869results about "Magnetotherapy using coils/electromagnets" patented technology

A coil configuration and method for transcranial magnetic stimulation enabling stimulation of deep regions of the brain without excessively stimulating the cortex is provided. The coil configuration utilizes at least one coil to produce an off-plane magnetic field to enhance the magnetic field from a top TMS coil. In one configuration at least a single variable position coil referred to as the Variable Halo Coil and positionable vertically and / or angularly is used.

A system for administering transcranial magnetic stimulation in which two or more coils are applied to the patient's body. The coils each may emit a magnetic field which when positioned in one or more configurations result in field overlapping. Magnetic field overlap achieves therapeutic effects otherwise difficult, or impossible, to achieve from traditional single coil TMS devices.

A neurophysiological magnetic stimulation (NMS) method includes obtaining motor thresholds over one or both motor strips adhered to the patient's head or the equivalent anatomic region for treatment of non-brain, nervous system disorders. The method further includes applying magnetic stimulation coils to a therapeutic target region of the patient's brain, brainstem, spinal cord, or peripheral nervous system and applying NMS in increasing amplitudes as tolerated over the course of treatment.

The delivery of neurostimulation to a subject using a closed-loop neurostimulation device (e.g., using a brain stimulation device to provide neurostimulation to a subject's brain) is controlled based on a global optimization-based temporal prediction framework. As a result, the brain stimulation device (e.g., a transcranial magnetic stimulation (“TMS”) device) is synchronized with the ongoing neural state (e.g., brain state) in real time. For instance, a brain recording is analyzed to extract the brain process of interest (e.g., frequency of brain oscillations) and used train a prediction algorithm. After that, a stimulation stage is implemented, in which the individual brain state is analyzed in real-time, the occurrence of the biomarkers (e.g., brain oscillation phase) is predicted, and the stimulation is triggered at the expected time.

The invention relates to a transcranial magnetic stimulation high-precision positioning method, device and equipment based on optical navigation. Comprising the steps of selecting non-coplanar reference points based on a three-dimensional brain model of a patient, obtaining image coordinates and physical coordinates of all the reference points, carrying out corresponding point matching through the image coordinates and the physical coordinates, calculating and generating an optimal rigid transformation matrix, carrying out target registration error calculation, and realizing registration of an image coordinate system and a physical coordinate system. And according to the registered brain tissue conductivity parameters, calculating electric field space distribution induced by the transcranial magnetic stimulation coil in a target brain area, dynamically correcting stimulation target point coordinates of the virtual coil, and according to a completed coordinate system registration result, dynamically displaying the position and direction of the virtual coil corresponding to the transcranial magnetic stimulation coil on the three-dimensional brain model. And synchronously updating the brain slice view based on the corrected target point coordinates, and highlighting the actually stimulated brain region boundary. According to the method, adaptive neural navigation is driven through electric field remapping, and compensation target point correction is achieved.

The invention discloses a transcranial magnetic navigation and curative effect evaluation system based on electroencephalogram power spectrum analysis, particularly relates to the technical field of electroencephalogram signal processing, and is used for solving the technical problem that existing transcranial magnetic stimulation treatment lacks interference evaluation and stimulation path optimization on a cortical collaborative area. According to the method, electroencephalogram signals of a testee in a resting state and a task state are collected, phase-amplitude coupling indexes between frequency bands are extracted, a frequency-crossing coupling matrix is constructed, a nested chain structure with modulation direction consistency is identified, a stable resonance channel group is extracted from a channel intersection set to form a collaborative active region, and the collaborative active region is constructed. And after mapping to a standard brain map, carrying out space matching with a TMS target spot, evaluating an interference risk level, formulating a stimulation avoidance strategy, recording side reactions during treatment, and constructing a curative effect scoring window in a normalization manner, so as to realize synchronous optimization of stimulation planning and curative effect evaluation.

The invention discloses a transcranial magnetic stimulation target region recommendation method based on craniocerebral position estimation. The method comprises the following steps: constructing a face key point cloud based on binocular stereo vision; reconstructing the face key point cloud into a cranial surface model by using a pre-trained generative model; the method comprises the following steps: collecting magnetic resonance imaging data of patients with various diseases, establishing a transcranial magnetic stimulation target region standardized template with disease specificity, and determining a stimulation target region of each disease in a standard space; and based on the transcranial magnetic stimulation target region standardization template, mapping the corresponding stimulation target region from the standard space brain region to the scalp of the patient according to the disease type of the patient so as to realize recommendation. According to the method, the graph neural network is innovatively combined with the SHAP algorithm, the scientificity and interpretability of target spot selection are improved, important brain region target spots are obtained by calculating the contribution value of classification model features to classification decision of each sample, and then intervention target spots are sorted and selected to obtain an optimal treatment target spot recommendation scheme.

A neurostimulation system that has a programmer which has a power supply and processors with processing circuitry and a neurostimulation device which has power supply, processors and communication circuitry for providing communication with a neurostimulation device as well as communication circuitry for communication with the programmer. The neurostimulation system is configured to deliver treatment to a patient in accordance with a clinician prescribed protocol of a regimen. The neurostimulation system compares a delivered therapy treatment which has a treatment protocol to a defined treatment protocol of a prescribed treatment and adjusts the prescribed treatment stimulation parameters to compensate for a difference between the delivered neurostimulation therapy treatment and the prescribed treatment protocol for closely approximating the prescribed treatment protocol.

Provided herein are methods of treating a patient comprising providing a medical apparatus comprising an external system and an implantable system, implanting the implantable system, and delivering at least one of power or data to the implantable system with the external system. The external system comprises: at least one external antenna configured to transmit a first transmission signal to the implantable system; an external transmitter configured to drive the at least one external antenna; an external power supply; and an external controller. The implantable system comprises: at least one implantable antenna configured to receive the first transmission signal from the first external device; an implantable receiver; at least one implantable functional element configured to interface with the patient; an implantable controller; an implantable energy storage assembly; and an implantable housing surrounding at least the implantable controller and the implantable receiver. Medical apparatus are also provided.

The invention belongs to the technical field of transcranial magnetic stimulation coil design, and particularly provides a transcranial magnetic stimulation coil design method and system based on an inverse boundary element method.The method comprises the steps that firstly, a stream function calculation formula based on the inverse boundary element method and a regulation and control mechanism of current density constraint on wire spacing are deduced; and completing the design of the rat frontal and parietal lobe targeted stimulation coil. Aiming at the frontal top lobe area of a rat, a reverse method of an inverse boundary element method is adopted, the interference of the coil on experimental observation is reduced, and a small cambered surface TMS coil is designed. Compared with a circular coil and an 8-shaped coil of a conventional human body commercial coil which is reduced in equal ratio, the half-value volumes of the coil are respectively reduced by 79.78% and 57.14%, and the focusing degree of stimulation is remarkably improved; meanwhile, by adding the current density constraint, on the premise that the influence on the stimulation effect is small, the minimum distance between the wires is increased to 1.02 mm from 0.39 mm, and the feasibility of coil winding is ensured.

The invention discloses a transcranial magnetic stimulation positioning system based on a deep effect brain region, and the system comprises the steps: obtaining the data of a tested magnetic resonance image, which comprises a resting state functional image and a high-resolution T1 structure image; performing data preprocessing on the function image and the structure image, and establishing an individual space; the deep effect brain region template is converted to an individual space through nonlinear registration, and a target region of interest is defined; calculating functional connections between voxels of the deep effect brain region and the cortical region by adopting a Granger causality analysis method based on wavelet transformation; and screening Top block masses according to the functional connection strength, calculating the gravity centers of the Top block masses, and determining individualized stimulation targets in combination with the skull surface distance. According to the method, spontaneous brain activity function variation of the brain of an individual and the brain signal propagation direction are fully considered, accurate positioning of different individual levels is achieved, relatively stable cortex stimulation targets are obtained, and therefore the clinical curative effect of TMS is optimized.

The invention discloses a transcranial stimulation magnetic therapy coil navigation method, a transcranial stimulation magnetic therapy coil navigation system, a storage medium and equipment. The method comprises the following steps: acquiring three-dimensional structure information of the head of a target object, magnetic resonance imaging (MRI) data of an individual target object, or three-dimensional model data obtained by matching from a general MRI template library; real-time surface geometric information of the head of the target object is collected through an infrared optical tracking system; performing registration fusion on the three-dimensional structure information and the real-time surface geometric information, and generating an individualized three-dimensional brain model synchronized with a real space coordinate system on a navigation interface; the spatial position and posture of the optical marker fixed on the magnetic therapy coil are tracked in real time through an infrared optical tracking system and correspondingly mapped to the individualized three-dimensional brain model, and visual navigation of the magnetic therapy coil relative to the brain anatomical structure is achieved. Through the individualized three-dimensional navigation and real-time visualization technology, the problems that a traditional TMS is low in positioning precision, invisible in operation and poor in treatment repeatability are solved.

A system and method for integrated magnetic resonance imaging (MRI) and electroencephalogram (EEG) is described. The system includes an integrated radiofrequency (RF)-EEG cap that includes an EEG cap comprising a first layer of material containing a first plurality of holes that provide placeholders configured to receive EEG electrodes and an RF cap comprising a second layer of material containing a second plurality of holes and a plurality of RF coils fixed onto the second layer of material. The system also includes one or more fasteners configured to co-register the second plurality of holes to the first plurality of holes and to removably secure the RF cap to the EEG cap.

The invention relates to the technical field of spinal cord injury repair, and discloses a multi-mode nerve regulation electric acupuncture control system for spinal cord injury repair, a patient evaluation module is used for establishing a personalized spinal cord injury model of a patient and evaluating the current nerve function state and rehabilitation potential of the patient to obtain a nerve function evaluation result; the parameter setting module is used for setting multi-modal stimulation parameters in electroacupuncture treatment; the signal processing module is used for collecting local field potential of a spinal cord injury area and electromyographic signals around the injury in real time, preprocessing the collected signals and extracting time-frequency characteristics of the signals. The evaluation module is used for inputting the time-frequency characteristics of the signals into an electro-acupuncture evaluation model, evaluating the neural pathway in real time through the electro-acupuncture evaluation model and outputting an evaluation result; the adjusting module is used for adjusting the frequency, waveform and current intensity parameters of the electroacupuncture needle based on the evaluation result and a Q-learning algorithm, searching an optimal electroacupuncture needle parameter combination and feeding back the optimal electroacupuncture needle parameter combination to the electroacupuncture needle; according to the invention, the pertinence and effectiveness of treatment are improved.

The disclosure relates to devices and methods for applying a magnetic field on a body of a patient. The time-varying magnetic field may applied to a brain of the patient. The disclosure provides a method of finding the position suitable for application of the magnetic field to the brain. The devices and methods of the disclosure may be suitable for reducing of food craving.

The invention discloses an MEP automatic measurement and threshold discrimination method and system based on a mechanical arm. The MEP automatic measurement and threshold discrimination method comprises the following steps: constructing a scalp hotspot probability distribution map based on a brain map; dividing the hotspot scalp map into a plurality of sub-regions, and selecting candidate points from the plurality of sub-regions to obtain a candidate scalp stimulation point list; carrying out transcranial magnetic stimulation according to a point position sequence of the candidate scalp stimulation point list, simultaneously collecting a motor evoked potential signal triggered by each stimulation, and simultaneously collecting a motor evoked potential signal triggered by each stimulation; preprocessing and feature extraction are carried out on the collected motor evoked potential signals, whether stimulation evokes effective MEP response or not is judged through a response judgment method, and a candidate point-MEP response database is formed; screening an optimal motion hotspot point location in the candidate area, and taking the optimal motion hotspot point location as a target site; and searching an individualized resting motion threshold value on the optimal motion hotspot point location.

The invention relates to the technical field of magnetic therapy, and discloses a multipoint dense fine magnetic therapy device which comprises a shell. The bracket is arranged in the shell, and the bracket is provided with an assembling hole which is through up and down; the coil surrounds the periphery of the bracket; the plurality of magnetic needles are arranged in the assembling holes, the magnetic needles are provided with annular grooves which surround the magnetic needles and are perpendicular to the length directions of the magnetic needles, the space between every two adjacent annular grooves is filled with a fixing structure used for relatively fixing the adjacent magnetic needles, the space occupied by the fixing structures in the iron core is extremely small, the electromagnetic induction efficiency is high, and the magnetic needles cannot move relatively; the structure is stable in the production process, and production and long-term use are facilitated; the fixing structure can be provided with a pipeline for fluid circulation and also occupies a small space; when the magnetic needle is electroplated, the ring groove can provide a fixing position, and the electroplating process is convenient to fix.

The invention discloses a control device and computer equipment for a brain health therapeutic apparatus, and relates to the technical field of brain stimulation control, and the method comprises the steps: synchronously collecting an fMRI activity map, sMRI data and whole-brain voxel-level DTI data of a subject, extracting a cortex target region to be stimulated, and reconstructing and generating a triangular mesh model; non-linear registration is carried out on whole-brain voxel-level DTI data and the sMRI space, and a target region vertex direction field is generated; calculating a direction field average direction and a direction field covariance of the direction field at the vertex of the target region; if the covariance of the direction field does not exceed a preset covariance threshold value, controlling the brain health therapeutic apparatus to perform magnetic stimulation operation on the cortex target region according to the average direction of the direction field; and if the direction field covariance exceeds a covariance threshold, screening a first target region vertex sector and a second target region vertex sector, and controlling the brain health therapeutic apparatus to perform time division multiplexing vector scanning between sectors. Therefore, the accuracy of targeted stimulation and the individual suitability are greatly improved.

The invention relates to the field of medical treatment, and discloses a method for treating chronic insomnia by percutaneous magnetic stimulation of stellate ganglion block, which comprises the following steps: preprocessing: determining the initial position of stellate ganglion, tissue initial parameters and initial stimulation parameters through multi-modal image positioning and initialization to obtain reference data; dynamic sensing: collecting neck tissue displacement data, temperature field data and electromyographic signals in real time, and calculating spatial position variation of stellate ganglions and time-varying parameters of tissue electromagnetic characteristics; and modeling optimization: constructing a time-varying electromagnetic field distribution model based on the reference data, the spatial position variable quantity and the time-varying parameters. The method comprises the following steps: acquiring neck tissue displacement, a temperature field and an electromyographic signal in real time through reference data, capturing a stellate ganglion space position change and tissue electromagnetic property time-varying rule, constructing a time-varying electromagnetic field distribution model, and solving target stimulation parameters adaptive to a real-time tissue state through an optimal control algorithm.

The invention discloses an optical and neural feedback multi-modal data analysis method for a nerve regulation target, and belongs to the technical field of cranial nerve treatment, and the method specifically comprises the steps: receiving a head movement instruction of a patient through an interactive interface, pausing transcranial magnetic stimulation after receiving the instruction, and switching to a head movement monitoring state; an infrared optical navigation device is combined with a magnetic resonance image to construct an individualized brain three-dimensional model, head position changes are tracked in real time, and autonomic nerve feedback signals are collected at the same time; synchronously aligning the head coordinates with the neural feedback signals to generate a multi-modal data set, and analyzing relevance to obtain real-time regulation and control parameters; the positioning and stimulation intensity of the transcranial magnetic stimulation coil are adaptively adjusted according to the parameters, and related information is displayed on a treatment interface; after the head of the patient finishes moving and is stable, a rapid re-calibration process is automatically triggered, high-precision monitoring is recovered, and magnetic stimulation output is reactivated; according to the invention, the treatment stability and adaptability are improved.

Offline prior to operation, an optimised control sequence is derived for a pulse system comprising a reactive circuit for generating electromagnetic pulses, such as a transcranial magnetic stimulation circuit, and cascaded switching modules for switchably connecting capacitive discharge elements to provide a multi-level output voltage for the reactive circuit. A discrete-time model predicts an electrical state of the pulse system. A target profile for an electromagnetic pulse is received. For respective time-steps of the control sequence taken in succession, an optimal path of switching states over a window of time-steps starting with the respective time-step is derived, optimising a cost function having a deviation cost contribution representing deviation of an electrical state of the pulse system predicted by the discrete-time model from the target profile over the window. The switching state of the determined path at the respective time-step is selected for the control sequence.

The invention discloses a task state brain-computer interface training system for closed-loop transcranial magnetic stimulation, and particularly relates to the field of cognitive rehabilitation assistion.The task state brain-computer interface training system comprises the steps that multi-channel electroencephalogram signals and brain function activation records are synchronously collected in the rehabilitation training process, task segments are divided, and frequency domain energy characteristics of all channels are extracted; identifying a state transition candidate segment based on the frequency band energy distribution change; the method comprises the following steps: constructing a cross-channel phase synchronization matrix, and inputting a graph convolutional neural network to generate an activation topology vector reflecting a brain region cooperation mode; the system constructs an activation state recognizer by taking a topological vector and a brain function activation label as supervision data, and realizes real-time judgment of different function states. The recognition result drives a stimulation parameter recommendation module, a preset stimulation strategy mapping table is inquired according to the recognition state, recommended stimulation parameters are dynamically generated and transmitted to a magnetic stimulation execution interface, and personalized closed-loop nerve regulation and control are achieved.

The invention provides a brain-computer interface-based TMS and VR collaborative rehabilitation training system, which is characterized in that a multi-mode collaborative positioning module is used for collecting VR interaction data and electroencephalogram data and determining the optimal stimulation state of a subject; the motion intention analysis module is used for matching a rehabilitation mode according to the collected data and in combination with the type of the subject; and the closed-loop rehabilitation interaction module is used for adjusting parameters of the TMS equipment according to the rehabilitation mode and stimulating the final stimulation area under the optimal stimulation state of the subject. For a mild stroke patient, the system dynamically monitors the plastic change of the autonomic nerve and adaptively adjusts the treatment parameters according to the plastic change of the autonomic nerve; for a severe stroke patient, the virtual reality situation is combined to effectively induce motor imagery and synchronously collect and analyze electroencephalogram signals, closed-loop nerve regulation is achieved, synchronous accurate intervention and curative effect optimization of the severe stroke patient are achieved, and an intelligent solution is provided for rehabilitation treatment of the nerve function of the severe stroke patient.

The invention provides a multi-waveform magnetic field generating device for magnetic hyperthermia. The multi-waveform magnetic field generating device comprises a power supply module, a BUCK voltage regulating circuit, a multi-waveform signal generating circuit, a power amplifying circuit, a series resonance inverter circuit, an induction coil, a water cooling module, a temperature acquisition module, a DSP microprocessor and a TFT display screen. The power supply module is combined with BUCK to supply power to the device; the multi-waveform signal generation circuit, the power amplification circuit and the series resonance inverter circuit are used for generating an alternating magnetic field to act on a magnetic medium to generate a heat effect and realize magnetic hyperthermia; the water cooling module is used for reducing the temperature of the induction coil; the temperature acquisition module acquires temperature data of a treatment area and performs output control on the Buck voltage regulation circuit by using the DSP microprocessor so as to regulate the output power of the power amplification circuit powered by the BUCK voltage regulation circuit and realize intelligent temperature control of the magnetofluid; the problems that in the prior art, a magnetic field generation device is single in induction waveform and poor in heat generation effect are solved.

The invention discloses a voice control-based augmented reality precise transcranial magnetic stimulation system, which comprises augmented reality equipment, a voice recognition and control module and transcranial magnetic stimulation TMS equipment, and is characterized in that a magnetic resonance structure image of a tested head is projected to a real head, precise intracranial intervention sites are visualized, precise placement of a TMS coil is guided online, and the accuracy of the TMS coil is improved. The accuracy of transcranial magnetic stimulation is effectively improved, and the TMS equipment can be controlled through voice to switch a preset stimulation target, a stimulation mode, stimulation duration and the like according to a testee; the operation platform is transferred from a far-end computer screen to a tested actual head, a transcranial magnetic stimulation practitioner only needs to place a coil according to a visual model, the operation difficulty is greatly reduced, dependence on expensive and non-portable existing neural navigation hardware is reduced, and the transcranial magnetic stimulation system has the advantages of being easy and convenient to operate, portable, movable, low in cost, easy to popularize and suitable for popularization and application. And the use efficiency and the application range of the TMS equipment are greatly improved.

The disclosure relates to devices and methods for applying a magnetic field on a body of a patient. The time-varying magnetic field may applied to a brain of the patient. The disclosure provides a method of finding the position suitable for application of the magnetic field to the brain. The devices and methods of the disclosure may be suitable for reducing of food craving.

The disclosure relates to devices and methods for applying a magnetic field on a body of a patient. The time-varying magnetic field may applied to a brain of the patient. The disclosure provides a method of finding the position suitable for application of the magnetic field to the brain. The devices and methods of the disclosure may be suitable for reducing of food craving.

Systems and methods can be implemented in which an electromagnetic charge is used to strengthen, tone, and firm muscle tissues. For example, the method may include receiving parameters for operation of a magnetic muscle stimulation device. The method may also include causing, based on the received parameters, a first alternating current having a first phase to flow through a first coil and generate a first time-varying magnetic field that induces a first electric charge in muscle tissue under a skin surface of a patient when the first applicator surface is positioned substantially on and parallel to the skin surface of the patient. The method may also include causing a second alternating current having a second phase to flow through a second coil in a similar manner. Optionally, a phase offset between the first and second phases may be adjusted to limit to a predetermined maximum electric charge.

The invention provides an intelligent compression device and method for maintaining the internal fistula function of a hemodialysis patient, and belongs to the technical field of intelligent compression. The device comprises a CMUT ultrasonic array, an errhysis sensor, a bioelectricity monitoring module, an infrared temperature sensing array, an AI intelligent decision module, a dynamic pressure adjusting system, an energy field intervention module and a microneedle drug delivery module. Through space-time alignment collection of multi-modal data, dynamic parameter optimization of an AI model and rapid cooperative response of an actuator, the internal fistula compression is spanned from experience dependence to accurate intelligence, and the hemostasis efficiency and the blood vessel protection effect are remarkably improved.

The disclosure relates to devices and methods for applying a magnetic field on a body of a patient. The time-varying magnetic field may applied to a brain of the patient. The disclosure provides a method of finding the position suitable for application of the magnetic field to the brain. The devices and methods of the disclosure may be suitable for reducing of food craving.