98 results about "Powder Inhaler" patented technology

The present invention relates to a pharmaceutical composition in inhalable pre-metered dry powder form that comprises at least one excipient (for example carrier) and at least one active substance used against viral diseases to locally administer it to the lungs for use in the treatment of symptoms of viral lung diseases including COVID-19 caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-COV-2) by means of dry powder inhaler through inhalation. The present invention also relates to methods for preparation of said pharmaceutical composition and the use of these active substances in symptoms caused by COVID-19. similar viral lung diseases, influenza.

Provided are a rotating mechanism (2), a dosage protection mechanism (3), a breath triggering apparatus (100), and a dry powder inhaler (800). The rotating mechanism (2) is applied to the breath triggering apparatus (100), and the rotating mechanism (2) comprises: a rotating shaft (22), an outer side surface of which is provided with a notch (221); and a baffle (21) connected to the outer side surface of the rotating shaft (22), wherein the rotating mechanism (2) is rotatable between a first position and a second position, and when in the first position, blocks a first airflow channel of the breath triggering apparatus (100); when moving from the first position to the second position, the baffle (21) rotates around the rotating shaft (22) to open the first airflow channel. By means of the above configuration, the problem of inadequate drug powder deaggregation in the prior art can be effectively resolved.

The invention provides a powder inhaler. The powder inhaler comprises a shell assembly; the depolymerization mechanism is provided with a depolymerization cavity; the powder delivery mechanism is arranged in the shell assembly and provided with a plurality of capsule cavities, and the capsule cavities are used for storing powder capsules; the powder delivery mechanism can move relative to the depolymerization cavity, so that the plurality of capsule cavities are sequentially communicated with the depolymerization cavity; one of the shell assembly and the powder delivery mechanism is provided with a first limiting piece, and the other one of the shell assembly and the powder delivery mechanism is provided with a plurality of second limiting pieces; and when the capsule cavity is aligned with the depolymerization cavity, the first limiting piece is clamped with one second limiting piece. The powder inhaler can provide multiple doses of powder capsules; and moreover, the capsule cavity and the depolymerization cavity can be prevented from being misplaced, so that the proportional distribution of air inflow and the suction resistance and depolymerization effect are not influenced.

The present invention relates to an ambroxol-ibuprofen cocrystal dry powder inhaler, a preparation method and application thereof, and belongs to the professional field of pharmaceutical preparations. The dry powder inhaler is mainly composed of ambroxol, ibuprofen and lactose, the molar ratio of ambroxol to ibuprofen is 1:1, and the mass ratio of lactose to ambroxol-ibuprofen cocrystal is 5-35%. The results of the rat lung tissue distribution experiment showed that the administration method of dry powder inhalation can significantly enhance the drug delivery efficiency in the lungs and greatly prolong the drug retention time in the lungs compared with the traditional intravenous administration. Pharmacodynamic experiments further revealed that the ambroxol-ibuprofen cocrystal dry powder inhaler can effectively inhibit the active expression of inflammatory factors in model animals, and reduce the accumulation of hydroxyproline (HYP) in lung tissue and serum, improve anti-fibrosis and anti-inflammatory capabilities, improve oxidative stress capabilities, thereby helping to delay the pathological process of pulmonary fibrosis, showing great development potential as an anti-pulmonary fibrosis drug.

1. Name of the Design Product: Integrated Medication Recorder (Dry Powder Inhaler). 2. Use of the Design Product: To record medication usage. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Combined State Diagram.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The present invention relates to a device (20) for delivering a medicament (30) to a user via the nasal or pulmonary route. The device may be a pressurized metered dose inhaler (200), an active dry powder inhaler (300 / 400), a soft mist inhaler (500), or a nebulizer (600). The device (20) comprises a propellant energy source (40) for delivering the medicament (30), the propellant energy source (40) being or comprising an atmospheric gas (41) stored in a canister (45) separate from the medicament, adsorbed on an adsorbate (42) at a pressure of at least 2 bar, the atmospheric gas being released from the canister to dispense the medicament (30). The device includes a gas delivery mechanism (50) having a metering chamber (52) that has a greater capacity than a conventional pressurized metered dose inhaler filled with HFC propellant. The atmospheric-like gas (41), upon actuation, is released from the chamber and travels along the conduit (25) to displace a dose of medicament (30) from the dose chamber (80) undergoing aerosolization and exit the device as a plume (60) via a second conduit (27) and an outlet (28).

The utility model relates to the technical field of dry powder flow velocity monitoring, and discloses a flow velocity monitoring device of a dry powder inhaler, which comprises a dry powder storage tank, a suction nozzle is arranged on the outer wall of the dry powder storage tank, a suction channel is fixedly connected inside the dry powder storage tank, and a partition plate is fixedly connected to the outer wall of the suction channel. A gear ring is rotatably connected to the outer wall of the partition plate, a rotating handle is fixedly connected to the outer wall of the gear ring, a transmission gear is connected to the inner wall of the gear ring in a meshed mode, a rack is connected to the outer wall of the transmission gear in a meshed mode, and a closing plate is fixedly connected to the outer wall of the rack. According to the utility model, the rotating handle is pushed to drive the gear ring to rotate, then the transmission gear slides along with the rotation of the gear ring, and finally the flow rate port is opened and closed by the closing plate to adjust the size, so that the effects of adapting to the inspiration ability of different patients and improving the treatment accuracy can be achieved.

A powder inhaler assembly comprises a powder inhaler (2) comprising a metering device (10) having a dosing recess (11) and being movable, with respect to a container (8) and an inhalation channel (9), between an inactive state, in which the dosing recess (11) is in communication with an opening (12) of the container (8) to be filled with a dose of the powdered drug, and an active state, in which the dosing recess (11) is in communication with the inhalation channel (9) to allow inhalation of a dose of the powdered drug contained in the dosing recess (11) through a mouthpiece (6). An electronic module (3) may be attached to the powder inhaler (2) and comprises a contactless sensor (29) positioned and configured to detect the position or positions of at least part of the metering device (10) to detect at least when the metering device (10) is in the active state.

The invention discloses a powder inhaler. The powder inhaler comprises a functional mechanism, a suction nozzle and an outer cover. The functional mechanism comprises a suction channel; the suction nozzle is communicated with the suction channel; the outer cover is in linkage fit with the functional mechanism and is limited to rotate back and forth between a first position and a second position; the outer cover is configured to shield the suction nozzle at the first position and not shield the suction nozzle at the second position. The stroke of the outer cover rotating from the first position to the second position comprises a cover opening idle stroke and a cover opening load stroke, the inner cover and the outer cover do not trigger the action of the functional mechanism in the cover opening idle stroke, and the inner cover and the outer cover trigger the functional mechanism to deliver powder to the suction channel in the cover opening load stroke; and / or, the stroke of resetting the outer cover from the second position to the first position comprises a cover closing idle stroke and a cover closing load stroke, the inner cover and the outer cover do not trigger the function mechanism to act in the cover closing idle stroke, and the inner cover and the outer cover trigger the function mechanism to reset in the cover closing load stroke. By means of the arrangement, good linkage among the mechanisms is achieved in the cover opening and closing process.

Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.

The invention relates to a powder inhaler comprising a body (10) accommodating a strip (20) of at least two individual reservoirs (20a, 20b, 20c, 20d), each individual reservoir having a cavity (21) containing a dose of powder and a closure layer (22) for sealing the cavity (21), the body (10) comprising a head portion (11) and a support portion (12), the head portion (11) and the support portion (12) being connected by at least one articulation (13) such that the body (10) is deformable and / or movable between an open position and a closed position, wherein the head portion (11) comprises a dispensing port (110) and a perforating element (112) connected to the dispensing port (110) and capable, during actuation, of piercing the closure layer (22) in order to open an individual reservoir (20a, 20b, 20c, 20d), and wherein the head portion (11) comprises at least one axial projection (115) associated with the perforating element (112), and wherein the strip (20) of reservoirs comprises at least one lateral edge provided with cut-outs (24a, 24b, 24c) arranged between the individual reservoirs (20a, 20b, 20c, 20d), which define flaps (25a, 25b, 25c, 25d) for each individual reservoir (20a, 20b, 20c, 20d), and wherein each axial projection (115) folds a respective flap (25a, 25b, 25c, 25d) during actuation.

A breath-actuated dry powder inhaler (301, 401, 501), said inhaler comprising: a substantially planar housing consisting of a stack of substantially planar elements, said planar elements comprising a bottom plate (319, 419, 519), an intermediate plate (318, 418, 518) and a top plate (317, 417), said planar elements being parallel to each other, at least one planar element being provided with a projection, said projection being arranged between the bottom plate (319, 419, 519) and the intermediate plate (318, 418, 518) and the top plate (317, 417); the protrusions form a substantially disc-shaped air circulation chamber (302) in the stacked structure for depolymerizing entrained powdered medicament using the energy of the suction air flow; a plurality of air supply channels (307); an air supply area for the powder flow; and a discharge channel (312) of the inhaler; the chamber has a generally polygonal side wall (303) extending between a top wall and a bottom wall of the chamber about a central axis extending transverse to the floor, the height of the chamber being less than the diameter of the chamber. The inhaler has a planar dose compartment (323, 423, 523) received in a slidable manner between two of the three plates.

Aerosolization devices and procedures are described that improve air-jet dry powder inhaler (DPI) technologies and other types of inhalers, thereby optimizing aerosolization performance and expanding dosing capacity. One example device includes a variable-sized aerosolization chamber and an adjustment mechanism that allows the chamber size to be changed between activations. During use, the distance between the aerosolization chamber's air channel and the top of the powder bed remains virtually constant, even as the powder bed empties with each successive activation of the device.

A dual-reservoir dry powder inhaler apparatus, belonging to the field of administration apparatuses. A first drug storage barrel (901) and a second drug storage barrel (902) are arranged. A first drug pit (1604) and a second drug pit (1603) are correspondingly arranged below the first drug storage barrel (901) and the second drug storage barrel (902), respectively. A first delivery channel and a second delivery channel are arranged. One end of the first delivery channel and one end of the second delivery channel correspond to the first drug pit (1604) and the second drug pit (1603), respectively, and the other end of the first delivery channel and the other end of the second delivery channel are connected to a dispersion cavity. Two drugs are separately stored in the first drug storage barrel (901) and the second drug storage barrel (902). A "rotary disc" type dose allocation structure is adopted, and the drugs are delivered to the same dispersion cavity by means of the separate drug pits and the separate delivery channels and then delivered to a drug outlet (101) by means of a suction nozzle channel. The processes of dispensing, allocating a single inhalation dose, and delivering to the dispersion cavity to be delivered to the drug outlet (101) for the drugs in the first drug storage barrel (901) and the second drug storage barrel (902) are simultaneously conducted, thereby ensuring that the drugs at two doses can be dispersed and delivered into the body of a patient simultaneously. It can be ensured that the two drugs do not interfere with each other in the storage and dose allocation processes. The dual-reservoir dry powder inhaler apparatus can be widely applied to the field of design and manufacture of dry powder inhaler apparatuses.

The application discloses a powder medicine suction nozzle, and the waxy rice paper group is installed on the piston rod through the clamping assembly; blood or oral fluid of a wound is adhered to the waxy rice paper on the waxy rice paper group, so that the medicine is adhered to the wound and is blocked between the wound and the waxy rice paper, thereby avoiding medicine spilling when taking medicine and avoiding the problem of waste caused by the medicine falling off because the medicine cannot be adhered to the wound in time. In the second embodiment, the multiple layers of plastic films and the multiple layers of waxy rice papers are alternately stacked, so that the problem of multiple layers of penetration caused by excessive blood or oral fluid after the waxy rice paper contacts the wound is avoided, and the U-shaped groove facilitates the operation of taking off the plastic film. In the third embodiment, the steel connecting rod and the strong magnetic adsorption are utilized to pull the clamping plate to be clamped on the U-shaped clamping extension piece, so that the stable clamping effect is achieved, and the installation and replacement of the later layer of plastic film are facilitated.

The present disclosure provides a method for manufacturing an inhaler article having an upstream resilient element (101) for insertion into a holder to form an inhaler system for providing a dry powder to the lungs of a user, the manufacturing method comprising: moving a ribbon (402) of resilient material from a feeder reel (401) to a cutting stage (405); presenting the ribbon of resilient material to the cutting stage; cutting at least one disk of resilient material from the ribbon of resilient material to form at least one cut disk of resilient material; presenting the at least one cut disk of resilient material to a glue stage (501); dispensing at least one glue ring (502); applying the at least one glue ring to the at least one cut disk of resilient material; and, presenting the at least one cut disk of resilient material having an applied glue ring to an upstream end (120) of an inhaler article; affixing the at least one cut disk of resilient material having an applied glue ring to the upstream end of an inhaler article to form an inhaler article having an affixed upstream resilient element.

The passive dry powder inhaler comprises a box body, the box body comprises a gas cylinder box and a capsule box located at the top of the gas cylinder box, a gas cylinder is arranged in the gas cylinder box, compressed gas is arranged in the gas cylinder, a capsule bin is arranged in the capsule box, the top of the capsule box is open and provided with a top cover, and the top cover is provided with a suction nozzle. The bottom end of the suction nozzle is provided with an air suction needle used for puncturing a capsule, the capsule box is slidably connected with at least one set of buttons, the same set of buttons comprises two non-coaxial and parallel buttons, the buttons are provided with air inlet needles capable of puncturing a capsule bin, and the inner space of each air inlet needle is communicated with the air outlet end of an air inlet hose. And the gas inlet end of the gas inlet hose is connected with a gas cylinder switch of the gas cylinder outlet. The dry powder inhaler disclosed by the invention expands the range of users.

This disclosure relates to flavoured nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime.

The present invention discloses drug combination microspheres, a preparation method, and a raw material composition. The raw material composition of the drug microspheres of the present invention comprises the following components: formoterol fumarate, mometasone furoate, and a solvent. The drug combination microspheres of the present invention have a reduced bulk density and significantly reduce the residue of the prepared powder inhaler in the inhalation device and capsule shell, which is beneficial for increasing lung deposition and has good drug development prospects.

The invention belongs to the technical field of antioxidant drugs, and particularly relates to application of a glutathione dry powder inhaler in preparation of drugs for treating radiation acute lung injury, the glutathione dry powder inhaler comprises the following active ingredients by mass percentage: 50%-60% of reduced glutathione, 10%-20% of a carrier and 20%-30% of a dispersant, totaling 100%, the carrier is mannitol, and the dispersing agent is L-leucine. According to the invention, the glutathione dry powder inhalant accurately delivers high-concentration GSH to an alveolar injury area through a lung targeting delivery system, synchronously activates endogenous antioxidant enzymes, inhibits lipid peroxidation and an inflammation source, and blocks release of proinflammatory factors, so that radiation-induced oxidation-inflammation cascade reaction is directly inhibited, alveolar structure damage is relieved, and the anti-inflammatory effect is achieved. And an efficient new treatment strategy is provided for RILI.

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.

An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.

A powder inhaler, a piercing mechanism (8), and a powder delivery mechanism (5). The powder inhaler comprises: a housing assembly (1); a depolymerization mechanism (2), provided with a depolymerization cavity (21) in communication with an inhalation nozzle (3); a cover body (4), capable of being configured to a first position so as to cover the inhalation nozzle (3) or a second position so as to expose the inhalation nozzle (3); and the powder delivery mechanism (5). The powder delivery mechanism (5) comprises: an annular body (51), wherein the annular body (51) is provided with a plurality of capsule cavities (510) for placing a powder capsule (9), a transmission assembly (6) is separately connected to the cover body (4) and the annular body (51), and in a process that the cover body (4) is configured from the first position to the second position, the cover body (4) is linked to the transmission assembly (6) to rotate, and the transmission assembly (6) is linked to the annular body (51) to rotate, such that the plurality of capsule cavities (510) are sequentially in communication with the depolymerization cavity (21); and a sealing belt (531), wherein a first end of the sealing belt (531) is connected to a belt winding wheel assembly (7), and a second end thereof is wound around the annular body (51) in the circumferential direction of the annular body (51) and covers cavity openings of the plurality of capsule cavities (510). During rotation, the annular body (51) is linked to the belt winding wheel assembly (7) to rotate, such that the sealing belt (531) is separated from the annular body (51) and is wound around the belt winding wheel assembly (7).

The invention discloses a cationic immune liposome dry powder inhaler as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The cationic immune liposome dry powder inhaler disclosed by the invention is prepared from siRNA (small interfering Ribonucleic Acid) used for KRAS mutation, (2, 3-dioleyloxypropyl)-trimethyl ammonium chloride, dipalmitic acid phosphatidylcholine, cholesterol, 1, 2-distearoyl-SN-glycerol-3-phosphorylethanolamine-N-maleimide-polyethylene glycol 2000, palbolizumab and a freeze-drying protective agent. The composition is prepared through a freeze-drying process. The preparation method of the dry powder inhaler comprises the following steps: preparing the cationic liposome carrying the siRNA, preparing the cationic immune liposome coupled with the antibody, and freeze-drying the dry powder inhaler. Compared with a traditional administration mode, the inhalant has the advantages of being simple in preparation process, good in drug stability, high in targeting performance, obvious in-vivo distribution advantage and the like, and a new strategy is provided for treatment of the non-small cell lung cancer.

Atomization devices and procedures are disclosed that provide enhancements to air-jet and other dry powder inhaler (DPI) technologies to improve and optimize atomization performance and expand dose loading capacity. Exemplary devices include, for example, an atomization chamber having a variable chamber size and an adjustment mechanism configured to adjust the chamber size between actuations. In use, the distance between the air-jet path of the atomization chamber and the top of the powder bed is generally maintained even as the powder is depleted during successive device actuations.

An inhaler set including an inhaler and a sensor unit exchangeably attached to the inhaler for detecting the use thereof. The inhaler is a powder inhaler and has a housing with a delivery opening configured a mouthpiece and with air inlet openings. The powder to be inhaled is stored inside the inhaler prior to discharge. The powder being atomized and is transported to the delivery opening by an air flow caused by inhalation from the air inlet openings to the delivery opening. The sensor unit can be attached to the inhaler such that at least one first air inlet opening is covered by the sensor unit in the attached state and at least one second air inlet opening is not covered by the sensor unit in the attached state. The sensor unit has at least one inhalation sensor for detecting the air flow through the first air inlet opening.

A powder inhaler, a piercing mechanism (8), and a powder delivery mechanism (5). The powder inhaler comprises: a housing assembly (1); a depolymerization mechanism (2), provided with a depolymerization cavity (21) in communication with an inhalation nozzle (3); a cover body (4), capable of being configured to a first position so as to cover the inhalation nozzle (3) or a second position so as to expose the inhalation nozzle (3); and the powder delivery mechanism (5). The powder delivery mechanism (5) comprises: an annular body (51), wherein the annular body (51) is provided with a plurality of capsule cavities (510) for placing a powder capsule (9), a transmission assembly (6) is separately connected to the cover body (4) and the annular body (51), and in a process that the cover body (4) is configured from the first position to the second position, the cover body (4) is linked to the transmission assembly (6) to rotate, and the transmission assembly (6) is linked to the annular body (51) to rotate, such that the plurality of capsule cavities (510) are sequentially in communication with the depolymerization cavity (21); and a sealing belt (531), wherein a first end of the sealing belt (531) is connected to a belt winding wheel assembly (7), and a second end thereof is wound around the annular body (51) in the circumferential direction of the annular body (51) and covers cavity openings of the plurality of capsule cavities (510). During rotation, the annular body (51) is linked to the belt winding wheel assembly (7) to rotate, such that the sealing belt (531) is separated from the annular body (51) and is wound around the belt winding wheel assembly (7).

The invention discloses an air inlet baffle, a dose protection plate, an inspiration trigger mechanism and a powder inhaler. The air inlet baffle is used for the powder inhaler and comprises a baffle body, a boss is arranged on the first surface of the baffle body, and the peripheral side face of the boss and the peripheral side face of the baffle body are arranged at intervals. Through the arrangement, the problems that in the prior art, a powder inhaler is poor in powder depolymerization effect and powder is prone to being wasted can be solved, the powder depolymerization effect can be improved, and the powder utilization rate is increased.