46 results about "Powder Inhaler" patented technology

The present invention relates to an ambroxol-ibuprofen cocrystal dry powder inhaler, a preparation method and application thereof, and belongs to the professional field of pharmaceutical preparations. The dry powder inhaler is mainly composed of ambroxol, ibuprofen and lactose, the molar ratio of ambroxol to ibuprofen is 1:1, and the mass ratio of lactose to ambroxol-ibuprofen cocrystal is 5-35%. The results of the rat lung tissue distribution experiment showed that the administration method of dry powder inhalation can significantly enhance the drug delivery efficiency in the lungs and greatly prolong the drug retention time in the lungs compared with the traditional intravenous administration. Pharmacodynamic experiments further revealed that the ambroxol-ibuprofen cocrystal dry powder inhaler can effectively inhibit the active expression of inflammatory factors in model animals, and reduce the accumulation of hydroxyproline (HYP) in lung tissue and serum, improve anti-fibrosis and anti-inflammatory capabilities, improve oxidative stress capabilities, thereby helping to delay the pathological process of pulmonary fibrosis, showing great development potential as an anti-pulmonary fibrosis drug.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The present invention relates to a device (20) for delivering a medicament (30) to a user via the nasal or pulmonary route. The device may be a pressurized metered dose inhaler (200), an active dry powder inhaler (300 / 400), a soft mist inhaler (500), or a nebulizer (600). The device (20) comprises a propellant energy source (40) for delivering the medicament (30), the propellant energy source (40) being or comprising an atmospheric gas (41) stored in a canister (45) separate from the medicament, adsorbed on an adsorbate (42) at a pressure of at least 2 bar, the atmospheric gas being released from the canister to dispense the medicament (30). The device includes a gas delivery mechanism (50) having a metering chamber (52) that has a greater capacity than a conventional pressurized metered dose inhaler filled with HFC propellant. The atmospheric-like gas (41), upon actuation, is released from the chamber and travels along the conduit (25) to displace a dose of medicament (30) from the dose chamber (80) undergoing aerosolization and exit the device as a plume (60) via a second conduit (27) and an outlet (28).

The utility model relates to the technical field of dry powder flow velocity monitoring, and discloses a flow velocity monitoring device of a dry powder inhaler, which comprises a dry powder storage tank, a suction nozzle is arranged on the outer wall of the dry powder storage tank, a suction channel is fixedly connected inside the dry powder storage tank, and a partition plate is fixedly connected to the outer wall of the suction channel. A gear ring is rotatably connected to the outer wall of the partition plate, a rotating handle is fixedly connected to the outer wall of the gear ring, a transmission gear is connected to the inner wall of the gear ring in a meshed mode, a rack is connected to the outer wall of the transmission gear in a meshed mode, and a closing plate is fixedly connected to the outer wall of the rack. According to the utility model, the rotating handle is pushed to drive the gear ring to rotate, then the transmission gear slides along with the rotation of the gear ring, and finally the flow rate port is opened and closed by the closing plate to adjust the size, so that the effects of adapting to the inspiration ability of different patients and improving the treatment accuracy can be achieved.

A powder inhaler assembly comprises a powder inhaler (2) comprising a metering device (10) having a dosing recess (11) and being movable, with respect to a container (8) and an inhalation channel (9), between an inactive state, in which the dosing recess (11) is in communication with an opening (12) of the container (8) to be filled with a dose of the powdered drug, and an active state, in which the dosing recess (11) is in communication with the inhalation channel (9) to allow inhalation of a dose of the powdered drug contained in the dosing recess (11) through a mouthpiece (6). An electronic module (3) may be attached to the powder inhaler (2) and comprises a contactless sensor (29) positioned and configured to detect the position or positions of at least part of the metering device (10) to detect at least when the metering device (10) is in the active state.

Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.

A breath-actuated dry powder inhaler (301, 401, 501), said inhaler comprising: a substantially planar housing consisting of a stack of substantially planar elements, said planar elements comprising a bottom plate (319, 419, 519), an intermediate plate (318, 418, 518) and a top plate (317, 417), said planar elements being parallel to each other, at least one planar element being provided with a projection, said projection being arranged between the bottom plate (319, 419, 519) and the intermediate plate (318, 418, 518) and the top plate (317, 417); the protrusions form a substantially disc-shaped air circulation chamber (302) in the stacked structure for depolymerizing entrained powdered medicament using the energy of the suction air flow; a plurality of air supply channels (307); an air supply area for the powder flow; and a discharge channel (312) of the inhaler; the chamber has a generally polygonal side wall (303) extending between a top wall and a bottom wall of the chamber about a central axis extending transverse to the floor, the height of the chamber being less than the diameter of the chamber. The inhaler has a planar dose compartment (323, 423, 523) received in a slidable manner between two of the three plates.

Aerosolization devices and procedures are described that improve air-jet dry powder inhaler (DPI) technologies and other types of inhalers, thereby optimizing aerosolization performance and expanding dosing capacity. One example device includes a variable-sized aerosolization chamber and an adjustment mechanism that allows the chamber size to be changed between activations. During use, the distance between the aerosolization chamber's air channel and the top of the powder bed remains virtually constant, even as the powder bed empties with each successive activation of the device.

The application discloses a powder medicine suction nozzle, and the waxy rice paper group is installed on the piston rod through the clamping assembly; blood or oral fluid of a wound is adhered to the waxy rice paper on the waxy rice paper group, so that the medicine is adhered to the wound and is blocked between the wound and the waxy rice paper, thereby avoiding medicine spilling when taking medicine and avoiding the problem of waste caused by the medicine falling off because the medicine cannot be adhered to the wound in time. In the second embodiment, the multiple layers of plastic films and the multiple layers of waxy rice papers are alternately stacked, so that the problem of multiple layers of penetration caused by excessive blood or oral fluid after the waxy rice paper contacts the wound is avoided, and the U-shaped groove facilitates the operation of taking off the plastic film. In the third embodiment, the steel connecting rod and the strong magnetic adsorption are utilized to pull the clamping plate to be clamped on the U-shaped clamping extension piece, so that the stable clamping effect is achieved, and the installation and replacement of the later layer of plastic film are facilitated.

The present disclosure provides a method for manufacturing an inhaler article having an upstream resilient element (101) for insertion into a holder to form an inhaler system for providing a dry powder to the lungs of a user, the manufacturing method comprising: moving a ribbon (402) of resilient material from a feeder reel (401) to a cutting stage (405); presenting the ribbon of resilient material to the cutting stage; cutting at least one disk of resilient material from the ribbon of resilient material to form at least one cut disk of resilient material; presenting the at least one cut disk of resilient material to a glue stage (501); dispensing at least one glue ring (502); applying the at least one glue ring to the at least one cut disk of resilient material; and, presenting the at least one cut disk of resilient material having an applied glue ring to an upstream end (120) of an inhaler article; affixing the at least one cut disk of resilient material having an applied glue ring to the upstream end of an inhaler article to form an inhaler article having an affixed upstream resilient element.

The passive dry powder inhaler comprises a box body, the box body comprises a gas cylinder box and a capsule box located at the top of the gas cylinder box, a gas cylinder is arranged in the gas cylinder box, compressed gas is arranged in the gas cylinder, a capsule bin is arranged in the capsule box, the top of the capsule box is open and provided with a top cover, and the top cover is provided with a suction nozzle. The bottom end of the suction nozzle is provided with an air suction needle used for puncturing a capsule, the capsule box is slidably connected with at least one set of buttons, the same set of buttons comprises two non-coaxial and parallel buttons, the buttons are provided with air inlet needles capable of puncturing a capsule bin, and the inner space of each air inlet needle is communicated with the air outlet end of an air inlet hose. And the gas inlet end of the gas inlet hose is connected with a gas cylinder switch of the gas cylinder outlet. The dry powder inhaler disclosed by the invention expands the range of users.

This disclosure relates to flavoured nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime.

The invention belongs to the technical field of antioxidant drugs, and particularly relates to application of a glutathione dry powder inhaler in preparation of drugs for treating radiation acute lung injury, the glutathione dry powder inhaler comprises the following active ingredients by mass percentage: 50%-60% of reduced glutathione, 10%-20% of a carrier and 20%-30% of a dispersant, totaling 100%, the carrier is mannitol, and the dispersing agent is L-leucine. According to the invention, the glutathione dry powder inhalant accurately delivers high-concentration GSH to an alveolar injury area through a lung targeting delivery system, synchronously activates endogenous antioxidant enzymes, inhibits lipid peroxidation and an inflammation source, and blocks release of proinflammatory factors, so that radiation-induced oxidation-inflammation cascade reaction is directly inhibited, alveolar structure damage is relieved, and the anti-inflammatory effect is achieved. And an efficient new treatment strategy is provided for RILI.

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.

A powder inhaler, a piercing mechanism (8), and a powder delivery mechanism (5). The powder inhaler comprises: a housing assembly (1); a depolymerization mechanism (2), provided with a depolymerization cavity (21) in communication with an inhalation nozzle (3); a cover body (4), capable of being configured to a first position so as to cover the inhalation nozzle (3) or a second position so as to expose the inhalation nozzle (3); and the powder delivery mechanism (5). The powder delivery mechanism (5) comprises: an annular body (51), wherein the annular body (51) is provided with a plurality of capsule cavities (510) for placing a powder capsule (9), a transmission assembly (6) is separately connected to the cover body (4) and the annular body (51), and in a process that the cover body (4) is configured from the first position to the second position, the cover body (4) is linked to the transmission assembly (6) to rotate, and the transmission assembly (6) is linked to the annular body (51) to rotate, such that the plurality of capsule cavities (510) are sequentially in communication with the depolymerization cavity (21); and a sealing belt (531), wherein a first end of the sealing belt (531) is connected to a belt winding wheel assembly (7), and a second end thereof is wound around the annular body (51) in the circumferential direction of the annular body (51) and covers cavity openings of the plurality of capsule cavities (510). During rotation, the annular body (51) is linked to the belt winding wheel assembly (7) to rotate, such that the sealing belt (531) is separated from the annular body (51) and is wound around the belt winding wheel assembly (7).

Atomization devices and procedures are disclosed that provide enhancements to air-jet and other dry powder inhaler (DPI) technologies to improve and optimize atomization performance and expand dose loading capacity. Exemplary devices include, for example, an atomization chamber having a variable chamber size and an adjustment mechanism configured to adjust the chamber size between actuations. In use, the distance between the air-jet path of the atomization chamber and the top of the powder bed is generally maintained even as the powder is depleted during successive device actuations.

An inhaler set including an inhaler and a sensor unit exchangeably attached to the inhaler for detecting the use thereof. The inhaler is a powder inhaler and has a housing with a delivery opening configured a mouthpiece and with air inlet openings. The powder to be inhaled is stored inside the inhaler prior to discharge. The powder being atomized and is transported to the delivery opening by an air flow caused by inhalation from the air inlet openings to the delivery opening. The sensor unit can be attached to the inhaler such that at least one first air inlet opening is covered by the sensor unit in the attached state and at least one second air inlet opening is not covered by the sensor unit in the attached state. The sensor unit has at least one inhalation sensor for detecting the air flow through the first air inlet opening.

A dry powder inhaler is provided, including an upper structure, a lower structure, and a piercing base. The upper structure undergoes a longitudinal linear movement relative to the lower structure, the upper structure is formed with a capsule chamber and a piercing channel arranged laterally outside of the capsule chamber, one or more piercing needles undergo a lateral piercing movement along the piercing channel, a drive structure is provided among the upper structure, the lower structure, and the piercing structure. When the upper structure undergoes a longitudinal linear movement relative to the lower structure, the drive structure drives the piercing needles to move laterally along the piercing channel, thereby piercing a capsule positioned in the capsule chamber. The dry powder inhaler enables the capsule to be pierced from the side along the piercing channel by pressing the lower structure and the upper structure.

1. The name of the design product: dry powder inhaler. 2. The use of the design product: the design product is used to assist dry powder inhalation of medicine. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

This disclosure relates to nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime.

A dry-powder inhaler having a body and a mouthpiece provided with a dispensing orifice through which the user inhales, a chamber, a reservoir containing a dose of dry powder to be inhaled and having a lateral outlet opening. The reservoir is disposed in the chamber, the diameter of the reservoir being less than the diameter of the chamber, so that, in the loaded position, the reservoir can move in the chamber. The body has tangential channels adapted to bring a flow of inhalation air tangentially into the chamber, which, during inhalation, generates an orbital movement of the reservoir in the chamber, in the loaded position. The reservoir has an external profile defining an inscribed volume forming an external volume of the reservoir that is greater than the internal volume of the reservoir that contains the powder.

The invention relates to a double-capsule type medicine powder suction device, and belongs to the field of medical instruments. Comprising a suction nozzle assembly, a capsule bin plate and a push button assembly. Wherein two capsule bins are arranged in the capsule bin plate side by side, the distances between the capsule bins and the push button assembly are the same, the push button assembly is arranged on a single side and comprises four needles which are fixedly arranged in two rows and two columns, needle holes corresponding to the positions of the needles are formed in the capsule bin plate, and the needle holes are communicated with the capsule bin plate. And the needle can enter the capsule bin through the needle hole. Through the cooperation of the capsule bin plate and the push button assembly, in the using process of a patient, medicine in the two capsules can be released through one-time using action, the medication efficiency of the patient when the patient uses compound medicine or multi-dose medicine is greatly improved, and the compliance is improved.

The present invention provides a stick for a dry powder inhaler comprising a filter portion, a capsule portion, and a tube portion, wherein the capsule portion contains nicotine dry powder, and one or more of the filter portion and the tube portion contain a cough suppressant, and a dry powder inhaler comprising the same.

Methods for treating or preventing a pulmonary fungal infection in a recipient of, for example, a lung transplant are disclosed.

A dry powder inhaler comprising: - a body (110) and a mouthpiece (120) having a delivery orifice (121) through which the user inhales, - a chamber (111), - a reservoir (10) containing a dose of dry powder to be inhaled and having a lateral outlet orifice (11), said reservoir (10) being disposed within said chamber (111), the diameter of said reservoir (10) being smaller than the diameter of said chamber (111), said reservoir (10) having an external profile (15) defining an inscribed volume forming an external volume of the reservoir greater than the internal volume of the reservoir containing the powder. (See Figure 1 for abbreviations.)

The utility model relates to a rotating shaft type single-dose capsule type powder inhaler, and belongs to the field of medical instruments. Comprising an outer cover, a suction nozzle, a base and a push button assembly. Wherein an integrated rotating shaft structure is arranged at the lower end of the suction nozzle, an embedded C-shaped embracing ring is arranged on one side of the upper end of the base, the embracing ring and the base are of an integrated structure, and the rotating shaft is matched with the embracing ring so that the suction nozzle can be rotationally fixed to the base along the horizontal axis. By the adoption of the structure, the installation steps of the whole inhaler are simplified, the installation process is faster and more convenient, meanwhile, the number of needed parts is reduced, and the production cost is saved.

The present invention relates to pharmaceuticals for inhalation, containing aurothioglucose, and to an inhaler, preferably a powder inhaler, dosing inhaler or atomizer containing such pharmaceuticals. The invention provides these pharmaceuticals for use in the prevention and therapy of pulmonary diseases, in particular infectious and inflammatory-infectious pulmonary diseases. 20 26 20 53 78 07 J ul 2 02 6 2 0 2 6 2 0 2 6 2 0 5 3 7 8 0 7 J u l

The present invention relates to a method of treating asthma comprising administering as rescue medication a fixed-dose dry powder inhalation composition comprising fluticasone propionate and salbutamol sulfate in patients aged > 4 years on an as-needed (PRN) basis, wherein the fluticasone propionate is administered at a delivered dose of 22-59 micrograms per inhalation, the salbutamol sulfate is administered at a delivered dose of 92-124 micrograms per inhalation, and the treatment provides one or more of: an extended time to first severe clinical asthma exacerbation compared to salbutamol sulfate rescue treatment, a reduced total annualized systemic corticosteroid (SCS) exposure compared to salbutamol sulfate rescue treatment, a reduced annualized rate of severe clinical asthma exacerbations compared to salbutamol sulfate rescue treatment. Also provided is a fixed-dose dry powder inhalation composition and a dry powder inhaler for use in performing the method of the invention.

The application discloses an electromagnetic valve and a dry powder inhaler auxiliary inhalation device containing the electromagnetic valve, and the electromagnetic valve comprises a valve shell, a valve core, a spring and an electromagnet which are arranged in the valve shell; the spring is arranged between the valve core and the electromagnet; the valve shell is a cavity with an open upper end and a closed lower end or a blocking structure for blocking the iron core. The electromagnetic valve provided by the application has the advantages of simple structure, small size, sealing when no power supply, opening when power supply, and opening when the air inlet needle is inflated. The application further provides the dry powder inhaler auxiliary inhalation device with the electromagnetic valve, which can supplement air flow for the dry powder inhaler, assist in drug inhalation, expand the use range of the dry powder inhaler, and can be used by people with bronchial diseases, children and the old.