527 results about "Skin cell" patented technology

The invention relates to the field of microorganisms, in particular to bifidobacterium adolescentis YG3912, inactivated thalli, an extract, a culture, a culture supernatant, a fermentation product and / or a fermentation supernatant of the bifidobacterium adolescentis YG3912, an application of the bifidobacterium adolescentis YG3912 in preparation of a composition for promoting skin repair, reducing skin inflammation or allergy, improving skin quality and improving skin quality. The invention also relates to application of the composition in products for resisting skin aging and enhancing skin immune function. The bifidobacterium adolescentis YG3912 and the related products thereof have the advantages that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are high in skin cell repairing capacity, skin inflammation relieving, inhibiting or eliminating capacity and remarkable in skin aging resisting capacity, so that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are expected to be used for skin health care such as skin repairing, inflammation relieving and light aging resisting, and the bifidobacterium adolescentis YG3912 and the related products thereof have remarkable application value and market potential.

The invention belongs to the field of cosmetic detection, and discloses a cosmetic and cosmetic raw material sunscreen function evaluation method and application. According to the evaluation method, a sunscreen effect test is carried out on a test sample by using a non-contact administration device, wherein the test sample is a cosmetic finished product or a diluted cosmetic raw material; the test comprises evaluation of in-vitro sunscreen effect by skin cells, evaluation of in-vivo sunscreen effect by a zebra fish embryo model and result evaluation. According to the method, the sunburn-resistant effect is evaluated through expression of beta-galactosidase in human dermal fibroblasts and / or secretion of collagen, the sunburn-resistant effect is evaluated through the survival rate of human keratinocytes, the DNA damage condition or inflammatory factor secretion and the lethal / teratogenic condition of zebra fish embryos, and multi-layer and all-around sunburn-resistant effect evaluation is achieved. The method provided by the invention is suitable for evaluating the sunscreen function of various sunscreen products, has accuracy and practicability, and provides an important technical basis for research and development, quality control and performance optimization of sunscreen cosmetics.

The invention discloses an anti-aging composition containing ergothioneine, glutathione and fish collagen, relates to the technical field of anti-aging compositions, and aims to solve the technical problems that a traditional anti-aging composition lacks attention to the aspects of cell energy metabolism, barrier repair and the like, and the overall skin improvement effect is not obvious. The ergothioneine is used as a natural antioxidant, and the content of the ergothioneine is 0.01-5wt%; the ergothioneine participates in a synergistic effect of an intracellular antioxidant enzyme system, so that tyrosinase activity is effectively inhibited, melanogenesis is reduced, and DNA and protein are protected from oxidation damage; in a simulated strong ultraviolet environment, compared with skin cells not using the ergothioneine-containing product, the content of free radicals in the cells is reduced by 30% after the ergothioneine-containing product is used; the ergothioneine can also regulate a cell signal channel, promote cell metabolism and maintain normal growth of cells. The mask has the advantages of accelerating skin metabolism and improving the self-repairing ability of the skin.

The invention relates to an anti-aging oligopeptide for beauty and skin care, the oligopeptide has an amino acid sequence as shown in (X1) (R or K or H) G (D or E) # (X2), X1 represents one amino acid of G, A, V, L, I and P or represents that no amino acid exists, # represents one amino acid selected from A, V, D, E, N and Q, and X2 represents G and P or represents that no amino acid exists. The oligopeptide is a functional fragment of XVII type collagen, can induce in-vivo collagen synthesis or simulate a protein regulation function, has the effects of promoting cell self-cleaning, helping to remove aged skin cells, reconstructing skin rhythm, maintaining a good skin structure, resisting initial aging, promoting skin repair and regeneration, reducing fine wrinkles and the like, and is mild in action, free of side effects and free of toxic and side effects. The product has no obvious adverse reaction on human body, and is a good beautifying and anti-aging product.

The invention discloses a recombinant XVII type collagen engineering bacterium as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering, and the recombinant XVII type collagen engineering bacterium is realized through three steps of designing and optimizing collagen, improving translation through codon optimization and selecting a vector for cloning. By optimizing the amino acid sequence and the codon, the expression efficiency and the stability of the recombinant XVII type collagen in engineering bacteria are improved. The optimization not only improves the production efficiency of the protein, but also reduces the production cost. The recombinant XVII type collagen has potential in the medical field, especially in the fields of skin repair, wound healing, aging resistance and the like. Meanwhile, in the fields of beauty and biological materials, collagen is widely applied to products such as masks and skin care products as a basic component, and can promote skin cell regeneration and enhance skin elasticity and repair capacity.

The present invention belongs to the field of cosmetics detection, and discloses a method for evaluating the sun protection function of cosmetics and cosmetic raw materials and its application. This evaluation method uses a non-contact drug delivery device to test the sun protection effect of the test samples, and the test samples are finished cosmetics or diluted cosmetic raw materials; the tests include evaluating the in vitro sun protection efficacy by skin cells, evaluating the in vivo sun protection efficacy by the zebrafish embryo model, and result evaluation. This method evaluates the anti-aging effect of sun protection through the expression of β-galactosidase and / or the secretion of collagen in human dermal fibroblasts, and evaluates the sunburn prevention effect through the survival rate of human keratinocytes, DNA damage, or the secretion of inflammatory factors and the lethal / teratogenic conditions of zebrafish embryos, realizing multi-level and all-round evaluation of the sun protection efficacy. The method provided by the present invention is applicable to the evaluation of the sun protection function of various sun protection products, has accuracy and practicability, and provides an important technical basis for the research and development, quality control, and performance optimization of sun protection cosmetics.

The invention relates to an aloe extract nano-vesicle as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The aloe extract nano-vesicle provided by the invention is a nano-micelle formed by an aloe extract and tocopheryl acetate, the particle size of the aloe extract nano-vesicle is 280 to 500 nm, the Zeta potential of the aloe extract nano-vesicle is-10.12 to-11.34 mV, and the polydispersity coefficient of the aloe extract nano-vesicle is 0.239 to 0.434. The aloe extract nano-vesicle disclosed by the invention has a nano-scale size, and can easily penetrate through a skin barrier and enter skin cells, so that the moisturizing effect of the aloe extract nano-vesicle is achieved. The permeability of the moisturizing composition is far better than that of the traditional moisturizing composition, so that the required moisture can be more effectively provided for the skin. The aloe extract nano-vesicle can carry other active ingredients such as moisturizing factors to deeply permeate into skin, comprehensive care is provided for the skin, the texture and appearance of the skin are improved, the preparation process is simple, and the aloe extract nano-vesicle is suitable for technological production.

The invention discloses a plant lactobacillus capable of metabolizing dendrobium officinale components to generate various active small molecules and enhancing collagen synthesis promotion of skin cells, and belongs to the technical field of microorganisms. The lactobacillus plantarum (Lactobacillus plantarum) CCFM1496 obtained by screening can be used for fermenting the dendrobium officinale to generate a plurality of active substances and regulating and controlling the synthesis of skin collagen factors, and LOR (Lyclin) shows that the fermentation liquor of the dendrobium officinale fermented by the lactobacillus plantarum (Lactobacillus plantarum) CCFM1496 has a huge application prospect in the preparation of products for preventing or treating skin quality.

A biosynthesis method for preparing royal jelly acid and the use thereof in skin care, which belong to the technical field of genetic engineering and biosynthesis. The royal jelly acid is produced by means of fermentation on the basis of yeast engineering bacteria using a culture medium containing trans-2-decenoic acid. An assessment at both skin cell level and skin model level shows that royal jelly acid can promote the synthesis of stratum corneum lipids and ceramide on aging skin and repair the skin barrier; and also can promote the synthesis of mitochondria ATP and NADPH in skin fibroblasts, reduce the active oxygen content of mitochondria, improve mitochondrial dysfunctions, and inhibit apoptosis. Further experiments show that royal jelly acid can repair DNA damage of fibroblasts caused by ultraviolet irradiation, reduce telomere shortening caused by cell division and replication, and strengthen the protection of chromosomal terminal regions. The prepared royal jelly acid has wide application prospects in the development of functional skin care products for skin repairing, aging resisting, etc.

The invention relates to a skin grafting material and a using method thereof. The skin grafting material is composed of compressed sponge and repairing liquid. The compressed sponge is selected from chitosan sponge, collagen sponge or polyvinyl formal sponge; the repairing liquid is selected from normal saline containing human epidermal growth factors and / or normal saline containing superoxide dismutase. The use method comprises the following steps: attaching the skin layer of the cut skin graft to the compressed sponge, then putting the compressed sponge into a medical skin rolling machine, and cutting the skin graft into micro skin graft; the cut miniature skin graft is soaked in the repairing liquid, is attached to the position to be subjected to skin grafting after fully absorbing the liquid and expanding, and is wrapped with gauze. The skin grafting material provided by the invention can reduce damage to newborn granulation when the skin grafting material is removed, has an antibacterial effect and improves scar hyperplasia contracture after a skin grafting wound operation; meanwhile, the sponge which absorbs the liquid and expands can slowly release the repairing liquid, so that skin cell regeneration is promoted, epithelization of a skin grafting area is accelerated, and wound healing is promoted; the healing effect is good, and the application prospect is wide.

The invention discloses an acne-removing essence and a preparation method thereof, and particularly relates to the technical field of skin care products, the acne-removing essence comprises the following components by mass: 0.5-5% of salicylic acid; 1%-5% of tartaric acid; 2%-6% of nicotinamide; 0.5%-2% of colloidal sulfur; 1.5%-3% of tea tree essential oil; 1%-2% of hyaluronic acid; 0.5%-1% of ceramide; 1%-3% of glycerol; 1%-2% of trehalose; the salicylic acid is used for penetrating into skin, helping to relieve dead skin cells, reducing inflammation and accelerating skin renewal; the tartaric acid is used for realizing a stripping effect, can remove aged cuticles on the surface of the skin and promote the generation of new cells, so that the problem of acnes is helped to be improved. The acne-removing essence prepared by the invention has a relatively good moisturizing effect, so that skin barrier can be well maintained, keratin metabolism is promoted, grease secretion is inhibited, acne is effectively prevented, inflammatory response of the acne is relieved, and the actual use effect of the acne-removing essence is relatively good.

The present specification relates to a composition for skin protection, which comprises, as an active ingredient, thymol 3, 4, 5-trimethoxycinnamate (3, 4, 5-Trimethoxycinnate Thymol Ester), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition according to the present disclosure improves the expression of a DNA repair-related gene in skin cells that are photo-aged by ultraviolet light, thereby being capable of inhibiting or preventing skin damage caused by ultraviolet light or external environment or oxidative stress.

The invention relates to the technical field of nano-liposomes, and discloses cardamonin nano-liposomes for promoting transdermal absorption and a preparation method and application thereof, the cardamonin nano-liposomes comprise an inner phase and an outer phase, the inner phase comprises the following raw materials in parts by weight: 5-10 parts of cardamonin, 2-10 parts of lecithin and 5-20 parts of grease, and the outer phase comprises the following raw materials in parts by weight: 5-10 parts of cardamonin, 2-10 parts of lecithin and 5-20 parts of grease; the stabilizer is carboxymethyl chitosan; an external phase: 0.1-5 parts of a surfactant, 0.1-3 parts of a stabilizer, 10-20 parts of short-chain alcohol and 44.9-80 parts of water; the mixture of the external phase and the internal phase is sequentially subjected to homogenization treatment and microjet homogenization treatment, and the cardamonin nano-liposome for promoting transdermal absorption is prepared. The cardamonin nano-liposome for promoting transdermal absorption provided by the invention is a flexible liposome, and can moisten skin and reduce moisture loss on the skin surface; the transdermal amount and retention amount of the carried components are obviously improved; the permeability of the cardamonin to the skin cell membrane is enhanced.

The invention relates to the technical field of biology, in particular to an IL22 mutant as well as a preparation method and application thereof. According to the invention, IL-22 is mutated, and the mutation site is modified with PEG, so that the obtained mutant has good STAT3 / STAT1 preference, the STAT1 signal activation is significantly reduced, and the proinflammatory effect is significantly reduced. In addition, the compound can preferentially act on target organs of intestinal tracts in vivo, and does not easily activate skin cells to generate adverse reactions.

The invention discloses an extracellular vesicle and a preparation method and application thereof, and belongs to the technical field of cosmetics, and the preparation method comprises the following steps: mixing rose and a PBS buffer solution, juicing, and filtering to obtain a filtrate; adding cellulase, xylanase and beta-glucanase into the filtrate, carrying out enzymolysis, and filtering to obtain an enzymatic hydrolysate; and centrifuging the enzymatic hydrolysate, filtering, resuspending and precipitating to obtain the rose extracellular vesicles. The rose extracellular vesicles can guarantee structural integrity and biological activity, can effectively load active ingredients, and can effectively deliver active molecules in the rose extracellular vesicles to target cells through interaction with membranes of skin cells. The extracellular vesicles can be fused with skin cell membranes to enter cells, active ingredients encapsulated by the extracellular vesicles are released, and the absorption efficiency of skin is improved.

The invention discloses an anti-aging composition and a preparation method thereof, and belongs to the technical field of cosmetics, the anti-aging composition provided by the invention is prepared from the following components in parts by mass: 0.001-0.01 part of freeze-dried powder of secretin of porcine umbilical cord mesenchymal stem cells, 15-20 parts of argania spinosa leaf extract, 10-13 parts of eucheuma gelatinae extract and 1-3 parts of northeast stichopus japonicus adventitious root extract. The anti-aging composition provided by the invention has the effects of resisting aging and improving the migration rate of skin cells, and the whole anti-aging composition is mild and non-irritant; when the anti-aging composition is applied to cosmetics, the anti-aging composition can effectively resist aging, lighten wrinkles, improve skin elasticity and increase the water content of cuticles. In addition, the composition provided by the invention is natural in component source, simple in preparation method and suitable for actual production.

The invention relates to an anti-ultraviolet-damage composition and application thereof in sunscreen products, and the anti-ultraviolet-damage composition is prepared from the following raw materials in parts by weight: 5-8 parts of oxhide tea leaf extract, 3-7 parts of green alga extract, 1-4 parts of dogwood extract, 8-10 parts of sea-buckthorn extract, 2.5-4 parts of butyrospermum parkii butter and 5-8 parts of camellia oleosa seed oil. All the raw materials have a synergistic effect, and free radicals generated by ultraviolet induction are neutralized, so that oxidative stress is relieved, and skin cells are protected from being damaged; ultraviolet rays are absorbed and are prevented from penetrating through the skin, so that direct damage of the ultraviolet rays to the skin is reduced; the activity of tyrosinase is regulated or a melanin synthesis pathway is blocked, the accumulation of melanin is reduced, and the effects of preventing and improving stains, darkness and the like are achieved.

The present invention relates to a functional cosmetic composition comprising plant exosomes derived from ginseng as an active ingredient and a functional cosmetic containing the same. Ginseng exosomes have a bilipid layer structure and are rich in ginsenosides Rb1 and Rg1, which influence skin improvement and whitening. It has been proven that these powerful functional materials, ginsenosides Rb1 and Rg1, are absorbed in large quantities through ginseng exosomes into skin cells, enhance the synthesis of collagen and hyaluronic acid in skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosomes rich in ginsenosides Rb1 and Rg1, presented in the present invention, can be beneficially used in functional cosmetic compositions for skin aging prevention, skin whitening, wrinkle improvement and skin cell regeneration.

The invention discloses a thermal spring water composition for relieving itching and soothing skin and a preparation method of the thermal spring water composition, and belongs to the technical field of itching relieving and soothing. Chitosan has good film-forming property, after chitosan, mung bean protein and the like form a compound, after the compound is smeared on the surface of skin, a layer of relatively stable protective film with certain air permeability can be constructed, skin allergy and inflammatory reaction can be reduced, a relatively wet microenvironment is formed on the surface of the skin, and the skin care effect is improved. The moisture loss of the skin is reduced, and the moisture balance of the skin is favorably kept, so that uncomfortable symptoms such as dry and tight skin are relieved, and the skin is further promoted to be relieved; after the centella asiatica polysaccharide is subjected to carboxymethylation modification, the water solubility and the biological activity of the centella asiatica polysaccharide are remarkably improved, and the carboxymethylated centella asiatica polysaccharide and the mung bean protein-chitosan compound have a synergistic effect, so that the barrier function of skin can be enhanced, the metabolism of skin cells can be regulated, and the skin can be effectively protected. The repair and regeneration of damaged skin cells are promoted.

The invention relates to a water-in-oil nanoemulsion with high drug loading capacity as well as a preparation method and application of the water-in-oil nanoemulsion. The water-in-oil nanoemulsion is prepared by dropwise adding a water-phase solution containing tocoxolam into an oil-phase solution, the water-phase solution is prepared from tocopherol, a cosurfactant, a hydrophilic active matter, a preservative and water; the oil phase solution is composed of liquid grease and a surfactant; the water-in-oil nanoemulsion is prepared from the following components in percentage by mass: 50 to 64 percent of liquid grease, 10 to 17 percent of surfactant, 5 to 8 percent of tocoxolam, 5 to 12 percent of surfactant, 0.1 to 6 percent of hydrophilic active matter, 0.2 to 0.6 percent of preservative and 8 to 15 percent of water. The water-in-oil nanoemulsion has the advantages of high drug loading capacity, good skin permeability, high retention volume in skin cells, high bioavailability, good stability, high safety and the like, and can be used in pure oil cosmetics.

The present invention relates to a functional cosmetic composition comprising plant exosome derived from ginseng as an active ingredient thereof and a functional cosmetic comprising the same. Ginseng efflux has a dual lipid layer structure and is rich in ginsenosides Rb1 and Rg1 that affect skin improvement and whitening. The powerful functional substances ginsenosides Rb1 and Rg1 have been proved to be massively absorbed into skin cells through ginseng exosomes, enhance the synthesis of collagen and hyaluronic acid in the skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosome rich in ginsenosides Rb1 and Rg1, as presented in the present invention, can be advantageously used in a functional cosmetic composition for skin aging prevention, skin whitening, wrinkle reduction, and skin cell regeneration.

The invention relates to the field of daily cosmetics, health care product raw materials and biology, and discloses lactobacillus rhamnosus JMB235 with the preservation number of CCTCC (China Center for Type Culture Collection) No.M 20232530. The fermentation product of lactobacillus rhamnosus has multiple effects, and can control grease secretion, prevent alopecia, inhibit acne, promote hair growth, inhibit eczema, inhibit inflammation, maintain skin barrier, promote epidermal cell proliferation and differentiation, block sun, repair damaged skin or improve insomnia. The compound can be used for preparing skin external preparations, health-care products, beautifying oral preparations, foods or food additives. And the fermentation product has good stability, is storable and has a wide application prospect.

The invention relates to an anti-aging composition for promoting skin intercellular communication and application thereof, and the composition comprises the following components: a camellia nitidissima flower extract, a bacillus fermentation product, an European basswood extract and safflower glucoside, the weight ratio of the golden camellia flower extract to the bacillus fermentation product to the European basswood extract to the safflower glucoside is (1-10): (1-8): (1-6): (0.1-1). The anti-aging composition provided by the invention can promote the activity of skin communication cells, enhance intercellular communication and interaction, give full play to the biological function of cells, and achieve the anti-aging effect; the composition has the effects of removing wrinkles, tightening, smoothing and repairing, can inhibit damage of cortisol to skin barriers, achieves the effects of repairing and relieving mood pressure, and can achieve the optimal effects of removing wrinkles, tightening, smoothing and repairing due to mutual synergism of the components.

The invention discloses a double-chain miRNA, a pharmaceutical composition containing the same, an anti-aging product and application of the double-chain miRNA. The double-stranded miRNA comprises a chemically modified sense strand with a sequence shown as SEQ ID NO: 1 and a chemically modified antisense strand with a sequence shown as SEQ ID NO: 2, wherein the chemical modification of the sense strand and the antisense strand each comprises a 2 '-substituted nucleotide and a modified nucleotide bond; the chemically modified nucleotide bond is at least located at one or more of the 1st-3rd and 20th-23rd sites of the sequence shown as SEQ ID NO: 1 and / or SEQ ID NO: 2. The double-chain miRNA is good in stability and has a remarkable treatment effect on skin cell photoaging, Alzheimer's disease, articular cartilage injury, diabetes, non-alcoholic fatty liver disease, androgenetic alopecia, cirrhosis and chronic nephritis. In short, the effect and the stability of the product are both considered, and the application prospect is good.

A whitening composition comprising a bilayer vesicular inclusion with a skin cell membrane-like structure formed by a phospholipid, a polyol, a co-emulsifier, and a liquid oil, wherein the phospholipid serves as a main wall material of the inclusion, and an alcohol-soluble main ingredient, an auxiliary ingredient, an antioxidant ingredient, and an anti-inflammatory ingredient in an aqueous plant extract solution are encapsulated in the inclusion, with a signal molecule attached to the surface of the inclusion. The whitening composition inclusion solution of the present application has good whitening efficacy due to the synergistic effect among various components.

The invention discloses a stem cell composition for promoting skin cell repair and a preparation method and application thereof, and belongs to the technical field of skin repair. The stem cell composition for promoting skin cell repair is prepared by mixing the skin repair peptide separated from cultured giant salamanders with umbilical cord mesenchymal stem cell supernate for the first time. The skin repair peptide and the umbilical cord mesenchymal stem cell supernate in the composition have a synergistic effect, and the skin repair peptide and the umbilical cord mesenchymal stem cell supernate are combined to effectively improve fibroblast proliferation and promote secretion of type I and type III collagen, so that skin injury repair is facilitated, and the composition has a good commercial application prospect.

The application provides a thermoelectric hydrogel composite dressing for promoting repair of diabetic ulcers and loading of targeted modified exosomes and a preparation method, which comprises the following steps: preparing methacrylated hyaluronic acid; preparing polyether F127 diacrylate; co-incubating exosomes with palmitic acid grafted targeting peptides to prepare targeted modified exosomes; mixing the methacrylated hyaluronic acid, the polyether F127 diacrylate, a photosensitizer, the targeted modified exosomes and an electrolyte, and crosslinking under ultraviolet light to form a composite gel. The composite dressing is a novel composite dressing for thermoelectric stimulation and exosome treatment. On one hand, the dressing generates a wireless and passive electric field to simulate the endogenous electric field in the wound, promote directional migration of skin cells, accelerate reepithelialization and dermal formation; on the other hand, the dressing releases exosomes to precisely target blood vessels of a wound lesion, reverse endothelial dysfunction in a high-sugar environment and promote angiogenesis, and effectively solves the problems in repair and regeneration of diabetic ulcer wounds.

The invention discloses a PDRN nano-liposome preparation method, which comprises: S1, taking hydrogenated lecithin, polyglycerol-10 myristate, stearoyl glutamate and glycerin, heating, and uniformly mixing to obtain an oil phase liquid; s2, adding macromolecular PDRN, micromolecular PDRN and hydrolyzed sodium hyaluronate into water, heating and uniformly mixing to obtain a water-phase liquid; s3, adding the water-phase liquid into the oil-phase liquid in a stirring state, and continuously stirring to obtain crude lipidosome; s4, carrying out microjet treatment on the crude liposome under the pressure of less than or equal to 1000bar to obtain the PDRN nano-liposome; wherein the step S1 and the step S2 do not have sequence requirements. The invention also provides the prepared PDRN nano-liposome. The invention further provides the PDRN nano-liposome. The PDRN nano-liposome provided by the invention is high in stability, can rapidly permeate, synergistically enhances the skin cell repairing and anti-aging effects, and is simple in preparation process.

The invention discloses a poly-deoxyribonucleotide salt and a preparation method and application thereof, the content of the poly-deoxyribonucleotide salt is greater than 95%, the protein content is less than 1.0%, and after high-pressure moist heat sterilization, the dynamic viscosity reduction amount does not exceed 25%, and the elastic index G'reduction amount does not exceed 30%. The polydeoxyribonucleotide salt disclosed by the invention is simple in preparation process, short in production period, low in cost and suitable for large-scale industrial production; and the preparation process is mild, few impurities are introduced, the product structure is less damaged, and the preparation method is environment-friendly. The polydeoxyribonucleotide salt disclosed by the invention has good physical support performance, has the effects of promoting skin cell repair, resisting skin sensitivity, whitening, resisting inflammation, preventing alopecia and growing hair, and has a wide market prospect.

The invention relates to a micromolecule RNA (Ribonucleic Acid) composition and an application thereof in preparing a skin beautifying and repairing product. Comprising tiRNA-1: 34-Glu-CTC-1-M2 and tRF-1: 30-Glu-CTC-1-M2, and the nucleotide sequences of the tiRNA-1: 34-Glu-CTC-1-M2 and the tRF-1: 30-Glu-CTC-1-M2 are as shown in SEQ ID The invention further provides application of the small molecule RNA composition in preparation of skin beautifying and repairing products. It is found for the first time that the composition of tiRNA-1: 34-Glu-CTC-1-M2 and tRF-1: 30-Glu-CTC-1-M2 can promote proliferation and migration of human skin cells, collagen synthesis and secretion in the human skin cells and expression of genes related to angiogenesis are improved, and meanwhile aging of the human skin cells is delayed. Besides, the small molecule nucleic acid RNA composition reduces expression of inflammation-related factors so as to exert an anti-inflammatory effect, exerts the effects of promoting skin regeneration and repair, improving skin aging, resisting inflammation, promoting skin collagen and blood vessel regeneration and the like, can be used for preparing skin beautifying and repairing products, provides a new method and a new thought for the field of skin beauty treatment, and has wide application prospects. Good commercial application prospects are realized.