2341results about "Head electrodes" patented technology

An in vitro training method includes scanning a user's oral cavity to create a first oral cavity model. An articulator body is selected according to the first oral cavity model, and plural first customized electrode sheets are formed and assembled onto the articulator body to obtain an in vitro training device. The user bites the in vitro training device during a non-sleep period and uses the plural first customized electrode sheets to proceed with electrical stimulation on a top surface and two sides of a tongue of the user, thereby training a muscular endurance of infrahyoid muscles of the user for a training period. The user's oral cavity is scanned again to create a second oral cavity model. The first oral cavity model is compared with the second oral cavity model to timely renew the customized electrode sheets when the image over rate is lower than 80%.

Embodiments described herein relate to systems, devices, and methods for monitoring brain activity and delivering electrical brain stimulation to a patient. In some embodiments, a system can deliver responsive electrical stimulation in a closed-loop manner and can offer real-time or near real-time monitoring of induced neurophysiological effects. After detecting a targeted brain pattern (i.e., an epileptic seizure), the system may deliver high-intensity ultra-short electrical stimulation impulses non-invasively or minimal-invasively to diminish or stop the neural oscillations underlying the epileptic seizure. The stimuli are delivered in time and space, relative to the emerging seizure rhythm patterns, such that they diminish or terminate the seizure. The system may include an implantable device including one or more electrodes electrically coupled to one or more processors. The processor(s) may be operatively coupled to a memory, one or more communication modules, and may optionally be coupled to a battery and one or more additional sensor(s).

Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.

A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

An electrical stimulation lead includes electrodes disposed on a cuff body and arranged into at least a first row, a second row, and a third row, where the second row is disposed between the first and third rows, and each electrode in the first row is electrically coupled to a corresponding electrode in the third row. In another electrical stimulation lead the electrodes are arranged so that the first and third rows each include multiple electrodes and the second row, between the first and third rows, includes at least one electrode with each electrode in the second row at least twice as long as each of the electrodes of the first and third rows. In another electrical stimulation lead the electrodes are arranged so that each electrode in the first and third rows is at least twice as long as each of the electrodes of the second row.

A device, including an electrode array carrier, that carries one or more electrode arrays, and a therapeutic substance such as for example an anti-inflammatory, wherein the therapeutic substance is located in at least one cavity of the carrier, the cavity having at least one of a non-uniform depth or a non-uniform width with respect to location in a direction of the depth that has an effective impact on a delivery of the therapeutic substance to a human.

A method for treating nerves in a nasal cavity starts with identifying a patient having a condition occurring outside the nasal cavity. The method then involves activating a console attached to a radiofrequency stylus, advancing a distal tip of the radiofrequency stylus into a nostril of the patient, contacting nasal mucosa lining the nasal cavity with a treatment surface of the distal tip, and delivering radiofrequency energy from one set of bipolar electrodes on the treatment surface of the distal tip to a second set of bipolar electrodes on the treatment surface, to treat at least one nerve underlying the nasal mucosa. Treating the nerve (or nerves) involves modulating activity of the nerve to ameliorate the condition occurring outside the nasal cavity.

A wireless implantable neuromuscular stimulator includes an antenna for producing an induced current in response to being disposed in an electromagnetic field. The antenna includes a substrate having an upper surface and a lower surface. An upper coil including a plurality of coil turns is disposed on the upper surface of the substrate. A lower coil including a plurality of coil turns is disposed on the lower surface of the substrate. The upper and lower coils are electrically connected to each other in parallel. The parallel connection can be facilitated by a plurality of connectors that extend through the substrate and electrically connect the upper coil to the lower coil. In one example configuration, connectors connect each coil turn of the upper coil to a corresponding turn of the lower coil.

The invention discloses a brain deep nerve stimulation method and system based on adaptive adjustment, and relates to the technical field of brain deep nerve regulation, and the method comprises the steps: collecting a local field potential signal of a brain deep target region of a target patient, and extracting a beta frequency band power spectrum density and a gamma frequency band phase synchronization index as neural activity characteristic parameters; determining an individual baseline value and a preset threshold value based on historical data, and outputting a stimulation adjustment trigger signal when the beta frequency band power spectral density exceeds the individual baseline value and the gamma frequency band phase synchronization index is lower than the preset threshold value; in response to the trigger signal, calculating an optimal stimulation parameter combination through a gradient descent optimization algorithm and executing nerve regulation; and monitoring the signal change after regulation and control, calculating a relative change rate and updating a threshold value. Through a two-parameter joint judgment mechanism and a threshold updating strategy, individualized adaptive adjustment of stimulation parameters is realized, and the stimulation accuracy and the treatment effect are improved.

The invention provides an intracranial neuron electrical stimulation system for treating epilepsy and other brain diseases involving epileptic seizure, which can immediately apply intracranial neuron electrical stimulation to the interseizure epilepsy activity in a personalized manner after detecting the interseizure epilepsy pattern each time. And the stimulation is activated by intracranial electroencephalogram (EEG) detection. The intracranial stimulation for epileptic activities in the epileptic seizure period continuously acts along with time, the forming process of an epileptic network can be blocked, the neuronal super-synchronization risk is reduced, and therefore the control effect on epileptic seizure is improved. The invention also includes the use of nerve adjustment biomarkers, thereby dynamically optimizing the detectability and providing more accurate overall assessment for the patient's treatment progress. Finally, according to the scheme, by detecting the intracranial EEG mode and the high-risk state mode (such as the epileptic state and the sudden accidental death risk in epilepsy) in the attack period, an instant alarm is given to the patient / nursing personnel, and it is ensured that safe treatment measures are taken for the patient in time.

The invention discloses a closed-loop deep brain regulation and control system for epilepsy treatment, and the system comprises an electroencephalogram signal collection module which collects neural electrophysiological signals in real time by implanting a recording electrode in a cerebral cortex or hippocampal brain area; the electroencephalogram signal real-time analysis module is used for outputting the epileptic seizure period prediction probability xi through a seven-layer full-connection neural network based on the 33-dimensional feature vector so as to realize epileptic seizure early warning; when the zeta is greater than or equal to a threshold value, the electrical stimulation regulation and control module is used for triggering electrical stimulation, filtering out a frequency band required to be regulated and controlled according to filtering, calculating and predicting electrical stimulation intensity and then correcting and outputting pulse stimulation, so that personalized electrical stimulation regulation and control are carried out on a specific frequency band, and detection is continuously carried out until the frequency band becomes normal; and the medicine intervention module is used for triggering a micro-injection pump to carry out medicine infusion through a pulse signal. According to the system, epilepsy treatment is improved from empirical parameter adjustment to accurate regulation and control based on real-time nerve physiological signals, and a safer and more effective treatment choice is provided for a drug-refractory epilepsy patient.

Devices, systems, software, and methods are provided for treating sleep dysfunction in a subject using nighttime deep brain stimulation. Deep brain stimulation is performed with a neural recording device that records brain electrical signal data while the subject is sleeping. Machine learning computational models are used to detect and classify patterns of neural activity associated with different sleep features or sleep stages. An adaptive deep brain stimulation algorithm is provided that modulates stimulation parameters using intracranially classified sleep features or sleep stages to target sleep dysfunction. Methods and systems are also provided for performing closed-loop therapy with a deep brain stimulator that records brain electrical signals from subcortical or cortical neural activity associated with selected sleep features or stages and automatically adjusts deep brain stimulator settings and / or delivers deep brain electrical stimulation when pre-specified patterns of neural activity associated with a selected sleep feature or sleep stage are detected.

The invention provides a primitive-based brain-like visual prosthesis system, a partitioned electrical stimulation method and a partitioned electrical stimulation device, and relates to the technical field of visual prostheses. A primitive-based brain-like visual sensor acquires a space-time difference image and a color intensity image, performs primitive extraction to obtain multiple pieces of primitive information in a multi-bit form; encoding by adopting different encoding modes through a pulse encoder to obtain a plurality of pieces of primitive information in a single-bit form; and the processor controls the implantable electrode arrays in different areas to generate electrical stimulation signals based on the primitive information in a multi-bit form or a single-bit form, generates regulation and control signals based on the fed-back electroencephalogram signals, and adjusts attribute parameters of the brain-like vision sensor based on the regulation and control signals. Based on the characteristics of low bandwidth, high robustness and pulse coding of the brain-like vision sensor, the brain-like vision prosthesis system can efficiently perceive the external environment and perform partitioned electrical stimulation based on primitive processing, so that the visual experience of a user is improved.

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

A neurostimulation system may include an implantable neurostimulator. An implantable neurostimulator may include a first sensor configured to sense internal data relating to a symptom of a neurological movement disorder of a patient. An implantable neurostimulator may include an internal stimulator configured to provide an internal stimulation output to an internal target area of a patient. An implantable neurostimulator may include a first wireless communication device configured to communicate internal data with a network. A neurostimulation system may include a wearable neurostimulator. A wearable neurostimulator may include a second sensor configured to sense external data of a patient. A wearable neurostimulator may include an external stimulator configured to provide an external stimulation output to an external target area of a patient. A wearable neurostimulator may include a second wireless communication device configured to communicate external data with a network and receive internal data from the network.

Obstructive sleep apnea from blockage of the upper airway can result in significant health issues. Described herein is an intelligent personalized closed loop neuromodulation system and methods to prevent backwards movement of the genioglossus muscle through stimulation of certain branches of the hypoglossal nerve and muscle motor points, by using muscle feedback from electromyogram sensors to provide optimal stimulus. Alternative embodiments to treat neuropathic pain and urinary dysfunction are enclosed.

Techniques for remote monitoring of a patient and corresponding medical device(s) are described. The remote monitoring comprises determining identification data and identifying implantable medical device (IMD) information, initiating an imaging device and determining an imaging program, receiving one or more frames of image data including image(s) of an implantation site, identifying an abnormality at the implantation site, triggering a supplemental image capture mode, receiving one or more supplemental images of the implantation site, and outputting the one or more supplemental images of the implantation site.

A system to configure a neurostimulation signal to a patient's body has a neurostimulator to create a base stimulation signal which has a series of first pulses. A computer processor within the neurostimulator deconstructs the first series of pulses into a first and second partial pulse series which have respective first and second partial electrical pulses where the first and second partial electrical pulses substantially summate to the base stimulation signal. A programmable signal generator provides a constant amplitude of combined stimulation pulses by applying the first and second partial pulses to a number of contacts of an electrode positionally located to stimulate a target tissue in the patient's body.

A system for automated programming of stimulation devices uses machine learning with multimodal medical imaging data to determine optimal patient-specific parameters. The system stores voxel-level intensity and functional imaging data from patients who previously underwent stimulation therapy. Similarity metrics calculated directly between the raw imaging data are used to cluster patients into phenotypic groups. Known therapeutic outcomes for each patient are linked to the associated stimulation parameters. For a new patient, biomarkers are extracted from their medical imaging data and used to identify phenotypically similar groups. The stimulation parameters with beneficial outcomes in those groups are analyzed to determine target recommended settings or discard suboptimal settings for the new patient. This data-driven approach leverages machine learning on multimodal medical imaging to automate patient-specific programming of stimulation therapy devices for optimal therapeutic benefit without requiring spatial normalization or atlas registration.

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

The invention discloses a stimulating electric field display method, device, system and equipment, a medium and a product. The method comprises the steps that in response to a model display operation, a target object and a brain tissue image model corresponding to the target object are determined, and the brain tissue image model comprises at least one deep brain stimulation electrode model; in response to the electrode configuration operation, determining electrode configuration information and stimulation parameter application information of each electrode model; and in response to an electric field display operation, determining program-controlled electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information, and displaying the program-controlled electric field information on the displayed brain tissue image model. Based on the technical scheme of the invention, the effect of quickly calculating and displaying the distribution condition of the program-controlled electric field simulated by any electrode configuration and the electrode model under the applied voltage on the brain tissue image model can be realized, and a technician can be effectively assisted in performing deep brain stimulation electrode configuration.

An implantable medical device to restore brain-controlled movement and sensation after neural injury. The device comprises a brain-computer interface capable of acquiring electrocorticogram (ECoG) signals recorded directly from the surface of the brain and uses the signals to enable direct control of paralyzed muscles, limbs or extremities while simultaneously receiving signals from external sensors and converting them into electrical stimulation patterns for the brain's sensory areas.

Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.

An auditory neural interface device for sound perception by an individual that may be used as a hearing aid. The auditory neural interface device includes a receiver configured to receive sound signals, a processor operably connected to the receiver and configured to encode a received sound signal as a multi-channel neurostimulation signal, and a neurostimulation device operably connected to the processor and configured to apply the multi-channel neurostimulation signal to a neurostimulation electrode of the individual. The neurostimulation signal is configured to directly stimulate afferent sensory neurons of the central nervous system of the individual and thereby to elicit, for each channel of the neurostimulation signal, one or more non-auditory, preferably somatosensory, perceptions in a cortex area of the individual. Each channel of the neurostimulation signal is associated with a different non-auditory perception.

The invention relates to a neurostimulation device for stimulating the brain of a patient by means of electrical stimulation signals, comprising: a) at least one electrode arrangement with multiple electrodes for delivering electrical stimulation signals to the tissue, b) at least one signal transmitter connected to the electrode arrangement, which is designed to generate and deliver electrical stimulation signals to the electrode arrangement.

The present invention relates to a reduced graphene oxide structure for stimulation and / or recording of the central and / or peripheral nervous system comprising a stack of layered, reduced graphene oxide flakes, wherein the reduced graphene oxide structure is electrochemically activated.

A surgical guide tool and methodology includes a non patient-specific platform including one or more supports for attaching to a body part of a subject. A non patient-specific block has a top planar surface and a bottom planar surface, and includes a guide aperture extending from the top planar surface to the bottom planar surface for guiding a surgical instrument in making at least one of a cut and a drill hole. An intermediate module is removably positioned between the platform and the block. The intermediate module has patient-specific dimensions such that the guide aperture has a desired alignment relative to the body part when the surgical guide tool is attached to the body part of the patient and the intermediate module is positioned between the platform and the block.

Disclosed are an implantable electrode, a stimulator and a control method therefor, an electronic device, and a storage medium. The implantable electrode comprises: a control module, the control module being configured to receive a gating instruction from a pulse generator and generate a switch control signal; an array switch, the array switch being configured to establish multiple gating channels according to the switch control signal; an electrode array module, the electrode array module comprising multiple contacts, each contact being configured to deliver electrical stimulation to a tissue in a patient via the gating channels established by the array switch, or collect physiological signals from a tissue in a patient. The switch control signal is used to isolate the stimulation contacts from the collection contacts.

The invention provides an electrode wire, a stimulator system and a computer readable storage medium, the electrode wire comprises a catheter, at least one electrode contact and a signal processing chip, each electrode contact is attached to the outer wall of the catheter, and each electrode contact is used for collecting a bio-electricity signal of a patient, and / or collecting the bio-electricity signal of the patient. Delivering electrical stimulation to the in vivo tissue of the patient according to the stimulation pulse signal; and the signal processing chip is arranged in the conduit. According to the invention, the signal processing chip is integrated in the electrode wire, so that the interference of external interference and stimulation pulse signals on bio-electricity signals is reduced.

Systems and methods are provided for creating a secure database execution environment. The system generates, by a database system executing on a secure enclave, attestation information. The system transmits the attestation information to a remote entity. The system obtains, by the database system executing on the secure enclave, one or more encryption keys in response to the remote entity authenticating the attestation information. The system performs, by the database system executing on the secure enclave, one or more database operations on encrypted data stored on the database system using the one or more encryption keys.