. According to the method, the problems of signal abnormal value and data missing and fault diagnosis reliability under the influence of variable working conditions and external noise interference of the wind turbine generator are solved, and the fault diagnosis accuracy of the wind turbine generator is improved.

This invention belongs to the field of pharmaceutical technology, specifically relating to a quinazoline-azaindole compound, its preparation method, and its application in treating Alzheimer's disease. The quinazoline-azaindole compound of this invention regulates NF-κB by inhibiting DYRK1A. k B. A series of signaling pathways, including PI3k-Akt, achieve anti-neuroinflammatory effects; quinazoline-azaindole compounds can reduce the expression of inflammatory factor-related genes in an LPS-induced BV2 microglial inflammation model, thereby reducing the levels of inflammatory factors in the hippocampus and cortex, alleviating neuronal pathological damage caused by neuroinflammation, and improving cognitive impairment caused by neuroinflammation; in summary, quinazoline compounds inhibit DYRK1A and downregulate NF-κB signaling pathways. k It can reduce the expression and release of inflammatory factors, improve brain tissue pathology, and alleviate cognitive impairment through signaling pathways such as B, and has significant clinical application value.

The invention discloses a multi-modal feature fusion prediction method and system for early screening of Alzheimer's disease, and belongs to the technical field of brain disease prediction. The method comprises the following steps: acquiring multi-dimensional data containing cognitive test scores, brain image scanning results and biomarker concentration levels from a patient record database, and performing standardization processing to obtain a multi-dimensional data set in a unified format; key feature vectors are extracted through a dimensionality reduction analysis method to capture the covariant relation between cognitive test scores and brain image changes; when the reduction range of the cognitive test score exceeds a preset threshold value and the brain image displays an atrophy sign, a classification model is constructed through an integrated learning method to preliminarily classify abnormal signals; and fusing the biomarker concentration level to obtain an abnormal signal vector. According to the method, the accuracy and efficiency of early screening of brain diseases such as Alzheimer's disease are remarkably improved through accurate evaluation of key parts of the human brain, such as hippocampus.

The invention provides a traditional Chinese medicine preparation for treating postpartum depression and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Chinese rose flowers, hypericum perforatum, caulis polygoni multiflori, tortoise shells, radix hedysari, aleppo avens, perilla stems, officinal magnolia flowers, fructus podophylli, loofah sponge, fructus choerospondiatis, entada phaseoloides, rhizoma polygonati and other traditional Chinese medicine raw materials. The traditional Chinese medicine preparation integrates the methods of soothing liver-qi stagnation, nourishing blood for tranquilization, tonifying qi and nourishing yin, promoting blood circulation to remove meridian obstruction and promoting qi circulation to relieve middle energizer, gives consideration to both symptoms and root causes, not only relieves the symptom of postpartum liver depression, but also tonifies the root cause of deficiency of qi and blood, so that liver qi is smooth, qi and blood are full and mind is nourished, and the traditional Chinese medicine preparation has the effect of preventing and treating postpartum depression. The traditional Chinese medicine preparation provided by the invention can improve nervous system functions by influencing expression of hippocampus 5-HT and DA so as to realize the effect of regulating depression-like behaviors; the traditional Chinese medicine composition has a remarkable curative effect on postpartum depression and has a remarkable effect of improving and relieving depressive clinical symptoms of patients.

This invention discloses a medical image segmentation method based on inverse residual attention and multi-scale context. The method inputs the medical image to be segmented into an improved RAS-UNet segmentation network model. This model introduces an inverse residual attention module at the bottleneck feature of the deepest layer of the encoder, which suppresses background through an inverse weighting mechanism and enhances attention to blurred boundaries and weak response regions. Simultaneously, a hollow spatial pyramid pooling module is introduced into the decoding path, utilizing a parallel multi-branch structure to fuse multi-scale contextual information to adapt to lesions or anatomical structures of different sizes. Skip connections between the encoder and decoder achieve efficient fusion of detailed and semantic features. This invention can significantly improve the accuracy and boundary accuracy of segmenting medical targets such as polyps, breast tumors, and the hippocampus, providing a reliable tool for clinical auxiliary diagnosis.

The invention provides a senile dementia early diagnosis method based on hippocampus magnetic resonance imaging, which comprises the following steps that: according to a segmented image, a contour extraction algorithm is adopted to obtain multi-layer two-dimensional contour data to obtain a contour sequence, and the contour extraction algorithm carries out gradient analysis and threshold filtering on geometric features of a hippocampus, and captures boundary details; the contour sequence is subjected to space alignment processing, an alignment contour set is obtained, displacement deviation between different layers is eliminated through a transformation correction method in the space alignment processing, and the alignment contour set is generated; calculating volume and morphological indexes according to the preliminary three-dimensional model, and determining the atrophy degree; and comparing the refined three-dimensional structure with a preset reference model to generate difference mapping, judging the diagnosis precision, and adopting a geometric feature deviation measurement method to evaluate the structural difference in comparison to generate the difference mapping. According to the method, the fidelity and diagnosis precision of three-dimensional reconstruction of the hippocampus are remarkably improved, and reliable technical support is provided for early diagnosis of neurodegenerative diseases.

The present application relates to the preparation and application field of biological peptide, and more particularly to a hippocampus abdominalis peptide and its application in preparation of products for reducing uric acid and resisting gout. The amino acid sequence is shown as SEQ ID NO. 1, and the present application confirms the uric acid reducing effect through in vitro xanthine oxidase (XOD) and adenosine deaminase (ADA) inhibition experiments and cell experiments; on this basis, the uric acid reducing and gout resisting activity of the peptide sequence is further verified by means of a high uric acid animal model. This achievement provides a solid theoretical support for high-value development and utilization of hippocampus abdominalis, and research and development of products for reducing uric acid and resisting gout.