700results about "Head electrodes" patented technology

A neurostimulation system may include an implantable neurostimulator. An implantable neurostimulator may include a first sensor configured to sense internal data relating to a symptom of a neurological movement disorder of a patient. An implantable neurostimulator may include an internal stimulator configured to provide an internal stimulation output to an internal target area of a patient. An implantable neurostimulator may include a first wireless communication device configured to communicate internal data with a network. A neurostimulation system may include a wearable neurostimulator. A wearable neurostimulator may include a second sensor configured to sense external data of a patient. A wearable neurostimulator may include an external stimulator configured to provide an external stimulation output to an external target area of a patient. A wearable neurostimulator may include a second wireless communication device configured to communicate external data with a network and receive internal data from the network.

An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

A method of facilitating a skill learning process or improving performance of a task, comprising: determining a brainwave pattern reflecting neuronal activity of a skilled subject while engaged in a respective skill or task; processing the determined brainwave pattern with at least one automated processor; and subjecting a subject training in the respective skill or task to brain entrainment by a stimulus selected from the group consisting of one or more of a sensory excitation, a peripheral excitation, a transcranial excitation, and a deep brain stimulation, dependent on the processed temporal pattern extracted from brainwaves reflecting neuronal activity of the skilled subject.

A method and system for protecting electrode arrays while implanted on a brain including a flexible electrode array including non-penetrating cortical surface microelectrodes, a ceramic layer covering the electrode array and a polymer layer adjacent the ceramic layer, wherein the ceramic layer and the polymer layer hermetically seal the electrode array. The ceramic layer can be configured to exhibit sufficient flexibility to allow the electrode array to be implanted using minimally invasive surgical techniques, while still hermetically sealing the electrode array from a biological environment.

An apparatus, including an array of electrodes and an implantable therapeutic substance reservoir, wherein the apparatus is an implantable portion of a cochlear implant, the apparatus is configured so that the therapeutic substance reservoir extends from a location behind an ear canal of a human between a mastoid bone and skin of the human to the cochlea when the apparatus is fully implanted in a recipient, and the reservoir is completely integrated into the implantable portion of the cochlear implant.

A method of sleep disordered breathing care using specific patient information for a first patient to determine a probability of a particular collapse pattern for an upper airway and / or a therapy outcome, and based on the determination, performing further evaluative procedures and / or implementing therapy.

Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.

An oral appliance for a user may include a body and a stimulator. The stimulator may include an electrode arranged on or embedded within the body. The stimulator may be in contact with a muscle of a tongue of the user. The stimulator may be configured to stimulate the muscle of the tongue with a stimulation signal to produce contraction in the muscle of the tongue.

A computer-implemented method and system includes a head-mounted wearable device having two current electrodes that delivers an input alternating current over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating current. A measurement validation module applies a Hilbert transform or a Cramer-Kronig test to the voltage difference measurements to generate a validated time-series impedance spectrum. A head fluid dynamics module fits the validated time-series impedance spectrum to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

Presented is a system and method for implanting a flexible electrode array in a biological organ. The system includes an electrode implant tool that includes an elongate rod and an electrode implant assembly having a plurality of attachment members. The electrode implant assembly further includes a ring member connected to each of the attachment members. A variable magnetic field generator is arranged in the ring member. The system uses electromagnetic force to temporarily strengthen the flexible electrodes allowing the penetration into the brain.

Embodiments of present disclosure provide systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for administering deep brain stimulation (DBS), and for evaluating the efficacy and efficiency of DBS for the treatment of neurological conditions (e.g., Parkinson's disease).

Systems and methods for adjusting neural therapy patterns of a neuromodulation system in response to each of patient events and passage of time. Initial stimulation parameters are set and used to start a stimulation period. As time passes or events occur, the neuromodulation system adjusts the stimulation parameters according to a preset temporal pattern. Further examples include handling of patient requests for therapy changes, and acute testing for complex stimulation patterns.

The present application belongs to the technical field of neural interfaces, and specifically, to a neural interface having an auxiliary structure. The neural interface includes at least one flexible electrode and at least one auxiliary structure, and the flexible electrode is assembled to one side of the auxiliary structure. The present application provides a neural interface, in which the auxiliary structure has rigidity, and the flexible electrode is detachably assembled to the auxiliary structure, so that the flexible electrode can be easily implanted into neural tissue with the assistance of the auxiliary structure, and then the auxiliary structure can be removed to leave only the flexible electrode in the brain tissue. The flexible electrode can adaptively deform according to the expansion and contraction state of a blood vessel, thereby reducing damage caused by implantation.

A pathway planning apparatus includes a processor configured to plan a pathway for implanting an electrode lead into a brain of a patient, wherein the planned pathway satisfies the following condition: if the electrode lead is implanted into the brain of the patient according to the pathway, the electrode lead is capable of simultaneously making contact with an anterior limb of an internal capsule and a nucleus accumbens in one hemisphere of a brain of the patient. The pathway planned by the pathway planning apparatus enables the electrode lead to simultaneously deliver the electrical stimulation to the anterior limb of the internal capsule and the nucleus accumbens such that a combined electrical stimulation therapy is achieved, which has a better effect of treating diseases such as addictive behaviors, depressive disorders, and obsessive-compulsive disorders.

The invention relates to a nerve interface device based on a transparent organic thin film transistor and a manufacturing method thereof. The device comprises a substrate, a first electrode layer comprising a plurality of source electrodes, a plurality of drain electrodes and a plurality of first electrodes, an organic semiconductor layer, a first insulating layer, a second electrode layer comprising a plurality of gate electrodes and a plurality of second electrodes, an interconnection wire layer, a biological electrode layer and a packaging layer which are sequentially arranged from bottom to top, a plurality of neural interface units are arranged in the device, each neural interface unit comprises a plurality of transistors, at least one capacitor and two biological electrodes, each transistor comprises a source electrode, a drain electrode, a gate electrode, an organic semiconductor layer and a first insulating layer between the transistor electrodes, two polar plates of each capacitor are respectively a first electrode and a second electrode which are opposite in position; the material of each layer of the device is a transparent flexible material. The device is low in cost, large in area, high in channel number, long in service life, and high in time and spatial resolution.

The present invention provides a stimulation and recording neural probe (100) at least comprising: a substrate (10); a stimulation and recording array (12), said stimulation and recording array (12) including at least one single-layer or double-layer solution-gated graphene field effect transistor (SG-GFET) (14) for recording brain signals of a patient, and at least one electrode (16) for applying electrical stimulation to a brain tissue and / or recording brain signals of the patient; and metal tracks (18, 20) for the at least one electrode (16) and the at least one single-layer or double layer SG-GFET (14), encapsulated in respective first and second encapsulation layers (22, 24). The invention further provides a method of manufacturing a stimulation and recording neural probe, such as the neural probe described above. Still further, the invention provides closed-loop system (200) for brain stimulation and recording comprising a control unit (202) and a stimulation unit (204), the stimulation unit (204) comprising at least one neural probe as described above.

Sensing an evoked response to electrical stimulation of target tissue of a patient in conjunction with an intra-luminal electrode. The intra-luminal electrode may be implanted in a blood vessel or similar lumen proximal to the target tissue and the sensed signals and / or delivered stimulation may pass through the blood vessel. or other lumen, walls. In some examples the evoked response may be an evoked compound action potential (ECAP), which may also be evoked resonant neural activity (ERNA). The electrical stimulation may elicit a measurable response indicative of a thought pattern or neural state that would otherwise be undetectable using a non-evoked biopotential.

An endovascular therapy system includes an endovascular device. The endovascular device includes an elongated body configured to be introduced into vasculature of a patient. The endovascular device includes a coil structure at a distal portion of the elongated body. The coil structure includes at least a first coil portion and a second coil portion. The first coil portion can be configured to carry a plurality of electrodes. The second coil portion can be formed from a coiled wire such that the second coil portion together with the coiled wire defines a coiled coil. The coiled wire can extend distally of a distal end of the first coil portion and be configured to anchor the elongated body and the coil structure within the vasculature of the patient.

DC offset compensation is provided to equate the DC values of the inputs to sense amp circuitry used to sense tissue signals in a stimulator device. When a DC offset is present at the inputs to the sense amp circuitry, the stimulation circuitry is controlled to remove this DC offset, which can occur in different ways. In one example, charge imbalanced pulses are provided to the inputs of the sense amp circuitry, the stimulation electrodes, or to other electrodes. Control of the stimulation circuitry can occur using a DC offset compensation algorithm programmed into control circuitry of the stimulator device. Using the algorithm, measurements indicative of the DC offset are used to determine charge imbalanced pulses, with the measurements being made by shorting the inputs together, and then releasing the input to reestablish the DC offset.

A probe for insertion into a brain tissue includes a tubular body having an inner lumen and at least two carbon fiber electrode threads (CFETs) extending through the inner lumen of the tubular body. Each CFET includes a carbon fiber having a proximal portion and a distal portion. The proximal portion of the carbon fiber is coated with a polymer. The distal portion of the carbon fiber is exposed to allow direct contact with the brain tissue. The carbon fiber of each CFET has an aspect ratio between 100 and 1500.

This document discusses neurostimulation devices, systems, and methods. A neurostimulation system receives a physiological target region for the neurostimulation and one or more optimization criteria for the neurostimulation of the target region. The neurostimulation system determines a likelihood of finding a stimulation configuration solution using a first optimization algorithm according to the physiological target region, determines a likelihood that the stimulation configuration solution is a better solution than what would be found by a second optimization algorithm and selects the first optimization algorithm or the second optimization algorithm according to the determined likelihood. The neurostimulation system recurrently changes stimulation parameters according to the selected optimization algorithm to determine the stimulation configuration solution based on the one or more optimization criteria and presenting the stimulation configuration solution to a user. The neurostimulation system comprises: a stimulation control circuit to deliver the neurostimulation according to a specified stimulation configuration, the stimulation configuration including multiple stimulation parameters; a port to receive a designation of a target region for the neurostimulation; a user interface configured to receive one or more optimization criteria for the neurostimulation of the target region; and a programming control circuit configured to perform the optimisation.

An electrode lead for artificial implantation in a cochlear system includes a tube having an interior volume and an outer peripheral surface; a plurality of stimulating electrodes disposed on a distal portion of the electrode lead; a ground electrode disposed on a proximal portion of the electrode lead for providing a current return path for stimulating current generated by the plurality of stimulating electrodes, wherein the ground electrode is annular and secured to the outer peripheral surface around the outer peripheral surface of the tube; and a ground lead extending within the interior volume of the tube to the ground electrode and electrically connected to the ground electrode through an opening in the wall of the tube. The ground electrode includes a first end portion, a central portion axially adjacent the first end portion, and a second end portion axially adjacent the central portion, wherein an outer surface of the central portion is radially elevated relative to an outer surface of the first end portion and an outer surface of the second end portion so as to form a step at a boundary between the first end portion and the central portion and a step at a boundary between the second end portion and the central portion, respectively.

A medical robot system, including a robot coupled to an end effector element with the robot configured for controlled movement and positioning. The robot system includes a robot base having a display, a robot arm coupled to the robot base, wherein movement of the robot arm is electronically controlled by the robot base. The end-effector is coupled to the robot arm, containing one or more end-effector tracking markers. The system also includes a plurality of dynamic reference bases (DRB) attached to multiple patient fixture instruments, wherein the plurality of dynamic reference bases include one or more tracking markers indicating a position of the patient fixture instrument in a navigational space. The system also includes a first camera system and a second camera system, the first and second camera systems being able to detect a plurality of tracking markers.

Systems and methods for selective sensing of evoked responses (ERs) and using the ERs to guide neuromodulation are disclosed. -An exemplary system comprises at least one multi -electrode lead, an electrostimulator to provide electrostimulation to a. neural target, a. sensing circuit to sense ERs to electrostimulation, and a controller circuit. In response to electrostimulation delivered to the neural target in accordance with a stimulation setting via a. stimulating electrode, the controller circuit can collect ERs from each of a group of sensing electrodes selected from and less than an entirety of the electrodes on the lead. The selected electrodes can be distinct from the stimulating electrode, or within a specific proximity to the stimulating electrode. The controller circuit can use a comparison of the sensed ERs to acceptance criterion to aid in lead placement and stimulation programming.

Devices, systems, and techniques are described for generating and presenting recommended ratings for different potential stimulation electrodes. An example system includes a memory configured to store a user interface, telemetry circuitry, and processing circuitry coupled to the memory and the telemetry circuitry. The processing circuitry is configured to generate a first screen presenting a representation of the plurality of electrodes and a signal quality indication for at least one of the plurality of electrodes based on the received signal information for presentation via the user interface. The processing circuitry is configured to obtain, via the first screen, a selection of one or more of at least one of the plurality of electrodes as a stimulation electrode. The processing circuitry is configured to program, via the telemetry circuitry, the implantable medical device to provide electrical stimulation according to a stimulation procedure defining a stimulation electrode.

A non-invasive vagus nerve stimulation apparatus comprising a pair of headphones, a vagus nerve stimulator; one or more cardiac and / or brain activity sensors; and a controller; wherein the pair of headphones includes a pair of spaced apart ear-covering portions and a headband which connects the spaced apart ear-covering portions; the vagus nerve stimulator is carried by one of the ear-covering portions and includes a first arm which carries a cathode and a second arm which carries an anode; the or each cardiac and / or brain activity sensor senses activity within the body of a user and signals relating to the cardiac and / or brain activity are transmitted from the or each electrical activity sensor to the controller; and wherein the controller is carried by the pair of headphones, processes the signals relating to the sensed cardiac and / or brain activity and controls the vagus nerve stimulator to electrically stimulate the vagus nerve.

This disclosure relates to systems and methods for the electrokinetic (EKF) delivery of therapeutic and cosmetic agents to oral tissues, including but not limited to enamel, dentin, cementum, gingiva, and mucosa. More specifically, it relates to modular, low-current dental treatment platforms configured to deliver active agents across or into oral tissues using flexible electrodes, voltage ramping logic, and optionally insulating or stabilizing structures.

An example of a system for delivering neurostimulation may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration. The stimulation control circuit may be configured to specify the stimulation configuration, and may include volume definition circuitry and stimulation configuration circuitry. The volume definition circuitry may be configured to determine one or more test volumes, determine a clinical effect resulting from the one or more test volumes each being activated by the neurostimulation, and determine a target volume using the determined clinical effect. The stimulation configuration circuitry may be configured to generate the specified stimulation configuration for activating the target volume.

Systems and methods for remotely monitoring the charging of an implantable pulse generator (IPG) are described. Data related to charging of the IPG is sent to a remote server. The data can be analyzed to determine various charging practices, for example, the frequency and duration of charging sessions, how well the patient aligns their external charger with the IPG, how low the patient allows their battery to drain between charging sessions, etc. Algorithms can be used to identify inefficient charging behaviors so that the patient and / or clinician can be alerted.

Devices, systems, and techniques are disclosed for predicting remaining life of medical devices. For example, a system may include an elongated member configured to be implanted within a patient, wherein the elongated member is configured to be coupled to an implantable medical device (IMD), the IMD configured to deliver therapy to the patient via the elongated member. The sensor may be carried by the elongated member and configured to provide a signal indicative of deformation experienced by the elongated member. The IMD may generate an alert indicative of predicted remaining device life and / or modify therapy delivery based on the signal indicative of deformation.