1117results about "Head electrodes" patented technology

The invention discloses a brain deep nerve stimulation method and system based on adaptive adjustment, and relates to the technical field of brain deep nerve regulation, and the method comprises the steps: collecting a local field potential signal of a brain deep target region of a target patient, and extracting a beta frequency band power spectrum density and a gamma frequency band phase synchronization index as neural activity characteristic parameters; determining an individual baseline value and a preset threshold value based on historical data, and outputting a stimulation adjustment trigger signal when the beta frequency band power spectral density exceeds the individual baseline value and the gamma frequency band phase synchronization index is lower than the preset threshold value; in response to the trigger signal, calculating an optimal stimulation parameter combination through a gradient descent optimization algorithm and executing nerve regulation; and monitoring the signal change after regulation and control, calculating a relative change rate and updating a threshold value. Through a two-parameter joint judgment mechanism and a threshold updating strategy, individualized adaptive adjustment of stimulation parameters is realized, and the stimulation accuracy and the treatment effect are improved.

The invention provides an intracranial neuron electrical stimulation system for treating epilepsy and other brain diseases involving epileptic seizure, which can immediately apply intracranial neuron electrical stimulation to the interseizure epilepsy activity in a personalized manner after detecting the interseizure epilepsy pattern each time. And the stimulation is activated by intracranial electroencephalogram (EEG) detection. The intracranial stimulation for epileptic activities in the epileptic seizure period continuously acts along with time, the forming process of an epileptic network can be blocked, the neuronal super-synchronization risk is reduced, and therefore the control effect on epileptic seizure is improved. The invention also includes the use of nerve adjustment biomarkers, thereby dynamically optimizing the detectability and providing more accurate overall assessment for the patient's treatment progress. Finally, according to the scheme, by detecting the intracranial EEG mode and the high-risk state mode (such as the epileptic state and the sudden accidental death risk in epilepsy) in the attack period, an instant alarm is given to the patient / nursing personnel, and it is ensured that safe treatment measures are taken for the patient in time.

An auditory neural interface device for sound perception by an individual that may be used as a hearing aid. The auditory neural interface device includes a receiver configured to receive sound signals, a processor operably connected to the receiver and configured to encode a received sound signal as a multi-channel neurostimulation signal, and a neurostimulation device operably connected to the processor and configured to apply the multi-channel neurostimulation signal to a neurostimulation electrode of the individual. The neurostimulation signal is configured to directly stimulate afferent sensory neurons of the central nervous system of the individual and thereby to elicit, for each channel of the neurostimulation signal, one or more non-auditory, preferably somatosensory, perceptions in a cortex area of the individual. Each channel of the neurostimulation signal is associated with a different non-auditory perception.

The present invention relates to a reduced graphene oxide structure for stimulation and / or recording of the central and / or peripheral nervous system comprising a stack of layered, reduced graphene oxide flakes, wherein the reduced graphene oxide structure is electrochemically activated.

A neurostimulation system may include an implantable neurostimulator. An implantable neurostimulator may include a first sensor configured to sense internal data relating to a symptom of a neurological movement disorder of a patient. An implantable neurostimulator may include an internal stimulator configured to provide an internal stimulation output to an internal target area of a patient. An implantable neurostimulator may include a first wireless communication device configured to communicate internal data with a network. A neurostimulation system may include a wearable neurostimulator. A wearable neurostimulator may include a second sensor configured to sense external data of a patient. A wearable neurostimulator may include an external stimulator configured to provide an external stimulation output to an external target area of a patient. A wearable neurostimulator may include a second wireless communication device configured to communicate external data with a network and receive internal data from the network.

The invention provides an implantable retina photon nerve repairing method and device, and relates to the field of implantable nerve regulation and control. The method comprises the following steps: acquiring a target image in a current visual field of a user based on external wearing equipment; adopting an edge detection algorithm to extract visual key features in the target image; based on the visual key features, time control pulse coding is adopted to generate a target stimulation pattern; performing neural feedback acquisition based on the target stimulation pattern, and acquiring neural electrical activity information through a feedback electrode preset on an implanted chip; based on the neural electrical activity information, the target stimulation pattern is dynamically adjusted through an adaptive optimization algorithm to perform optic nerve repair. The problem that a traditional implantable retina photon nerve repairing method is poor in retina photon nerve repairing effect is solved.

An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

A method of facilitating a skill learning process or improving performance of a task, comprising: determining a brainwave pattern reflecting neuronal activity of a skilled subject while engaged in a respective skill or task; processing the determined brainwave pattern with at least one automated processor; and subjecting a subject training in the respective skill or task to brain entrainment by a stimulus selected from the group consisting of one or more of a sensory excitation, a peripheral excitation, a transcranial excitation, and a deep brain stimulation, dependent on the processed temporal pattern extracted from brainwaves reflecting neuronal activity of the skilled subject.

Occipital lobe stimulation device comprising normal looking glasses having a frame portion with side portions and lens portions, provided together with a battery-powered plurality of Light-Emitting Diodes (LEDs) fixed around an anterior periphery of the frame portion for emitting photons of light to reflect off of an object in the outside world, and a plurality of photoreceptors dispersed across and retained in the lens portions, the photoreceptors being connected via wires to corresponding inverters in the side portions which are also wire connected to output devices on a strap an enabling connection to corresponding input devices surgically implanted and connected to the user's occipital lobes, for transmitting image information relating to the object to the user's occipital lobes to enable the user's brain to make use of the information.

A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.

Mandibular repositioning devices have a maxillary piece and a mandibular piece each of which is configured to cover a user's teeth. The maxillary piece has a right back teeth portion and / or a left back teeth portion and a driver flange protruding laterally outward from either or both thereof. Each driver flange has a driving side with a convex surface. The mandibular piece has a protrusive flange extending cranially therefrom and positioned with an engaging side thereof engaged against the driving side of the driver flange. The engaging side of the protrusive flange has a concave surface which mates with the convex surface of the driver flange when the mouth is closed and is in continuous contact thereagainst as a user moves their jaw downward, thereby providing gradual arcuate incremental forward mandibular movement as the concave surface of the protrusive flange smoothly glides against the convex surface of the driver flange.

A method and system for protecting electrode arrays while implanted on a brain including a flexible electrode array including non-penetrating cortical surface microelectrodes, a ceramic layer covering the electrode array and a polymer layer adjacent the ceramic layer, wherein the ceramic layer and the polymer layer hermetically seal the electrode array. The ceramic layer can be configured to exhibit sufficient flexibility to allow the electrode array to be implanted using minimally invasive surgical techniques, while still hermetically sealing the electrode array from a biological environment.

Systems and methods for patient guided neuromodulation therapy are disclosed. An exemplary system comprises a processing system and a memory. The memory may store instructions executable by the processing system to receive a medication schedule from a patient associated with neuromodulation therapy. The instructions may be executable by the processing system to send queries related to symptoms and side effects experienced by the patient. The instructions may be executable by the processing system to determine a parameter for a period of time of medication efficacy. The instructions may be executable by the processing system to determine a change in the parameter for the period of time.

Presented herein are techniques for reducing distortions in noise cancellation systems, including but not limited to body noise cancellation filtering systems. In one aspect, a method is provided. The method comprises: receiving at least one input signal at a noise cancellation system; and processing the at least one input signal using the noise cancellation system to generate a noise cancellation output signal, wherein the noise cancellation system is controlled by a variable filtering strength parameter that is a function of a level of the at least one input signal.

The present disclosure provides generally for a therapeutic oral device for assessing one or more health aspects of a user and / or alleviating one or more health conditions of a user, and associated methods for using the device. The device may comprise a hard palate portion, a mouth guard portion, and a tongue retainer portion. The hard palate portion may comprise one or more materials. The hard palate portion may also comprise a composite of materials. The mouth guard portion may comprise one or more components that provide stability and maintain the position of the therapeutic oral device within the mouth of a user. The tongue retainer portion may comprise an airway and a predetermined length. In some embodiments, the therapeutic oral appliance may comprise a mandibular mouth guard portion.

A system may include a neurostimulator and a processing system configured to provide a stimulation effects map by testing stimulation parameter sets from a plurality of available stimulation parameter sets, acquiring clinical effect data indicative of a patient response to electrical energy delivered to the tissue using at least a first subset of the tested stimulation parameter sets, acquiring sensed data indicative of a sensed response to the electrical energy delivered to the tissue using at least a second subset of the tested stimulation parameter sets, and evaluating parameter sets from the plurality of untested stimulation parameter sets including for each of the evaluated parameter sets, determining an estimated response by estimating at least one of the patient response or the sensed response to the electrical energy using the acquired clinical effect data and the acquired sensed data. A stimulation parameter set may be chosen based on the map.

An illustrative insertion management system may be configured to provide, as a first input to a machine learning model, geometric model data specific to a recipient of a cochlear implant and representative of a geometrical model of a cochlea of the recipient, provide, as a second input to the machine learning model, procedure data representative of one or more contextual attributes of a lead insertion procedure in which an electrode lead is inserted to the cochlea of the recipient, and generate, based on an output of the machine learning model that takes into account the geometric model data and the procedure data, procedure assistance data configured to assist a user in performing the lead insertion procedure.

Disclosed herein are methods and devices for transvascular placement of electrodes on a surface of a brain or in deep brain structures for the purpose of neuromodulation. The device can comprise a delivery catheter comprising a lumen. The device can comprise a piercing assembly extending through the delivery catheter, wherein the piercing assembly comprises a piercing assembly catheter and a needle. The device can comprise one or more electrodes configured to contact the brain tissue; and wherein the piercing assembly catheter comprises an opening in a wall thereof such that when the delivery catheter and the piercing assembly catheter are positioned within a vessel, the needle extends through the opening to puncture a vessel wall.

The invention provides a child migraine transaural vagus nerve stimulation therapeutic apparatus, which comprises a controller main body, and is characterized in that a microprocessor chip is arranged in the controller main body and is used for processing signals, controlling stimulation parameters and monitoring working states; the receiver main body is internally provided with a high-sensitivity wireless signal receiving module, is connected with the controller main body and is used for receiving a wireless signal sent by the stimulator, converting the wireless signal into an electric signal and transmitting the electric signal to the controller main body; the interior of the ear canal electrode comprises a protective cylinder and a round head, the round head is arranged in the controller body, the ear canal electrode relates to the technical field of medical instruments, the electrode designed according to the structural characteristics of the ears of the children can be accurately matched with the ears of different children, the accuracy and effectiveness of transaural vagus nerve stimulation are guaranteed, and the safety of the children is improved. The protective cylinder and the round head capable of being adjusted in all directions of the auditory meatus electrode and the auricular conchae electrode are flexibly adjusted through the molding rod, so that the attaching degree of the electrode and the ear is higher, a stimulation signal can be more effectively transmitted to the vagus nerve of the ear, and the treatment effect is improved.

The invention discloses a pig brain deep brain stimulation DBS electrode planning and reconstruction system and method, and belongs to the technical field of medical image processing and neurosurgery path planning. An automatic registration module based on a magnetic resonance (MR) image and a pig brain standard map is used for accurately identifying a target brain region; the in-target optimal electrode trajectory planning module based on principal component analysis (PCA) and the electric field simulation module based on a Hodgkin-Huxley model are used for optimizing the treatment effect and predicting the tissue activation volume (VTA); and a multi-modal hybrid registration module based on postoperative computed tomography (CT) and preoperative MR images, which is used for accurately reconstructing the actual position of the electrode. According to the invention, through combination of automatic and data-driven planning and accurate postoperative verification, the accuracy, reliability and efficiency of electrode implantation in pig brain DBS research are significantly improved.

The invention discloses a closed-loop vagus nerve stimulation system capable of cooperating with rehabilitation exercise. The closed-loop controller is used for collecting an external signal related to animal movement as a gating signal, processing the signal and generating a control instruction; the vagus nerve stimulator is used for receiving the control instruction of the closed-loop controller, adjusting stimulation parameters and outputting vagus nerve stimulation pulses; the wireless communication module is used for realizing wireless connection between the closed-loop controller and the vagus nerve stimulator and ensuring rapid transmission of a control instruction; the motion signal acquisition device is used for acquiring external signals related to animal motion; according to the invention, the problem of output misalignment of existing small equipment under a high load is obviously improved through a four-stage cascaded constant-current pulse generation architecture; meanwhile, based on a naked pulse infrared direct drive protocol and an MCU highly integrated processing chain, the timing sequence matching precision requirement of vagus nerve stimulation pulses and rat rehabilitation exercise actions is ensured.

Methods, systems, and devices, including computer programs encoded on a computer storage medium are provided for optimizing neurostimulation therapy for treatment of neurological and neurodegenerative diseases. Joint dynamic causal modeling and biophysics modeling are used for optimization of the stimulation targets and parameters. In particular, methods of performing neuromodulation to suppress b-band oscillations in the brain of a subject are provided.

An apparatus for electrical stimulation of tissues includes four electrodes that include a first pair of electrodes and a second pair of electrodes. The first and second pair of electrodes are each configured to contact a person and to convey AC current between the respective pair of electrodes through tissue of the person. The four electrodes are positioned approximately in the shape of a square where the first pair of electrodes and the second pair of electrodes are each positioned at opposite vertices of the square. The first pair of electrodes and the second pair of electrodes are configured to be positioned such that their AC currents are simultaneously conveyed through a target tissue of the person and are configured to stimulate the target tissue.

The invention relates to a depression electroencephalogram large model intervention system and method based on invasive electroencephalogram, and relates to the field of biomedical engineering and medical instruments, the depression electroencephalogram large model intervention system comprises an SEEG signal acquisition module used for recording electroencephalogram signals at a preset sampling rate through an implantable deep electrode; the brain region segmentation module is used for mapping the electrode contacts to preset brain region numbers; the spatial-temporal feature extraction module is used for extracting features of each brain region contact signal; the contribution degree calculation module is used for calculating the contribution degree of each brain region to the depressive symptom and normalizing the contribution degree; and the target spot output module is used for screening the brain region with the top contribution degree as a depression causing core target spot and generating a three-dimensional coordinate. According to the method, the intervention efficiency is improved, the side effect occurrence rate is reduced, and the method has multi-modal model adaptability and large sample driven generalization ability.

Provided are systems, methods, and devices for providing mediation or alleviation of sleep disorders and insomnia. Systems may include an interface, processing devices, and a controller. The interface is configured to obtain measurements from a brain of a user with sleeping disorders and insomnia. A first processing device is configured to generate multiple brain state parameters characterizing one or more features of a brain state of the user. A second processing device is configured to generate models of the brain of the user based on the plurality of brain state parameters and the plurality of measurements, and determine, using the models and training data comprising one or more mediation data points, a mediation procedure for reducing one or more symptoms of the sleeping disorder or insomnia. The mediation procedure is provided to one or more entities, and one or more control signals are generated by the controller based on the mediation procedure.

An apparatus, including an array of electrodes and an implantable therapeutic substance reservoir, wherein the apparatus is an implantable portion of a cochlear implant, the apparatus is configured so that the therapeutic substance reservoir extends from a location behind an ear canal of a human between a mastoid bone and skin of the human to the cochlea when the apparatus is fully implanted in a recipient, and the reservoir is completely integrated into the implantable portion of the cochlear implant.

A method of sleep disordered breathing care using specific patient information for a first patient to determine a probability of a particular collapse pattern for an upper airway and / or a therapy outcome, and based on the determination, performing further evaluative procedures and / or implementing therapy.

Systems, devices, and methods for intracranial access through vasculature (e.g., the superior sagittal sinus and / or the middle meningeal artery) to deliver devices on or near a brain of a patient. The system includes a catheter and a perforating element for puncturing the dura such that the distal portion of the catheter can be positioned in or near the subdural space. Devices that can be delivered include, for example, brain-computer interfaces (BCI) devices, intracranial pressure monitoring (ICP) devices, biopsy devices, or devices for injection or aspiration of fluid materials.

The invention discloses a visual reconstruction adjustment method and system, and the scheme comprises the steps: carrying out the stimulation threshold testing of all electrodes in an electrode array one by one, and obtaining the threshold range of each electrode through combining with the first feedback information of a tester for the stimulation threshold testing; performing a stimulation matching test based on the threshold range of each electrode, and adjusting and determining a mapping relationship between the stimulation parameter of each electrode and the visual perception data in combination with second feedback information of the tester for the stimulation matching test; and determining model parameters of the visual reconstruction model based on the mapping relation. According to the scheme, the mapping relation between the stimulation parameters and the visual perception data is adjusted and determined in combination with the real feedback of the testers, stimulation for the testers is more personalized and accurate, the perception difference between different testers can be better quantified for the same test process of the electrodes, and the test efficiency is improved. And the adaptation effect of the visual reconstruction model and a tester is improved.