3211 results about "Dermatology" patented technology

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

Provided are a beauty instrument for improving the barrier function and / or the transparency of skin, a beauty instrument for promoting collagen production, and a beauty instrument for ameliorating sagging of the skin.　This needle beauty instrument has a part equipped with a needle-like projection and is used for improving the barrier function of skin, improving the transparency of the skin, promoting collagen production by the skin, or ameliorating sagging of the skin.

Provided herein are compositions that are useful in healing wounds and / or treating inflammatory skin conditions comprising (a) a copper-containing peptide; (b) an antioxidant; and (c) a cyclic oligosaccharide-based polymer, where the copper-containing peptide and the antioxidant form a complex. Further provided herein are methods for healing wounds and / or treating inflammatory skin conditions using the compositions of the disclosure.

The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, lipidosome and a preparation method and application thereof. The acne-removing composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 8 parts of nicotinamide, 1 to 5 parts of cortex magnoliae officinalis extract, 0.15 to 2.01 parts of glycyrrhizic acid, 0.1 to 2 parts of totarol and 0.01 to 0.15 part of hyssopus officinalis extract. The nano-carrier is adopted to wrap and deliver the acne removal composition, so that the solubility of the functional components is increased, the bioavailability of the functional components is improved, meanwhile, the irritation of the functional components is also improved, multi-target co-delivery and multi-mechanism acne removal are realized, and the acne removal composition has a remarkable acne removal effect.

The invention provides application of a turbellarian worm extract in preparation of a product for promoting wound healing, a biological agent for promoting the proliferation activity and / or migration ability of fibroblast NIH3T3, a biological agent for improving the wound healing rate and the decrustation time and a biological agent for improving the collagen fiber deposition type in the wound healing process. The biological preparation is used for promoting regeneration of skin appendage organs in the wound healing process. Wherein the extraction of the turbellarian worm extract comprises the steps of turbellarian worm cleaning, tissue crushing, alcohol extraction, centrifugal separation and concentration drying. The turbellarian worm extract has good capacity of promoting wound healing, and has the effects of effectively improving skin wound healing efficiency, shortening decrustation time, inhibiting scar formation in the wound healing process, promoting regeneration of skin appendage organs in the wound healing process and the like.

The invention discloses purified gastrodia elata polysaccharide as well as a preparation method and application thereof, and belongs to the technical field of extraction of active ingredients of gastrodia elata. The method comprises the following steps: (1) adding an alcoholic solution into gastrodia elata powder for reflux extraction, and collecting filter residues; (2) dissolving the filter residues in pure water, and performing ultrasonic extraction to obtain filtrate; (3) adding absolute ethyl alcohol into the filtrate for low-temperature alcohol precipitation to obtain crude gastrodia elata polysaccharide; (4) performing deproteinization treatment on the gastrodia elata crude polysaccharide; (5) purifying by using macroporous resin; (6) dialyzing the crude polysaccharide purified liquid in pure water; (7) purifying by using a first chromatographic column, wherein a filler is cellulose-based anion exchange resin; (8) purifying by using a second chromatographic column to obtain purified gastrodia elata polysaccharide; and the filler is sephadex. According to the present invention, the gastrodia elata crude polysaccharide is purified by using the five purification means, such that the high-purity gastrodia elata purified polysaccharide can be rapidly, stably and efficiently obtained.

The invention belongs to the technical field of cosmetic efficacy evaluation, and discloses a sunscreen efficacy evaluation method and application thereof, and the method comprises the following steps: building a blank group; establishing a model group; establishing a sample group; performing constant-temperature incubation on the blank group, the model group and the sample group for a first period of time, recording a swimming track, and calculating swimming distance increment and after-sun burning pain relieving efficiency of each group of zebrafish; performing constant-temperature incubation on the blank group, the model group and the sample group for a second duration, recording the tail fin and dorsal fin area of the zebra fish, and calculating the sunburn prevention efficiency; performing constant-temperature incubation on the blank group, the model group and the sample group for a third period of time, recording the head melanin area of the zebra fish, and calculating the anti-sunburn efficiency; and grading the sunscreen effect of the sample. The method disclosed by the invention has the advantages of low cost, short test period, high reproducibility, high visualization degree, intuitive and understandable test result and the like, and can be used for accurately grading the sunscreen effects of chemical sunscreen agents, water-soluble sunscreen cosmetics and raw materials thereof from the whole animal level.

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

The invention provides an acne-removing composition containing ceramide, a preparation method of the acne-removing composition and an acne-removing product, and the acne-removing composition is prepared from the following components in parts by weight: 5 to 10 parts of plant extract, 1 to 3 parts of ceramide, 1 to 3 parts of gentiopicroside-vitamin C eutectic, 1 to 3 parts of compound polysaccharide and 0.3 to 0.7 part of transdermal enhancer. The plant extract is prepared from a herba dendrobii fruticosae flower extract, a lasiocarpus trifoliatus extract and a hedera rhododendron extract in a mass ratio of 1: (1-3): (2-4); the compound polysaccharide is prepared from tremella polysaccharide, tamarind seed polysaccharide and ganoderma lucidum polysaccharide in a ratio of 1: (3-5): (0.5-0.8); the transdermal enhancer is prepared from a cucumber extract and a salvia miltiorrhiza root extract in a mass ratio of 1: (1-3). The plant extracts in the acne-removing composition take effect synergistically, the acne-removing effect is achieved from multiple aspects of bacteriostasis, anti-inflammation and oil control, the purpose of efficiently removing acnes without relapse is achieved, and the natural plant extracts are mild and non-irritant, do not cause burden to the skin and have good application prospects.

The invention relates to a whitening and soothing composition, a nano microemulsion containing the same and a preparation method of the nano microemulsion. The whitening and soothing composition comprises a litchi fruit extract, a quercus root extract, a malt extract and palmitoyl tripeptide-5. According to the functional composition, the litchi fruit extract, the oak root extract, the malt extract and the palmitoyl tripeptide-5 are creatively combined for use, so that the functional composition has excellent skin whitening and soothing effects, and the four components have an obvious synergistic interaction effect in the aspects of whitening and soothing the skin; the functional composition can be widely applied to cosmetics with related functions. The nano micro-emulsion prepared from the functional composition is subjected to shearing emulsification and then high-pressure micro-jet treatment, so that the prepared nano micro-emulsion is better in stability and better in appearance property, and the nano micro-emulsion can stably play a role in whitening and relieving for a long time.

The present invention relates to methods and compositions for treating hair loss or excessive hair shedding in a subject or for promoting hair growth in a subject. The present invention also relates to an orodispersible composition or a nasally administered composition for treating hair loss or excessive hair shedding in a subject or for promoting hair growth in a subject.

1. Name of the design product: Phototherapy Beauty Instrument (HY-80R). 2. Use of the design product: For phototherapy and beauty treatment of human skin. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Perspective view.

The invention relates to the technical field of daily chemicals, and particularly discloses a scalp oil control composition for preventing alopecia seborrhoeica as well as a preparation method and application of the scalp oil control composition. The scalp oil control composition is prepared from the following main components: nicotinamide, capryloyl glycine, piralinone ethanolamine salt, betaine salicylic acid, lemon peel extract, white willow bark extract and rice fermentation filtrate. All the components have a synergistic effect, and the effects of controlling oil, protecting hair and preventing alopecia seborrhoeica are achieved. The preparation method disclosed by the invention is simple and convenient, and the obtained product is high in bioavailability of active ingredients, good in hair care effect and low in irritation, has the effects of caring hair, strengthening hair roots, regulating scalp micro-ecology and preventing seborrheic alopecia, and can be widely applied to related washing and care products for preventing seborrheic alopecia.

The invention pertains to the technical field of biomedical engineering and pharmacology and, without being limited thereto, specifically relates to a composition that enables the healing of full-thickness and chronic wounds (particularly in the foot region) observed in individuals suffering from diabetic disease.

The invention relates to a composition with antioxidant and brightening effects and capable of delaying skin saccharification as well as a preparation method and application of the composition, and belongs to the field of cosmetics. The composition comprises an ormosia henryi bark extract, tetrahydrocurcumin, a mirabilis jalapa extracting solution, a surfactant, polyol, phospholipid and a solvent. The composition provided by the invention has good illumination stability and high-temperature stability, and the composition provided by the invention is high in bioavailability, and has good antioxidant and brightening effects and lipofuscin and RAGE level inhibition effects.

The invention relates to composition of urolithins comprising urolithins and pectin and formulations of urolithins, specifically chewable formulations, comprising urolithins and a gelling agent. The invention further comprises compositions and chewable formulations comprising urolithins in combination with other active ingredients and processes for the preparation of such compositions and formulations. The invention further comprises methods of using such compositions and formulations in the treatment of conditions and diseases and for the promotion of health and performance, such in the improving muscle function.

The invention relates to the technical field of medicines, and provides a lanosterol derivative as well as a preparation method and application thereof. The lanosterol derivative provided by the invention has a structural formula as shown in a formula I or a formula II. The lanosterol derivative provided by the invention has both fat solubility and water solubility, and can effectively permeate into a diseased region in a body, so that the medicinal availability is improved; results of the embodiment show that the solubility of the lanosterol derivative provided by the invention in water is obviously higher than that of lanosterol or 25-hydroxylanosterol, and the lanosterol derivative shows an obvious cataract treatment effect in animal in-vivo experiments and has a wide prospect in preparation of drugs for treating eye diseases or symptoms. # imgabs0 #

The invention relates to the technical field of daily chemical industry, and discloses a moisturizing and soothing composition and application thereof.The moisturizing and soothing composition comprises, by weight, 20-25% of C14-16 sodium olefin sulfonate, 20-25% of C14-16 sodium alkyl sulfonate, 20-25% of C14-16 sodium alkyl sulfonate, 10-20% of C14-16 0.3%-0.7% of a cationic polymer; a litchi pericarp extract; an aloe extract; and a rosemary extract; wherein the total weight percentage of the litchi peel extract, the aloe extract and the rosemary extract is 1.9%-3.3%. The components are compounded, the cationic polymer and the anionic surfactant are utilized to construct a deposition system, and the three plant extracts with specific total content are cooperated, so that the retention rate of active ingredients in scalp is effectively increased, and the problem that moisturizing and soothing ingredients are easy to wash away is solved. The invention also provides a preparation method combining hot preparation and cold preparation, and the stability of the system and the activity of the extract are ensured by homogenizing the phase A at high temperature and adding the phase E at low temperature. The composition can be used for preparing shampoo products for moisturizing or relieving scalp.

The invention relates to the technical field of lipidosome compounds, in particular to a cosmetic lipidosome compound with an anti-allergy effect and a preparation method of the cosmetic lipidosome compound. The preparation method of the cosmetic liposome compound with the anti-allergy effect comprises the steps of preparation of a wrapping modification modifier, preparation of wrapping modification liposome and preparation of the cosmetic liposome compound. Efficient allergy relieving is achieved through the synergistic effect of the hovenia dulcis thunb extract and the white willow bark extract. The former inhibits release of inflammatory factors and scavenges free radicals, the latter reduces synthesis of prostaglandin and promotes epidermal renewal, and the former and the latter form a dual anti-inflammatory network, cooperate with lipid, regulate water and oil and accelerate inflammation regression. Meanwhile, the two extracts are wrapped by lipidosome, and a modifier formed by zein and fucoidin is combined, so that the stability of the lipidosome is enhanced, the percutaneous delivery efficiency and the percutaneous absorption effect of the components are improved through multiple effects, and it is ensured that the active components effectively exert the anti-allergy effect.

The present invention relates to the technical field of daily chemical technology, and specifically provides a whitening and freckle-removing cream. The freckle-removing cream comprises the following components in parts by weight: water, glycerin, mineral oil, antioxidant microcapsules, polydimethylsiloxane, sodium ascorbyl phosphate, niacinamide, a plant compound extract, essence, and cetearyl alcohol. The present invention adds natural plant extract ingredients, which is safe and effective. A circulation device is used to promote the effective combination of active ingredients, so that the active ingredients can quickly penetrate into the inner layer of the skin, thereby improving the transdermal absorption ability of the active ingredients. A unique encapsulation technology is used to firmly adhere the active ingredients to the skin surface, thereby effectively lightening facial spots, removing dullness from the skin, and restoring luster.

The invention relates to the technical field of cosmetics, and discloses an oil-controlling acne-removing tea polyphenol composition, a preparation method and application thereof, the composition comprises 20-30 parts of tea polyphenol, 30-40 parts of capryloyl glycine and 50-60 parts of a solubilizing antioxidant; according to the composition, the normal-temperature water solubility of the capryloyl glycine is improved through the solubilizing antioxidant, the application range of the capryloyl glycine in water aqua is expanded, in addition, the solubilizing antioxidant can improve the oxidation resistance of the tea polyphenol and improve the stability of the tea polyphenol, the oil control and acne removal effects are remarkably improved when the composition is applied to water aqua cosmetics, and the product stability is high.

The invention relates to the technical field of hair dyes, and particularly discloses a mild hair dye capable of coloring quickly and a preparation method of the mild hair dye. The hair dye comprises an agent A and an agent B. The agent A comprises glycerin, cetostearyl alcohol, myristyl alcohol, flaxseed gum, a stevia rebaudiana extract, tea tree oil, fructo-oligosaccharide, a surfactant, an oxidation dye, a chelating agent, an antioxidant, an emulsifier, grease, a hair conditioner, essence, a pH regulator and water. The agent B comprises cetostearyl alcohol, an emulsifier, grease, glycerol, a chelating agent, a buffering agent, hydrogen peroxide, a stabilizer and water. The hair dye disclosed by the invention can shorten the hair dyeing time, so that the retention time of the hair dye on scalp and hair is shortened, and the irritation and damage of the hair dye to the scalp and the head are reduced.

A low-cost, in-line process for treating a fibrous web with a lotion is provided. The process generally involves passing a web through a nip formed by a pair of opposed surfaces, where one of the surfaces has been treated with a lotion having a penetration hardness greater than 5.0 mm. As the web passes through the nip, the lotion is transferred from one of the opposed surfaces to the surface of the web. In certain instances, the web may have a textured surface and only a portion of the web's textured surface is treated with a lotion.

The present invention relates to the technical field of cosmetics, and discloses a whitening and freckle-removing essence and a preparation method thereof. The whitening and freckle-removing essence is formed by mixing additives such as nicotinamide, EDTA, L-lactic acid, citric acid, baicalein inclusion complex, etc. The baicalein inclusion complex has a coated structure. Since the skin surface carries a negative charge and the coating layer of the baicalein inclusion complex contains chitosan, it can be adsorbed on the skin surface through electrostatic action, producing a sustained-release effect, and then targeted release, so as to improve the whitening effect of the essence. In addition, after being encapsulated, baicalein can have good compatibility with other substances in the formula. Moreover, the linolenic fatty acid chain in the structure of the chitosan derivative has excellent antioxidant, anti-inflammatory and other effects, which can reduce the phenomenon of scar formation on the skin due to inflammation.

A method of demulsifying a hydrocarbon emulsion, the method comprising adding one or more biosurfactants to the hydrocarbon emulsion.

The instant disclosure relates to methods for removing color from artificially colored hair. The methods include a two-step process: (I) applying a reducing composition to hair that has been colored with oxidation dyes and rinsing the reducing composition from the hair; and (II) applying an alkalizing composition to the hair and rinsing the alkalizing composition from the hair. The step can be carried out in either order. The methods effectively remove color from artificially hair in a quick and gentle manner without employing an oxidizing agent.

A system for dispensing hair care formulations including a communication device that includes processing circuitry capable of taking a photo of a user's hair, uploading the photo into an application on a communication device, applying an algorithm to the photo to detect one or more hair features, sensing one or more environmental conditions with one or more sensors, and recommending a hair care treatment regimen of one or more hair care formulas based on the one or more hair features, and the one or more environmental conditions. The system also includes one or more cartridges containing one or more hair care formulas, and a dispensing device configured to dispense one or more hair care formulas from the one or more cartridges based on the hair care treatment regimen.

The invention relates to the technical field of daily chemicals, in particular to a mousse type sunscreen cosmetic composition and a preparation method thereof. The composition is prepared from a solvent, a sun-screening agent, a humectant, a filling agent, an emulsifying agent, an emollient, a preservative, a skin protecting agent, a thickening agent, an antioxidant and a pH regulator. The mousse texture sun-screening agent provided by the invention is very light, and does not bring heavy or sticky feeling to the skin when being used, so that the skin feels natural and comfortable. The product has a light covering feeling on the skin, does not block pores, and is suitable for being used in hot weather or during sports. The mousse texture has good ductility, can be quickly and uniformly spread on the skin, does not need excessive friction, and reduces sunscreen dead angles caused by non-uniform smearing. The mousse is generally smooth in texture, suitable for being smeared in a large area and capable of conveniently and rapidly covering the whole body such as arms, legs and the back.

The invention relates to the technical field of cosmetics, and particularly discloses a mild and stable A alcohol composition, an A alcohol cosmetic and a preparation method of the A alcohol composition and the A alcohol cosmetic. The mild and stable A alcohol composition is prepared from the following components in parts by weight: 0.1 to 0.5 part of A alcohol; 0.7 to 2.7 parts of a coating component; 0.3 to 0.9 part of a soothing component; the coating component is prepared from glycerol distearate, polyglycerol-10 pentastearate, behenyl alcohol, glyceryl stearate citrate and a composition of polyglycerol-6 stearate; the soothing component is prepared from hydroxyphenyl propionamide benzoic acid, a citrus fruit extract and bisabolol. According to the mild and stable A alcohol composition, the anti-aging, repairing and other effects of the A alcohol are guaranteed, and the irritation problem of the A alcohol is solved.

The invention provides a compound nystatin ointment and a preparation method thereof, and relates to the technical field of medicine preparation, the compound nystatin ointment comprises active ingredients of nystatin, neomycin sulfate, triamcinolone acetonide and permethrin, and the formula comprises liquid paraffin, white vaseline, wool fat, hexadecanol, PEG-30 dipolyhydroxystearate and glyceryl monoisostearate. According to the compound nystatin ointment preparation prescription process disclosed by the invention, the phenomenon of ointment matrix layering in the use process of commercially available products is mainly solved. According to a pharmaceutical research test, the stability of the compound nystatin ointment is superior to that of a commercially available original development agent, the ointment body character and the stability of active ingredients can be kept under the conditions of high temperature, high humidity, low temperature, freeze thawing and illumination, the maximum single impurity content and the total impurity content in the product are not obviously increased, and the quality is controllable. And meanwhile, an in-vitro transdermal test (IVPT) accidentally finds that the retention amount of related active ingredients is higher than that of the original development agent, and the drug effect is obviously improved. Through clinical test research, the compound nystatin ointment disclosed by the invention can be used for effectively treating external otitis caused by bacteria sensitive to neomycin, fungi sensitive to nystatin and ear mites sensitive to permethrin of dogs and cats.