The invention relates to a production method of a negative oxygen ion multifunctional automotive trim leather. The production method comprises fleshing, liming, deliming, softening, pickling, tanning, retanning, neutralization, dyeing, fat liquoring, drying, softening, bottom coating, middle coating, knurling and top coating; in the pickling and tanning steps, salt is added for pickling, and aldehyde is added for tanning; the pickling by adding the salt is as follows: the leather is washed by softening water; the liquid ratio is 50%; by 100 mass parts of the leather, 50 parts of water are added; the temperature is controlled at 20+-2 DEG C; 7 parts of sodium chloride are added for reaction by 15 minutes; then, 0.5 part of 10 wt% of dilute formic acid is added for reaction by 30 minutes; then, 0.5 part of 10 wt% of dilute formic acid is added for reaction by 30 minutes; 0.35 part of 5 wt% of dilute sulfuric acid is added for reaction by 30 minutes; sulfuric acid is added again by the same mode for reaction by 90 minutes; after dilute sulfuric acid is added, the pH value is controlled within 2.8+-0.1; and the reaction is performed by 60 minutes. The production method has the functions of constant release of negative oxygen ions, sterilization and bacteria resistance, achieves the effect of efficiently absorbing, decomposing and degrading such harmful gas as formaldehyde, and achieves softness and excellent shaping property.