3227 results about "Skin care" patented technology

Camera and / or other sensor analysis of skin, used to diagnose and monitor health conditions. A computer, receiving skin data from a user, where the skin data is images and / or other data of the skin. The computer processes the skin data identify skin conditions, their status, and to compare the skin data with information indicative of health conditions that are not skin diseases. This can be done by finding similar skin data to other data received from other people who have specified health conditions and / or by looking for changes from previous images. The skin data can be captured by a smart phone camera (alone or with digital peripheral attachments) or a dedicated capture device such as a periscope, one way mirror, or cubicle. An augmented reality marking system can be used to mark areas on the user's skin to compare against other previous skin images and / or data.

The invention relates to the field of biological medicines, in particular to a facial anti-aging collagen peptide, a composition and an application of the facial anti-aging collagen peptide, and particularly relates to a 21-type recombinant humanized collagen peptide (ColpepA1 21) and an application of a composition of the 21-type recombinant humanized collagen peptide in anti-aging treatment and skin care. The recombinant collagen provided by the invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of the skin, reduce fine lines and wrinkles, and improve the compactness and elasticity of the skin.

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

The invention relates to the technical field of skin care, in particular to a collagen composition with anti-wrinkle and repairing effects and a preparation method. Comprising 1.5-4.5 parts of mixed collagen, 2.5-5 parts of mixed polypeptide and 4-8 parts of mixed extract, wherein the mixed extract comprises 1-2 parts of centella asiatica extract, 1-2 parts of polygonum cuspidatum root extract, 1-2 parts of bilberry fruit extract and 1-2 parts of bidens pilosa extract; the collagen is directly supplied to the skin to supplement collagen, and is mainly used for repairing the skin structure, increasing the density, elasticity and compactness of the skin and remarkably improving fine wrinkles and looseness; the polypeptide inhibits the expression of MMP-1; the natural plant active ingredients promote the expression of TGF-beta, enhance the activity of fibroblasts, accelerate the synthesis of collagen, prevent excessive oxidation of skin, repair skin inflammation, activate cell energy and delay skin aging.

The present invention relates to a skin care device including a lightweight handpiece. The skin care device comprises: a handpiece for skin treatment which comes into contact with the skin and stimulates the skin; a control body which is connected to the handpiece for skin treatment through a connection cable body and controls the operation of the handpiece for skin treatment; a driving force generating unit which is mounted inside the control body and generates a driving force; a handpiece operating body which is provided in the handpiece for skin treatment and operates by receiving the driving force from the driving force generating unit; and a driving force transmission unit for transmitting the driving force of the driving force generating unit to the handpiece operating body through the inside of the connection cable body. Since the driving force generating unit for operating the handpiece operating body is mounted on the control body, the weight of the handpiece for skin treatment is reduced, thereby greatly improving the convenience of a practitioner and the satisfaction of treatment during treatment, and simplifying the structure of the handpiece for skin treatment.

Disclosed is a skin care treatment device. The skin care treatment device according to an embodiment of the present invention includes: a main body; a suction header having a suction port, which comes into contact with skin, at an end portion protruding outward from the main body; a light irradiation module for irradiating the user's skin, which comes into contact with the suction port, with light that is generated when power is applied; a suction module that is provided inside the main body and applies negative pressure for raising a treatment site of the skin, which comes into contact with the suction port, to the suction port when power is applied; at least one optical sensor for sensing and measuring light that enters through an optical path formed at the end portion of the suction port which comes into contact with the skin; and a control unit electrically connected to the light irradiation module and the suction module. The control unit can selectively control the operation timing of the suction module by determining the contact state between the suction port and the skin on the basis of a measurement value detected by the optical sensor.

The present invention relates to a suction handpiece and a skin care device including same, the handpiece comprising: a handpiece body part having a negative pressure formation space open at a surface thereof that is to come into contact with the skin; an air suction pipe member positioned in the handpiece body part, and connected to a suction port of the negative pressure formation space and a vacuum device of a control body part; and a cream movement guide member, which is mounted at the suction port in the negative pressure formation space so as to guide, toward the lower side thereof, treatment cream moving toward the suction port along the inner surface of the negative pressure formation space and to block the cream from flowing into the suction port, and thus the present invention blocks the treatment cream from being suctioned into an air flow path by negative pressure during a treatment so as to prevent a clogging accident of the air flow path, thereby ensuring operation stability, increasing the durability of the vacuum device, and reducing the costs and time required to repair the air flow path clogged by the treatment cream.

The invention relates to an anti-aging oligopeptide for beauty and skin care, the oligopeptide has an amino acid sequence as shown in (X1) (R or K or H) G (D or E) # (X2), X1 represents one amino acid of G, A, V, L, I and P or represents that no amino acid exists, # represents one amino acid selected from A, V, D, E, N and Q, and X2 represents G and P or represents that no amino acid exists. The oligopeptide is a functional fragment of XVII type collagen, can induce in-vivo collagen synthesis or simulate a protein regulation function, has the effects of promoting cell self-cleaning, helping to remove aged skin cells, reconstructing skin rhythm, maintaining a good skin structure, resisting initial aging, promoting skin repair and regeneration, reducing fine wrinkles and the like, and is mild in action, free of side effects and free of toxic and side effects. The product has no obvious adverse reaction on human body, and is a good beautifying and anti-aging product.

Wearable modular mask systems for combination face and skincare diagnostics and therapeutics. Systems include devices that can be attached to wearable masks for diagnosis and treatment of skin conditions, diseases, and disorders, as well as for cosmetic improvements to the skin of the face and scalp.

Camera and / or other sensor analysis of skin, used to diagnose and monitor health conditions. A computer, receiving skin data from a user, where the skin data is images and / or other data of the skin. The computer processes the skin data identify skin conditions, their status, and to compare the skin data with information indicative of health conditions that are not skin diseases. This can be done by finding similar skin data to other data received from other people who have specified health conditions and / or by looking for changes from previous images. The skin data can be captured by a smart phone camera (alone or with digital peripheral attachments) or a dedicated capture device such as a periscope, one way mirror, or cubicle. An augmented reality marking system can be used to mark areas on the user's skin to compare against other previous skin images and / or data.

The invention discloses a cyclic hexapeptide for skin care and a composition and application thereof, and relates to the technical field of polypeptides, and the cyclic peptide has the following structure: Cyclo-[Arg-Arg-Gln-D-Met-Glu-Glu]. Specifically, the invention relates to the cyclic peptide or the salt thereof, or a composition of the cyclic peptide and the salt thereof, and application of the cyclic peptide and the salt in preparation of a composition for nursing or treating skin or mucosa.

The invention discloses a collagen composition for skin substrate repair and skin care application thereof, and the collagen composition comprises the following components: 1-3% of soluble III-type collagen, 1-5% of hyaluronic acid, 1-2% of plant extract, 0.1-0.5% of allantoin, 0.2-0.5% of dipotassium glycyrrhizinate, 1-5% of glycerol, 1-5% of butanediol, 1-5% of 1, 2-propylene glycol, 1-5% of 1, 3-propylene glycol, 1-5% of propylene glycol and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 1 to 2 percent of 1, 2-hexanediol, 0.1 to 0.5 percent of phenoxyethanol, 0.1 to 0.5 percent of ethylhexylglycerin, 0.1 to 0.5 percent of carbomer, 0.1 to 0.5 percent of triethanolamine and the balance of water. The collagen III is added, so that the problems of wrinkles and skin aging are remarkably relieved. According to the skin-care lotion, the oily composition and the water-based composition are reasonably proportioned, so that excellent moistening and moisturizing effects are provided, the moisture balance of the skin is favorably maintained, and the skin is kept soft and moist. The added plant extract, hydrolyzed protein and mineral substances not only nourish and repair the skin, but also can improve various skin problems, enhance the endurance capacity of the skin and avoid the condition that the skin wrinkles are increased during the period of stopping using.

The invention discloses a skin evaluation and skin care decision-making system and method based on AI drive, and belongs to the field of big data and artificial intelligence, and the system comprises a data collection module which is used for obtaining a skin image and user information; the skin evaluation module is used for performing skin state evaluation through multi-modal data fusion; the recommendation decision module is used for reinforcing learning to generate a personalized skin care scheme; the resource scheduling module is used for intelligently scheduling offline nursing resources; and the effect tracking module is used for acquiring the post-nursing skin image corresponding to the expected skin improvement period in the expected effect and comparing and analyzing the post-nursing skin image with the pre-nursing skin image to obtain a nursing effect. According to the method, skin state evaluation can be carried out through multi-modal data fusion, and a personalized skin care scheme is generated in combination with reinforcement learning.

The invention belongs to the technical field of cosmetics, and particularly relates to essence with anti-wrinkle, repairing and skin-brightening effects as well as a preparation method and application of the essence. The essence is prepared from the following components in parts by weight: 10 to 70 parts of herba centellae extract, 0.0015 to 0.04 part of crocus sativus extract, 0.5 to 2.5 parts of spirulina maxima extract, 0.015 to 0.2 part of radix gentianae extract, 0.1 to 1.5 parts of panthenol, 0.25 to 1.5 parts of leuconostoc / radish root fermentation product filtrate, 0.1 to 1.5 parts of carnosine and 0.21 to 5.3 parts of anti-wrinkle components. According to the essence, various effective components such as the centella asiatica extract, the spirulina maxima extract and the radix gentianae extract are matched for use, a unique composite formula is formed, all the components promote one another, the anti-wrinkle, repairing and skin brightening effects of the essence can be remarkably enhanced, and therefore all-around skin care is provided for consumers, and the essence has a good market prospect. The overall quality of the skin can be effectively improved.

The invention discloses herbal oil control essence. A component A comprises deionized water and sodium hyaluronate; the component B comprises methylpropanediol, a hyperforin perforatum flower / leaf / stem extract, cyclodextrin and a rehmannia chinensis root extract; the component C is prepared from water, butanediol, amur corktree bark extract, coptis root extract, radix sophorae flavescentis extract, rhus chinensis insect gall extract, cnidium monnieri fruit extract, zanthoxylum bungeanum fruit extract and camphor tree leaf extract; and the component D comprises 1, 2-hexanediol. The preparation method of the herbal oil-control essence comprises the following steps: S1, preparing raw materials; s2, preparing the component A; s3, preparing the component B; s4, preparing a component C; s5, a mixing process; and S6, adding a component D and carrying out post-treatment. The herbal components form a synergistic effect network and act on a skin grease secretion system in a targeted manner, grease secretion is balanced from the source by adjusting the biological activity of sebaceous gland cells, meanwhile, biological signal channels related to skin anti-inflammation, moisturizing and tightening are activated, and the multiple-effect-in-one skin care effect is achieved.

The invention provides an adenosine dihydroxysuccinate eutectic crystal and a preparation method and application thereof.In the adenosine dihydroxysuccinate eutectic crystal, the molar ratio of a dihydroxysuccinic acid molecule to an adenosine molecule is 1: (1-4), on the premise that the structure of adenosine is not changed, dihydroxysuccinic acid and adenosine are combined, the water solubility of adenosine is improved, and therefore the adenosine dihydroxysuccinate eutectic crystal is obtained. According to the preparation method, the adenosine which is difficult to dissolve in water is prepared into the water-soluble adenosine dihydroxysuccinate eutectic crystal, so that the water solubility of the adenosine dihydroxysuccinate eutectic crystal can reach 4%, the effects of the adenosine dihydroxysuccinate and the adenosine monomer are not damaged, and the adenosine dihydroxysuccinate and the adenosine monomer have a better synergistic effect; compared with a monomer and a simple mixture, the composition has better effects in the aspects of antibiosis, antioxidation, anti-aging, hair care, hair loss prevention and the like, and has a good application prospect in skin and hair care products.

The invention relates to the field of skin care and medical cosmetology, and discloses a long-acting moisturizing and barrier repairing type exosome active gel and a preparation method thereof, and the gel comprises the following components by mass: 2-5 parts of exosome; 3 to 7 parts of trehalose; 2 to 6 parts of glycerol; 1 to 2 parts of polyvinyl acrylate; 0.5 to 1.5 parts of octyl glucoside; 0.8 to 1.5 parts of sodium hyaluronate; 0.2 to 0.5 part of low molecular peptide; 1 to 3 parts of polyacrylamide; and 0.02 to 0.05 part of a tea polyphenol antioxidant. According to the invention, through synergistic repair of the exosome and the low-molecular peptide, dual moisturizing of the trehalose and the glycerol, a thickening system is innovated to improve the stability, and the tea polyphenol antioxidant is combined, so that deep repair, lasting moisturizing, skin feeling optimization and aging resistance are effectively realized, and multiple bottleneck problems of a traditional skin care technology are comprehensively solved.

The invention relates to the technical field of daily chemicals, in particular to a skin care matrix with skin micro-ecology regulating and hair loss preventing effects and cosmetics thereof. The invention discloses a skin care matrix with effects of regulating skin micro-ecology and preventing hair loss. Comprising the following components in parts by weight: 60 to 70 parts of galactose yeast-like bacterium fermentation product filtrate, 0.05 to 0.5 part of Chinese arborvitae twig and leaf extract, 0.05 to 0.5 part of citrus fruit extract, 0.05 to 0.5 part of white willow bark extract, 0.05 to 0.5 part of officinal magnolia bark extract, 0.05 to 0.5 part of lotus leaf extract, 0.05 to 0.5 part of sea buckthorn fruit extract, 0.05 to 0.1 part of ceramide NS / ceramide NG and 0.05 to 0.5 part of Italian helichrysum extract. 1.0 to 5.0 parts of lactobacillus / soybean extract fermentation product filtrate, 0.5 to 1.0 part of vitex trifolia fruit extract, 0.05 to 0.3 part of hydrolyzed keratin and 0.05 to 0.3 part of hydrolyzed vegetable protein; according to the skin care matrix, the microbial fermentation product and the plant extract are used as skin probiotics, and ceramide and other components are used as auxiliary materials to generate a synergistic effect, so that the skin care matrix shows excellent effects of balancing scalp micro-ecology, repairing hair follicles, refreshing and preventing hair loss on the premise of ensuring safety and mildness.

The invention discloses a function-enhanced recombinant fibronectin as well as a preparation method and application thereof. The amino acid sequence of the recombinant fibronectin is shown as SEQ ID No.3, and the recombinant fibronectin is formed by fusing a main structural domain FN III8-10 formed by combining human fibronectin mutated into proline at the 171st site with integrin and a main structural domain FN III12-14 formed by combining the human fibronectin with cell factors. The recombinant fibronectin provided by the invention has enhanced cell proliferation and adhesion promoting performance of human fibroblasts, shows excellent cell biological efficacy, can be efficiently expressed in pichia pastoris engineering strains, and has wide application prospects in the fields of skin care, beauty and tissue engineering.

The invention relates to the technical field of cosmetics, and particularly discloses a composition with after-sun repairing and whitening effects and a preparation method thereof. According to the present invention, various efficient components such as the ergothioneine compound, the acetylchitosamine, the nicotinamide, the sodium hyaluronate, the inositol, the aloe vera extract, the glycerophosphoinositide choline salt, the tetrahydromethylpyrimidine carboxylic acid, the oat beta-glucan compound, the citrus peel extract compound and the skin brightening agent are scientifically matched; according to the present invention, the excellent after-sun repairing and whitening effect is achieved, the comprehensive after-sun skin care is achieved, the skin state can be improved, and the skin health degree can be improved. The application creatively finds that when the glycerophosphoinositide choline salt, the citrus peel extract compound and the skin brightening agent are compounded, the effects of the composition in the aspects of after-sun repairing and whitening can be improved at the same time, and the comprehensive effect is relatively good.

The invention relates to the technical field of medical education, in particular to a virtual patient skin care teaching system with enhanced pathological features and a method thereof, the system comprises pathological feature generation, parameter control, physical modeling, intelligent evaluation and a multi-mode feedback module, and can edit and simulate various skin pathological features in real time, such as pressure sores and diabetic feet, so that the system can be applied to the field of medical education. The visual display of the lesion degree is realized through a five-segment color mapping system, the system also simulates percolate reflection and cuticle spalling, the sense of reality is enhanced, the intelligent assessment module provides risk assessment and healing prediction according to physiological and morphological parameters, the multi-modal feedback module integrates visual sense, tactile sense and user behavior feedback, the interactive experience is improved, and the system is suitable for popularization and application. And the adaptive optimization module dynamically adjusts system parameters according to user feedback and learning effects, and provides personalized teaching. Compared with a traditional method, the method is higher in parameter control precision, supports personalized teaching, and is of great significance to medical education.

The sunshade / shield structure invention is practical, portable, and effective in skin care protection and prevention of skin cancer. It can be made as a commercial use product with less portability features or a residential / consumer model which is portable and can be disassembled and reassembled quickly via pins and or shock cords like camping hike tents. Its aerodynamic design is wind resistant and porous so water during a storm won't pool and stress the frame. It can be made of metal materials that are powder coated or high-impact absorbing, UV-protected plastics. The ground frame / base can be extended in length or width for custom chair fitting and stability because the frame sleeves in and out. A sand or ground anchor can be used in the yard or on the beach instead of the ground stand. The leg post interfaces with both ground and sand anchor bases. The ground frame will have two roller wheels so moving will be easy. Tip the shade back and touch the wheels to the hard surface for easy relocating.

The invention relates to a skin care composition for improving female climacteric aging and application thereof, and the skin care composition for improving female climacteric aging comprises the following components: conotoxin peptide, bakuchiol, alfalfa extract and radix pseudostellariae extract, the weight ratio of the conotoxin peptide to the bakuchiol to the alfalfa extract to the radix pseudostellariae extract is (0.1-5): (0.1-3): (0.1-5): (0.1-3). By means of inhibiting neurotransmitters, regulating hormones and the like, skin health is enhanced, the problem of skin aging of menopause women is effectively solved, and the skin is tight and smooth.

The invention discloses a physiotherapy instrument and a skin care assembly, the physiotherapy instrument comprises a shell, a battery, a circuit board and two first electrodes, the battery and the circuit board are electrically connected and arranged in the shell, and the two first electrodes are exposed out of the shell; the battery, the circuit board and the two first electrodes are connected to form a micro-current circuit, the battery, the circuit board and the two first electrodes are connected to further form a charging circuit, and the micro-current circuit and the charging circuit are two mutually independent circuits; the micro-current circuit is configured to form a micro-current loop when the two first electrodes are in contact with the skin; and the charging circuit is configured to form a charging loop when the two first electrodes are in contact with the charging seat. Through the arrangement, the overall structure can be simplified, and the production cost is reduced.

The invention relates to a skin care composition containing white truffle and plant exosome and application thereof. The skin care composition containing white truffle and plant exosome comprises white truffle extract, chlorella exosome, DNA sodium, superoxide dismutase and fermentation product filtrate, the fermentation product filtrate comprises any one or a combination of at least two of lactobacillus / soybean milk fermentation product filtrate, lactobacillus / mung bean seed extract / sodium glutamate fermentation product filtrate, bifidobacterium fermentation product filtrate or saccharomycetes / rice fermentation product filtrate. According to the invention, the white truffle extract, the chlorella exosome, the DNA sodium, the superoxide dismutase and the fermentation product filtrate are creatively combined, and the composition has unexpected synergistic interaction in the aspects of inhibiting melanin synthesis, accelerating melanin metabolism and resisting oxidation and aging. The composition is mild in performance and free of irritation and toxic and side effects, and can be applied to cosmetic products more safely.

1. The name of this design product: Neck support (smiley face). 2. Purpose of the product of this design: a device for fixing during neck skin care. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

1. Name of the product of this design: Whitening cabin with spray assembly (SD‑0136). 2. Purpose of this design product: for beauty and skin care. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: combined use status diagram 1.

The invention provides a whole cortical action compound peptide, which comprises acetyl tetrapeptide-11, hexapeptide-9, palmitoyl hexapeptide-12, palmitoyl hexapeptide-14 and / or acetyl hexapeptide-1, and is characterized in that the whole cortical action compound peptide comprises acetyl tetrapeptide-11, hexapeptide-9, palmitoyl hexapeptide-12, palmitoyl hexapeptide-14 and / or acetyl hexapeptide-1; the compound peptide acts on epidermal basal layer keratinocytes, true epidermal junction (DEJ) structural proteins and / or dermal layer fibroblasts, and synergistically exerts a whole-cortex skin anti-aging effect on epidermal layer, basement membrane, dermal layer and / or nerve fibers. The compound peptide has the advantages of full-cortex three-dimensional anti-aging, layered precise targeting, multi-peptide scientific compounding, matrix synergy, clear action mechanism, efficient growth promotion of seven key proteins, remodeling of a true epidermis structure, low-concentration effect, mildness, no stimulation and the like, and is an advanced anti-aging scheme under a precise skin care trend.

The invention provides a skin care composition with an anti-aging effect and a preparation method and application thereof, and belongs to the technical field of beauty and skincare, the composition is characterized in that retinol, a polypeptide compound, ceramide, astaxanthin and resveratrol have a synergistic effect on component combination, so that all-around anti-aging is realized, and the skin care effect is good. According to the present invention, the raw materials are respectively adopted to provide effects of collagen generation promotion, muscle contraction wrinkle solving, barrier function enhancing, free radical scavenging, melanin formation inhibition and the like, the preparation method comprises the following steps: precise temperature control, suitable stirring mode, high-precision stirrer and other advanced technologies ensure uniform mixing of the components, inert gas protection and PID temperature controller retention of the activity and the effects of the components, in the aspect of application, the composition is reasonably added into face cream, emulsion, essence and facial mask, diversified requirements are met, deep nourishing, refreshing care, efficient permeation and instant effects are respectively provided, in a word, an efficient, safe and comprehensive anti-aging scheme is provided for consumers, aging signs are improved, and the composition is wide in prospect and high in value.

The invention discloses a whitening nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. The whitening nano-emulsion is prepared from the following components in percentage by weight: 2.0 to 10.0 percent of an emulsifying agent, 4.0 to 10.0 percent of an emollient, 3.0 to 8.0 percent of glycerol, 3.0 to 8.0 percent of butanediol, 0.5 to 3.0 percent of nicotinamide, 1.0 to 3.0 percent of a Soulixian extract, 0.5 to 3.0 percent of ascorbyl tetraisopalmitate, 0.3 to 3.0 percent of hydrogenated lecithin, 0.1 to 2.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 0.1 to 1.0 percent of SymSitive1609, 0.03 to 0.5 percent of a mulberry root extract, 0.03 to 1.0 percent of cerium oxide and the balance of water. The toothpaste is prepared from the following components in percentage by weight: 0.05 to 0.5 percent of tocopheryl acetate, 0.03 to 0.3 percent of stearyl glycyrrhetinic acid ester, 0.01 to 0.1 percent of poly gamma-sodium glutamate, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 1.0 percent of preservative, 0.01 to 0.1 percent of aromatic and the balance of water, wherein the total The prepared whitening nano-emulsion can solve the problems of excessive addition, difficult absorption and instability of active ingredients of cosmetics, can inhibit DPPH free radical activity, hydroxyl free radical activity and tyrosinase activity through the synergistic effect of all the components, achieves the effects of resisting oxidation, whitening, removing freckles, brightening skin and the like, and does not cause damage to the skin.