The invention provides a sunscreen mist spray which comprises the following raw materials: methoxy-cinnamic acid ethylhexyl acrylate, octocrilene, bi-ethyl hexyloxyphenol methoxyphenyl triazine, butylmethoxy-dibenzoyl methane, natural phospholipid, absolute ethyl alcohol, titanium dioxide, zinc oxide, polydimethylsiloxane, polydimethylsiloxane, an emulsifier, 1,2-pentanediol, disodium hydrogen phosphate, sodium alginate, mannitol, sodium hyaluronate and water. A preparation method comprises the following steps: firstly, preparing lipidosome from chemical sunscreen agents, and together with physical sunscreen agents, preparing the sunscreen mist spray. By adopting the sunscreen mist spray, on one hand, irritation of the chemical sunscreen agents to skin can be reduced, on the other hand, the sunscreen agents can be uniformly clung to the surface of skin, the action time of the chemical sunscreen agents is prolonged, the overall sunscreen effect of the mist spray is greatly improved, and the use amount of the mist spray can be reduced.