2349 results about "Blisters" patented technology

Stable solutions of lipophilic drugs, such as cyclosporin, forming a polar lipid self-emulsifying drug delivery system. The solutions can include lipophilic drugs, such as cyclosporin, dissolved in a polar lipid, such as having a C₆-C₁₂ fatty acid monoglyceride content of at least about 50%, surfactants and triglycerides. The composition forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.

Devices and methods for the treatment of skin conditions and lesions are disclosed herein. A compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices employ the application of ultrasound energy and heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 40° C. to about 70° C. by the devices, are achieved in less than about 20 second, and maintained for less than about 40 second. Ultrasound absorption and thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.

The present invention includes dry powder inhalers and associated multi-dose dry powder packages for holding inhalant formulated dry powder substances and associated fabrication and dispensing methods. The multi-dose package can include a platform body comprising at least one thin piezoelectric polymer material layer defining at least a portion of a plurality of spatially separated discrete elongate dry powder channels having an associated length, width and height; and a metallic material attached to selected portions of the piezoelectric polymer material including each of the regions corresponding to the elongate dry powder channels to, in operation, define active energy releasing vibratory channels. In operation, the elongate channels can be selectively individually activated to vibrate upon exposure to an electrical input.

The dry powder inhaler includes an elongate body having opposing first and second outer primary surfaces with a cavity therebetween and having opposing top and bottom end portions and a multi-dose sealed blister package holding a plurality of discrete meted doses of a dry powder inhalable product located in the cavity of the elongate body. The inhaler also includes an inhalation port formed in the bottom end portion of the elongate body, the inhalation port configured to be in fluid communication with at least one of the discrete meted doses during use and a cover member that is pivotably attached to the elongate body so that it remains attached to the body during normal operational periods of use and moves to a first closed position to overlie the inhalation port at the bottom end portion of the body during periods of non-use and moves to a second open position away from the inhalation port during periods of use to allow a user to access the inhalation port.

A system for managing delivery of pharmaceutical drugs is formed of a blister package that includes a plurality of cells arranged in a grid. Each of the cells is sealed by a breakable wall and holds a unit-dose of medication. A user gains access to the medication in a given cell by puncturing the breakable wall associated with the given cell. A severable conductor is positioned proximate to each breakable wall. The severable conductor associated with a given cell ruptures upon puncturing of the breakable wall associated with the given cell. A computer chip is electrically connected to the severable conductors. The computer chip senses the puncturing of each cell in the grid by monitoring the rupturing of each of the severable conductors. An RF transmitter is coupled to the computer chip. The RF transmitter sends information corresponding to usage of each of medications stored in the blister package to a remote information transceiver.

The invention provides minimally invasive microsurgical tools and methods to form an aqueous humor shunt or bypass for the treatment of glaucoma. The invention enables surgical creation of a tissue tract (7) within the tissues of the eye to directly connect a source of aqueous humor such as the anterior chamber (1), to an ocular vein (4). The tissue tract (7) from the vein (4) may be connected to any source of aqueous humor, including the anterior chamber (1), an aqueous collector channel, Schlemm's canal (2), or a drainage bleb. Since the aqueous humor passes directly into the venous system, the normal drainage process for aqueous humor is restored. Furthermore, the invention discloses devices and materials that can be implanted in the tissue tract to maintain the tissue space and fluid flow.

Methods and structures are disclosed for advanced interconnects in sub-micron and sub-half-micron integrated circuit devices fabricated using a single damascene process. a dielectric etch-stop layer (e.g., silicon nitride) is deposited subsequent to rather than prior to CMP processing of the previous metallization layer (e.g., the conductive plug). This scheme effectively eliminates the effect of CMP-induced erosion on the etch-stop layer and therefore allows an extremely thin etch stop to be used. Moreover, a high etch-selectivity can be obtained for the trench etch, and all etch-stop material is removed from beneath the interconnect metal, thereby reducing parasitic effects. A patterned dielectric layer is used as a metal cap in place of the standard blanket silicon nitride layer, thus preventing the formation of blisters and bubbles associated with trapped moisture and gasses, and reducing interconnect capacitance.

Packaging systems for medical devices, such as surgical instruments, implants, and prostheses, are provided herein. In one embodiment, the packaging system comprises a blister tray that is at least semi-transparent and has at least one cavity capable of containing a medical device or portion thereof. The system additionally comprises a card having at least one window, wherein the at least one cavity in the blister tray protrudes through the at least one window in the card. The packaging systems provide a convenient, informative, and preferably sterile means of distributing medical devices.

A device having a plurality of cassettes, each filed with a supply of pills and positionable over a target location. The device has a platen beneath the target location with receptacles configured to hold both vials and blister packs. The platen or the cassette is movable so that any blister of the blister pack or the vial can be positioned under the target location to receive a quantity of pills from a cassette.

A reclosable package and method having an integral reclosable door adjacent one end that permits article removal from the end of the package. The package is comprised of a thermoformed blister body joined to a thermoformed backing body. The blister body has sidewalls, endwalls and a peripheral flange broken into a first section adjacent the door where the height of the sidewalls decrease and a second section opposite the door with the first section angled relative to the second section. The backing body carries the door and has an integral peripheral rib inboard of a peripheral flange with the flange having a first section about the door and a second section disposed away from the door. The rib has a pair of longitudinally-extending sections divided by a notch that preferably is a transverse rib that causes the door to bend about a desired fold line that runs generally through or adjacent the ribs or notches when urged away from a closed position. In a preferred method, after performing a multilevel trim operation to trim the multiplanar flanges of one or both the blister body and the backing body, the two bodies are joined at the flange sections about a portion of the periphery to adjacent the fold line using an energy welding process, preferably RF welding, that produces a narrow tear seam that enables finished package flange width to be minimized to thereby also minimize package width.

A system is provided for monitoring the removal of blister pack contents. An array of spatially-extended, electrically parallel breakable traces made from electrically resistive material is formed behind a corresponding array of blisters of a blister card. Then this array is connected in series with a reference resistor to form a voltage divider. All resistive traces are formed from the same materials in a single operation. Blister breakage is determined using changes in the ratio of the resistances of the array and the divider. A predictive algorithm is used to adjust the threshold resistance ratio change that signals blister breakage and voltage ratios are used to adjust for battery output changes over time. Breakage events and their time of occurrence are recorded in nonvolatile memory for later retrieval. Additional resistors can be used for activating the system and detecting tampering.

A dry powder inhaler has a vibrator coupled to a blister filled with a dry powder drug substance. One or more of drug ejection apertures in the blister are substantially opposite the vibrator. One or more air intake apertures in the blister are not opposite the vibrator. Upon vibration of the vibrator, the drug substance is deaggregated, aerosolized, and ejected from the drug ejection apertures for inhalation by a patient.

The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.

A drug delivery device that aerosolizes a dry powder formulation so that it forms a fine coating in the oral cavity and, more specifically, in the sublingual region of the oral cavity is described herein. In the preferred embodiment, the device contains five main parts: (i) a compressed gas canister, (ii) a dispenser body (also referred to herein as the main housing), (iii) a means for storing one or more doses of a drug formulation, (iv) a means for releasing a dose of the drug formulation such as a gas canister or spring piston and (v) a mouthpiece. Preferred configurations include circular, tubular, and rectangular. The means for storing the drug formulation may be configured to separately store one or more materials. In one embodiment, the means for storing the active agent is in the form of one or more drug discs, where the drug discs contain a plurality of blister packs, each storing one dose of the drug formulation. In another embodiment, the means for storing the active agent is a dosage cartridge containing a single dose of the drug formulation. In yet another embodiment, the drug formulation is stored on a ribbon containing a plurality of blister packs, each storing one dose of the drug formulation.

Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.

A pneumatic tire is provided which includes an outer circumferential rubber tread and a supporting carcass. A rubber inner liner is disposed inwardly from the supporting carcass. A built-in sealant layer is situated adjacent to an innermost removable barrier layer and disposed inwardly from the rubber inner liner. The built-in sealant layer provides self-sealing properties to the pneumatic tire. The pneumatic tire, with its innermost removable barrier layer, keeps the sealant layer from sticking to a tire-building apparatus during tire assembly and, after curing of the assembled tire, is eventually removed to permit gas from the built-in sealant layer to become part of the tire's inflation air to prevent or reduce instances of inner liner blister formation.

Various RFID based blister pack embodiments are provided for improving the ability to detect and prevent tampering and counterfeiting of blister packs and/or facilitating the chain of custody tracking of blister packs during manufacture. Some embodiments employ an RFID chip network on the blister pack and some embodiments employ an RFID strap network on the blister pack, wherein the integrity of the network (or lack thereof) is used to indicate the possibility of tampering. Other embodiments determine the possibility of tampering based on the frequency of an RF signal that is received from a chip provided on the blister pack, which will vary depending on whether the associated antenna has been detuned as a result of some type of tampering.