122 results about "Brainstem" patented technology

Certain examples provide a method of collecting and analyzing complex auditory brainstem response. The example method includes presenting at least one complex auditory stimulus to a subject and acquiring the subject's complex auditory brainstem response. The example method includes averaging complex auditory brainstem responses from the subject in at least one of a time domain and a frequency domain to form a collected response. The example method includes analyzing the collected response using a signal processor to process the collected response to provide a processed output and to adapt the response for comparison to the at least one complex auditory stimulus. The example method includes performing statistical computations on the processed output to generate visual and data feedback for a user.

A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) to the back of the neck of a human patient to provide regional neuro-affective therapy is disclosed. In certain preferred embodiments, the cannabinoid drug(s) are not psychoactive or substantially not psychoactive. In certain embodiments, the cannabinoid drug(s) are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream. In certain preferred embodiments, the cannabinoid drug(s) comprises cannabidiol.

An electrophysiological measurement method and system is provided for positioning an implantable transducer of a hearing instrument relative to a middle ear component or inner ear of a patient. The method and system employ electrophysiological measurement signals obtained in response to test signals applied to an implanted transducer. In one embodiment, the electrophysiological measurements are obtained by an electrocochleography measurement device that measures the cochlear summating potential and / or action potential responsive to test signals applied to an implanted transducer. In another embodiment, an auditory brainstem response measurement device is utilized to obtain electrical potential measurement signals responsive to test signals applied to an implanted transducer.

A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of a drug to the back of the neck of a human patient at the hairline in close proximity to and under or on the area of skin above the brain stem to provide regional neuro-affective therapy is disclosed.

A method and device for automatically assessing loss of hearing sensitivity and compression (recruitment) with user defined frequency resolution by means of extrapolated DPOAE I / O functions and ABRs as well as for automatically fitting hearing aids without any cooperation of the subject tested using a device having a display screen attached to a handheld device generating and collecting otoacoustic emission signals and brain stem response signals into a programmed with a clinical audiogram with fitting parameters for hearing aids calculated on the basis of assessed hearing threshold and compression and identifying the type of hearing required for the individual.

An apparatus and method for evaluation of hearing loss is disclosed. The apparatus and method use evoked Auditory Brainstem Responses (ABR) to determine if the subject is able to hear iteratively administered click stimuli. The present invention evaluates the sufficiency of the patient connections, namely earphones and electrodes, to the evaluation device. More particularly, the present invention determines if the earphones are detached or deformed, if the electrodes have been reversed, or if the electrodes have become detached.

A portable EEG (electroencephalograph) instrument, especially for use in emergencies and brain assessments in physicians' offices, detects and amplifies brain waves and converts them into digital data for analysis by comparison with data from normal groups. In one embodiment, the EEG electrodes are in a headband which broadcasts the data, by radio or cellular phone, to a local receiver for re-transmission and / or analysis. In another embodiment, the subject is stimulated in two modes, i.e., aural and sensory, at two different frequencies to provide the subject's EPs (Evoked Potentials), assessing transmission through the brainstem and thalamus.

A system and method for segmentation of anatomical structures in MRI volumes using graph cuts is disclosed. In this method, a template is registered to an MRI brain volume. The template identifies seed points of anatomical brain structures, such as the cerebrum, the cerebellum, and the brain stem, in the MRI brain volume. Any or all of the anatomical brain structures can be segmented using graph cuts segmentation initialized based on the seed points identified by the template. It is possible to segment each of the anatomical brain structures by performing a hierarchical three-phase segmentation process including brain / non-brain segmentation, cerebrum / cerebellum and brain stem segmentation, and cerebellum / brain stem segmentation.

A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) and a second therapeutically active agent(s) to the back of the neck of a human patient to provide regional neuro-affective therapy is disclosed. In certain preferred embodiments, the cannabinoid drug(s) are not psychoactive or substantially not psychoactive. In certain embodiments, the drugs are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream. In certain preferred embodiments, the cannabinoid drug(s) comprises cannabidiol.

An apparatus and method for evaluation of hearing loss is disclosed. The apparatus and method use evoked Auditory Brainstem Responses (ABR) to determine if the subject is able to hear repeatedly administered click stimuli. In order to optimize evaluation, the present invention uses normative data to accurately weight the auditory responses, so that evaluation will be possible in different or changing noise conditions.

The invention relates to a method for partitioning brainstem areas automatically from MR (magnetic resonance) sequence images. The method is used for partitioning the brainstem areas automatically and continuously from the human body encephalic MR sequence images, so as to offer technological bases for reconstruction of 3D model of the encephalic tissues to doctors to judge the state of an illness of the patient efficiently and intuitively. The method comprises steps of (1) preprocessing: carrying out gray level clustering analysis on all MR nerve sequence images, and clustering the gray levels of all the MR images to be processed to be five-level gray level images; (2) selecting seed point pixel, obtaining the outline border of the brainstem area of the first MR image through a neighbor region growing algorithm based on the image area growing rate; (3) roughly partitioning the current MR image through a block region growing method; (4) repartitioning the roughly partitioned MR images through logical judgment treatment and the region growing method; and (5) repeating the step (3) and the step (4) till finishing partitioning all MR images.

An electrophysiological measurement method and system is provided for positioning an implantable transducer of a hearing instrument relative to a middle ear component or inner ear of a patient. The method and system employ electrophysiological measurement signals obtained in response to test signals applied to an implanted transducer. In one embodiment, the electrophysiological measurements are obtained by an electrocochleography measurement device that measures the cochlear summating potential and / or action potential responsive to test signals applied to an implanted transducer. In another embodiment, an auditory brainstem response measurement device is utilized to obtain electrical potential measurement signals responsive to test signals applied to an implanted transducer.

An apparatus and method for evaluation of hearing loss is disclosed. The apparatus and method use evoked Auditory Brainstem Responses (ABR) to determine if the subject is able to hear click stimuli that are repeatedly administered. In order to facilitate efficient differentiation of the ABR from the accompanying noise, normative data is used to detect test conditions where physiological, non-physiological, and ambient acoustic noise would interfere with the progression of test.

Certain examples provide a method of collecting and analyzing complex auditory brainstem response. The example method includes presenting at least one complex auditory stimulus to a subject and acquiring the subject's complex auditory brainstem response. The example method includes averaging complex auditory brainstem responses from the subject in at least one of a time domain and a frequency domain to form a collected response. The example method includes analyzing the collected response using a signal processor to process the collected response to provide a processed output and to adapt the response for comparison to the at least one complex auditory stimulus. The example method includes performing statistical computations on the processed output to generate visual and data feedback for a user.

The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by administering an S-nitrosylating agent selected from the group consisting of ethyl nitrite, glutathione, nitric oxide, S-nitrosocysteine, S-nitrosoglutathione, S-nitro-N-acetyl cysteine. As shown in FIG. 1C the ability of endogenous SNOg to increase VE in freely behaving, conscious rates using whole-body plethysmography revealed that CSNO, GSNO and CGSNO (1 nmol each) caused equivalent increases in VE, whereas D-CSNO had no effect (left bar graph is the equivalent increases in VE, whereas D-CSNO had no effect (left bar graph is the control whereas the right bar represents administration of the respective SNO).

The invention relates to a device for determining acoustically evoked brain potentials in objective audiometry from electrodes applied to the head of a subject, where the device comprises a plurality of electrodes, i.e. at least one pickup electrode and a reference electrode, to be applied at different points of the head, where the electrodes are mounted on a structure in fixed positions in relation to each other, where the structure comprises at least one flexible cushion abutting the head of the subject around an ear, where the pickup electrode and the reference electrode are integrated in the flexible cushion.

A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.

Aspects of the invention include system and method for transmitting neural data extracted from an electrical signal of a non-human mammal to a human. The system includes an electrode implantable into the animal auditory nerve, brainstem, or midbrain of the non-human mammal, configured to record the electrical signal of the non-human mammal, the electrical signal being in the form of sequences of pulses or pulse trains encoding frequency information of the non-human mammal, a processing device electrically coupled with the electrode, configured to process the electrical signal and convert the processed electrical signal into a digital signal, a transmitting device electrically coupled with the processing device, configured to transmit the digital signal, and a receiving device electrically coupled with the transmitting device, configured to receive the transmitted digital signal, convert the received digital signal into a sensory output perceptible to the human, and apply the sensory output to the human.

A method of treating a disease state or condition in mammals other than humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) to the back of the neck region and / or spine to provide regional neuro-affective therapy is disclosed. In certain preferred embodiments, the cannabinoid drug(s) are not psychoactive or substantially not psychoactive. In certain embodiments, the cannabinoid drug(s) are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream or mousse. In certain preferred embodiments, the cannabinoid drug(s) comprises cannabidiol.

The invention discloses a manufacturing method of an artificial vestibular organ and a research method of vestibular nuclear electro-stimulation for the artificial vestibular organ. Head motion information is transmitted to a central nervous system through electro-stimulation of brainstem vestibular nucleus, and the novel artificial vestibular organ is developed. The artificial vestibular organic is made first, horizontal rotational signals are detected through an angular velocity sensor so as to modulate the frequency of electrical impulses, vestibular nerve endings of a dominant horizontal semicircular canal of an experimental animal are electrically simulated, horizontal rotation of eyeballs is caused, existing methods and devices are modified to deeply research brainstem vestibular nuclear electro-stimulation, basis for related clinical application and fundamental research of artificial vestibular organs in the future is laid, and high social and economic benefits are achieved.

A handheld apparatus and method for comprehensive hearing testing with pass / refer results applicable for large scale neonatal screening, adult screening, or full hearing diagnostic. The apparatus contains a signal processor, integral ear probe, and remote ear and scalp probes all packaged as a single handheld battery operated device. The apparatus preferably performs a range of tests, either independently or combined: otoacoustic measurements utilizing a novel digital signal processing method for evoked otoacoustic signal processing, auditory brain stem response test, tympanometry, and otoreflectance. Algorithms for automatic test sequence, and pass / refer indication for the tests are provided.

An apparatus and method for evaluation of hearing loss is disclosed. The apparatus and method use evoked Auditory Brainstem Responses (ABR) to determine if the subject is able to hear repeatedly administered click stimuli. In order to optimize evaluation, the present invention uses normative data to accurately weight the auditory responses, so that evaluation will be possible in different or changing noise conditions.

The invention discloses a comprehensive detection platform for auditory indexes of an auditory system transmission access, which belongs to the technical field of auditory medical apparatus and instruments and is characterized by comprising an A / D acquisition card, a brainstem AEP signal acquisition transmission access, an OAE signal acquisition transmission access and a stimulated sound generating circuit, wherein the A / D acquisition card is connected with an input end and a digital signal output end of a computer; the brainstem AEP signal acquisition transmission access consists of a body surface disc electrode, a probe and a first bioelectrical preamplifier which are orderly connected in serial; the OAE signal acquisition transmission access consists of a micro radio and a second preamplifier which are orderly connected in serial; and the stimulated sound generating circuit consists of a D / A acquisition card and a micro loudspeaker which are orderly connected in serial. The comprehensive detection platform has the advantage of comprehensively detecting two auditory indexes at the same time.

A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of caryophyllene to the back of the neck of a human patient to provide regional neuro-affective therapy is disclosed. In certain embodiments, the drugs are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream, gel, lotion or foam.

The invention discloses a method and device for determining the direction of a coronal view of a brain image. The method includes: reestablishing a center sagittal plane figure according to the brain image; segmenting a plurality of brainstem regions in the center sagittal plane figure; determining the rear edge direction of the brainstem in the brainstem regions; and taking a rear edge direction of the brainstem or a direction which is parallel to the rear edge direction of the brainstem as the direction of the coronal view. The device includes a reestablishment unit which reestablishes the center sagittal plane figure according to the brain image; a segmentation unit which segments the plurality of brainstem regions in the center sagittal plane figure; a direction determination unit which determines the rear edge direction of the brainstorm in the brainstem regions; and a direction establishment unit which takes the rear edge direction of the brainstem or the direction which is parallel to the rear edge direction of the brainstem as the direction of the coronal view. Through the direction of the coronal view of the brain image, determined by the method and device and parallel to the rear edge direction of the brainstem, demands for brain imaging scanning can be better met.

The AC and / or PC landmarks are identified in a midsagittal MRI image by firstly identifying structures in the brain (specifically the fornix and / or brainstem) as groups of pixels in a radiological image which have an intensity in ranges defined by one or more thresholds and which obey predefined geometrical criteria. The thresholds are varied until the predefined geometrical criteria are met. Initial estimates of the position of the AC and / or PC are derived from the identified structures. These estimates can be improved in various ways, especially by making use of axial and / or corona / radiological images in planes including, and / or proximate to, the initial estimated position of the AC and / or PC.