1712results about "Head electrodes" patented technology

A device, including an electrode array carrier, that carries one or more electrode arrays, and a therapeutic substance such as for example an anti-inflammatory, wherein the therapeutic substance is located in at least one cavity of the carrier, the cavity having at least one of a non-uniform depth or a non-uniform width with respect to location in a direction of the depth that has an effective impact on a delivery of the therapeutic substance to a human.

A method for treating nerves in a nasal cavity starts with identifying a patient having a condition occurring outside the nasal cavity. The method then involves activating a console attached to a radiofrequency stylus, advancing a distal tip of the radiofrequency stylus into a nostril of the patient, contacting nasal mucosa lining the nasal cavity with a treatment surface of the distal tip, and delivering radiofrequency energy from one set of bipolar electrodes on the treatment surface of the distal tip to a second set of bipolar electrodes on the treatment surface, to treat at least one nerve underlying the nasal mucosa. Treating the nerve (or nerves) involves modulating activity of the nerve to ameliorate the condition occurring outside the nasal cavity.

The invention discloses a brain deep nerve stimulation method and system based on adaptive adjustment, and relates to the technical field of brain deep nerve regulation, and the method comprises the steps: collecting a local field potential signal of a brain deep target region of a target patient, and extracting a beta frequency band power spectrum density and a gamma frequency band phase synchronization index as neural activity characteristic parameters; determining an individual baseline value and a preset threshold value based on historical data, and outputting a stimulation adjustment trigger signal when the beta frequency band power spectral density exceeds the individual baseline value and the gamma frequency band phase synchronization index is lower than the preset threshold value; in response to the trigger signal, calculating an optimal stimulation parameter combination through a gradient descent optimization algorithm and executing nerve regulation; and monitoring the signal change after regulation and control, calculating a relative change rate and updating a threshold value. Through a two-parameter joint judgment mechanism and a threshold updating strategy, individualized adaptive adjustment of stimulation parameters is realized, and the stimulation accuracy and the treatment effect are improved.

The invention provides an intracranial neuron electrical stimulation system for treating epilepsy and other brain diseases involving epileptic seizure, which can immediately apply intracranial neuron electrical stimulation to the interseizure epilepsy activity in a personalized manner after detecting the interseizure epilepsy pattern each time. And the stimulation is activated by intracranial electroencephalogram (EEG) detection. The intracranial stimulation for epileptic activities in the epileptic seizure period continuously acts along with time, the forming process of an epileptic network can be blocked, the neuronal super-synchronization risk is reduced, and therefore the control effect on epileptic seizure is improved. The invention also includes the use of nerve adjustment biomarkers, thereby dynamically optimizing the detectability and providing more accurate overall assessment for the patient's treatment progress. Finally, according to the scheme, by detecting the intracranial EEG mode and the high-risk state mode (such as the epileptic state and the sudden accidental death risk in epilepsy) in the attack period, an instant alarm is given to the patient / nursing personnel, and it is ensured that safe treatment measures are taken for the patient in time.

The invention discloses a closed-loop deep brain regulation and control system for epilepsy treatment, and the system comprises an electroencephalogram signal collection module which collects neural electrophysiological signals in real time by implanting a recording electrode in a cerebral cortex or hippocampal brain area; the electroencephalogram signal real-time analysis module is used for outputting the epileptic seizure period prediction probability xi through a seven-layer full-connection neural network based on the 33-dimensional feature vector so as to realize epileptic seizure early warning; when the zeta is greater than or equal to a threshold value, the electrical stimulation regulation and control module is used for triggering electrical stimulation, filtering out a frequency band required to be regulated and controlled according to filtering, calculating and predicting electrical stimulation intensity and then correcting and outputting pulse stimulation, so that personalized electrical stimulation regulation and control are carried out on a specific frequency band, and detection is continuously carried out until the frequency band becomes normal; and the medicine intervention module is used for triggering a micro-injection pump to carry out medicine infusion through a pulse signal. According to the system, epilepsy treatment is improved from empirical parameter adjustment to accurate regulation and control based on real-time nerve physiological signals, and a safer and more effective treatment choice is provided for a drug-refractory epilepsy patient.

Obstructive sleep apnea from blockage of the upper airway can result in significant health issues. Described herein is an intelligent personalized closed loop neuromodulation system and methods to prevent backwards movement of the genioglossus muscle through stimulation of certain branches of the hypoglossal nerve and muscle motor points, by using muscle feedback from electromyogram sensors to provide optimal stimulus. Alternative embodiments to treat neuropathic pain and urinary dysfunction are enclosed.

An implantable medical device to restore brain-controlled movement and sensation after neural injury. The device comprises a brain-computer interface capable of acquiring electrocorticogram (ECoG) signals recorded directly from the surface of the brain and uses the signals to enable direct control of paralyzed muscles, limbs or extremities while simultaneously receiving signals from external sensors and converting them into electrical stimulation patterns for the brain's sensory areas.

Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.

An auditory neural interface device for sound perception by an individual that may be used as a hearing aid. The auditory neural interface device includes a receiver configured to receive sound signals, a processor operably connected to the receiver and configured to encode a received sound signal as a multi-channel neurostimulation signal, and a neurostimulation device operably connected to the processor and configured to apply the multi-channel neurostimulation signal to a neurostimulation electrode of the individual. The neurostimulation signal is configured to directly stimulate afferent sensory neurons of the central nervous system of the individual and thereby to elicit, for each channel of the neurostimulation signal, one or more non-auditory, preferably somatosensory, perceptions in a cortex area of the individual. Each channel of the neurostimulation signal is associated with a different non-auditory perception.

The present invention relates to a reduced graphene oxide structure for stimulation and / or recording of the central and / or peripheral nervous system comprising a stack of layered, reduced graphene oxide flakes, wherein the reduced graphene oxide structure is electrochemically activated.

The invention belongs to the technical field of medical apparatus and instruments, and particularly provides an eye-brain organ complex visual restoration system based on cooperative training, comprising: an eye-brain organ complex construction module for constructing a functional eye-brain organ complex; the signal processing module is used for collecting and processing an initial nerve spike signal generated by the brain organ; the stimulation signal generation module is used for generating an electrical stimulation signal for simulating the response of the photoreceptor through an adaptive modulation algorithm; the signal decoding and mapping module is used for stimulating a brain organ to generate a new nerve spike signal based on the electrical stimulation signal and decoding the new nerve spike signal into an external equipment control instruction; and the closed-loop feedback control module is used for performing closed-loop feedback control and optimization on the eye and brain organ complex visual restoration system based on cooperative training. According to the invention, the visual information in the biological signal can be correctly identified and utilized.

An electrode lead comprising an elongate lead body having a proximal end, a distal end and a plurality of electrical conductors, a biologically compatible, elastic, electrically insulative nerve cuff body that is associated with the distal end of the lead body, is configured to be circumferentially disposed around a nerve, has a pre-set furled state that defines an inner lumen and is movable to an unfurled state, a plurality of electrically conductive contacts carried by the nerve cuff body and electrically associated with the electrical conductors, and an inflatable nerve cuff straightener associated with the nerve cuff body and configured to at least substantially straighten the nerve cuff body when in a fully inflated state.

The invention relates to the field of damaged vision recovery of artificial retinas, and particularly discloses a preparation method of a neuromorphic visual interface for recovering the pattern recognition capability of a blind animal. The interface is composed of a photo-thermal assembly, a photoelectric assembly and an electrode array. The photo-thermal assembly is dispersed in a continuous medium, can rapidly and transversely transfer a thermal signal, and is used for repairing the rapid extraction process of an animal visual pathway on a graphic contour; the electrode arrays are located on the upper surface and the lower surface of the photoelectric assembly, can vertically transmit electric signals in a delayed mode and correspond to the follow-up pattern detail machining process of a visual path. The interface also reproduces a central-peripheral activation-inhibition effect formed by retinal horizontal / bipolar cell transverse / longitudinal signal transmission, and realizes multi-channel signal connection with a visual center. The technology is mature, processing is simple, an artificial system which is highly matched with animal optic nerve signals and functions is developed, the artificial system is different from existing light magical vision, and recovery of the pattern recognition function is achieved.

An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

A neurostimulation system may include an implantable neurostimulator. An implantable neurostimulator may include a first sensor configured to sense internal data relating to a symptom of a neurological movement disorder of a patient. An implantable neurostimulator may include an internal stimulator configured to provide an internal stimulation output to an internal target area of a patient. An implantable neurostimulator may include a first wireless communication device configured to communicate internal data with a network. A neurostimulation system may include a wearable neurostimulator. A wearable neurostimulator may include a second sensor configured to sense external data of a patient. A wearable neurostimulator may include an external stimulator configured to provide an external stimulation output to an external target area of a patient. A wearable neurostimulator may include a second wireless communication device configured to communicate external data with a network and receive internal data from the network.

The invention provides an implantable retina photon nerve repairing method and device, and relates to the field of implantable nerve regulation and control. The method comprises the following steps: acquiring a target image in a current visual field of a user based on external wearing equipment; adopting an edge detection algorithm to extract visual key features in the target image; based on the visual key features, time control pulse coding is adopted to generate a target stimulation pattern; performing neural feedback acquisition based on the target stimulation pattern, and acquiring neural electrical activity information through a feedback electrode preset on an implanted chip; based on the neural electrical activity information, the target stimulation pattern is dynamically adjusted through an adaptive optimization algorithm to perform optic nerve repair. The problem that a traditional implantable retina photon nerve repairing method is poor in retina photon nerve repairing effect is solved.

An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

Mandibular repositioning devices have a mandibular piece having a first teeth covering and having a housing proximate each of a left molar portion and a right molar portion, a protrusive flange extending cranially from each housing, and a maxillary piece having a second teeth covering and having a housing proximate each of a left molar portion and a right molar portion. Each housing encloses a power source electrically connected an on-board circuit board and the housings of the maxillary piece further have the power source electrically connected to a motor operatively connected to a drive for anterior and posterior movements of the mandibular piece. The maxillary piece sits on the mandibular piece with the driver operatively engaged with the protrusive flange. The protrusive flange has a concavely-shaped anterior surface mated to a convexly-shaped head of the driver shaped to match the concavely-shaped anterior surface of the protrusive flange.

Methods of making soft probes, such as soft neural probes, are provided. The fabrication method entails fabricating a soft probe, such as a free-standing soft neural probe, on a fabrication substrate, and releasing the fabricated neural probe from the substrate without damage. The methods may involve depositing alternating insulating flexible polymer layers, such as elastomers, and conductive or semiconductive material layers.

The invention discloses an olfactory reconstruction electrical stimulation regulation and control system for a nerve prosthesis, and the system comprises a sensor, an electrode array, a control unit, a signal processing module, a wireless transmission module, an electrode driving module, and a feedback collection module. The olfactory bulb, the olfactory epithelium or the olfactory cortex are electrically stimulated through the array electrode, and the smell sensing process is simulated. According to the invention, olfaction signal transmission is reconstructed by accurately regulating and controlling electrical stimulation parameters, and a patient with olfaction loss is helped to recover perception of surrounding environment smell. The system has the advantages of high precision, controllability, personalized adaptation and the like, and an innovative technical scheme is provided for perception recovery of olfactory deficiency patients.

The embodiment of the invention discloses a brain deep part electrical stimulation operation planning system and method based on a human brain network and a Lead-DBS technology, and the system and method are applied to operation planning of neuropsychiatric diseases. The data preprocessing module is used for denoising, correcting and standardizing the patient data to generate preprocessed data; the brain network model construction module is used for determining a functional connection matrix and a structural connection matrix based on the preprocessed data so as to construct an individualized brain network model; the electrode positioning module is used for generating an implantation target spot of a DBS electrode based on an individualized brain network model; the stimulation parameter optimization module optimizes stimulation parameters of the DBS based on the individualized brain network model and the electrophysiological data; the postoperative evaluation module compares the postoperative image with the preoperative plan to verify the actual implantation position and stimulation effect of the DBS electrode; the dynamic adjustment module is used for dynamically adjusting stimulation parameters.

A method of facilitating a skill learning process or improving performance of a task, comprising: determining a brainwave pattern reflecting neuronal activity of a skilled subject while engaged in a respective skill or task; processing the determined brainwave pattern with at least one automated processor; and subjecting a subject training in the respective skill or task to brain entrainment by a stimulus selected from the group consisting of one or more of a sensory excitation, a peripheral excitation, a transcranial excitation, and a deep brain stimulation, dependent on the processed temporal pattern extracted from brainwaves reflecting neuronal activity of the skilled subject.

The embodiment of the invention discloses program control equipment and a medical system. The program control equipment is in communication connection with a stimulator implanted into a target object, and comprises a display interface and a processor, the display interface comprises a display unit for at least displaying a postoperative brain model of a target object, an operation unit for an operation object to execute parameter selection, and a program control unit for delivering a stimulation instruction to the stimulator; wherein the processor is configured to select and generate a target electric field model displayed on the postoperative brain model displayed on the display unit in an overlapping manner based on target stimulation parameters of an operation object on the operation unit, so that the operation object adjusts the target stimulation parameters on the operation unit based on the target electric field model displayed on the display unit; and under the condition that the operation object triggers the program control unit, the target stimulation parameter is sent to the stimulator in a soft output mode. According to the technical scheme, the accuracy of the adopted stimulation parameters can be improved.

Occipital lobe stimulation device comprising normal looking glasses having a frame portion with side portions and lens portions, provided together with a battery-powered plurality of Light-Emitting Diodes (LEDs) fixed around an anterior periphery of the frame portion for emitting photons of light to reflect off of an object in the outside world, and a plurality of photoreceptors dispersed across and retained in the lens portions, the photoreceptors being connected via wires to corresponding inverters in the side portions which are also wire connected to output devices on a strap an enabling connection to corresponding input devices surgically implanted and connected to the user's occipital lobes, for transmitting image information relating to the object to the user's occipital lobes to enable the user's brain to make use of the information.

The invention relates to the field of medical instruments, in particular to a minimally invasive implantation device, a computer program product and a calibration method.A propelling assembly is arranged in a shell of the implantation device, one end of a clamp is connected to the propelling assembly, and the other end of the clamp extends out of the shell to be used for clamping an implant; the propelling assembly is used for driving the clamp to extend or retract relative to the shell; the force sensor is mounted on the propelling assembly, is coupled with the clamp and is used for detecting the implantation force of the clamp; the controller is electrically connected with the propelling assembly and the force sensor. The controller can control the clamp to retreat when the implanting force detected by the force sensor is larger than a preset value. In the implanting process of the artificial cochlea electrode, when the implanting force is too large, the clamp of the implanting device drives the implanting piece to automatically return, the inner ear structure of a patient is prevented from being damaged, the risk that the inner ear is damaged due to the fact that hand control is not timely in the operation process is effectively avoided, and the operation efficiency and safety are improved.

A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.

A method of transplanting a desired emotional state from a donor to a recipient, comprising determining an emotional state of the donor, recording neural correlates of the emotional state of the donor who is in the desired emotional state; analyzing neural correlates of the emotional state of the donor to decode at least one of a temporal and a spatial pattern corresponding to the desirable emotional state; converting said at least one of a temporal and a spatial pattern corresponding to the desirable emotional state into a neurostimulation pattern; storing the neurostimulation pattern in the nonvolatile memory; retrieving the neurostimulation pattern from the nonvolatile memory; stimulating the recipients brain with at least one stimulus modulated with the neurostimulation pattern to induce the desired emotional state in the recipient.

Mandibular repositioning devices have a maxillary piece and a mandibular piece each of which is configured to cover a user's teeth. The maxillary piece has a right back teeth portion and / or a left back teeth portion and a driver flange protruding laterally outward from either or both thereof. Each driver flange has a driving side with a convex surface. The mandibular piece has a protrusive flange extending cranially therefrom and positioned with an engaging side thereof engaged against the driving side of the driver flange. The engaging side of the protrusive flange has a concave surface which mates with the convex surface of the driver flange when the mouth is closed and is in continuous contact thereagainst as a user moves their jaw downward, thereby providing gradual arcuate incremental forward mandibular movement as the concave surface of the protrusive flange smoothly glides against the convex surface of the driver flange.

A method and system for protecting electrode arrays while implanted on a brain including a flexible electrode array including non-penetrating cortical surface microelectrodes, a ceramic layer covering the electrode array and a polymer layer adjacent the ceramic layer, wherein the ceramic layer and the polymer layer hermetically seal the electrode array. The ceramic layer can be configured to exhibit sufficient flexibility to allow the electrode array to be implanted using minimally invasive surgical techniques, while still hermetically sealing the electrode array from a biological environment.