125 results about "Powder Inhaler" patented technology

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation; a mouthpiece through which the medicament is inhaled by a user; an indexing wheel for indexing the blister strip; an opening mechanism for opening the blisters; an actuator which is movable between a first position and a second position in order to operate the indexing wheel and the opening mechanism; and a coupling mechanism for coupling the actuator to the indexing wheel so that the indexing wheel rotates together with the actuator during part of the motion of the actuator; characterized in that the coupling mechanism comprises a shuttle that rotates on the same axis as, and translates axially relative to, the indexing wheel.

The invention discloses a dry powder inhaler shell forming mold with a strength detection function, and relates to the technical field of plastic molding.The dry powder inhaler shell forming mold comprises a control system, a feeding system, a screw type conveying system and a rack, a melting barrel is installed on the rack, a forming assembly is installed below the melting barrel, and a detection assembly is installed on one side of the forming assembly; a driving motor is mounted in the melting cylinder, a feeding pipe is connected to the upper end of the melting cylinder, a discharging pipe is connected to the lower end of the melting cylinder, a coil A is arranged on the outer side of the sleeve, the feeding pipe is connected with the feeding system, and the discharging pipe, the screw type conveying system and the forming assembly are connected in series through a pipeline; a spiral cylinder and a conical tray are mounted in the melting cylinder, a sieve plate B is mounted on the outer side of the conical tray, a spiral sheet is arranged on the outer side of the cylinder, and a coil B and a permanent magnet are mounted in the cylinder; the conical tray is matched with the permanent magnet through the coil B to realize vibration and scattering of plastic particles, and the spiral sheet is matched with the coil A to heat the plastic particles and convey the heated plastic particles.

An inhaler kit is described comprising an inhaler (10) and a sensor unit (40) replaceably attachable to the inhaler (10) for detecting use of the inhaler (10). The inhaler (10) is designed as a powder inhaler and has a housing (12) with a delivery opening (14) designed as a mouth and with a plurality of intake openings (20, 22), in which the powder to be inhaled is stored on the inside of the inhaler (10) prior to discharge, said powder being atomized by means of an air flow resulting from inhalation from the intake openings (20, 22) to the delivery opening (14) and conveyed to the delivery opening (14). The sensor unit (40) is provided for attachment to the inhaler (10), the sensor unit being attachable to the inhaler (10) such that the at least one first air inlet opening (20) is covered by the sensor unit (40) in the attached state and the at least one second air inlet opening (22) is not covered by the sensor unit (40) in the attached state. The sensor unit (40) comprises at least one suction sensor (82) for detecting an air flow through the first air inlet opening (20).

The present invention relates to a pharmaceutical composition in inhalable pre-metered dry powder form that comprises at least one excipient (for example carrier) and at least one active substance used against viral diseases to locally administer it to the lungs for use in the treatment of symptoms of viral lung diseases including COVID-19 caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-COV-2) by means of dry powder inhaler through inhalation. The present invention also relates to methods for preparation of said pharmaceutical composition and the use of these active substances in symptoms caused by COVID-19. similar viral lung diseases, influenza.

The invention relates to an andrographolide nanocrystal suspension, preparation thereof and application of the andrographolide nanocrystal suspension in preparation of an andrographolide nanocrystal dry powder inhaler with an anti-inflammatory effect. The andrographolide nanocrystal suspension contains a) an active component andrographolide nanocrystal; b) a stabilizer; wherein the content of andrographolide in the suspension is 0.1%-30%, and the content of the stabilizer is 0.1%-5%. According to the andrographolide nanocrystal dry powder inhalant and the preparation method thereof, andrographolide nanocrystals are prepared into micro powder by adopting a spray drying technology, and auxiliary material addition and a preparation process are optimized, so that the andrographolide nanocrystal dry powder inhalant with good inhalation performance is successfully prepared and directly acts on the respiratory tract through a pulmonary drug delivery system, the administration dosage is reduced, and the inhalation effect is improved. Higher lung local concentration is obtained, the first-pass effect of the liver is avoided, meanwhile, the efflux effect of p-glycoprotein is avoided as much as possible, and then the bioavailability is improved; the technical problem that the bioavailability is poor due to the fact that andrographolide is excreted through p-glycoprotein and rapidly absorbed and metabolized in the intestinal tract is solved.

Provided are a rotating mechanism (2), a dosage protection mechanism (3), a breath triggering apparatus (100), and a dry powder inhaler (800). The rotating mechanism (2) is applied to the breath triggering apparatus (100), and the rotating mechanism (2) comprises: a rotating shaft (22), an outer side surface of which is provided with a notch (221); and a baffle (21) connected to the outer side surface of the rotating shaft (22), wherein the rotating mechanism (2) is rotatable between a first position and a second position, and when in the first position, blocks a first airflow channel of the breath triggering apparatus (100); when moving from the first position to the second position, the baffle (21) rotates around the rotating shaft (22) to open the first airflow channel. By means of the above configuration, the problem of inadequate drug powder deaggregation in the prior art can be effectively resolved.

The invention provides a powder inhaler. The powder inhaler comprises a shell assembly; the depolymerization mechanism is provided with a depolymerization cavity; the powder delivery mechanism is arranged in the shell assembly and provided with a plurality of capsule cavities, and the capsule cavities are used for storing powder capsules; the powder delivery mechanism can move relative to the depolymerization cavity, so that the plurality of capsule cavities are sequentially communicated with the depolymerization cavity; one of the shell assembly and the powder delivery mechanism is provided with a first limiting piece, and the other one of the shell assembly and the powder delivery mechanism is provided with a plurality of second limiting pieces; and when the capsule cavity is aligned with the depolymerization cavity, the first limiting piece is clamped with one second limiting piece. The powder inhaler can provide multiple doses of powder capsules; and moreover, the capsule cavity and the depolymerization cavity can be prevented from being misplaced, so that the proportional distribution of air inflow and the suction resistance and depolymerization effect are not influenced.

The utility model provides a suction nozzle with multistage depolymerization grid trays and a medicine powder inhaler, the suction nozzle comprises a suction pipe, the inner wall of the suction pipe is provided with a spiral channel and three layers of depolymerization grid trays, and the spiral channel is located between the adjacent layers of depolymerization grid trays; each layer of depolymerization grid plate is provided with a medicine through hole, the shape of the medicine through hole is selected from a square shape, a round shape or an oval shape, the hole diameter is gradually reduced from bottom to top, and the medicine through hole is in an inverted funnel shape. According to the utility model, agglomerated particles are dissociated by adding the depolymerization grid plates, and then the multiple layers of grid plates are connected through the spiral channel, so that the dissociation effect is further improved by step-by-step acceleration; tests show that the drug delivery dosage can be increased, particle depolymerization is improved, and the number of layers of depolymerization grid plates of FPF is increased; the optimal aperture range of the medicine through holes in each layer of depolymerization grid plate capable of improving the atomization effect is obtained through research, and a new solution is provided for improvement of the structure of the dry powder inhaler.

The present invention relates to an ambroxol-ibuprofen cocrystal dry powder inhaler, a preparation method and application thereof, and belongs to the professional field of pharmaceutical preparations. The dry powder inhaler is mainly composed of ambroxol, ibuprofen and lactose, the molar ratio of ambroxol to ibuprofen is 1:1, and the mass ratio of lactose to ambroxol-ibuprofen cocrystal is 5-35%. The results of the rat lung tissue distribution experiment showed that the administration method of dry powder inhalation can significantly enhance the drug delivery efficiency in the lungs and greatly prolong the drug retention time in the lungs compared with the traditional intravenous administration. Pharmacodynamic experiments further revealed that the ambroxol-ibuprofen cocrystal dry powder inhaler can effectively inhibit the active expression of inflammatory factors in model animals, and reduce the accumulation of hydroxyproline (HYP) in lung tissue and serum, improve anti-fibrosis and anti-inflammatory capabilities, improve oxidative stress capabilities, thereby helping to delay the pathological process of pulmonary fibrosis, showing great development potential as an anti-pulmonary fibrosis drug.

The invention relates to an ambroxol and ibuprofen eutectic dry powder inhaler as well as a preparation method and application thereof, and belongs to the professional field of pharmaceutical preparations. The dry powder inhalant is mainly composed of ambroxol, ibuprofen and lactose, the molar ratio of ambroxol to ibuprofen is 1: 1, and the mass ratio of lactose to ambroxol and ibuprofen eutectic is 5-35%. A rat lung tissue distribution experiment result shows that compared with traditional intravenous administration, the delivery efficiency of the medicine in the lung can be remarkably enhanced by adopting a dry powder inhalation administration mode, and the retention time of the medicine in the lung is greatly prolonged. The pharmacodynamic experiment further reveals that the ambroxol and ibuprofen eutectic dry powder inhalant can effectively inhibit the active expression of inflammatory factors in a model animal body, reduce the accumulation of hydroxyproline (HYP) in lung tissues and serum, improve the anti-fibrosis and anti-inflammatory ability and improve the oxidative stress ability, so that the pathological process of pulmonary fibrosis is delayed, and the inhalant can be used for treating pulmonary fibrosis. The compound shows huge development potential as an anti-pulmonary fibrosis drug.

1. Name of the Design Product: Integrated Medication Recorder (Dry Powder Inhaler). 2. Use of the Design Product: To record medication usage. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Combined State Diagram.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The present invention relates to a device (20) for delivering a medicament (30) to a user via the nasal or pulmonary route. The device may be a pressurized metered dose inhaler (200), an active dry powder inhaler (300 / 400), a soft mist inhaler (500), or a nebulizer (600). The device (20) comprises a propellant energy source (40) for delivering the medicament (30), the propellant energy source (40) being or comprising an atmospheric gas (41) stored in a canister (45) separate from the medicament, adsorbed on an adsorbate (42) at a pressure of at least 2 bar, the atmospheric gas being released from the canister to dispense the medicament (30). The device includes a gas delivery mechanism (50) having a metering chamber (52) that has a greater capacity than a conventional pressurized metered dose inhaler filled with HFC propellant. The atmospheric-like gas (41), upon actuation, is released from the chamber and travels along the conduit (25) to displace a dose of medicament (30) from the dose chamber (80) undergoing aerosolization and exit the device as a plume (60) via a second conduit (27) and an outlet (28).

The utility model relates to the technical field of dry powder flow velocity monitoring, and discloses a flow velocity monitoring device of a dry powder inhaler, which comprises a dry powder storage tank, a suction nozzle is arranged on the outer wall of the dry powder storage tank, a suction channel is fixedly connected inside the dry powder storage tank, and a partition plate is fixedly connected to the outer wall of the suction channel. A gear ring is rotatably connected to the outer wall of the partition plate, a rotating handle is fixedly connected to the outer wall of the gear ring, a transmission gear is connected to the inner wall of the gear ring in a meshed mode, a rack is connected to the outer wall of the transmission gear in a meshed mode, and a closing plate is fixedly connected to the outer wall of the rack. According to the utility model, the rotating handle is pushed to drive the gear ring to rotate, then the transmission gear slides along with the rotation of the gear ring, and finally the flow rate port is opened and closed by the closing plate to adjust the size, so that the effects of adapting to the inspiration ability of different patients and improving the treatment accuracy can be achieved.

A powder inhaler assembly comprises a powder inhaler (2) comprising a metering device (10) having a dosing recess (11) and being movable, with respect to a container (8) and an inhalation channel (9), between an inactive state, in which the dosing recess (11) is in communication with an opening (12) of the container (8) to be filled with a dose of the powdered drug, and an active state, in which the dosing recess (11) is in communication with the inhalation channel (9) to allow inhalation of a dose of the powdered drug contained in the dosing recess (11) through a mouthpiece (6). An electronic module (3) may be attached to the powder inhaler (2) and comprises a contactless sensor (29) positioned and configured to detect the position or positions of at least part of the metering device (10) to detect at least when the metering device (10) is in the active state.

The invention discloses a powder inhaler. The powder inhaler comprises a functional mechanism, a suction nozzle and an outer cover. The functional mechanism comprises a suction channel; the suction nozzle is communicated with the suction channel; the outer cover is in linkage fit with the functional mechanism and is limited to rotate back and forth between a first position and a second position; the outer cover is configured to shield the suction nozzle at the first position and not shield the suction nozzle at the second position. The stroke of the outer cover rotating from the first position to the second position comprises a cover opening idle stroke and a cover opening load stroke, the inner cover and the outer cover do not trigger the action of the functional mechanism in the cover opening idle stroke, and the inner cover and the outer cover trigger the functional mechanism to deliver powder to the suction channel in the cover opening load stroke; and / or, the stroke of resetting the outer cover from the second position to the first position comprises a cover closing idle stroke and a cover closing load stroke, the inner cover and the outer cover do not trigger the function mechanism to act in the cover closing idle stroke, and the inner cover and the outer cover trigger the function mechanism to reset in the cover closing load stroke. By means of the arrangement, good linkage among the mechanisms is achieved in the cover opening and closing process.

Containment units, dry powder inhalers, delivery systems, and methods for the same are disclosed. Exemplary devices are configured to have inlets and outlets which are formed with the containment walls of a containment unit. Air jets formed by the configuration of inlet(s) and outlet(s) inside the containment unit create significant turbulence and deaggregate the powder. Delivery system components downstream of the containment unit may integrate the exiting aerosol plume with a low flow nasal cannula air stream for delivery to a subject.

The invention relates to a powder inhaler comprising a body (10) accommodating a strip (20) of at least two individual reservoirs (20a, 20b, 20c, 20d), each individual reservoir having a cavity (21) containing a dose of powder and a closure layer (22) for sealing the cavity (21), the body (10) comprising a head portion (11) and a support portion (12), the head portion (11) and the support portion (12) being connected by at least one articulation (13) such that the body (10) is deformable and / or movable between an open position and a closed position, wherein the head portion (11) comprises a dispensing port (110) and a perforating element (112) connected to the dispensing port (110) and capable, during actuation, of piercing the closure layer (22) in order to open an individual reservoir (20a, 20b, 20c, 20d), and wherein the head portion (11) comprises at least one axial projection (115) associated with the perforating element (112), and wherein the strip (20) of reservoirs comprises at least one lateral edge provided with cut-outs (24a, 24b, 24c) arranged between the individual reservoirs (20a, 20b, 20c, 20d), which define flaps (25a, 25b, 25c, 25d) for each individual reservoir (20a, 20b, 20c, 20d), and wherein each axial projection (115) folds a respective flap (25a, 25b, 25c, 25d) during actuation.

A breath-actuated dry powder inhaler (301, 401, 501), said inhaler comprising: a substantially planar housing consisting of a stack of substantially planar elements, said planar elements comprising a bottom plate (319, 419, 519), an intermediate plate (318, 418, 518) and a top plate (317, 417), said planar elements being parallel to each other, at least one planar element being provided with a projection, said projection being arranged between the bottom plate (319, 419, 519) and the intermediate plate (318, 418, 518) and the top plate (317, 417); the protrusions form a substantially disc-shaped air circulation chamber (302) in the stacked structure for depolymerizing entrained powdered medicament using the energy of the suction air flow; a plurality of air supply channels (307); an air supply area for the powder flow; and a discharge channel (312) of the inhaler; the chamber has a generally polygonal side wall (303) extending between a top wall and a bottom wall of the chamber about a central axis extending transverse to the floor, the height of the chamber being less than the diameter of the chamber. The inhaler has a planar dose compartment (323, 423, 523) received in a slidable manner between two of the three plates.

Aerosolization devices and procedures are described that improve air-jet dry powder inhaler (DPI) technologies and other types of inhalers, thereby optimizing aerosolization performance and expanding dosing capacity. One example device includes a variable-sized aerosolization chamber and an adjustment mechanism that allows the chamber size to be changed between activations. During use, the distance between the aerosolization chamber's air channel and the top of the powder bed remains virtually constant, even as the powder bed empties with each successive activation of the device.

A dry-powder inhaler may include a casing. The casing may include a first casing portion, a second casing portion, and a hinge arrangement connecting the first casing portion and the second casing portion. The dry-powder inhaler may be assembled via folding the first casing portion and the second casing portion together. The first casing portion may include a cavity for receiving a dose blister foil. The cavity may be adapted to contain a dry-powder medicament. The first casing portion and the second casing portion, when folded together, may define an inlet for allowing a lidding foil to extend out therefrom. The casing may further include an outlet nozzle for providing the medicament. The outlet nozzle may extend at an angle from one of the first casing portion and the second casing portion.

A dual-reservoir dry powder inhaler apparatus, belonging to the field of administration apparatuses. A first drug storage barrel (901) and a second drug storage barrel (902) are arranged. A first drug pit (1604) and a second drug pit (1603) are correspondingly arranged below the first drug storage barrel (901) and the second drug storage barrel (902), respectively. A first delivery channel and a second delivery channel are arranged. One end of the first delivery channel and one end of the second delivery channel correspond to the first drug pit (1604) and the second drug pit (1603), respectively, and the other end of the first delivery channel and the other end of the second delivery channel are connected to a dispersion cavity. Two drugs are separately stored in the first drug storage barrel (901) and the second drug storage barrel (902). A "rotary disc" type dose allocation structure is adopted, and the drugs are delivered to the same dispersion cavity by means of the separate drug pits and the separate delivery channels and then delivered to a drug outlet (101) by means of a suction nozzle channel. The processes of dispensing, allocating a single inhalation dose, and delivering to the dispersion cavity to be delivered to the drug outlet (101) for the drugs in the first drug storage barrel (901) and the second drug storage barrel (902) are simultaneously conducted, thereby ensuring that the drugs at two doses can be dispersed and delivered into the body of a patient simultaneously. It can be ensured that the two drugs do not interfere with each other in the storage and dose allocation processes. The dual-reservoir dry powder inhaler apparatus can be widely applied to the field of design and manufacture of dry powder inhaler apparatuses.

The application discloses a powder medicine suction nozzle, and the waxy rice paper group is installed on the piston rod through the clamping assembly; blood or oral fluid of a wound is adhered to the waxy rice paper on the waxy rice paper group, so that the medicine is adhered to the wound and is blocked between the wound and the waxy rice paper, thereby avoiding medicine spilling when taking medicine and avoiding the problem of waste caused by the medicine falling off because the medicine cannot be adhered to the wound in time. In the second embodiment, the multiple layers of plastic films and the multiple layers of waxy rice papers are alternately stacked, so that the problem of multiple layers of penetration caused by excessive blood or oral fluid after the waxy rice paper contacts the wound is avoided, and the U-shaped groove facilitates the operation of taking off the plastic film. In the third embodiment, the steel connecting rod and the strong magnetic adsorption are utilized to pull the clamping plate to be clamped on the U-shaped clamping extension piece, so that the stable clamping effect is achieved, and the installation and replacement of the later layer of plastic film are facilitated.

The present disclosure provides a method for manufacturing an inhaler article having an upstream resilient element (101) for insertion into a holder to form an inhaler system for providing a dry powder to the lungs of a user, the manufacturing method comprising: moving a ribbon (402) of resilient material from a feeder reel (401) to a cutting stage (405); presenting the ribbon of resilient material to the cutting stage; cutting at least one disk of resilient material from the ribbon of resilient material to form at least one cut disk of resilient material; presenting the at least one cut disk of resilient material to a glue stage (501); dispensing at least one glue ring (502); applying the at least one glue ring to the at least one cut disk of resilient material; and, presenting the at least one cut disk of resilient material having an applied glue ring to an upstream end (120) of an inhaler article; affixing the at least one cut disk of resilient material having an applied glue ring to the upstream end of an inhaler article to form an inhaler article having an affixed upstream resilient element.

The passive dry powder inhaler comprises a box body, the box body comprises a gas cylinder box and a capsule box located at the top of the gas cylinder box, a gas cylinder is arranged in the gas cylinder box, compressed gas is arranged in the gas cylinder, a capsule bin is arranged in the capsule box, the top of the capsule box is open and provided with a top cover, and the top cover is provided with a suction nozzle. The bottom end of the suction nozzle is provided with an air suction needle used for puncturing a capsule, the capsule box is slidably connected with at least one set of buttons, the same set of buttons comprises two non-coaxial and parallel buttons, the buttons are provided with air inlet needles capable of puncturing a capsule bin, and the inner space of each air inlet needle is communicated with the air outlet end of an air inlet hose. And the gas inlet end of the gas inlet hose is connected with a gas cylinder switch of the gas cylinder outlet. The dry powder inhaler disclosed by the invention expands the range of users.

This disclosure relates to flavoured nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime.

The present invention discloses drug combination microspheres, a preparation method, and a raw material composition. The raw material composition of the drug microspheres of the present invention comprises the following components: formoterol fumarate, mometasone furoate, and a solvent. The drug combination microspheres of the present invention have a reduced bulk density and significantly reduce the residue of the prepared powder inhaler in the inhalation device and capsule shell, which is beneficial for increasing lung deposition and has good drug development prospects.

The invention belongs to the technical field of antioxidant drugs, and particularly relates to application of a glutathione dry powder inhaler in preparation of drugs for treating radiation acute lung injury, the glutathione dry powder inhaler comprises the following active ingredients by mass percentage: 50%-60% of reduced glutathione, 10%-20% of a carrier and 20%-30% of a dispersant, totaling 100%, the carrier is mannitol, and the dispersing agent is L-leucine. According to the invention, the glutathione dry powder inhalant accurately delivers high-concentration GSH to an alveolar injury area through a lung targeting delivery system, synchronously activates endogenous antioxidant enzymes, inhibits lipid peroxidation and an inflammation source, and blocks release of proinflammatory factors, so that radiation-induced oxidation-inflammation cascade reaction is directly inhibited, alveolar structure damage is relieved, and the anti-inflammatory effect is achieved. And an efficient new treatment strategy is provided for RILI.

1. Name of the product of this design: Disposable dry powder inhaler. 2. Purpose of the product with this design: The product with this design is used for inhalation administration of drugs. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.